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Lea Harrington - Publications

Affiliations: 
Cell Biology University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Website:
http://www.wcb.ed.ac.uk/harrington
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Stock AJ, McDevitt RA, Puligilla C, Wang Y, Zhang Y, Wang K, Sun C, Becker KG, Lehrmann E, Wood WH, Gong Y, Aqdas M, Sung MH, Hoffmann V, Liu C, ... ... Harrington L, et al. Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. Plos Genetics. 18: e1010506. PMID 36441670 DOI: 10.1371/journal.pgen.1010506  0.681
2022 Borges G, Criqui M, Harrington L. Tieing together loose ends: telomere instability in cancer and aging. Molecular Oncology. PMID 35920280 DOI: 10.1002/1878-0261.13299  0.361
2020 Sun C, Wang K, Stock AJ, Gong Y, Demarest TG, Yang B, Giri N, Harrington L, Alter BP, Savage SA, Bohr VA, Liu Y. Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. The Embo Journal. e103420. PMID 32935380 DOI: 10.15252/Embj.2019103420  0.658
2018 Monaghan P, Eisenberg DTA, Harrington L, Nussey D. Understanding diversity in telomere dynamics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335374 DOI: 10.1098/Rstb.2016.0435  0.402
2018 Harrington L, Pucci F. In medio stat virtus: unanticipated consequences of telomere dysequilibrium. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335368 DOI: 10.1098/rstb.2016.0444  0.379
2015 Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu Y. Defective repair of uracil causes telomere defects in mouse hematopoietic cells. The Journal of Biological Chemistry. 290: 5502-11. PMID 25572391 DOI: 10.1074/Jbc.M114.607101  0.688
2015 Fairlie J, Harrington L. Enforced telomere elongation increases the sensitivity of human tumour cells to ionizing radiation. Dna Repair. 25: 54-9. PMID 25484304 DOI: 10.1016/j.dnarep.2014.11.005  0.387
2014 Vasianovich Y, Harrington LA, Makovets S. Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening. Plos Genetics. 10: e1004679. PMID 25329304 DOI: 10.1371/journal.pgen.1004679  0.36
2013 Gardano L, Pucci F, Christian L, Le Bihan T, Harrington L. Telomeres, a busy platform for cell signaling. Frontiers in Oncology. 3: 146. PMID 23772418 DOI: 10.3389/fonc.2013.00146  0.416
2013 Pucci F, Gardano L, Harrington L. Short telomeres in ESCs lead to unstable differentiation. Cell Stem Cell. 12: 479-86. PMID 23561444 DOI: 10.1016/j.stem.2013.01.018  0.317
2013 Wong LH, Unciti-Broceta A, Spitzer M, White R, Tyers M, Harrington L. A yeast chemical genetic screen identifies inhibitors of human telomerase. Chemistry & Biology. 20: 333-40. PMID 23521791 DOI: 10.1016/J.Chembiol.2012.12.008  0.313
2012 Taboski MA, Sealey DC, Dorrens J, Tayade C, Betts DH, Harrington L. Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis. Cell Reports. 1: 91-8. PMID 22832159 DOI: 10.1016/J.Celrep.2011.12.004  0.427
2012 Gardano L, Holland L, Oulton R, Le Bihan T, Harrington L. Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin. Nucleic Acids Research. 40: e36. PMID 22187156 DOI: 10.1093/nar/gkr1243  0.43
2012 Liu Y, Harrington L. Murine Models of Dysfunctional Telomeres and Telomerase Telomerases: Chemistry, Biology, and Clinical Applications. 213-242. DOI: 10.1002/9781118268667.ch9  0.651
2011 Sealey DC, Kostic AD, LeBel C, Pryde F, Harrington L. The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. Bmc Molecular Biology. 12: 45. PMID 22011238 DOI: 10.1186/1471-2199-12-45  0.467
2011 Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. Dna Repair. 10: 1164-73. PMID 21945094 DOI: 10.1016/j.dnarep.2011.09.002  0.342
2010 Sealey DC, Zheng L, Taboski MA, Cruickshank J, Ikura M, Harrington LA. The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Research. 38: 2019-35. PMID 20034955 DOI: 10.1093/nar/gkp1160  0.405
2010 Gardano L, Harrington L. Telomere biology and biochemistry Cellular Senescence and Tumor Suppression. 3-43. DOI: 10.1007/978-1-4419-1075-2_1  0.39
2009 Meznikova M, Erdmann N, Allsopp R, Harrington LA. Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Disease Models & Mechanisms. 2: 620-6. PMID 19841238 DOI: 10.1242/dmm.004069  0.417
2009 Lebel C, Rosonina E, Sealey DC, Pryde F, Lydall D, Maringele L, Harrington LA. Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52. Genetics. 182: 671-84. PMID 19380905 DOI: 10.1534/Genetics.109.102939  0.394
2007 Snow BE, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian V, Squire J, Harrington L. Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Molecular and Cellular Biology. 27: 1017-26. PMID 17130244 DOI: 10.1128/Mcb.01866-06  0.558
2006 Betts DH, Perrault S, Harrington L, King WA. Quantitative analysis of telomerase activity and telomere length in domestic animal clones. Methods in Molecular Biology (Clifton, N.J.). 325: 149-80. PMID 16761726 DOI: 10.1385/1-59745-005-7:149  0.527
2006 Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binné UK, Harrington L, Sicinski P, Bérubé NG, Dyson NJ, Dick FA. The retinoblastoma protein regulates pericentric heterochromatin. Molecular and Cellular Biology. 26: 3659-71. PMID 16612004 DOI: 10.1128/Mcb.26.9.3659-3671.2006  0.343
2006 Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 124: 1155-68. PMID 16564010 DOI: 10.1016/J.Cell.2005.12.044  0.459
2006 Ungrin MD, Harrington L. Strict control of telomerase activation using Cre-mediated inversion. Bmc Biotechnology. 6: 10. PMID 16504006 DOI: 10.1186/1472-6750-6-10  0.433
2005 Goldman F, Bouarich R, Kulkarni S, Freeman S, Du HY, Harrington L, Mason PJ, Londoño-Vallejo A, Bessler M. The effect of TERC haploinsufficiency on the inheritance of telomere length. Proceedings of the National Academy of Sciences of the United States of America. 102: 17119-24. PMID 16284252 DOI: 10.1073/Pnas.0505318102  0.5
2005 Wang JCY, Warner JK, Erdmann N, Lansdorp PM, Harrington L, Dick JE. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 102: 14398-14403. PMID 16172394 DOI: 10.1073/Pnas.0504161102  0.504
2005 Harrington L. Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 493-504. PMID 16132814 DOI: 10.1007/S10577-005-0994-5  0.607
2005 Poderycki MJ, Rome LH, Harrington L, Kickhoefer VA. The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Research. 33: 893-902. PMID 15701761 DOI: 10.1093/nar/gki234  0.378
2004 Mikyas Y, Makabi M, Raval-Fernandes S, Harrington L, Kickhoefer VA, Rome LH, Stewart PL. Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. Journal of Molecular Biology. 344: 91-105. PMID 15504404 DOI: 10.1016/J.Jmb.2004.09.021  0.378
2004 Harrington L. Does the reservoir for self-renewal stem from the ends? Oncogene. 23: 7283-9. PMID 15378088 DOI: 10.1038/Sj.Onc.1207948  0.343
2004 Edmonds D, Breitkreutz BJ, Harrington L. A genome-wide telomere screen in yeast: the long and short of it all. Proceedings of the National Academy of Sciences of the United States of America. 101: 9515-6. PMID 15213325 DOI: 10.1073/Pnas.0403378101  0.459
2004 Liu Y, Snow BE, Kickhoefer VA, Erdmann N, Zhou W, Wakeham A, Gomez M, Rome LH, Harrington L. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Molecular and Cellular Biology. 24: 5314-23. PMID 15169895 DOI: 10.1128/Mcb.24.12.5314-5323.2004  0.738
2004 Oulton R, Harrington L. A human telomerase-associated nuclease. Molecular Biology of the Cell. 15: 3244-56. PMID 15121883 DOI: 10.1091/Mbc.E04-03-0178  0.505
2004 Harrington L. Those dam-aged telomeres! Current Opinion in Genetics & Development. 14: 22-8. PMID 15108801 DOI: 10.1016/J.Gde.2003.12.007  0.465
2004 Erdmann N, Liu Y, Harrington L. Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 6080-5. PMID 15079066 DOI: 10.1073/Pnas.0401580101  0.704
2003 Harrington L. Biochemical aspects of telomerase function. Cancer Letters. 194: 139-54. PMID 12757972 DOI: 10.1016/S0304-3835(02)00701-2  0.541
2003 Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L. Functional conservation of the telomerase protein Est1p in humans. Current Biology : Cb. 13: 698-704. PMID 12699629 DOI: 10.1016/S0960-9822(03)00210-0  0.616
2002 Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proceedings of the National Academy of Sciences of the United States of America. 99: 3597-602. PMID 11904422 DOI: 10.1073/Pnas.062549199  0.694
2002 Harrington L, Robinson MO. Telomere dysfunction: multiple paths to the same end. Oncogene. 21: 592-7. PMID 11850784 DOI: 10.1038/Sj.Onc.1205084  0.504
2001 Beattie TL, Zhou W, Robinson MO, Harrington L. Functional multimerization of the human telomerase reverse transcriptase. Molecular and Cellular Biology. 21: 6151-60. PMID 11509658 DOI: 10.1128/Mcb.21.18.6151-6160.2001  0.737
2001 Kickhoefer VA, Liu Y, Kong LB, Snow BE, Stewart PL, Harrington L, Rome LH. The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. The Journal of Cell Biology. 152: 157-64. PMID 11149928 DOI: 10.1083/Jcb.152.1.157  0.714
2001 Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. Erratum: The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo (Current Biology (2000) 10:22 (1459-1462)) Current Biology. 11. DOI: 10.1016/S0960-9822(01)00264-0  0.668
2000 Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Current Biology : Cb. 10: 1459-62. PMID 11102810 DOI: 10.1016/S0960-9822(00)00805-8  0.753
2000 Beattie TL, Zhou W, Robinson MO, Harrington L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Molecular Biology of the Cell. 11: 3329-40. PMID 11029039 DOI: 10.1091/Mbc.11.10.3329  0.736
2000 Liu Y, Snow BE, Hande MP, Baerlocher G, Kickhoefer VA, Yeung D, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Molecular and Cellular Biology. 20: 8178-84. PMID 11027287 DOI: 10.1128/Mcb.20.21.8178-8184.2000  0.747
2000 Oulton R, Harrington L. Telomeres, telomerase, and cancer: Life on the edge of genomic stability Current Opinion in Oncology. 12: 74-81. PMID 10687733 DOI: 10.1097/00001622-200001000-00013  0.41
1999 Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH. Vaults and telomerase share a common subunit, TEP1 Journal of Biological Chemistry. 274: 32712-32717. PMID 10551828 DOI: 10.1074/jbc.274.46.32712  0.362
1999 Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells Genes and Development. 13: 2388-2399. PMID 10500096 DOI: 10.1101/Gad.13.18.2388  0.445
1998 Beattie TL, Zhou W, Robinson MO, Harrington L. Reconstitution of human telomerase activity in vitro. Current Biology : Cb. 8: 177-80. PMID 9443919 DOI: 10.1016/S0960-9822(98)70067-3  0.752
1997 Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes & Development. 11: 3109-15. PMID 9389643 DOI: 10.1101/Gad.11.23.3109  0.45
1997 Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO. A mammalian telomerase-associated protein. Science (New York, N.Y.). 275: 973-7. PMID 9020079 DOI: 10.1126/Science.275.5302.973  0.537
1995 Harrington L, Hull C, Crittenden J, Greider C. Gel shift and UV cross-linking analysis of Tetrahymena telomerase. The Journal of Biological Chemistry. 270: 8893-901. PMID 7721797 DOI: 10.1074/Jbc.270.15.8893  0.648
1992 Avilion AA, Harrington LA, Greider CW. Tetrahymena telomerase RNA levels increase during macronuclear development. Developmental Genetics. 13: 80-6. PMID 1395145 DOI: 10.1002/Dvg.1020130113  0.682
1991 Harrington LA, Greider CW. Telomerase primer specificity and chromosome healing. Nature. 353: 451-4. PMID 1896088 DOI: 10.1016/0962-8924(92)90136-B  0.688
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