| Year |
Citation |
Score |
| 2024 |
Sammons RM, Devkota AK, Kaoud TS, Warthaka M, Cho EJ, Dalby KN. Steady State and Time-Dependent Fluorescent Peptide Assays for Protein Kinases. Current Protocols. 4: e998. PMID 38439594 DOI: 10.1002/cpz1.998 |
0.392 |
|
| 2024 |
Wible DJ, Parikh Z, Cho EJ, Chen MD, Jeter CR, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Cell Death & Disease. 15: 80. PMID 38253602 DOI: 10.1038/s41419-024-06423-0 |
0.311 |
|
| 2023 |
Piserchio A, Dalby KN, Ghose R. Revealing eEF-2 kinase: recent structural insights into function. Trends in Biochemical Sciences. PMID 38103971 DOI: 10.1016/j.tibs.2023.11.004 |
0.626 |
|
| 2023 |
Lee J, Guo HF, Wang S, Maghsoud Y, Vázquez-Montelongo EA, Jing Z, Sammons RM, Cho EJ, Ren P, Cisneros GA, Kurie JM, Dalby KN. Unleashing the Potential of 1,3-Diketone Analogues as Selective LH2 Inhibitors. Acs Medicinal Chemistry Letters. 14: 1396-1403. PMID 37849534 DOI: 10.1021/acsmedchemlett.3c00305 |
0.63 |
|
| 2023 |
Postiglione AE, Adams LL, Ekhator ES, Odelade AE, Patwardhan S, Chaudhari M, Pardue AS, Kumari A, LeFever WA, Tornow OP, Kaoud TS, Neiswinger J, Jeong JS, Parsonage D, Nelson KJ, ... ... Dalby KN, et al. Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection. Iscience. 26: 107817. PMID 37744034 DOI: 10.1016/j.isci.2023.107817 |
0.688 |
|
| 2023 |
Zhan X, Kaoud TS, Dalby KN, Gurevich EV, Gurevich VV. Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs). Current Protocols. 3: e839. PMID 37668419 DOI: 10.1002/cpz1.839 |
0.705 |
|
| 2023 |
Xie X, Chauhan GB, Edupuganti R, Kogawa T, Park J, Tacam M, Tan AW, Mughees M, Vidhu F, Liu DD, Taliaferro JM, Pitner MK, Browning LS, Lee JH, Shen Y, ... ... Dalby KN, et al. Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer. Cancer Research Communications. 3: 1078-1092. PMID 37377604 DOI: 10.1158/2767-9764.CRC-22-0330 |
0.788 |
|
| 2023 |
Piserchio A, Isiorho EA, Dalby KN, Ghose R. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. The Journal of Biological Chemistry. 104813. PMID 37172726 DOI: 10.1016/j.jbc.2023.104813 |
0.623 |
|
| 2023 |
Piserchio A, Long KJ, Browning LS, Bohanon AL, Isiorho EA, Dalby KN, Ghose R. ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300902120. PMID 37068230 DOI: 10.1073/pnas.2300902120 |
0.834 |
|
| 2023 |
Wible DJ, Parikh Z, Cho EJ, Chen MD, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Biorxiv : the Preprint Server For Biology. PMID 36993747 DOI: 10.1101/2023.03.13.532495 |
0.488 |
|
| 2023 |
Silva RP, Huang Y, Nguyen AW, Hsieh CL, Olaluwoye OS, Kaoud TS, Wilen RE, Qerqez AN, Park JG, Khalil AM, Azouz LR, Le KC, Bohanon AL, DiVenere AM, Liu Y, ... ... Dalby KN, et al. Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses. Elife. 12. PMID 36942851 DOI: 10.7554/eLife.83710 |
0.777 |
|
| 2023 |
Maghsoud Y, Vázquez-Montelongo EA, Yang X, Liu C, Jing Z, Lee J, Harger M, Smith AK, Espinoza M, Guo HF, Kurie JM, Dalby KN, Ren P, Cisneros GA. Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition. Journal of Chemical Information and Modeling. 63: 986-1001. PMID 36779232 DOI: 10.1021/acs.jcim.2c01448 |
0.796 |
|
| 2022 |
Sammons RM, Bohanon AL, Kowtha A, Dejong A, Cho EJ, Kaoud TS, Dalby KN. High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2. Acs Infectious Diseases. 8: 2259-2270. PMID 36315931 DOI: 10.1021/acsinfecdis.2c00297 |
0.792 |
|
| 2022 |
Li Y, Fan Y, Xu J, Huo L, Scott AW, Jin J, Yang B, Shao S, Ma L, Wang Y, Yao X, Pool Pizzi M, Sewastjanow Da Silva M, Zhang G, Zhuo L, ... ... Dalby KN, et al. GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma. Journal of Experimental & Clinical Cancer Research : Cr. 41: 257. PMID 35996148 DOI: 10.1186/s13046-022-02463-6 |
0.398 |
|
| 2022 |
Soleimani M, Somma A, Kaoud TS, Goyal R, Bustamante J, Wylie DC, Holay N, Looney AP, Giri U, Triplett T, Dalby KN, Kowalski J, Eckhardt SG, Van Den Berg C. Covalent JNK inhibitor, JNK-IN-8, suppresses tumor growth in triple-negative breast cancer by activating TFEB and TFE3 mediated lysosome biogenesis and autophagy. Molecular Cancer Therapeutics. PMID 35977156 DOI: 10.1158/1535-7163.MCT-21-1044 |
0.685 |
|
| 2022 |
Perry-Hauser NA, Kaoud TS, Stoy H, Zhan X, Chen Q, Dalby KN, Iverson TM, Gurevich VV, Gurevich EV. Short Arrestin-3-Derived Peptides Activate JNK3 in Cells. International Journal of Molecular Sciences. 23. PMID 35955810 DOI: 10.3390/ijms23158679 |
0.691 |
|
| 2022 |
Piserchio A, Isiorho EA, Long K, Bohanon AL, Kumar EA, Will N, Jeruzalmi D, Dalby KN, Ghose R. Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase. Science Advances. 8: eabo2039. PMID 35857468 DOI: 10.1126/sciadv.abo2039 |
0.841 |
|
| 2022 |
Paul A, Kumar S, Kaoud TS, Pickett MR, Bohanon AL, Zoldan J, Dalby KN, Parekh SH. Biomechanical Dependence of SARS-CoV-2 Infections. Acs Applied Bio Materials. PMID 35486915 DOI: 10.1021/acsabm.2c00143 |
0.761 |
|
| 2022 |
Thomas PW, Cho EJ, Bethel CR, Smisek T, Ahn YC, Schroeder JM, Thomas CA, Dalby KN, Beckham JT, Crowder MW, Bonomo RA, Fast W. Discovery of an Effective Small-Molecule Allosteric Inhibitor of New Delhi Metallo-β-lactamase (NDM). Acs Infectious Diseases. PMID 35353502 DOI: 10.1021/acsinfecdis.1c00577 |
0.436 |
|
| 2022 |
Zeng L, Kaoud TS, Zamora-Olivares D, Bohanon AL, Li Y, Pridgen JR, Ekpo YE, Zhuang DL, Nye JR, Telles M, Winkler M, Rivera S, Marini F, Dalby KN, Anslyn EV. Multiplexing the Quantitation of MAP Kinase Activities Using Differential Sensing. Journal of the American Chemical Society. 144: 4017-4025. PMID 35195411 DOI: 10.1021/jacs.1c12757 |
0.828 |
|
| 2022 |
Scheele RA, Lindenburg LH, Petek M, Schober M, Dalby KN, Hollfelder F. Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates. Nature Communications. 13: 844. PMID 35149678 DOI: 10.1038/s41467-022-28396-4 |
0.741 |
|
| 2022 |
Perry-Hauser NA, Bennett Hopkins J, Zhuo Y, Zheng C, Perez I, Schultz KM, Vishnivetskiy SA, Kaya AI, Sharma P, Dalby KN, Young Chung K, Klug CS, Gurevich VV, Iverson TM. The two non-visual arrestins engage ERK2 differently. Journal of Molecular Biology. 167465. PMID 35077767 DOI: 10.1016/j.jmb.2022.167465 |
0.312 |
|
| 2021 |
Javanmardi K, Chou CW, Terrace CI, Annapareddy A, Kaoud TS, Guo Q, Lutgens J, Zorkic H, Horton AP, Gardner EC, Nguyen G, Boutz DR, Goike J, Voss WN, Kuo HC, ... Dalby KN, et al. Rapid characterization of spike variants via mammalian cell surface display. Molecular Cell. 81: 5099-5111.e8. PMID 34919820 DOI: 10.1016/j.molcel.2021.11.024 |
0.589 |
|
| 2021 |
Ramadan M, A M M Elshaier Y, Aly AA, Abdel-Aziz M, Fathy HM, Brown AB, Pridgen JR, Dalby KN, Kaoud TS. Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. Bioorganic Chemistry. 116: 105344. PMID 34598088 DOI: 10.1016/j.bioorg.2021.105344 |
0.711 |
|
| 2021 |
Cho EJ, Dalby KN. Luminescence Energy Transfer-Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery. Slas Discovery : Advancing Life Sciences R & D. 24725552211036056. PMID 34330171 DOI: 10.1177/24725552211036056 |
0.39 |
|
| 2021 |
Piserchio A, Long K, Lee K, Kumar EA, Abzalimov R, Dalby KN, Ghose R. Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation. Protein Science : a Publication of the Protein Society. PMID 33890716 DOI: 10.1002/pro.4087 |
0.834 |
|
| 2021 |
Guo HF, Bota-Rabassedas N, Terajima M, Leticia Rodriguez B, Gibbons DL, Chen Y, Banerjee P, Tsai CL, Tan X, Liu X, Yu J, Tokmina-Roszyk M, Stawikowska R, Fields GB, Miller MD, ... ... Dalby KN, et al. A collagen glucosyltransferase drives lung adenocarcinoma progression in mice. Communications Biology. 4: 482. PMID 33875777 DOI: 10.1038/s42003-021-01982-w |
0.573 |
|
| 2021 |
Mohiuddin IS, Wei SJ, Yang IH, Martinez GM, Yang S, Cho EJ, Dalby KN, Kang MH. Development of Cell-based High Throughput Luminescence Assay for Drug Discovery in Inhibiting OCT4-DNA-PKcs and OCT4-MK2 Interactions. Biotechnology and Bioengineering. PMID 33565603 DOI: 10.1002/bit.27712 |
0.511 |
|
| 2020 |
Cho EJ, Devkota AK, Stancu G, Edupunganti R, Debevec G, Giulianotti M, Houghten R, Powis G, Dalby KN. A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A. Slas Discovery : Advancing Life Sciences R & D. 2472555220926146. PMID 32462959 DOI: 10.1177/2472555220926146 |
0.796 |
|
| 2020 |
Gagliardi M, Pitner MK, Park J, Xie X, Saso H, Larson RA, Sammons RM, Chen H, Wei C, Masuda H, Chauhan G, Kondo K, Tripathy D, Ueno NT, Dalby KN, et al. Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer. Scientific Reports. 10: 8537. PMID 32444778 DOI: 10.1038/S41598-020-65250-3 |
0.77 |
|
| 2020 |
Semba T, Sammons R, Wang X, Xie X, Dalby KN, Ueno NT. JNK Signaling in Stem Cell Self-Renewal and Differentiation. International Journal of Molecular Sciences. 21. PMID 32283767 DOI: 10.3390/Ijms21072613 |
0.721 |
|
| 2020 |
Crittenden CM, Novelli ET, Xu G, Giles DH, Fies WA, Mehaffey MR, Dalby KN, Webb LJ, Brodbelt JS. Structural Evaluation of Protein/Metal Complexes via Native Electrospray Ultraviolet Photodissociation Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 32275426 DOI: 10.1021/Jasms.0C00066 |
0.596 |
|
| 2020 |
Del Mundo IMA, Cho EJ, Dalby KN, Vasquez KM. A 'light-up' intercalator displacement assay for detection of triplex DNA stabilizers. Chemical Communications (Cambridge, England). PMID 31960843 DOI: 10.1039/C9Cc08817B |
0.352 |
|
| 2020 |
Kumar EA, Giles D, Dalby K. AMPK can stimulate eEF2 phosphorylation without regulating its cognate kinase eEF2K The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09697 |
0.695 |
|
| 2019 |
Kaoud TS, Mohassab AM, Hassan HA, Yan C, Van Ravenstein SX, Abdelhamid D, Dalby KN, Abdel-Aziz M. NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth. European Journal of Medicinal Chemistry. 111885. PMID 31784187 DOI: 10.1016/j.ejmech.2019.111885 |
0.657 |
|
| 2019 |
Zamora-Olivares D, Kaoud TS, Zeng L, Pridgen JR, Zhuang DL, Ekpo YE, Nye JR, Telles M, Anslyn EV, Dalby KN. Quantification of ERK kinase activity in biological samples using differential sensing. Acs Chemical Biology. PMID 31775004 DOI: 10.1021/Acschembio.9B00580 |
0.756 |
|
| 2019 |
Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, ... ... Dalby KN, et al. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nature Communications. 10: 5232. PMID 31745079 DOI: 10.1038/S41467-019-12996-8 |
0.816 |
|
| 2019 |
Lee K, Kumar EA, Dalby KN, Ghose R. The Role of Calcium in the Interaction between Calmodulin and a Minimal Functional Construct of Eukaryotic Elongation Factor 2 Kinase. Protein Science : a Publication of the Protein Society. PMID 31626716 DOI: 10.1002/Pro.3753 |
0.821 |
|
| 2019 |
Perry NA, Fialkowski KP, Kaoud TS, Kaya AI, Chen AL, Taliaferro JM, Gurevich VV, Dalby KN, Iverson TM. Arrestin-3 interaction with maternal embryonic leucine-zipper kinase. Cellular Signalling. 109366. PMID 31352007 DOI: 10.1016/J.Cellsig.2019.109366 |
0.816 |
|
| 2019 |
Qi R, Walker B, Jing Z, Yu M, Stancu G, Edupuganti R, Dalby KN, Ren P. Computational and Experimental Studies of Inhibitor Design for Aldolase A. The Journal of Physical Chemistry. B. PMID 31268712 DOI: 10.1021/Acs.Jpcb.9B04551 |
0.679 |
|
| 2019 |
Sammons RM, Ghose R, Tsai KY, Dalby KN. Targeting ERK beyond the boundaries of the kinase active site in melanoma. Molecular Carcinogenesis. PMID 31190430 DOI: 10.1002/Mc.23047 |
0.805 |
|
| 2019 |
Piserchio A, Will N, Giles DH, Hajredini F, Dalby KN, Ghose R. Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and its Role in Substrate Recognition. Journal of Molecular Biology. PMID 31108082 DOI: 10.1016/J.Jmb.2019.05.019 |
0.75 |
|
| 2019 |
Harger M, Lee JH, Walker B, Taliaferro JM, Edupuganti R, Dalby KN, Ren P. Computational insights into the binding of IN17 inhibitors to MELK. Journal of Molecular Modeling. 25: 151. PMID 31069524 DOI: 10.1007/S00894-019-4036-1 |
0.818 |
|
| 2019 |
Du L, Anderson A, Nguyen K, Ojeda SS, Ortiz-Rivera I, Nguyen TN, Zhang T, Kaoud TS, Gray NS, Dalby KN, Tsai KY. JNK2 is required for tumorigenic properties of melanoma cells. Acs Chemical Biology. PMID 31063355 DOI: 10.1021/acschembio.9b00083 |
0.677 |
|
| 2019 |
Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. Acs Chemical Biology. PMID 31058487 DOI: 10.1021/Acschembio.9B00093 |
0.856 |
|
| 2019 |
Veloria J, Shin M, Devkota AK, Payne SM, Cho EJ, Dalby KN. Developing Colorimetric and Luminescence-Based High-Throughput Screening Platforms for Monitoring the GTPase Activity of Ferrous Iron Transport Protein B (FeoB). Slas Discovery : Advancing Life Sciences R & D. 2472555219844572. PMID 31039677 DOI: 10.1177/2472555219844572 |
0.744 |
|
| 2019 |
Del Mundo IMA, Cho EJ, Dalby KN, Vasquez KM. A tunable assay for modulators of genome-destabilizing DNA structures. Nucleic Acids Research. PMID 30949695 DOI: 10.1093/Nar/Gkz237 |
0.341 |
|
| 2019 |
Hassan AA, Aly AA, Mohamed NK, El Shaieb KM, Makhlouf MM, Abdelhafez EMN, Bräse S, Nieger M, Dalby KN, Kaoud TS. Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3]propellane derivatives: Potential anticancer agents. Bioorganic Chemistry. 85: 585-599. PMID 30878891 DOI: 10.1016/J.Bioorg.2019.02.027 |
0.599 |
|
| 2018 |
Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Proceedings of the National Academy of Sciences of the United States of America. PMID 30591558 DOI: 10.1073/Pnas.1819230116 |
0.694 |
|
| 2018 |
Devkota AK, Veloria JR, Guo HF, Kurie JM, Cho EJ, Dalby KN. Development of a High-Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small-Molecule Inhibitors against LH2. Slas Discovery : Advancing Life Sciences R & D. 2472555218817057. PMID 30589612 DOI: 10.1177/2472555218817057 |
0.753 |
|
| 2018 |
Aly AA, El-Sheref EM, Bakheet MEM, Mourad MAE, Bräse S, Ibrahim MAA, Nieger M, Garvalov BK, Dalby KN, Kaoud TS. Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma. Bioorganic Chemistry. 82: 290-305. PMID 30396063 DOI: 10.1016/J.Bioorg.2018.10.044 |
0.688 |
|
| 2018 |
Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, et al. Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe-binding. Nature Communications. 9: 2719. PMID 29988035 DOI: 10.1038/S41467-018-05295-1 |
0.567 |
|
| 2018 |
Will N, Lee K, Hajredini F, Giles DH, Abzalimov RR, Clarkson M, Dalby KN, Ghose R. Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca-Calmodulin. Journal of Molecular Biology. PMID 29800565 DOI: 10.1016/J.Jmb.2018.05.033 |
0.771 |
|
| 2018 |
Veloria JR, Devkota AK, Cho EJ, Dalby KN. Development of a cost effective and robust AlphaScreen platform for application. Biotechniques. 64: 181-183. PMID 29661010 DOI: 10.2144/Btn-2018-2001 |
0.715 |
|
| 2018 |
Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, et al. Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nature Communications. 9: 512. PMID 29410444 DOI: 10.1038/S41467-018-02859-Z |
0.625 |
|
| 2018 |
Xie X, Otsuka S, Chu K, Lu A, Tripathy D, Dalby K, Hittelman W, Laere SV, Bartholomeusz C, Ueno N. Abstract P1-05-03: JNK signaling regulates tumor cell–tumor-associated macrophage cross-talk in triple-negative breast cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P1-05-03 |
0.37 |
|
| 2017 |
Ebelt ND, Kaoud TS, Edupuganti R, Van Ravenstein S, Dalby KN, Van Den Berg CL. A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib. Oncotarget. 8: 104894-104912. PMID 29285221 DOI: 10.18632/oncotarget.20581 |
0.657 |
|
| 2017 |
Jose J, Tavares CDJ, Ebelt ND, Lodi A, Edupuganti R, Xie X, Devkota AK, Kaoud TS, Van Den Berg CL, Anslyn EV, Tiziani S, Bartholomeusz C, Dalby KN. Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth. Acs Medicinal Chemistry Letters. 8: 1072-1076. PMID 29057053 DOI: 10.1021/Acsmedchemlett.7B00282 |
0.784 |
|
| 2017 |
Mohassab AM, Hassan HA, Abdelhamid D, Abdel-Aziz M, Dalby KN, Kaoud TS. Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations. Bioorganic Chemistry. 75: 242-259. PMID 29032325 DOI: 10.1016/j.bioorg.2017.09.018 |
0.596 |
|
| 2017 |
Cho EJ, Devkota AK, Stancu G, Edupunganti R, Powis G, Dalby KN. A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase. Slas Discovery. 2472555217726325. PMID 28820953 DOI: 10.1177/2472555217726325 |
0.787 |
|
| 2017 |
Pitner MK, Taliaferro JM, Dalby KN, Bartholomeusz C. MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies. Expert Opinion On Therapeutic Targets. 1-11. PMID 28764577 DOI: 10.1080/14728222.2017.1363183 |
0.683 |
|
| 2017 |
Piserchio A, Warthaka M, Kaoud TS, Callaway K, Dalby KN, Ghose R. Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716922 DOI: 10.1073/Pnas.1702973114 |
0.832 |
|
| 2017 |
Harger M, Li D, Wang Z, Dalby K, Lagardère L, Piquemal JP, Ponder J, Ren P. Tinker-OpenMM: Absolute and relative alchemical free energies using AMOEBA on GPUs. Journal of Computational Chemistry. 38: 2047-2055. PMID 28600826 DOI: 10.1002/Jcc.24853 |
0.776 |
|
| 2017 |
Edupuganti R, Taliaferro JM, Wang Q, Xie X, Cho EJ, Vidhu F, Ren P, Anslyn EV, Bartholomeusz C, Dalby KN. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorganic & Medicinal Chemistry. PMID 28351607 DOI: 10.1016/J.Bmc.2017.03.018 |
0.817 |
|
| 2017 |
Guo HF, Cho EJ, Devkota AK, Chen Y, Russell W, Phillips GN, Yamauchi M, Dalby KN, Kurie JM. A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay. Archives of Biochemistry and Biophysics. PMID 28216326 DOI: 10.1016/J.Abb.2017.02.003 |
0.749 |
|
| 2017 |
Guo H, Tsai C, Chen Y, Terajima M, Yamauchi M, Alvarado S, Cho E, Dalby K, Phillips G, Tainer J, Kurie J. Structure-Based Drug Design Targeting a Pro-Metastatic Collagen Lysyl Hydroxylase Journal of Thoracic Oncology. 12: S1543. DOI: 10.1016/J.Jtho.2017.06.048 |
0.415 |
|
| 2016 |
Tavares CD, Giles DH, Stancu G, Chitjian CA, Ferguson SB, Wellmann RM, Kaoud TS, Ghose R, Dalby KN. Signal Integration at Elongation Factor 2 Kinase; the Roles of Calcium, Calmodulin and Ser-500 Phosphorylation. The Journal of Biological Chemistry. PMID 27956550 DOI: 10.1074/Jbc.M116.753277 |
0.82 |
|
| 2016 |
Xie X, Kaoud TS, Edupuganti R, Zhang T, Kogawa T, Zhao Y, Chauhan GB, Giannoukos DN, Qi Y, Tripathy D, Wang J, Gray NS, Dalby KN, Bartholomeusz C, Ueno NT. c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun. Oncogene. PMID 27941886 DOI: 10.1038/onc.2016.417 |
0.658 |
|
| 2016 |
Veloria JR, Devkota AK, Cho EJ, Dalby KN. Optimization of a Luminescence-Based High-Throughput Screening Assay for Detecting Apyrase Activity. Journal of Biomolecular Screening. PMID 27821623 DOI: 10.1177/1087057116675859 |
0.746 |
|
| 2016 |
Will N, Piserchio A, Snyder I, Ferguson SB, Giles DH, Dalby KN, Ghose R. Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase. Biochemistry. PMID 27571275 DOI: 10.1021/Acs.Biochem.6B00711 |
0.828 |
|
| 2016 |
Lee K, Alphonse S, Piserchio A, Tavares CD, Giles DH, Wellmann RM, Dalby KN, Ghose R. Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin. Structure (London, England : 1993). PMID 27499441 DOI: 10.1016/J.Str.2016.06.015 |
0.835 |
|
| 2016 |
Robinson MR, Taliaferro JM, Dalby KN, Brodbelt JS. 193 nm Ultraviolet Photodissociation Mass Spectrometry for Phosphopeptide Characterization in the Positive and Negative Ion Modes. Journal of Proteome Research. PMID 27425180 DOI: 10.1021/Acs.Jproteome.6B00289 |
0.645 |
|
| 2016 |
Grandjean G, De Jong PR, James BP, Koh MY, Lemos R, Kingston J, Aleshin A, Bankston LA, Miller CP, Cho EJ, Edupuganti R, Devkota A, Stancu G, Liddington RC, Dalby KN, et al. Definition of a novel feed-forward mechanism for glycolysis-HIF1α signaling in hypoxic tumors highlights adolase A as a therapeutic target. Cancer Research. PMID 27261507 DOI: 10.1158/0008-5472.Can-16-0401 |
0.807 |
|
| 2016 |
Rycaj K, Cho EJ, Liu X, Chao HP, Liu B, Li Q, Devkota AK, Zhang D, Chen X, Moore J, Dalby KN, Tang DG. Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget. PMID 26871947 DOI: 10.18632/Oncotarget.7303 |
0.752 |
|
| 2016 |
Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV. Peptide mini-scaffold facilitates JNK3 activation in cells. Scientific Reports. 6: 21025. PMID 26868142 DOI: 10.1038/Srep21025 |
0.686 |
|
| 2016 |
Tavares CD, Devkota AK, Dalby KN, Cho EJ. Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening. Methods in Molecular Biology (Clifton, N.J.). 1360: 19-33. PMID 26501899 DOI: 10.1007/978-1-4939-3073-9_2 |
0.831 |
|
| 2016 |
Pitner MK, Saso H, Larson R, Sammons RM, Chen H, Wei C, Chauhan G, Kondo K, Ueno NT, Dalby K, Debeb BG, Bartholomeusz C. Abstract 1624: Silencing of ERK2 reverses EMT and suppresses the CSC phenotype, inhibiting lung metastasis in triple-negative breast cancer Cancer Research. 76: 1624-1624. DOI: 10.1158/1538-7445.Am2016-1624 |
0.733 |
|
| 2015 |
Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Scientific Reports. 5: 12369. PMID 26230360 DOI: 10.1038/srep12369 |
0.716 |
|
| 2015 |
Piserchio A, Ramakrishan V, Wang H, Kaoud TS, Arshava B, Dutta K, Dalby KN, Ghose R. Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. Scientific Reports. 5: 11127. PMID 26054059 DOI: 10.1038/Srep11127 |
0.727 |
|
| 2015 |
Wang Q, Edupuganti R, Tavares CD, Dalby KN, Ren P. Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis. Frontiers in Molecular Biosciences. 2: 9. PMID 25988177 DOI: 10.3389/Fmolb.2015.00009 |
0.801 |
|
| 2015 |
Zhan X, Kook S, Kaoud TS, Dalby KN, Gurevich EV, Gurevich VV. Arrestin-3-Dependent Activation of c-Jun N-Terminal Kinases (JNKs). Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 68: 2.12.1-2.12.26. PMID 25737158 DOI: 10.1002/0471141755.Ph0212S68 |
0.714 |
|
| 2015 |
Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. Acs Medicinal Chemistry Letters. 6: 47-52. PMID 25589929 DOI: 10.1021/Ml500198B |
0.804 |
|
| 2015 |
Jo HH, Edupuganti R, You L, Dalby KN, Anslyn EV. Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers. Chemical Science (Royal Society of Chemistry : 2010). 6: 158-164. PMID 25530834 DOI: 10.1039/C4Sc02495H |
0.367 |
|
| 2015 |
Du L, Zhang T, Kaoud T, Gray N, Dalby K, Tsai KY. Abstract 1941: Distinct roles of c-Jun N-terminal kinase (JNK) isoforms in skin cancer Cancer Research. 75: 1941-1941. DOI: 10.1158/1538-7445.Am2015-1941 |
0.705 |
|
| 2015 |
Jo HH, Edupuganti R, You L, Dalby KN, Anslyn EV. Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers Chemical Science. 6: 158-164. DOI: 10.1039/c4sc02495h |
0.358 |
|
| 2014 |
Zamora-Olivares D, Kaoud TS, Jose J, Ellington A, Dalby KN, Anslyn EV. Differential sensing of MAP kinases using SOX-peptides. Angewandte Chemie (International Ed. in English). 53: 14064-8. PMID 25319433 DOI: 10.1002/Anie.201408256 |
0.774 |
|
| 2014 |
Devkota AK, Edupuganti R, Yan C, Shi Y, Jose J, Wang Q, Kaoud TS, Cho EJ, Ren P, Dalby KN. Reversible covalent inhibition of eEF-2K by carbonitriles. Chembiochem : a European Journal of Chemical Biology. 15: 2435-42. PMID 25224652 DOI: 10.1002/Cbic.201402321 |
0.825 |
|
| 2014 |
Radwan MF, Dalby KN, Kaoud TS. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. Acs Medicinal Chemistry Letters. 5: 983-8. PMID 25221653 DOI: 10.1021/ml500156v |
0.591 |
|
| 2014 |
Edupuganti R, Wang Q, Tavares CD, Chitjian CA, Bachman JL, Ren P, Anslyn EV, Dalby KN. Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. Bioorganic & Medicinal Chemistry. 22: 4910-6. PMID 25047940 DOI: 10.1016/J.Bmc.2014.06.050 |
0.8 |
|
| 2014 |
Tavares CD, Ferguson SB, Giles DH, Wang Q, Wellmann RM, O'Brien JP, Warthaka M, Brodbelt JS, Ren P, Dalby KN. The molecular mechanism of eukaryotic elongation factor 2 kinase activation. The Journal of Biological Chemistry. 289: 23901-16. PMID 25012662 DOI: 10.1074/Jbc.M114.577148 |
0.828 |
|
| 2014 |
Wang Q, Park J, Devkota AK, Cho EJ, Dalby KN, Ren P. Identification and validation of novel PERK inhibitors. Journal of Chemical Information and Modeling. 54: 1467-75. PMID 24745945 DOI: 10.1021/Ci500114R |
0.803 |
|
| 2014 |
Mu X, Wang Q, Wang LP, Fried SD, Piquemal JP, Dalby KN, Ren P. Modeling organochlorine compounds and the σ-hole effect using a polarizable multipole force field. The Journal of Physical Chemistry. B. 118: 6456-65. PMID 24484473 DOI: 10.1021/Jp411671A |
0.596 |
|
| 2014 |
Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. High-throughput screens for eEF-2 kinase. Journal of Biomolecular Screening. 19: 445-52. PMID 24078616 DOI: 10.1177/1087057113505204 |
0.827 |
|
| 2014 |
Zamora-Olivares D, Kaoud TS, Jose J, Ellington A, Dalby KN, Anslyn EV. Differential sensing of MAP kinases using SOX-peptides Angewandte Chemie - International Edition. 53: 14064-14068. DOI: 10.1002/anie.201408256 |
0.7 |
|
| 2013 |
Kook S, Zhan X, Kaoud TS, Dalby KN, Gurevich VV, Gurevich EV. Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding. The Journal of Biological Chemistry. 288: 37332-42. PMID 24257757 DOI: 10.1074/Jbc.M113.510412 |
0.719 |
|
| 2013 |
Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, ... ... Dalby KN, et al. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling. Elife. 2: e00969. PMID 24192036 DOI: 10.7554/Elife.00969 |
0.76 |
|
| 2013 |
Dykstra DW, Dalby KN, Ren P. Elucidating binding modes of zuonin A enantiomers to JNK1 via in silico methods. Journal of Molecular Graphics & Modelling. 45: 38-44. PMID 24001752 DOI: 10.1016/J.Jmgm.2013.08.008 |
0.346 |
|
| 2013 |
Zamora-Olivares D, Kaoud TS, Dalby KN, Anslyn EV. In-situ generation of differential sensors that fingerprint kinases and the cellular response to their expression Journal of the American Chemical Society. 135: 14814-14820. PMID 23991633 DOI: 10.1021/Ja407397Z |
0.759 |
|
| 2013 |
Zhan X, Kaoud TS, Kook S, Dalby KN, Gurevich VV. JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases. The Journal of Biological Chemistry. 288: 28535-47. PMID 23960075 DOI: 10.1074/Jbc.M113.508085 |
0.725 |
|
| 2013 |
Madsen JA, Xu H, Robinson MR, Horton AP, Shaw JB, Giles DK, Kaoud TS, Dalby KN, Trent MS, Brodbelt JS. High-throughput database search and large-scale negative polarity liquid chromatography-tandem mass spectrometry with ultraviolet photodissociation for complex proteomic samples. Molecular & Cellular Proteomics : McP. 12: 2604-14. PMID 23695934 DOI: 10.1074/Mcp.O113.028258 |
0.731 |
|
| 2013 |
Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Dalby KN, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/Msb.2013.12 |
0.369 |
|
| 2013 |
Li J, Kaoud TS, Levieux J, Gilbreath B, Moharana S, Dalby KN, Kerwin SM. A Fluorescence-Based Assay for p38α Recruitment Site Binders: Identification of Rooperol as a Novel p38α Kinase Inhibitor Chembiochem. 14: 66-71. PMID 23225637 DOI: 10.1002/Cbic.201200529 |
0.644 |
|
| 2013 |
Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, ... ... Dalby KN, et al. BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling Elife. 2013. DOI: 10.7554/eLife.00969.001 |
0.76 |
|
| 2013 |
Ashour AA, Abdel-Aziz AH, Mansour AM, Alpay SN, Dalby K, Ozpolat B. Abstract 848: Inhibition of eukaryotic elongation factor-2 kinase mediates Rottlerin induced effects in apoptosis and cell proliferation inhibition in human pancreatic cancer cells. Cancer Research. 73: 848-848. DOI: 10.1158/1538-7445.Am2013-848 |
0.451 |
|
| 2012 |
Piserchio A, Francis DM, Koveal D, Dalby KN, Page R, Peti W, Ghose R. Docking interactions of hematopoietic tyrosine phosphatase with MAP kinases ERK2 and p38α. Biochemistry. 51: 8047-9. PMID 23030599 DOI: 10.1021/Bi3012725 |
0.6 |
|
| 2012 |
Kaoud TS, Yan C, Mitra S, Tseng CC, Jose J, Taliaferro JM, Tuohetahuntila M, Devkota A, Sammons R, Park J, Park H, Shi Y, Hong J, Ren P, Dalby KN. From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. Acs Medicinal Chemistry Letters. 3: 721-725. PMID 23002419 DOI: 10.1021/Ml300129B |
0.824 |
|
| 2012 |
Kaoud TS, Park H, Mitra S, Yan C, Tseng CC, Shi Y, Jose J, Taliaferro JM, Lee K, Ren P, Hong J, Dalby KN. Manipulating JNK signaling with (--)-zuonin A. Acs Chemical Biology. 7: 1873-83. PMID 22916726 DOI: 10.1021/Cb300261E |
0.846 |
|
| 2012 |
Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B. Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. Plos One. 7: e41171. PMID 22911754 DOI: 10.1371/Journal.Pone.0041171 |
0.824 |
|
| 2012 |
Madsen JA, Cheng RR, Kaoud TS, Dalby KN, Makarov DE, Brodbelt JS. Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 5374-83. PMID 22431222 DOI: 10.1002/Chem.201103534 |
0.621 |
|
| 2012 |
Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry. 51: 2100-12. PMID 22352903 DOI: 10.1021/Bi201787P |
0.836 |
|
| 2012 |
Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. Biochemistry. 51: 2232-45. PMID 22329831 DOI: 10.1021/Bi201788E |
0.819 |
|
| 2012 |
Schnieders MJ, Kaoud TS, Yan C, Dalby KN, Ren P. Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinases. Current Pharmaceutical Design. 18: 1173-85. PMID 22316156 DOI: 10.2174/138920012799362873 |
0.701 |
|
| 2012 |
Piserchio A, Dalby KN, Ghose R. Assignment of backbone resonances in a eukaryotic protein kinase - ERK2 as a representative example. Methods in Molecular Biology (Clifton, N.J.). 831: 359-68. PMID 22167683 DOI: 10.1007/978-1-61779-480-3_19 |
0.534 |
|
| 2012 |
Kaoud TS, Yan C, Tseng C, Jose J, Devkota AK, Taliaferro J, Ren P, Dalby K. Abstract 4776: From in-silico screening to anti-cancer activity: The discovery of a potent inhibitor targeting the JNK-JIP interaction Cancer Research. 72: 4776-4776. DOI: 10.1158/1538-7445.Am2012-4776 |
0.834 |
|
| 2012 |
Abramczyk O, Tavares CDJ, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Corrigendum to "Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli" [Protein Expression and Purification 79 (2011) 237-244] (DOI:10.1016/j.pep.2011.05.005) Protein Expression and Purification. DOI: 10.1016/J.Pep.2012.07.010 |
0.806 |
|
| 2011 |
Coffa S, Breitman M, Hanson SM, Callaway K, Kook S, Dalby KN, Gurevich VV. The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation. Plos One. 6: e28723. PMID 22174878 DOI: 10.1371/Journal.Pone.0028723 |
0.776 |
|
| 2011 |
Zhan X, Kaoud TS, Dalby KN, Gurevich VV. Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex. Biochemistry. 50: 10520-9. PMID 22047447 DOI: 10.1021/Bi201506G |
0.723 |
|
| 2011 |
Lee S, Warthaka M, Yan C, Kaoud TS, Ren P, Dalby KN. Examining docking interactions on ERK2 with modular peptide substrates. Biochemistry. 50: 9500-10. PMID 21955038 DOI: 10.1021/Bi201103B |
0.827 |
|
| 2011 |
Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli. Protein Expression and Purification. 79: 237-44. PMID 21605678 DOI: 10.1016/J.Pep.2011.05.005 |
0.833 |
|
| 2011 |
Kaoud TS, Devkota AK, Harris R, Rana MS, Abramczyk O, Warthaka M, Lee S, Girvin ME, Riggs AF, Dalby KN. Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15. Biochemistry. 50: 4568-78. PMID 21506533 DOI: 10.1021/Bi200202Y |
0.794 |
|
| 2011 |
Lee S, Warthaka M, Yan C, Kaoud TS, Piserchio A, Ghose R, Ren P, Dalby KN. A model of a MAPK•substrate complex in an active conformation: a computational and experimental approach. Plos One. 6: e18594. PMID 21494553 DOI: 10.1371/Journal.Pone.0018594 |
0.82 |
|
| 2011 |
Piserchio A, Warthaka M, Devkota AK, Kaoud TS, Lee S, Abramczyk O, Ren P, Dalby KN, Ghose R. Solution NMR insights into docking interactions involving inactive ERK2. Biochemistry. 50: 3660-72. PMID 21449613 DOI: 10.1021/Bi2000559 |
0.817 |
|
| 2011 |
Kaoud TS, Mitra S, Lee S, Taliaferro J, Cantrell M, Linse KD, Van Den Berg CL, Dalby KN. Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration. Acs Chemical Biology. 6: 658-66. PMID 21438496 DOI: 10.1021/Cb200017N |
0.814 |
|
| 2011 |
Madsen JA, Kaoud TS, Dalby KN, Brodbelt JS. 193-nm photodissociation of singly and multiply charged peptide anions for acidic proteome characterization. Proteomics. 11: 1329-34. PMID 21365762 DOI: 10.1002/Pmic.201000565 |
0.6 |
|
| 2011 |
Yan C, Kaoud T, Lee S, Dalby KN, Ren P. Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1. The Journal of Physical Chemistry. B. 115: 1491-502. PMID 21261310 DOI: 10.1021/Jp1073522 |
0.818 |
|
| 2010 |
Devkota AK, Kaoud TS, Warthaka M, Dalby KN. Fluorescent peptide assays for protein kinases. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 18.17. PMID 20583097 DOI: 10.1002/0471142727.Mb1817S91 |
0.832 |
|
| 2010 |
Callaway K, Waas WF, Rainey MA, Ren P, Dalby KN. Phosphorylation of the transcription factor Ets-1 by ERK2: rapid dissociation of ADP and phospho-Ets-1. Biochemistry. 49: 3619-30. PMID 20361728 DOI: 10.1021/Bi100199Q |
0.811 |
|
| 2010 |
Zhang J, King CA, Dalby K, Ren P. Conformational preference of ChaK1 binding peptides: a molecular dynamics study. Pmc Biophysics. 3: 2. PMID 20180991 DOI: 10.1186/1757-5036-3-2 |
0.326 |
|
| 2009 |
Li J, Kaoud TS, Laroche C, Dalby KN, Kerwin SM. Synthesis and biological evaluation of p38α kinase-targeting dialkynylimidazoles Bioorganic and Medicinal Chemistry Letters. 19: 6293-6297. PMID 19822424 DOI: 10.1016/J.Bmcl.2009.09.094 |
0.691 |
|
| 2008 |
Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE. Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. The Journal of Biological Chemistry. 283: 19511-20. PMID 18482985 DOI: 10.1074/Jbc.M801074200 |
0.366 |
|
| 2007 |
Callaway K, Abramczyk O, Martin L, Dalby KN. The anti-apoptotic protein PEA-15 is a tight binding inhibitor of ERK1 and ERK2, which blocks docking interactions at the D-recruitment site. Biochemistry. 46: 9187-98. PMID 17658892 DOI: 10.1021/Bi700206U |
0.845 |
|
| 2007 |
Abramczyk O, Rainey MA, Barnes R, Martin L, Dalby KN. Expanding the repertoire of an ERK2 recruitment site: cysteine footprinting identifies the D-recruitment site as a mediator of Ets-1 binding. Biochemistry. 46: 9174-86. PMID 17658891 DOI: 10.1021/Bi7002058 |
0.812 |
|
| 2007 |
Brahma A, Dalby KN. Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer. Archives of Biochemistry and Biophysics. 460: 85-91. PMID 17254543 DOI: 10.1016/J.Abb.2006.11.031 |
0.832 |
|
| 2007 |
Waas WF, Dalby KN. The expression and purification of the N-terminal activation domain of the transcription factor c-Myc: a model substrate for exploring ERK2 docking interactions. Protein Expression and Purification. 53: 80-6. PMID 17251036 DOI: 10.1016/J.Pep.2006.12.004 |
0.79 |
|
| 2006 |
Callaway KA, Rainey MA, Riggs AF, Abramczyk O, Dalby KN. Properties and regulation of a transiently assembled ERK2.Ets-1 signaling complex. Biochemistry. 45: 13719-33. PMID 17105191 DOI: 10.1021/Bi0610451 |
0.823 |
|
| 2005 |
Callaway K, Rainey MA, Dalby KN. Quantifying ERK2-protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains. Biochimica Et Biophysica Acta. 1754: 316-23. PMID 16324895 DOI: 10.1016/J.Bbapap.2005.11.002 |
0.841 |
|
| 2005 |
Szafranska AE, Dalby KN. Kinetic mechanism for p38 MAP kinase alpha. A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate. The Febs Journal. 272: 4631-45. PMID 16156785 DOI: 10.1111/j.1742-4658.2005.04827.x |
0.357 |
|
| 2005 |
Rainey MA, Callaway K, Barnes R, Wilson B, Dalby KN. Proximity-induced catalysis by the protein kinase ERK2. Journal of the American Chemical Society. 127: 10494-5. PMID 16045329 DOI: 10.1021/Ja052915P |
0.839 |
|
| 2005 |
Szafranska AE, Luo X, Dalby KN. Following in vitro activation of mitogen-activated protein kinases by mass spectrometry and tryptic peptide analysis: purifying fully activated p38 mitogen-activated protein kinase alpha. Analytical Biochemistry. 336: 1-10. PMID 15582552 DOI: 10.1016/J.Ab.2004.09.039 |
0.609 |
|
| 2004 |
Waas WF, Rainey MA, Szafranska AE, Cox K, Dalby KN. A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium. Biochimica Et Biophysica Acta. 1697: 81-7. PMID 15023352 DOI: 10.1016/J.Bbapap.2003.11.015 |
0.844 |
|
| 2004 |
Rainey MA, Linse KD, Dalby KN. Phage display identifies novel peptides that bind extracellular-regulated protein kinase 2 to compete with transcription factor binding Journal of Physical Organic Chemistry. 17: 461-471. DOI: 10.1002/Poc.762 |
0.79 |
|
| 2003 |
Waas WF, Rainey MA, Szafranska AE, Dalby KN. Two rate-limiting steps in the kinetic mechanism of the serine/threonine specific protein kinase ERK2: a case of fast phosphorylation followed by fast product release. Biochemistry. 42: 12273-86. PMID 14567689 DOI: 10.1021/Bi0348617 |
0.844 |
|
| 2003 |
Waas WF, Dalby KN. Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2. Biochemistry. 42: 2960-70. PMID 12627962 DOI: 10.1021/Bi027171W |
0.799 |
|
| 2002 |
Waas WF, Dalby KN. Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2. The Journal of Biological Chemistry. 277: 12532-40. PMID 11812784 DOI: 10.1074/Jbc.M110523200 |
0.817 |
|
| 2002 |
Hanes RE, Lynch VM, Anslyn EV, Dalby KN. Toward a stable hydroxyphosphorane. Organic Letters. 4: 201-3. PMID 11796050 DOI: 10.1021/Ol016941D |
0.387 |
|
| 2001 |
Waas WF, Dalby KN. Purification of a model substrate for transcription factor phosphorylation by ERK2 Protein Expression and Purification. 23: 191-197. PMID 11570862 DOI: 10.1006/Prep.2001.1491 |
0.813 |
|
| 2001 |
Waas WF, Lo HH, Dalby KN. The kinetic mechanism of the dual phosphorylation of the ATF2 transcription factor by p38 mitogen-activated protein (MAP) kinase α. Implications for signal/response profiles of MAP kinase pathways Journal of Biological Chemistry. 276: 5676-5684. PMID 11069918 DOI: 10.1074/Jbc.M008787200 |
0.825 |
|
| 1998 |
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. The Journal of Biological Chemistry. 273: 1496-505. PMID 9430688 DOI: 10.1074/Jbc.273.3.1496 |
0.519 |
|
| 1997 |
Dalby KN, Jencks WP. General acid catalysis of the reversible addition of thiolate anions to cyanamide Journal of the Chemical Society. Perkin Transactions 2. 1555-1563. DOI: 10.1039/A700205J |
0.555 |
|
| 1997 |
Dalby KN, Jencks WP. Lifetimes of imidinium ions in aqueous solution Journal of the American Chemical Society. 119: 7271-7280. DOI: 10.1021/ja970628i |
0.524 |
|
| 1995 |
MacKintosh RW, Dalby KN, Campbell DG, Cohen PT, Cohen P, MacKintosh C. The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. Febs Letters. 371: 236-40. PMID 7556599 DOI: 10.1016/0014-5793(95)00888-G |
0.41 |
|
| 1995 |
Leighton IA, Dalby KN, Caudwell FB, Cohen PT, Cohen P. Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation. Febs Letters. 375: 289-93. PMID 7498520 DOI: 10.1016/0014-5793(95)01170-J |
0.481 |
|
| 1994 |
Dalby KN, Kirby AJ, Hollfelder F. Simple but efficient models for nuclease catalysis Pure and Applied Chemistry. 66: 687-694. DOI: 10.1351/Pac199466040687 |
0.735 |
|
| 1993 |
Dalby KN, Kirby AJ, Hollfelder F. Models for nuclease catalysis: Mechanisms for general acid catalysis of the rapid intramolecular displacement of methoxide from a phosphate diester Journal of the Chemical Society, Perkin Transactions 2. 1269-1281. |
0.64 |
|
| 1992 |
Dalby KN, Hollfelder F, Kirby AJ. Electrostatic catalysis of the hydrolysis of a phosphate diester in water Journal of the Chemical Society, Chemical Communications. 1770-1771. DOI: 10.1039/C39920001770 |
0.735 |
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| Show low-probability matches. |