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Henry R. Bourne - Publications

Affiliations: 
Pharmacology University of California, San Francisco, San Francisco, CA 
Website:
http://www.cmpharm.ucsf.edu/bourne/

211 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Bourne HR, Lively MO. Iceberg alert for NIH. Science (New York, N.Y.). 337: 390. PMID 22767896 DOI: 10.1126/science.1226460  1
2009 Bourne HR. Ambition, surprise and delight: necessary lessons. Nature Cell Biology. 11: 1046. PMID 19724256 DOI: 10.1038/ncb0909-1046  1
2007 Wong K, Van Keymeulen A, Bourne HR. PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. The Journal of Cell Biology. 179: 1141-8. PMID 18086913 DOI: 10.1083/jcb.200706167  1
2007 Herzmark P, Campbell K, Wang F, Wong K, El-Samad H, Groisman A, Bourne HR. Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proceedings of the National Academy of Sciences of the United States of America. 104: 13349-54. PMID 17684096 DOI: 10.1073/pnas.0705889104  1
2007 Xu J, Van Keymeulen A, Wakida NM, Carlton P, Berns MW, Bourne HR. Polarity reveals intrinsic cell chirality. Proceedings of the National Academy of Sciences of the United States of America. 104: 9296-300. PMID 17517645 DOI: 10.1073/pnas.0703153104  1
2006 Bourne HR. G-proteins and GPCrs: from the beginning. Ernst Schering Foundation Symposium Proceedings. 1-21. PMID 17703575  1
2006 Onsum MD, Wong K, Herzmark P, Bourne HR, Arkin AP. Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification. Physical Biology. 3: 190-9. PMID 17021383 DOI: 10.1088/1478-3975/3/3/004  1
2006 Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442: 457-60. PMID 16871217 DOI: 10.1038/nature04925  1
2006 Wong K, Pertz O, Hahn K, Bourne H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 103: 3639-44. PMID 16537448 DOI: 10.1073/pnas.0600092103  1
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/journal.pbio.0040038  1
2005 Bourne HR. Rac and cell migration: CDM proteins integrate signals. Nature Cell Biology. 7: 777-8. PMID 16056271 DOI: 10.1038/ncb0805-777  1
2005 Xu J, Wang F, Van Keymeulen A, Rentel M, Bourne HR. Neutrophil microtubules suppress polarity and enhance directional migration. Proceedings of the National Academy of Sciences of the United States of America. 102: 6884-9. PMID 15860582 DOI: 10.1073/pnas.0502106102  1
2005 Buck E, Bourne H, Wells JA. Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. The Journal of Biological Chemistry. 280: 4009-12. PMID 15550394 DOI: 10.1074/jbc.C400500200  1
2003 Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 114: 201-14. PMID 12887922 DOI: 10.1016/S0092-8674(03)00555-5  1
2003 Yu W, O'Brien LE, Wang F, Bourne H, Mostov KE, Zegers MM. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Molecular Biology of the Cell. 14: 748-63. PMID 12589067 DOI: 10.1091/mbc.E02-06-0350  1
2003 Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. The Journal of Cell Biology. 160: 375-85. PMID 12551955 DOI: 10.1083/jcb.200208179  1
2002 Sambrano GR, Chandy G, Choi S, Decamp D, Hsueh R, Lin KM, Mock D, O'Rourke N, Roach T, Shu H, Sinkovits B, Verghese M, Bourne H. Unravelling the signal-transduction network in B lymphocytes. Nature. 420: 708-10. PMID 12478302 DOI: 10.1038/nature01305  1
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/nature01304  1
2002 Whistler JL, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic (Copenhagen, Denmark). 3: 866-77. PMID 12453150 DOI: 10.1034/j.1600-0854.2002.31203.x  1
2002 Bourne HR, Weiner O. A chemical compass. Nature. 419: 21. PMID 12214215 DOI: 10.1038/419021a  1
2002 Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology. 4: 509-13. PMID 12080346 DOI: 10.1038/ncb811  1
2002 Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology. 4: 513-8. PMID 12080345 DOI: 10.1038/ncb810  1
2002 Bourne HR, O'Shea EK. Cell regulation Current Opinion in Cell Biology. 14: 137-139. DOI: 10.1016/S0955-0674(02)00320-4  1
2001 Meng EC, Bourne HR. Receptor activation: what does the rhodopsin structure tell us? Trends in Pharmacological Sciences. 22: 587-93. PMID 11698103 DOI: 10.1016/S0165-6147(00)01825-3  1
2001 Rondard P, Iiri T, Srinivasan S, Meng E, Fujita T, Bourne HR. Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation? Proceedings of the National Academy of Sciences of the United States of America. 98: 6150-5. PMID 11344266 DOI: 10.1073/pnas.101136198  1
2001 Gerber BO, Meng EC, Dotsch V, Baranski TJ, Bourne HR. An activation switch in the ligand binding pocket of the C5a receptor. The Journal of Biological Chemistry. 276: 3394-400. PMID 11062244 DOI: 10.1074/jbc.M007748200  1
2000 Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends in Cell Biology. 10: 466-73. PMID 11050418 DOI: 10.1016/S0962-8924(00)01841-9  1
2000 Bourne HR, Meng EC. Structure. Rhodopsin sees the light. Science (New York, N.Y.). 289: 733-4. PMID 10950717 DOI: 10.1126/science.289.5480.733  1
2000 Haggarty SJ, Ramalho-Santos M. Will cell alliance breed bureaucracy and leave contributors out? Nature. 403: 591. PMID 10688171 DOI: 10.1038/35001228  1
2000 Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (New York, N.Y.). 287: 1037-40. PMID 10669415 DOI: 10.1126/science.287.5455.1037  1
2000 Fishburn CS, Pollitt SK, Bourne HR. Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z). Proceedings of the National Academy of Sciences of the United States of America. 97: 1085-90. PMID 10655488 DOI: 10.1073/pnas.97.3.1085  1
1999 Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology. 1: 75-81. PMID 10559877 DOI: 10.1038/10042  1
1999 Fishburn CS, Herzmark P, Morales J, Bourne HR. Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membrane. The Journal of Biological Chemistry. 274: 18793-800. PMID 10373496 DOI: 10.1074/jbc.274.26.18793  1
1999 Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. The Journal of Biological Chemistry. 274: 17033-41. PMID 10358054 DOI: 10.1074/jbc.274.24.17033  1
1999 Baranski TJ, Herzmark P, Lichtarge O, Gerber BO, Trueheart J, Meng EC, Iiri T, Sheikh SP, Bourne HR. C5a receptor activation. Genetic identification of critical residues in four transmembrane helices. The Journal of Biological Chemistry. 274: 15757-65. PMID 10336477 DOI: 10.1074/jbc.274.22.15757  0.32
1999 Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Molecular Biology of the Cell. 10: 1163-78. PMID 10198064  1
1999 Farfel Z, Bourne HR, Iiri T. The expanding spectrum of G protein diseases. The New England Journal of Medicine. 340: 1012-20. PMID 10099144 DOI: 10.1056/NEJM199904013401306  1
1999 Neptune ER, Iiri T, Bourne HR. Galphai is not required for chemotaxis mediated by Gi-coupled receptors. The Journal of Biological Chemistry. 274: 2824-8. PMID 9915816 DOI: 10.1074/jbc.274.5.2824  1
1999 Iiri T, Bell SM, Baranski TJ, Fujita T, Bourne HR. A Gsalpha mutant designed to inhibit receptor signaling through Gs. Proceedings of the National Academy of Sciences of the United States of America. 96: 499-504. PMID 9892662 DOI: 10.1073/pnas.96.2.499  1
1998 Apanovitch DM, Iiri T, Karasawa T, Bourne HR, Dohlman HG. Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling. The Journal of Biological Chemistry. 273: 28597-602. PMID 9786851 DOI: 10.1074/jbc.273.44.28597  1
1998 Iiri T, Farfel Z, Bourne HR. G-protein diseases furnish a model for the turn-on switch. Nature. 394: 35-8. PMID 9665125 DOI: 10.1038/27831  1
1998 Morales J, Fishburn CS, Wilson PT, Bourne HR. Plasma membrane localization of G alpha z requires two signals. Molecular Biology of the Cell. 9: 1-14. PMID 9436987  1
1998 Iiri T, Bourne HR. G proteins propel surprise. Nature Genetics. 18: 8-10. PMID 9425887 DOI: 10.1038/ng0198-8  1
1997 Bourne HR. Pieces of the true grail: a G protein finds its target. Science (New York, N.Y.). 278: 1898-9. PMID 9417637 DOI: 10.1126/science.278.5345.1898  1
1997 Neptune ER, Bourne HR. Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proceedings of the National Academy of Sciences of the United States of America. 94: 14489-94. PMID 9405640 DOI: 10.1073/pnas.94.26.14489  1
1997 Bourne HR. G proteins. The arginine finger strikes again. Nature. 389: 673-4. PMID 9338774 DOI: 10.1038/39470  1
1997 Iiri T, Farfel Z, Bourne HR. Conditional activation defect of a human Gsalpha mutant. Proceedings of the National Academy of Sciences of the United States of America. 94: 5656-61. PMID 9159128 DOI: 10.1073/pnas.94.11.5656  1
1997 Yan Y, Chi PP, Bourne HR. RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. The Journal of Biological Chemistry. 272: 11924-7. PMID 9115254 DOI: 10.1074/jbc.272.18.11924  1
1997 Bourne HR. How receptors talk to trimeric G proteins. Current Opinion in Cell Biology. 9: 134-42. PMID 9069253 DOI: 10.1016/S0955-0674(97)80054-3  1
1997 Onrust R, Herzmark P, Chi P, Garcia PD, Lichtarge O, Kingsley C, Bourne HR. Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin. Science (New York, N.Y.). 275: 381-4. PMID 8994033 DOI: 10.1126/science.275.5298.381  1
1996 Iiri T, Backlund PS, Jones TL, Wedegaertner PB, Bourne HR. Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 93: 14592-7. PMID 8962097  1
1996 Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR. Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Molecular Pharmacology. 50: 885-90. PMID 8863834  1
1996 Wedegaertner PB, Bourne HR, von Zastrow M. Activation-induced subcellular redistribution of Gs alpha. Molecular Biology of the Cell. 7: 1225-33. PMID 8856666  1
1996 Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature. 383: 347-50. PMID 8848049 DOI: 10.1038/383347a0  1
1996 Lichtarge O, Bourne HR, Cohen FE. Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex. Proceedings of the National Academy of Sciences of the United States of America. 93: 7507-11. PMID 8755504  1
1996 Voyno-Yasenetskaya TA, Faure MP, Ahn NG, Bourne HR. Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. The Journal of Biological Chemistry. 271: 21081-7. PMID 8702875 DOI: 10.1074/jbc.271.35.21081  1
1996 Farfel Z, Iiri T, Shapira H, Roitman A, Mouallem M, Bourne HR. Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation. The Journal of Biological Chemistry. 271: 19653-5. PMID 8702665 DOI: 10.1074/jbc.271.33.19653  1
1996 Lichtarge O, Bourne HR, Cohen FE. An evolutionary trace method defines binding surfaces common to protein families. Journal of Molecular Biology. 257: 342-58. PMID 8609628 DOI: 10.1006/jmbi.1996.0167  1
1995 Vermeij GJ. Through the glass lightly. Science (New York, N.Y.). 267: 1617. PMID 17808170 DOI: 10.1126/science.267.5204.1617-d  1
1995 Pace AM, Faure M, Bourne HR. Gi2-mediated activation of the MAP kinase cascade. Molecular Biology of the Cell. 6: 1685-95. PMID 8590798  1
1995 Bourne HR. GTPases: a family of molecular switches and clocks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 349: 283-9. PMID 8577839 DOI: 10.1098/rstb.1995.0114  1
1995 Iiri T, Homma Y, Ohoka Y, Robishaw JD, Katada T, Bourne HR. Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells. Possible role of G gamma 2. The Journal of Biological Chemistry. 270: 5901-8. PMID 7890721  1
1995 Wedegaertner PB, Wilson PT, Bourne HR. Lipid modifications of trimeric G proteins. The Journal of Biological Chemistry. 270: 503-6. PMID 7822269 DOI: 10.1074/jbc.270.2.503  1
1995 Wong YH, Chan JS, Yung LY, Bourne HR. Mutant alpha subunit of Gz transforms Swiss 3T3 cells. Oncogene. 10: 1927-33. PMID 7761094  1
1995 Bourne HR. Signal transduction. Team blue sees red. Nature. 376: 727-9. PMID 7651531 DOI: 10.1038/376727a0  1
1995 Faure M, Bourne HR. Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1. Molecular Biology of the Cell. 6: 1025-35. PMID 7579705  1
1995 Garcia PD, Onrust R, Bell SM, Sakmar TP, Bourne HR. Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. The Embo Journal. 14: 4460-9. PMID 7556089  1
1995 Wilson PT, Bourne HR. Fatty acylation of alpha z. Effects of palmitoylation and myristoylation on alpha z signaling. The Journal of Biological Chemistry. 270: 9667-75. PMID 7536745  1
1995 Benjamin DR, Markby DW, Bourne HR, Kuntz ID. Solution structure of the GTPase activating domain of alpha s. Journal of Molecular Biology. 254: 681-91. PMID 7500342 DOI: 10.1006/jmbi.1995.0647  1
1995 Bourne HR. Trimeric G proteins: surprise witness tells a tale. Science (New York, N.Y.). 270: 933-4. PMID 7481796 DOI: 10.1126/science.270.5238.933  1
1994 Bourne HR. G proteins. The importance of being GTP. Nature. 369: 611-2. PMID 8208286 DOI: 10.1038/369611a0  1
1994 Faure M, Voyno-Yasenetskaya TA, Bourne HR. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. The Journal of Biological Chemistry. 269: 7851-4. PMID 8132501  1
1994 Conklin BR, Bourne HR. Homeostatic signals. Marriage of the flytrap and the serpent. Nature. 367: 22. PMID 8107768 DOI: 10.1038/367022a0  1
1994 Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. G alpha 13 stimulates Na-H exchange. The Journal of Biological Chemistry. 269: 4721-4. PMID 8106440  1
1994 Iiri T, Herzmark P, Nakamoto JM, van Dop C, Bourne HR. Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature. 371: 164-8. PMID 8072545 DOI: 10.1038/371164a0  1
1994 Voyno-Yasenetskaya TA, Pace AM, Bourne HR. Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene. 9: 2559-65. PMID 8058319  1
1994 Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 370: 143-6. PMID 8022483 DOI: 10.1038/370143a0  1
1994 Wedegaertner PB, Bourne HR. Activation and depalmitoylation of Gs alpha. Cell. 77: 1063-70. PMID 7912657  1
1994 Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086  1
1994 Ma YH, Landis C, Tchao N, Wang J, Rodd G, Hanahan D, Bourne HR, Grodsky GM. Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion. Endocrinology. 134: 42-7. PMID 7506212 DOI: 10.1210/endo.134.1.7506212  1
1994 Bourne HR, Williams LT. Editorial overview Current Opinion in Cell Biology. 6: 161-162.  1
1994 Conklin BR, Bourne HR. Marriage of the flytrap and the serpent Nature. 367: 22.  1
1993 Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. The Journal of Biological Chemistry. 268: 13900-5. PMID 8390980  1
1993 Conklin BR, Bourne HR. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73: 631-41. PMID 8388779 DOI: 10.1016/0092-8674(93)90245-L  1
1993 Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 363: 274-6. PMID 8387644 DOI: 10.1038/363274a0  1
1993 Conklin BR, Bourne HR. Mouse coat colour reconsidered. Nature. 364: 110. PMID 8321283 DOI: 10.1038/364110b0  1
1993 Markby DW, Onrust R, Bourne HR. Separate GTP binding and GTPase activating domains of a G alpha subunit. Science (New York, N.Y.). 262: 1895-901. PMID 8266082  1
1993 Bourne HR. GTPases. A turn-on and a surprise. Nature. 366: 628-9. PMID 8259206 DOI: 10.1038/366628a0  1
1993 Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. The Journal of Biological Chemistry. 268: 25001-8. PMID 8227063  1
1993 Bourne HR, Nicoll R. Molecular machines integrate coincident synaptic signals. Cell. 72: 65-75. PMID 8094038 DOI: 10.1016/S0092-8674(05)80029-7  1
1992 Berlot CH, Bourne HR. Identification of effector-activating residues of Gs alpha. Cell. 68: 911-22. PMID 1547491 DOI: 10.1016/0092-8674(92)90034-A  1
1992 Goretzki PE, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark OH, McCormick F, Röher HD, Bourne HR. Mutational activation of RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications. World Journal of Surgery. 16: 576-81; discussion 5. PMID 1413827 DOI: 10.1007/BF02067325  1
1992 Wong YH, Conklin BR, Bourne HR. Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science (New York, N.Y.). 255: 339-42. PMID 1347957  1
1992 Bourne HR, Lustig KD, Wong YH, Conklin BR. Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harbor Symposia On Quantitative Biology. 57: 145-8. PMID 1339653  1
1992 Bourne HR, Stryer L. G proteins. The target sets the tempo. Nature. 358: 541-3. PMID 1323762 DOI: 10.1038/358541a0  1
1992 Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Molecular Endocrinology (Baltimore, Md.). 6: 551-6. PMID 1316547 DOI: 10.1210/mend.6.4.1316547  1
1992 Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature. 356: 159-61. PMID 1312225 DOI: 10.1038/356159a0  1
1992 Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. The Journal of Biological Chemistry. 267: 31-4. PMID 1309740  1
1992 Levis MJ, Bourne HR. Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. The Journal of Cell Biology. 119: 1297-307. PMID 1280272  1
1992 Bourne HR, Stryer L. Turning off GTP signals Nature. 358: 542.  1
1992 Bourne HR, Varmus HE. Oncogenes and cell proliferation Current Opinion in Genetics and Development. 2: 1-3.  1
1991 Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 349: 117-27. PMID 1898771 DOI: 10.1038/349117a0  1
1991 Wong YH, Federman A, Pace AM, Zachary I, Evans T, Pouysségur J, Bourne HR. Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature. 351: 63-5. PMID 1851251 DOI: 10.1038/351063a0  1
1991 Bourne HR. Colon cancer. Suppression with a difference. Nature. 353: 696-7. PMID 1658657 DOI: 10.1038/353696b0  1
1991 Pace AM, Wong YH, Bourne HR. A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 7031-5. PMID 1651490  1
1991 Bourne HR. Colon cancer. Consider the coiled coil.... Nature. 351: 188-90. PMID 1645848 DOI: 10.1038/351188a0  1
1990 Heideman W, Casperson GF, Bourne HR. Adenylyl cyclase in yeast: antibodies and mutations identify a regulatory domain. Journal of Cellular Biochemistry. 42: 229-42. PMID 2187889 DOI: 10.1002/jcb.240420406  1
1990 Bourne HR, Wrischnik L, Kenyon C. Ras proteins. Some signal developments. Nature. 348: 678-9. PMID 2175395 DOI: 10.1038/348678a0  1
1990 Zachary I, Masters SB, Bourne HR. Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha. Biochemical and Biophysical Research Communications. 168: 1184-93. PMID 2161217 DOI: 10.1016/0006-291X(90)91154-K  1
1990 Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 348: 125-32. PMID 2122258 DOI: 10.1038/348125a0  1
1990 Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. The Journal of Clinical Endocrinology and Metabolism. 71: 1416-20. PMID 2121775 DOI: 10.1210/jcem-71-6-1416  1
1990 Masters SB, Landis CA, Bourne HR. GTPase-inhibiting mutations in the alpha subunit of Gs. Advances in Second Messenger and Phosphoprotein Research. 24: 70-5. PMID 2119660  1
1990 Masters SB, Landis CA, Bourne HR. Mutational analysis of the structure and function of GTP-binding proteins. Advances in Enzyme Regulation. 30: 75-87. PMID 2119552 DOI: 10.1016/0065-2571(90)90010-Y  1
1990 Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR. Two G protein oncogenes in human endocrine tumors. Science (New York, N.Y.). 249: 655-9. PMID 2116665  1
1990 Jones DT, Masters SB, Bourne HR, Reed RR. Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. The Journal of Biological Chemistry. 265: 2671-6. PMID 2105931  1
1989 Bourne HR. G-protein subunits. Who carries what message? Nature. 337: 504. PMID 2644543 DOI: 10.1038/337504a0  1
1989 Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340: 692-6. PMID 2549426 DOI: 10.1038/340692a0  1
1989 Masters SB, Miller RT, Chi MH, Chang FH, Beiderman B, Lopez NG, Bourne HR. Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. The Journal of Biological Chemistry. 264: 15467-74. PMID 2549064  1
1989 Chang FH, Bourne HR. Cholera toxin induces cAMP-independent degradation of Gs. The Journal of Biological Chemistry. 264: 5352-7. PMID 2538415  1
1989 Bourne HR, Landis CA, Masters SB. Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins. Proteins. 6: 222-30. PMID 2516316 DOI: 10.1002/prot.340060304  1
1989 Bourne HR. Who carries what message? Nature. 337: 504-505.  1
1988 Bourne HR, Masters SB, Miller RT, Sullivan KA, Heideman W. Mutations probe structure and function of G-protein alpha chains. Cold Spring Harbor Symposia On Quantitative Biology. 53: 221-8. PMID 3151169  1
1988 Bourne HR. Preliminary structural model of the G-protein alpha-chain. Advances in Second Messenger and Phosphoprotein Research. 21: 33-8. PMID 3137960  1
1988 Miller RT, Masters SB, Sullivan KA, Beiderman B, Bourne HR. A mutation that prevents GTP-dependent activation of the alpha chain of Gs. Nature. 334: 712-5. PMID 3137475 DOI: 10.1038/334712a0  1
1988 Bourne HR. Signals past, present, and future. Cold Spring Harbor Symposia On Quantitative Biology. 53: 1019-31. PMID 3076092  1
1988 Yu VC, Hochhaus G, Chang FH, Richards ML, Bourne HR, Sadée W. Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid. Journal of Neurochemistry. 51: 1892-9. PMID 2903224 DOI: 10.1111/j.1471-4159.1988.tb01174.x  1
1988 Masters SB, Sullivan KA, Miller RT, Beiderman B, Lopez NG, Ramachandran J, Bourne HR. Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science (New York, N.Y.). 241: 448-51. PMID 2899356  1
1988 Bourne HR. Do GTPases direct membrane traffic in secretion? Cell. 53: 669-71. PMID 2836065  1
1988 Levine MA, Ahn TG, Klupt SF, Kaufman KD, Smallwood PM, Bourne HR, Sullivan KA, Van Dop C. Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. Proceedings of the National Academy of Sciences of the United States of America. 85: 617-21. PMID 2829196  1
1987 Chang FH, Bourne HR. Dexamethasone increases adenylyl cyclase activity and expression of the alpha-subunit of Gs in GH3 cells. Endocrinology. 121: 1711-5. PMID 3665842 DOI: 10.1210/endo-121-5-1711  1
1987 Ashley PL, Ellison J, Sullivan KA, Bourne HR, Cox DR. Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse. The Journal of Biological Chemistry. 262: 15299-301. PMID 3117797  1
1987 Bourne HR. Interleukin-2 and GTP binding in lymphocytes. Nature. 326: 833-4. PMID 3106824 DOI: 10.1038/326833b0  1
1987 Bourne HR, Masters SB, Sullivan KA. Mammalian G proteins: structure and function. Biochemical Society Transactions. 15: 35-8. PMID 3104111  1
1987 Heideman W, Casperson GF, Bourne HR. Adenylyl cyclase in yeast. Hydrodynamic properties and activation by trypsin. The Journal of Biological Chemistry. 262: 7087-91. PMID 3034880  1
1987 Casperson GF, Bourne HR. Biochemical and molecular genetic analysis of hormone-sensitive adenylyl cyclase. Annual Review of Pharmacology and Toxicology. 27: 371-84. PMID 3034141 DOI: 10.1146/annurev.pa.27.040187.002103  1
1987 Sullivan KA, Miller RT, Masters SB, Beiderman B, Heideman W, Bourne HR. Identification of receptor contact site involved in receptor-G protein coupling. Nature. 330: 758-60. PMID 2827032 DOI: 10.1038/330758a0  1
1987 Bourne HR. Discovery of a new oncogene in pituitary tumours? Nature. 330: 517-8. PMID 2825029 DOI: 10.1038/330517a0  1
1987 Bourne HR. 'Wrong' subunit regulates cardiac potassium channels. Nature. 325: 296-7. PMID 2433588 DOI: 10.1038/325296a0  1
1986 Masters SB, Stroud RM, Bourne HR. Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Engineering. 1: 47-54. PMID 3148932  1
1986 Stryer L, Bourne HR. G proteins: a family of signal transducers. Annual Review of Cell Biology. 2: 391-419. PMID 3103658 DOI: 10.1146/annurev.cb.02.110186.002135  1
1986 Bourne HR, Sullivan KA. Mammalian G proteins: models for ras proteins in transmembrane signalling? Cancer Surveys. 5: 257-74. PMID 3096565  1
1986 Sullivan KA, Liao YC, Alborzi A, Beiderman B, Chang FH, Masters SB, Levinson AD, Bourne HR. Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proceedings of the National Academy of Sciences of the United States of America. 83: 6687-91. PMID 3092218 DOI: 10.1073/pnas.83.18.6687  1
1986 Bourne HR. GTP-binding proteins. One molecular machine can transduce diverse signals. Nature. 321: 814-6. PMID 3088455 DOI: 10.1038/321814a0  1
1985 Bourne HR. Transducing proteins. Yeast RAS and Tweedledee's logic. Nature. 317: 16-7. PMID 3897870 DOI: 10.1038/317016b0  1
1985 Casperson GF, Walker N, Bourne HR. Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 82: 5060-3. PMID 2991907  1
1985 Goldman DW, Chang FH, Gifford LA, Goetzl EJ, Bourne HR. Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. The Journal of Experimental Medicine. 162: 145-56. PMID 2989409 DOI: 10.1084/jem.162.1.145  1
1985 Medynski DC, Sullivan K, Smith D, Van Dop C, Chang FH, Fung BK, Seeburg PH, Bourne HR. Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proceedings of the National Academy of Sciences of the United States of America. 82: 4311-5. PMID 2409555 DOI: 10.1073/pnas.82.13.4311  1
1984 Van Dop C, Tsubokawa M, Bourne HR, Ramachandran J. Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. The Journal of Biological Chemistry. 259: 696-8. PMID 6582062  1
1984 Bourne HR, Van Dop C, Casperson GF. Genetic and functional studies of guanine nucleotide-binding regulatory proteins. Advances in Experimental Medicine and Biology. 175: 85-98. PMID 6437161  1
1984 Bourne HR, Casperson GF, Van Dop C, Abood ME, Beiderman BB, Steinberg F, Walker N. Mutations of adenylate cyclase in yeast, mouse, and man. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 199-205. PMID 6328916  1
1984 Bourne HR, Brothers VM, Kaslow HR, Groppi V, Walker N, Steinberg F. Genetic analysis of cyclic nucleotide phosphodiesterases in S49 mouse lymphoma cells. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 16: 185-94. PMID 6326523  1
1984 Frey MJ, Chesrown SE, Reed BR, Greenspon LW, Shields RL, Bourne HR, Brown JK, Gold WM. Immunologic release of histamine from dog lung: comparison of in vivo and in vitro responses in the same animal. The Journal of Allergy and Clinical Immunology. 74: 728-37. PMID 6209322 DOI: 10.1016/0091-6749(84)90237-9  1
1984 Van Dop C, Medynski D, Sullivan K, Wu AM, Fung BK, Bourne HR. Partial cDNA sequence of the gamma subunit of transducin. Biochemical and Biophysical Research Communications. 124: 250-5. PMID 6149748 DOI: 10.1016/0006-291X(84)90944-6  1
1984 Van Dop C, Yamanaka G, Steinberg F, Sekura RD, Manclark CR, Stryer L, Bourne HR. ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. The Journal of Biological Chemistry. 259: 23-6. PMID 6142883  1
1984 Van Dop C, Bourne HR, Neer RM. Father to son transmission of decreased Ns activity in pseudohypoparathyroidism type Ia. The Journal of Clinical Endocrinology and Metabolism. 59: 825-8. PMID 6090498 DOI: 10.1210/jcem-59-5-825  1
1983 Casperson GF, Walker N, Brasier AR, Bourne HR. A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 258: 7911-4. PMID 6345532  1
1983 Van Dop C, Bourne HR. Pseudohypoparathyroidism. Annual Review of Medicine. 34: 259-66. PMID 6344759 DOI: 10.1146/annurev.me.34.020183.001355  1
1983 Fischer JA, Bourne HR, Dambacher MA, Tschopp F, De Meyer R, Devogelaer JP, Werder EA, Nagant De Deuxchaisnes C. Pseudohypoparathyroidism: inheritance and expression of deficient receptor-cyclase coupling protein activity. Clinical Endocrinology. 19: 747-54. PMID 6317236  1
1983 Groppi VE, Steinberg F, Kaslow HR, Walker N, Bourne HR. Identification by direct photoaffinity labeling of an altered phosphodiesterase in a mutant S49 lymphoma cell. The Journal of Biological Chemistry. 258: 9717-23. PMID 6309783  1
1983 Bourne HR, Steinberg F, Golbus MS, Farfel Z. A convenient method for measuring receptor-cyclase coupling activity in whole blood: application to Duchenne muscular dystrophy. American Journal of Medical Genetics. 15: 469-74. PMID 6309005 DOI: 10.1002/ajmg.1320150312  1
1982 Farfel Z, Bourne HR. Pseudohypoparathyroidism: mutation affecting adenylate cyclase. Mineral and Electrolyte Metabolism. 8: 227-36. PMID 6300633  1
1982 Bourne HR, Beiderman B, Steinberg F, Brothers VM. Three adenylate cyclase phenotypes in S49 lymphoma cells produced by mutations of one gene. Molecular Pharmacology. 22: 204-10. PMID 6289072  1
1982 Motulsky HJ, Hughes RJ, Brickman AS, Farfel Z, Bourne HR, Insel PA. Platelets of pseudohypoparathyroid patients: evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 79: 4193-7. PMID 6287473 DOI: 10.1073/pnas.79.13.4193  1
1982 Brothers VM, Walker N, Bourne HR. Increased cyclic nucleotide phosphodiesterase activity in a mutant S49 lymphoma cell. Characterization and comparison with wild type enzyme activity. The Journal of Biological Chemistry. 257: 9349-55. PMID 6286616  1
1982 Farfel Z, Abood ME, Brickman AS, Bourne HR. Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I. The Journal of Clinical Endocrinology and Metabolism. 55: 113-7. PMID 6281299 DOI: 10.1210/jcem-55-1-113  1
1982 Abood ME, Hurley JB, Pappone MC, Bourne HR, Stryer L. Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin. The Journal of Biological Chemistry. 257: 10540-3. PMID 6125514  1
1981 Kaslow HR, Groppi VE, Abood ME, Bourne HR. Cholera toxin can catalyze ADP-ribosylation of cytoskeletal proteins. The Journal of Cell Biology. 91: 410-3. PMID 7309789  1
1981 Farfel Z, Salomon MR, Bourne HR. Genetic investigation of adenylate cyclase: mutations in mouse and man. Annual Review of Pharmacology and Toxicology. 21: 251-64. PMID 7016006 DOI: 10.1146/annurev.pa.21.040181.001343  1
1981 Kaslow HR, Cox D, Groppi VE, Bourne HR. An Mr = 52,000 peptide can mediate effects on cholera toxin on adenylate cyclase in intact cells. Molecular Pharmacology. 19: 406-10. PMID 6790933  1
1981 Bourne HR, Farfel Z, Brickman AS, Kaslow HR, Brothers VM. Human mutation affecting hormone-sensitive adenylate cyclase. Progress in Clinical and Biological Research. 63: 433-7. PMID 6273928  1
1981 Bourne HR, Kaslow D, Kaslow HR, Salomon MR, Licko V. Hormone-sensitive adenylate cyclase. Mutant phenotype with normally regulated beta-adrenergic receptors uncoupled with catalytic adenylate cyclase. Molecular Pharmacology. 20: 435-41. PMID 6272096  1
1981 Bourne HR, Farfel Z, Brickman AS. Pseudohypoparathyroidism: an inherited disorder of adenylate cyclase. Advances in Cyclic Nucleotide Research. 14: 43-9. PMID 6269394  1
1981 Bourne HR, Kaslow HR, Brickman AS, Farfel Z. Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein. The Journal of Clinical Endocrinology and Metabolism. 53: 636-40. PMID 6267099 DOI: 10.1210/jcem-53-3-636  1
1981 Farfel Z, Brothers VM, Brickman AS, Conte F, Neer R, Bourne HR. Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity. Proceedings of the National Academy of Sciences of the United States of America. 78: 3098-102. PMID 6265935  1
1981 Salomon MR, Bourne HR. Novel S49 lymphoma variants with aberrant cyclic AMP metabolism. Molecular Pharmacology. 19: 109-16. PMID 6259507  1
1981 Farfel Z, Brickman AS, Kaslow HR, Brothers VM, Bourne HR. Defect of receptor-cyclase coupling protein in pseudohypoparathyroidism Obstetrical and Gynecological Survey. 36: 92-93.  1
1980 Kaslow HR, Johnson GL, Brothers VM, Bourne HR. A regulatory component of adenylate cyclase from human erythrocyte membranes. The Journal of Biological Chemistry. 255: 3736-41. PMID 7364766  1
1980 Farfel Z, Bourne HR. Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. 51: 1202-4. PMID 6252235 DOI: 10.1210/jcem-51-5-1202  1
1980 Johnson GL, Kaslow HR, Farfel Z, Bourne HR. Genetic analysis of hormone-sensitive adenylate cyclase. Advances in Cyclic Nucleotide Research. 13: 1-37. PMID 6251703  1
1980 Farfel Z, Brickman AS, Kaslow HR, Brothers VM, Bourne HR. Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. The New England Journal of Medicine. 303: 237-42. PMID 6247654 DOI: 10.1056/NEJM198007313030501  1
1979 Farfel Z, Kaslow HR, Bourne HR. A regulatory component of adenylate cyclase is located on the inner surface of human erythrocyte membranes. Biochemical and Biophysical Research Communications. 90: 1237-41. PMID 518596 DOI: 10.1016/0006-291X(79)91169-0  1
1979 Kaiser N, Bourne HR, Insel PA, Coffino P. Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent. Journal of Cellular Physiology. 101: 369-74. PMID 231036 DOI: 10.1002/jcp.1041010304  1
1979 Kaslow HR, Farfel Z, Johnson GL, Bourne HR. Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate. Molecular Pharmacology. 15: 472-83. PMID 226858  1
1979 Johnson GL, Bourne HR, Gleason MK, Coffino P, Insel PA, Melmon KL. Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. Molecular Pharmacology. 15: 16-27. PMID 34089  1
1978 Johnson GL, Kaslow HR, Bourne HR. Reconstitution of cholera toxin-activated adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 75: 3113-7. PMID 277913  1
1978 Barnett DB, Chesrown SE, Zbinden AF, Nisam M, Reed BR, Bourne HR, Melmon KL, Gold WM. Cyclic AMP and cyclic GMP in canine peripheral lung: regulation in vivo. The American Review of Respiratory Disease. 118: 723-33. PMID 212969  1
1978 Johnson GL, Kaslow HR, Bourne HR. Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. The Journal of Biological Chemistry. 253: 7120-3. PMID 212417  1
1978 Naya-Vigne J, Johnson GL, Bourne HR, Coffino P. Complementation analysis of hormone-sensitive adenylate cyclase. Nature. 272: 720-2. PMID 205796 DOI: 10.1038/272720a0  1
1978 Coffino P, Bourne HR, Insel PA, Melmon KL, Johnson G, Vigne J. Studies of cyclic AMP action using mutant tissue culture cells. In Vitro. 14: 140-5. PMID 23989 DOI: 10.1007/BF02618180  1
1977 Gold WM, Meyers GL, Dain DS, Miller RL, Bourne HR. Changes in airway mast cells and histamine caused by antigen aerosol in allergic dogs. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 43: 271-5. PMID 893281  1
1977 Johnson GL, Bourne HR. Influence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochemical and Biophysical Research Communications. 78: 792-8. PMID 199187 DOI: 10.1016/0006-291X(77)90249-2  1
1977 Wigglesworth NM, Mastro A, Bourne HR, Roxengurt E. Cyclic AMP-binding proteins in normal and virus-transformed fibroblasts. Archives of Biochemistry and Biophysics. 180: 258-63. PMID 195521 DOI: 10.1016/0003-9861(77)90036-4  1
1977 Hochman J, Bourne HR, Coffino P, Insel PA, Krasny L, Melmon KL. Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 1167-71. PMID 191831  1
1976 Insel PA, Maguire ME, Gilman AG, Bourne HR, Coffino P, Melmon KL. Beta adrenergic receptors and adenylate cyclase: products of separate genes? Molecular Pharmacology. 12: 1062-9. PMID 187924  1
1976 Coffino P, Bourne HR, Friedrich U, Hochman J, Insel PA, Lemaire I, Melmon KL, Tomkins GM. Molecular mechanisms of cyclic AMP action: a genetic approach. Recent Progress in Hormone Research. 32: 669-84. PMID 183250  1
1975 Hochman J, Insel PA, Bourne HR, Coffino P, Tomkins GM. A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 72: 5051-5. PMID 174091 DOI: 10.1073/pnas.72.12.5051  1
1975 Insel PA, Bourne HR, Coffino P, Tomkins GM. Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (New York, N.Y.). 190: 896-8. PMID 171770  1
1975 Coffino P, Bourne HR, Tomkins GM. Mechanism of lymphoma cell death induced by cyclic AMP. The American Journal of Pathology. 81: 199-204. PMID 170834  1
1975 Bourne HR, Coffino P, Tomkins GM. Somatic genetic analysis of cyclic AMP action: characterization of unresponsive mutants. Journal of Cellular Physiology. 85: 611-20. PMID 167037 DOI: 10.1002/jcp.1040850313  1
1975 Coffino P, Bourne HR, Tomkins GM. Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants. Journal of Cellular Physiology. 85: 603-10. PMID 167036 DOI: 10.1002/jcp.1040850312  1
1975 Bourne HR, Coffino P, Melmon KL, Tomkins GM, Weinstein Y. Genetic analysis of cyclic AMP in a mammalian cell. Advances in Cyclic Nucleotide Research. 5: 771-86. PMID 165697  1
1975 Bourne HR, Coffino P, Tomkins GM. Selection of a variant lymphoma cell deficient in adenylate cyclase. Science (New York, N.Y.). 187: 750-2. PMID 163487  1
1974 Weinstein Y, Chambers DA, Bourne HR, Melmon KL. Cyclic GMP stimulates lymphocyte nucleic acid synthesis. Nature. 251: 352-3. PMID 4372536 DOI: 10.1038/251352a0  1
1974 Webb DR, Bourne HR, Levinson W. A new phosphodiesterase inhibitor in human lymphocytes: N-methyl-isatin-beta-thiosemicarbazone. Biochemical Pharmacology. 23: 1663-7. PMID 4367956 DOI: 10.1016/0006-2952(74)90380-3  1
1973 Bourne HR, Tomkins GM, Dion S. Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase. Science (New York, N.Y.). 181: 952-4. PMID 4354229  1
1973 Daniel V, Bourne HR, Tomkins GM. Altered metabolism and endogenous cyclic AMP in cultured cells deficient in cyclic AMP-binding proteins. Nature: New Biology. 244: 167-9. PMID 4353421  1
1973 Bourne HR. Cholera enterotoxin: failure of anti-inflammatory agents to prevent cyclic AMP accumulation. Nature. 241: 399. PMID 4349561 DOI: 10.1038/241399a0  1
1973 Lichtenstein LM, Henney CS, Bourne HR, Greenough WB. Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. The Journal of Clinical Investigation. 52: 691-7. PMID 4119467 DOI: 10.1172/JCI107230  1
1971 Bourne HR. The placebo--a poorly understood and neglected therapeutic agent. Rational Drug Therapy. 5: 1-6. PMID 5111095  1
1971 Bourne HR, Lehrer RI, Cline MJ, Melmon KL. Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. The Journal of Clinical Investigation. 50: 920-9. PMID 4323128 DOI: 10.1172/JCI106564  1
1970 Bourne HR, Thomson PD, Melmon KL. Diagnosis and treatment of beta-adrenergic receptor hyperresponsiveness. A critical appraisal. Archives of Internal Medicine. 125: 1063-6. PMID 4378135 DOI: 10.1001/archinte.1970.00310060141020  1
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