Kenneth A. Jacobson - Related publications

Molecular Recognition NIDDK, NIH, Bethesda, MD, United States 
GPCRs, adenosine, P2 receptors
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29 most relevant papers in past 60 days:
Year Citation  Score
2022 Szczepańska K, Podlewska S, Dichiara M, Gentile D, Patamia V, Rosier N, Mönnich D, Ruiz Cantero MC, Karcz T, Łażewska D, Siwek A, Pockes S, Cobos EJ, Marrazzo A, Stark H, et al. Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties. Acs Chemical Neuroscience. 13: 1-15. PMID 34908391 DOI: 10.1021/acschemneuro.1c00435   
2022 Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z. Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nature Communications. 13: 300. PMID 35027551 DOI: 10.1038/s41467-022-27975-9   
2022 Dichiara M, Artacho-Cordón A, Turnaturi R, Santos-Caballero M, González-Cano R, Pasquinucci L, Barbaraci C, Rodríguez-Gómez I, Gómez-Guzmán M, Marrazzo A, Cobos EJ, Amata E. Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. European Journal of Medicinal Chemistry. 230: 114091. PMID 35016113 DOI: 10.1016/j.ejmech.2021.114091   
2022 Duarte DA, Parreiras-E-Silva LT, Oliveira EB, Bouvier M, Costa-Neto CM. Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time. Hypertension (Dallas, Tex. : 1979). 79: 115-125. PMID 34739768 DOI: 10.1161/HYPERTENSIONAHA.121.17977   
2022 Hou Z, Jin Y, Li Y, Fan H, Xiao C, Li Q, Zhang Y. Immobilization of peroxisome proliferator-activated receptor gamma and the application in screening modulators of the receptor from herbal medicine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1190: 123098. PMID 35026651 DOI: 10.1016/j.jchromb.2022.123098   
2022 Hou Y, Wang C, Lu J, Jia M, Lv Y, Jia X, Zhu Q, Si M, He H, He L. Design and synthesis of first environment-sensitive coumarin fluorescent agonists for MrgX2. International Journal of Biological Macromolecules. PMID 35051504 DOI: 10.1016/j.ijbiomac.2022.01.037   
2022 Taban Q, Mumtaz PT, Masoodi KZ, Haq E, Ahmad SM. Scavenger receptors in host defense: from functional aspects to mode of action. Cell Communication and Signaling : Ccs. 20: 2. PMID 34980167 DOI: 10.1186/s12964-021-00812-0   
2022 Finlay DB, Nguyen T, Gamage TF, Chen S, Barrus DG, Patel PR, Thomas BF, Wiley JL, Zhang Y, Glass M. Exploring determinants of agonist efficacy at the CB1 cannabinoid receptor: Analogues of the synthetic cannabinoid receptor agonist EG-018. Pharmacology Research & Perspectives. 10: e00901. PMID 35041297 DOI: 10.1002/prp2.901   
2022 Rico MI, Lebedenko CG, Mitchell SM, Banerjee IA. Molecular dynamics simulations, docking and MMGBSA studies of newly designed peptide-conjugated glucosyloxy stilbene derivatives with tumor cell receptors. Molecular Diversity. PMID 35037187 DOI: 10.1007/s11030-021-10354-9   
2022 Manhas J, Edelstein HI, Leonard JN, Morsut L. The evolution of synthetic receptor systems. Nature Chemical Biology. PMID 35058646 DOI: 10.1038/s41589-021-00926-z   
2022 Morstein J, Romano G, Hetzler B, Plante A, Haake C, Levitz J, Trauner D. Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor. Angewandte Chemie (International Ed. in English). PMID 34989082 DOI: 10.1002/anie.202117094   
2022 Joshi M, Nikte SV, Sengupta D. Molecular determinants of GPCR pharmacogenetics: Deconstructing the population variants in β-adrenergic receptor. Advances in Protein Chemistry and Structural Biology. 128: 361-396. PMID 35034724 DOI: 10.1016/bs.apcsb.2021.08.002   
2022 Zhang W, Zhao S, Lu L, Fan Z, Ye S. Activation of neurotrophin signalling with light‑inducible receptor tyrosine kinases. Molecular Medicine Reports. 25. PMID 35014690 DOI: 10.3892/mmr.2022.12586   
2022 Nishioka M, Kamada T, Nakata A, Shiokawa N, Kinoshita A, Hata T. Intra-dorsal striatal acetylcholine M1 but not dopaminergic D1 or glutamatergic NMDA receptor antagonists inhibit consolidation of duration memory in interval timing. Behavioural Brain Research. 419: 113669. PMID 34800548 DOI: 10.1016/j.bbr.2021.113669   
2022 Zimmermann A, Vu O, Brüser A, Sliwoski G, Marnett LJ, Meiler J, Schöneberg T. Mapping the binding sites of UDP and prostaglandin E2 glyceryl ester in the nucleotide receptor P2Y6. Chemmedchem. PMID 35034430 DOI: 10.1002/cmdc.202100683   
2022 Akins N, Mishra N, Harris H, Dudhipala N, Kim SJ, Keasling A, Majumdar S, Zjawiony J, Paris J, Ashpole N, Le H. 6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects. Chemmedchem. PMID 35043597 DOI: 10.1002/cmdc.202100684   
2022 Portales AE, Mustafá ER, McCarthy CI, Cornejo MP, Couto PM, Gironacci MM, Caramelo JJ, Perelló M, Raingo J. ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors. Life Sciences. 293: 120284. PMID 35038454 DOI: 10.1016/j.lfs.2021.120284   
2022 White C, Rottschäfer V, Bridge LJ. Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis. Journal of Theoretical Biology. 110996. PMID 35085533 DOI: 10.1016/j.jtbi.2021.110996   
2022 Iyer MR, Cinar R, Wood CM, Zawatsky CN, Coffey NJ, Kim KA, Liu Z, Katz A, Abdalla J, Hassan SA, Lee YS. Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CBR) Receptor with Reduced Lipophilicity. Journal of Medicinal Chemistry. PMID 35084860 DOI: 10.1021/acs.jmedchem.1c01836   
2022 Conroy JN, Coulson EJ. High-affinity TrkA and p75 neurotrophin receptor complexes: a twisted affair. The Journal of Biological Chemistry. 101568. PMID 35051416 DOI: 10.1016/j.jbc.2022.101568   
2022 Babaahmadi-Rezaei H, Little PJ, Mohamed R, Zadeh GM, Kheirollah A, Mehr RN, Kamato D, Dayati P. Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor. Molecular and Cellular Biochemistry. PMID 34982346 DOI: 10.1007/s11010-021-04342-8   
2022 Dijkstra FM, Zuiker RGJA, Siebenga PS, Leigh-Pemberton RA, Sun L, Manthis JD, de Kam ML, Lin R, von Moltke LL, Rezendes D, van Gerven JMA. Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers. British Journal of Clinical Pharmacology. PMID 35014069 DOI: 10.1111/bcp.15229   
2022 Takeshita Y, Kita Y, Tanaka T, Goto H, Nakano Y, Teramura C, Enyama Y, Takamura T, . Insulin-GLP-1 receptor agonist relay and GLP-1 receptor agonist first regimens in individuals with type 2 diabetes: a randomized, open-label trial study. Journal of Diabetes Investigation. PMID 35034428 DOI: 10.1111/jdi.13749   
2022 Acher FC, Cabayé A, Eshak F, Goupil-Lamy A, Pin JP. Metabotropic glutamate receptor orthosteric ligands and their binding sites. Neuropharmacology. 204: 108886. PMID 34813860 DOI: 10.1016/j.neuropharm.2021.108886   
2022 Ginsburg BC, Hensler JG. Age-related changes in CB1 receptor expression and function and the behavioral effects of cannabinoid receptor ligands. Pharmacology, Biochemistry, and Behavior. 173339. PMID 35077729 DOI: 10.1016/j.pbb.2022.173339   
2022 Wang C, Sun S, Jiao J, Yu X, Huang S. Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats. Bmc Anesthesiology. 22: 19. PMID 35021986 DOI: 10.1186/s12871-022-01568-x   
2022 Park SJ, Yeon SK, Kim Y, Kim HJ, Kim S, Kim J, Choi JW, Kim B, Lee EH, Kim R, Seo SH, Lee J, Kim JW, Lee HY, Hwang H, et al. Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis. Journal of Medicinal Chemistry. PMID 35077170 DOI: 10.1021/acs.jmedchem.1c01979   
2022 Fernández DI, Provenzale I, Cheung HYF, van Groningen J, Tullemans BME, Veninga A, Dunster JL, Honarnejad S, van den Hurk H, Kuijpers MJE, Heemskerk JWM. Ultra-high-throughput Ca assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation. Iscience. 25: 103718. PMID 35072010 DOI: 10.1016/j.isci.2021.103718   
2022 Hino T, Saitoh T, Nagumo Y, Yamamoto N, Kutsumura N, Irukayama-Tomobe Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H. Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton. Bioorganic & Medicinal Chemistry Letters. 128530. PMID 35007725 DOI: 10.1016/j.bmcl.2022.128530