Gordon L. Amidon - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacy, Biochemistry
Website:
https://pharmacy.umich.edu/people/glamidon

312 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yu A, Koenigsknecht MJ, Hens B, Baker JR, Wen B, Jackson TL, Pai MP, Hasler W, Amidon GL, Sun D. Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution. The Aaps Journal. 22: 3. PMID 31712917 DOI: 10.1208/s12248-019-0385-z  0.64
2019 Al-Gousous J, Salehi N, Amidon GE, Ziff RM, Langguth P, Amidon GL. Mass transport analysis of bicarbonate buffer: Effect of the CO-HCO hydration-dehydration kinetics in the fluid boundary layer and the apparent effective pKa controlling dissolution of acids and bases. Molecular Pharmaceutics. PMID 31013101 DOI: 10.1021/acs.molpharmaceut.9b00187  0.56
2019 Bermejo M, Kuminek G, Al-Gousous J, Ruiz-Picazo A, Tsume Y, Garcia-Arieta A, González-Alvarez I, Hens B, Amidon GE, Rodriguez-Hornedo N, Amidon GL, Mudie D. Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses. Pharmaceutics. 11. PMID 30884755 DOI: 10.3390/pharmaceutics11030122  1
2019 Baker JR, Dickens JR, Koenigsknecht M, Frances A, Lee AA, Shedden KA, Brasseur JG, Amidon GL, Sun D, Hasler WL. Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors. Journal of Neurogastroenterology and Motility. 25: 100-112. PMID 30646481 DOI: 10.5056/jnm18112  0.64
2018 Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State. Molecular Pharmaceutics. PMID 30417648 DOI: 10.1021/acs.molpharmaceut.8b00736  1
2018 Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden KA, Wen B, Wysocki J, Löbenberg R, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State. Molecular Pharmaceutics. PMID 30372084 DOI: 10.1021/acs.molpharmaceut.8b00515  1
2018 Al-Gousous J, Sun KX, McNamara DP, Hens B, Salehi N, Langguth P, Bermejo M, Amidon GE, Amidon GL. Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance. Molecular Pharmaceutics. PMID 30362350 DOI: 10.1021/acs.molpharmaceut.8b00783  0.56
2018 Tsume Y, Patel S, Fotaki N, Bergstrӧm C, Amidon GL, Brasseur JG, Mudie DM, Sun D, Bermejo M, Gao P, Zhu W, Sperry DC, Vertzoni M, Parrott N, Lionberger R, ... ... Amidon GE, et al. In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance. The Aaps Journal. 20: 100. PMID 30191341 DOI: 10.1208/s12248-018-0260-3  1
2018 Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu HJ, Amidon GL, Smith DE. Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice. Biochemical Pharmacology. PMID 30121252 DOI: 10.1016/j.bcp.2018.08.018  1
2018 Hens B, Sinko P, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, ... ... Amidon GE, ... ... Amidon GL, et al. Formulation Predictive Dissolution (fPD) Testing to Advance Oral Drug Product Development: an Introduction to the US FDA Funded '21 Century BA/BE' Project. International Journal of Pharmaceutics. PMID 29944899 DOI: 10.1016/j.ijpharm.2018.06.050  1
2018 Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Gastric Emptying and Intestinal Appearance of Nonabsorbable Drugs Phenol Red and Paromomycin in Human Subjects: A Multi-Compartment Stomach Approach. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 29857136 DOI: 10.1016/j.ejpb.2018.05.033  1
2018 Hens B, Talattof A, Paixão P, Bermejo M, Tsume Y, Löbenberg R, Amidon GL. Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model. The Aaps Journal. 20: 57. PMID 29600330 DOI: 10.1208/s12248-018-0217-6  1
2018 Talattof A, Amidon GL. Pulse Packet Stochastic Model for Gastric Emptying in the Fasted State: A Physiological Approach. Molecular Pharmaceutics. PMID 29504768 DOI: 10.1021/acs.molpharmaceut.7b01077  0.8
2018 Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, Amidon GE, Cavanagh K, Kuminek G, Benninghoff G, Fan J, Rodríguez-Hornedo N, Amidon GL. Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29378253 DOI: 10.1016/j.ejps.2018.01.039  1
2017 Sun K, Xu H, Hilfinger JL, Lee KD, Provoda CJ, Sabit H, Amidon GL. Improved Protease-Targeting and Biopharmaceutical Properties of Novel Prodrugs of Ganciclovir. Molecular Pharmaceutics. PMID 29251944 DOI: 10.1021/acs.molpharmaceut.7b00792  0.8
2017 Yu A, Jackson T, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D. Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time. The Aaps Journal. PMID 28980204 DOI: 10.1208/s12248-017-0145-x  1
2017 Sun D, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai M, Bleske B, Zhang X, Lionberger R, Lee A, Amidon G, Hasler WL, et al. In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract Under Fed and Fasted Conditions. Molecular Pharmaceutics. PMID 28937221 DOI: 10.1021/acs.molpharmaceut.7b00425  1
2017 Tsume Y, Igawa N, Drelich AJ, Amidon GE, Amidon GL. The combination of GIS and biphasic to better predict in vivo dissolution of BCS class IIb drugs, ketoconazole and raloxifene. Journal of Pharmaceutical Sciences. PMID 28919384 DOI: 10.1016/j.xphs.2017.09.002  1
2017 Tsume Y, Drelich AJ, Smith DE, Amidon GL. Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine. Molecules (Basel, Switzerland). 22. PMID 28796151 DOI: 10.3390/molecules22081322  1
2017 Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht M, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden KA, Wen B, Wysocki J, Löbenberg R, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Low Buffer Capacity and Alternating Motility Along The Human Gastrointestinal Tract: Implications for In Vivo Dissolution and Absorption of Ionizable Drugs. Molecular Pharmaceutics. PMID 28737409 DOI: 10.1021/acs.molpharmaceut.7b00426  1
2017 Murray K, Hoad CL, Mudie DM, Wright J, Heissam K, Abrehart N, Pritchard SE, Al Atwah S, Gowland PA, Garnett MC, Amidon GE, Spiller RC, Amidon GL, Marciani L. Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans. Molecular Pharmaceutics. PMID 28648070 DOI: 10.1021/acs.molpharmaceut.7b00095  0.56
2017 Tsume Y, Matsui K, Searls AL, Takeuchi S, Amidon GE, Sun D, Amidon GL. The impact of supersaturation level for oral absorption of BCS class IIb drugs, dipyridamole and ketoconazole, using in vivo predictive dissolution system: Gastrointestinal Simulator (GIS). European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28263914 DOI: 10.1016/j.ejps.2017.02.042  1
2017 Matsui K, Tsume Y, Takeuchi S, Searls A, Amidon GL. Utilization of Gastrointestinal Simulator (GIS), an in vivo predictive dissolution methodology, coupled with computational approach to forecast oral absorption of dipyridamole. Molecular Pharmaceutics. PMID 28231003 DOI: 10.1021/acs.molpharmaceut.6b01063  1
2016 Yu A, Baker JR, Fioritto AF, Wang Y, Luo R, Li S, Wen B, Bly M, Tsume Y, Koenigsknecht MJ, Zhang X, Lionberger R, Amidon GL, Hasler WL, Sun D. Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract. Molecular Pharmaceutics. PMID 28009518 DOI: 10.1021/acs.molpharmaceut.6b00641  1
2016 Hens B, Corsetti M, Spiller R, Marciani L, Vanuytsel T, Tack J, Talattof A, Amidon GL, Koziolek M, Weitschies W, Wilson CG, Bennink RJ, Brouwers J, Augustijns P. Exploring Gastrointestinal Variables Affecting Drug and Formulation Behavior: Methodologies, Challenges and Opportunities. International Journal of Pharmaceutics. PMID 27915009 DOI: 10.1016/j.ijpharm.2016.11.063  0.8
2016 Matsui K, Tsume Y, Amidon GE, Amidon GL. The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media. Journal of Pharmaceutical Sciences. PMID 27020985 DOI: 10.1016/j.xphs.2016.02.020  1
2016 Cao F, Amidon GL, Rodriguez-Hornedo N, Amidon GE. Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization. Molecular Pharmaceutics. PMID 26877267 DOI: 10.1021/acs.molpharmaceut.5b00862  0.36
2016 Incecayir T, Sun J, Tsume Y, Xu H, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL. Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue. Journal of Pharmaceutical Sciences. 105: 925-34. PMID 26869437 DOI: 10.1016/j.xphs.2015.11.036  1
2016 Talattof A, Price JC, Amidon GL. Gastrointestinal Motility Variation and Implications for Plasma Level Variation: Oral Drug Products. Molecular Pharmaceutics. PMID 26692042 DOI: 10.1021/acs.molpharmaceut.5b00774  0.36
2016 Al-Gousous J, Amidon GL, Langguth P. Toward Biopredictive Dissolution for Enteric Coated Dosage Forms Molecular Pharmaceutics. 13: 1927-1936. DOI: 10.1021/acs.molpharmaceut.6b00077  1
2015 Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL. Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Molecular Pharmaceutics. 12: 3399-407. PMID 26262434 DOI: 10.1021/acs.molpharmaceut.5b00414  0.72
2015 Matsui K, Tsume Y, Amidon GE, Amidon GL. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Molecular Pharmaceutics. 12: 2418-28. PMID 25985298 DOI: 10.1021/acs.molpharmaceut.5b00135  1
2015 Krieg BJ, Taghavi SM, Amidon GL, Amidon GE. In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases. Journal of Pharmaceutical Sciences. PMID 25980464 DOI: 10.1002/jps.24460  1
2015 Tsume Y, Takeuchi S, Matsui K, Amidon GE, Amidon GL. In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 76: 203-12. PMID 25978875 DOI: 10.1016/j.ejps.2015.05.013  1
2015 Ozawa M, Tsume Y, Zur M, Dahan A, Amidon GL. Intestinal permeability study of minoxidil: assessment of minoxidil as a high permeability reference drug for biopharmaceutics classification. Molecular Pharmaceutics. 12: 204-11. PMID 25423288 DOI: 10.1021/mp500553b  1
2015 Matsui K, Tsume Y, Amidon GE, Amidon GL. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents Molecular Pharmaceutics. 12: 2418-2428. DOI: 10.1021/acs.molpharmaceut.5b00135  1
2015 Tsume Y, Takeuchi S, Matsui K, Amidon GE, Amidon GL. In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib European Journal of Pharmaceutical Sciences. 76: 203-212. DOI: 10.1016/j.ejps.2015.05.013  1
2014 Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski CP, Amidon GL. Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Molecular Pharmaceutics. 11: 4385-94. PMID 25365774 DOI: 10.1021/mp500483v  1
2014 Takeuchi S, Tsume Y, Amidon GE, Amidon GL. Evaluation of a three compartment in vitro gastrointestinal simulator dissolution apparatus to predict in vivo dissolution. Journal of Pharmaceutical Sciences. 103: 3416-22. PMID 25251982 DOI: 10.1002/jps.24112  1
2014 Walls ZF, Gupta SV, Amidon GL, Lee KD. Synthesis and characterization of valyloxy methoxy luciferin for the detection of valacyclovirase and peptide transporter. Bioorganic & Medicinal Chemistry Letters. 24: 4781-3. PMID 25240255 DOI: 10.1016/j.bmcl.2014.09.011  1
2014 Krieg BJ, Taghavi SM, Amidon GL, Amidon GE. In vivo predictive dissolution: transport analysis of the CO2 , bicarbonate in vivo buffer system. Journal of Pharmaceutical Sciences. 103: 3473-90. PMID 25212721 DOI: 10.1002/jps.24108  1
2014 Mudie DM, Murray K, Hoad CL, Pritchard SE, Garnett MC, Amidon GL, Gowland PA, Spiller RC, Amidon GE, Marciani L. Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state. Molecular Pharmaceutics. 11: 3039-47. PMID 25115349 DOI: 10.1021/mp500210c  1
2014 Shah VP, Amidon GL. G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413-420, 1995--backstory of BCS. The Aaps Journal. 16: 894-8. PMID 24961917 DOI: 10.1208/s12248-014-9620-9  1
2014 Dahan A, Wolk O, Zur M, Amidon GL, Abrahamsson B, Cristofoletti R, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Dressman JB. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate. Journal of Pharmaceutical Sciences. 103: 1592-600. PMID 24788239 DOI: 10.1002/jps.23977  1
2014 Zur M, Gasparini M, Wolk O, Amidon GL, Dahan A. The low/high BCS permeability class boundary: physicochemical comparison of metoprolol and labetalol. Molecular Pharmaceutics. 11: 1707-14. PMID 24735251 DOI: 10.1021/mp500152y  0.64
2014 Tsume Y, Mudie DM, Langguth P, Amidon GE, Amidon GL. The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 57: 152-63. PMID 24486482 DOI: 10.1016/j.ejps.2014.01.009  1
2014 Tsume Y, Borras Bermejo B, Amidon GL. The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs. Pharmaceuticals (Basel, Switzerland). 7: 169-91. PMID 24473270 DOI: 10.3390/ph7020169  1
2014 Tsume Y, Incecayir T, Song X, Hilfinger JM, Amidon GL. The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 86: 514-23. PMID 24361461 DOI: 10.1016/j.ejpb.2013.12.009  1
2014 Radwan A, Wagner M, Amidon GL, Langguth P. Bio-predictive tablet disintegration: effect of water diffusivity, fluid flow, food composition and test conditions. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 57: 273-9. PMID 24036239 DOI: 10.1016/j.ejps.2013.08.038  0.56
2013 Dahan A, Wolk O, Kim YH, Ramachandran C, Crippen GM, Takagi T, Bermejo M, Amidon GL. Purely in silico BCS classification: science based quality standards for the world's drugs. Molecular Pharmaceutics. 10: 4378-90. PMID 24094040 DOI: 10.1021/mp400485k  1
2013 Heinen CA, Reuss S, Amidon GL, Langguth P. Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride. Molecular Pharmaceutics. 10: 3989-96. PMID 23750707 DOI: 10.1021/mp400179v  0.56
2013 Radwan A, Ebert S, Amar A, Münnemann K, Wagner M, Amidon GL, Langguth P. Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms. Molecular Pharmaceutics. 10: 2283-90. PMID 23600970 DOI: 10.1021/mp3006209  1
2013 Sabit H, Dahan A, Sun J, Provoda CJ, Lee KD, Hilfinger JH, Amidon GL. Cytomegalovirus protease targeted prodrug development. Molecular Pharmaceutics. 10: 1417-24. PMID 23485093 DOI: 10.1021/mp3007067  1
2013 Fong SY, Liu M, Wei H, Löbenberg R, Kanfer I, Lee VH, Amidon GL, Zuo Z. Establishing the pharmaceutical quality of Chinese herbal medicine: a provisional BCS classification. Molecular Pharmaceutics. 10: 1623-43. PMID 23473440 DOI: 10.1021/mp300502m  0.56
2013 Xu H, Sabit H, Amidon GL, Showalter HD. An improved synthesis of a fluorophosphonate-polyethylene glycol-biotin probe and its use against competitive substrates. Beilstein Journal of Organic Chemistry. 9: 89-96. PMID 23400700 DOI: 10.3762/bjoc.9.12  1
2013 Incecayir T, Tsume Y, Amidon GL. Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification. Molecular Pharmaceutics. 10: 958-66. PMID 23327720 DOI: 10.1021/mp300410n  1
2013 Gupta D, Varghese Gupta S, Dahan A, Tsume Y, Hilfinger J, Lee KD, Amidon GL. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue. Molecular Pharmaceutics. 10: 512-22. PMID 23244438 DOI: 10.1021/mp300564v  1
2013 Tsume Y, Amidon GL, Takeuchi S. Dissolution effect of gastric and intestinal pH fora BCS class II drug, pioglitazone: New in vitro dissolution system to predict in vivo dissolution Journal of Bioequivalence and Bioavailability. 5: 224-227. DOI: 10.4172/jbb.1000162  1
2012 Abdel-Rahman SM, Amidon GL, Kaul A, Lukacova V, Vinks AA, Knipp GT. Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group. Clinical Therapeutics. 34: S11-24. PMID 23149009 DOI: 10.1016/j.clinthera.2012.09.014  1
2012 Tsume Y, Amidon GL. Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenates. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 15: 433-46. PMID 22974791  1
2012 Mudie DM, Shi Y, Ping H, Gao P, Amidon GL, Amidon GE. Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus. Biopharmaceutics & Drug Disposition. 33: 378-402. PMID 22847296 DOI: 10.1002/bdd.1803  0.56
2012 Tsume Y, Langguth P, Garcia-Arieta A, Amidon GL. In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen. Biopharmaceutics & Drug Disposition. 33: 366-77. PMID 22815122 DOI: 10.1002/bdd.1800  1
2012 Smith DE, Rowland M, Giacomini KM, Amidon GL. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharmaceutical Research. 29: 2345-53. PMID 22814901 DOI: 10.1007/s11095-012-0808-3  1
2012 Radwan A, Amidon GL, Langguth P. Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Biopharmaceutics & Drug Disposition. 33: 403-16. PMID 22782559 DOI: 10.1002/bdd.1798  1
2012 Yi H, Cho HJ, Cho SM, Jo K, Park JA, Kim NH, Amidon GL, Kim JS, Shin HC. Blockade of interleukin-6 receptor suppresses the proliferation of H460 lung cancer stem cells. International Journal of Oncology. 41: 310-6. PMID 22552503 DOI: 10.3892/ijo.2012.1447  0.76
2012 Dahan A, Lennernäs H, Amidon GL. The fraction dose absorbed, in humans, and high jejunal human permeability relationship. Molecular Pharmaceutics. 9: 1847-51. PMID 22524707 DOI: 10.1021/mp300140h  1
2012 Tsume Y, Amidon GL. The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. Molecules (Basel, Switzerland). 17: 3672-89. PMID 22450679 DOI: 10.3390/molecules17043672  1
2012 Waldmann S, Almukainzi M, Bou-Chacra NA, Amidon GL, Lee BJ, Feng J, Kanfer I, Zuo JZ, Wei H, Bolger MB, Löbenberg R. Provisional biopharmaceutical classification of some common herbs used in Western medicine. Molecular Pharmaceutics. 9: 815-22. PMID 22352942 DOI: 10.1021/mp200162b  0.56
2011 Gupta SV, Gupta D, Sun J, Dahan A, Tsume Y, Hilfinger J, Lee KD, Amidon GL. Enhancing the intestinal membrane permeability of zanamivir: a carrier mediated prodrug approach. Molecular Pharmaceutics. 8: 2358-67. PMID 21905667 DOI: 10.1021/mp200291x  1
2011 Miller JM, Beig A, Krieg BJ, Carr RA, Borchardt TB, Amidon GE, Amidon GL, Dahan A. The solubility-permeability interplay: mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation. Molecular Pharmaceutics. 8: 1848-56. PMID 21800883 DOI: 10.1021/mp200181v  0.64
2011 Amidon KS, Langguth P, Lennernäs H, Yu L, Amidon GL. Bioequivalence of oral products and the biopharmaceutics classification system: Science, regulation, and public policy Clinical Pharmacology and Therapeutics. 90: 467-470. PMID 21775984 DOI: 10.1038/clpt.2011.109  1
2011 Tsume Y, Hilfinger JM, Amidon GL. Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study. Pharmaceutical Research. 28: 2575-88. PMID 21671137 DOI: 10.1007/s11095-011-0485-7  1
2011 Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharmaceutical Research. 28: 1774-8. PMID 21491148 DOI: 10.1007/s11095-011-0438-1  1
2011 Tsume Y, Provoda CJ, Amidon GL. The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 879: 915-20. PMID 21450537 DOI: 10.1016/j.jchromb.2011.02.045  1
2011 Sun J, Miller JM, Beig A, Rozen L, Amidon GL, Dahan A. Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality. Expert Opinion On Drug Metabolism & Toxicology. 7: 313-23. PMID 21235283 DOI: 10.1517/17425255.2011.550875  0.68
2011 Amidon GL. Foreword Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications. DOI: 10.1002/9781118067598  1
2010 Sun J, Dahan A, Walls ZF, Lai L, Lee KD, Amidon GL. Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect. Molecular Pharmaceutics. 7: 2362-8. PMID 21028903 DOI: 10.1021/mp100300k  1
2010 Mudie DM, Amidon GL, Amidon GE. Physiological parameters for oral delivery and in vitro testing. Molecular Pharmaceutics. 7: 1388-405. PMID 20822152 DOI: 10.1021/mp100149j  1
2010 Dahan A, Miller JM, Hilfinger JM, Yamashita S, Yu LX, Lennernäs H, Amidon GL. High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations. Molecular Pharmaceutics. 7: 1827-34. PMID 20701326 DOI: 10.1021/mp100175a  0.8
2010 Dahan A, Amidon GL, Zimmermann EM. Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update. Expert Review of Clinical Immunology. 6: 543-50. PMID 20594127 DOI: 10.1586/eci.10.30  1
2010 Tsume Y, Amidon GL. The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation. Molecular Pharmaceutics. 7: 1235-43. PMID 20557130 DOI: 10.1021/mp100053q  1
2010 Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir. Molecular Pharmaceutics. 7: 1223-34. PMID 20536260 DOI: 10.1021/mp100050d  0.64
2010 Dahan A, Miller JM, Hoffman A, Amidon GE, Amidon GL. The solubility-permeability interplay in using cyclodextrins as pharmaceutical solubilizers: mechanistic modeling and application to progesterone. Journal of Pharmaceutical Sciences. 99: 2739-49. PMID 20039391 DOI: 10.1002/jps.22033  1
2010 Tehler U, Nelson CH, Peterson LW, Provoda CJ, Hilfinger JM, Lee KD, McKenna CE, Amidon GL. Puromycin-sensitive aminopeptidase: an antiviral prodrug activating enzyme. Antiviral Research. 85: 482-9. PMID 19969024 DOI: 10.1016/j.antiviral.2009.12.003  1
2010 Sun J, Dahan A, Amidon GL. Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach. Journal of Medicinal Chemistry. 53: 624-32. PMID 19957998 DOI: 10.1021/jm9011559  1
2010 Dahan A, Amidon GL. MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting. International Journal of Pharmaceutics. 386: 216-20. PMID 19944137 DOI: 10.1016/j.ijpharm.2009.11.021  1
2009 Dahan A, Miller JM, Amidon GL. Prediction of solubility and permeability class membership: provisional BCS classification of the world's top oral drugs. The Aaps Journal. 11: 740-6. PMID 19876745 DOI: 10.1208/s12248-009-9144-x  0.64
2009 Shin HC, Kim HR, Cho HJ, Yi H, Cho SM, Lee DG, Abd El-Aty AM, Kim JS, Sun D, Amidon GL. Comparative gene expression of intestinal metabolizing enzymes. Biopharmaceutics & Drug Disposition. 30: 411-21. PMID 19746353 DOI: 10.1002/bdd.675  0.76
2009 Dahan A, Sabit H, Amidon GL. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2028-36. PMID 19589874 DOI: 10.1124/dmd.109.028282  1
2009 Gupta D, Gupta SV, Lee KD, Amidon GL. Chemical and enzymatic stability of amino acid prodrugs containing methoxy, ethoxy and propylene glycol linkers. Molecular Pharmaceutics. 6: 1604-11. PMID 19566080 DOI: 10.1021/mp900084v  0.8
2009 Dahan A, Amidon GL. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G371-7. PMID 19541926 DOI: 10.1152/ajpgi.00102.2009  0.64
2009 Foster DR, Gonzales JP, Amidon GL, Welage LS. Intestinal dipeptide absorption is preserved during thermal injury and cytokine treatment. Jpen. Journal of Parenteral and Enteral Nutrition. 33: 520-8. PMID 19443858 DOI: 10.1177/0148607109333002  1
2009 Dahan A, Sabit H, Amidon GL. The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. The Aaps Journal. 11: 205-13. PMID 19319690 DOI: 10.1208/s12248-009-9092-5  1
2009 Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society. 137: 31-7. PMID 19264104 DOI: 10.1016/j.jconrel.2009.02.018  0.64
2009 Dahan A, Amidon GL. Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs. Molecular Pharmaceutics. 6: 19-28. PMID 19248230 DOI: 10.1021/mp800088f  1
2009 Foster DR, Yee S, Bleske BE, Carver PL, Shea MJ, Menon SS, Ramachandran C, Welage LS, Amidon GL. Lack of interaction between the peptidomimetic substrates captopril and cephradine. Journal of Clinical Pharmacology. 49: 360-7. PMID 19246733 DOI: 10.1177/0091270008329554  1
2009 Sheng JJ, McNamara DP, Amidon GL. Toward an in vivo dissolution methodology: a comparison of phosphate and bicarbonate buffers. Molecular Pharmaceutics. 6: 29-39. PMID 19183104 DOI: 10.1021/mp800148u  1
2009 Foster DR, Landowski CP, Zheng X, Amidon GL, Welage LS. Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacological Research. 59: 215-20. PMID 19084598 DOI: 10.1016/j.phrs.2008.11.001  1
2009 Dahan A, Amidon GL. Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. Pharmaceutical Research. 26: 883-92. PMID 19048359 DOI: 10.1007/s11095-008-9789-7  1
2009 Dahan A, West BT, Amidon GL. Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 36: 320-9. PMID 19028572 DOI: 10.1016/j.ejps.2008.10.013  1
2008 Tsume Y, Vig BS, Sun J, Landowski CP, Hilfinger JM, Ramachandran C, Amidon GL. Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules (Basel, Switzerland). 13: 1441-54. PMID 18719516  1
2008 Polli JE, Abrahamsson BS, Yu LX, Amidon GL, Baldoni JM, Cook JA, Fackler P, Hartauer K, Johnston G, Krill SL, Lipper RA, Malick WA, Shah VP, Sun D, Winkle HN, et al. Summary workshop report: bioequivalence, biopharmaceutics classification system, and beyond. The Aaps Journal. 10: 373-9. PMID 18679807 DOI: 10.1208/s12248-008-9040-9  1
2008 Tsume Y, Hilfinger JM, Amidon GL. Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Molecular Pharmaceutics. 5: 717-27. PMID 18652477 DOI: 10.1021/mp800008c  1
2008 Higaki K, Choe SY, Löbenberg R, Welage LS, Amidon GL. Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 70: 313-25. PMID 18434110 DOI: 10.1016/j.ejpb.2008.02.022  1
2008 Sheng JJ, Sirois PJ, Dressman JB, Amidon GL. Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed. Journal of Pharmaceutical Sciences. 97: 4815-29. PMID 18314890 DOI: 10.1002/jps.21345  0.52
2008 Lai L, Xu Z, Zhou J, Lee KD, Amidon GL. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. The Journal of Biological Chemistry. 283: 9318-27. PMID 18256025 DOI: 10.1074/jbc.M709530200  0.8
2008 Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharmaceutical Research. 25: 483-8. PMID 18236138 DOI: 10.1007/s11095-007-9523-x  1
2008 Tubic-Grozdanis M, Hilfinger JM, Amidon GL, Kim JS, Kijek P, Staubach P, Langguth P. Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. Pharmaceutical Research. 25: 1591-600. PMID 18213452 DOI: 10.1007/s11095-007-9519-6  0.8
2008 Granero GE, Amidon GL. Possibility of enterohepatic recycling of ketoprofen in dogs. International Journal of Pharmaceutics. 349: 166-71. PMID 17890028 DOI: 10.1016/j.ijpharm.2007.08.005  1
2008 Amidon GL, Wagner CR, Lee KD. A letter from the editors. RE: Impact factors Molecular Pharmaceutics. 5: 472.  1
2007 Kim HR, Park SW, Cho HJ, Chae KA, Sung JM, Kim JS, Landowski CP, Sun D, Abd El-Aty AM, Amidon GL, Shin HC. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacological Research. 56: 224-36. PMID 17681807 DOI: 10.1016/j.phrs.2007.06.005  1
2007 Mittal S, Tsume Y, Landowski CP, Lee KD, Hilfinger JM, Amidon GL. Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 67: 752-8. PMID 17560100 DOI: 10.1016/j.ejpb.2007.03.024  1
2007 Mittal S, Song X, Vig BS, Amidon GL. Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. Pharmaceutical Research. 24: 1290-8. PMID 17377743 DOI: 10.1007/s11095-007-9249-9  0.8
2006 Kim JS, Mitchell S, Kijek P, Tsume Y, Hilfinger J, Amidon GL. The suitability of an in situ perfusion model for permeability determinations: utility for BCS class I biowaiver requests. Molecular Pharmaceutics. 3: 686-94. PMID 17140256 DOI: 10.1021/mp060042f  1
2006 Takagi T, Ramachandran C, Bermejo M, Yamashita S, Yu LX, Amidon GL. A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan. Molecular Pharmaceutics. 3: 631-43. PMID 17140251 DOI: 10.1021/mp0600182  0.68
2006 Sheng JJ, Kasim NA, Chandrasekharan R, Amidon GL. Solubilization and dissolution of insoluble weak acid, ketoprofen: effects of pH combined with surfactant. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 29: 306-14. PMID 16982177 DOI: 10.1016/j.ejps.2006.06.006  1
2006 Granero GE, Ramachandran C, Amidon GL. Rapid in vivo dissolution of ketoprofen: Implications on the biopharmaceutics classification system Pharmazie. 61: 673-676. PMID 16964708  1
2006 Cao X, Gibbs ST, Fang L, Miller HA, Landowski CP, Shin HC, Lennernas H, Zhong Y, Amidon GL, Yu LX, Sun D. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharmaceutical Research. 23: 1675-86. PMID 16841194 DOI: 10.1007/s11095-006-9041-2  1
2006 Granero GE, Amidon GL. Stability of valacyclovir: implications for its oral bioavailability. International Journal of Pharmaceutics. 317: 14-8. PMID 16759825 DOI: 10.1016/j.ijpharm.2006.01.050  1
2006 Jantratid E, Prakongpan S, Amidon GL, Dressman JB. Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine. Clinical Pharmacokinetics. 45: 385-99. PMID 16584285 DOI: 10.2165/00003088-200645040-00004  0.4
2006 Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL. N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1070-7. PMID 16565170 DOI: 10.1124/dmd.105.009209  1
2006 Landowski CP, Lorenzi PL, Song X, Amidon GL. Nucleoside ester prodrug substrate specificity of liver carboxylesterase. The Journal of Pharmacology and Experimental Therapeutics. 316: 572-80. PMID 16223870 DOI: 10.1124/jpet.105.092726  1
2005 Granero GE, Ramachandran C, Amidon GL. Dissolution and solubility behavior of fenofibrate in sodium lauryl sulfate solutions. Drug Development and Industrial Pharmacy. 31: 917-22. PMID 16306004 DOI: 10.1080/03639040500272108  1
2005 Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism. Pharmaceutical Research. 22: 1510-8. PMID 16132363 DOI: 10.1007/s11095-005-6156-9  1
2005 Cao X, Yu LX, Barbaciru C, Landowski CP, Shin HC, Gibbs S, Miller HA, Amidon GL, Sun D. Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability. Molecular Pharmaceutics. 2: 329-40. PMID 16053336 DOI: 10.1021/mp0499104  1
2005 Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 314: 883-90. PMID 15901797 DOI: 10.1124/jpet.104.082412  1
2005 Löbenberg R, Kim JS, Amidon GL. Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 60: 17-23. PMID 15848051 DOI: 10.1016/j.ejpb.2004.11.010  1
2005 Landowski CP, Vig BS, Song X, Amidon GL. Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs. Molecular Cancer Therapeutics. 4: 659-67. PMID 15827340 DOI: 10.1158/1535-7163.MCT-04-0290  1
2005 Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport. Molecular Pharmaceutics. 2: 157-67. PMID 15804190 DOI: 10.1021/mp049888e  1
2005 Amidon GL. Collaborative research training. Molecular Pharmaceutics. 2: 97. PMID 15804183 DOI: 10.1021/mp0580807  1
2005 Mittal S, Song X, Vig BS, Landowski CP, Kim I, Hilfinger JM, Amidon GL. Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs. Molecular Pharmaceutics. 2: 37-46. PMID 15804176 DOI: 10.1021/mp049922p  1
2005 Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter. Journal of Medicinal Chemistry. 48: 1274-7. PMID 15715497 DOI: 10.1021/jm049450i  1
2005 Amidon GL. The "site of action" Molecular Pharmaceutics. 2: 439. DOI: 10.1021/mp058083j  1
2005 Amidon GL. Editorial reflections on the first year of Molecular Pharmaceutics Molecular Pharmaceutics. 2: 1. DOI: 10.1021/mp040012h  1
2004 Kim I, Crippen GM, Amidon GL. Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL. Molecular Pharmaceutics. 1: 434-46. PMID 16028355  1
2004 Amidon GL. Molecular pharmaceutics: the NIH Roadmap and the FDA pipeline problem. Molecular Pharmaceutics. 1: 337. PMID 16026002  1
2004 Kim I, Song X, Vig BS, Mittal S, Shin HC, Lorenzi PJ, Amidon GL. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. Molecular Pharmaceutics. 1: 117-27. PMID 15832508  0.8
2004 Kasim NA, Whitehouse M, Ramachandran C, Bermejo M, Lennernäs H, Hussain AS, Junginger HE, Stavchansky SA, Midha KK, Shah VP, Amidon GL. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Molecular Pharmaceutics. 1: 85-96. PMID 15832504  1
2004 Faria TN, Timoszyk JK, Stouch TR, Vig BS, Landowski CP, Amidon GL, Weaver CD, Wall DA, Smith RL. A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Molecular Pharmaceutics. 1: 67-76. PMID 15832502  1
2004 Amidon GL. Finding the "Magic". Molecular Pharmaceutics. 1: 1. PMID 15832495  1
2004 Landowski CP, Anderle P, Sun D, Sadee W, Amidon GL. Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies. The Aaps Journal. 6: e21. PMID 15760106 DOI: 10.1208/aapsj060321  1
2004 Balakrishnan A, Rege BD, Amidon GL, Polli JE. Surfactant-mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity. Journal of Pharmaceutical Sciences. 93: 2064-75. PMID 15236455 DOI: 10.1002/jps.20118  1
2004 Delaney B, Stevens LA, Schmelzer W, Haworth J, McCurry S, Hilfinger JM, Kim JS, Tsume Y, Amidon GL, Kritchevsky D. Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. The Journal of Nutritional Biochemistry. 15: 289-95. PMID 15135153 DOI: 10.1016/j.jnutbio.2003.08.013  1
2004 Polli JE, Yu LX, Cook JA, Amidon GL, Borchardt RT, Burnside BA, Burton PS, Chen ML, Conner DP, Faustino PJ, Hawi AA, Hussain AS, Joshi HN, Kwei G, Lee VH, et al. Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities. Journal of Pharmaceutical Sciences. 93: 1375-81. PMID 15124197 DOI: 10.1002/jps.20064  1
2004 Sun D, Yu LX, Hussain MA, Wall DA, Smith RL, Amidon GL. In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome. Current Opinion in Drug Discovery & Development. 7: 75-85. PMID 14982151  0.64
2004 Yu LX, Carlin AS, Amidon GL, Hussain AS. Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs. International Journal of Pharmaceutics. 270: 221-7. PMID 14726137  0.64
2003 Landowski CP, Han HK, Lee KD, Amidon GL. A fluorescent hPept1 transporter substrate for uptake screening. Pharmaceutical Research. 20: 1738-45. PMID 14661916 DOI: 10.1023/B:PHAM.0000003369.64891.51  1
2003 Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research. 20: 1381-8. PMID 14567631 DOI: 10.1023/A:1025745824632  1
2003 Shin HC, Kim JC, Chung MK, Jung YH, Kim JS, Lee MK, Amidon GL. Fetal and maternal tissue distribution of the new fluoroquinolone DW-116 in pregnant rats. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 136: 95-102. PMID 14522602  0.76
2003 Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, Levy RJ, Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 92: 173-87. PMID 14499195 DOI: 10.1016/S0168-3659(03)00328-6  1
2003 Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications. 307: 696-703. PMID 12893280 DOI: 10.1016/S0006-291X(03)01259-2  1
2003 Chiu YY, Higaki K, Neudeck BL, Barnett JL, Welage LS, Amidon GL. Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells. Pharmaceutical Research. 20: 749-56. PMID 12751630  0.32
2003 Landowski CP, Sun D, Foster DR, Menon SS, Barnett JL, Welage LS, Ramachandran C, Amidon GL. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. The Journal of Pharmacology and Experimental Therapeutics. 306: 778-86. PMID 12750437 DOI: 10.1124/jpet.103.051011  1
2003 Kim I, Chu XY, Kim S, Provoda CJ, Lee KD, Amidon GL. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. The Journal of Biological Chemistry. 278: 25348-56. PMID 12732646 DOI: 10.1074/jbc.M302055200  0.8
2003 Saito G, Amidon GL, Lee KD. Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential. Gene Therapy. 10: 72-83. PMID 12525839 DOI: 10.1038/sj.gt.3301859  1
2002 Oh DM, Han HK, Williamson RM, Bigge CF, Amidon GL, Stewart BH, Surendran N. Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters. Journal of Pharmaceutical Sciences. 91: 2579-87. PMID 12434401 DOI: 10.1002/jps.10241  1
2002 Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharmaceutical Research. 19: 1400-16. PMID 12425456 DOI: 10.1023/A:1020483911355  1
2002 Su SF, Amidon GL, Lee HJ. Possible degradative process of cholecystokinin analogs in rabbit jejunum brush-border membrane vesicles. Life Sciences. 72: 35-47. PMID 12409143 DOI: 10.1016/S0024-3205(02)02198-7  1
2002 Yu LX, Amidon GL, Polli JE, Zhao H, Mehta MU, Conner DP, Shah VP, Lesko LJ, Chen ML, Lee VH, Hussain AS. Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharmaceutical Research. 19: 921-5. PMID 12180542 DOI: 10.1023/A:1016473601633  1
2002 Martinez MN, Amidon GL. A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. Journal of Clinical Pharmacology. 42: 620-43. PMID 12043951 DOI: 10.1177/00970002042006005  1
2002 Lee HJ, Amidon GL. The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats. Biopharmaceutics & Drug Disposition. 23: 131-41. PMID 12015787 DOI: 10.1002/bdd.302  1
2002 Li LY, Amidon GL, Kim JS, Heimbach T, Kesisoglou F, Topliss JT, Fleisher D. Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat. The Journal of Pharmacology and Experimental Therapeutics. 301: 586-93. PMID 11961060  0.52
2002 Su SF, Amidon GL, Lee HJ. Intestinal metabolism and absorption of cholecystokinin analogs in rats. Biochemical and Biophysical Research Communications. 292: 632-8. PMID 11922613 DOI: 10.1006/bbrc.2002.6718  1
2002 Takamatsu N, Welage LS, Hayashi Y, Yamamoto R, Barnett JL, Shah VP, Lesko LJ, Ramachandran C, Amidon GL. Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 53: 37-47. PMID 11777751  0.68
2001 Sun D, Landowski CP, Chu X, Wallsten R, Komorowski TE, Fleisher D, Amidon GL. Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein. Aaps Pharmsci. 3: E2. PMID 11741253 DOI: 10.1208/ps030102  1
2001 Choe SY, Neudeck BL, Welage LS, Amidon GE, Barnett JL, Amidon GL. Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 14: 347-53. PMID 11684410 DOI: 10.1016/S0928-0987(01)00196-8  1
2001 Higaki K, Yamashita S, Amidon GL. Time-dependent oral absorption models Journal of Pharmacokinetics and Pharmacodynamics. 28: 109-128. PMID 11381566 DOI: 10.1023/A:1011573831444  1
2000 Han HK, Amidon GL. Targeted prodrug design to optimize drug delivery Aaps Pharmsci [Electronic Resource]. 2. PMID 11741222 DOI: 10.1208/ps020106  1
2000 Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards European Journal of Pharmaceutics and Biopharmaceutics. 50: 3-12. PMID 10840189 DOI: 10.1016/S0939-6411(00)00091-6  1
2000 Hanx HK, Amidon GL. Designing prodrugs for the hPEPT1 transporter Acs Symposium Series. 752: 46-53.  1
1999 Pang DC, Amidon GL, Preusch PC, Sadée W. Second AAPS-NIH frontier symposium 1999: membrane transporters and drug therapy. American Association of Pharmaceutical Scientists Aaps Pharmsci [Electronic Resource]. 1. PMID 11780607  1
1999 Oh DM, Han HK, Amidon GL. Drug transport and targeting. Intestinal transport Pharmaceutical Biotechnology. 12: 59-88. PMID 10742972  1
1999 Oh DM, Amidon GL. Overview of membrane transport Pharmaceutical Biotechnology. 12: 1-27. PMID 10742970  1
1999 Lipka E, Amidon GL. Setting bioequivalence requirements for drug development based on preclinical data: Optimizing oral drug delivery systems Journal of Controlled Release. 62: 41-49. PMID 10518633 DOI: 10.1016/S0168-3659(99)00022-X  1
1999 Yu LX, Amidon GL. A compartmental absorption and transit model for estimating oral drug absorption International Journal of Pharmaceutics. 186: 119-125. PMID 10486429 DOI: 10.1016/S0378-5173(99)00147-7  1
1999 Markland P, Amidon GL, Yang VC. Modified polypeptides containing γ-benzyl glutamic acid as drug delivery platforms International Journal of Pharmaceutics. 178: 183-192. PMID 10205638 DOI: 10.1016/S0378-5173(98)00373-1  1
1999 Amidon GL, Walgreen CR. "5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter," Pharmaceutical Research. 16: 175. PMID 10100299  1
1999 Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL. CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. Journal of Pharmaceutical Sciences. 88: 347-50. PMID 10052994 DOI: 10.1021/js980132e  1
1999 Amidon GL, Walgreen C.R. J. Letter to the editor Pharmaceutical Research. 16: 175. DOI: 10.1023/A:1011955803803  1
1998 Croyle MA, Stone M, Amidon GL, Roessler BJ. In vitro and in vivo asessment of adenovirus 41 as a vector for gene delivery to the intestine Gene Therapy. 5: 645-654. PMID 9797869  1
1998 Han HK, Oh DM, Amidon GL. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter Pharmaceutical Research. 15: 1382-1386. PMID 9755889 DOI: 10.1023/A:1011945420235  1
1998 Endrenyi L, Amidon GL, Midha KK, Skelly JP. Individual bioequivalence: Attractive in principle, difficult in practice Pharmaceutical Research. 15: 1321-1325. PMID 9755880 DOI: 10.1023/A:1011972732530  1
1998 Yu LX, Amidon GL. Saturable small intestinal drug absorption in humans: Modeling and interpretation of cefatrizine data European Journal of Pharmaceutics and Biopharmaceutics. 45: 199-203. PMID 9704917 DOI: 10.1016/S0939-6411(97)00088-X  1
1998 Dressman JB, Amidon GL, Reppas C, Shah VP. Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms Pharmaceutical Research. 15: 11-22. PMID 9487541 DOI: 10.1023/A:1011984216775  1
1998 Yu LX, Amidon GL. Characterization of small intestinal transit time distribution in humans International Journal of Pharmaceutics. 171: 157-163. DOI: 10.1016/S0378-5173(98)00174-4  1
1998 Amidon GL. Glut of Ph.D.'s? Consider pharmaceutical sciences Scientist. 12.  1
1998 Crison JR, Lipka E, Amidon GL. Effect of release rate and permeability on fraction dose absorbed of a highly soluble drug in the ascending colon Proceedings of the Controlled Release Society. 471-472.  1
1997 Bowe CL, Mokhtarzadeh L, Venkatesan P, Babu S, Axelrod HR, Sofia MJ, Kakarla R, Chan TY, Kim JS, Lee HJ, Amidon GL, Choe SY, Walker S, Kahne D. Design of compounds that increase the absorption of polar molecules. Proceedings of the National Academy of Sciences of the United States of America. 94: 12218-23. PMID 9342389 DOI: 10.1073/pnas.94.22.12218  1
1997 Walter E, Croyle MA, Roessler BJ, Amidon GL. The absence of accessible vitronectin receptors in differentiated tissue hinders adenoviral-mediated gene transfer to the intestinal epithelium in vitro. Pharmaceutical Research. 14: 1216-22. PMID 9327451 DOI: 10.1023/A:1012163025455  1
1997 Crison JR, Weiner ND, Amidon GL. Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate. Journal of Pharmaceutical Sciences. 86: 384-8. PMID 9050810 DOI: 10.1021/js960105t  1
1997 Cook TJ, Amidon GL, Yang VC. Polypeptides for controlled release applications: Synthesis and preliminary characterization and release studies International Journal of Pharmaceutics. 159: 197-206. DOI: 10.1016/S0378-5173(97)00308-6  1
1997 Croyle MA, Roessler BJ, Amidon GL. Beta cyclodextrins enhance gene delivery to the intestine Proceedings of the Controlled Release Society. 675-676.  1
1997 Rhie JK, Covitz KMY, Sadee W, Amidon GL. Uptake of peptidomimetics in cho-pept1 transfected cells Proceedings of the Controlled Release Society. 389-390.  1
1996 Lipka E, Crison J, Amidon GL. Transmembrane transport of peptide type compounds: Prospects for oral delivery Journal of Controlled Release. 39: 121-129. PMID 11539926 DOI: 10.1016/0168-3659(95)00145-X  1
1996 Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: Effect of particle size Pharmaceutical Research. 13: 1838-1845. PMID 8987081 DOI: 10.1023/A:1016085108889  1
1996 Covitz KMY, Amidon GL, Sadée W. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells Pharmaceutical Research. 13: 1631-1634. PMID 8956326 DOI: 10.1023/A:1016476220296  1
1996 Polli JE, Crison JR, Amidon GL. Novel approach to the analysis of in vitro-in vivo relationships Journal of Pharmaceutical Sciences. 85: 753-760. PMID 8819002 DOI: 10.1021/js9503587  1
1996 Yu LX, Crison JR, Amidon GL. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans International Journal of Pharmaceutics. 140: 111-118. DOI: 10.1016/0378-5173(96)04592-9  1
1996 Walter E, Kissel T, Amidon GL. The intestinal peptide carrier: A potential transport system for small peptide derived drugs Advanced Drug Delivery Reviews. 20: 33-58. DOI: 10.1016/0169-409X(95)00129-U  1
1996 Sakon K, Amidon GL. Intestinal metabolism and absorption of fibrin anti-polymerant peptide, Gly-Pro-Arg Proceedings of the Controlled Release Society. 595-596.  1
1996 Crison JR, Siersma PR, Amidon GL. A novel programmable oral release technology for delivering drugs: Human feasibility testing using gamma scintigraphy Proceedings of the Controlled Release Society. 51-52.  1
1995 Lennernäs H, Crison JR, Amidon GL. Permeability and clearance views of drug absorption: A commentary Journal of Pharmacokinetics and Biopharmaceutics. 23: 333-337. PMID 8834200 DOI: 10.1007/BF02354289  1
1995 Sadée W, Drübbisch V, Amidon GL. Biology of Membrane Transport Proteins Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1823-1837. PMID 8786953 DOI: 10.1023/A:1016211015926  1
1995 Polli JE, Amidon GL. Mathematical model and dimensional analysis of glycocholate binding to cholestyramine resin: Implications for in vivo resin performance Journal of Pharmaceutical Sciences. 84: 1446-1454. PMID 8748328 DOI: 10.1002/jps.2600841212  1
1995 Lee HJ, Amidon GL. Oral peptide delivery: Improving the systemic availability of small peptides and enkephalin analogs Nida Research Monograph Series. 86-106. PMID 8606751  1
1995 Polli JE, Amidon GL. In vitro characterization of sodium glycocholate binding to cholestyramine resin Journal of Pharmaceutical Sciences. 84: 55-61. PMID 7714745 DOI: 10.1002/jps.2600840114  1
1995 Choi HK, Flynn GL, Amidon GL. Percutaneous absorption and dermal delivery of cyclosporin A Journal of Pharmaceutical Sciences. 84: 581-583. PMID 7658348 DOI: 10.1002/jps.2600840512  1
1995 Su SF, Amidon GL. Investigation into the intestinal metabolism of [D-Ala1] peptide T amide: implication for oral drug delivery. Biochimica Et Biophysica Acta. 1245: 62-8. PMID 7654767 DOI: 10.1016/0304-4165(95)00063-H  1
1995 Amidon GL, Lennernäs H, Shah VP, Crison JR. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 413-420. PMID 7617530 DOI: 10.1023/A:1016212804288  1
1995 Mummaneni V, Amidon GL, Dressman JB. Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 780-786. PMID 7479568 DOI: 10.1023/A:1016284214708  1
1995 Oh DM, Curl RL, Yong CS, Amidon GL. Effect of micronization on the extent of drug absorption from suspensions in humans Archives of Pharmacal Research. 18: 427-433. DOI: 10.1007/BF02976347  1
1994 Langguth P, Merkle HP, Amidon GL. Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11: 528-535. PMID 8058610 DOI: 10.1023/A:1018962415287  1
1994 Amidon GL, Lee HJ. Absorption of peptide and peptidomimetic drugs Annual Review of Pharmacology and Toxicology. 34: 321-341. PMID 8042854  1
1994 Yuasa H, Fleisher D, Amidon GL. Noncompetitive inhibition of cephradine uptake by enalapril in rabbit intestinal brush-border membrane vesicles: An enalapril specific inhibitory binding site on the peptide carrier Journal of Pharmacology and Experimental Therapeutics. 269: 1107-1111. PMID 8014854  1
1994 Schwendeman SP, Amidon GL, Labhasetwar V, Levy RJ. Modulated drug release using iontophoresis through heterogeneous cation- exchange membranes. 2. Influence of cation-exchanger content on membrane resistance and characteristic times Journal of Pharmaceutical Sciences. 83: 1482-1494. PMID 7884674 DOI: 10.1002/jps.2600831023  1
1994 Oh DM, Amidon GL. Prediction of drug-drug interaction during oral absorption of carrier-mediated compounds in humans Archives of Pharmacal Research. 17: 364-370. DOI: 10.1007/BF02974178  1
1994 Crison JR, Amidon GL. Theoretical approach to controlled delivery of water insoluble drugs based on solubility and surface area Proceedings of the Controlled Release Society. 706-707.  1
1994 Lee HJ, Amidon GL, Yek LY. Biopharmaceutics and pharmacokinetics of [D-ala2, D-leu5]enkephalin after various routes of administration Journal of Controlled Release. 28: 305.  1
1994 Sherman LB, Crison JR, Amidon GL. Optimization of the water permeability of cellulosic films and coatings Proceedings of the Controlled Release Society. 718-719.  1
1994 Davidson BL, Croyle MA, Roesseler BJ, Amidon GL. Pharmaceutical stabilization of adenoviral vectors Proceedings of the Controlled Release Society. 796-797.  1
1994 Fox AS, Crison JR, Lin SY, Amidon GL. PVP-based hydrogels for controlled drug delivery Proceedings of the Controlled Release Society. 481-482.  1
1993 Lin SY, Amidon GL, Weiner ND, Goldberg AH. Viscoelasticity of anionic polymers and their mucociliary transport on the frog palate. Pharmaceutical Research. 10: 411-7. PMID 8464815 DOI: 10.1023/A:1018944507303  1
1993 Guo JH, Robertson RE, Amidon GL. An Investigation into the Mechanical and Transport Properties of Aqueous Latex Films: A New Hypothesis for the Film-Forming Mechanism of Aqueous Dispersion System Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 405-410. PMID 8464814 DOI: 10.1023/A:1018992423232  1
1993 Yuasa H, Amidon GL, Fleisher D. Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and Inhibition Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 400-404. PMID 8464813 DOI: 10.1023/A:1018940306394  1
1993 Sinko PJ, Leesman GD, Amidon GL. Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 271-275. PMID 8456076 DOI: 10.1023/A:1018999130076  1
1993 Oh DM, Curl RL, Amidon GL. Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 264-270. PMID 8456075 DOI: 10.1023/A:1018947113238  1
1993 Luner PE, Amidon GL. Description and simulation of a multiple mixing tank model to predict the effect of bile sequestrants on bile salt excretion Journal of Pharmaceutical Sciences. 82: 311-318. PMID 8450428 DOI: 10.1002/jps.2600820319  1
1993 Oh DM, Sinko PJ, Amidon GL. Characterization of the oral absorption of some β-lactams: Effect of the α-amino side chain group Journal of Pharmaceutical Sciences. 82: 897-900. PMID 8229687 DOI: 10.1002/jps.2600820907  1
1993 Langguth P, Merkle HP, Amidon GL. Site-dependent intestinal metabolism and absorption of the pentapeptide metkephamid Proceedings of the Controlled Release Society. 180-181.  1
1992 Doo-Man Oh, Sinko PJ, Amidon GL. Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ International Journal of Pharmaceutics. 85: 181-187. PMID 11537280 DOI: 10.1016/0378-5173(92)90147-T  1
1992 Luner PE, Amidon GL. Equilibrium and Kinetic Factors Influencing Bile Sequestrant Efficacy Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 9: 670-676. PMID 1608901 DOI: 10.1023/A:1015862329303  1
1992 Guo JH, Robertson RE, Amidon GL. Thermodynamic aspects of the disappearance of antiplasticization in slightly plasticized polymer films at high temperature [2] Journal of Pharmaceutical Sciences. 81: 1229-1230. PMID 1491347 DOI: 10.1002/jps.2600811222  1
1992 Bai JPF, Amidon GL. Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 9: 969-978. PMID 1409387 DOI: 10.1023/A:1015885823793  1
1991 Sinko CM, Yee AF, Amidon GL. Prediction of physical aging in controlled-release coatings: the application of the relaxation coupling model to glassy cellulose acetate. Pharmaceutical Research. 8: 698-705. PMID 2062799 DOI: 10.1023/A:1015837614475  1
1991 Kou JH, Fleisher D, Amidon GL. Calculation of the Aqueous Diffusion Layer Resistance for Absorption in a Tube: Application to Intestinal Membrane Permeability Determination Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 298-305. PMID 2052515 DOI: 10.1023/A:1015829128646  1
1991 Choi HK, Amidon GL, Flynn GL. Some general influences of n-decylmethyl sulfoxide on the permeation of drugs across hairless mouse skin Journal of Investigative Dermatology. 96: 822-826. PMID 2045670  1
1991 Friedman DI, Amidon GL. Oral Absorption of Peptides: Influence of pH and Inhibitors on the Intestinal Hydrolysis of Leu-Enkephalin and Analogues Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 93-96. PMID 2014216 DOI: 10.1023/A:1015842609565  1
1991 Sinko PJ, Leesman GD, Amidon GL. Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 979-988. PMID 1924168 DOI: 10.1023/A:1015892621261  1
1991 Bai PF, Subramanian P, Mosberg HI, Amidon GL. Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino Group Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 593-599. PMID 1866373 DOI: 10.1023/A:1015848522228  1
1991 Lui CY, Amidon GL, Goldberg A. Intranasal absorption of flurazepam, midazolam, and triazolam in dogs Journal of Pharmaceutical Sciences. 80: 1125-1129. PMID 1815070  1
1991 Guo JH, Robertson RE, Amidon GL. Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 1500-1504. PMID 1808613 DOI: 10.1023/A:1015890232106  1
1991 Ahn HY, Amidon GL, Smith DE. Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 1186-1190. PMID 1788165 DOI: 10.1023/A:1015866704848  1
1991 Amidon GL, DeBrincat GA, Najib N. Effects of gravity on gastric emptying, intestinal transit, and drug absorption Journal of Clinical Pharmacology. 31: 968-973. PMID 1761729  1
1990 Sinko CM, Yee AF, Amidon GL. The effect of physical aging on the dissolution rate of anionic polyelectrolytes. Pharmaceutical Research. 7: 648-53. PMID 2367333 DOI: 10.1023/A:1015882631082  1
1990 Choi HK, Flynn GL, Amidon GL. Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 1099-1106. PMID 2293206 DOI: 10.1023/A:1015915922363  1
1990 Donovan MD, Flynn GL, Amidon GL. Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 863-868. PMID 2235883 DOI: 10.1023/A:1015921101465  1
1990 Donovan MD, Flynn GL, Amidon GL. The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption Enhancers Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 808-815. PMID 2235878 DOI: 10.1023/A:1015904730599  1
1990 Kou JH, Fleisher D, Amidon GL. Modeling drug release from dynamically swelling poly(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels Journal of Controlled Release. 12: 241-250. DOI: 10.1016/0168-3659(90)90105-3  1
1990 Friedman DI, Amidon GL. Characterization of the intestinal transport parameters for small peptide drugs Journal of Controlled Release. 13: 141-146. DOI: 10.1016/0168-3659(90)90005-E  1
1989 Sinko PJ, Amidon GL. Characterization of the oral absorption of β-lactam antibiotics II: Competitive absorption and peptide carrier specificity Journal of Pharmaceutical Sciences. 78: 723-727. PMID 2585263  1
1989 Friedman DI, Amidon GL. Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and Fosinopril Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 1043-1047. PMID 2560181 DOI: 10.1023/A:1015978420797  1
1989 Friedman DI, Amidon GL. Intestinal absorption mechanism of dipeptide angiotensin converting enzyme inhibitors of the lysyl-proline type: Lisinopril and SQ 29,852 Journal of Pharmaceutical Sciences. 78: 995-998. PMID 2559191  1
1989 Sinko CM, Amidon GL. Plasticizer-induced changes in the mechanical rate of response of film coatings: an approach to quantitating plasticizer effectiveness International Journal of Pharmaceutics. 55: 247-256. DOI: 10.1016/0378-5173(89)90048-3  1
1988 Johnson DA, Amidon GL. Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities Journal of Theoretical Biology. 131: 93-106. PMID 3419195 DOI: 10.1016/S0022-5193(88)80123-1  1
1988 Kou JH, Amidon GL, Lee PI. pH-Dependent Swelling and Solute Diffusion Characteristics of Poly(Hydroxyethyl Methacrylate–CO–Methacrylie Acid) Hydrogels Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 592-597. PMID 3247322 DOI: 10.1023/A:1015998131160  1
1988 Willia NA, Amidon GL. The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 193-195. PMID 3244634 DOI: 10.1023/A:1015925225766  1
1988 Amidon GL, Sinko PJ, Fleisher D. Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 651-654. PMID 3244618 DOI: 10.1023/A:1015927004752  1
1988 Sinko PJ, Amidon GL. Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 645-650. PMID 3244617 DOI: 10.1023/A:1015974920682  1
1988 McNamara DP, Amidon GL. Reaction plane approach for estimating the effects of buffers on the dissolution rate of acidic drugs Journal of Pharmaceutical Sciences. 77: 511-517. PMID 3171931  1
1988 Hu M, Amidon GL. Passive and carrier-mediated intestinal absorption components of captopril Journal of Pharmaceutical Sciences. 77: 1007-1011. PMID 3072405  1
1988 Najib N, Mansour AR, Amidon GL. Gastrointestinal transit time: An in vitro study of parameters controlling the mean relative residence times of particles in a laminar fluid flowin The Chemical Engineering Journal. 37. DOI: 10.1016/0300-9467(88)80017-0  1
1987 Oberle RL, Amidon GL. The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon Journal of Pharmacokinetics and Biopharmaceutics. 15: 529-544. PMID 3694496 DOI: 10.1007/BF01061761  1
1987 Sinko PJ, Ming Hu, Amidon GL. Carrier mediated transport of amino acids, small peptides, and their drug analogs Journal of Controlled Release. 6: 115-121. DOI: 10.1016/0168-3659(87)90069-1  1
1986 Johnson DA, Amidon GL. The effect of enzymatic reaction on dissolution rate: Theoretical analysis and experimental test Journal of Pharmaceutical Sciences. 75: 195-203. PMID 3958933  1
1986 Stewart BH, Amidon GL, Brabec RK. Uptake of prodrugs by rat intestinal mucosal cells: Mechanism and pharmaceutical implications Journal of Pharmaceutical Sciences. 75: 940-945. PMID 3795023  1
1986 Fleisher D, Johnson KC, Stewart BH, Amidon GL. Oral absorption of 21-corticosteroid esters: A function of aqueous stability and intestinal enzyme activity and distribution Journal of Pharmaceutical Sciences. 75: 934-939. PMID 3795022  1
1986 McNamara DP, Amidon GL. Dissolution of acidic and basic compounds from the rotating disk: Influence of convective diffusion and reaction Journal of Pharmaceutical Sciences. 75: 858-868. PMID 3783452  1
1986 Lui CY, Oberle R, Fleisher D, Amidon GL. Application of a radiotelemetric system to evaluate the performance of enteric coated and plain aspirin tablets Journal of Pharmaceutical Sciences. 75: 469-474. PMID 3735085  1
1986 Amidon GL, Merfeld AE, Dressman JB. Concentration and pH dependency of α-methyldopa absorption in rat intestine Journal of Pharmacy and Pharmacology. 38: 363-368. PMID 2872312  1
1985 Amidon GL, Dressman JB. Enteric coated aspirin circumventing gastric retention Journal of Rheumatology. 12: 387-388. PMID 4032418  1
1985 Dressman JB, Amidon GL, Fleisher D. Absorption potential: estimating the fraction absorbed for orally administered compounds Journal of Pharmaceutical Sciences. 74: 588-589. PMID 4020642  1
1985 Johnson K, Amidon GL, Pogany S. Solution kinetics of a water-soluble hydrocortisone prodrug: Hydrocortisone-21-lysinate Journal of Pharmaceutical Sciences. 74: 87-89. PMID 3981427  1
1985 Amidon GL. Fluid mechanics and intestinal transit Gastroenterology. 88: 858. PMID 3967814  1
1985 Fleisher D, Stewart BH, Amidon GL. Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting Methods in Enzymology. 360-381. PMID 3900636  1
1985 Amidon GL, Stewart BH, Pogany S. Improving the intestinal mucosal cell uptake of water insoluble compounds Journal of Controlled Release. 2: 13-26. DOI: 10.1016/0168-3659(85)90029-X  1
1984 Williams NA, Amidon GL. Excess free energy approach to the estimation of solubility in mixed solvent systems. I: Theory Journal of Pharmaceutical Sciences. 73: 9-13. PMID 6694092  1
1984 Williams NA, Amidon GL. Excess free energy approach to the estimation of solubility in mixed solvent systems. III: Ethanol-propylene glycol-water mixtures Journal of Pharmaceutical Sciences. 73: 18-23. PMID 6694075  1
1984 Williams NA, Amidon GL. Excess free energy approach to the estimation of solubility in mixed solvent systems. II: Ethanol-water mixtures Journal of Pharmaceutical Sciences. 73: 14-18. PMID 6694074  1
1984 Dressman JB, Fleisher D, Amidon GL. Physicochemical model for dose-dependent drug absorption Journal of Pharmaceutical Sciences. 73: 1274-1279. PMID 6548523  1
1984 Dressman JB, Amidon GL. Radiotelemetric method for evaluating enteric coatings in vivo Journal of Pharmaceutical Sciences. 73: 935-938. PMID 6470956  1
1983 Van Campen I, Amidon GL, Zografi G. Moisture sorption kinetics for water-soluble substances. III: Theoretical and experimental studies in air Journal of Pharmaceutical Sciences. 72: 1394-1398. PMID 6663472  1
1983 Van Campen L, Amidon GL, Zografi G. Moisture sorption kinetics for water-soluble substances. II: Experimental verification of heat transport control Journal of Pharmaceutical Sciences. 72: 1388-1393. PMID 6663471  1
1983 Van Campen L, Amidon GL, Zografi G. Moisture sorption kinetics for water-soluble substances. I: Theoretical considerations of heat transport control Journal of Pharmaceutical Sciences. 72: 1381-1388. PMID 6663470  1
1983 Amidon GL, Lee M, Lee H. Intestinal absorption of amino acid derivatives: Structural requirements for membrane hydrolysis Journal of Pharmaceutical Sciences. 72: 943-944. PMID 6413676  1
1982 Selen A, Amidon GL, Welling PG. Pharmacokinetics of probenecid following oral doses of human volunteers Journal of Pharmaceutical Sciences. 71: 1238-1242. PMID 7175716  1
1982 Amidon GL, Chang M, Fleisher D, Allen R. Intestinal absorption of amino acid derivatives: Importance of the free α-amino group Journal of Pharmaceutical Sciences. 71: 1138-1141. PMID 7143212  1
1982 Amidon GL, Buckner CK. A theoretical model for the use of functional antagonism to estimate dissociation constants for agonists Journal of Pharmacological Methods. 7: 173-178. PMID 7098500 DOI: 10.1016/0160-5402(82)90030-4  1
1982 Amidon GL, Williams NA. A solubility equation for non-electrolytes in water International Journal of Pharmaceutics. 11: 249-256. DOI: 10.1016/0378-5173(82)90043-6  1
1981 Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities III: Carboxypeptidase A hydrolysis of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1307-1309. PMID 7320841  1
1981 Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities II: α-chymotrypsin hydrolysis of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1304-1306. PMID 7320840  1
1981 Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities I: Rationale, synthesis, and pharmaceutical properties of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1299-1303. PMID 7320839  1
1981 Amidon GL, Taylor J, Sorkness R. A convective diffusion model for estimating drug loss to tubing: sorption of vitamin A Journal of Parenteral Science and Technology. 35: 13-17. PMID 7229825  1
1981 Amidon GL, Buckner CK. On the use of a dynamic approach to the estimation of dissociation constants for reversible competitive antagonists Journal of Pharmacology and Experimental Therapeutics. 216: 352-356. PMID 6257889  1
1980 Amidon GL, Kou J, Elliott RL, Lightfoot EN. Analysis of models for determining intestinal wall permeabilities. Journal of Pharmaceutical Sciences. 69: 1369-73. PMID 7463318  1
1980 Elliott RL, Amidon GL, Lightfoot EN. A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tube. Journal of Theoretical Biology. 87: 757-71. PMID 7253676 DOI: 10.1016/0022-5193(80)90115-0  1
1980 Amidon GL, Leesman GD, Elliott RL. Improving intestinal absorption of water-insoluble compounds: A membrane metabolism strategy Journal of Pharmaceutical Sciences. 69: 1363-1368. PMID 6780682  1
1980 Amidon GL, Anik ST. Hydrophobicity of polycyclic aromatic compounds. Thermodynamic partitioning analysis The Journal of Physical Chemistry. 84: 970-974.  1
1979 Amidon GL, Pearlman RS, Anik ST. The solvent contribution to the free energy of protein-ligand interactions Journal of Theoretical Biology. 77: 161-170. PMID 449367 DOI: 10.1016/0022-5193(79)90145-0  1
1977 Welling PG, Lyons LL, Elliott R, Amidon GL. Pharmacokinetics of alcohol following single low doses to fasted and nonfasted subjects Journal of Clinical Pharmacology. 17: 199-206. PMID 849994  1
1976 Yalkowsky SH, Valvani SC, Amidon GL. Solubility of nonelectrolytes in polar solvents. IV. Nonpolar drugs in mixed solvents Journal of Pharmaceutical Sciences. 65: 1488-1494. PMID 978408  1
1976 Amidon GL, Anik ST. Comparison of several molecular topological indexes with molecular surface area in aqueous solubility estimation Journal of Pharmaceutical Sciences. 65: 801-806. PMID 932962  1
1976 Amidon GL, Buckner CK. Analysis of models for estimation of beta adrenergic drug parameters using functional and competitive antagonists Federation Proceedings. 35.  1
1976 Valvani SC, Yalkowsky SH, Amidon GL. Solubility of nonelectrolytes in polar solvents. VI. Refinements in molecular surface area computations Journal of Physical Chemistry. 80: 829-835.  1
1975 Yalkowsky SH, Amidon GL, Zografi G, Flynn GL. Solubility of nonelectrolytes in polar solvents. III: Alkyl p aminobenzoates in polar and mixed solvents Journal of Pharmaceutical Sciences. 64: 48-52. PMID 1133705 DOI: 10.1002/jps.2600640109  1
1975 Amidon GL, Paul MJ, Welling PG. Model-independent prediction methods in pharmacokenetics: Theoretical Considerations Mathematical Biosciences. 25: 259-272. DOI: 10.1016/0025-5564(75)90006-1  1
1975 Buckner CK, Saini R, Amidon GL. Estimation of dissociation constants (K(A)) for beta adrenergic agonists Federation Proceedings. 34.  1
1974 Amidon GL. Theoretical calculations on an acetic acid, 5-methylimidazole, methanol hydrogen bond network: A model charge relay system Journal of Theoretical Biology. 46: 101-109. PMID 4855179 DOI: 10.1016/0022-5193(74)90141-6  1
1974 Welling PG, Craig WA, Gordon AL, Kunin CM. Pharmacokinetics of cefazolin in normal and uremic subjects. Clinical Pharmacology and Therapeutics. 15: 344-53. PMID 4821438  1
1974 Amidon GL, Yalkowsky SH, Leung S. Solubility of nonelectrolytes in polar solvents II: Solubility of aliphatic alcohols in water Journal of Pharmaceutical Sciences. 63: 1858-1866. PMID 4449016 DOI: 10.1002/jps.2600610643  1
1974 Amidon GL. Structure and reactivity of theobrominate and theophyllinate complexes with methyl trans cinnamate Journal of Pharmaceutical Sciences. 63: 1524-1526. PMID 4436781  1
1974 Amidon GL. Comparison of theoretical, absolute interaction energies with heats of complexation in carbon tetrachloride Journal of Pharmaceutical Sciences. 63: 1514-1519. PMID 4436779  1
1973 Welling PG, Craig WA, Amidon GL, Kunin CM. Pharmacokinetics of trimethoprim and sulfamethoxazole in normal subjects and in patients with renal failure. The Journal of Infectious Diseases. 128: Suppl:556-66 p. PMID 4758046  1
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