146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. PMID 30022158 DOI: 10.1038/s41586-018-0324-7  0.48
2017 Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Molecular Cell. 67: 162. PMID 28686874 DOI: 10.1016/j.molcel.2017.05.033  0.44
2017 Kibe T, Zimmermann M, de Lange T. TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Molecular Cell. 66: 300. PMID 28431234 DOI: 10.1016/j.molcel.2017.04.004  0.44
2016 Takai H, Jenkinson E, Kabir S, Babul-Hirji R, Najm-Tehrani N, Chitayat DA, Crow YJ, de Lange T. A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes & Development. PMID 27013236 DOI: 10.1101/gad.276873.115  0.64
2016 Kibe T, Zimmermann M, de Lange T. TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Molecular Cell. PMID 26778124 DOI: 10.1016/j.molcel.2015.12.016  1
2015 Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T. Chromothripsis and Kataegis Induced by Telomere Crisis. Cell. 163: 1641-54. PMID 26687355 DOI: 10.1016/j.cell.2015.11.054  1
2015 Tong AS, Stern JL, Sfeir A, Kartawinata M, de Lange T, Zhu XD, Bryan TM. ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Reports. PMID 26586433 DOI: 10.1016/j.celrep.2015.10.041  0.36
2015 Lottersberger F, Karssemeijer RA, Dimitrova N, de Lange T. 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell. 163: 880-93. PMID 26544937 DOI: 10.1016/j.cell.2015.09.057  1
2015 de Lange T. A loopy view of telomere evolution. Frontiers in Genetics. 6: 321. PMID 26539211 DOI: 10.3389/fgene.2015.00321  1
2014 Kabir S, Hockemeyer D, de Lange T. TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Reports. 9: 1273-80. PMID 25453752 DOI: 10.1016/j.celrep.2014.10.014  1
2014 Zimmermann M, Kibe T, Kabir S, de Lange T. TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes & Development. 28: 2477-91. PMID 25344324 DOI: 10.1101/gad.251611.114  1
2014 Doksani Y, de Lange T. The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harbor Perspectives in Biology. 6: a016576. PMID 25228584 DOI: 10.1101/cshperspect.a016576  1
2014 Frescas D, de Lange T. Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection. The Journal of Biological Chemistry. 289: 24180-7. PMID 25056954 DOI: 10.1074/jbc.M114.592592  1
2014 Frescas D, de Lange T. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Molecular and Cellular Biology. 34: 1349-62. PMID 24469404 DOI: 10.1128/MCB.01052-13  1
2014 Frescas D, de Lange T. A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice. Genes & Development. 28: 153-66. PMID 24449270 DOI: 10.1101/gad.233395.113  1
2014 Zimmermann M, de Lange T. 53BP1: pro choice in DNA repair. Trends in Cell Biology. 24: 108-17. PMID 24094932 DOI: 10.1016/j.tcb.2013.09.003  1
2013 Doksani Y, Wu JY, de Lange T, Zhuang X. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell. 155: 345-56. PMID 24120135 DOI: 10.1016/j.cell.2013.09.048  1
2013 Lottersberger F, Bothmer A, Robbiani DF, Nussenzweig MC, de Lange T. Role of 53BP1 oligomerization in regulating double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America. 110: 2146-51. PMID 23345425 DOI: 10.1073/pnas.1222617110  1
2013 Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science (New York, N.Y.). 339: 700-4. PMID 23306437 DOI: 10.1126/science.1231573  1
2012 Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. Plos Genetics. 8: e1002772. PMID 22829774 DOI: 10.1371/journal.pgen.1002772  1
2012 Bosco N, de Lange T. A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma. 121: 465-74. PMID 22790221 DOI: 10.1007/s00412-012-0377-6  1
2012 Wu P, Takai H, de Lange T. Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell. 150: 39-52. PMID 22748632 DOI: 10.1016/j.cell.2012.05.026  1
2012 Davoli T, de Lange T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell. 21: 765-76. PMID 22698402 DOI: 10.1016/j.ccr.2012.03.044  1
2012 Sfeir A, de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science (New York, N.Y.). 336: 593-7. PMID 22556254 DOI: 10.1126/science.1218498  1
2011 Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere protection by TPP1/POT1 requires tethering to TIN2. Molecular Cell. 44: 647-59. PMID 22099311 DOI: 10.1016/j.molcel.2011.08.043  0.44
2011 Davoli T, de Lange T. The causes and consequences of polyploidy in normal development and cancer. Annual Review of Cell and Developmental Biology. 27: 585-610. PMID 21801013 DOI: 10.1146/annurev-cellbio-092910-154234  1
2011 Scherthan H, Sfeir A, de Lange T. Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma. 120: 151-7. PMID 20927532 DOI: 10.1007/s00412-010-0295-4  1
2010 de Lange T. How shelterin solves the telomere end-protection problem. Cold Spring Harbor Symposia On Quantitative Biology. 75: 167-77. PMID 21209389 DOI: 10.1101/sqb.2010.75.017  1
2010 Gong Y, de Lange T. A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion. Molecular Cell. 40: 377-87. PMID 21070964 DOI: 10.1016/j.molcel.2010.10.016  1
2010 Kabir S, Sfeir A, de Lange T. Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle (Georgetown, Tex.). 9: 4061-7. PMID 20948311 DOI: 10.4161/cc.9.20.13579  1
2010 Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T, Boulton SJ. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Molecular Cell. 39: 839-50. PMID 20864032 DOI: 10.1016/j.molcel.2010.08.037  1
2010 Takai H, Xie Y, de Lange T, Pavletich NP. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes & Development. 24: 2019-30. PMID 20801936 DOI: 10.1101/gad.1956410  1
2010 Wu P, van Overbeek M, Rooney S, de Lange T. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Molecular Cell. 39: 606-17. PMID 20619712 DOI: 10.1016/j.molcel.2010.06.031  1
2010 Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell. 141: 81-93. PMID 20371347 DOI: 10.1016/j.cell.2010.01.031  1
2010 Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T. Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science (New York, N.Y.). 327: 1657-61. PMID 20339076 DOI: 10.1126/science.1185100  1
2010 Kibe T, Osawa GA, Keegan CE, de Lange T. Telomere protection by TPP1 is mediated by POT1a and POT1b. Molecular and Cellular Biology. 30: 1059-66. PMID 19995905 DOI: 10.1128/MCB.01498-09  1
2010 Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T. In vivo stoichiometry of shelterin components. The Journal of Biological Chemistry. 285: 1457-67. PMID 19864690 DOI: 10.1074/jbc.M109.038026  1
2009 de Lange T. How telomeres solve the end-protection problem. Science (New York, N.Y.). 326: 948-52. PMID 19965504 DOI: 10.1126/science.1170633  1
2009 Buonomo SB, Wu Y, Ferguson D, de Lange T. Mammalian Rif1 contributes to replication stress survival and homology-directed repair. The Journal of Cell Biology. 187: 385-98. PMID 19948482 DOI: 10.1083/jcb.200902039  1
2009 Dimitrova N, de Lange T. Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Molecular and Cellular Biology. 29: 5552-63. PMID 19667071 DOI: 10.1128/MCB.00476-09  1
2009 Wu P, de Lange T. Human telomerase caught in the act. Cell. 138: 432-4. PMID 19665967 DOI: 10.1016/j.cell.2009.07.018  1
2009 Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103. PMID 19596237 DOI: 10.1016/j.cell.2009.06.021  1
2009 Palm W, Hockemeyer D, Kibe T, de Lange T. Functional dissection of human and mouse POT1 proteins. Molecular and Cellular Biology. 29: 471-82. PMID 18955498 DOI: 10.1128/MCB.01352-08  1
2008 Dimitrova N, Chen YC, Spector DL, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 456: 524-8. PMID 18931659 DOI: 10.1038/nature07433  1
2008 Palm W, de Lange T. How shelterin protects mammalian telomeres. Annual Review of Genetics. 42: 301-34. PMID 18680434 DOI: 10.1146/annurev.genet.41.110306.130350  1
2008 Wu P, de Lange T. No overt nucleosome eviction at deprotected telomeres. Molecular and Cellular Biology. 28: 5724-35. PMID 18625717 DOI: 10.1128/MCB.01764-07  1
2008 Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. Engineered telomere degradation models dyskeratosis congenita. Genes & Development. 22: 1773-85. PMID 18550783 DOI: 10.1101/gad.1679208  1
2008 Konishi A, de Lange T. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes & Development. 22: 1221-30. PMID 18451109 DOI: 10.1101/gad.1634008  1
2008 Chen Y, Yang Y, van Overbeek M, Donigian JR, Baciu P, de Lange T, Lei M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (New York, N.Y.). 319: 1092-6. PMID 18202258 DOI: 10.1126/science.1151804  1
2007 Takai H, Wang RC, Takai KK, Yang H, de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell. 131: 1248-59. PMID 18160036 DOI: 10.1016/j.cell.2007.10.052  1
2007 Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448: 1068-71. PMID 17687332 DOI: 10.1038/nature06065  1
2007 Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural & Molecular Biology. 14: 754-61. PMID 17632522 DOI: 10.1038/nsmb1270  1
2007 Donigian JR, de Lange T. The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex. The Journal of Biological Chemistry. 282: 22662-7. PMID 17561506 DOI: 10.1074/jbc.M702620200  1
2006 Dimitrova N, de Lange T. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes & Development. 20: 3238-43. PMID 17158742 DOI: 10.1101/gad.1496606  1
2006 Lazzerini Denchi E, Celli G, de Lange T. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes & Development. 20: 2648-53. PMID 17015429 DOI: 10.1101/gad.1453606  1
2006 Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, et al. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Experimental Cell Research. 312: 3768-81. PMID 17010969 DOI: 10.1016/j.yexcr.2006.07.019  1
2006 de Lange T. Lasker Laurels for telomerase. Cell. 126: 1017-20. PMID 16990125 DOI: 10.1016/j.cell.2006.09.004  1
2006 Celli GB, Denchi EL, de Lange T. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biology. 8: 885-90. PMID 16845382 DOI: 10.1038/ncb1444  1
2006 Hockemeyer D, Daniels JP, Takai H, de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 126: 63-77. PMID 16839877 DOI: 10.1016/j.cell.2006.04.044  1
2006 van Overbeek M, de Lange T. Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Current Biology : Cb. 16: 1295-302. PMID 16730176 DOI: 10.1016/j.cub.2006.05.022  1
2005 De Lange T. Telomere-related genome instability in cancer. Cold Spring Harbor Symposia On Quantitative Biology. 70: 197-204. PMID 16869754 DOI: 10.1101/sqb.2005.70.032  1
2005 Jacobs JJ, de Lange T. p16INK4a as a second effector of the telomere damage pathway. Cell Cycle (Georgetown, Tex.). 4: 1364-8. PMID 16177573  1
2005 de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes & Development. 19: 2100-10. PMID 16166375 DOI: 10.1101/gad.1346005  1
2005 Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/sj.emboj.7600733  1
2005 Celli GB, de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nature Cell Biology. 7: 712-8. PMID 15968270 DOI: 10.1038/ncb1275  1
2004 Jacobs JJ, de Lange T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Current Biology : Cb. 14: 2302-8. PMID 15620660 DOI: 10.1016/j.cub.2004.12.025  1
2004 Wang RC, Smogorzewska A, de Lange T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell. 119: 355-68. PMID 15507207 DOI: 10.1016/j.cell.2004.10.011  1
2004 Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes & Development. 18: 2108-19. PMID 15342490 DOI: 10.1101/gad.1216004  1
2004 Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. The Journal of Biological Chemistry. 279: 47264-71. PMID 15316005 DOI: 10.1074/jbc.M409047200  1
2004 Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. Plos Biology. 2: E240. PMID 15314656 DOI: 10.1371/journal.pbio.0020240  1
2004 Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes & Development. 18: 1649-54. PMID 15231715 DOI: 10.1101/gad.1215404  1
2004 Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annual Review of Biochemistry. 73: 177-208. PMID 15189140 DOI: 10.1146/annurev.biochem.73.071403.160049  1
2004 Ye JZ, de Lange T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nature Genetics. 36: 618-23. PMID 15133513 DOI: 10.1038/ng1360  1
2004 Loayza D, de Lange T. Telomerase regulation at the telomere: a binary switch. Cell. 117: 279-80. PMID 15109487 DOI: 10.1016/S0092-8674(04)00409-X  1
2004 de Lange T. T-loops and the origin of telomeres. Nature Reviews. Molecular Cell Biology. 5: 323-9. PMID 15071557 DOI: 10.1038/nrm1359  1
2004 Loayza D, Parsons H, Donigian J, Hoke K, de Lange T. DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. The Journal of Biological Chemistry. 279: 13241-8. PMID 14715659 DOI: 10.1074/jbc.M312309200  1
2003 Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Molecular Cell. 12: 1489-98. PMID 14690602 DOI: 10.1016/S1097-2765(03)00478-7  1
2003 Li B, de Lange T. Rap1 affects the length and heterogeneity of human telomeres. Molecular Biology of the Cell. 14: 5060-8. PMID 14565979 DOI: 10.1091/mbc.E03-06-0403  1
2003 Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Current Biology : Cb. 13: 1549-56. PMID 12956959 DOI: 10.1016/S0960-9822(03)00542-6  1
2003 Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Molecular and Cellular Biology. 23: 6533-41. PMID 12944479 DOI: 10.1128/MCB.23.18.6533-6541.2003  1
2003 Loayza D, De Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature. 423: 1013-8. PMID 12768206 DOI: 10.1038/nature01688  1
2002 Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Current Biology : Cb. 12: 1635-44. PMID 12361565 DOI: 10.1016/S0960-9822(02)01179-X  1
2002 Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. The Embo Journal. 21: 4338-48. PMID 12169636 DOI: 10.1093/emboj/cdf433  1
2002 Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science (New York, N.Y.). 295: 2446-9. PMID 11923537 DOI: 10.1126/science.1069523  1
2002 de Lange T. Protection of mammalian telomeres. Oncogene. 21: 532-40. PMID 11850778 DOI: 10.1038/sj.onc.1205080  1
2001 Stansel RM, de Lange T, Griffith JD. T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. The Embo Journal. 20: 5532-40. PMID 11574485 DOI: 10.1093/emboj/20.19.5532  1
2001 Fairall L, Chapman L, Moss H, de Lange T, Rhodes D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Molecular Cell. 8: 351-61. PMID 11545737 DOI: 10.1016/S1097-2765(01)00321-5  1
2001 Hanaoka S, Nagadoi A, Yoshimura S, Aimoto S, Li B, de Lange T, Nishimura Y. NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. Journal of Molecular Biology. 312: 167-75. PMID 11545594 DOI: 10.1006/jmbi.2001.4924  1
2001 De Lange T. Telomere capping - One strand fits all Science. 292: 1075-1076. PMID 11352055 DOI: 10.1126/science.1061032  1
2001 Muñoz-Jordán JL, Cross GA, de Lange T, Griffith JD. t-loops at trypanosome telomeres. The Embo Journal. 20: 579-88. PMID 11157764 DOI: 10.1093/emboj/20.3.579  1
2000 de Lange T, Petrini JH. A new connection at human telomeres: association of the Mre11 complex with TRF2. Cold Spring Harbor Symposia On Quantitative Biology. 65: 265-73. PMID 12760040  1
2000 Scherthan H, Jerratsch M, Li B, Smith S, Hultén M, Lock T, de Lange T. Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Molecular Biology of the Cell. 11: 4189-203. PMID 11102517  1
2000 Smith S, de Lange T. Tankyrase promotes telomere elongation in human cells. Current Biology : Cb. 10: 1299-302. PMID 11069113 DOI: 10.1016/S0960-9822(00)00752-1  1
2000 Zhu XD, Küster B, Mann M, Petrini JH, de Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genetics. 25: 347-52. PMID 10888888 DOI: 10.1038/77139  1
2000 Smogorzewska A, Van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, De Lange T. Control of human telomere length by TRF1 and TRF2 Molecular and Cellular Biology. 20: 1659-1668. PMID 10669743 DOI: 10.1128/MCB.20.5.1659-1668.2000  1
2000 Li B, Oestreich S, De Lange T. Identification of human rap1: Implications for telomere evolution Chemtracts. 13: 877-882.  1
1999 Smith S, de Lange T. Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. Journal of Cell Science. 112: 3649-56. PMID 10523501  1
1999 Bianchi A, Stansel RM, Fairall L, Griffith JD, Rhodes D, De Lange T. TRF1 binds a bipartite telomeric site with extreme spatial flexibility Embo Journal. 18: 5735-5744. PMID 10523316 DOI: 10.1093/emboj/18.20.5735  1
1999 De Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer Cell. 98: 273-275. PMID 10458601 DOI: 10.1016/S0092-8674(00)81955-8  1
1999 Bianchi A, De Lange T. Ku binds telomeric DNA in vitro Journal of Biological Chemistry. 274: 21223-21227. PMID 10409678 DOI: 10.1074/jbc.274.30.21223  1
1999 Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 97: 503-14. PMID 10338214 DOI: 10.1016/S0092-8674(00)80760-6  1
1999 Zhu L, Smith S, de Lange T, Seldin MF. Chromosomal mapping of the tankyrase gene in human and mouse. Genomics. 57: 320-1. PMID 10198177 DOI: 10.1006/geno.1999.5771  1
1999 de Lange T, DePinho RA. Unlimited mileage from telomerase? Science (New York, N.Y.). 283: 947-9. PMID 10075559 DOI: 10.1126/science.283.5404.947  1
1999 Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (New York, N.Y.). 283: 1321-5. PMID 10037601 DOI: 10.1126/science.283.5406.1321  1
1998 Smith S, Giriat I, Schmitt A, de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (New York, N.Y.). 282: 1484-7. PMID 9822378  1
1998 De Lange T. Length of control of human telomeres Cancer Journal From Scientific American. 4: S22-S25. PMID 9619267  1
1998 De Lange T. Ending up with the right partner Nature. 392: 753-754. PMID 9572130 DOI: 10.1038/33790  1
1998 Griffith J, Bianchi A, De Lange T. TRF1 promotes parallel pairing of telomeric tracts in vitro Journal of Molecular Biology. 278: 79-88. PMID 9571035 DOI: 10.1006/jmbi.1998.1686  1
1998 Van Steensel B, Smogorzewska A, De Lange T. TRF2 protects human telomeres from end-to-end fusions Cell. 92: 401-413. PMID 9476899 DOI: 10.1016/S0092-8674(00)80932-0  1
1998 De Lange T. Telomeres and senescence: Ending the debate Science. 279: 334-335. PMID 9454329 DOI: 10.1126/science.279.5349.334  1
1997 Broccoli D, Smogorzewska A, Chong L, de Lange T. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics. 17: 231-5. PMID 9326950 DOI: 10.1038/ng1097-231  1
1997 Bianchi A, Smith S, Chong L, Elias P, de Lange T. TRF1 is a dimer and bends telomeric DNA. The Embo Journal. 16: 1785-94. PMID 9130722 DOI: 10.1093/emboj/16.7.1785  1
1997 Van Steensel B, De Lange T. Control of telomere length by the human telomeric protein TRF1 Nature. 385: 740-743. PMID 9034193 DOI: 10.1038/385740a0  1
1997 Smith S, de Lange T. TRF1, a mammalian telomeric protein. Trends in Genetics : Tig. 13: 21-6. PMID 9009844 DOI: 10.1016/S0168-9525(96)10052-4  1
1997 Broccoli D, Chong L, Oelmann S, Fernald AA, Marziliano N, van Steensel B, Kipling D, Le Beau MM, de Lange T. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Human Molecular Genetics. 6: 69-76. PMID 9002672 DOI: 10.1093/hmg/6.1.69  1
1996 Ludérus MEE, Van Steensel B, Chong L, Sibon OCM, Cremers FFM, De Lange T. Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex Journal of Cell Biology. 135: 867-881. PMID 8922373  1
1996 Broccoli D, Godley LA, Donehower LA, Varmus HE, de Lange T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Molecular and Cellular Biology. 16: 3765-72. PMID 8668193  1
1996 De Lange T. In search of vertebrate telomeric proteins Seminars in Cell and Developmental Biology. 7: 23-29. DOI: 10.1006/scdb.1996.0005  1
1995 Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 9082-6. PMID 7568077 DOI: 10.1073/pnas.92.20.9082  1
1995 Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T. A human telomeric protein. Science (New York, N.Y.). 270: 1663-7. PMID 7502076  1
1994 De Lange T. Activation of telomerase in a human tumor Proceedings of the National Academy of Sciences of the United States of America. 91: 2882-2885. PMID 8159672  1
1994 Hanish JP, Yanowitz JL, De Lange T. Stringent sequence requirements for the formation of human telomeres Proceedings of the National Academy of Sciences of the United States of America. 91: 8861-8865. PMID 8090736 DOI: 10.1073/pnas.91.19.8861  1
1994 Tommerup H, Dousmanis A, De Lange T. Unusual chromatin in human telomeres Molecular and Cellular Biology. 14: 5777-5785. PMID 8065312  1
1993 Saltman D, Morgan R, Cleary ML, de Lange T. Telomeric structure in cells with chromosome end associations Chromosoma. 102: 121-128. PMID 8432193 DOI: 10.1007/BF00356029  1
1993 Cardenas ME, Bianchi A, De Lange T. A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins Genes and Development. 7: 883-894. PMID 7684008  1
1992 De Lange T. Human telomeres are attached to the nuclear matrix Embo Journal. 11: 717-724. PMID 1537344  1
1992 Zhong Z, Shiue L, Kaplan S, De Lange T. A mammalian factor that binds telomeric TTAGGG repeats in vitro Molecular and Cellular Biology. 12: 4834-4843. PMID 1406665  1
1990 de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE. Structure and variability of human chromosome ends. Molecular and Cellular Biology. 10: 518-27. PMID 2300052  1
1987 Timmers HT, de Lange T, Kooter JM, Borst P. Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei. Journal of Molecular Biology. 194: 81-90. PMID 3612801 DOI: 10.1016/0022-2836(87)90717-0  1
1987 Stone J, de Lange T, Ramsay G, Jakobovits E, Bishop JM, Varmus H, Lee W. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Molecular and Cellular Biology. 7: 1697-709. PMID 3299053 DOI: 10.1128/MCB.7.5.1697  1
1986 Bernards A, Van der Ploeg LH, Gibson WC, Leegwater P, Eijgenraam F, De Lange T, Weijers P, Calafat J, Borst P. Rapid change of the repertoire of variant surface glycoprotein genes in trypanosomes by gene duplication and deletion. Journal of Molecular Biology. 190: 1-10. PMID 3783693 DOI: 10.1016/0022-2836(86)90070-7  1
1986 De Lange T. The molecular biology of antigenic variation in trypanosomes: gene rearrangements and discontinuous transcription International Review of Cytology. 99: 85-117. PMID 3007387  1
1985 De Lange T, Kooter JM, Luirink J, Borst P. Transcription of a transposed trypanosome surface antigen gene starts upstream of the transposed segment. The Embo Journal. 4: 3299-306. PMID 3004950  1
1984 Bernards A, De Lange T, Michels PA, Liu AY, Huisman MJ, Borst P. Two modes of activation of a single surface antigen gene of Trypanosoma brucei. Cell. 36: 163-70. PMID 6692467  1
1984 De Lange T, Michels PA, Veerman HJ, Cornelissen AW, Borst P. Many trypanosome messenger RNAs share a common 5' terminal sequence. Nucleic Acids Research. 12: 3777-90. PMID 6547230  1
1984 De Lange T, Berkvens TM, Veerman HJ, Frasch AC, Barry JD, Borst P. Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species. Nucleic Acids Research. 12: 4431-43. PMID 6204273 DOI: 10.1093/nar/12.11.4431  1
1984 Kooter JM, De Lange T, Borst P. Discontinuous synthesis of mRNA in trypanosomes. The Embo Journal. 3: 2387-92. PMID 6094183  1
1984 de Lange T, Michels PAM, Veerman HJG, Cornelissen AWCa, Borst P. Many trypanosome messenger RNAs share a common 5′ terminal sequence Nucleic Acids Research. 12: 3777-3790. DOI: 10.1093/nar/12.9.3777  1
1983 De Lange T, Kooter JM, Michels PA, Borst P. Telomere conversion in trypanosomes. Nucleic Acids Research. 11: 8149-65. PMID 6324075 DOI: 10.1093/nar/11.23.8149  1
1983 Borst P, Bernards A, van der Ploeg LH, Michels PA, Liu AY, de Lange T, Kooter JM. The control of variant surface antigen synthesis in trypanosomes. European Journal of Biochemistry / Febs. 137: 383-9. PMID 6319121  1
1983 De Lange T, Liu AY, Van der Ploeg LH, Borst P, Tromp MC, Van Boom JH. Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription? Cell. 34: 891-900. PMID 6313212 DOI: 10.1016/0092-8674(83)90546-9  1
1982 De Lange T, Borst P. Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature. 299: 451-3. PMID 7121582  1
1982 Van der Ploeg LH, Valerio D, De Lange T, Bernards A, Borst P, Grosveld FG. An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome. Nucleic Acids Research. 10: 5905-23. PMID 6292859 DOI: 10.1093/nar/10.19.5905  1
1982 Van der Ploeg LH, Liu AY, Michels PA, De Lange T, Borst P, Majumder HK, Weber H, Veeneman GH, Van Boom J. RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. Nucleic Acids Research. 10: 3591-604. PMID 6287414 DOI: 10.1093/nar/10.12.3591  1
1979 Hueting S, de Lange T, Tempest DW. Energy requirement for maintenance of the transmembrane potassium gradient in Klebsiella aerogenes NCTC 418: a continuous culture study. Archives of Microbiology. 123: 183-8. PMID 395915 DOI: 10.1007/BF00446818  1
1978 Hueting S, de Lange T, Tempest DW. Properties and regulation of synthesis of the glycerol dehydrogenase present in Klebsiella aerogenes NCTC 418, growing in chemostat culture Fems Microbiology Letters. 4: 185-189.  1
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