| Year |
Citation |
Score |
| 2024 |
Li Y, Abel HJ, Cai M, LaValle TA, Yin T, Helton NM, Smith AM, Miller CA, Ley TJ. Rapid and accurate remethylation of DNA in deficient hematopoietic cells with restoration of DNMT3A activity. Science Advances. 10: eadk8598. PMID 38295174 DOI: 10.1126/sciadv.adk8598 |
0.351 |
|
| 2023 |
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Nonavinkere Srivatsan S, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, ... ... Ley TJ, et al. Genomic landscape of TP53-mutated myeloid malignancies. Blood Advances. PMID 37339484 DOI: 10.1182/bloodadvances.2023010156 |
0.692 |
|
| 2023 |
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Srivatsan SN, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, ... ... Ley TJ, et al. Genomic landscape of -mutated myeloid malignancies. Medrxiv : the Preprint Server For Health Sciences. PMID 36711871 DOI: 10.1101/2023.01.10.23284322 |
0.68 |
|
| 2022 |
Kramer MH, Zhang Q, Sprung R, Day RB, Erdmann-Gilmore P, Li Y, Xu Z, Helton NM, George DR, Mi Y, Westervelt P, Payton JE, Ramakrishnan SM, Miller CA, Link DC, ... ... Ley TJ, et al. Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia. Blood. PMID 35895896 DOI: 10.1182/blood.2022016033 |
0.663 |
|
| 2022 |
Petti AA, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ. Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing. Nature Communications. 13: 4216. PMID 35864110 DOI: 10.1038/s41467-022-31995-w |
0.303 |
|
| 2022 |
Menssen AJ, Khanna A, Miller CA, Nonavinkere Srivatsan S, Chang GS, Shao J, Robinson J, O'Laughlin M, Fronick CC, Fulton RS, Brendel K, Heath SE, Saba R, Welch JS, Spencer DH, ... ... Ley TJ, et al. Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression. Blood Cancer Discovery. OF1-OF16. PMID 35709710 DOI: 10.1158/2643-3230.BCD-21-0155 |
0.688 |
|
| 2022 |
Li S, Yao JC, Oetjen KA, Krambs JR, Xia J, Zhang J, Schmidt AP, Helton NM, Fulton RS, Heath SE, Turnbull IR, Mbalaviele G, Ley TJ, Walter MJ, Link DC. IL-1b expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function. Blood. PMID 35675516 DOI: 10.1182/blood.2022016084 |
0.777 |
|
| 2022 |
Upadhyay P, Beales J, Shah NM, Gruszczynska A, Miller CA, Petti AA, Ramakrishnan SM, Link DC, Ley TJ, Welch JS. Recurrent Transcriptional Responses in AML and MDS patients Treated with Decitabine. Experimental Hematology. PMID 35429619 DOI: 10.1016/j.exphem.2022.04.002 |
0.642 |
|
| 2022 |
Smith AM, Verdoni AM, Abel HJ, Chen DY, Ketkar S, Leight ER, Miller CA, Ley TJ. Somatic inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells. Iscience. 25: 104004. PMID 35313694 DOI: 10.1016/j.isci.2022.104004 |
0.316 |
|
| 2022 |
Ferraro F, Gruszczynska A, Ruzinova MB, Miller CA, Percival ME, Uy GL, Pusic I, Jacoby MA, Christopher MJ, Kim MY, Westervelt P, Cashen AF, Schroeder MA, DiPersio JF, Abboud CN, ... ... Ley TJ, et al. Decitabine salvage for Tumor Protein P53mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy. Haematologica. PMID 35236053 DOI: 10.3324/haematol.2021.280153 |
0.604 |
|
| 2022 |
Miller CA, Walker JR, Jensen TL, Hooper WF, Fulton RS, Painter JS, Sekeres MA, Ley TJ, Spencer DH, Goll JB, Walter MJ. Failure to detect mutations in U2AF1 due to changes in the GRCh38 reference sequence. The Journal of Molecular Diagnostics : Jmd. PMID 35041928 DOI: 10.1016/j.jmoldx.2021.10.013 |
0.305 |
|
| 2022 |
Petti AA, Khan SM, Xu Z, Helton N, Fronick CC, Fulton R, Ramakrishnan SM, Nonavinkere Srivatsan S, Heath SE, Westervelt P, Payton JE, Walter MJ, Link DC, DiPersio J, Miller C, ... Ley TJ, et al. Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia. Blood Cancer Discovery. 3: 32-49. PMID 35019859 DOI: 10.1158/2643-3230.BCD-21-0050 |
0.677 |
|
| 2021 |
Wilson ER, Helton NM, Heath SE, Fulton RS, Payton JE, Welch JS, Walter MJ, Westervelt P, DiPersio JF, Link DC, Miller CA, Ley TJ, Spencer DH. Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells. Leukemia. PMID 34873300 DOI: 10.1038/s41375-021-01476-y |
0.677 |
|
| 2021 |
Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, ... ... Ley TJ, et al. Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34845035 DOI: 10.1073/pnas.2116427118 |
0.822 |
|
| 2021 |
Ferris MA, Smith AM, Heath SE, Duncavage EJ, Oberley MJ, Freyer D, Wynn R, Douzgou S, Maris JM, Reilly AF, Wu M, Choo F, Fiets RB, Koene S, Spencer DH, ... ... Ley TJ, et al. DNMT3A Overgrowth Syndrome is associated with the development of hematopoietic malignancies in children and young adults. Blood. PMID 34788385 DOI: 10.1182/blood.2021014052 |
0.305 |
|
| 2021 |
Christopher MJ, Katerndahl CDS, LeBlanc HR, Elmendorf TT, Basu V, Gang M, Menssen AJ, Spencer DH, Duncavage EJ, Ketkar S, Wartman LD, Ramakrishnan SM, Miller CA, Ley TJ. Tumor suppressor function of in acute promyelocytic leukemia. Haematologica. PMID 34670359 DOI: 10.3324/haematol.2021.279601 |
0.734 |
|
| 2021 |
Smith AM, LaValle TA, Shinawi M, Ramakrishnan SM, Abel HJ, Hill CA, Kirkland NM, Rettig MP, Helton NM, Heath SE, Ferraro F, Chen DY, Adak S, Semenkovich CF, Christian DL, ... ... Ley TJ, et al. Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome. Nature Communications. 12: 4549. PMID 34315901 DOI: 10.1038/s41467-021-24800-7 |
0.344 |
|
| 2021 |
Katerndahl CDS, Rogers ORS, Day RB, Cai MA, Rooney TP, Helton NM, Hoock M, Ramakrishnan SM, Srivatsan SN, Wartman LD, Miller CA, Ley TJ. Tumor suppressor function of Gata2 in Acute Promyelocytic Leukemia. Blood. PMID 34125173 DOI: 10.1182/blood.2021011758 |
0.367 |
|
| 2021 |
Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, ... ... Ley TJ, et al. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. The New England Journal of Medicine. 384: 924-935. PMID 33704937 DOI: 10.1056/NEJMoa2024534 |
0.802 |
|
| 2020 |
Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, ... ... Ley TJ, et al. The clonal evolution of metastatic colorectal cancer. Science Advances. 6: eaay9691. PMID 32577507 DOI: 10.1126/Sciadv.Aay9691 |
0.313 |
|
| 2020 |
Silva-Fisher JM, Dang HX, White NM, Strand MS, Krasnick BA, Rozycki EB, Jeffers GGL, Grossman JG, Highkin MK, Tang C, Cabanski CR, Eteleeb A, Mudd J, Goedegebuure SP, Luo J, ... ... Ley TJ, et al. Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression. Nature Communications. 11: 2156. PMID 32358485 DOI: 10.1038/S41467-020-15547-8 |
0.312 |
|
| 2020 |
Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight ER, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Ramakrishnan SM, Chang GS, Petti AA, ... ... Ley TJ, et al. Remethylation of hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing. Proceedings of the National Academy of Sciences of the United States of America. PMID 31996479 DOI: 10.1073/Pnas.1918611117 |
0.497 |
|
| 2019 |
Mazzarella L, Botteri E, Matthews A, Gatti E, Di Salvatore D, Bagnardi V, Breccia M, Montesinos P, Bernal T, Gil C, Ley TJ, Sanz M, Bhaskaran K, Lo Coco F, Pelicci PG. Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies studies and correlation with flt3 mutations and polyunsaturated fatty acid metabolism. Haematologica. PMID 31515354 DOI: 10.3324/Haematol.2019.223925 |
0.348 |
|
| 2019 |
Petti AA, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ. A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing. Nature Communications. 10: 3660. PMID 31413257 DOI: 10.1038/S41467-019-11591-1 |
0.475 |
|
| 2019 |
Christopher M, DiPersio JF, Ley TJ. Immune Escape of AML Cells after Transplantation. Reply. The New England Journal of Medicine. 380: 1290. PMID 30917273 DOI: 10.1056/NEJMc1900424#sa3 |
0.734 |
|
| 2019 |
Katerndahl CD, Ley TJ, Cai MA, Rooney TP, Ramakrishnan SM, Nonavinkere Srivatsan S, Miller CA. Gata2 Expression and Function in PML-RARA-driven Preleukemia and APL Blood. 134: 534-534. DOI: 10.1182/Blood-2019-131883 |
0.455 |
|
| 2019 |
Smith AM, LaValle T, Ketkar S, Ramakrishnan SM, Miller CA, Ley TJ. DNMT3AR882 Alters the Epigenome of Hematopoietic Cells Blood. 134: 112-112. DOI: 10.1182/Blood-2019-129003 |
0.502 |
|
| 2019 |
Ferraro F, Miller CA, Abdalla A, Helton N, Salomonis N, Fulton RS, Fronick C, Heath SE, Westervelt P, Ley TJ. The Molecular Basis of Long First Remissions in Normal Karyotype AML Patients Blood. 134: 3827-3827. DOI: 10.1182/Blood-2019-122967 |
0.5 |
|
| 2019 |
Wilson E, Helton N, Fronick C, Fulton R, Welch JS, Ley TJ, Spencer DH. Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML Blood. 134: 3755-3755. DOI: 10.1182/Blood-2019-122340 |
0.452 |
|
| 2018 |
Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, ... ... Ley TJ, et al. Immune Escape of Relapsed AML Cells after Allogeneic Transplantation. The New England Journal of Medicine. PMID 30380364 DOI: 10.1056/Nejmoa1808777 |
0.785 |
|
| 2018 |
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, ... ... Ley TJ, et al. Mutation Clearance after Transplantation for Myelodysplastic Syndrome. The New England Journal of Medicine. 379: 1028-1041. PMID 30207916 DOI: 10.1056/Nejmoa1804714 |
0.817 |
|
| 2018 |
Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty JD, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy P, Link DC. MIR142 loss-of-function mutations derepress ASH1L to increase HOXA gene expression and promote leukemogenesis. Cancer Research. PMID 29724719 DOI: 10.1158/0008-5472.Can-17-3592 |
0.769 |
|
| 2018 |
Chen D, Christopher M, Helton NM, Ferguson I, Ley TJ, Spencer DH. DNMT3A-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AOCI-AML3 leukemia cell line. Blood Cancer Journal. 8: 38. PMID 29618788 DOI: 10.1038/S41408-018-0072-9 |
0.759 |
|
| 2018 |
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, ... ... Ley TJ, et al. Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant. Jci Insight. 3. PMID 29515031 DOI: 10.1172/Jci.Insight.98962 |
0.769 |
|
| 2018 |
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, ... ... Ley TJ, et al. Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential. Nature Communications. 9: 455. PMID 29386642 DOI: 10.1038/S41467-018-02858-0 |
0.815 |
|
| 2018 |
Warner WA, Spencer DH, Trissal M, White BS, Helton N, Ley TJ, Link DC. Expression profiling of snoRNAs in normal hematopoiesis and AML. Blood Advances. 2: 151-163. PMID 29365324 DOI: 10.1182/Bloodadvances.2017006668 |
0.678 |
|
| 2018 |
Petti AA, Williams SR, Miller CA, Fiddes IT, Chen D, Nonavinkere Srivatsan S, Fronick C, Fulton R, Church DM, Ley TJ. Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity Blood. 132: 1314-1314. DOI: 10.1182/Blood-2018-99-119075 |
0.506 |
|
| 2018 |
Ferraro F, Miller CA, Helton N, Fulton RS, Fronick C, Heath SE, Westervelt P, Ley TJ. Evidence for Complete Mutation Clearance in Normal Karyotype AML Patients with Very Long (> 5 years) Remissions after Chemotherapy Alone Blood. 132: 1503-1503. DOI: 10.1182/Blood-2018-99-117288 |
0.472 |
|
| 2018 |
Jacoby M, Spencer DH, Hughes E, Fulton RS, O'Laughlin M, Fronick C, Loken MR, Baty JD, Schroeder MA, Ghobadi A, Uy GL, Vij R, Kahl BS, Cashen AF, Walter MJ, ... ... Ley TJ, et al. Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance Blood. 132: 5277-5277. DOI: 10.1182/Blood-2018-99-114979 |
0.381 |
|
| 2017 |
Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, ... Ley TJ, et al. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. The Journal of Clinical Investigation. PMID 28872462 DOI: 10.1172/Jci93041 |
0.458 |
|
| 2017 |
Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, ... ... Ley TJ, et al. Comprehensive discovery of non-coding RNAs in acute myeloid leukemia cell transcriptomes. Experimental Hematology. PMID 28760689 DOI: 10.1016/J.Exphem.2017.07.008 |
0.614 |
|
| 2017 |
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, ... ... Ley TJ, et al. CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. Cell. PMID 28215704 DOI: 10.1016/J.Cell.2017.01.021 |
0.714 |
|
| 2017 |
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, ... ... Ley TJ, et al. Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy. Blood. PMID 28082444 DOI: 10.1182/Blood-2016-10-745273 |
0.672 |
|
| 2016 |
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, ... ... Ley TJ, et al. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. The New England Journal of Medicine. 375: 2023-2036. PMID 27959731 DOI: 10.1056/Nejmoa1605949 |
0.806 |
|
| 2016 |
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reinick T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, ... ... Ley TJ, et al. Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy. Leukemia. PMID 27740633 DOI: 10.1038/Leu.2016.282 |
0.772 |
|
| 2016 |
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, et al. Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome. Leukemia. PMID 27573557 DOI: 10.1038/Leu.2016.247 |
0.785 |
|
| 2016 |
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, ... ... Ley TJ, et al. Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B lymphoblastic leukemia. Experimental Hematology. PMID 27181063 DOI: 10.1016/J.Exphem.2016.04.011 |
0.818 |
|
| 2016 |
Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ. PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia. The Journal of Clinical Investigation. 126: 85-98. PMID 26595813 DOI: 10.1172/Jci82897 |
0.443 |
|
| 2016 |
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ, et al. Dynamic Changes in MDS Clonal Architecture Following Allogeneic Stem Cell Transplant Blood. 128: 5506-5506. DOI: 10.1182/Blood.V128.22.5506.5506 |
0.791 |
|
| 2016 |
Mazzarella L, Botteri E, Matthews A, Disalvatore D, Bagnardi V, Breccia M, Montesinos P, Bernal T, Gil C, Ley TJ, Sanz MA, Bhaskaran K, Lo Coco F, Pelicci PG. Obesity As a Risk Factor for Acute Promyelocytic Leukemia. Results from Population and Case-Control Studies Across Western Countries and Correlation with Gene Expression in the TCGA Blood. 128: 448-448. DOI: 10.1182/Blood.V128.22.448.448 |
0.325 |
|
| 2016 |
Yao J, Wong TN, Trissal M, Ramaswamy R, Sun Y, Ley TJ, Reddy PR, Link DC. MIR142 Loss-of-Function Mutations Promote Leukemogenesis through Derepression of ASH1L Resulting in Increased HOX Gene Expression Blood. 128: 2718-2718. DOI: 10.1182/Blood.V128.22.2718.2718 |
0.78 |
|
| 2016 |
Christopher M, Petti AA, Miller C, Wartman LD, Payton JE, Heath S, Fulton R, Welch JS, Walter MJ, Westervelt P, Link DC, Wilson RK, Ley TJ, DiPersio JF. Clonal Evolution of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation Blood. 128: 1528-1528. DOI: 10.1182/Blood.V128.22.1528.1528 |
0.833 |
|
| 2016 |
Spencer D, Russler-Germain D, Helton NM, Lamprecht TL, Shinawi M, Westervelt P, Payton JE, Fulton RS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ. DNMT3A-Dependent DNA Methylation May Act As a Tumor Suppressor-Not a Tumor Promoter-during AML Progression Blood. 128: 1050-1050. DOI: 10.1182/Blood.V128.22.1050.1050 |
0.727 |
|
| 2016 |
Ley TJ. Abstract PL03-02: The AML genome(s) Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Pl03-02 |
0.497 |
|
| 2016 |
Chen D, Verdoni A, Ley T. 680 A common acute myeloid leukemia-associated DNMT3A mutation, when expressed ubiquitously in mice, causes reversible alopecia Journal of Investigative Dermatology. 136: S121. DOI: 10.1016/J.Jid.2016.02.722 |
0.417 |
|
| 2015 |
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, ... ... Ley TJ, et al. Patterns and functional implications of rare germline variants across 12 cancer types. Nature Communications. 6: 10086. PMID 26689913 DOI: 10.1038/Ncomms10086 |
0.569 |
|
| 2015 |
Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, ... ... Ley TJ, et al. Optimizing cancer genome sequencing and analysis. Cell Systems. 1: 210-223. PMID 26645048 DOI: 10.7490/F1000Research.1110088.1 |
0.349 |
|
| 2015 |
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, ... ... Ley TJ, et al. Rapid expansion of pre-existing non-leukemic hematopoietic clones frequently follows induction therapy for de novo AML. Blood. PMID 26631115 DOI: 10.1182/Blood-2015-10-677021 |
0.825 |
|
| 2015 |
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, ... ... Ley TJ, et al. Genomic analysis of germline and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. PMID 26492932 DOI: 10.1182/Blood-2015-04-641100 |
0.769 |
|
| 2015 |
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, ... ... Ley TJ, et al. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. Jama. 314: 811-22. PMID 26305651 DOI: 10.1001/Jama.2015.9643 |
0.798 |
|
| 2015 |
Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ. Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse. Plos One. 10: e0120585. PMID 25799070 DOI: 10.1371/Journal.Pone.0120585 |
0.355 |
|
| 2015 |
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE. Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia. 29: 1608-11. PMID 25644247 DOI: 10.1038/Leu.2015.17 |
0.795 |
|
| 2015 |
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ. Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells. Leukemia. 29: 1279-89. PMID 25600023 DOI: 10.1038/Leu.2015.6 |
0.617 |
|
| 2015 |
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, ... ... Ley TJ, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 518: 552-5. PMID 25487151 DOI: 10.1038/Nature13968 |
0.825 |
|
| 2015 |
Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA. U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. Leukemia. 29: 909-17. PMID 25311244 DOI: 10.1038/Leu.2014.303 |
0.811 |
|
| 2015 |
Engle EK, Fisher DA, Miller CA, McLellan MD, Fulton RS, Moore DM, Wilson RK, Ley TJ, Oh ST. Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia. Leukemia. 29: 869-76. PMID 25252869 DOI: 10.1182/Blood.V120.21.706.706 |
0.424 |
|
| 2015 |
Welch JS, Petti A, Miller CA, Link DC, Walter MJ, Fronick CC, Fulton RS, Wartman LD, Uy GL, Ghobadi A, Tomasson M, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein K, ... ... Ley TJ, et al. Dynamic Changes in Clonal Clearance with Decitabine Therapy in AML and MDS Patients Blood. 126: 689-689. DOI: 10.1182/Blood.V126.23.689.689 |
0.696 |
|
| 2015 |
Wong TN, Klco JM, Demeter R, Miller CA, Petti A, Havey N, Fulton R, Heath S, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert T, Wilson RK, ... Ley TJ, et al. Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Cytoreductive Chemotherapy in Adult De Novo AML Patients Blood. 126: 686-686. DOI: 10.1182/Blood.V126.23.686.686 |
0.831 |
|
| 2015 |
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Fulton RS, Fronick CC, O'Laughlin M, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, ... ... Ley TJ, et al. Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy Blood. 126: 610-610. DOI: 10.1182/blood.v126.23.610.610 |
0.779 |
|
| 2015 |
Fehniger TA, Krysiak K, White BS, Matlock M, Miller C, Fulton R, Kreisel F, Fronick C, Cook L, Veizer J, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL, Wilson RK, ... ... Ley TJ, et al. Recurrent Somatic Genomic Alterations in Follicular NHL (FL) Revealed By Exome and Custom-Capture Next Generation Sequencing Blood. 126: 574-574. DOI: 10.1182/Blood.V126.23.574.574 |
0.45 |
|
| 2015 |
Ketkar-Kulkarni S, Verdoni AM, Helton N, Cole CB, Venezia C, Hoock M, Fronick C, O'Laughlin M, Fulton RS, Spencer D, Ley TJ. Specific Patterns of DNA Remethylation in the Bone Marrow Cells of Dnmt3a Deficient Mice after Induced Expression of Wild Type Human DNMT3A Blood. 126: 433-433. DOI: 10.1182/Blood.V126.23.433.433 |
0.4 |
|
| 2015 |
Warner WA, Spencer D, Trissal M, Helton N, Ley TJ, Link DC. Characterization of snoRNA Expression in Acute Myeloid Leukemia Blood. 126: 3649-3649. DOI: 10.1182/Blood.V126.23.3649.3649 |
0.696 |
|
| 2015 |
Verdoni AM, Venezia C, Klco J, Ley TJ. DNMT3A R882H Can Cooperate with FLT3-ITD to Cause AML in Mice Blood. 126: 2458-2458. DOI: 10.1182/Blood.V126.23.2458.2458 |
0.4 |
|
| 2015 |
Spencer D, George DR, Klco JM, Ley TJ. Reprogramming of Leukemic and Pre-Leukemic Cells from Primary Human De Novo Acute Myeloid Leukemia Samples into Induced Pluripotent Stem (iPS) Cells Blood. 126: 1862-1862. DOI: 10.1182/Blood.V126.23.1862.1862 |
0.486 |
|
| 2015 |
Duncavage EJ, O'Brien J, Vij KR, Miller CA, Shao J, Jacoby MA, Fulton RS, Heath S, Janke M, Fronick CC, O'Laughlin M, Wilson RK, Ley TJ, Walter MJ. Detection of Clonal Hematopoiesis in Cytopenic Patients Using Targeted Sequencing Blood. 126: 1654-1654. DOI: 10.1182/Blood.V126.23.1654.1654 |
0.829 |
|
| 2015 |
Yao J, Wong TN, Trissal M, Sun Y, Ley TJ, Reddy P, Link DC. Loss-of-Function Mutations of MIR142 May Contribute to Leukemogenesis By Expanding the Pool of Myeloid-Biased HSCs Blood. 126: 1254-1254. DOI: 10.1182/Blood.V126.23.1254.1254 |
0.776 |
|
| 2015 |
Miller CA, Griffith M, Ramu A, Skidmore ZL, Griffith OL, Magrini V, Demeter R, Dang H, Walker J, Larson DE, Fulton RS, Maher C, Mardis ER, Ley TJ, Wilson RK. Abstract A1-13: Ultra-deep whole-genome sequencing reveals clinically relevant low-frequency subclones in an acute myeloid leukemia Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-13 |
0.428 |
|
| 2015 |
Grossman JG, Strand M, Dang H, White B, Fleming T, Goedegebuure P, Lockhart A, Lim K, Ley T, Wilson R, Mardis E, Maher C, Fields R. Abstract 3878: A model to assess clonal evolution of metastatic colorectal cancer during chemotherapy utilizing patient derived xenografts Cancer Research. 75: 3878-3878. DOI: 10.1158/1538-7445.Am2015-3878 |
0.315 |
|
| 2015 |
Silva-Fisher JM, Dang H, Grossman J, White N, Cabanski C, Goedegebuure S, Fleming T, Pittman E, Fulton R, Strand M, Lockhart AC, Ley T, Wilson R, Fields R, Maher C. Abstract 169: Metastatic colorectal cancer associated long non-coding RNAs identified by transcriptome sequencing of matched primary and metastatic patient tissues Cancer Research. 75: 169-169. DOI: 10.1158/1538-7445.Am2015-169 |
0.322 |
|
| 2014 |
Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, ... ... Ley TJ, et al. Clonal architectures and driver mutations in metastatic melanomas. Plos One. 9: e111153. PMID 25393105 DOI: 10.1371/Journal.Pone.0111153 |
0.45 |
|
| 2014 |
Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA. Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. Blood. 124: 3887-95. PMID 25349173 DOI: 10.1182/Blood-2014-06-582551 |
0.792 |
|
| 2014 |
Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, ... ... Ley TJ, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nature Medicine. 20: 1472-8. PMID 25326804 DOI: 10.1038/Nm.3733 |
0.712 |
|
| 2014 |
Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, et al. SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. Plos Computational Biology. 10: e1003665. PMID 25102416 DOI: 10.1371/Journal.Pcbi.1003665 |
0.62 |
|
| 2014 |
Sarkaria SM, Christopher MJ, Klco JM, Ley TJ. Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro. Leukemia. 28: 2403-6. PMID 25092143 DOI: 10.1038/Leu.2014.235 |
0.798 |
|
| 2014 |
Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, ... ... Ley TJ, et al. Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. Plos Genetics. 10: e1004462. PMID 25010716 DOI: 10.1371/Journal.Pgen.1004462 |
0.763 |
|
| 2014 |
Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 25: 442-54. PMID 24656771 DOI: 10.1016/J.Ccr.2014.02.010 |
0.65 |
|
| 2014 |
Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, ... ... Ley TJ, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 25: 379-92. PMID 24613412 DOI: 10.1016/J.Ccr.2014.01.031 |
0.757 |
|
| 2014 |
Cole CB, Verdoni AM, Chang GS, Miller C, Ley TJ. Myeloproliferative Disease and Myeloid Leukemia in Dnmt3a Haploinsufficient Mice Blood. 124: 890-890. DOI: 10.1182/Blood.V124.21.890.890 |
0.47 |
|
| 2014 |
Verdoni AM, Cole CB, Ketkar-Kulkarni S, Lamprecht T, Havey N, Spencer DH, Ley TJ. DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice Blood. 124: 609-609. DOI: 10.1182/Blood.V124.21.609.609 |
0.409 |
|
| 2014 |
Spencer DH, Al-Khalil B, Russler-Germain D, Lamprecht T, Havey N, Fulton RS, O'Laughlin M, Fronick C, Wilson RK, Ley TJ. Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin Blood. 124: 608-608. DOI: 10.1182/Blood.V124.21.608.608 |
0.443 |
|
| 2014 |
Ketkar-Kulkarni S, Cole CB, Spencer DH, Verdoni AM, Havey N, Lamprecht T, Magrini V, Demeter RT, Wilson RK, Ley TJ. Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara Blood. 124: 3531-3531. DOI: 10.1182/Blood.V124.21.3531.3531 |
0.394 |
|
| 2014 |
Young A, Wong TN, Ley TJ, Link DC, Druley TE. Rare Hematopoietic Subclones Harboring Leukemogenic TP53 Mutations Are Detectable Via Error-Corrected Sequencing in Healthy Elderly Individuals Blood. 124: 2907-2907. DOI: 10.1182/Blood.V124.21.2907.2907 |
0.812 |
|
| 2013 |
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS, Walter MJ, Wendl MC, ... Ley TJ, et al. Mutational landscape and significance across 12 major cancer types. Nature. 502: 333-9. PMID 24132290 DOI: 10.1038/Nature12634 |
0.417 |
|
| 2013 |
Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, ... ... Ley TJ, et al. DGIdb: mining the druggable genome. Nature Methods. 10: 1209-10. PMID 24122041 DOI: 10.1038/Nmeth.2689 |
0.305 |
|
| 2013 |
Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC. Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. Blood. 122: e44-51. PMID 24009227 DOI: 10.1182/Blood-2013-03-488007 |
0.647 |
|
| 2013 |
Chen K, Navin NE, Wang Y, Schmidt HK, Wallis JW, Niu B, Fan X, Zhao H, McLellan MD, Hoadley KA, Mardis ER, Ley TJ, Perou CM, Wilson RK, Ding L. BreakTrans: uncovering the genomic architecture of gene fusions. Genome Biology. 14: R87. PMID 23972288 DOI: 10.1186/Gb-2013-14-8-R87 |
0.335 |
|
| 2013 |
Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson G, Hoadley K, Triche TJ, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia New England Journal of Medicine. 368: 2059-2074. PMID 23634996 DOI: 10.1056/Nejmoa1301689 |
0.438 |
|
| 2013 |
Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ. Notch signaling in acute promyelocytic leukemia. Leukemia. 27: 1548-57. PMID 23455394 DOI: 10.1038/Leu.2013.68 |
0.718 |
|
| 2013 |
Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, ... ... Ley TJ, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 27: 1275-82. PMID 23443460 DOI: 10.1038/Leu.2013.58 |
0.784 |
|
| 2013 |
Klco JM, Spencer DH, Lamprecht TL, Sarkaria SM, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Erdmann-Gilmore P, Lichti CF, Meyer MR, Townsend RR, Wilson RK, Mardis ER, ... Ley TJ, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 121: 1633-43. PMID 23297133 DOI: 10.1182/Blood-2012-09-459313 |
0.401 |
|
| 2013 |
Klco JM, Spencer DH, Miller CA, Lamprecht T, George D, Fulton RS, Wilson RK, Ley TJ. Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice Blood. 122: 609-609. DOI: 10.1182/Blood.V122.21.609.609 |
0.4 |
|
| 2013 |
Neal Wong T, Ramsingh G, Young A, Shen D, Miller C, Lamprecht T, Heath S, Fulton RS, Mardis ER, Ding L, Westervelt P, Welch J, Walter MJ, Graubert T, DiPersio JF, ... Ley TJ, et al. The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML Blood. 122: 5-5. DOI: 10.1182/Blood.V122.21.5.5 |
0.779 |
|
| 2013 |
Verdoni AM, Cole CB, Klco JM, Ley TJ. DNMT3A R882H Overexpression Leads To Hematopoietic and Skin Alterations In Transgenic Mice Blood. 122: 479-479. DOI: 10.1182/Blood.V122.21.479.479 |
0.352 |
|
| 2013 |
Cole CB, Verdoni AM, Spencer DH, Ley TJ. Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA Blood. 122: 477-477. DOI: 10.1182/Blood.V122.21.477.477 |
0.401 |
|
| 2013 |
Trissal M, Silva J, Wylie T, Hundal J, McGrath S, Magrini V, Ramsingh G, Mardis ER, Ley TJ, Link DC. Dysregulation and Recurrent Mutation Of miRNA-142 In De Novo AML Blood. 122: 472-472. DOI: 10.1182/Blood.V122.21.472.472 |
0.652 |
|
| 2013 |
Russler-Germain DA, Spencer DH, Young MA, Lamprecht T, Miller C, Fulton RS, Gilmore P, Townsend R, Ley TJ. R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A Blood. 122: 3812-3812. DOI: 10.1182/Blood.V122.21.3812.3812 |
0.631 |
|
| 2013 |
Spencer DH, Young MA, Klco JM, Ley TJ. Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations Blood. 122: 2496-2496. DOI: 10.1182/Blood.V122.21.2496.2496 |
0.645 |
|
| 2013 |
Li C, George DR, Helton NM, Klco JM, Mudd JL, Ley TJ. Functional Early Hematopoietic Progenitor Cells Derived From Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells Blood. 122: 2421-2421. DOI: 10.1182/Blood.V122.21.2421.2421 |
0.367 |
|
| 2013 |
Dees ND, Miller CA, White BS, Schierding W, Vij R, Tomasson MH, Welch JS, Graubert TA, Walter MJ, Ley TJ, DiPersio JF, Mardis ER, Wilson RK, Ding L. Abstract LB-232: Tumor clonality detection using next generation sequencing data. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-232 |
0.603 |
|
| 2012 |
Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, ... ... Ley TJ, et al. An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell. 22: 683-97. PMID 23153540 DOI: 10.1016/J.Ccr.2012.10.007 |
0.412 |
|
| 2012 |
Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ. Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice. Plos One. 7: e46529. PMID 23056333 DOI: 10.1371/Journal.Pone.0046529 |
0.376 |
|
| 2012 |
Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 150: 264-78. PMID 22817890 DOI: 10.1016/J.Cell.2012.06.023 |
0.789 |
|
| 2012 |
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, ... ... Ley TJ, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 486: 353-60. PMID 22722193 DOI: 10.1038/Nature11143 |
0.412 |
|
| 2012 |
Downing JR, Wilson RK, Zhang J, Mardis ER, Pui CH, Ding L, Ley TJ, Evans WE. The Pediatric Cancer Genome Project. Nature Genetics. 44: 619-22. PMID 22641210 DOI: 10.1038/Ng.2287 |
0.445 |
|
| 2012 |
Chen K, Wallis JW, Kandoth C, Kalicki-Veizer JM, Mungall KL, Mungall AJ, Jones SJ, Marra MA, Ley TJ, Mardis ER, Wilson RK, Weinstein JN, Ding L. BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data. Bioinformatics (Oxford, England). 28: 1923-4. PMID 22563071 DOI: 10.1093/Bioinformatics/Bts272 |
0.317 |
|
| 2012 |
Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik KM, Chen K, Fan X, Schmidt H, Kalicki-Veizer J, Cook LL, Swift GW, Demeter RT, ... ... Ley TJ, et al. Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell. 10: 570-82. PMID 22542160 DOI: 10.1016/J.Stem.2012.03.002 |
0.609 |
|
| 2012 |
Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidt H, Kalicki-Veizer J, O'Laughlin M, ... ... Ley TJ, et al. Clonal architecture of secondary acute myeloid leukemia. The New England Journal of Medicine. 366: 1090-8. PMID 22417201 DOI: 10.1056/Nejmoa1106968 |
0.786 |
|
| 2012 |
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, ... ... Ley TJ, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 481: 157-63. PMID 22237106 DOI: 10.1038/Nature10725 |
0.483 |
|
| 2012 |
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 481: 506-10. PMID 22237025 DOI: 10.1038/Nature10738 |
0.827 |
|
| 2012 |
Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, ... ... Ley TJ, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nature Genetics. 44: 53-7. PMID 22158538 DOI: 10.1038/Ng.1031 |
0.824 |
|
| 2012 |
Larson DE, Harris CC, Chen K, Koboldt DC, Abbott TE, Dooling DJ, Ley TJ, Mardis ER, Wilson RK, Ding L. SomaticSniper: identification of somatic point mutations in whole genome sequencing data. Bioinformatics (Oxford, England). 28: 311-7. PMID 22155872 DOI: 10.1093/Bioinformatics/Btr665 |
0.391 |
|
| 2012 |
Mardis ER, Ding L, Westervelt P, Welch JS, Klco JM, DiPersio JF, Wilson RK, Ley TJ. Next-Generation Sequencing: A Discovery Tool for Blood Disorders Blood. 120: SCI-10-SCI-10. DOI: 10.1182/Blood.V120.21.Sci-10.Sci-10 |
0.469 |
|
| 2012 |
Ramsingh G, Shen D, Lamprecht T, Heath S, Fulton RS, Mardis ER, Ding L, Westervelt P, Welch JS, Walter MJ, Graubert T, DiPersio JF, Ley TJ, Wilson RK, Link DC. Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia Blood. 120: 784-784. DOI: 10.1182/Blood.V120.21.784.784 |
0.787 |
|
| 2012 |
Fisher DA, Miller CA, McLellan MD, Fulton RS, Martin KL, Kaiwar C, Moore DM, Ley TJ, Oh ST. Clonal Evolution Revealed by Whole Genome Sequencing in a Case of Primary Myelofibrosis Transformed to Secondary Acute Myeloid Leukemia Blood. 120: 706-706. DOI: 10.1182/blood.V120.21.706.706 |
0.369 |
|
| 2012 |
Klco JM, Spencer DH, Miller C, Lamprecht T, Fulton RS, Welch JS, Ding L, Wilson RK, Ley TJ. Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse Blood. 120: 407-407. DOI: 10.1182/Blood.V120.21.407.407 |
0.46 |
|
| 2012 |
Trissal M, Spencer DH, Silva J, Wylie T, Hundal J, McGrath S, Magrini V, Ramsingh G, Wilson RJ, Ley TJ, Link DC. Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia Blood. 120: 3500-3500. DOI: 10.1182/Blood.V120.21.3500.3500 |
0.676 |
|
| 2012 |
Tomasson MH, Shen D, Hucthagowder V, Schierding W, Mullins CD, Fiala M, Hall IM, Wallis J, Fulton RS, Fulton LA, Kulkarni S, Mardis ER, Wilson RK, Ley TJ, DiPersio JF, et al. Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma Blood. 120: 320-320. DOI: 10.1182/Blood.V120.21.320.320 |
0.494 |
|
| 2012 |
Spencer DH, Klco JM, Lamprecht T, Wylie T, Magrini V, Hundal J, Walker J, Varghese N, Meyer MR, Gilmore P, Townsend R, Mardis ER, Ley TJ. In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples. Blood. 120: 2527-2527. DOI: 10.1182/Blood.V120.21.2527.2527 |
0.364 |
|
| 2012 |
Li C, George DR, Havey NM, Klco JM, Ley TJ. Functional Hematopoietic Cells Derived From Mouse Embryonic Stem Cells. Blood. 120: 2304-2304. DOI: 10.1182/Blood.V120.21.2304.2304 |
0.349 |
|
| 2012 |
Germain DA, Lamprecht T, Young M, Ley TJ. The De Novo DNA Methylation Activity of WT DNMT3A Is Inhibited by R882H DNMT3A and DNMT3B3 in Vitro Blood. 120: 1329-1329. DOI: 10.1182/Blood.V120.21.1329.1329 |
0.608 |
|
| 2012 |
Ellis MJ, Li D, Shen D, Luo J, Suman VJ, Wallis JW, Tine BAV, Hoog J, Crowder RJ, Snider JE, Ballman K, Chen K, Koboldt DC, Schierding WS, McMichael JF, ... ... Ley TJ, et al. Abstract LB-423: Whole genome comparisons of pre- and post- aromatase inhibitor treatment in estrogen receptor positive breast cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-423 |
0.418 |
|
| 2012 |
Gruber TA, Gedman AL, Ta H, Zhang J, Koss C, Marada S, Chen S, Su X, Ogden S, Gupta V, Andersson A, Pounds S, Shi L, Easton J, Wang J, ... ... Ley TJ, et al. Abstract 4867: Identification of an inv(16)-encodedCBFA2T3-GLIS2fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project Cancer Research. 72: 4867-4867. DOI: 10.1158/1538-7445.Am2012-4867 |
0.331 |
|
| 2011 |
Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, ... ... Ley TJ, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. Jama. 305: 1577-84. PMID 21505136 DOI: 10.1001/Jama.2011.497 |
0.751 |
|
| 2011 |
Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, ... ... Ley TJ, et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. Jama. 305: 1568-76. PMID 21505135 DOI: 10.1001/Jama.2011.473 |
0.768 |
|
| 2011 |
Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, ... ... Ley TJ, et al. Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. The Journal of Clinical Investigation. 121: 1445-55. PMID 21436584 DOI: 10.1172/Jci45284 |
0.79 |
|
| 2011 |
Walter MJ, Ding L, Shen D, Shao J, Grillot M, McLellan M, Fulton R, Schmidt H, Kalicki-Veizer J, O'Laughlin M, Kandoth C, Baty J, Westervelt P, Dipersio JF, Mardis ER, ... ... Ley TJ, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes Leukemia. 25: 1153-1158. PMID 21415852 DOI: 10.1182/Blood.V116.21.608.608 |
0.665 |
|
| 2011 |
Welch JS, Yuan W, Ley TJ. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. The Journal of Clinical Investigation. 121: 1636-45. PMID 21364283 DOI: 10.1172/Jci42953 |
0.384 |
|
| 2011 |
Welch JS, Klco JM, Varghese N, Nagarajan R, Ley TJ. Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice. Blood. 117: 2460-8. PMID 21190992 DOI: 10.1182/Blood-2010-08-300087 |
0.372 |
|
| 2011 |
Gruber TA, Gedman AL, Ta HQ, Zhang J, Koss C, Chen S, Su X, Gupta V, Ogden S, Andersson AK, Easton J, Wang J, Rusch M, Ding L, Cazzaniga G, ... ... Ley TJ, et al. Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project Blood. 118: 757-757. DOI: 10.1182/Blood.V118.21.757.757 |
0.453 |
|
| 2011 |
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen S, Collins-Underwood R, Ma J, Roberts KG, ... ... Ley TJ, et al. Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project Blood. 118: 68-68. DOI: 10.1182/Blood.V118.21.68.68 |
0.519 |
|
| 2011 |
Welch JS, Larson D, Ding L, McLellan MD, Lamprecht T, Kandoth C, Payton JE, Baty J, Harris CC, Lichti CF, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, ... ... Ley TJ, et al. Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes Blood. 118: 404-404. DOI: 10.1182/Blood.V118.21.404.404 |
0.785 |
|
| 2011 |
Grieselhuber NR, Klco JM, Verdoni AM, Ley TJ. Activation of Notch Signaling Is An Early Event in the Development of PML-Rara-Induced Acute Promyelocytic Leukemia (APL) Blood. 118: 2468-2468. DOI: 10.1182/Blood.V118.21.2468.2468 |
0.734 |
|
| 2011 |
Graubert T, Shen D, Ding L, Mardis E, Ley T, Wilson R, Walter M. 242 Genomics of myelodysplastic syndromes Leukemia Research. 35. DOI: 10.1016/S0145-2126(11)70244-2 |
0.556 |
|
| 2010 |
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, et al. DNMT3A mutations in acute myeloid leukemia. The New England Journal of Medicine. 363: 2424-33. PMID 21067377 DOI: 10.1056/Nejmoa1005143 |
0.776 |
|
| 2010 |
Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, ... Ley TJ, et al. Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Research. 20: 1590-604. PMID 20935160 DOI: 10.1101/Gr.107995.110 |
0.633 |
|
| 2010 |
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 116: 5316-26. PMID 20876853 DOI: 10.1182/Blood-2010-05-285395 |
0.673 |
|
| 2010 |
Uy GL, Lane AA, Welch JS, Grieselhuber NR, Payton JE, Ley TJ. A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia. Blood. 116: 3604-10. PMID 20647568 DOI: 10.1182/Blood-2008-11-189282 |
0.711 |
|
| 2010 |
Xiang Z, Luo H, Payton JE, Cain J, Ley TJ, Opferman JT, Tomasson MH. Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. The Journal of Clinical Investigation. 120: 2109-18. PMID 20484815 DOI: 10.1182/Blood.V114.22.764.764 |
0.428 |
|
| 2010 |
Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, ... ... Ley TJ, et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature. 464: 999-1005. PMID 20393555 DOI: 10.1038/Nature08989 |
0.398 |
|
| 2010 |
Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, ... ... Ley TJ, et al. International network of cancer genome projects. Nature. 464: 993-8. PMID 20393554 DOI: 10.1038/Nature08987 |
0.304 |
|
| 2010 |
Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA. POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia. 24: 950-7. PMID 20376082 DOI: 10.1038/Leu.2010.61 |
0.756 |
|
| 2010 |
Cai SF, Cao X, Hassan A, Fehniger TA, Ley TJ. Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. Blood. 115: 1669-77. PMID 19965675 DOI: 10.1182/Blood-2009-07-233676 |
0.574 |
|
| 2010 |
Ramsingh G, Koboldt D, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Characterization of the microRNAome in a patient with acute myeloid leukemia. Journal of Clinical Oncology. 28: 10501-10501. DOI: 10.1200/Jco.2010.28.15_Suppl.10501 |
0.653 |
|
| 2010 |
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch JS, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, et al. Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes Blood. 116: 99-99. DOI: 10.1182/Blood.V116.21.99.99 |
0.79 |
|
| 2010 |
Walter MJ, Shen D, Shao J, Ding L, Grillot M, McLellan M, Fulton R, Schmidt H, Kalicki-Veizer J, Michelle O, Westervelt P, DiPersio JF, Mardis ER, Wilson R, Ley TJ, et al. Recurrent DNMT3A Mutations In Patients with Myelodysplastic Syndrome Blood. 116: 608-608. DOI: 10.1182/blood.v116.21.608.608 |
0.381 |
|
| 2010 |
Schuettpelz L, Link DC, Shen D, Walter MJ, Koboldt DC, Dooling DJ, Fulton RS, Schmidt H, Maupin R, O'Laughlin M, Chen K, McLellan MD, Kulkarni S, Ivanovich J, Lebeau M, ... ... Ley TJ, et al. DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia Blood. 116: 580-580. DOI: 10.1182/Blood.V116.21.580.580 |
0.787 |
|
| 2010 |
Walter MJ, Shen D, Ding L, Shao J, Witowski S, Chen K, Koboldt DC, Dooling DJ, Maupin R, Fulton RS, Schmidt H, O'Laughlin M, McLellan MD, Frater J, Westervelt P, ... ... Ley TJ, et al. Detection of Novel Mutations In MDS/AML by Whole Genome Sequencing Blood. 116: 299-299. DOI: 10.1182/Blood.V116.21.299.299 |
0.677 |
|
| 2010 |
Welch JS, Ding L, Chen K, Larson DE, Kulkarni S, Payton JE, Wallis J, Veizer J, McLellan MD, Vickery TL, Reed JP, Koboldt DC, Klco J, DiPersio JF, Mardis ER, ... Ley TJ, et al. Resolution of a Clinical Dilemma with Whole Genome Sequencing, and Discovery of a New Mechanism for Generating PML-Rara: Insertional Fusion Blood. 116: 2755-2755. DOI: 10.1182/Blood.V116.21.2755.2755 |
0.408 |
|
| 2010 |
Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, ... Ley TJ, et al. The NK Cell MicroRNA Transcriptome Defined by Next-Generation Sequencing Identifies IL-15-Signaled Alterations In Mature MiR-223 Expression, and MiR-223 as a Potential Regulator of Murine Granzyme B Blood. 116: 104-104. DOI: 10.1182/Blood.V116.21.104.104 |
0.625 |
|
| 2010 |
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang L, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, et al. Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B12 |
0.659 |
|
| 2009 |
Walter MJ, Graubert TA, Dipersio JF, Mardis ER, Wilson RK, Ley TJ. Next-generation sequencing of cancer genomes: back to the future. Personalized Medicine. 6: 653. PMID 20161678 DOI: 10.2217/Pme.09.52 |
0.606 |
|
| 2009 |
Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Research. 69: 8700-9. PMID 19843867 DOI: 10.1158/0008-5472.Can-09-1145 |
0.553 |
|
| 2009 |
Chen K, Wallis JW, McLellan MD, Larson DE, Kalicki JM, Pohl CS, McGrath SD, Wendl MC, Zhang Q, Locke DP, Shi X, Fulton RS, Ley TJ, Wilson RK, Ding L, et al. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. Nature Methods. 6: 677-81. PMID 19668202 DOI: 10.1038/Nmeth.1363 |
0.325 |
|
| 2009 |
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, ... ... Ley TJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. The New England Journal of Medicine. 361: 1058-66. PMID 19657110 DOI: 10.1056/Nejmoa0903840 |
0.791 |
|
| 2009 |
Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrózek K, ... ... Ley TJ, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12950-5. PMID 19651600 DOI: 10.1073/Pnas.0903091106 |
0.75 |
|
| 2009 |
Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of Clinical Investigation. 119: 1714-26. PMID 19451695 DOI: 10.1172/Jci38248 |
0.802 |
|
| 2009 |
Cai SF, Fehniger TA, Cao X, Mayer JC, Brune JD, French AR, Ley TJ. Differential expression of granzyme B and C in murine cytotoxic lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 182: 6287-97. PMID 19414782 DOI: 10.4049/Jimmunol.0804333 |
0.575 |
|
| 2009 |
Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TJ, DiPersio JF. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood. 113: 6206-14. PMID 19050309 DOI: 10.1182/Blood-2008-06-162123 |
0.394 |
|
| 2009 |
Wartman LD, Ding L, Larson DE, McLellan MD, Schmidt H, Xiang Z, Tomasson M, Mardis E, Wilson RK, Ley TJ. DNA Sequencing of a Murine Acute Promyelocytic Leukemia (APL) Genome Using Next Generation Technology. Blood. 114: 3965-3965. DOI: 10.1182/Blood.V114.22.3965.3965 |
0.504 |
|
| 2009 |
White DW, Keppel CR, Schneider SE, Coder J, Reese TA, Payton JE, Ley TJ, Virgin HW, Fehniger TA. Latent Murine Herpesvirus-4 Infection Arms NK Cells. Blood. 114: 3678-3678. DOI: 10.1182/Blood.V114.22.3678.3678 |
0.32 |
|
| 2009 |
Kunter GM, Woloszynek J, Ley T, Link DC. Increased ROS Stress and Alterations in the Bone Marrow Microenvironment Contribute to DNA Damage in Hematopoietic Stem/Progenitors Carrying a Csf3r Truncation Mutation. Blood. 114: 3630-3630. DOI: 10.1182/Blood.V114.22.3630.3630 |
0.651 |
|
| 2009 |
Welch JS, Ley T. The Effect of Rara Haploinsufficiency in a Mouse Model of Acute Promyelocytic Leukemia. Blood. 114: 3475-3475. DOI: 10.1182/Blood.V114.22.3475.3475 |
0.351 |
|
| 2009 |
Ramsingh G, Koboldt DC, Fehniger TA, Wylie T, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia. Blood. 114: 271-271. DOI: 10.1182/Blood.V114.22.271.271 |
0.669 |
|
| 2009 |
Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA. POU4F1 Is Associated with t(8;21) AML and Contributes Directly to Its Unique Transcriptional Signature. Blood. 114: 2623-2623. DOI: 10.1182/Blood.V114.22.2623.2623 |
0.758 |
|
| 2009 |
Payton JE, Marcucci G, Radmacher MD, Maharry K, Langer C, Baldus CD, Bloomfield CD, Ley TJ. Multiplexed Digital Quantification of mRNA Abundance: a Highly Reproducible, PCR–independent Assessment of BAALC, ERG, and MN1 mRNA Levels in Acute Myeloid Leukemia (AML) Bone Marrow (BM) and Peripheral Blood (PB) Samples. Blood. 114: 1599-1599. DOI: 10.1182/Blood.V114.22.1599.1599 |
0.315 |
|
| 2009 |
Grieselhuber NR, Shaik JS, Chang L, McGrath S, Wartman LD, Nagarajan R, Wilson RK, Mardis E, Ley TJ. Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing. Blood. 114: 1276-1276. DOI: 10.1182/Blood.V114.22.1276.1276 |
0.725 |
|
| 2008 |
Fehniger TA, Nelson AD, Trinkaus K, Abboud CN, Cashen AF, DiPersio JF, Ley TJ, Uy GL, Westervelt P, Vij R. Preliminary results of a phase II study of high dose lenalidomide as initial therapy for acute myeloid leukemia in patients ≥ 60 years old. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 7058. PMID 27949623 DOI: 10.1200/Jco.2008.26.15_Suppl.7058 |
0.332 |
|
| 2008 |
Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 456: 66-72. PMID 18987736 DOI: 10.1038/Nature07485 |
0.79 |
|
| 2008 |
Funk RK, Maxwell TJ, Izumi M, Edwin D, Kreisel F, Ley TJ, Cheverud JM, Graubert TA. Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice. Blood. 112: 1434-42. PMID 18552208 DOI: 10.1182/Blood-2008-01-132084 |
0.593 |
|
| 2008 |
Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, McLeod HL, Ley TJ, Graubert TA. wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data. Nucleic Acids Research. 36: e41. PMID 18334530 DOI: 10.1093/Nar/Gkn110 |
0.715 |
|
| 2008 |
Chang LW, Payton JE, Yuan W, Ley TJ, Nagarajan R, Stormo GD. Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia. Genome Biology. 9: R38. PMID 18291030 DOI: 10.1186/Gb-2008-9-2-R38 |
0.33 |
|
| 2008 |
Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, ... ... Ley TJ, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 111: 4797-808. PMID 18270328 DOI: 10.1182/Blood-2007-09-113027 |
0.794 |
|
| 2008 |
Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, ... ... Ley TJ, et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 111: 4809-12. PMID 18160671 DOI: 10.1182/Blood-2007-05-090308 |
0.791 |
|
| 2008 |
Mardis E, Ley TJ, Wilson RK. Sequencing Acute Myeloid Leukemia Genomes with “Next Generation” Technologies. Blood. 112: sci-36-sci-36. DOI: 10.1182/Blood.V112.11.Sci-36.Sci-36 |
0.464 |
|
| 2008 |
Welch JS, Yuan W, Ley TJ. Expression of PML-RARα by the Murine PML Locus Leads to Myeloid Self-Renewal, Clonal Expansion and Morphologic Promyelocytic Leukemia. Blood. 112: 932-932. DOI: 10.1182/Blood.V112.11.932.932 |
0.386 |
|
| 2008 |
Cao X, Collins LI, Cai SF, Mayer JC, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. IL-12 Stimulates Interferon-Gamma Mediated Inhibition of Tumor-Induced Regulatory T Cell Proliferation and Enhances Tumor Clearance Blood. 112: 2558-2558. DOI: 10.1182/Blood.V112.11.2558.2558 |
0.565 |
|
| 2007 |
Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 27: 635-46. PMID 17919943 DOI: 10.1016/J.Immuni.2007.08.014 |
0.58 |
|
| 2007 |
Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, Ley TJ. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity. 26: 798-811. PMID 17540585 DOI: 10.1016/J.Immuni.2007.04.010 |
0.786 |
|
| 2007 |
Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, ... ... Ley TJ, et al. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood. 110: 1648-55. PMID 17494858 DOI: 10.1182/Blood-2007-03-081216 |
0.786 |
|
| 2007 |
Graubert TA, Cahan P, Edwin D, Selzer RR, Richmond TA, Eis PS, Shannon WD, Li X, McLeod HL, Cheverud JM, Ley TJ. A high-resolution map of segmental DNA copy number variation in the mouse genome. Plos Genetics. 3: e3. PMID 17206864 DOI: 10.1371/Journal.Pgen.0030003 |
0.724 |
|
| 2007 |
Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ. Commonly dysregulated genes in murine APL cells. Blood. 109: 961-70. PMID 17008535 DOI: 10.1182/Blood-2006-07-036640 |
0.675 |
|
| 2007 |
Walter MJ, Ries RE, Armstrong JR, Park JS, Mardis ER, Ley TJ. Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2. Blood. 109: 1237-40. PMID 17008533 DOI: 10.1182/Blood-2006-07-037465 |
0.326 |
|
| 2007 |
Fehniger TA, Nelson A, Trinkaus K, Abboud CN, Cashen AF, DiPersio JF, Graubert TA, Ley TJ, Tomasson MH, Uy GL, Walter MJ, Westervelt P, Vij R. Phase II Study of High Dose Lenalidomide as Initial Treatment for Older Acute Myeloid Leukemia Patients: Early Results Show a Significant Reduction of Bone Marrow Blasts after 14 Days of Therapy. Blood. 110: 916-916. DOI: 10.1182/Blood.V110.11.916.916 |
0.567 |
|
| 2007 |
Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner T, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, ... ... Ley TJ, et al. Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia. Blood. 110: 823-823. DOI: 10.1182/Blood.V110.11.823.823 |
0.791 |
|
| 2007 |
Payton JE, Grieselhuber NR, Chang L, Murakami MA, Yuan W, Link DC, Nagarajan R, Watson MA, Ley TJ. The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes. Blood. 110: 719-719. DOI: 10.1182/Blood.V110.11.719.719 |
0.801 |
|
| 2007 |
Cai SF, Fehniger TA, Dai X, Cao X, Ley TJ. Differential Regulation of Granzyme B and C Expression in Murine Cytotoxic T and NK Cells. Blood. 110: 2291-2291. DOI: 10.1182/Blood.V110.11.2291.2291 |
0.577 |
|
| 2007 |
Ley TJ, DiPersio J, Ding L, Ries R, Magrini V, Payton J, McGrath S, Walter M, Wylie T, Dunford-Shore B, Chen K, McLellan M, Wendl M, Dooling D, Cook L, et al. Sequencing an Acute Myeloid Leukemia (AML) Genome with “Next Generation” Technologies. Blood. 110: 205-205. DOI: 10.1182/Blood.V110.11.205.205 |
0.78 |
|
| 2007 |
Walgren R, McLaughlin E, Peterson E, Crosswhite M, Province M, McLeod H, Ley T, Graubert T, Morgan G. Identification of Polymorphisms Associated with Susceptibility to Therapy-Related MDS and AML. Blood. 110: 15-15. DOI: 10.1182/Blood.V110.11.15.15 |
0.516 |
|
| 2007 |
Funk RK, Maxwell T, Izumi M, Edwin D, Kreisel F, Cheverud J, Ley TJ, Graubert T. Genetic Susceptibility to Therapy-Related Acute Murine Promyelocytic Leukemia. Blood. 110: 14-14. DOI: 10.1182/Blood.V110.11.14.14 |
0.611 |
|
| 2007 |
Walter MJ, Ries R, Li X, Shannon W, Payton J, Books J, Bloomfield C, Mrozek K, Ruppert A, DiPersio J, Link D, Tomasson M, Graubert T, Westervelt P, Watson M, ... ... Ley T, et al. High Resolution Array-Based CGH and SNP Studies of AML Genomes. Blood. 110: 107-107. DOI: 10.1182/Blood.V110.11.107.107 |
0.748 |
|
| 2006 |
Bredemeyer AJ, Carrigan PE, Fehniger TA, Smith DF, Ley TJ. Hop cleavage and function in granzyme B-induced apoptosis. The Journal of Biological Chemistry. 281: 37130-41. PMID 17005566 DOI: 10.1074/Jbc.M607969200 |
0.731 |
|
| 2006 |
Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood. 108: 1708-15. PMID 16675706 DOI: 10.1182/Blood-2006-04-015040 |
0.337 |
|
| 2006 |
Fehniger TA, Cai SF, Cao X, Bredemeyer AJ, Presti RM, French AR, Ley TJ. Murine NK Cells Require Activation-Dependent Expression of Granzyme B and Perforin To Become Potent Cytotoxic Effectors. Blood. 108: 920-920. DOI: 10.1182/Blood.V108.11.920.920 |
0.785 |
|
| 2006 |
Nervi B, Ramirez P, Holt M, Rettig MP, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TJ, DiPersio JF. CXCR4/SDF-1 Is a Key Regulator for Leukemia Migration and Homing to the BM: Impact of AMD3100 on In Vivo Response to Chemotherapy. Blood. 108: 569-569. DOI: 10.1182/Blood.V108.11.569.569 |
0.365 |
|
| 2006 |
Uy GL, Payton JE, Ley TJ. Multilineage Expansion of Lymphoid and Myeloid Cells in Mice Expressing PML-RARα under the Control of the Murine Cathepsin G Locus. Blood. 108: 2551-2551. DOI: 10.1182/Blood.V108.11.2551.2551 |
0.387 |
|
| 2006 |
Cao X, Cai SF, Fehniger TA, Song J, Piwnica-Worms D, Ley TJ. Granzyme B Is Important for Treg-Mediated Suppression of NK-Dependent Tumor Clearance In Vivo. Blood. 108: 133-133. DOI: 10.1182/Blood.V108.11.133.133 |
0.576 |
|
| 2005 |
Walter MJ, Park JS, Ries RE, Lau SK, McLellan M, Jaeger S, Wilson RK, Mardis ER, Ley TJ. Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha. Proceedings of the National Academy of Sciences of the United States of America. 102: 12513-8. PMID 16113082 DOI: 10.1073/Pnas.0504247102 |
0.389 |
|
| 2005 |
Bredemeyer AJ, Townsend RR, Ley TJ. Use of protease proteomics to discover granzyme B substrates. Immunologic Research. 32: 143-53. PMID 16106065 DOI: 10.1385/Ir:32:1-3:143 |
0.721 |
|
| 2005 |
Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. Journal of Immunology (Baltimore, Md. : 1950). 174: 2124-31. PMID 15699143 DOI: 10.4049/Jimmunol.174.4.2124 |
0.625 |
|
| 2005 |
Lane AA, Ley TJ. Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells. Molecular and Cellular Biology. 25: 23-33. PMID 15601827 DOI: 10.1128/Mcb.25.1.23-33.2005 |
0.357 |
|
| 2005 |
Yuan W, Grieselhuber NR, Green RD, Ley TJ. Identification of PML-RARa Target Genes Using Microarray and ChIP-on-Chip Analysis. Blood. 106: 2994-2994. DOI: 10.1182/Blood.V106.11.2994.2994 |
0.737 |
|
| 2005 |
Yuan W, Ley TJ. Transcriptome Analysis of Murine Myeloid Development. Blood. 106: 2724-2724. DOI: 10.1182/Blood.V106.11.2724.2724 |
0.385 |
|
| 2005 |
Nervi B, Holt M, Rettig MP, Bridger G, Ley TJ, DiPersio JF. AMD3100 Mobilizes Acute Promyelocytic Leukemia Cells from the Bone Marrow into the Peripheral Blood and Sensitizes Leukemia Cells to Chemotherapy. Blood. 106: 246-246. DOI: 10.1182/Blood.V106.11.246.246 |
0.392 |
|
| 2005 |
Walter MJ, Ries RR, Li XD, Shannon WJ, Payton J, Bloomfield CD, Mrozek K, Ruppert AS, DiPersio J, Link D, Tomasson M, Graubert T, McLeod H, Devine S, Watson M, ... ... Ley TJ, et al. Detection of Microdeletions and Amplifications in Primary Human Acute Myeloid Leukemia (AML) Genomes Using Ultradense Oligomer Tiling Path Arrays and Comparative Genomic Hybridization (CGH). Blood. 106: 2350-2350. DOI: 10.1182/Blood.V106.11.2350.2350 |
0.739 |
|
| 2004 |
Pham CT, Ivanovich JL, Raptis SZ, Zehnbauer B, Ley TJ. Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans. Journal of Immunology (Baltimore, Md. : 1950). 173: 7277-81. PMID 15585850 DOI: 10.4049/Jimmunol.173.12.7277 |
0.369 |
|
| 2004 |
Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ. Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures. Molecular and Cellular Biology. 24: 10882-93. PMID 15572690 DOI: 10.1128/Mcb.24.24.10882-10893.2004 |
0.447 |
|
| 2004 |
Loh J, Thomas DA, Revell PA, Ley TJ, Virgin HW. Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency. Journal of Virology. 78: 12519-28. PMID 15507639 DOI: 10.1128/Jvi.78.22.12519-12528.2004 |
0.538 |
|
| 2004 |
Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 21: 589-601. PMID 15485635 DOI: 10.1016/J.Immuni.2004.09.002 |
0.343 |
|
| 2004 |
Bredemeyer AJ, Lewis RM, Malone JP, Davis AE, Gross J, Townsend RR, Ley TJ. A proteomic approach for the discovery of protease substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 11785-90. PMID 15280543 DOI: 10.1073/Pnas.0402353101 |
0.709 |
|
| 2004 |
Lane AA, Ley TJ. Neutrophil Elastase Is Important for Several Activities of PML-RARα in Early Myeloid Cells. Blood. 104: 486-486. DOI: 10.1182/Blood.V104.11.486.486 |
0.409 |
|
| 2004 |
Cao X, Revell PA, Grossman WJ, Thomas DA, Lu ZH, Ley TJ. Orphan Granzymes Downstream from Granzyme B Are Important for Tumor Clearance In Vivo and in Vitro. Blood. 104: 2653-2653. DOI: 10.1182/blood.v104.11.2653.2653 |
0.546 |
|
| 2004 |
Lu ZH, Books JT, Ley TJ. The Cold-Shock Domain Protein YB-1 Is Important for Cellular Proliferation and the Prevention of Premature Senescence. Blood. 104: 2571-2571. DOI: 10.1182/Blood.V104.11.2571.2571 |
0.359 |
|
| 2004 |
Walter MJ, Ries RE, Armstrong J, O’Gara B, Vardiman JW, Caligiuri MA, Bloomfield CD, Hodgson G, Gray JW, Wilson RK, Mardis ER, Ley TJ. Genomic DNA Copy Number Alterations Present in AML Bone Marrow Samples with Normal Cytogenetics. Blood. 104: 142-142. DOI: 10.1182/Blood.V104.11.142.142 |
0.372 |
|
| 2003 |
Wilson RK, Ley TJ, Cole FS, Milbrandt JD, Clifton S, Fulton L, Fewell G, Minx P, Sun H, McLellan M, Pohl C, Mardis ER. Mutational profiling in the human genome. Cold Spring Harbor Symposia On Quantitative Biology. 68: 23-9. PMID 15338599 DOI: 10.1101/Sqb.2003.68.23 |
0.388 |
|
| 2003 |
Lane AA, Ley TJ. Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice. Cell. 115: 305-18. PMID 14636558 DOI: 10.1016/S0092-8674(03)00852-3 |
0.364 |
|
| 2003 |
Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, et al. A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 14275-80. PMID 14614138 DOI: 10.1073/Pnas.2335924100 |
0.792 |
|
| 2003 |
Grossman WJ, Revell PA, Lu ZH, Johnson H, Bredemeyer AJ, Ley TJ. The orphan granzymes of humans and mice. Current Opinion in Immunology. 15: 544-52. PMID 14499263 DOI: 10.1016/S0952-7915(03)00099-2 |
0.775 |
|
| 2003 |
Westervelt P, Lane AA, Pollock JL, Oldfather K, Holt MS, Zimonjic DB, Popescu NC, DiPersio JF, Ley TJ. High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 102: 1857-65. PMID 12750176 DOI: 10.1182/Blood-2002-12-3779 |
0.388 |
|
| 2003 |
Lu ZH, Books JT, Kaufman RM, Ley TJ. Long targeting arms do not increase the efficiency of homologous recombination in the beta-globin locus of murine embryonic stem cells. Blood. 102: 1531-3. PMID 12730107 DOI: 10.1182/Blood-2003-03-0708 |
0.321 |
|
| 2003 |
Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ. Cell death induced by granzyme C. Blood. 101: 3093-101. PMID 12515723 DOI: 10.1182/Blood-2002-08-2485 |
0.642 |
|
| 2002 |
Westervelt P, Pollock JL, Oldfather KM, Walter MJ, Ma MK, Williams A, DiPersio JF, Ley TJ. Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 99: 9468-73. PMID 12077315 DOI: 10.1073/Pnas.132657799 |
0.358 |
|
| 2002 |
Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proceedings of the National Academy of Sciences of the United States of America. 99: 8283-8. PMID 12060771 DOI: 10.1073/Pnas.122233699 |
0.461 |
|
| 2002 |
Russell JH, Ley TJ. Lymphocyte-mediated cytotoxicity. Annual Review of Immunology. 20: 323-70. PMID 11861606 DOI: 10.1146/Annurev.Immunol.20.100201.131730 |
0.324 |
|
| 2001 |
Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proceedings of the National Academy of Sciences of the United States of America. 98: 14985-90. PMID 11752447 DOI: 10.1073/Pnas.261581498 |
0.655 |
|
| 2001 |
Pollock JL, Westervelt P, Walter MJ, Lane AA, Ley TJ. Mouse models of acute promyelocytic leukemia Current Opinion in Hematology. 8: 206-211. PMID 11561157 DOI: 10.1097/00062752-200107000-00005 |
0.354 |
|
| 2001 |
Kaufman RM, Lu ZH, Behl R, Holt JM, Ackers GK, Ley TJ. Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine β-major and β-minor globin genes Blood. 98: 65-73. PMID 11418464 DOI: 10.1182/Blood.V98.1.65 |
0.306 |
|
| 2000 |
Zimonjic DB, Pollock JL, Westervelt P, Popescu NC, Ley TJ. Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 97: 13306-13311. PMID 11087871 DOI: 10.1073/Pnas.97.24.13306 |
0.357 |
|
| 2000 |
Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 12: 621-32. PMID 10894162 DOI: 10.1016/S1074-7613(00)80213-7 |
0.539 |
|
| 2000 |
Bender MA, Mehaffey MG, Telling A, Hug B, Ley TJ, Groudine M, Fiering S. Independent formation of DnaseI hypersensitive sites in the murine β-globin locus control region Blood. 95: 3600-3604. DOI: 10.1182/Blood.V95.11.3600.011K42_3600_3604 |
0.308 |
|
| 1999 |
Pollock JL, Westervelt P, Kurichety AK, Pelicci PG, Grisolano JL, Ley TJ. A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα- driven acute promyelocytic leukemia Proceedings of the National Academy of Sciences of the United States of America. 96: 15103-15108. PMID 10611345 DOI: 10.1073/Pnas.96.26.15103 |
0.343 |
|
| 1999 |
MacIvor DM, Shapiro SD, Pham CTN, Belaaouaj A, Abraham SN, Ley TJ. Normal neutrophil function in cathepsin G-deficient mice Blood. 94: 4282-4293. PMID 10590073 DOI: 10.1182/Blood.V94.12.4282.424K45_4282_4293 |
0.314 |
|
| 1999 |
Pham CTN, Ley TJ. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo Proceedings of the National Academy of Sciences of the United States of America. 96: 8627-8632. PMID 10411926 DOI: 10.1073/Pnas.96.15.8627 |
0.308 |
|
| 1999 |
Shresta S, Graubert TA, Thomas DA, Raptis SZ, Ley TJ. Granzyme A initiates an alternative pathway for granule-mediated apoptosis. Immunity. 10: 595-605. PMID 10367905 DOI: 10.1016/S1074-7613(00)80059-X |
0.695 |
|
| 1999 |
Westervelt P, Ley TJ. Seed versus soil: The importance of the target cell for transgenic models of human leukemias Blood. 93: 2143-2148. PMID 10090920 DOI: 10.1182/Blood.V93.7.2143 |
0.361 |
|
| 1999 |
MacIvor DM, Pham CTN, Ley TJ. The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice Blood. 93: 963-973. PMID 9920846 DOI: 10.1182/Blood.V93.3.963 |
0.38 |
|
| 1998 |
Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ. How do cytotoxic lymphocytes kill their targets? Current Opinion in Immunology. 10: 581-7. PMID 9794837 DOI: 10.1016/S0952-7915(98)80227-6 |
0.684 |
|
| 1998 |
Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ. Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene Nucleic Acids Research. 26: 2849-2858. PMID 9611227 DOI: 10.1093/Nar/26.12.2849 |
0.579 |
|
| 1998 |
Pham CT, Thomas DA, Mercer JD, Ley TJ. Production of fully active recombinant murine granzyme B in yeast. The Journal of Biological Chemistry. 273: 1629-33. PMID 9430705 DOI: 10.1074/Jbc.273.3.1629 |
0.538 |
|
| 1997 |
Graubert TA, DiPersio JF, Russell JH, Ley TJ. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation Journal of Clinical Investigation. 100: 904-911. PMID 9259590 DOI: 10.1172/Jci119606 |
0.583 |
|
| 1997 |
Shresta S, Goda P, Wesselschmidt R, Ley TJ. Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. The Journal of Biological Chemistry. 272: 20236-44. PMID 9242702 DOI: 10.1074/Jbc.272.32.20236 |
0.348 |
|
| 1997 |
Pham CTN, Ley TJ. The role of granzyme B cluster proteases in cell-mediated cytotoxicity Seminars in Immunology. 9: 127-133. PMID 9194223 DOI: 10.1006/Smim.1997.0060 |
0.361 |
|
| 1997 |
Grisolano JL, Wesselschmidt RL, Pelicci PG, Ley TJ. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARα under control of cathepsin G regulatory sequences Blood. 89: 376-387. PMID 9002938 DOI: 10.1182/Blood.V89.2.376 |
0.401 |
|
| 1996 |
Graubert TA, Ley TJ. How do lymphocytes kill tumor cells? Clinical Cancer Research. 2: 785-789. PMID 9816231 |
0.504 |
|
| 1996 |
Grisolano JL, Ley TJ. Regulation of azurophil granule-associated serine protease genes during myelopoiesis Current Opinion in Hematology. 3: 55-62. PMID 9372052 DOI: 10.1097/00062752-199603010-00009 |
0.314 |
|
| 1996 |
Pham CTN, Macivor DM, Hug BA, Heusel JW, Ley TJ. Long-range disruption of gene expression by a selectable marker cassette Proceedings of the National Academy of Sciences of the United States of America. 93: 13090-13095. PMID 8917549 DOI: 10.1073/Pnas.93.23.13090 |
0.358 |
|
| 1996 |
Darmon AJ, Ley TJ, Nicholson DW, Bleackley RC. Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation. The Journal of Biological Chemistry. 271: 21709-12. PMID 8702964 DOI: 10.1074/Jbc.271.36.21709 |
0.325 |
|
| 1996 |
Graubert TA, Russell JH, Ley TJ. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection Blood. 87: 1232-1237. PMID 8608209 DOI: 10.1182/Blood.V87.4.1232.Bloodjournal8741232 |
0.576 |
|
| 1995 |
Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I Proceedings of the National Academy of Sciences of the United States of America. 92: 1057-1061. PMID 7862633 DOI: 10.1073/Pnas.92.4.1057 |
0.351 |
|
| 1995 |
Shresta S, MacIvor DM, Heusel JW, Russell JH, Ley TJ. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 5679-83. PMID 7777569 DOI: 10.1073/Pnas.92.12.5679 |
0.334 |
|
| 1995 |
Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DIK, Enver T, Ley TJ, Groudine M. Targeted deletion of 5′HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus Genes and Development. 9: 2203-2213. PMID 7557375 DOI: 10.1101/Gad.9.18.2203 |
0.393 |
|
| 1995 |
Shresta S, Heusel JW, Macivor DM, Wesselschmidt RL, Russell JH, Ley TJ. Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis. Immunological Reviews. 146: 211-21. PMID 7493755 DOI: 10.1111/J.1600-065X.1995.Tb00690.X |
0.321 |
|
| 1994 |
Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell. 76: 977-87. PMID 8137431 DOI: 10.1016/0092-8674(94)90376-X |
0.354 |
|
| 1994 |
Grisolano JL, Sclar GM, Ley TJ. Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 8989-93. PMID 8090757 DOI: 10.1073/Pnas.91.19.8989 |
0.387 |
|
| 1993 |
Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ. The Human Mast Cell Chymase Gene (CMA1): Mapping to the Cathepsin G/Granzyme Gene Cluster and Lineage-Restricted Expression Genomics. 15: 614-620. PMID 8468056 DOI: 10.1006/Geno.1993.1115 |
0.343 |
|
| 1993 |
Heusel JW, Scarpati EM, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro SD, Ley TJ. Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. Blood. 81: 1614-23. PMID 8453108 DOI: 10.1182/Blood.V81.6.1614.1614 |
0.35 |
|
| 1993 |
Hanson RD, Grisolano JL, Ley TJ. Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription Blood. 82: 2749-2757. PMID 8219227 DOI: 10.1182/Blood.V82.9.2749.Bloodjournal8292749 |
0.322 |
|
| 1992 |
Hanson RD, Ley TJ. A-T-rich scaffold attachment regions flank the hematopoietic serine protease genes clustered on chromosome 14q11.2 Blood. 79: 610-618. PMID 1732006 DOI: 10.1182/Blood.V79.3.610.610 |
0.354 |
|
| 1992 |
Hug BA, Moon AM, Ley TJ. Structure and function of the murine β-globin locus control region 5′ HS-3 Nucleic Acids Research. 20: 5771-5778. PMID 1454538 DOI: 10.1093/Nar/20.21.5771 |
0.337 |
|
| 1992 |
Link DC, Gutkind SJ, Robbins KC, Ley TJ. Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter Oncogene. 7: 877-884. PMID 1373875 |
0.608 |
|
| 1991 |
Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes Molecular and Cellular Biology. 11: 1500-1507. PMID 1847500 DOI: 10.1128/Mcb.11.3.1500 |
0.671 |
|
| 1991 |
Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL. 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression Journal of Leukocyte Biology. 50: 427-433. PMID 1660912 DOI: 10.1002/Jlb.50.5.427 |
0.624 |
|
| 1990 |
Hanson RD, Hohn PA, Popescu NC, Ley TJ. A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human α/δ T-cell receptor locus Proceedings of the National Academy of Sciences of the United States of America. 87: 960-963. PMID 2300587 DOI: 10.1073/Pnas.87.3.960 |
0.344 |
|
| 1990 |
Ulrich MJ, Moon AM, Ley TJ. Function of transfected globin promoters and the globin locus activator in K562 erythroleukemia cells Annals of the New York Academy of Sciences. 612: 207-214. PMID 2291547 DOI: 10.1111/J.1749-6632.1990.Tb24308.X |
0.306 |
|
| 1990 |
Hanson RD, Ley TJ. Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes Molecular and Cellular Biology. 10: 5655-5662. PMID 2233710 DOI: 10.1128/Mcb.10.11.5655 |
0.328 |
|
| 1990 |
Moon AM, Ley TJ. Conservation of the primary structure, organization, and function of the human and mouse β-globin locus-activating regions Proceedings of the National Academy of Sciences of the United States of America. 87: 7693-7697. PMID 2217202 DOI: 10.1073/Pnas.87.19.7693 |
0.326 |
|
| 1990 |
Ulrich M, Ley T. Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells. Blood. 75: 990-999. DOI: 10.1182/Blood.V75.4.990.Bloodjournal754990 |
0.351 |
|
| 1989 |
Ley TJ, Connolly NL, Katamine S, Cheah MS, Senior RM, Robbins KC. Tissue-specific expression and developmental regulation of the human fgr proto-oncogene. Molecular and Cellular Biology. 9: 92-9. PMID 2538725 DOI: 10.1128/Mcb.9.1.92 |
0.314 |
|
| 1988 |
Gimble J, Max E, Ley T. High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin. Blood. 72: 606-612. DOI: 10.1182/Blood.V72.2.606.606 |
0.34 |
|
| 1987 |
Bodine DM, Ley TJ. An enhancer element lies 3' to the human A gamma globin gene Embo Journal. 6: 2997-3004. PMID 3691478 DOI: 10.1002/J.1460-2075.1987.Tb02605.X |
0.336 |
|
| 1986 |
Cheah MSC, Ley TJ, Tronick SR, Robbins KC. fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection Nature. 319: 238-240. PMID 3003578 DOI: 10.1038/319238A0 |
0.33 |
|
| 1985 |
Humphries RK, Dover G, Young NS, Moore JG, Charache S, Ley T, Nienhuis AW. 5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin Journal of Clinical Investigation. 75: 547-557. PMID 2579100 DOI: 10.1172/Jci111731 |
0.32 |
|
| 1984 |
Chiang YL, Ley TJ, Sanders-Haigh L, Anderson WF. Human globin gene expression in hybrid 2S MEL X human fibroblast cells. Somatic Cell and Molecular Genetics. 10: 399-407. PMID 6589792 DOI: 10.1007/Bf01535635 |
0.323 |
|
| 1984 |
Ley TJ, Chiang YL, Haidaris D, Anagnou NP, Wilson VL, Anderson WF. DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proceedings of the National Academy of Sciences of the United States of America. 81: 6618-22. PMID 6208553 DOI: 10.1073/Pnas.81.21.6618 |
0.334 |
|
| 1983 |
Goldsmith ME, Humphries RK, Ley T, Cline A, Kantor JA, Nienhuis AW. "Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. Proceedings of the National Academy of Sciences of the United States of America. 80: 2318-22. PMID 6572978 DOI: 10.1073/Pnas.80.8.2318 |
0.316 |
|
| 1983 |
Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN. Inducible transcription of five globin genes in K562 human leukemia cells Proceedings of the National Academy of Sciences of the United States of America. 80: 5515-5519. PMID 6310580 DOI: 10.1073/Pnas.80.18.5515 |
0.311 |
|
| 1983 |
Anagnou NP, Ley TJ, Chesbro B, Wright G, Kitchens C, Liebhaber S, Nienhuis AW, Deisseroth AB. Acquired α-thalassemia in preleukemia is due to decreased expression of all four α-globin genes Proceedings of the National Academy of Sciences of the United States of America. 80: 6051-6055. PMID 6136971 DOI: 10.1073/Pnas.80.19.6051 |
0.306 |
|
| 1983 |
Ley T, DeSimone J, Noguchi C, Turner P, Schechter A, Heller P, Nienhuis A. 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia Blood. 62: 370-380. DOI: 10.1182/Blood.V62.2.370.Bloodjournal622370 |
0.334 |
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| 1982 |
Ley TJ, Anagnou NP, Pepe G, Nienhuis AW. RNA processing errors in patients with beta-thalassemia Proceedings of the National Academy of Sciences of the United States of America. 79: 4775-4779. PMID 6956887 DOI: 10.1073/Pnas.79.15.4775 |
0.331 |
|
| 1982 |
Ley TJ, DeSimone J, Anagnou NP, Keller GH, Humphries RK, Turner PH, Young NS, Keller P, Nienhuis AW. 5-Azacytidine selectively increases γ-globin synthesis in a patient with β + thalassemia New England Journal of Medicine. 307: 1469-1475. PMID 6183586 DOI: 10.1056/Nejm198212093072401 |
0.311 |
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