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Zhenghe Wang, Ph.D. - Publications

Affiliations: 
2001 University of Virginia, Charlottesville, VA 
Area:
Genetics, Microbiology Biology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhao Y, Feng X, Chen Y, Selfridge JE, Gorityala S, Du Z, Wang JM, Hao Y, Cioffi G, Conlon RA, Barnholtz-Sloan JS, Saltzman J, Krishnamurthi SS, Vinayak S, Veigl M, ... ... Wang Z, et al. 5-fluorouracil enhances the anti-tumor activity of the glutaminase inhibitor CB-839 against PIK3CA-mutant colorectal cancers. Cancer Research. PMID 32907836 DOI: 10.1158/0008-5472.Can-20-0600  0.385
2019 Zhao Y, Zhao X, Chen V, Feng Y, Wang L, Croniger C, Conlon RA, Markowitz S, Fearon E, Puchowicz M, Brunengraber H, Hao Y, Wang Z. Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo. Scientific Reports. 9: 19180. PMID 31844152 DOI: 10.1038/S41598-019-55718-2  0.364
2019 Bowler EH, Smith-Vidal A, Lester A, Bell J, Wang Z, Bell CG, Wang Y, Divecha N, Skipp PJ, Ewing RM. Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin. Epigenetics. 1-15. PMID 31448663 DOI: 10.1080/15592294.2019.1656154  0.38
2019 Zhao Y, Eads J, Bajor D, wang z. Abstract LB-294: Targeting glutamine addiction of PIK3CA mutant colorectal cancers: From preclinical models to clinical trials Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-294  0.349
2018 Eads JR, Krishnamurthi SS, Saltzman JN, Bajor DL, Vinayak S, Barnholtz-Sloan J, Meropol NJ, Markowitz SD, Wang Z. Phase I clinical trial of the glutaminase inhibitor CB-839 plus capecitabine in patients with advanced solid tumors. Journal of Clinical Oncology. 36: 2562-2562. DOI: 10.1200/Jco.2018.36.15_Suppl.2562  0.351
2018 Zhao Y, Wang Z. Abstract 2379: PTPRT pseudo-phosphatase domain is a denitrase that contributes to its tumor suppressor function Cancer Research. 78: 2379-2379. DOI: 10.1158/1538-7445.Am2018-2379  0.354
2016 Feng X, Hao Y, Wang Z. Targeting glutamine metabolism in mutant colorectal cancers. Genes & Diseases. 3: 241-243. PMID 30258894 DOI: 10.1016/J.Gendis.2016.09.001  0.354
2016 Zhao Y, Scott A, Zhang P, Hao Y, Feng X, Somasundaram S, Khalil AM, Willis J, Wang Z. Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. Oncotarget. PMID 27447856 DOI: 10.18632/Oncotarget.10654  0.36
2016 Peyser ND, Wang L, Zeng Y, Acquafondata M, Freilino ML, Li H, Sen M, Gooding WE, Satake M, Wang Z, Johnson DE, Grandis JR. STAT3 as a chemoprevention target in carcinogen-induced head and neck squamous cell carcinoma. Cancer Prevention Research (Philadelphia, Pa.). PMID 27267892 DOI: 10.1158/1940-6207.Capr-16-0089  0.311
2016 Wang Z. Abstract B03: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancers Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B03  0.386
2016 Fink SP, Myeroff L, Kariv R, Platzer P, Xin B, Mikkola D, Lawrence E, Morris N, Nosrati A, Willson J, Willis J, Veigl M, Barnholtz-Sloan J, Wang Z, Markowitz S. Abstract 3126: CEMIP, a secreted protein highly induced in colon cancer and associated with poor patient survival Cancer Research. 76: 3126-3126. DOI: 10.1158/1538-7445.Am2016-3126  0.342
2015 Guan D, Factor D, Liu Y, Wang Z, Kao HY. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 34: 5206. PMID 26424573 DOI: 10.1038/Onc.2015.314  0.3
2015 Bowler EH, Wang Z, Ewing RM. How do oncoprotein mutations rewire protein-protein interaction networks? Expert Review of Proteomics. 1-7. PMID 26325016 DOI: 10.1586/14789450.2015.1084875  0.336
2015 Zhao S, Sedwick D, Wang Z. Genetic alterations of protein tyrosine phosphatases in human cancers. Oncogene. 34: 3885-3894. PMID 25263441 DOI: 10.1038/Onc.2014.326  0.39
2015 Hao Y, Samuels Y, Li Q, Krokowski D, Brunengraber H, Hatzoglou M, Zhang G, Vogelstein B, Wang Z. Abstract 1125: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancers Cancer Research. 75: 1125-1125. DOI: 10.1158/1538-7445.Am2015-1125  0.396
2014 Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, et al. Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: 1114-9. PMID 24395800 DOI: 10.1073/Pnas.1319551111  0.379
2014 Scott A, Song J, Ewing R, Wang Z. Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications. Acta Biochimica Et Biophysica Sinica. 46: 199-203. PMID 24389641 DOI: 10.1093/Abbs/Gmt146  0.381
2014 Liu B, Cong R, Peng B, Zhu B, Dou G, Ai H, Zhang X, Wang Z, Xu X. CtIP is required for DNA damage-dependent induction of P21. Cell Cycle (Georgetown, Tex.). 13: 90-5. PMID 24196441 DOI: 10.4161/Cc.26810  0.366
2013 Guan D, Factor D, Liu Y, Wang Z, Kao HY. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 32: 3819-28. PMID 22945642 DOI: 10.1038/Onc.2012.406  0.36
2013 Zhang P, Guo A, Possemato A, Wang C, Beard L, Carlin C, Markowitz SD, Polakiewicz RD, Wang Z. Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14. Oncogene. 32: 2087-95. PMID 22710723 DOI: 10.1038/Onc.2012.220  0.382
2013 Hao Y, Wang C, Zheng W, Sedwick D, Markowitz S, Ewing R, Liu L, Wang Z. Abstract 5155: Gain of direct interaction with IRS1 by the helical domain mutations of p110 alpha is crucial for their oncogenic functions. Cancer Research. 73: 5155-5155. DOI: 10.1158/1538-7445.Am2013-5155  0.378
2012 Wang J, Han X, Feng X, Wang Z, Zhang Y. Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability. The Journal of Biological Chemistry. 287: 25501-9. PMID 22692200 DOI: 10.1074/jbc.M112.350397  0.31
2012 Lee H, Zhang P, Herrmann A, Yang C, Xin H, Wang Z, Hoon DS, Forman SJ, Jove R, Riggs AD, Yu H. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 7765-9. PMID 22547799 DOI: 10.1073/Pnas.1205132109  0.353
2012 Zhang P, Wang Z. Abstract 229: Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase non-receptor type 14 Cancer Research. 72: 229-229. DOI: 10.1158/1538-7445.Am2012-229  0.399
2011 Zhang P, Zhao Y, Zhu X, Sedwick D, Zhang X, Wang Z. Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis. Molecular Cancer Research : McR. 9: 1418-28. PMID 21840932 DOI: 10.1158/1541-7786.Mcr-11-0147  0.364
2011 Scott A, Wang Z. Tumour suppressor function of protein tyrosine phosphatase receptor-T. Bioscience Reports. 31: 303-7. PMID 21517784 DOI: 10.1042/Bsr20100134  0.362
2010 Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao HY, Xu Y, Willis J, Markowitz SD, Sedwick D, Ewing RM, Wang Z. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Science Signaling. 3: ra80. PMID 21045206 DOI: 10.1126/Scisignal.2001462  0.415
2010 Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC. CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Human Molecular Genetics. 19: 3491-501. PMID 20591827 DOI: 10.1093/Hmg/Ddq265  0.365
2010 Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, ... Wang Z, et al. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proceedings of the National Academy of Sciences of the United States of America. 107: 2592-7. PMID 20133777 DOI: 10.1073/Pnas.0914884107  0.392
2009 de Oliveira PE, Zhang L, Wang Z, Lazo JS. Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. Cell Cycle (Georgetown, Tex.). 8: 3157-64. PMID 19738433 DOI: 10.4161/Cc.8.19.9704  0.355
2009 Schnetz MP, Bartels CF, Shastri K, Balasubramanian D, Zentner GE, Balaji R, Zhang X, Song L, Wang Z, Laframboise T, Crawford GE, Scacheri PC. Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Research. 19: 590-601. PMID 19251738 DOI: 10.1101/Gr.086983.108  0.337
2008 Zhang X, Guo C, Chen Y, Shulha HP, Schnetz MP, LaFramboise T, Bartels CF, Markowitz S, Weng Z, Scacheri PC, Wang Z. Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies. Nature Methods. 5: 163-5. PMID 18176569 DOI: 10.1038/Nmeth1170  0.331
2004 Spinette S, Lengauer C, Mahoney JA, Jallepalli PV, Wang Z, Casciola-Rosen L, Rosen A. Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Cell Cycle (Georgetown, Tex.). 3: 1638-44. PMID 15611659 DOI: 10.4161/Cc.3.12.1345  0.342
2004 Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science (New York, N.Y.). 304: 1164-6. PMID 15155950 DOI: 10.1126/Science.1096096  0.389
2004 Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Research. 64: 2998-3001. PMID 15126332 DOI: 10.1158/0008-5472.Can-04-0587  0.371
2004 Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science (New York, N.Y.). 304: 554. PMID 15016963 DOI: 10.1126/Science.1096502  0.323
2003 Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 1931-6. PMID 12574499 DOI: 10.1073/Pnas.2627984100  0.322
2002 Wang Z, Castaño IB, Adams C, Vu C, Fitzhugh D, Christman MF. Structure/function analysis of the Saccharomyces cerevisiae Trf4/Pol sigma DNA polymerase. Genetics. 160: 381-91. PMID 11861546  0.679
2001 Wang Z, Christman MF. Replication-related activities establish cohesion between sister chromatids. Cell Biochemistry and Biophysics. 35: 289-301. PMID 11894848 DOI: 10.1385/CBB:35:3:289  0.613
2001 Burgers PM, Koonin EV, Bruford E, Blanco L, Burtis KC, Christman MF, Copeland WC, Friedberg EC, Hanaoka F, Hinkle DC, Lawrence CW, Nakanishi M, Ohmori H, Prakash L, Prakash S, ... ... Wang Z, et al. Eukaryotic DNA polymerases: proposal for a revised nomenclature. The Journal of Biological Chemistry. 276: 43487-90. PMID 11579108 DOI: 10.1074/Jbc.R100056200  0.532
2000 Wang Z, Castaño IB, De Las Peñas A, Adams C, Christman MF. Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science (New York, N.Y.). 289: 774-9. PMID 10926539 DOI: 10.1126/Science.289.5480.774  0.675
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