Tracy M. Handel - Publications

Affiliations: 
1994-2005 Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
 2005- Pharmacology University of California, San Diego, La Jolla, CA 
Area:
General Biophysics, Biochemistry
Website:
https://pharmacy.ucsd.edu/faculty/bios/handel.shtml

151 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dawson JRD, Wadman GM, Zhang P, Gu S, Shroka T, Borrega-Roman L, Salanga CC, Handel TM, Kufareva I. Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5. Biorxiv : the Preprint Server For Biology. PMID 38014122 DOI: 10.1101/2023.11.15.567150  0.329
2023 Schafer CT, Pauszek RF, Gustavsson M, Handel TM, Millar DP. Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes. Biorxiv : the Preprint Server For Biology. PMID 37961571 DOI: 10.1101/2023.10.31.564925  0.328
2023 Gu S, Maurya S, Lona A, Borrega-Roman L, Salanga C, Gonzalez DJ, Kufareva I, Handel TM. Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics. Biorxiv : the Preprint Server For Biology. PMID 37961097 DOI: 10.1101/2023.11.01.565224  0.316
2023 Gu S, Huang M, Handel TM. On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies. Star Protocols. 4: 102460. PMID 37516969 DOI: 10.1016/j.xpro.2023.102460  0.308
2023 Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding. Biorxiv : the Preprint Server For Biology. PMID 37502840 DOI: 10.1101/2023.07.18.549504  0.383
2023 Shroka TM, Kufareva I, Salanga CL, Handel TM. The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms. Science Signaling. 16: eabo4314. PMID 36719944 DOI: 10.1126/scisignal.abo4314  0.323
2022 Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM. Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Science Advances. 8: eabn8063. PMID 35857509 DOI: 10.1126/sciadv.abn8063  0.377
2021 Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. Journal of Medicinal Chemistry. PMID 33600174 DOI: 10.1021/acs.jmedchem.0c01137  0.345
2020 Ward RJ, Pediani JD, Marsango S, Jolly R, Stoneman MR, Biener G, Handel TM, Raicu V, Milligan G. Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. The Journal of Biological Chemistry. 296: 100139. PMID 33460936 DOI: 10.1074/jbc.RA120.016612  0.364
2020 Ward RJ, Pediani JD, Marsango S, Jolly R, Stoneman MR, Biener G, Handel TM, Raicu V, Milligan G. Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. The Journal of Biological Chemistry. PMID 33268380 DOI: 10.1074/jbc.RA120.016612  0.364
2020 Stephens BS, Ngo T, Kufareva I, Handel TM. Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis. Science Signaling. 13. PMID 32665413 DOI: 10.1126/Scisignal.Aay5024  0.478
2020 Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A. Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors. Journal of Leukocyte Biology. PMID 32374043 DOI: 10.1002/Jlb.2Ma0320-383Rr  0.435
2020 Ngo T, Stephens BS, Gustavsson M, Holden LG, Abagyan R, Handel TM, Kufareva I. Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity. Plos Biology. 18: e3000656. PMID 32271748 DOI: 10.1371/Journal.Pbio.3000656  0.436
2019 Zhao BN, Campbell JJ, Salanga CL, Ertl LS, Wang Y, Yau S, Dang T, Zeng Y, McMahon JP, Krasinski A, Zhang P, Kufareva I, Handel TM, Charo IF, Singh R, et al. CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood. Journal of Immunology (Baltimore, Md. : 1950). PMID 31676674 DOI: 10.4049/Jimmunol.1900961  0.405
2019 Gustavsson M, Dyer DP, Zhao C, Handel TM. Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding. Science Signaling. 12. PMID 31506383 DOI: 10.1126/Scisignal.Aaw3657  0.485
2019 Graham GJ, Handel TM, Proudfoot AEI. Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans. Trends in Immunology. PMID 31006548 DOI: 10.1016/J.It.2019.03.009  0.41
2019 Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF. Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on C-methyl methionine labeling of the atypical chemokine receptor ACKR3. Methods in Cell Biology. 149: 259-288. PMID 30616824 DOI: 10.1016/Bs.Mcb.2018.09.004  0.41
2018 Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, et al. CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry. Biochemical Pharmacology. PMID 30342024 DOI: 10.1016/J.Bcp.2018.10.015  0.336
2018 Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Reports. 24: 3312-3323.e5. PMID 30232011 DOI: 10.1016/J.Celrep.2018.08.061  0.354
2018 Proudfoot AE, Handel TM, Graham G. Editorial: Chemokines - beyond chemotaxis. Cytokine. 109: 1. PMID 29861383 DOI: 10.1016/J.Cyto.2018.04.036  0.326
2018 Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH. Intracellular Receptor Modulation: Novel Approach to Target GPCRs. Trends in Pharmacological Sciences. PMID 29653834 DOI: 10.1016/J.Tips.2018.03.002  0.459
2018 Taylor BC, Kufareva I, Handel T, Amaro RE. Investigating Chemokine Receptor CCR2 Dynamics and Druggability by Ensemble Based Approaches Biophysical Journal. 114: 399a. DOI: 10.1016/J.Bpj.2017.11.2205  0.321
2017 Proudfoot AEI, Johnson Z, Bonvin P, Handel TM. Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System. Pharmaceuticals (Basel, Switzerland). 10. PMID 28792472 DOI: 10.3390/Ph10030070  0.464
2017 Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ. A Heparan Sulfate Microarray Reveals that Heparan Sulfate-Protein Binding Exhibit Different Ligand Requirements. Journal of the American Chemical Society. PMID 28651046 DOI: 10.1021/Jacs.7B01399  0.448
2017 Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 46: 1005-1017.e5. PMID 28636951 DOI: 10.1016/J.Immuni.2017.05.002  0.376
2017 Kufareva I, Gustavsson M, Zheng Y, Stephens BS, Handel TM. What Do Structures Tell Us About Chemokine Receptor Function and Antagonism? Annual Review of Biophysics. 46: 175-198. PMID 28532213 DOI: 10.1146/Annurev-Biophys-051013-022942  0.447
2017 Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel TM, Richter RP. Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization. Open Biology. 7. PMID 28123055 DOI: 10.1098/Rsob.160286  0.47
2017 Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel TM. Structural basis of ligand interaction with atypical chemokine receptor 3. Nature Communications. 8: 14135. PMID 28098154 DOI: 10.1038/Ncomms14135  0.471
2017 Zheng Y, Qin L, Han GW, Gustavsson M, Kawamura T, Abagyan R, Stevens RC, Cherezov, Kufareva I, Handel TM. Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5 Immunity. DOI: 10.2210/Pdb5Uiw/Pdb  0.339
2016 Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, ... ... Handel TM, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. PMID 27926736 DOI: 10.1038/Nature20605  0.507
2016 Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel TM, Doranz BJ. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proceedings of the National Academy of Sciences of the United States of America. PMID 27543332 DOI: 10.1073/Pnas.1601278113  0.447
2016 Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel TM. The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine:glycosaminoglycan interactions. The Journal of Biological Chemistry. PMID 27044744 DOI: 10.1074/Jbc.M116.720953  0.466
2016 Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel TM. Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes. Methods in Enzymology. 570: 389-420. PMID 26921956 DOI: 10.1016/Bs.Mie.2015.12.001  0.479
2016 Yin X, Johns SC, El Ghazal R, Salanga CL, Handel TM, Fuster MM. Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions. Methods in Enzymology. 570: 335-55. PMID 26921954 DOI: 10.1016/Bs.Mie.2015.09.017  0.392
2016 Gustavsson M, Zheng Y, Handel TM. Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. Methods in Enzymology. 570: 233-260. PMID 26921949 DOI: 10.1016/Bs.Mie.2015.10.003  0.414
2016 Fox JC, Tyler RC, Peterson FC, Dyer DP, Zhang F, Linhardt RJ, Handel TM, Volkman BF. Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer. Biochemistry. PMID 26836755 DOI: 10.1021/Acs.Biochem.5B01329  0.425
2016 Gustavsson M, Zheng Y, Qin L, Holden LG, Kufareva I, Handel TM. Abstract A168: Towards an understanding of the structural basis of CXCR7 ligand binding and signaling Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A168  0.503
2015 Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel TM. The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology. PMID 26582609 DOI: 10.1093/Glycob/Cwv100  0.483
2015 Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP. Cytokines and growth factors cross-link heparan sulfate. Open Biology. 5. PMID 26269427 DOI: 10.1098/Rsob.150046  0.418
2015 Kufareva I, Handel TM, Abagyan R. Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods in Molecular Biology (Clifton, N.J.). 1335: 295-311. PMID 26260608 DOI: 10.1007/978-1-4939-2914-6_19  0.423
2015 Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel TM. Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines. The Journal of Biological Chemistry. 290: 22385-97. PMID 26216880 DOI: 10.1074/Jbc.M115.675108  0.798
2015 Deshauer C, Morgan AM, Ryan EO, Handel TM, Prestegard JH, Wang X. Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands. Structure (London, England : 1993). 23: 1066-77. PMID 25982530 DOI: 10.1016/J.Str.2015.03.024  0.437
2015 Kufareva I, Salanga CL, Handel TM. Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunology and Cell Biology. 93: 372-83. PMID 25708536 DOI: 10.1038/Icb.2015.15  0.487
2015 Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science (New York, N.Y.). 347: 1117-22. PMID 25612609 DOI: 10.1126/Science.1261064  0.474
2015 Handel TM. The structure of a CXCR4: Chemokine complex Frontiers in Immunology. 6. DOI: 10.3389/Fimmu.2015.00282  0.378
2015 Bacon K, Moss E, Bingham K, Boulet L, Fitzgerald M, Gauvreau G, O'Byrne P, Gilliland T, Handel T, Ly T, Boehme S. LATE-BREAKING ABSTRACT: A novel role for CCR3 in promoting airways hyperreactivity; Role for CCR3-muscarinic M3 receptor heterodimers European Respiratory Journal. 46. DOI: 10.1183/13993003.Congress-2015.Oa288  0.349
2015 Kufareva I, Abagyan R, Handel TM. Role of 3D structures in understanding, predicting, and designing molecular interactions in the chemokine receptor family Topics in Medicinal Chemistry. 14: 41-86. DOI: 10.1007/7355_2014_77  0.377
2014 Kufareva I, Stephens BS, Holden LG, Qin L, Zhao C, Kawamura T, Abagyan R, Handel TM. Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation. Proceedings of the National Academy of Sciences of the United States of America. 111: E5363-72. PMID 25468967 DOI: 10.1073/Pnas.1417037111  0.47
2014 Bonvin P, Dunn SM, Rousseau F, Dyer DP, Shaw J, Power CA, Handel TM, Proudfoot AE. Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display. The Journal of Biological Chemistry. 289: 31846-55. PMID 25266725 DOI: 10.1074/Jbc.M114.599233  0.501
2014 Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel TM. Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine. The Journal of Biological Chemistry. 289: 14896-912. PMID 24727473 DOI: 10.1074/Jbc.M114.547737  0.464
2014 Verkaar F, van Offenbeek J, van der Lee MM, van Lith LH, Watts AO, Rops AL, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AE, Vischer HF, Zaman GJ, Smit MJ. Chemokine cooperativity is caused by competitive glycosaminoglycan binding. Journal of Immunology (Baltimore, Md. : 1950). 192: 3908-14. PMID 24639348 DOI: 10.4049/Jimmunol.1302159  0.492
2014 Dyer DP, Thomson JM, Hermant A, Jowitt TA, Handel TM, Proudfoot AE, Day AJ, Milner CM. TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8. Journal of Immunology (Baltimore, Md. : 1950). 192: 2177-85. PMID 24501198 DOI: 10.4049/Jimmunol.1300194  0.432
2014 Yin X, Johns SC, Kim D, Mikulski Z, Salanga CL, Handel TM, Macal M, Zúñiga EI, Fuster MM. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. Journal of Immunology (Baltimore, Md. : 1950). 192: 2133-42. PMID 24493818 DOI: 10.4049/Jimmunol.1301286  0.338
2014 Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. A general method for site specific fluorescent labeling of recombinant chemokines. Plos One. 9: e81454. PMID 24489642 DOI: 10.1371/Journal.Pone.0081454  0.404
2013 Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. The Journal of Biological Chemistry. 288: 32194-210. PMID 24056371 DOI: 10.1074/Jbc.M113.503797  0.445
2013 Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. Acs Chemical Biology. 8: 1955-63. PMID 23802178 DOI: 10.1021/Cb400274Z  0.508
2013 Kara EE, Comerford I, Bastow CR, Fenix KA, Litchfield W, Handel TM, McColl SR. Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites. Journal of Immunology (Baltimore, Md. : 1950). 191: 1110-7. PMID 23797668 DOI: 10.4049/Jimmunol.1203089  0.337
2013 Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. Journal of Lipid Research. 54: 1877-83. PMID 23667177 DOI: 10.1194/Jlr.M036343  0.367
2013 Wang X, Sharp JS, Handel TM, Prestegard JH. Chemokine oligomerization in cell signaling and migration. Progress in Molecular Biology and Translational Science. 117: 531-78. PMID 23663982 DOI: 10.1016/B978-0-12-386931-9.00020-9  0.485
2013 O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nature Reviews. Cancer. 13: 412-24. PMID 23640210 DOI: 10.1038/Nrc3521  0.356
2013 Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods in Molecular Biology (Clifton, N.J.). 1013: 93-127. PMID 23625495 DOI: 10.1007/978-1-62703-426-5_7  0.415
2013 Stephens B, Handel TM. Chemokine receptor oligomerization and allostery. Progress in Molecular Biology and Translational Science. 115: 375-420. PMID 23415099 DOI: 10.1016/B978-0-12-394587-7.00009-9  0.443
2013 Webb DR, Handel TM, Kretz-Rommel A, Stevens RC. Opportunities for functional selectivity in GPCR antibodies. Biochemical Pharmacology. 85: 147-52. PMID 22975405 DOI: 10.1016/J.Bcp.2012.08.021  0.425
2012 Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 120: 1742-51. PMID 22791291 DOI: 10.1182/Blood-2012-03-417139  0.364
2011 Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH. Oligomeric structure of the chemokine CCL5/RANTES from NMR, MS, and SAXS data. Structure (London, England : 1993). 19: 1138-48. PMID 21827949 DOI: 10.1016/J.Str.2011.06.001  0.426
2011 Kulig P, Kantyka T, Zabel BA, Banas M, Chyra A, Stefanska A, Tu H, Allen SJ, Handel TM, Kozik A, Potempa J, Butcher EC, Cichy J. Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. Journal of Immunology (Baltimore, Md. : 1950). 187: 1403-10. PMID 21715684 DOI: 10.4049/Jimmunol.1002352  0.405
2011 Allen SJ, Hamel DJ, Handel TM. A rapid and efficient way to obtain modified chemokines for functional and biophysical studies. Cytokine. 55: 168-73. PMID 21632261 DOI: 10.1016/J.Cyto.2011.05.002  0.462
2011 Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, ... ... Handel TM, et al. Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. Journal of Medicinal Chemistry. 54: 1667-81. PMID 21341682 DOI: 10.1021/Jm1012903  0.355
2011 Hanes MS, Reynolds KA, McNamara C, Ghosh P, Bonomo RA, Kirsch JF, Handel TM. Specificity and cooperativity at β-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions. Proteins. 79: 1267-76. PMID 21294157 DOI: 10.1002/Prot.22961  0.789
2011 Salanga CL, Handel TM. Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function Experimental Cell Research. 317: 590-601. PMID 21223963 DOI: 10.1016/J.Yexcr.2011.01.004  0.453
2011 Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel TM, Kipps TJ. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 117: 882-9. PMID 21079155 DOI: 10.1182/Blood-2010-04-282400  0.315
2010 Yin X, Truty J, Lawrence R, Johns SC, Srinivasan RS, Handel TM, Fuster MM. A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis. Molecular Cancer. 9: 316. PMID 21172016 DOI: 10.1186/1476-4598-9-316  0.304
2010 O'Hayre M, Salanga CL, Handel TM, Hamel DJ. Emerging concepts and approaches for chemokine-receptor drug discovery. Expert Opinion On Drug Discovery. 5: 1109-22. PMID 21132095 DOI: 10.1517/17460441.2010.525633  0.341
2010 Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.). 330: 1066-71. PMID 20929726 DOI: 10.1126/Science.1194396  0.475
2010 Hanes MS, Ratcliff K, Marqusee S, Handel TM. Protein-protein binding affinities by pulse proteolysis: application to TEM-1/BLIP protein complexes. Protein Science : a Publication of the Protein Society. 19: 1996-2000. PMID 20669180 DOI: 10.1002/Pro.467  0.803
2010 O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM. Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. Plos One. 5: e11716. PMID 20661426 DOI: 10.1371/Journal.Pone.0011716  0.317
2010 Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T. Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans. The Journal of Biological Chemistry. 285: 17713-24. PMID 20363748 DOI: 10.1074/Jbc.M109.082552  0.824
2010 Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. Structure of the minimal interface between ApoE and LRP. Journal of Molecular Biology. 398: 306-19. PMID 20303980 DOI: 10.1016/J.Jmb.2010.03.022  0.436
2010 Jansma AL, Kirkpatrick JP, Hsu AR, Handel TM, Nietlispach D. NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. The Journal of Biological Chemistry. 285: 14424-37. PMID 20200157 DOI: 10.1074/Jbc.M109.091108  0.812
2009 Hanes MS, Jude KM, Berger JM, Bonomo RA, Handel TM. Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry. 48: 9185-93. PMID 19731932 DOI: 10.1021/Bi9007963  0.782
2009 Hamel DJ, Sielaff I, Proudfoot AE, Handel TM. Chapter 4. Interactions of chemokines with glycosaminoglycans. Methods in Enzymology. 461: 71-102. PMID 19480915 DOI: 10.1016/S0076-6879(09)05404-4  0.51
2009 Jansma A, Handel TM, Hamel DJ. Chapter 2. Homo- and hetero-oligomerization of chemokines. Methods in Enzymology. 461: 31-50. PMID 19480913 DOI: 10.1016/S0076-6879(09)05402-0  0.813
2009 Hamel DJ, Handel TM. Methods to probe the physical characteristics, dynamics, modifications, and interactions of chemokines and chemokine receptors. Preface. Methods in Enzymology. 461: xv. PMID 19480911 DOI: 10.1016/S0076-6879(09)05422-6  0.347
2009 O'Hayre M, Salanga CL, Dorrestein PC, Handel TM. Phosphoproteomic analysis of chemokine signaling networks. Methods in Enzymology. 460: 331-46. PMID 19446733 DOI: 10.1016/S0076-6879(09)05216-1  0.347
2009 Allen SJ, Ribeiro S, Horuk R, Handel TM. Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1. Protein Expression and Purification. 66: 73-81. PMID 19275940 DOI: 10.1016/J.Pep.2009.03.001  0.446
2009 Salanga CL, O'Hayre M, Handel T. Modulation of chemokine receptor activity through dimerization and crosstalk. Cellular and Molecular Life Sciences : Cmls. 66: 1370-86. PMID 19099182 DOI: 10.1007/S00018-008-8666-1  0.43
2009 Winter JM, Jansma AL, Handel TM, Moore BS. Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angewandte Chemie (International Ed. in English). 48: 767-70. PMID 19072974 DOI: 10.1002/Anie.200805140  0.756
2009 Du XY, Zabel BA, Myles T, Allen SJ, Handel TM, Lee PP, Butcher EC, Leung LL. Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. The Journal of Biological Chemistry. 284: 751-8. PMID 19010784 DOI: 10.1074/Jbc.M805000200  0.332
2008 Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. The Journal of Experimental Medicine. 205: 2207-20. PMID 18794339 DOI: 10.1084/Jem.20080300  0.442
2008 Reynolds KA, Hanes MS, Thomson JM, Antczak AJ, Berger JM, Bonomo RA, Kirsch JF, Handel TM. Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. Journal of Molecular Biology. 382: 1265-75. PMID 18775544 DOI: 10.1016/J.Jmb.2008.05.051  0.792
2008 Handel TM, Johnson Z, Rodrigues DH, Dos Santos AC, Cirillo R, Muzio V, Riva S, Mack M, Déruaz M, Borlat F, Vitte PA, Wells TN, Teixeira MM, Proudfoot AE. An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. Journal of Leukocyte Biology. 84: 1101-8. PMID 18662971 DOI: 10.1189/Jlb.0108061  0.363
2008 O'Hayre M, Salanga CL, Handel TM, Allen SJ. Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. The Biochemical Journal. 409: 635-49. PMID 18177271 DOI: 10.1042/Bj20071493  0.373
2007 Allen SJ, Zabel BA, Kirkpatrick J, Butcher EC, Nietlispach D, Handel TM. NMR assignment of human chemerin, a novel chemoattractant. Biomolecular Nmr Assignments. 1: 171-3. PMID 19636857 DOI: 10.1007/S12104-007-9047-7  0.336
2007 Chowdry AB, Reynolds KA, Hanes MS, Voorhies M, Pokala N, Handel TM. An object-oriented library for computational protein design. Journal of Computational Chemistry. 28: 2378-88. PMID 17471459 DOI: 10.1002/Jcc.20727  0.764
2007 Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Science : a Publication of the Protein Society. 16: 695-703. PMID 17384234 DOI: 10.1110/Ps.062720107  0.688
2007 Kulig P, Zabel BA, Dubin G, Allen SJ, Ohyama T, Potempa J, Handel TM, Butcher EC, Cichy J. Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. Journal of Immunology (Baltimore, Md. : 1950). 178: 3713-20. PMID 17339469 DOI: 10.4049/Jimmunol.178.6.3713  0.34
2007 Allen SJ, Crown SE, Handel TM. Chemokine: receptor structure, interactions, and antagonism. Annual Review of Immunology. 25: 787-820. PMID 17291188 DOI: 10.1146/Annurev.Immunol.24.021605.090529  0.819
2007 Du X, Zabel BA, Allen SJ, Handel TM, Lee PP, Butcher EC, Leung LL. Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (TAFIa) and Platelets. Blood. 110: 408-408. DOI: 10.1182/Blood.V110.11.408.408  0.335
2006 Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Experimental Hematology. 34: 1106-14. PMID 16863918 DOI: 10.1016/J.Exphem.2006.03.011  0.364
2006 Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, Butcher EC. Chemoattractants, extracellular proteases, and the integrated host defense response. Experimental Hematology. 34: 1021-32. PMID 16863908 DOI: 10.1016/J.Exphem.2006.05.003  0.339
2006 Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. The Journal of Biological Chemistry. 281: 26745-53. PMID 16809340 DOI: 10.1074/Jbc.M603878200  0.801
2006 Crown SE, Yu Y, Sweeney MD, Leary JA, Handel TM. Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. The Journal of Biological Chemistry. 281: 25438-46. PMID 16803905 DOI: 10.1074/Jbc.M601518200  0.809
2006 Yu Y, Sweeney MD, Saad OM, Crown SE, Handel TM, Leary JA. Potential Inhibitors of Chemokine Function: Analysis of Noncovalent Complexes of CC Chemokine and Small Polyanionic Molecules by ESI FT-ICR Mass Spectrometry (DOI:10.1016/j.jasms.2005.12.008) Journal of the American Society For Mass Spectrometry. 17: 1040. DOI: 10.1016/J.Jasms.2006.04.027  0.759
2005 Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, Butcher EC. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. The Journal of Biological Chemistry. 280: 34661-6. PMID 16096270 DOI: 10.1074/Jbc.M504868200  0.364
2005 Yu Y, Sweeney MD, Saad OM, Crown SE, Hsu AR, Handel TM, Leary JA. Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry. The Journal of Biological Chemistry. 280: 32200-8. PMID 16033763 DOI: 10.1074/Jbc.M505738200  0.798
2005 Johnson Z, Proudfoot AE, Handel TM. Interaction of chemokines and glycosaminoglycans: A new twist in the regulation of chemokine function with opportunities for therapeutic intervention Cytokine and Growth Factor Reviews. 16: 625-636. PMID 15990353 DOI: 10.1016/J.Cytogfr.2005.04.006  0.42
2005 Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. Regulation of protein function by glycosaminoglycans--as exemplified by chemokines. Annual Review of Biochemistry. 74: 385-410. PMID 15952892 DOI: 10.1146/Annurev.Biochem.72.121801.161747  0.794
2005 Huang D, Wujek J, Kidd G, He TT, Cardona A, Sasse ME, Stein EJ, Kish J, Tani M, Charo IF, Proudfoot AE, Rollins BJ, Handel T, Ransohoff RM. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 761-72. PMID 15857890 DOI: 10.1096/Fj.04-3104Com  0.338
2005 Pokala N, Handel TM. Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity. Journal of Molecular Biology. 347: 203-27. PMID 15733929 DOI: 10.1016/J.Jmb.2004.12.019  0.766
2005 Sandhoff R, Grieshaber H, Djafarzadeh R, Sijmonsma TP, Proudfoot AE, Handel TM, Wiegandt H, Nelson PJ, Gröne HJ. Chemokines bind to sulfatides as revealed by surface plasmon resonance. Biochimica Et Biophysica Acta. 1687: 52-63. PMID 15708353 DOI: 10.1016/J.Bbalip.2004.11.011  0.449
2004 Lau EK, Allen S, Hsu AR, Handel TM. Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins. Advances in Protein Chemistry. 68: 351-91. PMID 15500866 DOI: 10.1016/S0065-3233(04)68010-7  0.805
2004 Lau EK, Paavola CD, Johnson Z, Gaudry JP, Geretti E, Borlat F, Kungl AJ, Proudfoot AE, Handel TM. Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. The Journal of Biological Chemistry. 279: 22294-305. PMID 15033992 DOI: 10.1074/Jbc.M311224200  0.762
2004 Pokala N, Handel TM. Energy functions for protein design I: efficient and accurate continuum electrostatics and solvation. Protein Science : a Publication of the Protein Society. 13: 925-36. PMID 15010542 DOI: 10.1110/Ps.03486104  0.747
2004 Handel TM, Lau EK. Chemokine structure and receptor interactions. Ernst Schering Research Foundation Workshop. 101-24. PMID 14699797  0.724
2004 Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 81-90. PMID 14647401 DOI: 10.1038/Labinvest.3700007  0.704
2003 Seet BT, McCaughan CA, Handel TM, Mercer A, Brunetti C, McFadden G, Fleming SB. Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proceedings of the National Academy of Sciences of the United States of America. 100: 15137-42. PMID 14657392 DOI: 10.1073/Pnas.2336648100  0.432
2003 Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I, Borlat F, Wells TN, Kosco-Vilbois MH. Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proceedings of the National Academy of Sciences of the United States of America. 100: 1885-90. PMID 12571364 DOI: 10.1073/Pnas.0334864100  0.78
2002 Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH. Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell. 111: 343-56. PMID 12419245 DOI: 10.1016/S0092-8674(02)01007-3  0.742
2002 Lougheed JC, Domaille PJ, Handel TM. Solution structure and dynamics of melanoma inhibitory activity protein. Journal of Biomolecular Nmr. 22: 211-23. PMID 11991352 DOI: 10.1023/A:1014961408029  0.781
2001 Pokala N, Handel TM. Review: Protein design - Where we were, where we are, where we're going Journal of Structural Biology. 134: 269-281. PMID 11551185 DOI: 10.1006/Jsbi.2001.4349  0.756
2001 Seet BT, Singh R, Paavola C, Lau EK, Handel TM, McFadden G. Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 98: 9008-13. PMID 11470923 DOI: 10.1073/Pnas.171069398  0.794
2001 Mizoue LS, Sullivan SK, King DS, Kledal TN, Schwartz TW, Bacon KB, Handel TM. Molecular Determinants of Receptor Binding and Signaling by the CX3C Chemokine Fractalkine Journal of Biological Chemistry. 276: 33906-33914. PMID 11432858 DOI: 10.1074/Jbc.M101348200  0.487
2001 Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM. Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 5515-20. PMID 11331761 DOI: 10.1073/Pnas.091601698  0.772
2001 Marcaurelle LA, Mizoue LS, Wilken J, Oldham L, Kent SB, Handel TM, Bertozzi CR. Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 1129-32. PMID 11303872 DOI: 10.1002/1521-3765(20010302)7:5<1129::Aid-Chem1129>3.0.Co;2-W  0.305
2000 Hoover DM, Mizoue LS, Handel TM, Lubkowski J. The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement Journal of Biological Chemistry. 275: 23187-23193. PMID 10770945 DOI: 10.1074/Jbc.M002584200  0.399
1999 Lazar GA, Johnson EC, Desjarlais JR, Handel TM. Rotamer strain as a determinant of protein structural specificity. Protein Science : a Publication of the Protein Society. 8: 2598-610. PMID 10631975 DOI: 10.1110/Ps.8.12.2598  0.386
1999 Chamberlain AK, Fischer KF, Reardon D, Handel TM, Marqusee AS. Folding of an isolated ribonuclease H core fragment. Protein Science : a Publication of the Protein Society. 8: 2251-7. PMID 10595528 DOI: 10.1110/Ps.8.11.2251  0.32
1999 Jarnagin K, Grunberger D, Mulkins M, Wong B, Hemmerich S, Paavola C, Bloom A, Bhakta S, Diehl F, Freedman R, McCarley D, Polsky I, Ping-Tsou A, Kosaka A, Handel TM. Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2. Biochemistry. 38: 16167-77. PMID 10587439 DOI: 10.1021/Bi9912239  0.451
1999 Hemmerich S, Paavola C, Bloom A, Bhakta S, Freedman R, Grunberger D, Krstenansky J, Lee S, McCarley D, Mulkins M, Wong B, Pease J, Mizoue L, Mirzadegan T, Polsky I, ... ... Handel TM, et al. Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2. Biochemistry. 38: 13013-25. PMID 10529171 DOI: 10.1021/Bi991029M  0.476
1999 Johnson EC, Lazar GA, Desjarlais JR, Handel TM. Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin. Structure (London, England : 1993). 7: 967-76. PMID 10467150 DOI: 10.1016/S0969-2126(99)80123-3  0.38
1999 Desjarlais JR, Handel TM. Side-chain and backbone flexibility in protein core design. Journal of Molecular Biology. 290: 305-18. PMID 10388574 DOI: 10.1006/Jmbi.1999.2866  0.361
1999 Mizoue LS, Bazan JF, Johnson EC, Handel TM. Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. Biochemistry. 38: 1402-14. PMID 9931005 DOI: 10.1021/Bi9820614  0.466
1998 Lazar GA, Handel TM. Hydrophobic core packing and protein design Current Opinion in Chemical Biology. 2: 675-679. PMID 9914192 DOI: 10.1016/S1367-5931(98)80102-6  0.355
1998 Paavola CD, Hemmerich S, Grunberger D, Polsky I, Bloom A, Freedman R, Mulkins M, Bhakta S, McCarley D, Wiesent L, Wong B, Jarnagin K, Handel TM. Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. The Journal of Biological Chemistry. 273: 33157-65. PMID 9837883 DOI: 10.1074/Jbc.273.50.33157  0.478
1998 Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Science : a Publication of the Protein Society. 7: 1404-14. PMID 9655345 DOI: 10.1002/Pro.5560070617  0.554
1997 Davis JH, Agard DA, Handel TM, Basus VJ. Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. Journal of Biomolecular Nmr. 10: 21-7. PMID 9335113 DOI: 10.1023/A:1018314808361  0.396
1997 Lazar GA, Desjarlais JR, Handel TM. De novo design of the hydrophobic core of ubiquitin Protein Science. 6: 1167-1178. PMID 9194177 DOI: 10.1002/Pro.5560060605  0.412
1997 Fairman R, Beran-Steed RK, Handel TM. Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region-helix-loop-helix domain of E47 Protein Science. 6: 175-184. PMID 9007990 DOI: 10.1002/Pro.5560060120  0.632
1997 Lubkowski J, Bujacz G, Boqué L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions Nature Structural Biology. 4: 64-69. PMID 8989326 DOI: 10.1038/Nsb0197-64  0.337
1997 Chamberlain AK, Handel TM, Marqusee S. Detection of protein unfolding and fluctuations by native state hydrogen exchange Techniques in Protein Chemistry. 8: 727-734. DOI: 10.1016/S1080-8914(97)80071-3  0.35
1996 Chamberlain AK, Handel TM, Marqusee S. Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH. Nature Structural Biology. 3: 782-7. PMID 8784352 DOI: 10.1038/Nsb0996-782  0.373
1996 Handel TM, Domaille PJ. Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer Biochemistry. 35: 6569-6584. PMID 8639605 DOI: 10.1021/Bi9602270  0.421
1995 Desjarlais JR, Handel TM. De novo design of the hydrophobic cores of proteins Protein Science. 4: 2006-2018. PMID 8535237 DOI: 10.1002/Pro.5560041006  0.392
1995 Desjarlais JR, Handel TM. New strategies in protein design Current Opinion in Biotechnology. 6: 460-466. PMID 7579657 DOI: 10.1016/0958-1669(95)80076-X  0.416
1993 Handel TM, Williams SA, DeGrado WF. Metal ion-dependent modulation of the dynamics of a designed protein Science. 261: 879-885. PMID 8346440 DOI: 10.1126/Science.8346440  0.583
1993 Handel TM, Williams SA, Menyhard D, DeGrado WF. Introduction of a Trp residue into .alpha.4 as a probe of dynamics Journal of the American Chemical Society. 115: 4457-4460. DOI: 10.1021/Ja00064A006  0.538
1992 Osterhout JJ, Handel T, Na G, Toumadje A, Long RC, Connolly PJ, Hoch JC, Johnson WC, Live D, DeGrado WF. Characterization of the structural properties of .alpha.1B, a peptide designed to form a four-helix bundle Journal of the American Chemical Society. 114: 331-337. DOI: 10.1021/Ja00027A043  0.444
1990 Handel T. De novo design of an alpha/beta barrel protein. Protein Engineering. 3: 233-4. PMID 2188260 DOI: 10.1093/Protein/3.4.233  0.301
1990 Handel T, DeGrado WF. De novo design of a Zn2+-binding protein Journal of the American Chemical Society. 112: 6710-6711. DOI: 10.1021/Ja00174A039  0.553
1989 Roerdink FH, Regts J, Handel T, Sullivan SM, Baldeschwieler JD, Scherphof GL. Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and gamma-ray perturbed angular correlation study. Biochimica Et Biophysica Acta. 980: 234-40. PMID 2930790 DOI: 10.1016/0005-2736(89)90404-5  0.547
1988 Goodrich RP, Handel TM, Baldeschwieler JD. Modification of lipid phase behavior with membrane-bound cryoprotectants. Biochimica Et Biophysica Acta. 938: 143-54. PMID 3342228 DOI: 10.1016/0005-2736(88)90154-X  0.55
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