Peter J. Detloff - Publications

1993- Biochemistry and Molecular Genetics University of Alabama, Birmingham, Birmingham, AL, United States 
Genetics, Biochemistry

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ. Allelic Series of Huntington's Disease Knock-in Mice Reveals Expression Discorrelates. Human Molecular Genetics. PMID 26908599 DOI: 10.1093/Hmg/Ddw040  1
2015 Jin J, Peng Q, Hou Z, Jiang M, Wang X, Langseth AJ, Tao M, Barker PB, Mori S, Bergles DE, Ross CA, Detloff PJ, Zhang J, Duan W. Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease. Human Molecular Genetics. 24: 2508-27. PMID 25609071 DOI: 10.1093/Hmg/Ddv016  1
2015 Ciamei A, Detloff PJ, Morton AJ. Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease Behavioural Brain Research. 291: 140-146. DOI: 10.1016/j.bbr.2015.05.010  1
2013 Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 110: 2366-70. PMID 23341618 DOI: 10.1073/Pnas.1221891110  1
2013 Dougherty SE, Reeves JL, Lesort M, Detloff PJ, Cowell RM. Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington disease. Experimental Neurology. 240: 96-102. PMID 23195593 DOI: 10.1016/J.Expneurol.2012.11.015  1
2012 Kumar A, Kneynsberg A, Tucholski J, Perry G, van Groen T, Detloff PJ, Lesort M. Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease. Experimental Neurology. 237: 78-89. PMID 22698685 DOI: 10.1016/J.Expneurol.2012.05.015  1
2010 Heng MY, Detloff PJ, Paulson HL, Albin RL. Early alterations of autophagy in Huntington disease-like mice. Autophagy. 6: 1206-8. PMID 20935460 DOI: 10.4161/Auto.6.8.13617  1
2010 Heng MY, Duong DK, Albin RL, Tallaksen-Greene SJ, Hunter JM, Lesort MJ, Osmand A, Paulson HL, Detloff PJ. Early autophagic response in a novel knock-in model of Huntington disease. Human Molecular Genetics. 19: 3702-20. PMID 20616151 DOI: 10.1093/Hmg/Ddq285  1
2010 Perry GM, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff PJ, Albin RL, Lesort M. Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease. Human Molecular Genetics. 19: 3354-71. PMID 20558522 DOI: 10.1093/Hmg/Ddq247  1
2009 Heng MY, Detloff PJ, Wang PL, Tsien JZ, Albin RL. In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3200-5. PMID 19279257 DOI: 10.1523/Jneurosci.5599-08.2009  1
2008 Heng MY, Detloff PJ, Albin RL. Rodent genetic models of Huntington disease. Neurobiology of Disease. 32: 1-9. PMID 18638556 DOI: 10.1016/J.Nbd.2008.06.005  1
2008 Gonitel R, Moffitt H, Sathasivam K, Woodman B, Detloff PJ, Faull RL, Bates GP. DNA instability in postmitotic neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 3467-72. PMID 18299573 DOI: 10.1073/Pnas.0800048105  1
2007 Heng MY, Tallaksen-Greene SJ, Detloff PJ, Albin RL. Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8989-98. PMID 17715336 DOI: 10.1523/Jneurosci.1830-07.2007  1
2007 Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK. Intraflagellar transport is essential for endochondral bone formation. Development (Cambridge, England). 134: 307-16. PMID 17166921 DOI: 10.1242/Dev.02732  1
2006 Kim YJ, Sapp E, Cuiffo BG, Sobin L, Yoder J, Kegel KB, Qin ZH, Detloff P, Aronin N, DiFiglia M. Lysosomal proteases are involved in generation of N-terminal huntingtin fragments. Neurobiology of Disease. 22: 346-56. PMID 16423528 DOI: 10.1016/J.Nbd.2005.11.012  1
2005 Crouse AB, Detloff PJ. Allele-specific conditional destabilization of glutamine repeat mRNAs. Gene Expression. 12: 213-22. PMID 16128004 DOI: 10.3727/000000005783992089  1
2005 Hunter JM, Crouse AB, Lesort M, Johnson GV, Detloff PJ. Verification of somatic CAG repeat expansion by pre-PCR fractionation. Journal of Neuroscience Methods. 144: 11-7. PMID 15848234 DOI: 10.1016/J.Jneumeth.2004.10.006  1
2005 Tallaksen-Greene SJ, Crouse AB, Hunter JM, Detloff PJ, Albin RL. Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice. Neuroscience. 131: 843-52. PMID 15749339 DOI: 10.1016/J.Neuroscience.2004.10.037  1
2004 Dixon KT, Cearley JA, Hunter JM, Detloff PJ. Mouse Huntington's disease homolog mRNA levels: variation and allele effects. Gene Expression. 11: 221-31. PMID 15200234 DOI: 10.3727/000000003783992234  1
2004 Choo YS, Johnson GV, MacDonald M, Detloff PJ, Lesort M. Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. Human Molecular Genetics. 13: 1407-20. PMID 15163634 DOI: 10.1093/Hmg/Ddh162  1
2004 Lorincz MT, Detloff PJ, Albin RL, O'Shea KS. Embryonic stem cells expressing expanded CAG repeats undergo aberrant neuronal differentiation and have persistent Oct-4 and REST/NRSF expression. Molecular and Cellular Neurosciences. 26: 135-43. PMID 15121185 DOI: 10.1016/j.mcn.2004.01.016  1
2003 Kennedy L, Evans E, Chen CM, Craven L, Detloff PJ, Ennis M, Shelbourne PF. Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis. Human Molecular Genetics. 12: 3359-67. PMID 14570710 DOI: 10.1093/hmg/ddg352  1
2003 Tallaksen-Greene SJ, Ordway JM, Crouse AB, Jackson WS, Detloff PJ, Albin RL. Hprt(CAG)146 mice: age of onset of behavioral abnormalities, time course of neuronal intranuclear inclusion accumulation, neurotransmitter marker alterations, mitochondrial function markers, and susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The Journal of Comparative Neurology. 465: 205-19. PMID 12949782 DOI: 10.1002/Cne.10855  1
2003 Jackson WS, Tallaksen-Greene SJ, Albin RL, Detloff PJ. Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Human Molecular Genetics. 12: 1621-9. PMID 12812988 DOI: 10.1093/Hmg/Ddg163  1
2001 Cearley JA, Detloff PJ. Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy. Transgenic Research. 10: 479-88. PMID 11817536 DOI: 10.1023/A:1013015616732  1
2001 Lin CH, Tallaksen-Greene S, Chien WM, Cearley JA, Jackson WS, Crouse AB, Ren S, Li XJ, Albin RL, Detloff PJ. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Human Molecular Genetics. 10: 137-44. PMID 11152661 DOI: 10.1093/Hmg/10.2.137  1
2000 King PH, Fuller JJ, Nabors LB, Detloff PJ. Analysis of the 5' end of the mouse Elavl1 (mHuA) gene reveals a transcriptional regulatory element and evidence for conserved genomic organization Gene. 242: 125-131. PMID 10721704 DOI: 10.1016/S0378-1119(99)00537-5  1
1999 Ordway JM, Cearley JA, Detloff PJ. CAG-polyglutamine-repeat mutations: independence from gene context. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1083-8. PMID 10434310 DOI: 10.1098/Rstb.1999.0463  1
1997 Ordway JM, Tallaksen-Greene S, Gutekunst CA, Bernstein EM, Cearley JA, Wiener HW, Dure LS, Lindsey R, Hersch SM, Jope RS, Albin RL, Detloff PJ. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell. 91: 753-63. PMID 9413985 DOI: 10.1016/S0092-8674(00)80464-X  1
1996 Ordway JM, Detloff PJ. In vitro synthesis and cloning of long CAG repeats Biotechniques. 21: 609-612. PMID 8891208 DOI: 10.2144/96214Bm08  1
1996 Lewis J, Yang B, Detloff P, Smithies O. Gene modification via "plug and socket" gene targeting. The Journal of Clinical Investigation. 97: 3-5. PMID 8550847 DOI: 10.1172/Jci118403  1
1995 Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for beta 0-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 92: 11608-12. PMID 8524813 DOI: 10.1073/Pnas.92.25.11608  1
1994 Detloff PJ, Lewis J, John SW, Shehee WR, Langenbach R, Maeda N, Smithies O. Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Molecular and Cellular Biology. 14: 6936-43. PMID 7935410 DOI: 10.1128/Mcb.14.10.6936  1
1992 White MA, Detloff P, Strand M, Petes TD. A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast Current Genetics. 21: 109-116. PMID 1568254 DOI: 10.1007/Bf00318468  1
1992 Detloff P, Petes TD. Measurements of excision repair tracts formed during meiotic recombination in Saccharomyces cerevisiae Molecular and Cellular Biology. 12: 1805-1814. PMID 1549127 DOI: 10.1128/Mcb.12.4.1805  1
1992 Detloff P, White MA, Petes TD. Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae Genetics. 132: 113-123. PMID 1398048  1
1991 Detloff P, Sieber J, Petes TD. Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae Molecular and Cellular Biology. 11: 737-745. PMID 1990280 DOI: 10.1128/Mcb.11.2.737  1
1991 White MA, Wierdl M, Detloff P, Petes TD. DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast Proceedings of the National Academy of Sciences of the United States of America. 88: 9755-9759. PMID 1946399 DOI: 10.1073/Pnas.88.21.9755  1
1989 Petes TD, Detloff P, Jinks-Robertson S, Judd SR, Kupiec M, Nag D, Stapleton A, Symington LS, Vincent A, White M. Recombination in yeast and the recombinant DNA technology. Genome / National Research Council Canada = GéNome / Conseil National De Recherches Canada. 31: 536-40. PMID 2698829 DOI: 10.1139/G89-102  1
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