F Peter Guengerich - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Biochemistry

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Year Citation  Score
2017 Marsch GA, Carlson BT, Guengerich FP. 7,8-Benzoflavone Binding to Human Cytochrome P450 3A4 Reveals Complex Fluorescence Quenching, Suggesting Binding at Multiple Protein Sites. Journal of Biomolecular Structure & Dynamics. 1-74. PMID 28278026 DOI: 10.1080/07391102.2017.1301270  0.36
2016 Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP. Mechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1. 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. The Journal of Biological Chemistry. 291: 26587. PMID 27986869 DOI: 10.1074/jbc.A116.732966  0.32
2016 Yoshimoto FK, Jung IJ, Goyal S, Guengerich FP, Gonzalez E. Isotope-Labeling Studies Support an Electrophilic Compound I Iron Active Species (FeO3+) for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side Chain Cleavage Enzyme, Cytochrome P450 11A1 (P450SCC). Journal of the American Chemical Society. PMID 27571509 DOI: 10.1021/jacs.6b04437  1
2016 Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong HL, Guengerich FP, Liebler DC. Specificity of protein covalent modification by the electrophilic proteasome inhibitor carfilzomib in human cells. Molecular & Cellular Proteomics : McP. PMID 27503896 DOI: 10.1074/mcp.M116.059709  0.32
2016 Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP. Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-chromosome or Hepatocytes by Two-dimensional Electrophoresis/Accelerator Mass Spectrometry. Chemical Research in Toxicology. PMID 27464947 DOI: 10.1021/acs.chemrestox.6b00210  0.44
2016 Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP. Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1. 18O-Labeling and Oxygen Surrogate Evidence for a Role of a Perferryl Oxygen. The Journal of Biological Chemistry. PMID 27339894 DOI: 10.1074/jbc.M116.732966  1
2016 Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP. Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, And Physiologically-Based Pharmacokinetic Modeling in Toxicology. Chemical Research in Toxicology. PMID 27337115 DOI: 10.1021/acs.chemrestox.6b00136  0.44
2016 Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D. Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. Scientific Reports. 6: 28462. PMID 27334049 DOI: 10.1038/srep28462  1
2016 Savas U, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF. 20-Hydroxyeicosatetraenoic Acid (HETE) Dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of Blood Pressure by Sodium Restriction, Hydrochlorothiazide, or Blockade of the Type 1 Angiotensin II Receptor. The Journal of Biological Chemistry. PMID 27298316 DOI: 10.1074/jbc.M116.732297  1
2016 Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M. Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. The Journal of Biological Chemistry. PMID 27226627 DOI: 10.1074/jbc.M116.732487  1
2016 Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and their Alkynyl Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. PMID 27137136 DOI: 10.1021/acs.chemrestox.6b00083  0.96
2016 Humphreys WG, Will Y, Guengerich FP. Toxicology Strategies for Drug Discovery - Present and Future: Introduction. Chemical Research in Toxicology. 29: 437. PMID 27087588 DOI: 10.1021/acs.chemrestox.6b00049  0.6
2016 Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP. Human Cytochrome P450 27C1 Catalyzes 3,4-Desaturation of Retinoids. Febs Letters. PMID 27059013 DOI: 10.1002/1873-3468.12167  1
2016 Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chemical Research in Toxicology. PMID 26914252 DOI: 10.1021/acs.chemrestox.5b00513  1
2015 Xue Q, Zhong M, Liu B, Tang Y, Wei Z, Guengerich FP, Zhang H. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. Biochimie. PMID 26700143 DOI: 10.1016/j.biochi.2015.12.009  1
2015 O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ. Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. Biochemistry. 54: 7449-56. PMID 26624500 DOI: 10.1021/acs.biochem.5b01078  1
2015 Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, et al. Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Current Biology : Cb. PMID 26549260 DOI: 10.1016/j.cub.2015.10.018  0.56
2015 Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H. Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice. Chemical Research in Toxicology. PMID 26492539 DOI: 10.1021/acs.chemrestox.5b00381  1
2015 Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-14. PMID 26247835 DOI: 10.3109/00498254.2015.1069419  1
2015 Kramlinger VM, Alvarado Rojas M, Kanamori T, Guengerich FP. Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis. The Journal of Biological Chemistry. 290: 20200-10. PMID 26157146 DOI: 10.1074/jbc.M115.665331  1
2015 Guengerich FP. Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases. The Journal of Biological Chemistry. 290: 20700-1. PMID 26152720 DOI: 10.1074/jbc.R115.675652  1
2015 Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY. Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Chemical Research in Toxicology. 28: 1496-507. PMID 26098310 DOI: 10.1021/acs.chemrestox.5b00166  1
2015 Guengerich FP. Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE. The Journal of Biological Chemistry. 290: 18943-4. PMID 26055725 DOI: 10.1074/jbc.R115.670265  1
2015 Su Y, Patra A, Harp JM, Egli M, Guengerich FP. Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. The Journal of Biological Chemistry. 290: 15921-33. PMID 25947374 DOI: 10.1074/jbc.M115.653691  1
2015 Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. The Journal of Biological Chemistry. 290: 13128-43. PMID 25855791 DOI: 10.1074/jbc.M115.646307  1
2015 Boji? M, Sedgeman CA, Nagy LD, Guengerich FP. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 73: 49-56. PMID 25840124 DOI: 10.1016/j.ejps.2015.03.015  1
2015 Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, et al. Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo. Nucleic Acids Research. 43: 5489-500. PMID 25837992 DOI: 10.1093/nar/gkv243  1
2015 Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B. Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Dna Repair. 30: 1-10. PMID 25797601 DOI: 10.1016/j.dnarep.2015.02.021  1
2015 Chowdhury G, Guengerich FP. Characterization of thioether-linked protein adducts of DNA using a raney-ni-mediated desulfurization method and liquid chromatography-electrospray-tandem mass spectrometry. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 60: 10.15.1-10.15.14. PMID 25754888 DOI: 10.1002/0471142700.nc1015s60  1
2015 Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP. Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. The Journal of Biological Chemistry. 290: 8028-38. PMID 25666608 DOI: 10.1074/jbc.M115.637561  1
2015 Shimada T, Takenaka S, Murayama N, Yamazaki H, Kim JH, Kim D, Yoshimoto FK, Guengerich FP, Komori M. Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology. PMID 25642975 DOI: 10.1021/tx500505y  1
2015 Lajovic A, Nagy LD, Guengerich FP, Bren U. Carcinogenesis of urethane: simulation versus experiment. Chemical Research in Toxicology. 28: 691-701. PMID 25642734 DOI: 10.1021/tx500459t  1
2015 Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. The Journal of Biological Chemistry. 290: 3248-68. PMID 25533464 DOI: 10.1074/jbc.M114.627265  1
2015 Rendic S, Guengerich FP. Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. Chemical Research in Toxicology. 28: 38-42. PMID 25485457 DOI: 10.1021/tx500444e  1
2015 Guengerich FP. Human cytochrome P450 enzymes Cytochrome P450: Structure, Mechanism, and Biochemistry, Fourth Edition. 523-785. DOI: 10.1007/978-3-319-12108-6_9  1
2014 Yoshimoto FK, Guengerich FP. Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Journal of the American Chemical Society. 136: 15016-25. PMID 25252141 DOI: 10.1021/ja508185d  1
2014 Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Biochemistry. 53: 6161-72. PMID 25203493 DOI: 10.1021/bi500710e  1
2014 Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chemical Research in Toxicology. 27: 1837-52. PMID 25162224 DOI: 10.1021/tx5002755  1
2014 Guengerich FP. Thematic minireview series: metals in biology 2014. The Journal of Biological Chemistry. 289: 28094. PMID 25160633 DOI: 10.1074/jbc.R114.607093  1
2014 Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. The Journal of Biological Chemistry. 289: 29614-30. PMID 25160618 DOI: 10.1074/jbc.M114.583062  1
2014 Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. The Febs Journal. 281: 4394-410. PMID 25065501 DOI: 10.1111/febs.12947  1
2014 Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. Journal of Lipid Research. 55: 1933-43. PMID 25017465 DOI: 10.1194/jlr.M051508  1
2014 Patra A, Nagy LD, Zhang Q, Su Y, Müller L, Guengerich FP, Egli M. Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. The Journal of Biological Chemistry. 289: 16867-82. PMID 24759104 DOI: 10.1074/jbc.M114.551820  1
2014 Song I, Kim EJ, Kim IH, Park EM, Lee KE, Shin JH, Guengerich FP, Choi JY. Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. Chemical Research in Toxicology. 27: 919-30. PMID 24725253 DOI: 10.1021/tx500072m  0.96
2014 Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S, Guengerich FP. Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. The Journal of Biological Chemistry. 289: 10476-87. PMID 24563460 DOI: 10.1074/jbc.M114.550004  0.32
2014 Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG. Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. The Journal of Biological Chemistry. 289: 9936-51. PMID 24497629 DOI: 10.1074/jbc.M113.525659  0.36
2014 Murayama N, van Beuningen R, Suemizu H, Guguen-Guillouzo C, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H. Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chemical Research in Toxicology. 27: 304-8. PMID 24460184 DOI: 10.1021/tx4004374  1
2014 Chowdhury G, Shibata N, Yamazaki H, Guengerich FP. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. Chemical Research in Toxicology. 27: 147-56. PMID 24350712 DOI: 10.1021/tx4004215  1
2014 Guengerich FP. Cytochrome P450 Enzymes Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.01960-7  1
2014 Guengerich FP. Fifty years of progress in drug metabolism and toxicology: What do we still need to know about cytochrome P450 enzymes? Fifty Years of Cytochrome P450 Research. 17-42. DOI: 10.1007/978-4-431-54992-5_2  1
2014 Guengerich FP. Experimental Approaches to Analysis of Reactions of Cytochrome P450 Enzymes Drug Metabolism Prediction. 199-220. DOI: 10.1002/9783527673261.ch08  1
2014 Guengerich FP. Cytochrome P450-Mediated Drug Interaction and Cardiovascular Safety: The Seldane to Allegra Transformation Predictive Admet: Integrated Approaches in Drug Discovery and Development. 523-534. DOI: 10.1002/9781118783344.ch23  1
2013 Guengerich FP. Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions. Journal of Labelled Compounds & Radiopharmaceuticals. 56: 428-31. PMID 24285515 DOI: 10.1002/jlcr.3031  1
2013 Cho SH, Guengerich FP. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. Chemical Research in Toxicology. 26: 1765-74. PMID 24191644 DOI: 10.1021/tx4003534  0.88
2013 Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Biochemistry. 52: 8766-76. PMID 24171480 DOI: 10.1021/bi401103k  1
2013 Chowdhury G, Cho SH, Pegg AE, Guengerich FP. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Angewandte Chemie (International Ed. in English). 52: 12879-82. PMID 24130045 DOI: 10.1002/anie.201307580  1
2013 Stornetta A, Angelov T, Guengerich FP, Sturla SJ. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Chembiochem : a European Journal of Chemical Biology. 14: 1634-9. PMID 23959784 DOI: 10.1002/cbic.201300296  1
2013 Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochemical Pharmacology. 86: 548-60. PMID 23792120 DOI: 10.1016/j.bcp.2013.06.006  0.56
2013 Cho SH, Guengerich FP. Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases. Chemical Research in Toxicology. 26: 1005-13. PMID 23701509 DOI: 10.1021/tx400145e  1
2013 Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. The Journal of Toxicological Sciences. 38: 349-54. PMID 23665933 DOI: DN/JST.JSTAGE/jts/38.349  1
2013 Guengerich FP, Munro AW. Unusual cytochrome p450 enzymes and reactions. The Journal of Biological Chemistry. 288: 17065-73. PMID 23632016 DOI: 10.1074/jbc.R113.462275  1
2013 Guengerich FP. New trends in cytochrome p450 research at the half-century mark. The Journal of Biological Chemistry. 288: 17063-4. PMID 23632015 DOI: 10.1074/jbc.R113.466821  1
2013 Guengerich FP. Thematic minireview series: metals in biology 2013. The Journal of Biological Chemistry. 288: 13164. PMID 23539620 DOI: 10.1074/jbc.R113.467712  1
2013 Akiyoshi T, Ito M, Murase S, Miyazaki M, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. Drug Metabolism and Pharmacokinetics. 28: 411-5. PMID 23514827 DOI: DN/JST.JSTAGE/dmpk/DMPK-12-RG-134  0.36
2013 Cheng Q, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Methods in Molecular Biology (Clifton, N.J.). 987: 157-62. PMID 23475676 DOI: 10.1007/978-1-62703-321-3_14  1
2013 Cheng Q, Guengerich FP. Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches. Methods in Molecular Biology (Clifton, N.J.). 987: 71-7. PMID 23475668 DOI: 10.1007/978-1-62703-321-3_6  1
2013 Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG. Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. The Journal of Biological Chemistry. 288: 12627-44. PMID 23471973 DOI: 10.1074/jbc.M113.452367  0.44
2013 Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP. Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. Chemical Research in Toxicology. 26: 529-37. PMID 23432465 DOI: 10.1021/tx3004906  1
2013 Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Chemical Research in Toxicology. 26: 517-28. PMID 23432429 DOI: 10.1021/tx300492j  1
2013 Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. Chemical Research in Toxicology. 26: 486-9. PMID 23419139 DOI: 10.1021/tx400008g  1
2013 Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP. Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. Archives of Biochemistry and Biophysics. 530: 101-7. PMID 23357279 DOI: 10.1016/j.abb.2013.01.001  0.52
2013 Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. The Journal of Biological Chemistry. 288: 4436-51. PMID 23258538 DOI: 10.1074/jbc.M112.402123  1
2013 Guengerich FP. Cytochrome P450 activation of toxins and hepatotoxicity Drug-Induced Liver Disease. 15-33. DOI: 10.1016/B978-0-12-387817-5.00002-9  1
2012 Chowdhury G, Calcutt MW, Nagy LD, Guengerich FP. Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Biochemistry. 51: 9995-10007. PMID 23186213 DOI: 10.1021/bi301092c  1
2012 Kotapati S, Maddukuri L, Wickramaratne S, Seneviratne U, Goggin M, Pence MG, Villalta P, Guengerich FP, Marnett L, Tretyakova N. Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. The Journal of Biological Chemistry. 287: 38800-11. PMID 22977231 DOI: 10.1074/jbc.M112.396788  1
2012 Zhao L, Pence MG, Christov PP, Wawrzak Z, Choi JY, Rizzo CJ, Egli M, Guengerich FP. Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases. The Journal of Biological Chemistry. 287: 35516-26. PMID 22910910 DOI: 10.1074/jbc.M112.403253  1
2012 Lim S, Song I, Guengerich FP, Choi JY. Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). Chemical Research in Toxicology. 25: 1699-707. PMID 22793782 DOI: 10.1021/tx300168p  0.96
2012 Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP. Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. The Journal of Biological Chemistry. 287: 29554-67. PMID 22773874 DOI: 10.1074/jbc.M112.390047  1
2012 Wang K, Guengerich FP. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. Chemical Research in Toxicology. 25: 1740-51. PMID 22734839 DOI: 10.1021/tx3001994  1
2012 Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Chemical Research in Toxicology. 25: 1652-61. PMID 22721435 DOI: 10.1021/tx300113e  1
2012 Cho SH, Guengerich FP. Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. Chemical Research in Toxicology. 25: 1522-30. PMID 22670845 DOI: 10.1021/tx3002109  0.88
2012 Rendic S, Guengerich FP. Contributions of human enzymes in carcinogen metabolism. Chemical Research in Toxicology. 25: 1316-83. PMID 22531028 DOI: 10.1021/tx300132k  1
2012 Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP. Replication of N2,3-ethenoguanine by DNA polymerases. Angewandte Chemie (International Ed. in English). 51: 5466-9. PMID 22488769 DOI: 10.1002/anie.201109004  1
2012 Guengerich FP. Thematic minireview series: Metals in Biology 2012. The Journal of Biological Chemistry. 287: 13508-9. PMID 22389507 DOI: 10.1074/jbc.R112.355933  1
2012 Guengerich FP. Introduction: use of radioactive compounds in drug discovery and development. Chemical Research in Toxicology. 25: 511-2. PMID 22324508 DOI: 10.1021/tx3000522  1
2012 Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Chemical Research in Toxicology. 25: 274-6. PMID 22268628 DOI: 10.1021/tx300009j  1
2012 Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR. Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. The Journal of Biological Chemistry. 287: 10613-22. PMID 22262854 DOI: 10.1074/jbc.M111.323501  1
2012 Cho SH, Guengerich FP. Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. Chemical Research in Toxicology. 25: 706-12. PMID 22181695 DOI: 10.1021/tx200471x  1
2011 Chowdhury G, Guengerich FP. Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 7.16.1-11. PMID 22147421 DOI: 10.1002/0471142700.nc0716s47  1
2011 Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. The Journal of Biological Chemistry. 286: 33021-8. PMID 21813643 DOI: 10.1074/jbc.M111.282434  1
2011 Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. The Journal of Biological Chemistry. 286: 31180-93. PMID 21784862 DOI: 10.1074/jbc.M111.258038  1
2011 Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA. Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. Chemical Research in Toxicology. 24: 1223-30. PMID 21766881 DOI: 10.1021/tx200080b  1
2011 Guengerich FP, Cheng Q. Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology. Pharmacological Reviews. 63: 684-99. PMID 21737533 DOI: 10.1124/pr.110.003525  0.52
2011 Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M. Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. Chemical Research in Toxicology. 24: 1327-37. PMID 21732699 DOI: 10.1021/tx200218u  1
2011 Guengerich FP. Thematic minireview series on biological applications of mass spectrometry. The Journal of Biological Chemistry. 286: 25417. PMID 21632545 DOI: 10.1074/jbc.R111.266700  1
2011 Guengerich FP. Guest editor's introduction. Special issue on catalytic mechanisms. Archives of Biochemistry and Biophysics. 507: 1-2. PMID 21324387 DOI: 10.1016/j.abb.2011.01.026  1
2011 Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chemical Research in Toxicology. 24: 287-9. PMID 21299192 DOI: 10.1021/tx200005g  1
2011 Akiyoshi T, Saito T, Murase S, Miyazaki M, Murayama N, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H. Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 724-8. PMID 21212239 DOI: 10.1124/dmd.110.036780  1
2011 Guengerich FP, Sohl CD, Chowdhury G. Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Archives of Biochemistry and Biophysics. 507: 126-34. PMID 20804723 DOI: 10.1016/j.abb.2010.08.017  1
2010 Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chemical Research in Toxicology. 23: 1921-35. PMID 21053930 DOI: 10.1021/tx100286d  1
2010 Cheng Q, Lamb DC, Kelly SL, Lei L, Guengerich FP. Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction. Journal of the American Chemical Society. 132: 15173-5. PMID 20979426 DOI: 10.1021/ja107801v  0.52
2010 Pence MG, Choi JY, Egli M, Guengerich FP. Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. The Journal of Biological Chemistry. 285: 40666-72. PMID 20961860 DOI: 10.1074/jbc.M110.183665  0.36
2010 Eoff RL, Choi JY, Guengerich FP. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Journal of Nucleic Acids. 2010. PMID 20936119 DOI: 10.4061/2010/830473  1
2010 Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. Journal of Molecular Biology. 404: 34-44. PMID 20888339 DOI: 10.1016/j.jmb.2010.09.015  0.96
2010 Cho SH, Loecken EM, Guengerich FP. Mutagenicity of a glutathione conjugate of butadiene diepoxide. Chemical Research in Toxicology. 23: 1544-6. PMID 20879737 DOI: 10.1021/tx100304f  1
2010 Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1013-8. PMID 20823515 DOI: 10.1107/S1744309110029374  1
2010 Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Angewandte Chemie (International Ed. in English). 49: 7481-5. PMID 20814997 DOI: 10.1002/anie.201003168  1
2010 Tang Z, Guengerich FP. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Analytical Chemistry. 82: 7706-12. PMID 20795636 DOI: 10.1021/ac1015497  1
2010 Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 49: 8415-24. PMID 20726503 DOI: 10.1021/bi1009024  1
2010 Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ. Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chemical Research in Toxicology. 23: 1330-41. PMID 20578729 DOI: 10.1021/tx100082e  1
2010 Guengerich FP. Thematic minireview series: Metals in biology 2010 Journal of Biological Chemistry. 285: 26727. PMID 20522544 DOI: 10.1074/jbc.R110.150870  1
2010 Sohl CD, Guengerich FP. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. The Journal of Biological Chemistry. 285: 17734-43. PMID 20385561 DOI: 10.1074/jbc.M110.123711  1
2010 Rendic S, Guengerich FP. Update information on drug metabolism systems - 2009, Part II. Summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters Current Drug Metabolism. 11: 4-84. PMID 20302566 DOI: 10.2174/138920010791110917  1
2010 Zhang H, Guengerich FP. Effect of N2-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W Journal of Molecular Biology. 395: 1007-1018. PMID 19969000 DOI: 10.1016/j.jmb.2009.11.071  1
2009 Guengerich FP. Cataloging the Repertoire of Nature's Blowtorch, P450 Chemistry and Biology. 16: 1215-1216. PMID 20064429 DOI: 10.1016/j.chembiol.2009.12.002  1
2009 Zhang H, Beckman JW, Guengerich FP. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation Journal of Biological Chemistry. 284: 35144-35153. PMID 19837980 DOI: 10.1074/jbc.M109.067397  1
2009 Deweese JE, Guengerich FP, Burgin AB, Osheroff N. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry. 48: 8940-7. PMID 19697956 DOI: 10.1021/bi900875c  1
2009 Cheng Q, Sohl CD, Guengerich FP. High-throughput fluorescence assay of cytochrome P450 3A4. Nature Protocols. 4: 1258-61. PMID 19661996 DOI: 10.1038/nprot.2009.123  1
2009 Sohl CD, Cheng Q, Guengerich FP. Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Nature Protocols. 4: 1252-7. PMID 19661995 DOI: 10.1038/nprot.2009.122  1
2009 Guengerich FP, Martin MV, Sohl CD, Cheng Q. Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Nature Protocols. 4: 1245-51. PMID 19661994 DOI: 10.1038/nprot.2009.121  1
2009 Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP. Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis Journal of Biological Chemistry. 284: 24425-24431. PMID 19561069 DOI: 10.1074/jbc.M109.011320  1
2009 Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP. Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. The Journal of Biological Chemistry. 284: 18434-44. PMID 19419958 DOI: 10.1074/jbc.M109.012542  1
2009 Loecken EM, Dasari S, Hill S, Tabb DL, Guengerich FP. The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. Chemical Research in Toxicology. 22: 1069-76. PMID 19364102 DOI: 10.1021/tx900037u  1
2009 Guengerich FP. Introduction: Human metabolites in safety testing (MIST) issue Chemical Research in Toxicology. 22: 237-238. PMID 19216576 DOI: 10.1021/tx900003k  1
2009 Knutson CG, Rubinson EH, Akingbade D, Anderson CS, Stec DF, Petrova KV, Kozekov ID, Guengerich FP, Rizzo CJ, Marnett LJ. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Biochemistry. 48: 800-9. PMID 19132922 DOI: 10.1021/bi801654j  1
2009 Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. The Journal of Biological Chemistry. 284: 3563-76. PMID 19059910 DOI: 10.1074/jbc.M807778200  1
2008 Beckman JW, Wang Q, Guengerich FP. Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. The Journal of Biological Chemistry. 283: 36711-23. PMID 18984592 DOI: 10.1074/jbc.M806785200  1
2008 Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 47: 10892-903. PMID 18803403 DOI: 10.1021/bi8008664  1
2008 Isin EM, Guengerich FP. Substrate binding to cytochromes P450 Analytical and Bioanalytical Chemistry. 392: 1019-1030. PMID 18622598 DOI: 10.1007/s00216-008-2244-0  1
2008 Choi JY, Guengerich FP. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1 Journal of Biological Chemistry. 283: 23645-23655. PMID 18591245 DOI: 10.1074/jbc.M801686200  1
2008 Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. The Journal of Biological Chemistry. 283: 17147-57. PMID 18442974 DOI: 10.1074/jbc.M802447200  1
2008 Isin EM, Sohl CD, Eoff RL, Guengerich FP. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Archives of Biochemistry and Biophysics. 473: 69-75. PMID 18328798 DOI: 10.1016/j.abb.2008.02.033  1
2008 Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. The Journal of Biological Chemistry. 283: 7293-308. PMID 18187423 DOI: 10.1074/jbc.M709783200  1
2008 Loecken EM, Guengerich FP. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Chemical Research in Toxicology. 21: 453-8. PMID 18163542 DOI: 10.1021/tx7003618  1
2008 Guengerich FP. Cytochrome P450 and chemical toxicology Chemical Research in Toxicology. 21: 70-83. PMID 18052394 DOI: 10.1021/tx700079z  1
2008 Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH. Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. Protein Expression and Purification. 57: 188-200. PMID 18032064 DOI: 10.1016/j.pep.2007.10.010  1
2008 Chowdhury G, Guengerich FP. Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry Angewandte Chemie - International Edition. 47: 381-384. PMID 18022988 DOI: 10.1002/anie.200703942  1
2008 Guengerich FP, Isin EM. Mechanisms of cytochrome P450 reactions Acta Chimica Slovenica. 55: 7-19.  1
2007 Guengerich FP. Mechanisms of cytochrome P450 substrate oxidation: MiniReview Journal of Biochemical and Molecular Toxicology. 21: 163-168. PMID 17936929 DOI: 10.1002/jbt.20174  1
2007 Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP. Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). The Journal of Biological Chemistry. 282: 17486-500. PMID 17446171 DOI: 10.1074/jbc.M700863200  0.96
2007 Isin EM, Guengerich FP. Complex reactions catalyzed by cytochrome P450 enzymes Biochimica Et Biophysica Acta - General Subjects. 1770: 314-329. PMID 17239540 DOI: 10.1016/j.bbagen.2006.07.003  1
2007 Isin EM, Guengerich FP. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 Journal of Biological Chemistry. 282: 6863-6874. PMID 17200113 DOI: 10.1074/jbc.M610346200  1
2007 Guengerich FP. Oxidative, Reductive, and Hydrolytic Metabolism of Drugs Drug Metabolism in Drug Design and Development: Basic Concepts and Practice. 15-35. DOI: 10.1002/9780470191699.ch2  1
2007 Guengerich FP. Drug metabolism as catalyzed by human cytochrome P450 systems Metal Ions in Life Sciences. 3: 561-589.  1
2006 Guengerich FP. A malleable catalyst dominates the metabolism of drugs Proceedings of the National Academy of Sciences of the United States of America. 103: 13565-13566. PMID 16954196 DOI: 10.1073/pnas.0606333103  1
2006 Guengerich FP, Martin MV. Purification of cytochromes P450: products of bacterial recombinant expression systems Methods in Molecular Biology (Clifton, N.J.). 320: 31-37. PMID 16719372  1
2006 Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. The Febs Journal. 273: 2223-31. PMID 16649998 DOI: 10.1111/j.1742-4658.2006.05235.x  1
2006 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity Aaps Journal. 8. PMID 16584116 DOI: 10.1208/aapsj080112  1
2006 Wu ZL, Sohl CD, Shimada T, Guengerich FP. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Molecular Pharmacology. 69: 2007-14. PMID 16551781 DOI: 10.1124/mol.106.023648  1
2006 Isin EM, Guengerich FP. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 Journal of Biological Chemistry. 281: 9127-9136. PMID 16467307 DOI: 10.1074/jbc.M511375200  1
2006 Guengerich FP. Interactions of carcinogen-bound DNA with individual DNA polymerases Chemical Reviews. 106: 420-452. PMID 16464013 DOI: 10.1021/cr0404693  1
2006 Guengerich FP. Safety assessment of stable drug metabolites Chemical Research in Toxicology. 19: 1559-1560. DOI: 10.1021/tx060223o  1
2006 Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction Biochemistry and Molecular Biology Education. 34: 66-74. DOI: 10.1002/bmb.2006.49403402066  1
2005 Guengerich FP. Activation of alkyl halides by glutathione transferases Methods in Enzymology. 401: 342-353. PMID 16399396 DOI: 10.1016/S0076-6879(05)01021-9  1
2005 Guengerich FP. How I became a biochemist Iubmb Life.. 57: 705-707. PMID 16223712  1
2005 Kim D, Wu ZL, Guengerich FP. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. The Journal of Biological Chemistry. 280: 40319-27. PMID 16207711 DOI: 10.1074/jbc.M508171200  0.96
2005 Choi JY, Guengerich FP. Adduct size limits efficient and error-free bypass across bulky N 2-guanine DNA lesions by human DNA polymerase η Journal of Molecular Biology. 352: 72-90. PMID 16061253 DOI: 10.1016/j.jmb.2005.06.079  1
2005 Guengerich FP. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase Archives of Biochemistry and Biophysics. 440: 204-211. PMID 16055078 DOI: 10.1016/j.abb.2005.06.019  1
2005 Zang H, Fang Q, Pegg AE, Guengerich FP. Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. The Journal of Biological Chemistry. 280: 30873-81. PMID 16000301 DOI: 10.1074/jbc.M505283200  0.36
2005 Guengerich FP. Life and times in biochemical toxicology International Journal of Toxicology. 24: 5-21. PMID 15981736 DOI: 10.1080/10915810590918670  1
2005 Guengerich FP. Generation of reactive intermediates Journal of Biochemical and Molecular Toxicology. 19: 173-174. PMID 15977199 DOI: 10.1002/jbt.20072  1
2005 Liebler DC, Guengerich FP. Elucidating mechanisms of drug-induced toxicity Nature Reviews Drug Discovery. 4: 410-420. PMID 15864270 DOI: 10.1038/nrd1720  1
2005 Kim D, Guengerich FP. Cytochrome P450 activation of arylamines and heterocyclic amines. Annual Review of Pharmacology and Toxicology. 45: 27-49. PMID 15822170 DOI: 10.1146/annurev.pharmtox.45.120403.100010  1
2005 VanderVeen LA, Druckova A, Riggins JN, Sorrells JL, Guengerich FP, Marnett LJ. Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct Biochemistry. 44: 5024-5033. PMID 15794640 DOI: 10.1021/bi0472898  1
2005 Krauser JA, Guengerich FP. Cytochrome P450 3A4-catalyzed testosterone 6β-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps Journal of Biological Chemistry. 280: 19496-19506. PMID 15772082 DOI: 10.1074/jbc.M501854200  1
2005 Vélez-Cruz R, Riggins JN, Daniels JS, Cai H, Guengerich FP, Marnett LJ, Osheroff N. Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase IIα in vitro and in cultured cells Biochemistry. 44: 3972-3981. PMID 15751973 DOI: 10.1021/bi0478289  1
2005 Yun CH, Kim KH, Calcutt MW, Guengerich FP. Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. The Journal of Biological Chemistry. 280: 12279-91. PMID 15665333 DOI: 10.1074/jbc.M411019200  1
2005 Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, et al. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. The Journal of Biological Chemistry. 280: 11599-607. PMID 15659395 DOI: 10.1074/jbc.M410933200  1
2005 Guengerich FP. Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation Archives of Biochemistry and Biophysics. 433: 369-378. PMID 15581593 DOI: 10.1016/j.abb.2004.07.035  1
2005 Guengerich FP. 15th International Symposium on microsomes and drug oxidations Archives of Biochemistry and Biophysics. 433: 341. DOI: 10.1016/j.abb.2004.10.013  1
2004 Guengerich FP. Where is toxicology headed in the future? Drug Metabolism Reviews. 36: 475-486. PMID 15554230 DOI: 10.1081/DMR-200033409  1
2004 Kim D, Guengerich FP. Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. Archives of Biochemistry and Biophysics. 432: 102-8. PMID 15519301 DOI: 10.1016/j.abb.2004.09.001  0.96
2004 Guengerich FP. Cytochrome P450: What have we learned and what are the future issues? Drug Metabolism Reviews. 36: 159-197. PMID 15237850 DOI: 10.1081/DMR-120033996  1
2004 Kim D, Kadlubar FF, Teitel CH, Guengerich FP. Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines. Chemical Research in Toxicology. 17: 529-36. PMID 15089095 DOI: 10.1021/tx034267y  0.96
2004 Kim D, Guengerich FP. Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. Biochemistry. 43: 981-8. PMID 14744142 DOI: 10.1021/bi035593f  1
2004 Zhou H, Josephy PD, Kim D, Guengerich FP. Functional characterization of four allelic variants of human cytochrome P450 1A2. Archives of Biochemistry and Biophysics. 422: 23-30. PMID 14725854 DOI: 10.1016/j.abb.2003.11.019  1
2004 Valadez JG, Guengerich FP. S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage Journal of Biological Chemistry. 279: 13435-13446. PMID 14715658 DOI: 10.1074/jbc.M312358200  1
2003 Guengerich FP. Cytochromes P450, drugs, and diseases Mol Interv. 3: 194-204. PMID 14993447  1
2003 Guengerich FP. Activation of dihaloalkanes by thiol-dependent mechanisms Journal of Biochemistry and Molecular Biology. 36: 20-27. PMID 12542971  1
2003 Guengerich FP. Cytochrome P450 oxidations in the generation of reactive electrophiles: Epoxidation and related reactions Archives of Biochemistry and Biophysics. 409: 59-71. PMID 12464245 DOI: 10.1016/S0003-9861(02)00415-0  1
2002 Bell-Parikh LC, Hosea NA, Martin MV, Guengerich FP. Purification of cytochrome P-450 enzymes. Current Protocols in Toxicology. Unit4.2. PMID 23045082 DOI: 10.1002/0471140856.tx0402s12  0.44
2002 Guengerich FP, Wheeler JB, Chun YJ, Kim D, Shimada T, Aryal P, Oda Y, Gillam EM. Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. Toxicology. 181: 261-4. PMID 12505322 DOI: 10.1016/S0300-483X(02)00293-7  1
2002 Kim D, Guengerich FP. Random mutagenesis by whole-plasmid PCR amplification. Methods in Molecular Biology (Clifton, N.J.). 192: 241-5. PMID 12494656 DOI: 10.1385/1-59259-177-9:241  1
2002 Guengerich FP. Rate-limiting steps in cytochorme P450 catalysis Biological Chemistry. 383: 1553-1564. PMID 12452431 DOI: 10.1515/BC.2002.175  1
2002 Guengerich FP. N-hydroxyarylamines Drug Metabolism Reviews. 34: 607-623. PMID 12214670 DOI: 10.1081/DMR-120005663  1
2002 Guengerich FP. Cytochrome P450 enzymes in the generation of commercial products Nature Reviews Drug Discovery. 1: 359-366. PMID 12120411  1
2002 Guengerich FP. Update information on human P450s Drug Metabolism Reviews. 34: 7-15. PMID 11996014 DOI: 10.1081/DMR-120001386  1
2002 Gillam EMJ, Guengerich FP. Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology Iubmb Life. 52: 271-277. PMID 11895075 DOI: 10.1080/152165401317291110  1
2002 Woodside AM, Guengerich FP. Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Biochemistry. 41: 1039-50. PMID 11790128  0.92
2002 Woodside AM, Guengerich FP. Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Biochemistry. 41: 1027-38. PMID 11790127  0.92
2002 Rendic S, Guengerich FP. Special issue on human cytochromes P450 (human CYPs): Human cytochrome P450 enzymes, a status report summarizing their reactions, substrates, inducers and inhibitors - 1st update: Foreword Drug Metabolism Reviews. 34.  1
2001 Chun YJ, Kim S, Kim D, Lee SK, Guengerich FP. A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Research. 61: 8164-70. PMID 11719446  0.96
2001 Miller GP, Hanna IH, Nishimura Y, Guengerich FP. Oxidation of phenethylamine derivatives by cytochrome P450 2D6: The issue of substrate protonation in binding and catalysis Biochemistry. 40: 14215-14223. PMID 11714275 DOI: 10.1021/bi0110037  1
2001 Guengerich FP. Functional genomics and proteomics applied to the study of nutritional metabolism Nutrition Reviews. 59: 259-263. PMID 11518180  1
2001 Guengerich FP. Uncommon P450-catalyzed reactions Current Drug Metabolism. 2: 93-115. PMID 11469727 DOI: 10.2174/1389200013338694  1
2001 Guengerich FP. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Chemical Research in Toxicology. 14: 611-650. PMID 11409933  1
2001 Miller GP, Guengerich FP. Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: Evidence for two binding sites Biochemistry. 40: 7262-7272. PMID 11401574  1
2001 Guengerich FP. Forging the links between metabolism and carcinogenesis Mutation Research - Reviews in Mutation Research. 488: 195-209. PMID 11397649 DOI: 10.1016/S1383-5742(01)00059-X  1
2001 Cai H, Guengerich FP. Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: Inactivation and sites of modification Chemical Research in Toxicology. 14: 451-458. PMID 11304134 DOI: 10.1021/tx0002280  1
2001 Yun CH, Miller GP, Guengerich FP. Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: Structure - Activity relationships and simulation of rate constants of individual steps in catalysis Biochemistry. 40: 4521-4530. PMID 11284709 DOI: 10.1021/bi002906n  1
2000 Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM. What makes P450s work? Searches for answers with known and new P450s. Drug Metabolism Reviews. 32: 267-81. PMID 11139129 DOI: 10.1081/DMR-100102334  0.96
2000 Yun CH, Miller GP, Guengerich FP. Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants Biochemistry. 39: 11319-11329. PMID 10985777 DOI: 10.1021/bi000869u  1
2000 Hosea NA, Miller GP, Guengerich FP. Elucidation of distinct ligand binding sites for cytochrome P450 3A4 Biochemistry. 39: 5929-5939. PMID 10821664 DOI: 10.1021/bi992765t  1
2000 Cai H, Guengerich FP. Acylation of protein lysines by trichloroethylene oxide Chemical Research in Toxicology. 13: 327-335. PMID 10813648 DOI: 10.1021/tx000003p  1
2000 Guengerich FP. Metabolism of chemical carcinogens Carcinogenesis. 21: 345-351. PMID 10688854  1
2000 Sato H, Guengerich FP. Oxidation of 1,2,4,5-tetramethoxybenzene to a cation radical by cytochrome P450 [15] Journal of the American Chemical Society. 122: 8099-8100. DOI: 10.1021/ja000838m  1
2000 Guengerich FP. Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics Drug Development Research. 49: 4-16. DOI: 10.1002/(SICI)1098-2299(200001)49:1<4::AID-DDR2>3.0.CO;2-R  1
1999 Gillam EM, Aguinaldo AM, Notley LM, Kim D, Mundkowski RG, Volkov AA, Arnold FH, Soucek P, DeVoss JJ, Guengerich FP. Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications. 265: 469-72. PMID 10558891 DOI: 10.1006/bbrc.1999.1702  0.96
1999 Akasaka S, Guengerich FP. Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA Chemical Research in Toxicology. 12: 501-507. PMID 10368312 DOI: 10.1021/tx980259j  1
1999 Guengerich FP. Cytochrome P-450 3A4: Regulation and role in drug metabolism Annual Review of Pharmacology and Toxicology. 39: 1-17. PMID 10331074 DOI: 10.1146/annurev.pharmtox.39.1.1  1
1999 Guengerich FP. The Vanderbilt University Center in Molecular Toxicology: the first 30 years Drug Metabolism Reviews. 31: 1-11. PMID 10065362  1
1999 Cai H, Guengerich FP. Mechanism of aqueous decomposition of trichloroethylene oxide Journal of the American Chemical Society. 121: 11656-11663. DOI: 10.1021/ja9914240  1
1998 Guengerich FP, Martin MV. Purification of cytochromes P450. Rat and human hepatic forms Methods in Molecular Biology (Clifton, N.J.). 107: 35-53. PMID 14577211  1
1998 Guengerich FP, Shimada T. Activation of procarcinogens by human cytochrome P450 enzymes Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 400: 201-213. PMID 9685642 DOI: 10.1016/S0027-5107(98)00037-2  1
1998 Guengerich FP. The environmental genome project: Functional analysis of polymorphisms Environmental Health Perspectives. 106: 365-368. PMID 9637792  1
1998 Furge LL, Guengerich FP. Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. Biochemistry. 37: 3567-74. PMID 9521678 DOI: 10.1021/bi9722094  0.56
1998 Hosea NA, Guengerich FP. Oxidation of nonionic detergents by cytochrome P450 enzymes Faseb Journal. 12. DOI: 10.1006/abbi.1998.0659  1
1998 Guengerich FP, Wunsch UM. Expression of human cytochrome P450 1B1 in bacteria Faseb Journal. 12.  1
1998 Guengerich FP, Hosea NA. Cytochrome P450 3A4: Diversity of reactions, cooperativity, and component interactions Proceedings of the Western Pharmacology Society. 41: 267.  1
1998 Parikh A, Guengerich FP. Random mutagenesis via whole plasmid PCR amplification Faseb Journal. 12.  1
1997 Guengerich FP. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species Chemico-Biological Interactions. 106: 161-182. PMID 9413544 DOI: 10.1016/S0009-2797(97)00068-9  1
1997 Guengerich FP. Role of Cytochrome P450 Enzymes in Drug-Drug Interactions Advances in Pharmacology. 43: 7-35. PMID 9342171 DOI: 10.1016/S1054-3589(08)60200-8  1
1997 Furge LL, Guengerich FP. Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Biochemistry. 36: 6475-87. PMID 9174365 DOI: 10.1021/bi9627267  0.52
1997 Anderson KE, Hammons GJ, Kadlubar FF, Potter JD, Kaderlik KR, Ilett KF, Minchin RF, Teitel CH, Chou HC, Martin MV, Guengerich FP, Barone GW, Lang NP, Peterson LA. Metabolic activation of aromatic amines by human pancreas. Carcinogenesis. 18: 1085-92. PMID 9163700 DOI: 10.1093/carcin/18.5.1085  1
1997 Parikh A, Guengerich FP. Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:Rat NADPH-cytochrome P450 reductase fusion protein Protein Expression and Purification. 9: 346-354. PMID 9126606 DOI: 10.1006/prep.1997.0721  1
1997 Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis. 18: 851-4. PMID 9111224 DOI: 10.1093/carcin/18.4.851  1
1997 Chun YJ, Jeong TC, Roh JK, Guengerich FP. Characterization of a fusion protein between human cytochrome P450 1A1 and rat NADPH-P450 oxidoreductase in Escherichia coli. Biochemical and Biophysical Research Communications. 230: 211-4. PMID 9020048 DOI: 10.1006/bbrc.1996.5918  0.32
1997 Guengerich FP, Vaz AD, Raner GN, Pernecky SJ, Coon MJ. Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. Molecular Pharmacology. 51: 147-51. PMID 9016357  1
1997 Guengerich FP. Mechanisms of mutagenicity of DNA adducts derived from alkyl and vinyl halides Japanese Journal of Toxicology and Environmental Health. 43: 69-82.  1
1996 Guengerich FP. In vitro techniques for studying drug metabolism Journal of Pharmacokinetics and Biopharmaceutics. 24: 521-533. PMID 9131489 DOI: 10.1007/BF02353478  1
1996 Lowe LG, Guengerich FP. Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-+ Biochemistry. 35: 9840-9849. PMID 8703958 DOI: 10.1021/bi960485x  1
1995 Guengerich FP. Cytochrome P450 proteins and potential utilization in biodegradation Environmental Health Perspectives. 103: 25-28. PMID 8565903  1
1995 Guengerich FP. Influence of nutrients and other dietary materials on cytochrome P-450 enzymes American Journal of Clinical Nutrition. 61. PMID 7879733  1
1994 Guengerich FP, Persmark M. Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde Chemical Research in Toxicology. 7: 205-208. PMID 8199310  1
1994 Guengerich FP. Mechanisms of formation of DNA adducts from ethylene dihaudes, vinyl halides, and arylamines Drug Metabolism Reviews. 26: 47-66. PMID 8082581 DOI: 10.3109/03602539409029784  1
1994 Guengerich FP. Metabolism and genotoxicity of dihaloalkanes Advances in Pharmacology (San Diego, Calif.). 27: 211-236. PMID 8068554  1
1994 Persmark M, Guengerich FP. Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG * CAAG) with potential complements Biochemistry. 33: 8662-8672. PMID 8038155  1
1993 Seto Y, Guengerich FP. Partitioning between N-dealkylation and N-oxygenation in the oxidation of N,N-dialkylarylamines catalyzed by cytochrome P450 2B1 Journal of Biological Chemistry. 268: 9986-9997. PMID 8486725  1
1993 Okazaki O, Guengerich FP. Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase: Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases Journal of Biological Chemistry. 268: 1546-1552. PMID 8380572  1
1993 Seto Y, Guengerich FP. Liquid chromatographic determination of para-substituted N,N-dialkylaniline N-oxides Journal of Chromatography B: Biomedical Sciences and Applications. 619: 71-77. PMID 8245165 DOI: 10.1016/0378-4347(93)80447-C  1
1993 Kim MS, Guengerich FP. Interactions of N7-guanyl methyl- and thioether-substituted d(CATGCCT) derivatives with d(AGGNATG) Chemical Research in Toxicology. 6: 900-905. PMID 8117931  1
1993 Guengerich FP. The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals Drug Metabolism and Disposition. 21: 1-6. PMID 8095200  1
1993 Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Dna and Cell Biology. 12: 1-51. PMID 7678494 DOI: 10.1089/dna.1993.12.1  1
1992 Raney KD, Shimada T, Kim DH, Groopman JD, Harris TM, Guengerich FP. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chemical Research in Toxicology. 5: 202-10. PMID 1643250 DOI: 10.1021/tx00026a009  1
1992 Guengerich FP, Raney KD, Kim DH, Shimada T, Meyer DJ, Ketterer B, Harris TM. Oxidation and conjugation of aflatoxins by humans and experimental animals. Progress in Clinical and Biological Research. 374: 157-65. PMID 1620701  1
1992 Guengerich FP. Roles of the vinyl chloride oxidation products 2-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases Chemical Research in Toxicology. 5: 2-5. PMID 1581532  1
1992 Guengerich FP. Characterization of human cytochrome P450 enzymes Faseb Journal. 6: 745-748. PMID 1537465  1
1992 Guengerich FP. Cytochrome P450: Advances and prospects Faseb Journal. 6: 667-668. PMID 1537453  1
1992 Kadlubar FF, Guengerich FP. Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens Chemosphere. 25: 201-204. DOI: 10.1016/0045-6535(92)90513-Q  1
1992 Guengerich FP, Raney VM. Formation of etheno adducts of adenosine and cytidine from 1-halooxiranes. Evidence for a mechanism involving initial reaction with the endocyclic nitrogen atoms Journal of the American Chemical Society. 114: 1074-1080.  1
1991 Miranda CL, Reed RL, Guengerich FP, Buhler DR. Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver Carcinogenesis. 12: 515-519. PMID 2009596 DOI: 10.1093/carcin/12.3.515  1
1991 Guengerich FP, Turvy CG. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples Journal of Pharmacology and Experimental Therapeutics. 256: 1189-1194. PMID 2005581  1
1991 Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF. The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. Dna and Cell Biology. 10: 1-14. PMID 1991046 DOI: 10.1089/dna.1991.10.1  1
1991 Guengerich FP. Molecular advances for the cytochrome P-450 superfamily Trends in Pharmacological Sciences. 12: 281-283. PMID 1949194 DOI: 10.1016/0165-6147(91)90574-C  1
1991 Humphreys WG, Kim DH, Guengerich FP. Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane. Chemical Research in Toxicology. 4: 445-53. PMID 1912332  1
1991 Guengerich FP, Kim DH. Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine. Chemical Research in Toxicology. 4: 413-21. PMID 1912327  1
1991 Guengerich FP, Shimada T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes Chemical Research in Toxicology. 4: 391-407. PMID 1912325  1
1991 Humphreys WG, Guengerich FP. Structure of formamidopyrimidine adducts as determined by NMR using specifically 15N-labeled guanosine Chemical Research in Toxicology. 4: 632-636. PMID 1807445  1
1991 Guengerich FP, Kim DH, Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chemical Research in Toxicology. 4: 168-79. PMID 1664256  1
1990 Kim DH, Guengerich FP. Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis. 11: 419-24. PMID 2311185 DOI: 10.1093/carcin/11.3.419  1
1990 Guengerich FP, Kim DH. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis. 11: 2275-9. PMID 2265479  1
1990 Humphreys WG, Kim DH, Cmarik JL, Shimada T, Guengerich FP. Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives. Biochemistry. 29: 10342-50. PMID 2261477  1
1990 Guengerich FP. Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs American Journal of Obstetrics and Gynecology. 163: 2159-2163. PMID 2256525 DOI: 10.1016/0002-9378(90)90557-N  1
1990 Guengerich FP, MacDonald TL. Mechanisms of cytochrome P-450 catalysis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 2453-9. PMID 2185971  1
1990 Shimada T, Guengerich FP. Inactivation of l,3-, l,6-, and 1,8-Dinitropyrene by Cytochrome P-450 Enzymes in Human and Rat Liver Microsomes Cancer Research. 50: 2036-2043. PMID 2180560  1
1990 Guengerich FP, Humphreys WG, Kim DH, Oida T, Cmarik JL. DNA-glutathione adducts derived from vic-dihaloalkanes: mechanisms of mutagenesis. Princess Takamatsu Symposia. 21: 101-7. PMID 2134669  1
1990 Guengerich FP. Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene Chemical Research in Toxicology. 3: 363-371. PMID 2133086  1
1990 Guengerich FP. Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism Chemical Research in Toxicology. 3: 21-26. PMID 2131820  1
1990 Kim DH, Humphreys WG, Guengerich FP. Characterization of S-[2-(N1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane. Chemical Research in Toxicology. 3: 587-94. PMID 1715767  1
1990 Guengerich FP. Chemical mechanisms of cytochrome P-450 catalysis Asia Pacific Journal of Pharmacology. 5: 253-268.  1
1990 Guengerich FP. Characterization of roles of human cytochrome P-450 enzymes in carcinogen metabolism Asia Pacific Journal of Pharmacology. 5: 327-345.  1
1989 Guengerich FP. Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins Journal of Biological Chemistry. 264: 17198-17205. PMID 2793846  1
1989 Kim DH, Guengerich FP. Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats. Cancer Research. 49: 5843-7. PMID 2790795  1
1989 Guengerich FP. Characterization of human microsomal cytochrome P-450 enzymes Annual Review of Pharmacology and Toxicology. 29: 241-264. PMID 2658771  1
1989 Nebert DW, Nelson DR, Adesnik M, Coon MJ, Estabrook RW, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF, Kemper B. The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. Dna (Mary Ann Liebert, Inc.). 8: 1-13. PMID 2651058  1
1989 Macdonald TL, Gutheim WG, Martin RB, Guengerich FP. Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450. Biochemistry. 28: 2071-7. PMID 2497774 DOI: 10.1021/bi00431a016  1
1989 Shimada T, Guengerich FP. Evidence for cytochrome P-450(NF), the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver Proceedings of the National Academy of Sciences of the United States of America. 86: 462-465. PMID 2492107  1
1988 Guengerich FP, Bocker RH. Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines Journal of Biological Chemistry. 263: 8168-8175. PMID 3372517  1
1988 Beaune PH, Guengerich FP. Human drug metabolism in vitro Pharmacology and Therapeutics. 37: 193-211. PMID 3290907 DOI: 10.1016/0163-7258(88)90025-3  1
1988 Guengerich FP. Oxidation of 17α-ethynylestradiol by human liver cytochrome P-450 Molecular Pharmacology. 33: 500-508. PMID 3285175  1
1988 Gozakara EM, Guengerich FP, Gelboin HV. Cell-catalyzed binding of 3h-(-)-trans-7, 8-dihydroxy-7, 8 dihydrobenzo[a]pyrene to cellular and exogenous dna and the role of purified human liver epoxide hydrolase Pharmacology. 37: 154-164. PMID 3227049 DOI: 10.1159/000138459  1
1988 Guengerich FP. Cytochromes P-450 Comparative Biochemistry and Physiology. Part C, Comparative. 89: 1-4. PMID 2894265 DOI: 10.1016/0742-8413(88)90137-5  1
1987 Nebert DW, Adesnik M, Coon MJ, Estabrook RW, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF, Kemper B, Levin W. The P450 gene superfamily: recommended nomenclature. Dna (Mary Ann Liebert, Inc.). 6: 1-11. PMID 3829886  1
1987 Wolff T, Guengerich FP. Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes Biochemical Pharmacology. 36: 2581-2588. PMID 3606656 DOI: 10.1016/0006-2952(87)90535-1  1
1987 Guengerich FP. Oxidative cleavage of carboxylic esters by cytochrome P-450 Journal of Biological Chemistry. 262: 8459-8462. PMID 3597381  1
1987 Guengerich FP, Peterson LA, Cmarik JL, Koga N, Inskeep PB. Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts. Environmental Health Perspectives. 76: 15-8. PMID 3329096 DOI: 10.1289/ehp.877615  1
1987 Guengerich FP. Multiple forms of cytochrome P-450 Isi Atlas of Science: Pharmacology. 1: 205-207.  1
1986 Tephly TR, Black KA, Green MD, Coffman BL, Dannan GA, Guengerich FP. Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins. Advances in Experimental Medicine and Biology. 197: 243-51. PMID 3766261 DOI: 10.1007/978-1-4684-5134-4_21  1
1986 Böcker RH, Guengerich FP. Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450 Journal of Medicinal Chemistry. 29: 1596-1603. PMID 3746811  1
1986 Guengerich FP. Roles of Cytochrome P-450 Enzymes in Chemical Carcinogenesis and Cancer Chemotherapy Cancer Research. 48: 2946-2954. PMID 3284639  1
1986 Guengerich FP. Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed Biochemical and Biophysical Research Communications. 138: 193-198. PMID 2874799 DOI: 10.1016/0006-291X(86)90265-2  1
1986 Hogy LL, Guengerich FP. In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with dna in rats1 Cancer Research. 46: 3932-3938. PMID 2425936  1
1985 Shimada T, Guengerich FP. Participation of a rat liver cytochrome P-450 induced by pregnenolone 16α-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin Molecular Pharmacology. 28: 215-219. PMID 4022003  1
1985 Guengerich FP, Liebler DC, Reed DL. Enzymatic activation of chemicals to toxic metabolites Critical Reviews in Toxicology. 14: 259-307. PMID 3926381 DOI: 10.3109/10408448509037460  1
1985 Kaminsky LS, Guengerich FP. Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin European Journal of Biochemistry. 149: 479-489. PMID 3924614  1
1985 Inskeep PB, Guengerich FP. Glutathione-mediated binding of ethylene dibromide to DNA in rat and human hepatocytes and half-life of the DNA adduct in rat liver Federation Proceedings. 44.  1
1984 Distlerath LM, Guengerich FP. Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme Proceedings of the National Academy of Sciences of the United States of America. 81: 7348-7352. PMID 6594694  1
1984 Guengerich FP. Oxidation of sparteines by cytochrome P-450: Evidence against the formation of N-oxides [2] Journal of Medicinal Chemistry. 27: 1101-1103. PMID 6471064  1
1984 Shiraki H, Guengerich FP. Turnover of membrane proteins: Kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase Archives of Biochemistry and Biophysics. 235: 86-96. PMID 6437340 DOI: 10.1016/0003-9861(84)90257-1  1
1984 Guengerich FP. Factors involved in the regulation of the levels and activities of rat liver cytochromes P-450 Biochemical Society Transactions. 12: 68-70. PMID 6423422  1
1984 Guengerich FP. Effects of nutritive factors on metabolic processes involving bioactivation and detoxication of chemicals Annual Review of Nutrition. 4: 207-231. PMID 6380537  1
1984 Inskeep PB, Guengerich FP. Glutathione-mediated binding of dibromoalkanes to dna: Specificity of rat glutathione-s-transferases and dibromoalkane structure Carcinogenesis. 5: 805-808. PMID 6373044 DOI: 10.1093/carcin/5.6.805  1
1984 Inskeep PB, Guengerich FP. Glutathione-mediated binding of dibromoalkanes to DNA and biological half-life of dibromoethane-DNA adducts Federation Proceedings. 43.  1
1984 Distlerath LM, Guengerich FP. Purification of a rat liver microsomal cytochrome P-450 responsible for debrisoquine 4-hydroxylation Federation Proceedings. 43.  1
1984 Guengerich FP, Macdonald TL. Chemical mechanisms of catalysis by cytochromes P-450: A unified view Accounts of Chemical Research. 17: 9-16.  1
1984 Kaminsky LS, Guengerich FP. Cytochrome P-450 (P-450) isozyme:isozyme and P-450:NADPH-P-450 reductase functional interactions in reconstituted systems and microsomal membranes Federation Proceedings. 43.  1
1984 Schaefer WH, Guengerich FP. Products of cytochrome P-450 heme formed under peroxidative conditions Federation Proceedings. 43.  1
1983 Wilkinson CF, Hetnarski K, Denison MS, Guengerich FP. Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation. Biochemical Pharmacology. 32: 997-1003. PMID 6838663 DOI: 10.1016/0006-2952(83)90617-2  1
1983 Miller RE, Guengerich FP. Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome p-450 Cancer Research. 43: 1145-1152. PMID 6825087  1
1983 Liebler DC, Guengerich FP. Olefin oxidation by cytochrome P-450: Evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene Biochemistry. 22: 5482-5489. PMID 6652073  1
1983 Ozawa N, Guengerich FP. Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA Proceedings of the National Academy of Sciences of the United States of America. 80: 5266-5270. PMID 6577422  1
1983 Guengerich FP. Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome P-450 reductase related to catalysis in reconstituted systems Biochemistry. 22: 2811-2820. PMID 6307349  1
1982 Miller RE, Guengerich FP. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide Biochemistry. 21: 1090-1097. PMID 7074051  1
1982 Meijer J, Astrom A, DePierre JW, Guengerich FP, Ernster L. Characterization of the microsomal cytochrome P-450 species induced in rat liver by trans-stilbene oxide. Biochemical Pharmacology. 31: 3907-16. PMID 6984333 DOI: 10.1016/0006-2952(82)90309-4  1
1982 Dannan GA, Guengerich FP. Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues Molecular Pharmacology. 22: 787-794. PMID 6818451  1
1982 Guengerich FP, Davidson NK. Interaction of epoxide hydrolase with itself and other microsomal proteins Archives of Biochemistry and Biophysics. 215: 462-477. PMID 6807211 DOI: 10.1016/0003-9861(82)90105-9  1
1982 Macdonald TL, Burka LT, Wright ST, Guengerich FP. Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water. Biochemical and Biophysical Research Communications. 104: 620-5. PMID 6803786 DOI: 10.1016/0006-291X(82)90682-9  1
1981 Gozukara EM, Belvedere G, Robinson RC, Deutsch J, Coon MJ, Guengerich FP, Gelboin HV. The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins Molecular Pharmacology. 19: 153-161. PMID 7193798  1
1981 Guengerich FP. Metabolism of vinyl halides: in vitro studies on roles of potential activated metabolites Advances in Experimental Medicine and Biology. 136: 685-692. PMID 7046381  1
1981 Ohlsson RI, Lane CD, Guengerich FP. Synthesis and insertion, both in vivo and in vitro, of rat-liver cytochrome P-450 and epoxide hydratase into Xenopus laevis membranes. European Journal of Biochemistry / Febs. 115: 367-73. PMID 6165584 DOI: 10.1111/j.1432-1033.1981.tb05247.x  1
1981 Kaminsky LS, Guengerich FP. Metabolism of polychlorinated biphenyls by highly purified rat liver cytochromes P-450 Federation Proceedings. 40: 23.  1
1980 Guengerich FP, Mason PS. Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity Analytical Biochemistry. 104: 445-451. PMID 7004265 DOI: 10.1016/0003-2697(80)90097-4  1
1980 Guengerich FP, Martin MV. Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes Archives of Biochemistry and Biophysics. 205: 365-379. PMID 6781411 DOI: 10.1016/0003-9861(80)90119-8  1
1980 French JS, Guengerich FP, Coon MJ. Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system Journal of Biological Chemistry. 255: 4112-4119. PMID 6768748  1
1980 Guengerich FP, Mitchell MB. Metabolic activation of model pyrroles by cytochrome P-450 Drug Metabolism and Disposition. 8: 34-38. PMID 6102027  1
1979 Guengerich FP. Similarity of nuclear and microsomal cytochromes P-450 in the in vitro activation of aflatoxin B1 Biochemical Pharmacology. 28: 2883-2890. PMID 518685 DOI: 10.1016/0006-2952(79)90583-5  1
1979 Guengerich FP, Watanabe PG. Metabolism of [14C]- and [36Cl]-labeled vinyl chloride in vivo and in vitro Biochemical Pharmacology. 28: 589-596. PMID 444246 DOI: 10.1016/0006-2952(79)90140-0  1
1979 Guengerich FP. Isolation and purification of cytochrome P-450, and the existence of multiple forms Pharmacology and Therapeutics. 6: 99-121. PMID 390562 DOI: 10.1016/0163-7258(79)90057-3  1
1979 Guengerich FP. Artifacts in isoelectric focusing of the microsomal enzymes cytochrome P-450 and NADPH-cytochrome P-450 reductase Bba - Protein Structure. 577: 132-141. PMID 106898 DOI: 10.1016/0005-2795(79)90015-1  1
1979 Guengerich FP, Mason PS. Immunological comparison of hepatic and extrahepatic cytochromes P-450 Molecular Pharmacology. 15: 154-164. PMID 106233  1
1979 Mitchell MB, Guengerich FP. Activation of alkyl pyrroles by cytochromes P-450 Federation Proceedings. 38.  1
1978 Guengerich FP. Comparison of highly-purified microsomal cytochromes P-450 and NADPH-cytochrome P-450 reductases by peptide mapping Biochemical and Biophysical Research Communications. 82: 820-827. PMID 697774 DOI: 10.1016/0006-291X(78)90856-2  1
1978 Guengerich FP. Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats Journal of Biological Chemistry. 253: 7931-7939. PMID 100498  1
1978 Guengerich FP. Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase Biochemistry. 17: 3633-3639. PMID 28754  1
1978 Guengerich FP. Nuclear and microsomal cytochromes P-450: Similarity and activities towards aflatoxin B1 Pharmacologist. 20: 128.  1
1977 Guengerich FP. Studies on the activation of a model furan compound-toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan Biochemical Pharmacology. 26: 1909-1915. PMID 911344 DOI: 10.1016/0006-2952(77)90165-4  1
1977 Guengerich FP, Strickland TW. Metabolism of vinyl chloride: destruction of the heme of highly purified liver Microsomal cytochrome P-450 by a metabolite. Molecular Pharmacology. 13: 993-1004. PMID 413029  1
1977 Guengerich FP. Preparation and properties of highly purified cytochrome P-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits Molecular Pharmacology. 13: 911-923. PMID 408601  1
1977 Guengerich FP. Separation and purification of multiple forms of microsomal cytochrome P 450. Activities of different forms of cytochrome P 450 towards several compounds of environmental interest Journal of Biological Chemistry. 252: 3970-3979. PMID 405388  1
1977 Guengerich FP, Aust SD. Activation of the parasympathomimetic alkaloid slaframine by microsomal and photochemical oxidation Molecular Pharmacology. 13: 185-195. PMID 16205  1
1977 Guengerich FP. Activation of the model compound 3 (N ethylcarbamoylhydroxy methyl) furan by cytochromes P 450 Pharmacologist. 19.  1
1976 Coon MJ, Ballou DP, Guengerich FP, Nordblom GD, White RE. Highly purified cytochrome P-450 from liver microsomal membranes: recent studies on the mechanism of catalysis Advances in Experimental Medicine and Biology. 74: 270-280. PMID 961532  1
1976 Peter Guengerich F, Ballou DP, Coon MJ. Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450 Biochemical and Biophysical Research Communications. 70: 951-956. PMID 938535 DOI: 10.1016/0006-291X(76)90684-7  0.84
1976 Guengerich FP, Broquist HP. Lysine catabolism in Rhizoctonia leguminicola and related fungi Journal of Bacteriology. 126: 338-347. PMID 131119  1
1975 Guengerich FP, Ballou DP, Coon MJ. Purified liver microsomal cytochrome P 450. Electron accepting properties and oxidation reduction potential Journal of Biological Chemistry. 250: 7405-7414. PMID 1165247  1
1975 Coon MJ, van der Hoeven A, Haugen DA, Guengerich FP, Vermilion JL, Ballou DP. Biochemical characterization of highly purified cytochrome P-450 and other components of the mixed function oxidase system of liver microsomal membranes. Advances in Experimental Medicine and Biology. 58: 25-46. PMID 168750  1
1975 Guengerich FP, Coon MJ. Rates of individual steps in hydroxylation reactions catalyzed by reconstituted liver microsomal system containing cytochrome P 450 Pharmacologist. 17.  1
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