Randolph Y. Hampton - Publications

University of California, San Diego, La Jolla, CA 
Cell Biology, Biochemistry

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY. Direct and essential function for Hrd3 in ER-associated degradation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27170191 DOI: 10.1073/pnas.1603079113  1
2013 Theesfeld CL, Hampton RY. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. The Journal of Biological Chemistry. 288: 8519-30. PMID 23306196 DOI: 10.1074/jbc.M112.404517  1
2012 Hampton RY, Sommer T. Finding the will and the way of ERAD substrate retrotranslocation. Current Opinion in Cell Biology. 24: 460-6. PMID 22854296 DOI: 10.1016/j.ceb.2012.05.010  1
2012 Li S, Spooner RA, Hampton RY, Lord JM, Roberts LM. Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. Plos One. 7: e41119. PMID 22829918 DOI: 10.1371/journal.pone.0041119  1
2011 Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. The Journal of Biological Chemistry. 286: 26298-307. PMID 21628456 DOI: 10.1074/jbc.M111.244798  1
2011 Hampton RY. San1-mediated quality control: substrate recognition "sans" chaperones. Molecular Cell. 41: 2-3. PMID 21211716 DOI: 10.1016/j.molcel.2010.12.022  1
2010 Heck JW, Cheung SK, Hampton RY. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proceedings of the National Academy of Sciences of the United States of America. 107: 1106-11. PMID 20080635 DOI: 10.1073/pnas.0910591107  1
2010 Carroll SM, Hampton RY. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. The Journal of Biological Chemistry. 285: 5146-56. PMID 19940128 DOI: 10.1074/jbc.M109.067876  1
2009 Garza RM, Tran PN, Hampton RY. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. The Journal of Biological Chemistry. 284: 35368-80. PMID 19776008 DOI: 10.1074/jbc.M109.023994  1
2009 Sato BK, Schulz D, Do PH, Hampton RY. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Molecular Cell. 34: 212-22. PMID 19394298 DOI: 10.1016/j.molcel.2009.03.010  1
2009 Garza RM, Sato BK, Hampton RY. In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. The Journal of Biological Chemistry. 284: 14710-22. PMID 19324879 DOI: 10.1074/jbc.M809607200  1
2009 Hampton RY, Garza RM. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chemical Reviews. 109: 1561-74. PMID 19243134 DOI: 10.1021/cr800544v  1
2008 Hampton RY. A cholesterol toggle switch. Cell Metabolism. 8: 451-3. PMID 19041760 DOI: 10.1016/j.cmet.2008.11.006  1
2008 Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 4506-20. PMID 18667535 DOI: 10.1091/mbc.E07-11-1188  1
2008 Bazirgan OA, Hampton RY. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. The Journal of Biological Chemistry. 283: 12797-810. PMID 18321851 DOI: 10.1074/jbc.M801122200  1
2007 Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/jbc.M703320200  1
2006 Sato BK, Hampton RY. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast (Chichester, England). 23: 1053-64. PMID 17083136 DOI: 10.1002/yea.1407  1
2006 Bazirgan OA, Garza RM, Hampton RY. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. The Journal of Biological Chemistry. 281: 38989-9001. PMID 17035235 DOI: 10.1074/jbc.M608174200  1
2005 Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. The Embo Journal. 24: 3917-26. PMID 16270032 DOI: 10.1038/sj.emboj.7600855  1
2005 Federovitch CM, Ron D, Hampton RY. The dynamic ER: experimental approaches and current questions. Current Opinion in Cell Biology. 17: 409-14. PMID 15975777 DOI: 10.1016/j.ceb.2005.06.010  1
2005 Garza RM, Hampton RY. Cell biology: sterol sensor comes up for air. Nature. 435: 37-8. PMID 15875007 DOI: 10.1038/435037a  1
2005 Bazirgan OA, Hampton RY. Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nature Cell Biology. 7: 207-9. PMID 15738968 DOI: 10.1038/ncb0305-207  1
2005 Shearer AG, Hampton RY. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. The Embo Journal. 24: 149-59. PMID 15635451 DOI: 10.1038/sj.emboj.7600498  1
2004 Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. The Journal of Cell Biology. 167: 23-5. PMID 15479733 DOI: 10.1083/jcb.200408117  1
2004 Shearer AG, Hampton RY. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry. 279: 188-96. PMID 14570925 DOI: 10.1074/jbc.M307734200  1
2003 Hampton RY. IRE1: a role in UPREgulation of ER degradation. Developmental Cell. 4: 144-6. PMID 12586055 DOI: 10.1016/S1534-5807(03)00032-7  1
2002 Hampton RY. ER-associated degradation in protein quality control and cellular regulation. Current Opinion in Cell Biology. 14: 476-82. PMID 12383799 DOI: 10.1016/S0955-0674(02)00358-7  1
2002 Cronin SR, Rao R, Hampton RY. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. The Journal of Cell Biology. 157: 1017-28. PMID 12058017 DOI: 10.1083/jcb.200203052  1
2002 Bays NW, Hampton RY. Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Current Biology : Cb. 12: R366-71. PMID 12015140 DOI: 10.1016/S0960-9822(02)00862-X  1
2001 Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY. HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Molecular Biology of the Cell. 12: 4114-28. PMID 11739805  1
2001 Gardner RG, Shearer AG, Hampton RY. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Molecular and Cellular Biology. 21: 4276-91. PMID 11390656 DOI: 10.1128/MCB.21.13.4276-4291.2001  1
2001 Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biology. 3: 24-9. PMID 11146622 DOI: 10.1038/35050524  1
2001 Gardner RG, Shan H, Matsuda SPT, Hampton RY. An Oxysterol-derived Positive Signal for 3-Hydroxy-3-methylglutaryl-CoA Reductase Degradation in Yeast Journal of Biological Chemistry. 276: 8681-8694. PMID 11134013 DOI: 10.1074/jbc.M007888200  1
2000 Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C, Hampton RY. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. The Journal of Cell Biology. 151: 69-82. PMID 11018054 DOI: 10.1083/jcb.151.1.69  1
2000 Hampton RY. ER stress response: Getting the UPR hand on misfolded proteins Current Biology. 10. PMID 10898996 DOI: 10.1016/S0960-9822(00)00583-2  1
2000 Hampton RY. Cholesterol homeostasis: ESCAPe from the ER Current Biology. 10. PMID 10801406 DOI: 10.1016/S0960-9822(00)00434-6  1
2000 Cronin SR, Khoury A, Ferry DK, Hampton RY. Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. The Journal of Cell Biology. 148: 915-24. PMID 10704442 DOI: 10.1083/jcb.148.5.915  1
1999 Cronin SR, Hampton RY. Measuring protein degradation with green fluorescent protein. Methods in Enzymology. 302: 58-73. PMID 12876763  1
1999 Gardner RG, Hampton RY. A 'distributed degron' allows regulated entry into the ER degradation pathway Embo Journal. 18: 5994-6004. PMID 10545111 DOI: 10.1093/emboj/18.21.5994  1
1999 Gardner RG, Hampton RY. A highly conserved signal controls degradation of 3-hydroxy-3- methylglutaryl-coenzyme a (HMG-CoA) reductase in eukaryotes Journal of Biological Chemistry. 274: 31671-31678. PMID 10531376 DOI: 10.1074/jbc.274.44.31671  1
1998 Hampton RY. Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation Current Opinion in Lipidology. 9: 93-97. PMID 9559264 DOI: 10.1097/00041433-199804000-00003  1
1997 Hampton RY, Bhakta H. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase Proceedings of the National Academy of Sciences of the United States of America. 94: 12944-12948. PMID 9371780 DOI: 10.1073/pnas.94.24.12944  1
1997 Donald KAG, Hampton RY, Fritz IB. Effects of overproduction of the catalytic domain of 3-hydroxy-3- methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae Applied and Environmental Microbiology. 63: 3341-3344. PMID 9292983  1
1996 Hampton RY, Gardner RG, Rine J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3- methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein Molecular Biology of the Cell. 7: 2029-2044. PMID 8970163  1
1996 Hampton RY, Koning A, Wright R, Rine J. In vivo examination of membrane protein localization and degradation with green fluorescent protein Proceedings of the National Academy of Sciences of the United States of America. 93: 828-833. PMID 8570643 DOI: 10.1073/pnas.93.2.828  1
1994 Hampton RY, Rine J. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast Journal of Cell Biology. 125: 299-312. PMID 8163547  1
1992 Hampton RY, Raetz CRH. Lipid A 4'-kinase from Escherichia coli: Enzyme assay and preparation of 4'-32P-labeled probes of high specific radioactivity Methods in Enzymology. 209: 466-475. PMID 1323052 DOI: 10.1016/0076-6879(92)09057-A  1
1991 Hampton RY, Raetz CRH. Macrophage catabolism of lipid A is regulated by endotoxin stimulation Journal of Biological Chemistry. 266: 19499-19509. PMID 1918062  1
1991 Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CRH. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes Journal of Biological Chemistry. 266: 19490-19498. PMID 1918061  1
1991 Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CRH. Recognition and plasma clearance of endotoxin by scavenger receptors Nature. 352: 342-344. PMID 1852209 DOI: 10.1038/352342a0  1
1991 Hofer M, Hampton RY, Raetz CRH, Yu H. Aggregation behavior of lipid IVA in aqueous solutions at physiological pH. 1: Simple buffer solutions Chemistry and Physics of Lipids. 59: 167-181. PMID 1742809 DOI: 10.1016/0009-3084(91)90005-V  1
1990 Golenbock DT, Hampton RY, Raetz CRH, Wright SD. Human phagocytes have multiple lipid A-binding sites Infection and Immunity. 58: 4069-4075. PMID 1979320  1
1989 Hampton RY, Morand OH, Hannun YA. Sphingomyelin synthase and PKC activation Science. 246: 1050. PMID 2555921  1
1988 Hampton RY, Golenbock DT, Raetz CRH. Lipid A binding sites in membranes of macrophage tumor cells Journal of Biological Chemistry. 263: 14802-14807. PMID 3170565  1
1988 Raetz CRH, Brozek KA, Clementz T, Coleman JD, Galloway SM, Golenbock DT, Hampton RY. Gram-negative endotoxin: A biologically active lipid Cold Spring Harbor Symposia On Quantitative Biology. 53: 973-982. PMID 2474409 DOI: 10.1101/SQB.1988.053.01.112  1
1983 Hampton RY, Holz RW. Effects of changes in osmolality on the stability and function of cultured chromaffin cells and the possible role of osmotic forces in exocytosis. The Journal of Cell Biology. 96: 1082-8. PMID 6833392  1
1982 Bertalmio AJ, Herling S, Hampton RY, Winger G, Woods JH. A procedure for rapid evaluation of the discriminative stimulus effects of drugs Journal of Pharmacological Methods. 7: 289-299. PMID 7121010 DOI: 10.1016/0160-5402(82)90082-1  1
1982 Hampton RY, Medzihradsky F, Woods JH, Dahlstrom PJ. Stereospecific binding of 3H-phencyclidine in brain membranes Life Sciences. 30: 2147-2154. PMID 7109842 DOI: 10.1016/0024-3205(82)90288-0  1
1980 Hampton RY, Holz RW, Goldstein IJ. Phospholipid, glycolipid, and ion dependencies of concanavalin A- and Ricinus communis agglutinin I-induced agglutination of lipid vesicles. The Journal of Biological Chemistry. 255: 6766-71. PMID 7391048  1
1980 Hampton RY, Medzihradsky F, Woods JH. Stereospecific binding of phencyclidine in brain membranes Pharmacologist. 22.  1
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