Charles Russell Middaugh - Publications

Affiliations: 
Pharmaceutical Chemistry The University of Kansas, USA 
Area:
Macromolecule and Vaccine Stabilization
Website:
https://pharmacy.ku.edu/russ-middaugh

234 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Arora J, Hu Y, Esfandiary R, Sathish HA, Bishop SM, Joshi SB, Middaugh CR, Volkin DB, Weis DD. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity. Mabs. 0. PMID 27560842 DOI: 10.1080/19420862.2016.1222342  1
2016 Lee BL, Kuczera K, Middaugh CR, Jas GS. Publisher's Note: "Permeation of the three aromatic dipeptides through lipid bilayers: Experimental and computational study" [J. Chem. Phys. 144, 245103 (2016)]. The Journal of Chemical Physics. 145: 059902. PMID 27497582 DOI: 10.1063/1.4960183  0.32
2016 Kalonia C, Toprani V, Toth RT, Wahome N, Gabel I, Middaugh CR, Volkin DB. Effects of Protein Conformation, Apparent Solubility, and Protein-Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1 Monoclonal Antibody. The Journal of Physical Chemistry. B. PMID 27380437 DOI: 10.1021/acs.jpcb.6b03878  1
2016 Lee BL, Kuczera K, Middaugh CR, Jas GS. Permeation of the three aromatic dipeptides through lipid bilayers: Experimental and computational study. The Journal of Chemical Physics. 144: 245103. PMID 27369545 DOI: 10.1063/1.4954241  1
2016 Toprani VM, Joshi SB, Kueltzo LA, Schwartz RM, Middaugh CR, Volkin DB. A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development. Journal of Pharmaceutical Sciences. PMID 27368120 DOI: 10.1016/j.xphs.2016.05.021  1
2016 Jas GS, Middaugh CR, Kuczera K. Probing Selection Mechanism of the Most Favorable Conformation of a Dipeptide in Chaotropic and Kosmotropic Solution. The Journal of Physical Chemistry. B. PMID 27328987 DOI: 10.1021/acs.jpcb.6b04528  1
2016 Wahome N, Cooper A, Thapa P, Choudhari S, Gao FP, Volkin DB, Middaugh CR. Production of Well-Characterized Virus-like Particles in an Escherichia coli-Based Expression Platform for Preclinical Vaccine Assessments. Methods in Molecular Biology (Clifton, N.J.). 1404: 437-57. PMID 27076315 DOI: 10.1007/978-1-4939-3389-1_29  1
2016 Wahome N, Hickey JM, Volkin DB, Middaugh CR. Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates. Methods in Molecular Biology (Clifton, N.J.). 1404: 393-421. PMID 27076313 DOI: 10.1007/978-1-4939-3389-1_27  1
2016 Hickey JM, Sahni N, Toth RT, Kumru OS, Joshi SB, Middaugh CR, Volkin DB. Challenges and opportunities of using liquid chromatography and mass spectrometry methods to develop complex vaccine antigens as pharmaceutical dosage forms. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. PMID 27071526 DOI: 10.1016/j.jchromb.2016.04.001  1
2016 Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M. Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. Journal of Pharmaceutical Sciences. 105: 1444-53. PMID 27019961 DOI: 10.1016/j.xphs.2016.02.010  1
2016 Wahome N, Sully E, Singer C, Thomas JC, Hu L, Joshi SB, Volkin DB, Fang J, Karanicolas J, Jacobs DJ, Mantis NJ, Middaugh CR. Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice. Journal of Pharmaceutical Sciences. PMID 26987947 DOI: 10.1016/j.xphs.2016.02.009  1
2016 Jas GS, Rentchler EC, Słowicka A, Hermansen JR, Johnson CK, Middaugh CR, Kuczera K. Reorientation Motion and Preferential Interactions of a Peptide in Denaturants and Osmolyte. The Journal of Physical Chemistry. B. PMID 26967551 DOI: 10.1021/acs.jpcb.6b00028  1
2016 Kim JH, Joshi SB, Esfandiary R, Iyer V, Bishop SM, Volkin DB, Middaugh CR. Improved Comparative Signature Diagrams to Evaluate Similarity of Storage Stability Profiles of Different IgG1 mAbs. Journal of Pharmaceutical Sciences. PMID 26886311 DOI: 10.1016/j.xphs.2016.01.008  1
2016 Kim JH, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB, Smalter Hall A. Biosimilarity Assessments of Model IgG1-Fc Glycoforms Using a Machine Learning Approach. Journal of Pharmaceutical Sciences. 105: 602-12. PMID 26869422 DOI: 10.1016/j.xphs.2015.10.013  1
2016 More AS, Toprani VM, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 588-601. PMID 26869421 DOI: 10.1016/j.xphs.2015.10.014  1
2016 Okbazghi SZ, More AS, White DR, Duan S, Shah IS, Joshi SB, Middaugh CR, Volkin DB, Tolbert TJ. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. Journal of Pharmaceutical Sciences. 105: 559-74. PMID 26869419 DOI: 10.1016/j.xphs.2015.11.003  1
2015 Gleason C, Yee CK, Masatani P, Middaugh CR, Vance A. Probing Shear Thinning Behaviors of IgG Molecules at the Air-water Interface via Rheological Methods. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 26673996 DOI: 10.1021/acs.langmuir.5b03806  1
2015 Chen X, Choudhari SP, Kumar P, Toth RT, Kim JH, Van Roosmalen ML, Leenhouts K, Middaugh CR, Picking WL, Picking WD. Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles. Journal of Pharmaceutical Sciences. PMID 26422758 DOI: 10.1002/jps.24659  1
2015 Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody. Mabs. 7: 525-39. PMID 25875351 DOI: 10.1080/19420862.2015.1029217  1
2015 Telikepalli S, Shinogle HE, Thapa PS, Kim JH, Deshpande M, Jawa V, Middaugh CR, Narhi LO, Joubert MK, Volkin DB. Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting. Journal of Pharmaceutical Sciences. 104: 1575-91. PMID 25753756 DOI: 10.1002/jps.24379  1
2015 Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW. Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. Journal of Pharmaceutical Sciences. 104: 627-39. PMID 25581103 DOI: 10.1002/jps.24295  1
2015 Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life. Mabs. 7: 84-95. PMID 25524268 DOI: 10.4161/19420862.2014.985494  1
2015 Telikepalli S, Kumru OS, Kim JH, Joshi SB, O'Berry KB, Blake-Haskins AW, Perkins MD, Middaugh CR, Volkin DB. Characterization of the physical stability of a lyophilized IgG1 mAb after accelerated shipping-like stress. Journal of Pharmaceutical Sciences. 104: 495-507. PMID 25522000 DOI: 10.1002/jps.24242  1
2015 Chen X, Choudhari SP, Martinez-Becerra FJ, Kim JH, Dickenson NE, Toth RT, Joshi SB, Greenwood JC, Clements JD, Picking WD, Middaugh CR, Picking WL. Impact of detergent on biophysical properties and immune response of the IpaDB fusion protein, a candidate subunit vaccine against Shigella species. Infection and Immunity. 83: 292-9. PMID 25368115 DOI: 10.1128/IAI.02457-14  1
2015 Kumru OS, Joshi SB, Thapa P, Pheasey N, Bullock PS, Bashiri H, Siska CS, Kerwin BA, He F, Volkin DB, Middaugh CR. Characterization of an oncolytic herpes simplex virus drug candidate. Journal of Pharmaceutical Sciences. 104: 485-94. PMID 25362835 DOI: 10.1002/jps.24211  1
2015 Majumdar R, Middaugh CR, Weis DD, Volkin DB. Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies. Journal of Pharmaceutical Sciences. 104: 327-45. PMID 25354868 DOI: 10.1002/jps.24224  1
2015 Kalonia C, Kumru OS, Prajapati I, Mathaes R, Engert J, Zhou S, Middaugh CR, Volkin DB. Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data. Journal of Pharmaceutical Sciences. 104: 536-47. PMID 25302696 DOI: 10.1002/jps.24156  1
2015 Longo LM, Tenorio CA, Kumru OS, Middaugh CR, Blaber M. A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding. Protein Science : a Publication of the Protein Society. 24: 27-37. PMID 25297559 DOI: 10.1002/pro.2580  1
2015 Choudhari SP, Chen X, Kim JH, Van Roosmalen ML, Greenwood JC, Joshi SB, Picking WD, Leenhouts K, Middaugh CR, Picking WL. Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles. Journal of Pharmaceutical Sciences. 104: 424-32. PMID 24916512 DOI: 10.1002/jps.24047  1
2014 Longo LM, Kumru OS, Middaugh CR, Blaber M. Evolution and design of protein structure by folding nucleus symmetric expansion. Structure (London, England : 1993). 22: 1377-84. PMID 25242458 DOI: 10.1016/j.str.2014.08.008  1
2014 Naik S, Kumru OS, Cullom M, Telikepalli SN, Lindboe E, Roop TL, Joshi SB, Amin D, Gao P, Middaugh CR, Volkin DB, Fisher MT. Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Science : a Publication of the Protein Society. 23: 1461-78. PMID 25043635 DOI: 10.1002/pro.2515  1
2014 Kumru OS, Joshi SB, Smith DE, Middaugh CR, Prusik T, Volkin DB. Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. Biologicals : Journal of the International Association of Biological Standardization. 42: 237-59. PMID 24996452 DOI: 10.1016/j.biologicals.2014.05.007  1
2014 Jas GS, Hegefeld WA, Middaugh CR, Johnson CK, Kuczera K. Detailed microscopic unfolding pathways of an α-helix and a β-hairpin: direct observation and molecular dynamics. The Journal of Physical Chemistry. B. 118: 7233-46. PMID 24897620 DOI: 10.1021/jp500955z  1
2014 Alsenaidy MA, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297. Journal of Pharmaceutical Sciences. 103: 1613-27. PMID 24740840 DOI: 10.1002/jps.23975  0.64
2014 Alsenaidy MA, Jain NK, Kim JH, Middaugh CR, Volkin DB. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles. Frontiers in Pharmacology. 5: 39. PMID 24659968 DOI: 10.3389/fphar.2014.00039  1
2014 Baoum AA, Middaugh CR, Berkland C. DNA complexed with TAT peptide and condensed using calcium possesses unique structural features compared to PEI polyplexes. International Journal of Pharmaceutics. 465: 11-7. PMID 24508553 DOI: 10.1016/j.ijpharm.2014.01.040  1
2014 Telikepalli SN, Kumru OS, Kalonia C, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions. Journal of Pharmaceutical Sciences. 103: 796-809. PMID 24452866 DOI: 10.1002/jps.23839  1
2014 Hickey JM, Holtz KM, Manikwar P, Joshi SB, McPherson CE, Buckland B, Srivastava IK, Middaugh CR, Volkin DB. Mechanism of a decrease in potency for the recombinant influenza A virus hemagglutinin H3 antigen during storage. Journal of Pharmaceutical Sciences. 103: 821-7. PMID 24425059 DOI: 10.1002/jps.23848  1
2014 Khasa H, Kramer R, Maddux N, Hamborg M, Joshi SB, Volkin DB, Middaugh CR. Studies of the aggregation of RNase Sa. Journal of Pharmaceutical Sciences. 103: 395-9. PMID 24382748 DOI: 10.1002/jps.23841  1
2014 Jas GS, Middaugh CR, Kuczera K. Non-exponential kinetics and a complete folding pathway of an α-helical heteropeptide: direct observation and comprehensive molecular dynamics. The Journal of Physical Chemistry. B. 118: 639-47. PMID 24341828 DOI: 10.1021/jp410934g  1
2014 Qi W, Zeng Y, Orgel S, Francon A, Kim JH, Randolph TW, Carpenter JF, Middaugh CR. Preformulation study of highly purified inactivated polio vaccine, serotype 3. Journal of Pharmaceutical Sciences. 103: 140-51. PMID 24282078 DOI: 10.1002/jps.23801  1
2014 Chaudhuri R, Cheng Y, Middaugh CR, Volkin DB. High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability. The Aaps Journal. 16: 48-64. PMID 24174400 DOI: 10.1208/s12248-013-9539-6  1
2014 Bakshi K, Liyanage MR, Volkin DB, Middaugh CR. Fourier transform infrared spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 255-69. PMID 24146410 DOI: 10.1007/978-1-62703-673-3_18  1
2014 Bakshi K, Liyanage MR, Volkin DB, Middaugh CR. Circular dichroism of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 247-53. PMID 24146409 DOI: 10.1007/978-1-62703-673-3_17  1
2014 Liyanage MR, Bakshi K, Volkin DB, Middaugh CR. Fluorescence spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 237-46. PMID 24146408 DOI: 10.1007/978-1-62703-673-3_16  1
2014 Liyanage MR, Bakshi K, Volkin DB, Middaugh CR. Ultraviolet absorption spectroscopy of peptides. Methods in Molecular Biology (Clifton, N.J.). 1088: 225-36. PMID 24146407 DOI: 10.1007/978-1-62703-673-3_15  1
2013 Dickenson NE, Arizmendi O, Patil MK, Toth RT, Middaugh CR, Picking WD, Picking WL. N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD. Biochemistry. 52: 8790-9. PMID 24236510 DOI: 10.1021/bi400755f  1
2013 Fang Y, Gao S, Tai D, Middaugh CR, Fang J. Identification of properties important to protein aggregation using feature selection. Bmc Bioinformatics. 14: 314. PMID 24165390 DOI: 10.1186/1471-2105-14-314  1
2013 Cheng W, Joshi SB, Jain NK, He F, Kerwin BA, Volkin DB, Middaugh CR. Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature. Journal of Pharmaceutical Sciences. 102: 4291-304. PMID 24142544 DOI: 10.1002/jps.23748  1
2013 Kramer RM, Zeng Y, Sahni N, Kueltzo LA, Schwartz RM, Srivastava IK, Crane L, Joshi SB, Volkin DB, Middaugh CR. Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. Journal of Pharmaceutical Sciences. 102: 4305-14. PMID 24129946 DOI: 10.1002/jps.23749  1
2013 Kalonia C, Kumru OS, Kim JH, Middaugh CR, Volkin DB. Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques. Journal of Pharmaceutical Sciences. 102: 4256-67. PMID 24122556 DOI: 10.1002/jps.23738  1
2013 Alsenaidy MA, Kim JH, Majumdar R, Weis DD, Joshi SB, Tolbert TJ, Middaugh CR, Volkin DB. High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation. Journal of Pharmaceutical Sciences. 102: 3942-56. PMID 24114789 DOI: 10.1002/jps.23730  1
2013 Iyer V, Hu L, Schanté CE, Vance D, Chadwick C, Jain NK, Brey RN, Joshi SB, Volkin DB, Andra KK, Bann JG, Mantis NJ, Middaugh CR. Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine. Human Vaccines & Immunotherapeutics. 9: 2362-70. PMID 23925275 DOI: 10.4161/hv.25852  1
2013 Thakkar SV, Sahni N, Joshi SB, Kerwin BA, He F, Volkin DB, Middaugh CR. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies. Protein Science : a Publication of the Protein Society. 22: 1295-305. PMID 23893936 DOI: 10.1002/pro.2316  1
2013 Hamborg M, Kramer R, Schanté CE, Agger EM, Christensen D, Jorgensen L, Foged C, Middaugh CR. The physical stability of the recombinant tuberculosis fusion antigens h1 and h56. Journal of Pharmaceutical Sciences. 102: 3567-78. PMID 23873630 DOI: 10.1002/jps.23669  1
2013 Wang T, Kumru OS, Yi L, Wang YJ, Zhang J, Kim JH, Joshi SB, Middaugh CR, Volkin DB. Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment. Journal of Pharmaceutical Sciences. 102: 2520-37. PMID 23824562 DOI: 10.1002/jps.23645  1
2013 Manikwar P, Majumdar R, Hickey JM, Thakkar SV, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Weis DD, Volkin DB. Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. Journal of Pharmaceutical Sciences. 102: 2136-51. PMID 23620222 DOI: 10.1002/jps.23543  1
2013 Martinez-Becerra FJ, Scobey M, Harrison K, Choudhari SP, Quick AM, Joshi SB, Middaugh CR, Picking WL. Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella. Vaccine. 31: 2667-72. PMID 23602665 DOI: 10.1016/j.vaccine.2013.04.012  1
2013 Majumdar R, Manikwar P, Hickey JM, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Volkin DB, Weis DD. Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody. Biochemistry. 52: 3376-89. PMID 23594236 DOI: 10.1021/bi400232p  1
2013 Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Human Vaccines & Immunotherapeutics. 9: 744-52. PMID 23563512 DOI: 10.4161/hv.22998  1
2013 Fakhari A, Phan Q, Thakkar SV, Middaugh CR, Berkland C. Hyaluronic acid nanoparticles titrate the viscoelastic properties of viscosupplements. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 5123-31. PMID 23514620 DOI: 10.1021/la304575x  1
2013 Choudhari SP, Kramer R, Barta ML, Greenwood JC, Geisbrecht BV, Joshi SB, Picking WD, Middaugh CR, Picking WL. Studies of the conformational stability of invasion plasmid antigen B from Shigella. Protein Science : a Publication of the Protein Society. 22: 666-70. PMID 23494968 DOI: 10.1002/pro.2249  1
2013 Dickenson NE, Choudhari SP, Adam PR, Kramer RM, Joshi SB, Middaugh CR, Picking WL, Picking WD. Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon. Protein Science : a Publication of the Protein Society. 22: 614-27. PMID 23456854 DOI: 10.1002/pro.2245  1
2013 Hu L, Joshi SB, Liyanage MR, Pansalawatta M, Alderson MR, Tate A, Robertson G, Maisonneuve J, Volkin DB, Middaugh CR. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. Journal of Pharmaceutical Sciences. 102: 387-400. PMID 23161162 DOI: 10.1002/jps.23375  1
2013 Iyer V, Maddux N, Hu L, Cheng W, Youssef AK, Winter G, Joshi SB, Volkin DB, Middaugh CR. Comparative signature diagrams to evaluate biophysical data for differences in protein structure across various formulations. Journal of Pharmaceutical Sciences. 102: 43-51. PMID 23160989 DOI: 10.1002/jps.23367  1
2013 Liu J, Blasie CA, Shi S, Joshi SB, Middaugh CR, Volkin DB. Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2). Journal of Pharmaceutical Sciences. 102: 827-41. PMID 23160921 DOI: 10.1002/jps.23360  1
2013 Xiao Y, Zeng Y, Alexander E, Mehta S, Joshi SB, Buchman GW, Volkin DB, Middaugh CR, Isaacs SN. Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge. Vaccine. 31: 319-26. PMID 23153450 DOI: 10.1016/j.vaccine.2012.11.007  0.64
2013 Middaugh CR, Volkin DB, Joshi SB. High throughput screening for stabilizers of vaccine antigens Novel Immune Potentiators and Delivery Technologies For Next Generation Vaccines. 119-143. DOI: 10.1007/978-1-4614-5380-2_6  1
2012 Ciaccio NA, Reynolds TS, Middaugh CR, Laurence JS. Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5). Molecular Pharmaceutics. 9: 3190-9. PMID 23067245 DOI: 10.1021/mp300288n  1
2012 Thakkar SV, Kim JH, Samra HS, Sathish HA, Bishop SM, Joshi SB, Volkin DB, Middaugh CR. Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 101: 4444-57. PMID 23060088 DOI: 10.1002/jps.23332  1
2012 Fang Y, Middaugh CR, Fang J. In silico classification of proteins from acidic and neutral cytoplasms. Plos One. 7: e45585. PMID 23049817 DOI: 10.1371/journal.pone.0045585  1
2012 Majumdar R, Manikwar P, Hickey JM, Arora J, Middaugh CR, Volkin DB, Weis DD. Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody. Journal of the American Society For Mass Spectrometry. 23: 2140-8. PMID 22993047 DOI: 10.1007/s13361-012-0485-9  1
2012 Hu L, Joshi SB, Andra KK, Thakkar SV, Volkin DB, Bann JG, Middaugh CR. Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. Journal of Pharmaceutical Sciences. 101: 4118-28. PMID 22911632 DOI: 10.1002/jps.23294  1
2012 Kim JH, Iyer V, Joshi SB, Volkin DB, Middaugh CR. Improved data visualization techniques for analyzing macromolecule structural changes. Protein Science : a Publication of the Protein Society. 21: 1540-53. PMID 22898970 DOI: 10.1002/pro.2144  1
2012 Kumru OS, Liu J, Ji JA, Cheng W, Wang YJ, Wang T, Joshi SB, Middaugh CR, Volkin DB. Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags. Journal of Pharmaceutical Sciences. 101: 3636-50. PMID 22733600 DOI: 10.1002/jps.23224  1
2012 Thakkar SV, Allegre KM, Joshi SB, Volkin DB, Middaugh CR. An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations. Journal of Pharmaceutical Sciences. 101: 3051-61. PMID 22581726 DOI: 10.1002/jps.23188  1
2012 Thakkar SV, Joshi SB, Jones ME, Sathish HA, Bishop SM, Volkin DB, Middaugh CR. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 3062-77. PMID 22581714 DOI: 10.1002/jps.23187  1
2012 Iyer V, Hu L, Liyanage MR, Esfandiary R, Reinisch C, Meinke A, Maisonneuve J, Volkin DB, Joshi SB, Middaugh CR. Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae. Journal of Pharmaceutical Sciences. 101: 3078-90. PMID 22538529 DOI: 10.1002/jps.23175  1
2012 Trivedi M, Laurence JS, Williams TD, Middaugh CR, Siahaan TJ. Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue. International Journal of Pharmaceutics. 431: 16-25. PMID 22531851 DOI: 10.1016/j.ijpharm.2012.03.051  1
2012 Plieskatt JL, Rezende WC, Olsen CM, Trefethen JM, Joshi SB, Middaugh CR, Hotez PJ, Bottazzi ME. Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies. Human Vaccines & Immunotherapeutics. 8: 765-76. PMID 22495115 DOI: 10.4161/hv.19726  1
2012 Maddux NR, Rosen IT, Hu L, Olsen CM, Volkin DB, Middaugh CR. An improved methodology for multidimensional high-throughput preformulation characterization of protein conformational stability. Journal of Pharmaceutical Sciences. 101: 2017-24. PMID 22447621 DOI: 10.1002/jps.23132  1
2012 Shi S, Liu J, Joshi SB, Krasnoperov V, Gill P, Middaugh CR, Volkin DB. Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA. Journal of Pharmaceutical Sciences. 101: 1969-84. PMID 22411527 DOI: 10.1002/jps.23096  1
2012 Pisal DS, Kosloski MP, Middaugh CR, Bankert RB, Balu-Iyer SV. Native-like aggregates of factor VIII are immunogenic in von Willebrand factor deficient and hemophilia a mice. Journal of Pharmaceutical Sciences. 101: 2055-65. PMID 22388918 DOI: 10.1002/jps.23091  1
2012 Iyer V, Liyanage MR, Shoji Y, Chichester JA, Jones RM, Yusibov V, Joshi SB, Middaugh CR. Formulation development of a plant-derived H1N1 influenza vaccine containing purified recombinant hemagglutinin antigen. Human Vaccines & Immunotherapeutics. 8: 453-64. PMID 22370514 DOI: 10.4161/hv.19106  1
2012 Cheng W, Joshi SB, He F, Brems DN, He B, Kerwin BA, Volkin DB, Middaugh CR. Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. Journal of Pharmaceutical Sciences. 101: 1701-20. PMID 22323186 DOI: 10.1002/jps.23076  1
2012 Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schöneich C, Winter G, Friess W, Crommelin DJ, Carpenter JF. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. Journal of Pharmaceutical Sciences. 101: 946-54. PMID 22170395 DOI: 10.1002/jps.23018  1
2012 Bhambhani A, Kissmann JM, Joshi SB, Volkin DB, Kashi RS, Middaugh CR. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions. Journal of Pharmaceutical Sciences. 101: 1120-35. PMID 22147527 DOI: 10.1002/jps.23008  1
2012 Alsenaidy MA, Wang T, Kim JH, Joshi SB, Lee J, Blaber M, Volkin DB, Middaugh CR. An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Science : a Publication of the Protein Society. 21: 418-32. PMID 22113934 DOI: 10.1002/pro.2008  1
2012 Middaugh CR. Expediting early preformulation studies: High-throughput characterization systems and empirical phase diagrams can speed process Genetic Engineering and Biotechnology News. 32: 42-43. DOI: 10.1089/gen.32.15.16  1
2012 Bhambhani A, Thakkar S, Joshi SB, Middaugh CR. A formulation method to improve the physical stability of macromolecular-based drug products Therapeutic Protein Drug Products: Practical Approaches to Formulation in the Laboratory, Manufacturing, and the Clinic. 13-45. DOI: 10.1016/B978-1-907568-18-3.50002-6  1
2011 Mach H, Middaugh CR. Ultraviolet spectroscopy as a tool in therapeutic protein development. Journal of Pharmaceutical Sciences. 100: 1214-27. PMID 24081462 DOI: 10.1002/jps.22385  1
2011 Hu L, Olsen C, Maddux N, Joshi SB, Volkin DB, Middaugh CR. Investigation of protein conformational stability employing a multimodal spectrometer. Analytical Chemistry. 83: 9399-405. PMID 22047496 DOI: 10.1021/ac201995c  1
2011 Khondee S, Olsen CM, Zeng Y, Middaugh CR, Berkland C. Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2). Biomacromolecules. 12: 3880-94. PMID 21954860 DOI: 10.1021/bm2007967  1
2011 Hu L, Trefethen JM, Zeng Y, Yee L, Ohtake S, Lechuga-Ballesteros D, Warfield KL, Aman MJ, Shulenin S, Unfer R, Enterlein SG, Truong-Le V, Volkin DB, Joshi SB, Middaugh CR. Biophysical characterization and conformational stability of Ebola and Marburg virus-like particles. Journal of Pharmaceutical Sciences. 100: 5156-73. PMID 21858822 DOI: 10.1002/jps.22724  1
2011 Kamerzell TJ, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development. Advanced Drug Delivery Reviews. 63: 1118-59. PMID 21855584 DOI: 10.1016/j.addr.2011.07.006  1
2011 Hickey JM, Lovell S, Battaile KP, Hu L, Middaugh CR, Hefty PS. The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily. The Journal of Biological Chemistry. 286: 32606-16. PMID 21775428 DOI: 10.1074/jbc.M111.220574  1
2011 Maddux NR, Joshi SB, Volkin DB, Ralston JP, Middaugh CR. Multidimensional methods for the formulation of biopharmaceuticals and vaccines. Journal of Pharmaceutical Sciences. 100: 4171-97. PMID 21647886 DOI: 10.1002/jps.22618  1
2011 Zeng Y, Ramsey JD, King R, Leviten M, Mcguire R, Volkin DB, Joshi SB, Middaugh CR. Identifying stabilizers of plasmid DNA for pharmaceutical use. Journal of Pharmaceutical Sciences. 100: 904-14. PMID 20740679 DOI: 10.1002/jps.22330  1
2011 Kissmann J, Joshi SB, Haynes JR, Dokken L, Richardson C, Middaugh CR. H1N1 influenza virus-like particles: physical degradation pathways and identification of stabilizers. Journal of Pharmaceutical Sciences. 100: 634-45. PMID 20669328 DOI: 10.1002/jps.22304  1
2011 Middaugh CR, Joshi SB. Spectroscopy of Vaccines Development of Vaccines: From Discovery to Clinical Testing. 263-292. DOI: 10.1002/9781118023648.ch10  1
2010 Markham AP, Barrett BS, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR. Formulation and immunogenicity of a potential multivalent type III secretion system-based protein vaccine. Journal of Pharmaceutical Sciences. 99: 4497-509. PMID 20845449 DOI: 10.1002/jps.22195  1
2010 Barrett BS, Markham AP, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR. Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates. Journal of Pharmaceutical Sciences. 99: 4488-96. PMID 20845448 DOI: 10.1002/jps.22180  1
2010 Cai S, Fang J, Li QS, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension. Biochemistry. 49: 8434-41. PMID 20687591 DOI: 10.1021/bi1007595  1
2010 Volkin DB, Middaugh CR. Vaccines as physically and chemically well-defined pharmaceutical dosage forms. Expert Review of Vaccines. 9: 689-91. PMID 20624039 DOI: 10.1586/erv.10.73  1
2010 Hem SL, HogenEsch H, Middaugh CR, Volkin DB. Preformulation studies--The next advance in aluminum adjuvant-containing vaccines. Vaccine. 28: 4868-70. PMID 20488265 DOI: 10.1016/j.vaccine.2010.05.007  1
2010 Li Y, Middaugh CR, Fang J. A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants. Bmc Bioinformatics. 11: 62. PMID 20109199 DOI: 10.1186/1471-2105-11-62  1
2010 Samra HS, He F, Bhambhani A, Pipkin JD, Zimmerer R, Joshi SB, Middaugh CR. The effects of substituted cyclodextrins on the colloidal and conformational stability of selected proteins. Journal of Pharmaceutical Sciences. 99: 2800-18. PMID 20049940 DOI: 10.1002/jps.22053  1
2010 He F, Joshi SB, Moore DS, Shinogle HE, Ohtake S, Lechuga-Ballesteros D, Martin RA, Truong-Le VL, Middaugh CR. Using spectroscopic and microscopic methods to probe the structural stability of human adenovirus type 4. Human Vaccines. 6: 202-11. PMID 19946219 DOI: 10.4161/hv.6.2.10254  1
2010 Carpenter JF, Randolph TW, Jiskoot W, Crommelin DJ, Middaugh CR, Winter G. Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. Journal of Pharmaceutical Sciences. 99: 2200-8. PMID 19918982 DOI: 10.1002/jps.21989  1
2010 Rao G, Iyer V, Kosloski MP, Pisal DS, Shin E, Middaugh CR, Balu-Iyer SV. Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics. Journal of Pharmaceutical Sciences. 99: 1697-706. PMID 19798762 DOI: 10.1002/jps.21938  1
2010 Joshi SB, Bhambhani A, Zeng Y, Middaugh CR. An Empirical Phase Diagram-High-Throughput Screening Approach to the Characterization and Formulation of Biopharmaceuticals Formulation and Process Development Strategies For Manufacturing Biopharmaceuticals. 173-205. DOI: 10.1002/9780470595886.ch8  1
2009 Cai S, Li QS, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs. Nucleosides, Nucleotides & Nucleic Acids. 28: 485-503. PMID 20183598 DOI: 10.1080/15257770903051031  1
2009 Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 28: 473-84. PMID 20183597 DOI: 10.1080/15257770903044572  1
2009 Esfandiary R, Hunjan JS, Lushington GH, Joshi SB, Middaugh CR. Temperature dependent 2nd derivative absorbance spectroscopy of aromatic amino acids as a probe of protein dynamics. Protein Science : a Publication of the Protein Society. 18: 2603-14. PMID 19827094 DOI: 10.1002/pro.264  1
2009 Markham AP, Jaafar ZA, Kemege KE, Middaugh CR, Hefty PS. Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein. Biochemistry. 48: 10353-61. PMID 19769366 DOI: 10.1021/bi901200y  1
2009 Cai S, He F, Samra HS, de la Maza LM, Bottazzi ME, Joshi SB, Middaugh CR. Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Molecular Pharmaceutics. 6: 1553-61. PMID 19650664 DOI: 10.1021/mp900110q  1
2009 Zheng K, Laurence JS, Kuczera K, Verkhivker G, Middaugh CR, Siahaan TJ. Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chemical Biology & Drug Design. 73: 584-98. PMID 19635050 DOI: 10.1111/j.1747-0285.2009.00818.x  1
2009 Zeng Y, Fan H, Chiueh G, Pham B, Martin R, Lechuga-Ballesteros D, Truong VL, Joshi SB, Middaugh CR. Towards development of stable formulations of a live attenuated bacterial vaccine: a preformulation study facilitated by a biophysical approach. Human Vaccines. 5: 322-31. PMID 19221516 DOI: 10.4161/hv.5.5.7559  1
2009 Trivedi M, Davis RA, Shabaik Y, Roy A, Verkhivker G, Laurence JS, Middaugh CR, Siahaan TJ. The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin. Journal of Pharmaceutical Sciences. 98: 3562-74. PMID 19199298 DOI: 10.1002/jps.21686  1
2009 Ramsey JD, Gill ML, Kamerzell TJ, Price ES, Joshi SB, Bishop SM, Oliver CN, Middaugh CR. Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability. Journal of Pharmaceutical Sciences. 98: 2432-47. PMID 19072858 DOI: 10.1002/jps.21619  1
2009 He F, Joshi SB, Bosman F, Verhaeghe M, Middaugh CR. Structural stability of hepatitis C virus envelope glycoprotein E1: effect of pH and dissociative detergents. Journal of Pharmaceutical Sciences. 98: 3340-57. PMID 19072857 DOI: 10.1002/jps.21657  1
2009 Carpenter JF, Randolph TW, Jiskoot W, Crommelin DJ, Middaugh CR, Winter G, Fan YX, Kirshner S, Verthelyi D, Kozlowski S, Clouse KA, Swann PG, Rosenberg A, Cherney B. Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. Journal of Pharmaceutical Sciences. 98: 1201-5. PMID 18704929 DOI: 10.1002/jps.21530  1
2009 Esfandiary R, Kickhoefer VA, Rome LH, Joshi SB, Middaugh CR. Structural stability of vault particles. Journal of Pharmaceutical Sciences. 98: 1376-86. PMID 18683860 DOI: 10.1002/jps.21508  1
2009 Zheng K, Middaugh CR, Siahaan TJ. Evaluation of the physical stability of the EC5 domain of E-cadherin: Effects of pH, temperature, ionic strength, and disulfide bonds Journal of Pharmaceutical Sciences. 98: 63-73. PMID 18428798 DOI: 10.1002/jps.21418  1
2008 Barrett BS, Picking WL, Picking WD, Middaugh CR. The response of type three secretion system needle proteins MxiH Δ5, BsaLΔ5, and PrgIΔ5 to temperature and pH Proteins: Structure, Function and Genetics. 73: 632-643. PMID 18491382 DOI: 10.1002/prot.22085  1
2008 Ausar SF, Joshi SB, Middaugh CR. Spectroscopic methods for the physical characterization and formulation of nonviral gene delivery systems Methods in Molecular Biology (Clifton, N.J.). 434: 55-80. PMID 18470639 DOI: 10.1007/978-1-60327-248-3_5  1
2008 Brooks AE, Stricker SM, Joshi SB, Kamerzell TJ, Middaugh CR, Lewis RV. Properties of synthetic spider silk fibers based on Argiope aurantia MaSp2. Biomacromolecules. 9: 1506-10. PMID 18457450 DOI: 10.1021/bm701124p  1
2008 Salnikova MS, Middaugh CR, Rytting JH. Stability of lyophilized human growth hormone International Journal of Pharmaceutics. 358: 108-113. PMID 18394830 DOI: 10.1016/j.ijpharm.2008.02.022  1
2008 Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. Biochemistry. 47: 4983-91. PMID 18393535 DOI: 10.1021/bi800175g  1
2008 Kissmann J, Ausar SF, Rudolph A, Braun C, Cape SP, Sievers RE, Federspiel MJ, Joshi SB, Middaugh CR. Stabilization of measles virus for vaccine formulation. Human Vaccines. 4: 350-9. PMID 18382143  1
2008 Peek LJ, Middaugh CR, Berkland C. Nanotechnology in vaccine delivery. Advanced Drug Delivery Reviews. 60: 915-28. PMID 18325628 DOI: 10.1016/j.addr.2007.05.017  1
2008 Kissmann J, Ausar SF, Foubert TR, Brock J, Switzer MH, Detzi EJ, Vedvick TS, Middaugh CR. Physical stabilization of norwalk virus-like particles Journal of Pharmaceutical Sciences. 97: 4208-4218. PMID 18300304 DOI: 10.1002/jps.21315  1
2008 Kamerzell TJ, Ramsey JD, Middaugh CR. Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability. The Journal of Physical Chemistry. B. 112: 3240-50. PMID 18284232 DOI: 10.1021/jp710061a  1
2008 Salnikova MS, Joshi SB, Rytting JH, Warny M, Middaugh CR. Physical characterization of Clostridium difficile toxins and toxoids: effect of the formaldehyde crosslinking on thermal stability Journal of Pharmaceutical Sciences. 97: 3735-3752. PMID 18257030 DOI: 10.1002/jps.21261  1
2008 Salnikova MS, Joshi SB, Rytting JH, Warny M, Middaugh CR. Preformulation studies of Clostridium difficile toxoids A and B Journal of Pharmaceutical Sciences. 97: 4194-4207. PMID 18228584 DOI: 10.1002/jps.21300  1
2008 Kamerzell TJ, Middaugh CR. The complex inter-relationships between protein flexibility and stability. Journal of Pharmaceutical Sciences. 97: 3494-517. PMID 18186490 DOI: 10.1002/jps.21269  1
2008 Markham AP, Birket SE, Picking WD, Picking WL, Middaugh CR. pH sensitivity of type III secretion system tip proteins. Proteins. 71: 1830-42. PMID 18175320 DOI: 10.1002/prot.21864  1
2008 Nonoyama A, Laurence JS, Garriques L, Qi H, Le T, Middaugh CR. A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams Journal of Pharmaceutical Sciences. 97: 2552-2567. PMID 17879973 DOI: 10.1002/jps.21197  1
2008 Joshi SB, Kamerzell TJ, McNown C, Middaugh CR. The interaction of heparin/polyanions with bovine, porcine, and human growth hormone. Journal of Pharmaceutical Sciences. 97: 1368-85. PMID 17705152 DOI: 10.1002/jps.21056  1
2007 Middaugh CR, Ramsey JD. Analysis of cationic-lipid-plasmid-DNA complexes. Analytical Chemistry. 79: 7240-8. PMID 17972398 DOI: 10.1021/ac0719711  1
2007 Kamerzell TJ, Middaugh CR. Two-dimensional correlation spectroscopy reveals coupled immunoglobulin regions of differential flexibility that influence stability. Biochemistry. 46: 9762-73. PMID 17676765 DOI: 10.1021/bi700645k  1
2007 Birket SE, Harrington AT, Espina M, Smith ND, Terry CM, Darboe N, Markham AP, Middaugh CR, Picking WL, Picking WD. Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri. Biochemistry. 46: 8128-37. PMID 17571858 DOI: 10.1021/bi700099c  1
2007 Brandau DT, Joshi SB, Smalter AM, Kim S, Steadman B, Middaugh CR. Stability of the Clostridium botulinum type A neurotoxin complex: an empirical phase diagram based approach. Molecular Pharmaceutics. 4: 571-82. PMID 17552543 DOI: 10.1021/mp0601244  1
2007 Thyagarajapuram N, Olsen D, Middaugh CR. Stabilization of proteins by recombinant human gelatins Journal of Pharmaceutical Sciences. 96: 3304-3315. PMID 17542020 DOI: 10.1002/jps.20980  1
2007 Kamerzell TJ, Joshi SB, McClean D, Peplinskie L, Toney K, Papac D, Li M, Middaugh CR. Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification. Protein Science : a Publication of the Protein Society. 16: 1193-203. PMID 17525467 DOI: 10.1110/ps.062613807  1
2007 Thyagarajapuram N, Olsen D, Middaugh CR. The structure, stability, and complex behavior of recombinant human gelatins Journal of Pharmaceutical Sciences. 96: 3363-3378. PMID 17518362 DOI: 10.1002/jps.21022  1
2007 Li QS, Cai S, Borchardt RT, Fang J, Kuczera K, Middaugh CR, Schowen RL. Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes. Biochemistry. 46: 5798-809. PMID 17447732 DOI: 10.1021/bi700170m  1
2007 Ausar SF, Espina M, Brock J, Thyagarayapuran N, Repetto R, Khandke L, Middaugh CR. High-throughput screening of stabilizers for respirator/syncytial virus: Identification of stabilizers and their effects on the conformational thermostability of viral particles Human Vaccines. 3: 94-103. PMID 17426457  1
2007 Fan H, Vitharana SN, Chen T, O'Keefe D, Middaugh CR. Effects of pH and polyanions on the thermal stability of fibroblast growth factor 20 Molecular Pharmaceutics. 4: 232-240. PMID 17397238 DOI: 10.1021/mp060097h  1
2007 Espina M, Ausar SF, Middaugh CR, Baxter MA, Picking WD, Picking WL. Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems Protein Science. 16: 704-714. PMID 17327391 DOI: 10.1110/ps.062645007  1
2007 Priddy TS, Middaugh CR, Carlson GM. Electrostatic changes in phosphorylase kinase induced by its obligatory allosteric activator Ca2+ Protein Science. 16: 517-527. PMID 17322534 DOI: 10.1110/ps.062577507  1
2007 Salamat-Miller N, Fang J, Seidel CW, Assenov Y, Albrecht M, Middaugh CR. A network-based analysis of polyanion-binding proteins utilizing human protein arrays Journal of Biological Chemistry. 282: 10153-10163. PMID 17276992 DOI: 10.1074/jbc.M610957200  1
2007 Tian F, Middaugh CR, Offerdahl T, Munson E, Sane S, Rytting JH. Spectroscopic evaluation of the stabilization of humanized monoclonal antibodies in amino acid formulations. International Journal of Pharmaceutics. 335: 20-31. PMID 17141436 DOI: 10.1016/j.ijpharm.2006.10.037  1
2007 Fan H, Li H, Zhang M, Middaugh CR. Effects of solutes on empirical phase diagrams of human fibroblast growth factor 1. Journal of Pharmaceutical Sciences. 96: 1490-503. PMID 17094138 DOI: 10.1002/jps.20796  0.72
2007 Derrick T, Grillo AO, Vitharana SN, Jones L, Rexroad J, Shah A, Perkins M, Spitznagel TM, Middaugh CR. Effect of polyanions on the structure and stability of repifermin (keratinocyte growth factor-2). Journal of Pharmaceutical Sciences. 96: 761-76. PMID 17094125 DOI: 10.1002/jps.20797  1
2007 Harn N, Allan C, Oliver C, Middaugh CR. Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability. Journal of Pharmaceutical Sciences. 96: 532-46. PMID 17083094 DOI: 10.1002/jps.20753  1
2007 Peek LJ, Martin TT, Elk Nation C, Pegram SA, Middaugh CR. Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants. Journal of Pharmaceutical Sciences. 96: 547-57. PMID 17080408 DOI: 10.1002/jps.20762  1
2007 Peek LJ, Brey RN, Middaugh CR. A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine. Journal of Pharmaceutical Sciences. 96: 44-60. PMID 16998874 DOI: 10.1002/jps.20675  1
2006 Kamerzell TJ, Unruh JR, Johnson CK, Middaugh CR. Conformational flexibility, hydration and state parameter fluctuations of fibroblast growth factor-10: effects of ligand binding. Biochemistry. 45: 15288-300. PMID 17176051 DOI: 10.1021/bi061712q  1
2006 Salamat-Miller N, Fang J, Seidel CW, Smalter AM, Assenov Y, Albrecht M, Middaugh CR. A network-based analysis of polyanion-binding proteins utilizing yeast protein arrays. Molecular & Cellular Proteomics : McP. 5: 2263-78. PMID 16982674 DOI: 10.1074/mcp.M600240-MCP200  1
2006 Lucas LH, Ersoy BA, Kueltzo LA, Joshi SB, Brandau DT, Thyagarajapuram N, Peek LJ, Middaugh CR. Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions. Protein Science : a Publication of the Protein Society. 15: 2228-43. PMID 16963649 DOI: 10.1110/ps.062133706  1
2006 Ruponen M, Braun CS, Middaugh CR. Biophysical characterization of polymeric and liposomal gene delivery systems using empirical phase diagrams. Journal of Pharmaceutical Sciences. 95: 2101-14. PMID 16883552 DOI: 10.1002/jps.20621  1
2006 Espina M, Ausar SF, Middaugh CR, Picking WD, Picking WL. Spectroscopic and calorimetric analyses of invasion plasmid antigen D (IpaD) from Shigella flexneri reveal the presence of two structural domains Biochemistry. 45: 9219-9227. PMID 16866368 DOI: 10.1021/bi060625v  1
2006 Espina M, Olive AJ, Kenjale R, Moore DS, Ausar SF, Kaminski RW, Oaks EV, Middaugh CR, Picking WD, Picking WL. IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri. Infection and Immunity. 74: 4391-400. PMID 16861624 DOI: 10.1128/IAI.00440-06  1
2006 Guo J, Harn N, Robbins A, Dougherty R, Middaugh CR. Stability of helix-rich proteins at high concentrations. Biochemistry. 45: 8686-96. PMID 16834343 DOI: 10.1021/bi060525p  1
2006 Peek LJ, Brandau DT, Jones LS, Joshi SB, Middaugh CR. A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine. Vaccine. 24: 5839-51. PMID 16735084 DOI: 10.1016/j.vaccine.2006.04.067  1
2006 Rexroad J, Martin TT, McNeilly D, Godwin S, Middaugh CR. Thermal stability of adenovirus type 2 as a function of pH. Journal of Pharmaceutical Sciences. 95: 1469-79. PMID 16724322 DOI: 10.1002/jps.20617  1
2006 Ausar SF, Foubert TR, Hudson MH, Vedvick TS, Middaugh CR. conformational stability and disassembly of norwalk virus-like particles: Effect of ph and temperature Journal of Biological Chemistry. 281: 19478-19488. PMID 16675449 DOI: 10.1074/jbc.M603313200  1
2006 Darboe N, Kenjale R, Picking WL, Picking WD, Middaugh CR. Physical characterization of MxiH and PrgI, the needle component of the type III secretion apparatus from Shigella and Salmonella. Protein Science : a Publication of the Protein Society. 15: 543-52. PMID 16501225 DOI: 10.1110/ps.051733506  1
2006 Fan H, Kashi RS, Middaugh CR. Conformational lability of two molecular chaperones Hsc70 and gp96: effects of pH and temperature. Archives of Biochemistry and Biophysics. 447: 34-45. PMID 16487475 DOI: 10.1016/j.abb.2006.01.012  1
2006 Harrington A, Darboe N, Kenjale R, Picking WL, Middaugh CR, Birket S, Picking WD. Characterization of the interaction of single tryptophan containing mutants of IpaC from Shigella flexneri with phospholipid membranes. Biochemistry. 45: 626-36. PMID 16401091 DOI: 10.1021/bi0512593  1
2006 Purohit VS, Middaugh CR, Balasubramanian SV. Influence of aggregation on immunogenicity of recombinant human factor VIII in hemophilia A mice Journal of Pharmaceutical Sciences. 95: 358-371. PMID 16372314 DOI: 10.1002/jps.20529  1
2006 Rexroad J, Evans RK, Middaugh CR. Effect of pH and ionic strength on the physical stability of adenovirus type 5. Journal of Pharmaceutical Sciences. 95: 237-47. PMID 16372304 DOI: 10.1002/jps.20496  1
2006 Jiang G, Joshi SB, Peek LJ, Brandau DT, Huang J, Ferriter MS, Woodley WD, Ford BM, Mar KD, Mikszta JA, Hwang CR, Ulrich R, Harvey NG, Middaugh CR, Sullivan VJ. Anthrax vaccine powder formulations for nasal mucosal delivery. Journal of Pharmaceutical Sciences. 95: 80-96. PMID 16315230 DOI: 10.1002/jps.20484  1
2006 D'Souza AJM, Hart DS, Middaugh CR, Gehrke SH. Characterization of the changes in secondary structure and architecture of elastin-mimetic triblock polypeptides during thermal gelation Macromolecules. 39: 7084-7091. DOI: 10.1021/ma060915j  1
2006 Kueltzo LA, Middaugh CR. Molten globule-lipid bilayer interactions and their implications for protein transport and aggregation Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability. 287-309. DOI: 10.1007/978-0-387-36063-8_13  1
2005 Tumanova I, Boyer J, Ausar SF, Burzynski J, Rosencrance D, White J, Scheidel J, Parkinson R, Maguire H, Middaugh CR, Weiner D, Green AP. Analytical and biological characterization of supercoiled plasmids purified by various chromatographic techniques. Dna and Cell Biology. 24: 819-31. PMID 16332179 DOI: 10.1089/dna.2005.24.819  1
2005 Ausar SF, Rexroad J, Frolov VG, Look JL, Konar N, Middaugh CR. Analysis of the thermal and pH stability of human respiratory syncytial virus. Molecular Pharmaceutics. 2: 491-9. PMID 16323956 DOI: 10.1021/mp0500465  1
2005 Krogmeier SL, Reddy DS, Vander Velde D, Lushington GH, Siahaan TJ, Middaugh CR, Borchardt RT, Topp EM. Deamidation of model beta-turn cyclic peptides in the solid state. Journal of Pharmaceutical Sciences. 94: 2616-31. PMID 16258986 DOI: 10.1002/jps.20468  1
2005 Harn NR, Jeng YN, Kostelc JG, Middaugh CR. Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil. Journal of Pharmaceutical Sciences. 94: 2487-95. PMID 16200543 DOI: 10.1002/jps.20464  1
2005 Fan H, Ralston J, Dibiase M, Faulkner E, Middaugh CR. Solution behavior of IFN-beta-1a: an empirical phase diagram based approach. Journal of Pharmaceutical Sciences. 94: 1893-911. PMID 16052555 DOI: 10.1002/jps.20410  1
2005 Ramani K, Purohit V, Middaugh CR, Balasubramanian SV. Aggregation kinetics of recombinant human FVIII (rFVIII) Journal of Pharmaceutical Sciences. 94: 2023-2029. PMID 16052549 DOI: 10.1002/jps.20432  1
2005 Ramani K, Purohit VS, Miclea RD, Middaugh CR, Balasubramanian SV. Lipid binding region (2303-2332) is involved in aggregation of recombinant human FVIII (rFVIII) Journal of Pharmaceutical Sciences. 94: 1288-1299. PMID 15858858 DOI: 10.1002/jps.20340  1
2005 Braun CS, Fisher MT, Tomalia DA, Koe GS, Koe JG, Middaugh CR. A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes. Biophysical Journal. 88: 4146-58. PMID 15805171 DOI: 10.1529/biophysj.104.055202  1
2005 Jones LS, Kaufmann A, Middaugh CR. Silicone oil induced aggregation of proteins. Journal of Pharmaceutical Sciences. 94: 918-27. PMID 15736189 DOI: 10.1002/jps.20321  1
2005 Jones LS, Peek LJ, Power J, Markham A, Yazzie B, Middaugh CR. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. The Journal of Biological Chemistry. 280: 13406-14. PMID 15684430 DOI: 10.1074/jbc.M500687200  1
2005 Braun CS, Vetro JA, Tomalia DA, Koe GS, Koe JG, Middaugh CR. Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. Journal of Pharmaceutical Sciences. 94: 423-36. PMID 15614818 DOI: 10.1002/jps.20251  1
2005 Kueltzo LA, Middaugh CR. Polycationic Peptides and Proteins in Drug Delivery: Focus on Nonclassical Transport Drug Delivery: Principles and Applications. 279-304. DOI: 10.1002/0471475734.ch13  1
2005 Hart DS, D'Souza AJM, Middaugh CR, Gehrke SH. Gelation and phase equilibria of responsive elastin-mimetic triblock hydrogels Aiche Annual Meeting, Conference Proceedings. 14111-14115.  1
2004 Derrick TS, Kashi RS, Durrani M, Jhingan A, Middaugh CR. Effect of metal cations on the conformation and inactivation of recombinant human factor VIII. Journal of Pharmaceutical Sciences. 93: 2549-57. PMID 15349964 DOI: 10.1002/jps.20167  1
2004 Jones LS, Yazzie B, Middaugh CR. Polyanions and the proteome Molecular and Cellular Proteomics. 3: 746-769. PMID 15143156 DOI: 10.1074/mcp.R400008-MCP200  1
2004 Stotz CE, Borchardt RT, Middaugh CR, Siahaan TJ, Vander Velde D, Topp EM. Secondary structure of a dynamic type I' β-hairpin peptide Journal of Peptide Research. 63: 371-382. PMID 15102055 DOI: 10.1111/j.1399-3011.2004.00129.x  1
2004 Wiethoff CM, Koe JG, Koe GS, Middaugh CR. Compositional effects of cationic lipid/DNA delivery systems on transgene expression in cell culture. Journal of Pharmaceutical Sciences. 93: 108-23. PMID 14648641 DOI: 10.1002/jps.10519  1
2004 Hart DS, D'Souza AJM, Middaugh CR, Gehrke SH. Thermally gelling, thermally responsive elastin-mimetic triblock hydrogels Aiche Annual Meeting, Conference Proceedings. 8385-8387.  1
2003 Lobo BA, Vetro JA, Suich DM, Zuckermann RN, Middaugh CR. Structure/function analysis of peptoid/lipitoid:DNA complexes. Journal of Pharmaceutical Sciences. 92: 1905-18. PMID 12950008 DOI: 10.1002/jps.10450  1
2003 Kueltzo LA, Ersoy B, Ralston JP, Middaugh CR. Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: a bGCSF case study. Journal of Pharmaceutical Sciences. 92: 1805-20. PMID 12949999 DOI: 10.1002/jps.10439  0.96
2003 Kueltzo LA, Middaugh CR. Structural characterization of bovine granulocyte colony stimulating factor: effect of temperature and pH. Journal of Pharmaceutical Sciences. 92: 1793-804. PMID 12949998 DOI: 10.1002/jps.10440  1
2003 Kueltzo LA, Middaugh CR. Nonclassical transport proteins and peptides: an alternative to classical macromolecule delivery systems. Journal of Pharmaceutical Sciences. 92: 1754-72. PMID 12949995 DOI: 10.1002/jps.10448  1
2003 Tiyaboonchai W, Woiszwillo J, Middaugh CR. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 19: 191-202. PMID 12885383 DOI: 10.1016/S0928-0987(03)00102-7  1
2003 Choosakoonkriang S, Lobo BA, Koe GS, Koe JG, Middaugh CR. Biophysical characterization of PEI/DNA complexes. Journal of Pharmaceutical Sciences. 92: 1710-22. PMID 12884257 DOI: 10.1002/jps.10437  1
2003 Lobo BA, Koe GS, Koe JG, Middaugh CR. Thermodynamic analysis of binding and protonation in DOTAP/DOPE (1:1): DNA complexes using isothermal titration calorimetry. Biophysical Chemistry. 104: 67-78. PMID 12834828 DOI: 10.1016/S0301-4622(02)00339-3  1
2003 Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles. Journal of Pharmaceutical Sciences. 92: 1272-85. PMID 12761816 DOI: 10.1002/jps.10391  1
2003 Tiyaboonchai W, Woiszwillo J, Sims RC, Middaugh CR. Insulin containing polyethylenimine-dextran sulfate nanoparticles. International Journal of Pharmaceutics. 255: 139-51. PMID 12672610 DOI: 10.1016/S0378-5173(03)00055-3  1
2003 Rexroad J, Wiethoff CM, Green AP, Kierstead TD, Scott MO, Middaugh CR. Structural stability of adenovirus type 5. Journal of Pharmaceutical Sciences. 92: 665-78. PMID 12587128 DOI: 10.1002/jps.10340  1
2003 Braun CS, Jas GS, Choosakoonkriang S, Koe GS, Smith JG, Middaugh CR. The structure of DNA within cationic lipid/DNA complexes. Biophysical Journal. 84: 1114-23. PMID 12547792 DOI: 10.1016/S0006-3495(03)74927-3  1
2003 Brandau DT, Jones LS, Wiethoff CM, Rexroad J, Middaugh CR. Thermal stability of vaccines. Journal of Pharmaceutical Sciences. 92: 218-31. PMID 12532371 DOI: 10.1002/jps.10296  1
2003 Wiethoff CM, Middaugh CR. Barriers to nonviral gene delivery. Journal of Pharmaceutical Sciences. 92: 203-17. PMID 12532370 DOI: 10.1002/jps.10286  1
2003 Choosakoonkriang S, Wiethoff CM, Koe GS, Koe JG, Anchordoquy TJ, Middaugh CR. An infrared spectroscopic study of the effect of hydration on cationic lipid/DNA complexes. Journal of Pharmaceutical Sciences. 92: 115-30. PMID 12486688 DOI: 10.1002/jps.10279  1
2003 Kueltzo LA, Osiecki J, Barker J, Picking WL, Ersoy B, Picking WD, Middaugh CR. Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. The Journal of Biological Chemistry. 278: 2792-8. PMID 12427760 DOI: 10.1074/jbc.M208383200  1
2002 Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. The structural organization of cationic lipid-DNA complexes. The Journal of Biological Chemistry. 277: 44980-7. PMID 12297507 DOI: 10.1074/jbc.M207758200  1
2002 Huang CY, Ma SS, Lee S, Radhakrishnan R, Braun CS, Choosakoonkriang S, Wiethoff CM, Lobo BA, Middaugh CR. Enhancements in gene expression by the choice of plasmid DNA formulations containing neutral polymeric excipients. Journal of Pharmaceutical Sciences. 91: 1371-81. PMID 11977113 DOI: 10.1002/jps.10130  1
2002 Lobo BA, Rogers SA, Choosakoonkriang S, Smith JG, Koe G, Middaugh CR. Differential scanning calorimetric studies of the thermal stability of plasmid DNA complexed with cationic lipids and polymers. Journal of Pharmaceutical Sciences. 91: 454-66. PMID 11835205 DOI: 10.1002/jps.10025  1
2001 Edwards KLT, Kueltzo LA, Fisher MT, Middaugh CR. Complex effects of molecular chaperones on the aggregation and refolding of fibroblast growth factor-1 Archives of Biochemistry and Biophysics. 393: 14-21. PMID 11516157 DOI: 10.1006/abbi.2001.2472  1
2001 Tiyaboonchai W, Woiszwillo J, Middaugh CR. Formulation and characterization of amphotericin B-polyethylenimine-dextran sulfate nanoparticles Journal of Pharmaceutical Sciences. 90: 902-914. PMID 11458338 DOI: 10.1002/jps.1042  1
2001 Wiethoff CM, Smith JG, Koe GS, Middaugh CR. The potential role of proteoglycans in cationic lipid-mediated gene delivery: Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans Journal of Biological Chemistry. 276: 32806-32813. PMID 11443107 DOI: 10.1074/jbc.M007940200  1
2001 Lobo BA, Davis A, Koe G, Smith JG, Middaugh CR. Isothermal titration calorimetric analysis of the interaction between cationic lipids and plasmid DNA Archives of Biochemistry and Biophysics. 386: 95-105. PMID 11361005 DOI: 10.1006/abbi.2000.2196  1
2001 Choosakoonkriang S, Wiethoff CM, Anchordoquy TJ, Koe GS, Smith JG, Middaugh CR. Infrared Spectroscopic Characterization of the Interaction of Cationic Lipids with Plasmid DNA Journal of Biological Chemistry. 276: 8037-8043. PMID 11118456 DOI: 10.1074/jbc.M010592200  1
2000 Kueltzo LA, Middaugh CR. Potential use of non-classical pathways for the transport of macromolecular drugs Expert Opinion On Investigational Drugs. 9: 2039-2050. PMID 11060791  1
2000 Kueltzo LA, Normand N, O'Hare P, Middaugh CR. Conformational lability of herpesvirus protein VP22 Journal of Biological Chemistry. 275: 33213-33221. PMID 10913125 DOI: 10.1074/jbc.M002476200  1
1987 Middaugh CR, Litman GW. Atypical glycosylation of an IgG monoclonal cryoimmunoglobulin. The Journal of Biological Chemistry. 262: 3671-3. PMID 3102493  1
1986 Brandau DT, Lawson EQ, Middaugh CR, Litman GW. The effect of interchain disulfide bond cleavage on the cold induced precipitation of cryoimmunoglobulins. Immunological Investigations. 15: 447-62. PMID 3781575 DOI: 10.3109/08820138609054916  1
1981 Litman GW, Scheffel C, Gerber-Jenson B, Litman R, Middaugh CR. Molecular basis for the temperature-dependent insolubility of cryoglobulins. XII. Anomalous mobility of monoclonal cryoimmunoglobulin heavy chains accompanying polyacrylamide gel electrophoresis in sodium dodecyl sulfate. Immunological Communications. 10: 707-18. PMID 6804373  1
1980 Middaugh CR, Lawson EQ, Litman GW, Tisel WA, Mood DA, Rosenberg A. Thermodynamic basis for the abnormal solubility of monoclonal cryoimmunoglobulins. The Journal of Biological Chemistry. 255: 6532-4. PMID 7190147  1
1980 Litman GW, Gerber-Jenson B, Litman R, Middaugh CR, Scheffel C. Molecular basis for the temperature-dependent insolubility of cryoglobulins--IX. Physicochemical characterization of an IgG1, kappa monoclonal cryoimmunoglobulin exhibiting marginal low temperature-dependent insolubility. Molecular Immunology. 17: 337-44. PMID 6777663 DOI: 10.1016/0161-5890(80)90054-1  1
1979 Thomas GJ, Prescott B, Middaugh CR, Litman GW. Raman spectra and conformational structures of Fab mu and (Fc)5 mu fragments of cryoglobulin IgM-kappa McE. Biochimica Et Biophysica Acta. 577: 285-90. PMID 110353 DOI: 10.1016/0005-2795(79)90032-1  1
1978 Middaugh CR, Litman GW. Investigations of the molecular basis for the temperature-dependent insolubility of cryoglobulins. VI. Quenching by acrylamide of the intrinsic tryptophan fluorescence of cryoglobulin and non-cryoglobulin IgM proteins. Biochimica Et Biophysica Acta. 535: 33-43. PMID 667117 DOI: 10.1016/0005-2795(78)90030-2  1
1978 Middaugh CR, Oshman RG, Litman GW. Localization of a conformational anomaly to the Fabmu region of a monoclonal IgM cryoglobulin. Clinical and Experimental Immunology. 31: 126-30. PMID 416930  1
1978 Wang AC, Mathur S, Pandey J, Siegel FP, Middaugh CR, Litman GW. Hv(1), a variable-region genetic marker of human immunoglobulin heavy chains. Science (New York, N.Y.). 200: 327-9. PMID 416494  1
1978 Middaugh CR, Gerber-Jenson B, Hurvitz A, Paluszek A, Scheffel C, Litman GW. Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. Proceedings of the National Academy of Sciences of the United States of America. 75: 3440-4. PMID 28525  1
1978 Middaugh CR, Kehoe JM, Prystowsky MB, Gerber-Jenson B, Jenson JC, Litman GW. Molecular basis for the temperature-dependent insolubility of cryoglobulins--IV. Structural studies of the IgM monoclonal cryoglobulin McE. Immunochemistry. 15: 171-87. PMID 25240 DOI: 10.1016/0161-5890(78)90146-3  1
1977 Middaugh CR, Litman GW. Effect of solutes on the cold-induced insolubility of monoclonal cryoimmunoglobulins. The Journal of Biological Chemistry. 252: 8002-6. PMID 914859  1
1977 Middaugh CR, Litman GW. Effect of D2O on the temperature-dependent solubility of cryoglobulin and noncryoglobulin IgM. Febs Letters. 79: 200-2. PMID 891928 DOI: 10.1016/0014-5793(77)80382-7  1
1977 Middaugh CR, Thomas GJ, Prescott B, Aberlin ME, Litman GW. Investigations of the molecular basis for the temperature-dependent insolubility of cryoglobulins. II. Spectroscopic studies of the IgM monoclonal cryoglobulin McE. Biochemistry. 16: 2986-94. PMID 880291  1
1977 Hurvitz AI, MacEwen EG, Middaugh CR, Litman GW. Monoclonal cryoglobulinemia with macroglobulinemia in a dog. Journal of the American Veterinary Medical Association. 170: 511-3. PMID 403167  1
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