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Virginia A. Zakian - Publications

Affiliations: 
Molecular Biology Princeton University, Princeton, NJ 
Website:
http://www.molbio1.princeton.edu/labs/zakian/
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157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lee RS, Geronimo CL, Liu L, Twarowski JM, Malkova A, Zakian VA. Identification of the nuclear localization signal in the Saccharomyces cerevisiae Pif1 DNA helicase. Plos Genetics. 19: e1010853. PMID 37486934 DOI: 10.1371/journal.pgen.1010853  0.338
2023 Zhou ZX, Follonier C, Lujan SA, Burkholder AB, Zakian VA, Kunkel TA. Pif1 family helicases promote mutation avoidance during DNA replication. Nucleic Acids Research. 50: 12844-12855. PMID 36533450 DOI: 10.1093/nar/gkac1127  0.423
2020 Garcia PD, Zakian VA. A new role for proteins subunits of RNase P: stabilization of the telomerase holoenzyme. Microbial Cell (Graz, Austria). 7: 250-254. PMID 32904320 DOI: 10.15698/Mic2020.09.730  0.405
2020 Garcia PD, Leach RW, Wadsworth GM, Choudhary K, Li H, Aviran S, Kim HD, Zakian VA. Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP. Nature Communications. 11: 2173. PMID 32358529 DOI: 10.1038/S41467-020-15875-9  0.407
2019 Chen CF, Pohl TJ, Chan A, Slocum JS, Zakian VA. Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. Genetics. PMID 31391265 DOI: 10.1534/Genetics.119.302528  0.422
2019 Pohl TJ, Zakian VA. Pif1 family DNA helicases: A helpmate to RNase H? Dna Repair. PMID 31231063 DOI: 10.1016/J.Dnarep.2019.06.004  0.481
2018 Chen CF, Pohl TJ, Pott S, Zakian VA. Two Pif1-family DNA Helicases Cooperate in Centromere Replication and Segregation in . Genetics. PMID 30442759 DOI: 10.1534/Genetics.118.301710  0.548
2018 Geronimo CL, Singh SP, Galletto R, Zakian VA. The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity. Nucleic Acids Research. 46: 8357-8370. PMID 30239884 DOI: 10.1093/Nar/Gky655  0.48
2017 Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA. PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes. Nature Communications. 8: 15025. PMID 28429714 DOI: 10.1038/Ncomms15025  0.555
2016 McDonald KR, Guise AJ, Pourbozorgi-Langroudi P, Cristea IM, Zakian VA, Capra JA, Sabouri N. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. Plos Genetics. 12: e1006238. PMID 27611590 DOI: 10.1371/Journal.Pgen.1006238  0.785
2016 Webb CJ, Zakian VA. Telomerase RNA is more than a DNA template. Rna Biology. 0. PMID 27245259 DOI: 10.1080/15476286.2016.1191725  0.538
2016 Geronimo CL, Zakian VA. Getting it done at the ends: Pif1 family DNA helicases and telomeres. Dna Repair. PMID 27233114 DOI: 10.1016/J.Dnarep.2016.05.021  0.599
2016 Lin KW, Zakian VA. 21st Century Genetics: Mass Spectrometry of Yeast Telomerase. Cold Spring Harbor Symposia On Quantitative Biology. PMID 26763982 DOI: 10.1101/Sqb.2015.80.027656  0.505
2016 Lin C, Gu M, Rice CM, Zakian VA, Ha T. Probing Helicase Dynamics on Nucleic Acids through Fluorescence-Force Measurements Biophysical Journal. 110: 515a. DOI: 10.1016/J.Bpj.2015.11.2754  0.442
2015 Webb CJ, Zakian VA. Telomere les(i/s)ons from a telomerase RNA mutant. Cell Cycle (Georgetown, Tex.). 14: 3769-70. PMID 26697827 DOI: 10.1080/15384101.2015.1105693  0.362
2015 Stundon JL, Zakian VA. Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase. G3 (Bethesda, Md.). PMID 26483010 DOI: 10.1534/G3.115.021139  0.554
2015 Lin KW, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA. Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nature Communications. 6: 8290. PMID 26365526 DOI: 10.1038/Ncomms9290  0.718
2015 Webb CJ, Zakian VA. Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding. Proceedings of the National Academy of Sciences of the United States of America. 112: 11312-7. PMID 26305931 DOI: 10.1073/Pnas.1503157112  0.436
2015 Phillips JA, Chan A, Paeschke K, Zakian VA. The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. Plos Genetics. 11: e1005186. PMID 25906395 DOI: 10.1371/Journal.Pgen.1005186  0.731
2014 Sabouri N, Capra JA, Zakian VA. The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. Bmc Biology. 12: 101. PMID 25471935 DOI: 10.1186/S12915-014-0101-5  0.512
2014 McDonald KR, Sabouri N, Webb CJ, Zakian VA. The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening. Dna Repair. 24: 80-6. PMID 25303777 DOI: 10.1016/J.Dnarep.2014.09.008  0.807
2014 Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife. 3: e02190. PMID 24843019 DOI: 10.7554/Elife.02190  0.518
2014 Bochman ML, Paeschke K, Chan A, Zakian VA. Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity. Cell Reports. 6: 346-56. PMID 24440721 DOI: 10.1016/J.Celrep.2013.12.037  0.619
2014 Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Author response: Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA Elife. DOI: 10.7554/Elife.02190.024  0.467
2013 Webb CJ, Wu Y, Zakian VA. DNA repair at telomeres: keeping the ends intact. Cold Spring Harbor Perspectives in Biology. 5. PMID 23732473 DOI: 10.1101/Cshperspect.A012666  0.595
2013 Di Domenico EG, Mattarocci S, Cimino-Reale G, Parisi P, Cifani N, D'Ambrosio E, Zakian VA, Ascenzioni F. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Research. 41: 6490-500. PMID 23677619 DOI: 10.1093/Nar/Gkt365  0.555
2013 Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. 497: 458-62. PMID 23657261 DOI: 10.1038/Nature12149  0.499
2013 Wu Y, DiMaggio PA, Perlman DH, Zakian VA, Garcia BA. Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. Journal of Proteome Research. 12: 316-27. PMID 23181431 DOI: 10.1021/Pr300408V  0.402
2012 Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nature Reviews. Genetics. 13: 770-80. PMID 23032257 DOI: 10.1038/Nrg3296  0.482
2012 Wellinger RJ, Zakian VA. Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics. 191: 1073-105. PMID 22879408 DOI: 10.1534/Genetics.111.137851  0.515
2012 Sabouri N, McDonald KR, Webb CJ, Cristea IM, Zakian VA. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes & Development. 26: 581-93. PMID 22426534 DOI: 10.1101/Gad.184697.111  0.783
2012 Zakian VA. Telomeres: the beginnings and ends of eukaryotic chromosomes. Experimental Cell Research. 318: 1456-60. PMID 22391099 DOI: 10.1016/J.Yexcr.2012.02.015  0.438
2012 Chisholm KM, Aubert SD, Freese KP, Zakian VA, King MC, Welcsh PL. A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1. Plos One. 7: e30748. PMID 22347400 DOI: 10.1371/Journal.Pone.0030748  0.318
2012 Webb CJ, Zakian VA. Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. Genes & Development. 26: 82-91. PMID 22215813 DOI: 10.1101/Gad.181826.111  0.467
2011 Wu Y, Zakian VA. The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro. Proceedings of the National Academy of Sciences of the United States of America. 108: 20362-9. PMID 21969561 DOI: 10.1073/Pnas.1100281108  0.559
2011 Bochman ML, Judge CP, Zakian VA. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Molecular Biology of the Cell. 22: 1955-9. PMID 21670310 DOI: 10.1091/Mbc.E11-01-0045  0.407
2011 Paeschke K, Capra JA, Zakian VA. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell. 145: 678-91. PMID 21620135 DOI: 10.1016/J.Cell.2011.04.015  0.505
2011 Tuzon CT, Wu Y, Chan A, Zakian VA. The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro. Plos Genetics. 7: e1002060. PMID 21573139 DOI: 10.1371/Journal.Pgen.1002060  0.524
2010 McGee JS, Phillips JA, Chan A, Sabourin M, Paeschke K, Zakian VA. Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nature Structural & Molecular Biology. 17: 1438-45. PMID 21057524 DOI: 10.1038/Nsmb.1947  0.806
2010 Fachinetti D, Bermejo R, Cocito A, Minardi S, Katou Y, Kanoh Y, Shirahige K, Azvolinsky A, Zakian VA, Foiani M. Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Molecular Cell. 39: 595-605. PMID 20797631 DOI: 10.1016/J.Molcel.2010.07.024  0.754
2010 Capra JA, Paeschke K, Singh M, Zakian VA. G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae. Plos Computational Biology. 6: e1000861. PMID 20676380 DOI: 10.1371/Journal.Pcbi.1000861  0.542
2010 Paeschke K, McDonald KR, Zakian VA. Telomeres: structures in need of unwinding. Febs Letters. 584: 3760-72. PMID 20637196 DOI: 10.1016/J.Febslet.2010.07.007  0.796
2010 Boulé JB, Zakian VA. Characterization of the helicase activity and anti-telomerase properties of yeast Pif1p in vitro. Methods in Molecular Biology (Clifton, N.J.). 587: 359-76. PMID 20225162 DOI: 10.1007/978-1-60327-355-8_25  0.807
2010 Bochman ML, Sabouri N, Zakian VA. Unwinding the functions of the Pif1 family helicases. Dna Repair. 9: 237-49. PMID 20097624 DOI: 10.1016/J.Dnarep.2010.01.008  0.405
2010 Wu Y, Zakian VA. Identity crisis when telomeres left unprotected. Journal of Molecular Cell Biology. 2: 14-6. PMID 19805416 DOI: 10.1093/Jmcb/Mjp031  0.584
2009 Zakian VA. The ends have arrived. Cell. 139: 1038-40. PMID 20005795 DOI: 10.1016/J.Cell.2009.11.033  0.469
2009 Azvolinsky A, Giresi PG, Lieb JD, Zakian VA. Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. Molecular Cell. 34: 722-34. PMID 19560424 DOI: 10.1016/J.Molcel.2009.05.022  0.725
2009 Ribeyre C, Lopes J, Boulé JB, Piazza A, Guédin A, Zakian VA, Mergny JL, Nicolas A. The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. Plos Genetics. 5: e1000475. PMID 19424434 DOI: 10.1371/Journal.Pgen.1000475  0.476
2008 Chan A, Boulé JB, Zakian VA. Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. Plos Genetics. 4: e1000236. PMID 18949040 DOI: 10.1371/Journal.Pgen.1000236  0.764
2008 Pinter SF, Aubert SD, Zakian VA. The Schizosaccharomyces pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA. Molecular and Cellular Biology. 28: 6594-608. PMID 18725402 DOI: 10.1128/Mcb.00191-08  0.556
2008 Sabourin M, Zakian VA. ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends in Cell Biology. 18: 337-46. PMID 18502129 DOI: 10.1016/J.Tcb.2008.04.004  0.602
2008 Webb CJ, Zakian VA. Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nature Structural & Molecular Biology. 15: 34-42. PMID 18157149 DOI: 10.1038/Nsmb1354  0.379
2007 Mondoux MA, Zakian VA. Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres. Genetics. 177: 2541-6. PMID 18073447 DOI: 10.1534/Genetics.107.079806  0.48
2007 Mondoux MA, Scaife JG, Zakian VA. Differential nuclear localization does not determine the silencing status of Saccharomyces cerevisiae telomeres. Genetics. 177: 2019-29. PMID 18073421 DOI: 10.1534/Genetics.107.079848  0.422
2007 Boulé JB, Zakian VA. The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates. Nucleic Acids Research. 35: 5809-18. PMID 17720711 DOI: 10.1093/Nar/Gkm613  0.818
2007 Sabourin M, Tuzon CT, Zakian VA. Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Molecular Cell. 27: 550-61. PMID 17656141 DOI: 10.1016/J.Molcel.2007.07.016  0.527
2007 Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA. Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. Plos Genetics. 3: e105. PMID 17590086 DOI: 10.1371/Journal.Pgen.0030105  0.645
2007 Bhaskara V, Dupré A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT. Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Molecular Cell. 25: 647-61. PMID 17349953 DOI: 10.1016/J.Molcel.2007.01.028  0.491
2007 Sabourin M, Tuzon CT, Fisher TS, Zakian VA. A flexible protein linker improves the function of epitope-tagged proteins in Saccharomyces cerevisiae. Yeast (Chichester, England). 24: 39-45. PMID 17192851 DOI: 10.1002/Yea.1431  0.334
2007 Snow BE, Mateyak M, Paderova J, Wakeham A, Iorio C, Zakian V, Squire J, Harrington L. Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Molecular and Cellular Biology. 27: 1017-26. PMID 17130244 DOI: 10.1128/Mcb.01866-06  0.627
2006 Goudsouzian LK, Tuzon CT, Zakian VA. S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Molecular Cell. 24: 603-10. PMID 17188035 DOI: 10.1016/J.Molcel.2006.10.005  0.847
2006 Mateyak MK, Zakian VA. Human PIF helicase is cell cycle regulated and associates with telomerase. Cell Cycle (Georgetown, Tex.). 5: 2796-804. PMID 17172855 DOI: 10.4161/Cc.5.23.3524  0.524
2006 Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, Zakian VA. The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes & Development. 20: 3104-16. PMID 17114583 DOI: 10.1101/Gad.1478906  0.829
2006 Boulé JB, Zakian VA. Roles of Pif1-like helicases in the maintenance of genomic stability. Nucleic Acids Research. 34: 4147-53. PMID 16935874 DOI: 10.1093/Nar/Gkl561  0.837
2006 Mondoux MA, Zakian VA. 10 Telomere Position Effect: Silencing Near the End Cold Spring Harbor Monograph Archive. 45: 261-316. DOI: 10.1101/087969810.45.261  0.392
2006 Sealey DCF, Harrington L, Zakian VA. 28 Telomere DNA Replication, Telomerase, and Human Disease Cold Spring Harbor Monograph Archive. 47: 561-591. DOI: 10.1101/087969766.47.561  0.573
2005 Boulé JB, Vega LR, Zakian VA. The yeast Pif1p helicase removes telomerase from telomeric DNA. Nature. 438: 57-61. PMID 16121131 DOI: 10.1038/Nature04091  0.837
2005 Fisher TS, Zakian VA. Ku: a multifunctional protein involved in telomere maintenance. Dna Repair. 4: 1215-26. PMID 15979949 DOI: 10.1016/J.Dnarep.2005.04.021  0.615
2004 Bessler JB, Zakian VA. The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activity. Genetics. 168: 1205-18. PMID 15579680 DOI: 10.1534/Genetics.104.028035  0.819
2004 Fisher TS, Taggart AK, Zakian VA. Cell cycle-dependent regulation of yeast telomerase by Ku. Nature Structural & Molecular Biology. 11: 1198-205. PMID 15531893 DOI: 10.1038/Nsmb854  0.468
2004 Torres JZ, Schnakenberg SL, Zakian VA. Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Molecular and Cellular Biology. 24: 3198-212. PMID 15060144 DOI: 10.1128/Mcb.24.8.3198-3212.2004  0.712
2004 Torres JZ, Bessler JB, Zakian VA. Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p. Genes & Development. 18: 498-503. PMID 15037547 DOI: 10.1101/Gad.1154704  0.845
2003 Ivessa AS, Lenzmeier BA, Bessler JB, Goudsouzian LK, Schnakenberg SL, Zakian VA. The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. Molecular Cell. 12: 1525-36. PMID 14690605 DOI: 10.1016/S1097-2765(03)00456-8  0.821
2003 Vega LR, Mateyak MK, Zakian VA. Getting to the end: telomerase access in yeast and humans. Nature Reviews. Molecular Cell Biology. 4: 948-59. PMID 14685173 DOI: 10.1038/Nrm1256  0.564
2003 Callahan JL, Andrews KJ, Zakian VA, Freudenreich CH. Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Molecular and Cellular Biology. 23: 7849-60. PMID 14560028 DOI: 10.1128/Mcb.23.21.7849-7860.2003  0.565
2003 Taggart AK, Zakian VA. Telomerase: what are the Est proteins doing? Current Opinion in Cell Biology. 15: 275-80. PMID 12787768 DOI: 10.1016/S0955-0674(03)00040-1  0.562
2003 Alexander MK, Zakian VA. Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast. The Embo Journal. 22: 1688-96. PMID 12660174 DOI: 10.1093/Emboj/Cdg154  0.597
2002 Ivessa AS, Zakian VA. To fire or not to fire: origin activation in Saccharomyces cerevisiae ribosomal DNA. Genes & Development. 16: 2459-64. PMID 12368256 DOI: 10.1101/Gad.1033702  0.546
2002 Taggart AK, Teng SC, Zakian VA. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science (New York, N.Y.). 297: 1023-6. PMID 12169735 DOI: 10.1126/Science.1074968  0.703
2002 Zhou JQ, Qi H, Schulz VP, Mateyak MK, Monson EK, Zakian VA. Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases. Molecular Biology of the Cell. 13: 2180-91. PMID 12058079 DOI: 10.1091/Mbc.02-02-0021  0.604
2002 Ivessa AS, Zhou JQ, Schulz VP, Monson EK, Zakian VA. Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes & Development. 16: 1383-96. PMID 12050116 DOI: 10.1101/Gad.982902  0.64
2002 Tham WH, Zakian VA. Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene. 21: 512-21. PMID 11850776 DOI: 10.1038/Sj.Onc.1205078  0.789
2001 Mangahas JL, Alexander MK, Sandell LL, Zakian VA. Repair of chromosome ends after telomere loss in Saccharomyces. Molecular Biology of the Cell. 12: 4078-89. PMID 11739802 DOI: 10.1091/Mbc.12.12.4078  0.606
2001 Tsukamoto Y, Taggart AK, Zakian VA. The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres. Current Biology : Cb. 11: 1328-35. PMID 11553325 DOI: 10.1016/S0960-9822(01)00372-4  0.52
2001 Alexander MK, Bourns BD, Zakian VA. One-hybrid systems for detecting protein-DNA interactions. Methods in Molecular Biology (Clifton, N.J.). 177: 241-59. PMID 11530610 DOI: 10.1385/1-59259-210-4:241  0.437
2001 Tham WH, Wyithe JS, Ko Ferrigno P, Silver PA, Zakian VA. Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions. Molecular Cell. 8: 189-99. PMID 11511372 DOI: 10.1016/S1097-2765(01)00287-8  0.737
2001 Bessler JB, Torres JZ, Zakian VA. The Pif1p subfamily of helicases: region-specific DNA helicases? Trends in Cell Biology. 11: 60-5. PMID 11166213 DOI: 10.1016/S0962-8924(00)01877-8  0.823
2000 Teng SC, Chang J, McCowan B, Zakian VA. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Molecular Cell. 6: 947-52. PMID 11090632 DOI: 10.1016/S1097-2765(05)00094-8  0.65
2000 de Bruin D, Kantrow SM, Liberatore RA, Zakian VA. Telomere folding is required for the stable maintenance of telomere position effects in yeast. Molecular and Cellular Biology. 20: 7991-8000. PMID 11027269 DOI: 10.1128/Mcb.20.21.7991-8000.2000  0.564
2000 Zhou J, Monson EK, Teng SC, Schulz VP, Zakian VA. Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science (New York, N.Y.). 289: 771-4. PMID 10926538 DOI: 10.1126/Science.289.5480.771  0.72
2000 Qi H, Zakian VA. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein. Genes & Development. 14: 1777-88. PMID 10898792 DOI: 10.1101/Gad.14.14.1777  0.59
2000 Ivessa AS, Zhou JQ, Zakian VA. The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell. 100: 479-89. PMID 10693764 DOI: 10.1016/S0092-8674(00)80683-2  0.613
2000 Tham WH, Zakian VA. Telomeric tethers. Nature. 403: 34-5. PMID 10638738 DOI: 10.1038/47385  0.701
2000 Balakumaran BS, Freudenreich CH, Zakian VA. CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae. Human Molecular Genetics. 9: 93-100. PMID 10587583 DOI: 10.1093/Hmg/9.1.93  0.433
1999 Teng SC, Zakian VA. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Molecular and Cellular Biology. 19: 8083-93. PMID 10567534 DOI: 10.1128/Mcb.19.12.8083  0.698
1998 Stavenhagen JB, Zakian VA. Yeast telomeres exert a position effect on recombination between internal tracts of yeast telomeric DNA. Genes & Development. 12: 3044-58. PMID 9765206 DOI: 10.1101/Gad.12.19.3044  0.577
1998 Bourns BD, Alexander MK, Smith AM, Zakian VA. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Molecular and Cellular Biology. 18: 5600-8. PMID 9710643 DOI: 10.1128/Mcb.18.9.5600  0.519
1998 Freudenreich CH, Kantrow SM, Zakian VA. Expansion and length-dependent fragility of CTG repeats in yeast. Science (New York, N.Y.). 279: 853-6. PMID 9452383 DOI: 10.1126/Science.279.5352.853  0.457
1997 Monson EK, de Bruin D, Zakian VA. The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. Proceedings of the National Academy of Sciences of the United States of America. 94: 13081-6. PMID 9371803 DOI: 10.1073/Pnas.94.24.13081  0.445
1997 Freudenreich CH, Stavenhagen JB, Zakian VA. Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome. Molecular and Cellular Biology. 17: 2090-8. PMID 9121457 DOI: 10.1128/Mcb.17.4.2090  0.439
1996 Zakian VA. Telomere functions: lessons from yeast. Trends in Cell Biology. 6: 29-33. PMID 15157529 DOI: 10.1016/0962-8924(96)81035-X  0.571
1996 Zakian VA. Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annual Review of Genetics. 30: 141-72. PMID 8982452 DOI: 10.1146/Annurev.Genet.30.1.141  0.497
1996 Lin JJ, Zakian VA. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proceedings of the National Academy of Sciences of the United States of America. 93: 13760-5. PMID 8943008 DOI: 10.1073/Pnas.93.24.13760  0.746
1996 Runge KW, Zakian VA. TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Molecular and Cellular Biology. 16: 3094-105. PMID 8649421 DOI: 10.1128/Mcb.16.6.3094  0.79
1996 Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, Martin GM. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Human Genetics. 97: 750-4. PMID 8641691 DOI: 10.1007/Bf02346184  0.435
1996 Wellinger RJ, Ethier K, Labrecque P, Zakian VA. Evidence for a new step in telomere maintenance. Cell. 85: 423-33. PMID 8616897 DOI: 10.1016/S0092-8674(00)81120-4  0.583
1995 Wright JH, Zakian VA. Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae. Nucleic Acids Research. 23: 1454-60. PMID 7784196 DOI: 10.1093/Nar/23.9.1454  0.575
1995 Wiley EA, Zakian VA. Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres. Genetics. 139: 67-79. PMID 7705652  0.527
1995 Lin JJ, Zakian VA. An in vitro assay for Saccharomyces telomerase requires EST1. Cell. 81: 1127-35. PMID 7600580 DOI: 10.1016/S0092-8674(05)80017-0  0.607
1995 Zakian VA. Telomeres: beginning to understand the end. Science (New York, N.Y.). 270: 1601-7. PMID 7502069 DOI: 10.1126/Science.270.5242.1601  0.573
1995 Zakian VA. 5 Saccharomyces Telomeres: Function, Structure, and Replication Cold Spring Harbor Monograph Archive. 29: 107-137. DOI: 10.1101/087969457.29.107  0.558
1994 Schulz VP, Zakian VA. The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation. Cell. 76: 145-55. PMID 8287473 DOI: 10.1016/0092-8674(94)90179-1  0.59
1994 Sandell LL, Gottschling DE, Zakian VA. Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proceedings of the National Academy of Sciences of the United States of America. 91: 12061-5. PMID 7991584 DOI: 10.1073/Pnas.91.25.12061  0.739
1994 Stavenhagen JB, Zakian VA. Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. Genes & Development. 8: 1411-22. PMID 7926741 DOI: 10.1101/Gad.8.12.1411  0.465
1994 Lin JJ, Zakian VA. Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro. Nucleic Acids Research. 22: 4906-13. PMID 7800479 DOI: 10.1093/Nar/22.23.4906  0.639
1994 Lin JJ, Zakian VA. Corrigendum: Isolation and characterization of two Saccharomyces cerevisiae genes that encode protein that bind to (TG1-3)(n) single strand telomeric DNA in vitro (Nucleic Acids Research, 1994, 22, 4906-4913)) Nucleic Acids Research. 22: 5516.  0.393
1993 Runge KW, Zakian VA. Saccharomyces cerevisiae linear chromosome stability (lcs) mutants increase the loss rate of artificial and natural linear chromosomes. Chromosoma. 102: 207-17. PMID 8458255 DOI: 10.1007/Bf00387735  0.743
1993 Wellinger RJ, Wolf AJ, Zakian VA. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell. 72: 51-60. PMID 8422682 DOI: 10.1016/0092-8674(93)90049-V  0.57
1993 Wellinger RJ, Wolf AJ, Zakian VA. Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid. Molecular and Cellular Biology. 13: 4057-65. PMID 8321213 DOI: 10.1128/Mcb.13.7.4057  0.581
1993 Sandell LL, Zakian VA. Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell. 75: 729-39. PMID 8242745 DOI: 10.1016/0092-8674(93)90493-A  0.544
1993 Wellinger RJ, Wolf AJ, Zakian VA. Structural and temporal analysis of telomere replication in yeast. Cold Spring Harbor Symposia On Quantitative Biology. 58: 725-32. PMID 7956089 DOI: 10.1101/Sqb.1993.058.01.080  0.414
1992 Sandell LL, Zakian VA. Telomeric position effect in yeast. Trends in Cell Biology. 2: 10-4. PMID 14731632 DOI: 10.1016/0962-8924(92)90138-D  0.44
1992 Wright JH, Gottschling DE, Zakian VA. Saccharomyces telomeres assume a non-nucleosomal chromatin structure. Genes & Development. 6: 197-210. PMID 1737616 DOI: 10.1101/Gad.6.2.197  0.767
1992 Wellinger RJ, Wolf AJ, Zakian VA. Use of non-denaturing Southern hybridization and two dimensional agarose gels to detect putative intermediates in telomere replication in Saccharomyces cerevisiae. Chromosoma. 102: S150-6. PMID 1291236 DOI: 10.1007/Bf02451800  0.561
1991 Runge KW, Wellinger RJ, Zakian VA. Effects of excess centromeres and excess telomeres on chromosome loss rates. Molecular and Cellular Biology. 11: 2919-28. PMID 2038311 DOI: 10.1128/Mcb.11.6.2919  0.769
1990 Gottschling DE, Aparicio OM, Billington BL, Zakian VA. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell. 63: 751-62. PMID 2225075 DOI: 10.1016/0092-8674(90)90141-Z  0.711
1990 Conrad MN, Wright JH, Wolf AJ, Zakian VA. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell. 63: 739-50. PMID 2225074 DOI: 10.1016/0092-8674(90)90140-A  0.523
1990 Wang SS, Zakian VA. Sequencing of Saccharomyces telomeres cloned using T4 DNA polymerase reveals two domains. Molecular and Cellular Biology. 10: 4415-9. PMID 2196453 DOI: 10.1128/Mcb.10.8.4415  0.559
1990 Zakian VA, Runge K, Wang SS. How does the end begin? Formation and maintenance of telomeres in ciliates and yeast. Trends in Genetics : Tig. 6: 12-6. PMID 2183413 DOI: 10.1016/0168-9525(90)90043-6  0.79
1990 Wang SS, Zakian VA. Telomere-telomere recombination provides an express pathway for telomere acquisition. Nature. 345: 456-8. PMID 2111466 DOI: 10.1038/345456A0  0.488
1990 Runge KW, Zakian VA. Properties of the transcriptional enhancer in Saccharomyces cerevisiae telomeres. Nucleic Acids Research. 18: 1783-7. PMID 2110655 DOI: 10.1093/Nar/18.7.1783  0.684
1989 Zakian VA. Structure and function of telomeres. Annual Review of Genetics. 23: 579-604. PMID 2694944 DOI: 10.1146/Annurev.Ge.23.120189.003051  0.528
1989 Sweeney R, Zakian VA. Extrachromosomal elements cause a reduced division potential in nib 1 strains of Saccharomyces cerevisiae. Genetics. 122: 749-57. PMID 2668119  0.345
1989 Runge KW, Zakian VA. Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation. Molecular and Cellular Biology. 9: 1488-97. PMID 2657397 DOI: 10.1128/Mcb.9.4.1488  0.729
1989 Zakian VA, Pluta AF. Telomere formation in yeast. Nature. 338: 468. PMID 2648157 DOI: 10.1038/338468A0  0.452
1989 Wellinger RJ, Zakian VA. Lack of positional requirements for autonomously replicating sequence elements on artificial yeast chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 86: 973-7. PMID 2644653 DOI: 10.1073/Pnas.86.3.973  0.508
1989 Wang SS, Pluta AF, Zakian VA. DNA sequence analysis of newly formed telomeres in yeast. Progress in Clinical and Biological Research. 318: 81-9. PMID 2626440  0.413
1989 Pluta AF, Zakian VA. Recombination occurs during telomere formation in yeast. Nature. 337: 429-33. PMID 2536898 DOI: 10.1038/337429A0  0.587
1988 Zakian VA, Blanton HM. Distribution of telomere-associated sequences on natural chromosomes in Saccharomyces cerevisiae. Molecular and Cellular Biology. 8: 2257-60. PMID 3290654 DOI: 10.1128/Mcb.8.5.2257  0.383
1988 Conrad MN, Zakian VA. Plasmid associations with residual nuclear structures in Saccharomyces cerevisiae. Current Genetics. 13: 291-7. PMID 2839303 DOI: 10.1007/Bf00424422  0.417
1988 Gottschling DE, Zakian VA. Dna-Protein Interactions at Telomeres in Ciliated Protozoans Advances in Molecular and Cell Biology. 2: 291-307. DOI: 10.1016/S1569-2558(08)60438-5  0.779
1986 Zakian VA, Blanton HM, Wetzel L. Distribution of telomere-associated sequences in yeast. Basic Life Sciences. 40: 493-8. PMID 3551920 DOI: 10.1007/978-1-4684-5251-8_37  0.426
1986 Gottschling DE, Zakian VA. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell. 47: 195-205. PMID 3094961 DOI: 10.1016/0092-8674(86)90442-3  0.763
1986 Zakian VA, Blanton HM, Wetzel L, Dani GM. Size threshold for Saccharomyces cerevisiae chromosomes: generation of telocentric chromosomes from an unstable minichromosome. Molecular and Cellular Biology. 6: 925-32. PMID 3022139 DOI: 10.1128/Mcb.6.3.925  0.441
1985 Zakian VA, Blanton HM, Dani GM. Formation and stability of linear plasmids in a recombination deficient strain of yeast. Current Genetics. 9: 441-5. PMID 3916729 DOI: 10.1007/Bf00434048  0.614
1984 Pluta AF, Dani GM, Spear BB, Zakian VA. Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA. Proceedings of the National Academy of Sciences of the United States of America. 81: 1475-9. PMID 6324194 DOI: 10.1073/Pnas.81.5.1475  0.604
1983 Roth GE, Blanton HM, Hager LJ, Zakian VA. Isolation and characterization of sequences from mouse chromosomal DNA with ARS function in yeasts. Molecular and Cellular Biology. 3: 1898-908. PMID 6361521  0.506
1983 Zakian VA. Control of chromosome behaviour in yeast. Nature. 305: 275. PMID 6353242 DOI: 10.1038/305275A0  0.324
1983 Dani GM, Zakian VA. Mitotic and meiotic stability of linear plasmids in yeast. Proceedings of the National Academy of Sciences of the United States of America. 80: 3406-10. PMID 6344082 DOI: 10.1073/Pnas.80.11.3406  0.54
1982 Zakian VA, Kupfer DM. Replication and segregation of an unstable plasmid in yeast. Plasmid. 8: 15-28. PMID 6755509 DOI: 10.1016/0147-619X(82)90037-3  0.599
1982 Zakian VA, Scott JF. Construction, replication, and chromatin structure of TRP1 RI circle, a multiple-copy synthetic plasmid derived from Saccharomyces cerevisiae chromosomal DNA. Molecular and Cellular Biology. 2: 221-32. PMID 6287231  0.576
1981 Zakian VA. Origin of replication from Xenopus laevis mitochondrial DNA promotes high-frequency transformation of yeast Proceedings of the National Academy of Sciences of the United States of America. 78: 3128-3132. PMID 7019920 DOI: 10.1073/Pnas.78.5.3128  0.579
1981 Rabek JP, Zakian VA, Levine AJ. The SV40 a gene product suppresses the adenovirus H5ts125 defect in DNA replication Virology. 109: 290-302. PMID 6259812 DOI: 10.1016/0042-6822(81)90500-6  0.387
1981 Fangman WL, Zakian VA. Genome Structure and Replication Cold Spring Harbor Monograph Archive. 27-58. DOI: 10.1101/87969139.11A.27  0.633
1980 Brewer BJ, Zakian VA, Fangman WL. Replication and meiotic transmission of yeast ribosomal RNA genes Proceedings of the National Academy of Sciences of the United States of America. 77: 6739-6743. PMID 7005901 DOI: 10.1073/Pnas.77.11.6739  0.544
1979 Zakian VA, Brewer BJ, Fangman WL. Replication of each copy of the yeast 2 micron DNA plasmid occurs during the S phase Cell. 17: 923-934. PMID 385147 DOI: 10.1016/0092-8674(79)90332-5  0.603
1976 Zakian VA. Electron microscopic analysis of DNA replication in main band and satellite DNAs of Drosophila virilis Journal of Molecular Biology. 108: 305-331. PMID 1011257 DOI: 10.1016/S0022-2836(76)80123-4  0.39
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