Ashok S. Bhagwat - Publications

Affiliations: 
1988- Chemistry Wayne State University, Detroit, MI, United States 
Area:
Molecular Biology, Biochemistry

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Green AM, Landry S, Budagyan K, Avgousti D, Shalhout S, Bhagwat AS, Weitzman MD. APOBEC3A damages the cellular genome during DNA replication. Cell Cycle (Georgetown, Tex.). 0. PMID 26918916 DOI: 10.1080/15384101.2016.1152426  1
2016 Bhagwat AS, Hao W, Townes JP, Lee H, Tang H, Foster PL. Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 113: 2176-2181. DOI: 10.1073/pnas.1522325113/-/DCSupplemental  1
2015 Siriwardena SU, Guruge TA, Bhagwat AS. Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine. Journal of Molecular Biology. 427: 3042-55. PMID 26281709 DOI: 10.1016/j.jmb.2015.08.006  1
2015 Wei S, Shalhout S, Ahn YH, Bhagwat AS. A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair. Dna Repair. 27: 9-18. PMID 25616257 DOI: 10.1016/j.dnarep.2014.12.006  1
2014 Jinks-Robertson S, Bhagwat AS. Transcription-associated mutagenesis. Annual Review of Genetics. 48: 341-59. PMID 25251854 DOI: 10.1146/annurev-genet-120213-092015  1
2013 Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, ... ... Bhagwat AS, et al. The COMBREX project: design, methodology, and initial results. Plos Biology. 11: e1001638. PMID 24013487 DOI: 10.1371/journal.pbio.1001638  1
2012 Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. Plos Genetics. 8: e1003149. PMID 23271983 DOI: 10.1371/journal.pgen.1003149  1
2012 Hashimoto H, Hong S, Bhagwat AS, Zhang X, Cheng X. Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Research. 40: 10203-14. PMID 22962365 DOI: 10.1093/nar/gks845  1
2012 Wijesinghe P, Bhagwat AS. Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G. Nucleic Acids Research. 40: 9206-17. PMID 22798497 DOI: 10.1093/nar/gks685  1
2010 Bhagwat AS. Comment on "Deoxyuridine triphosphate incorporation during somatic hypermutation of mouse VkOx genes after immunization with phenyloxazolone". Journal of Immunology (Baltimore, Md. : 1950). 185: 7130-1; author reply. PMID 21127314 DOI: 10.4049/jimmunol.1090111  1
2010 Kuo HK, Krasich R, Bhagwat AS, Kreuzer KN. Importance of the tmRNA system for cell survival when transcription is blocked by DNA-protein cross-links. Molecular Microbiology. 78: 686-700. PMID 20807197 DOI: 10.1111/j.1365-2958.2010.07355.x  1
2010 Carpenter MA, Rajagurubandara E, Wijesinghe P, Bhagwat AS. Determinants of sequence-specificity within human AID and APOBEC3G. Dna Repair. 9: 579-87. PMID 20338830 DOI: 10.1016/j.dnarep.2010.02.010  1
2010 Betham B, Shalhout S, Marquez VE, Bhagwat AS. Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli. Dna Repair. 9: 153-60. PMID 20005183 DOI: 10.1016/j.dnarep.2009.11.006  1
2009 Canugovi C, Samaranayake M, Bhagwat AS. Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 34-44. PMID 18772346 DOI: 10.1096/fj.08-115352  1
2008 Szczepanowski RH, Carpenter MA, Czapinska H, Zaremba M, Tamulaitis G, Siksnys V, Bhagwat AS, Bochtler M. Central base pair flipping and discrimination by PspGI. Nucleic Acids Research. 36: 6109-17. PMID 18829716 DOI: 10.1093/nar/gkn622  1
2008 Carpenter MA, Bhagwat AS. DNA base flipping by both members of the PspGI restriction-modification system. Nucleic Acids Research. 36: 5417-25. PMID 18718929 DOI: 10.1093/nar/gkn528  1
2008 Fix D, Canugovi C, Bhagwat AS. Transcription increases methylmethane sulfonate-induced mutations in alkB strains of Escherichia coli. Dna Repair. 7: 1289-97. PMID 18515192 DOI: 10.1016/j.dnarep.2008.04.008  1
2008 Bhagwat AS, Carpenter MA, Bujnicki JM. Is AID a monomer in solution? Dna Repair. 7: 349-50; author reply. PMID 18187371 DOI: 10.1016/j.dnarep.2007.10.009  1
2007 Roy TW, Bhagwat AS. Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation. Nucleic Acids Research. 35: e147. PMID 18003660 DOI: 10.1093/nar/gkm1031  1
2006 Carpenter M, Divvela P, Pingoud V, Bujnicki J, Bhagwat AS. Sequence-dependent enhancement of hydrolytic deamination of cytosines in DNA by the restriction enzyme PspGI. Nucleic Acids Research. 34: 3762-70. PMID 16893959 DOI: 10.1093/nar/gkl545  1
2006 Samaranayake M, Bujnicki JM, Carpenter M, Bhagwat AS. Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair. Chemical Reviews. 106: 700-19. PMID 16464021 DOI: 10.1021/cr040496t  1
2005 Klapacz J, Bhagwat AS. Transcription promotes guanine to thymine mutations in the non-transcribed strand of an Escherichia coli gene. Dna Repair. 4: 806-13. PMID 15961353 DOI: 10.1016/j.dnarep.2005.04.017  1
2004 Bhagwat AS. DNA-cytosine deaminases: from antibody maturation to antiviral defense. Dna Repair. 3: 85-9. PMID 14697763 DOI: 10.1016/j.dnarep.2003.09.008  1
2003 Kurowski MA, Bhagwat AS, Papaj G, Bujnicki JM. Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB. Bmc Genomics. 4: 48. PMID 14667252 DOI: 10.1186/1471-2164-4-48  1
2003 Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Research. 31: 2990-4. PMID 12799424 DOI: 10.1093/nar/gkg464  1
2003 O'Neill RJ, Vorob'eva OV, Shahbakhti H, Zmuda E, Bhagwat AS, Baldwin GS. Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase? The Journal of Biological Chemistry. 278: 20526-32. PMID 12668677 DOI: 10.1074/jbc.M210860200  1
2003 Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Research. 31: 1805-12. PMID 12654995 DOI: 10.1093/nar/gkg274  1
2003 Wu P, Qiu C, Sohail A, Zhang X, Bhagwat AS, Cheng X. Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. The Journal of Biological Chemistry. 278: 5285-91. PMID 12456671 DOI: 10.1074/jbc.M210884200  1
2002 Klapacz J, Bhagwat AS. Transcription-dependent increase in multiple classes of base substitution mutations in Escherichia coli. Journal of Bacteriology. 184: 6866-72. PMID 12446637 DOI: 10.1128/JB.184.24.6866-6872.2002  1
2002 Mokkapati SK, Bhagwat AS. Lack of dependance of transcription-induced cytosine deaminations on protein synthesis. Mutation Research. 508: 131-6. PMID 12379468 DOI: 10.1016/S0027-5107(02)00192-6  1
2002 Sohail A, Hayes CS, Divvela P, Setlow P, Bhagwat AS. Protection of DNA by alpha/beta-type small, acid-soluble proteins from Bacillus subtilis spores against cytosine deamination. Biochemistry. 41: 11325-30. PMID 12234173 DOI: 10.1021/bi026332t  1
2002 Bhagwat AS, Lieb M. Cooperation and competition in mismatch repair: very short-patch repair and methyl-directed mismatch repair in Escherichia coli. Molecular Microbiology. 44: 1421-8. PMID 12067333 DOI: 10.1046/j.1365-2958.2002.02989.x  1
2001 Beletskii A, Bhagwat AS. Transcription-induced cytosine-to-thymine mutations are not dependent on sequence context of the target cytosine. Journal of Bacteriology. 183: 6491-3. PMID 11591695 DOI: 10.1128/JB.183.21.6491-6493.2001  1
2001 Lieb M, Rehmat S, Bhagwat AS. Interaction of MutS and Vsr: Some dominant-negative mutS mutations that disable methyladenine-directed mismatch repair are active in very-short-patch repair Journal of Bacteriology. 183: 6487-6490. PMID 11591694 DOI: 10.1128/JB.183.21.6487-6490.2001  1
2001 Mokkapati SK, Fernández De Henestrosa AR, Bhagwat AS. Escherichia coli DNA glycosylase Mug: A growth-regulated enzyme required for mutation avoidance in stationary-phase cells Molecular Microbiology. 41: 1101-1111. PMID 11555290 DOI: 10.1046/j.1365-2958.2001.02559.x  1
2000 Sharath AN, Weinhold E, Bhagwat AS. Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. Biochemistry. 39: 14611-6. PMID 11087417 DOI: 10.1021/bi001610e  1
2000 Beletskii A, Grigoriev A, Joyce S, Bhagwat AS. Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome. Journal of Molecular Biology. 300: 1057-65. PMID 10903854 DOI: 10.1006/jmbi.2000.3944  1
1999 Lutsenko E, Bhagwat AS. The role of the Escherichia coli mug protein in the removal of uracil and 3,N4-ethenocytosine from DNA Journal of Biological Chemistry. 274: 31034-31038. PMID 10521502 DOI: 10.1074/jbc.274.43.31034  1
1999 Bhagwat AS, Sanderson RJ, Lindahl T. Delayed DNA joining at 3' mismatches by human DNA ligases Nucleic Acids Research. 27: 4028-4033. PMID 10497267 DOI: 10.1093/nar/27.20.4028  1
1999 Lutsenko E, Bhagwat AS. Principal causes of hot spots for cytosine to thymine mutations at sites of cytosine methylation in growing cellsA model, its experimental support and implications Mutation Research - Reviews in Mutation Research. 437: 11-20. PMID 10425387 DOI: 10.1016/S1383-5742(99)00065-4  1
1998 Beletskii A, Bhagwat AS. Correlation between transcription and C to T mutations in the non-transcribed DNA strand. Biological Chemistry. 379: 549-51. PMID 9628351  1
1997 Sheluho D, Yebra MJ, Khariwala SS, Bhagwat AS. Lack of correlation between binding of EcoRII methyltransferase to DNA duplexes containing mismatches and the promotion of C to T mutations Molecular and General Genetics. 255: 54-59. PMID 9230899 DOI: 10.1007/s004380050474  1
1996 Beletskii A, Bhagwat AS. Transcription-induced mutations: increase in C to T mutations in the nontranscribed strand during transcription in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 93: 13919-24. PMID 8943036 DOI: 10.1073/pnas.93.24.13919  1
1996 Lieb M, Bhagwat AS. Very short patch repair: Reducing the cost of cytosine methylation Molecular Microbiology. 20: 467-473. PMID 8736526  1
1996 Bandaru B, Gopal J, Bhagwat AS. Overproduction of DNA cytosine methyltransferases causes methylation and C → T mutations at non-canonical sites Journal of Biological Chemistry. 271: 7851-7859. PMID 8631830 DOI: 10.1074/jbc.271.13.7851  1
1996 Bhagwat AS, Beletskii A. Transcription is intrinsically mutagenic: Direct correlation between transcription and c to u or 5mec to t deaminations in the non-transcribed strand Faseb Journal. 10.  1
1996 Sheluho D, Khariwala S, Yebra MJ, Bhagwat AS. Ability of cytosine methyltransferases to bind substrates containing mismatches is not sufficient for causing c to t mutations Faseb Journal. 10.  1
1995 Gopal J, Bhagwat AS. Determination of methylation specificity of DsaV methyltransferase by a simple biochemical method Nucleic Acids Research. 23: 29-35. PMID 7870587 DOI: 10.1093/nar/23.1.29  1
1995 Bandaru B, Wyszynski M, Bhagwat AS. HpaII methyltransferase is mutagenic in Escherichia coli Journal of Bacteriology. 177: 2950-2952. PMID 7751315  1
1995 Gopal J, Yebra MJ, Bhagwat AS. Cloning and characterization of the gene encoding the DsaV methyltransferase Gene. 157: 61-63. PMID 7607527 DOI: 10.1016/0378-1119(94)00628-6  1
1995 Yebra MJ, Bhagwat AS. A novel repetitive sequence lies near the gene encoding a cytosine methyltransferase in the cyanobacterium Dactylococcopsis salina Gene. 164: 71-74. PMID 7590324 DOI: 10.1016/0378-1119(95)00516-9  1
1995 Yebra MJ, Bhagwat AS. A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine Biochemistry. 34: 14752-14757. PMID 7578083  1
1995 Gabbara S, Bhagwat AS. The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor Biochemical Journal. 307: 87-92. PMID 7536414  1
1995 Bestor TH, Bhagwat AS, Blumenthal RM, Brooks JE, Marinus MG, Raleigh EA, Szybalski W. Preface of the proceedings to the third New England biolabs workshop on biological DNA modification Gene. 157: xi.  1
1994 Gabbara S, Wyszynski M, Bhagwat AS. A DNA repair process in Escherichia coli corrects U:G and T:G mismatches to C:G at sites of cytosine methylation Mgg Molecular &Amp; General Genetics. 243: 244-248. PMID 8177221 DOI: 10.1007/BF00280322  1
1994 Wyszynski M, Gabbara S, Bhagwat AS. Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 91: 1574-1578. PMID 8108447  1
1994 Gopal J, Yebra MJ, Bhagwat AS. Dsav methyltransferase and its isoschizomers contain a conserved segment that is similar to the segment in hhal methyltransferase that is in contact with DNA bases Nucleic Acids Research. 22: 4482-4488. PMID 7971279 DOI: 10.1093/nar/22.21.4482  1
1993 Wyszynski MW, Gabbara S, Kubareva EA, Romanova EA, Oretskaya TS, Gromova ES, Shabarova ZA, Bhagwat AS. The cysteine conserved among DNA cytosine methylasesis required for methyl transfer, but not for specific DNA binding Nucleic Acids Research. 21: 295-301. PMID 8441637 DOI: 10.1093/nar/21.2.295  1
1993 Dar ME, Bhagwat AS. Mechanism of expression of DNA repair gene vsr, an Escherichia coli gene that overlaps the DNA cytosine methylase gene, dcm Molecular Microbiology. 9: 823-833. PMID 7694036  1
1992 Bhagwat AS, Mcclelland M. DNA mismatch correction by very short patch repair may have altered the abundance of oligonucleotides in the E. coli genome Nucleic Acids Research. 20: 1663-1668. PMID 1579457 DOI: 10.1093/nar/20.7.1663  1
1992 McClelland M, Bhagwat AS. Biased DNA repair [9] Nature. 355: 595-596. PMID 1538746  1
1992 Gabbara S, Bhagwat AS. Interaction of EcoRII endonuclease with DNA substrates containing single recognition sites Journal of Biological Chemistry. 267: 18623-18630. PMID 1526995  1
1992 Wyszynski MW, Gabbara S, Bhagwat AS. Substitutions of a cysteine conserved among DNA cytosine methylases result in a variety of phenotypes Nucleic Acids Research. 20: 319-326. PMID 1371346 DOI: 10.1093/nar/20.2.319  1
1992 Bhagwat AS. [21] Restriction enzymes: Properties and use Methods in Enzymology. 216: 199-224. PMID 1336091 DOI: 10.1016/0076-6879(92)16023-D  1
1990 Sohail A, Lieb M, Dar M, Bhagwat AS. A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene Journal of Bacteriology. 172: 4214-4221. PMID 2198248  1
1990 Bhagwat AS, Johnson B, Weule K, Roberts RJ. Primary sequence of the EcoRII endonuclease and properties of its fusions with β-galactosidase Journal of Biological Chemistry. 265: 767-773. PMID 2104830  1
1989 Pósfai J, Bhagwat AS, Pósfai G, Roberts RJ. Predictive motifs derived from cytosine methyltransferases Nucleic Acids Research. 17: 2421-2435. PMID 2717398 DOI: 10.1093/nar/17.7.2421  1
1988 Posfai J, Bhagwat AS, Roberts RJ. Sequence motifs specific for cytosine methyltransferases Gene. 74: 261-265. PMID 3248729 DOI: 10.1016/0378-1119(88)90299-5  1
1988 Bhagwat AS, Sohail A, Lieb M. A new gene involved in mismatch correction in Escherichia coli Gene. 74: 153-156. PMID 3074004 DOI: 10.1016/0378-1119(88)90274-0  1
1988 Lieb M, Bhagwat AS. Very short patch mismatch repair activity associated with gene dcm is not conferred by a plasmid coding for EcoRII methylase Journal of Bacteriology. 170: 4967-4968. PMID 3049557  1
1987 Som S, Bhagwat AS, Friedman S. Nucleotide sequence and expression of the gene encoding the EcoRII modification enzyme Nucleic Acids Research. 15: 313-332. PMID 3029675 DOI: 10.1093/nar/15.1.313  1
1987 Bhagwat AS, Roberts RJ. Genetic analysis of the 5-azacytidine sensitivity of Escherichia coli K-12 Journal of Bacteriology. 169: 1537-1546. PMID 2435706  1
1986 Bhagwat AS, Sohail A, Roberts RJ. Cloning and characterization of the dcm locus of Escherichia coli K-12 Journal of Bacteriology. 166: 751-755. PMID 3011742  1
1981 Bhagwat AS, Person S. Structure and properties of the region of homology between plasmids pMB1 and ColE1 Mgg Molecular &Amp; General Genetics. 182: 505-507. PMID 6946274 DOI: 10.1007/BF00293943  1
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