| Year |
Citation |
Score |
| 2024 |
Takai H, Aria V, Borges P, Yeeles JTP, de Lange T. CST-polymerase α-primase solves a second telomere end-replication problem. Nature. PMID 38418884 DOI: 10.1038/s41586-024-07137-1 |
0.382 |
|
| 2024 |
Sonmez C, Toia B, Eickhoff P, Matei AM, El Beyrouthy M, Wallner B, Douglas ME, de Lange T, Lottersberger F. DNA-PK controls Apollo's access to leading-end telomeres. Nucleic Acids Research. PMID 38407308 DOI: 10.1093/nar/gkae105 |
0.354 |
|
| 2024 |
Kinzig CG, Zakusilo G, Takai KK, Myler LR, de Lange T. ATR blocks telomerase from converting DNA breaks into telomeres. Science (New York, N.Y.). 383: 763-770. PMID 38359122 DOI: 10.1126/science.adg3224 |
0.475 |
|
| 2023 |
Takai H, Aria V, Borges P, Yeeles JTP, de Lange T. CST-Polymeraseα-primase solves a second telomere end-replication problem. Biorxiv : the Preprint Server For Biology. PMID 37961611 DOI: 10.1101/2023.10.26.564248 |
0.367 |
|
| 2023 |
Myler LR, Toia B, Vaughan CK, Takai K, Matei AM, Wu P, Paull TT, de Lange T, Lottersberger F. DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres. Nature Structural & Molecular Biology. PMID 37653239 DOI: 10.1038/s41594-023-01072-x |
0.452 |
|
| 2023 |
Cai SW, de Lange T. CST-Polα/Primase: the second telomere maintenance machine. Genes & Development. 37: 555-569. PMID 37495394 DOI: 10.1101/gad.350479.123 |
0.47 |
|
| 2023 |
Cai SW, Takai H, Walz T, de Lange T. Structural basis of CST-Polα/Primase recruitment and regulation by POT1 at telomeres. Biorxiv : the Preprint Server For Biology. PMID 37215005 DOI: 10.1101/2023.05.08.539880 |
0.313 |
|
| 2022 |
Yang Z, Sharma K, de Lange T. TRF1 uses a noncanonical function of TFIIH to promote telomere replication. Genes & Development. PMID 36229075 DOI: 10.1101/gad.349975.122 |
0.408 |
|
| 2022 |
Mirman Z, Cai S, de Lange T. CST/Polα/primase-mediated fill-in synthesis at DSBs. Cell Cycle (Georgetown, Tex.). 1-11. PMID 36205622 DOI: 10.1080/15384101.2022.2123886 |
0.323 |
|
| 2022 |
Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T. Shelterin is a dimeric complex with extensive structural heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201662119. PMID 35881804 DOI: 10.1073/pnas.2201662119 |
0.308 |
|
| 2022 |
Mirman Z, Sharma K, Carroll TS, de Lange T. Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4. Dna Repair. 113: 103320. PMID 35316728 DOI: 10.1016/j.dnarep.2022.103320 |
0.34 |
|
| 2022 |
Mirman Z, Sasi NK, King A, Chapman JR, de Lange T. 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis. Nature Cell Biology. 24: 51-61. PMID 35027730 DOI: 10.1038/s41556-021-00812-9 |
0.402 |
|
| 2021 |
Myler LR, Kinzig CG, Sasi NK, Zakusilo G, Cai SW, de Lange T. The evolution of metazoan shelterin. Genes & Development. 35: 1625-1641. PMID 34764137 DOI: 10.1101/gad.348835.121 |
0.42 |
|
| 2021 |
Lazzerini Denchi E, Celli G, de Lange T. Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes & Development. 35: 1548-1549. PMID 34725130 DOI: 10.1101/gad.349030.121 |
0.729 |
|
| 2021 |
Dewhurst SM, Yao X, Rosiene J, Tian H, Behr J, Bosco N, Takai KK, de Lange T, Imieliński M. Structural variant evolution after telomere crisis. Nature Communications. 12: 2093. PMID 33828097 DOI: 10.1038/s41467-021-21933-7 |
0.379 |
|
| 2020 |
Schmutz I, Mensenkamp AR, Takai KK, Haadsma M, Spruijt L, de Voer RM, Choo SS, Lorbeer FK, van Grinsven EJ, Hockemeyer D, Jongmans MC, de Lange T. is a haploinsufficient tumor suppressor that limits telomere length. Elife. 9. PMID 33258446 DOI: 10.7554/eLife.61235 |
0.683 |
|
| 2020 |
Yang Z, Takai KK, Lovejoy CA, de Lange T. Break-induced replication promotes fragile telomere formation. Genes & Development. PMID 32883681 DOI: 10.1101/Gad.328575.119 |
0.488 |
|
| 2020 |
Maciejowski J, Chatzipli A, Dananberg A, Chu K, Toufektchan E, Klimczak LJ, Gordenin DA, Campbell PJ, de Lange T. APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis. Nature Genetics. PMID 32719516 DOI: 10.1038/s41588-020-0667-5 |
0.375 |
|
| 2020 |
Timashev LA, de Lange T. Characterization of t-loop formation by TRF2. Nucleus (Austin, Tex.). PMID 32564646 DOI: 10.1080/19491034.2020.1783782 |
0.309 |
|
| 2020 |
Mirman Z, de Lange T. 53BP1: a DSB escort. Genes & Development. 34: 7-23. PMID 31896689 DOI: 10.1101/gad.333237.119 |
0.333 |
|
| 2020 |
Lovejoy CA, Takai K, Huh MS, Picketts DJ, de Lange T. ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity. Plos Biology. 18: e3000594. PMID 31895940 DOI: 10.1371/Journal.Pbio.3000594 |
0.447 |
|
| 2018 |
de Lange T. Shelterin-Mediated Telomere Protection. Annual Review of Genetics. PMID 30208292 DOI: 10.1146/annurev-genet-032918-021921 |
0.445 |
|
| 2018 |
Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. PMID 30022158 DOI: 10.1038/S41586-018-0324-7 |
0.352 |
|
| 2018 |
de Lange T. What I got wrong about shelterin. The Journal of Biological Chemistry. PMID 29794139 DOI: 10.1074/jbc.AW118.003234 |
0.384 |
|
| 2017 |
Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere Protection by TPP1/POT1 Requires Tethering to TIN2. Molecular Cell. 67: 162. PMID 28686874 DOI: 10.1016/j.molcel.2017.05.033 |
0.319 |
|
| 2017 |
Timashev LA, Babcock H, Zhuang X, de Lange T. The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction. Genes & Development. PMID 28381412 DOI: 10.1101/Gad.294108.116 |
0.478 |
|
| 2017 |
Gong Y, Handa N, Kowalczykowski SC, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes & Development. PMID 28115467 DOI: 10.1101/Gad.291807.116 |
0.351 |
|
| 2017 |
Maciejowski J, de Lange T. Telomeres in cancer: tumour suppression and genome instability. Nature Reviews. Molecular Cell Biology. PMID 28096526 DOI: 10.1038/nrm.2016.171 |
0.336 |
|
| 2017 |
Erdel F, Kratz K, Willcox S, Griffith JD, Greene EC, de Lange T. Telomere Recognition and Assembly Mechanism of Mammalian Shelterin. Cell Reports. 18: 41-53. PMID 28052260 DOI: 10.1016/J.Celrep.2016.12.005 |
0.352 |
|
| 2016 |
Doksani Y, de Lange T. Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. Cell Reports. 17: 1646-1656. PMID 27806302 DOI: 10.1016/j.celrep.2016.10.008 |
0.451 |
|
| 2016 |
Schmutz I, de Lange T. Shelterin. Current Biology : Cb. 26: R397-9. PMID 27218840 DOI: 10.1016/j.cub.2016.01.056 |
0.421 |
|
| 2016 |
Takai H, Jenkinson E, Kabir S, Babul-Hirji R, Najm-Tehrani N, Chitayat DA, Crow YJ, de Lange T. A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes & Development. PMID 27013236 DOI: 10.1101/gad.276873.115 |
0.412 |
|
| 2015 |
Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T. Chromothripsis and Kataegis Induced by Telomere Crisis. Cell. 163: 1641-54. PMID 26687355 DOI: 10.1016/j.cell.2015.11.054 |
0.483 |
|
| 2015 |
Tong AS, Stern JL, Sfeir A, Kartawinata M, de Lange T, Zhu XD, Bryan TM. ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Reports. PMID 26586433 DOI: 10.1016/J.Celrep.2015.10.041 |
0.636 |
|
| 2015 |
Lottersberger F, Karssemeijer RA, Dimitrova N, de Lange T. 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. Cell. 163: 880-93. PMID 26544937 DOI: 10.1016/j.cell.2015.09.057 |
0.36 |
|
| 2014 |
Kabir S, Hockemeyer D, de Lange T. TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Reports. 9: 1273-80. PMID 25453752 DOI: 10.1016/J.Celrep.2014.10.014 |
0.739 |
|
| 2014 |
Zimmermann M, Kibe T, Kabir S, de Lange T. TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes & Development. 28: 2477-91. PMID 25344324 DOI: 10.1101/gad.251611.114 |
0.458 |
|
| 2014 |
Doksani Y, de Lange T. The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harbor Perspectives in Biology. 6: a016576. PMID 25228584 DOI: 10.1101/cshperspect.a016576 |
0.478 |
|
| 2014 |
Frescas D, de Lange T. Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection. The Journal of Biological Chemistry. 289: 24180-7. PMID 25056954 DOI: 10.1074/Jbc.M114.592592 |
0.39 |
|
| 2014 |
Frescas D, de Lange T. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1. Molecular and Cellular Biology. 34: 1349-62. PMID 24469404 DOI: 10.1128/Mcb.01052-13 |
0.404 |
|
| 2014 |
Zimmermann M, de Lange T. 53BP1: pro choice in DNA repair. Trends in Cell Biology. 24: 108-17. PMID 24094932 DOI: 10.1016/j.tcb.2013.09.003 |
0.342 |
|
| 2013 |
Doksani Y, Wu JY, de Lange T, Zhuang X. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. Cell. 155: 345-56. PMID 24120135 DOI: 10.1016/J.Cell.2013.09.048 |
0.339 |
|
| 2013 |
Lottersberger F, Bothmer A, Robbiani DF, Nussenzweig MC, de Lange T. Role of 53BP1 oligomerization in regulating double-strand break repair. Proceedings of the National Academy of Sciences of the United States of America. 110: 2146-51. PMID 23345425 DOI: 10.1073/Pnas.1222617110 |
0.392 |
|
| 2013 |
Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T. 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science (New York, N.Y.). 339: 700-4. PMID 23306437 DOI: 10.1126/science.1231573 |
0.355 |
|
| 2012 |
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. Plos Genetics. 8: e1002772. PMID 22829774 DOI: 10.1371/Journal.Pgen.1002772 |
0.779 |
|
| 2012 |
Bosco N, de Lange T. A TRF1-controlled common fragile site containing interstitial telomeric sequences. Chromosoma. 121: 465-74. PMID 22790221 DOI: 10.1007/s00412-012-0377-6 |
0.444 |
|
| 2012 |
Wu P, Takai H, de Lange T. Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Cell. 150: 39-52. PMID 22748632 DOI: 10.1016/j.cell.2012.05.026 |
0.478 |
|
| 2012 |
Davoli T, de Lange T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell. 21: 765-76. PMID 22698402 DOI: 10.1016/j.ccr.2012.03.044 |
0.417 |
|
| 2012 |
Sfeir A, de Lange T. Removal of shelterin reveals the telomere end-protection problem. Science (New York, N.Y.). 336: 593-7. PMID 22556254 DOI: 10.1126/science.1218498 |
0.386 |
|
| 2011 |
Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere protection by TPP1/POT1 requires tethering to TIN2. Molecular Cell. 44: 647-59. PMID 22099311 DOI: 10.1016/J.Molcel.2011.08.043 |
0.449 |
|
| 2011 |
Scherthan H, Sfeir A, de Lange T. Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma. 120: 151-7. PMID 20927532 DOI: 10.1007/s00412-010-0295-4 |
0.431 |
|
| 2010 |
de Lange T. How shelterin solves the telomere end-protection problem. Cold Spring Harbor Symposia On Quantitative Biology. 75: 167-77. PMID 21209389 DOI: 10.1101/sqb.2010.75.017 |
0.438 |
|
| 2010 |
Kabir S, Sfeir A, de Lange T. Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle (Georgetown, Tex.). 9: 4061-7. PMID 20948311 DOI: 10.4161/cc.9.20.13579 |
0.369 |
|
| 2010 |
de Lange T. Telomere biology and DNA repair: enemies with benefits. Febs Letters. 584: 3673-4. PMID 20655310 DOI: 10.1016/j.febslet.2010.07.030 |
0.35 |
|
| 2010 |
Wu P, van Overbeek M, Rooney S, de Lange T. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Molecular Cell. 39: 606-17. PMID 20619712 DOI: 10.1016/j.molcel.2010.06.031 |
0.502 |
|
| 2010 |
Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell. 141: 81-93. PMID 20371347 DOI: 10.1016/j.cell.2010.01.031 |
0.39 |
|
| 2010 |
Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T. Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science (New York, N.Y.). 327: 1657-61. PMID 20339076 DOI: 10.1126/science.1185100 |
0.479 |
|
| 2010 |
Kibe T, Osawa GA, Keegan CE, de Lange T. Telomere protection by TPP1 is mediated by POT1a and POT1b. Molecular and Cellular Biology. 30: 1059-66. PMID 19995905 DOI: 10.1128/MCB.01498-09 |
0.515 |
|
| 2010 |
Takai KK, Hooper S, Blackwood S, Gandhi R, de Lange T. In vivo stoichiometry of shelterin components. The Journal of Biological Chemistry. 285: 1457-67. PMID 19864690 DOI: 10.1074/jbc.M109.038026 |
0.519 |
|
| 2009 |
de Lange T. How telomeres solve the end-protection problem. Science (New York, N.Y.). 326: 948-52. PMID 19965504 DOI: 10.1126/science.1170633 |
0.474 |
|
| 2009 |
Buonomo SB, Wu Y, Ferguson D, de Lange T. Mammalian Rif1 contributes to replication stress survival and homology-directed repair. The Journal of Cell Biology. 187: 385-98. PMID 19948482 DOI: 10.1083/jcb.200902039 |
0.358 |
|
| 2009 |
Dimitrova N, de Lange T. Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Molecular and Cellular Biology. 29: 5552-63. PMID 19667071 DOI: 10.1128/MCB.00476-09 |
0.428 |
|
| 2009 |
Wu P, de Lange T. Human telomerase caught in the act. Cell. 138: 432-4. PMID 19665967 DOI: 10.1016/j.cell.2009.07.018 |
0.339 |
|
| 2009 |
Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103. PMID 19596237 DOI: 10.1016/J.Cell.2009.06.021 |
0.811 |
|
| 2009 |
Palm W, Hockemeyer D, Kibe T, de Lange T. Functional dissection of human and mouse POT1 proteins. Molecular and Cellular Biology. 29: 471-82. PMID 18955498 DOI: 10.1128/Mcb.01352-08 |
0.727 |
|
| 2008 |
Dimitrova N, Chen YC, Spector DL, de Lange T. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 456: 524-8. PMID 18931659 DOI: 10.1038/Nature07433 |
0.421 |
|
| 2008 |
Palm W, de Lange T. How shelterin protects mammalian telomeres. Annual Review of Genetics. 42: 301-34. PMID 18680434 DOI: 10.1146/Annurev.Genet.41.110306.130350 |
0.467 |
|
| 2008 |
Wu P, de Lange T. No overt nucleosome eviction at deprotected telomeres. Molecular and Cellular Biology. 28: 5724-35. PMID 18625717 DOI: 10.1128/MCB.01764-07 |
0.377 |
|
| 2008 |
Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. Engineered telomere degradation models dyskeratosis congenita. Genes & Development. 22: 1773-85. PMID 18550783 DOI: 10.1101/Gad.1679208 |
0.64 |
|
| 2008 |
Konishi A, de Lange T. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes & Development. 22: 1221-30. PMID 18451109 DOI: 10.1101/gad.1634008 |
0.436 |
|
| 2007 |
Takai H, Wang RC, Takai KK, Yang H, de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell. 131: 1248-59. PMID 18160036 DOI: 10.1016/j.cell.2007.10.052 |
0.319 |
|
| 2007 |
Denchi EL, de Lange T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature. 448: 1068-71. PMID 17687332 DOI: 10.1038/nature06065 |
0.442 |
|
| 2007 |
Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural & Molecular Biology. 14: 754-61. PMID 17632522 DOI: 10.1038/Nsmb1270 |
0.753 |
|
| 2007 |
Donigian JR, de Lange T. The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex. The Journal of Biological Chemistry. 282: 22662-7. PMID 17561506 DOI: 10.1074/jbc.M702620200 |
0.432 |
|
| 2006 |
Dimitrova N, de Lange T. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes & Development. 20: 3238-43. PMID 17158742 DOI: 10.1101/gad.1496606 |
0.43 |
|
| 2006 |
Lazzerini Denchi E, Celli G, de Lange T. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes & Development. 20: 2648-53. PMID 17015429 DOI: 10.1101/gad.1453606 |
0.79 |
|
| 2006 |
Celli GB, Denchi EL, de Lange T. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nature Cell Biology. 8: 885-90. PMID 16845382 DOI: 10.1038/ncb1444 |
0.545 |
|
| 2006 |
Hockemeyer D, Daniels JP, Takai H, de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 126: 63-77. PMID 16839877 DOI: 10.1016/J.Cell.2006.04.044 |
0.769 |
|
| 2006 |
van Overbeek M, de Lange T. Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Current Biology : Cb. 16: 1295-302. PMID 16730176 DOI: 10.1016/j.cub.2006.05.022 |
0.513 |
|
| 2005 |
Jacobs JJ, de Lange T. p16INK4a as a second effector of the telomere damage pathway. Cell Cycle (Georgetown, Tex.). 4: 1364-8. PMID 16177573 |
0.404 |
|
| 2005 |
de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes & Development. 19: 2100-10. PMID 16166375 DOI: 10.1101/gad.1346005 |
0.494 |
|
| 2005 |
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/Sj.Emboj.7600733 |
0.772 |
|
| 2005 |
Celli GB, de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nature Cell Biology. 7: 712-8. PMID 15968270 DOI: 10.1038/ncb1275 |
0.476 |
|
| 2004 |
Wang RC, Smogorzewska A, de Lange T. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell. 119: 355-68. PMID 15507207 DOI: 10.1016/J.Cell.2004.10.011 |
0.708 |
|
| 2004 |
Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes & Development. 18: 2108-19. PMID 15342490 DOI: 10.1101/Gad.1216004 |
0.436 |
|
| 2004 |
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. The Journal of Biological Chemistry. 279: 47264-71. PMID 15316005 DOI: 10.1074/Jbc.M409047200 |
0.453 |
|
| 2004 |
Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. Plos Biology. 2: E240. PMID 15314656 DOI: 10.1371/Journal.Pbio.0020240 |
0.725 |
|
| 2004 |
Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes & Development. 18: 1649-54. PMID 15231715 DOI: 10.1101/Gad.1215404 |
0.716 |
|
| 2004 |
Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins. Annual Review of Biochemistry. 73: 177-208. PMID 15189140 DOI: 10.1146/Annurev.Biochem.73.071403.160049 |
0.731 |
|
| 2004 |
Ye JZ, de Lange T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nature Genetics. 36: 618-23. PMID 15133513 DOI: 10.1038/ng1360 |
0.407 |
|
| 2004 |
Loayza D, de Lange T. Telomerase regulation at the telomere: a binary switch. Cell. 117: 279-80. PMID 15109487 DOI: 10.1016/S0092-8674(04)00409-X |
0.367 |
|
| 2004 |
Loayza D, Parsons H, Donigian J, Hoke K, de Lange T. DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. The Journal of Biological Chemistry. 279: 13241-8. PMID 14715659 DOI: 10.1074/jbc.M312309200 |
0.313 |
|
| 2003 |
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JH, de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Molecular Cell. 12: 1489-98. PMID 14690602 DOI: 10.1016/S1097-2765(03)00478-7 |
0.776 |
|
| 2003 |
Li B, de Lange T. Rap1 affects the length and heterogeneity of human telomeres. Molecular Biology of the Cell. 14: 5060-8. PMID 14565979 DOI: 10.1091/Mbc.E03-06-0403 |
0.435 |
|
| 2003 |
Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Current Biology : Cb. 13: 1549-56. PMID 12956959 DOI: 10.1016/S0960-9822(03)00542-6 |
0.696 |
|
| 2003 |
Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Molecular and Cellular Biology. 23: 6533-41. PMID 12944479 DOI: 10.1128/Mcb.23.18.6533-6541.2003 |
0.792 |
|
| 2003 |
Loayza D, De Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature. 423: 1013-8. PMID 12768206 DOI: 10.1038/nature01688 |
0.497 |
|
| 2002 |
Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Current Biology : Cb. 12: 1635-44. PMID 12361565 DOI: 10.1016/S0960-9822(02)01179-X |
0.818 |
|
| 2002 |
Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. The Embo Journal. 21: 4338-48. PMID 12169636 DOI: 10.1093/Emboj/Cdf433 |
0.689 |
|
| 2002 |
Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science (New York, N.Y.). 295: 2446-9. PMID 11923537 DOI: 10.1126/Science.1069523 |
0.808 |
|
| 2002 |
de Lange T. Protection of mammalian telomeres. Oncogene. 21: 532-40. PMID 11850778 DOI: 10.1038/sj.onc.1205080 |
0.505 |
|
| 2001 |
Stansel RM, de Lange T, Griffith JD. T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang. The Embo Journal. 20: 5532-40. PMID 11574485 DOI: 10.1093/Emboj/20.19.5532 |
0.371 |
|
| 2001 |
Fairall L, Chapman L, Moss H, de Lange T, Rhodes D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Molecular Cell. 8: 351-61. PMID 11545737 DOI: 10.1016/S1097-2765(01)00321-5 |
0.328 |
|
| 2001 |
De Lange T. Telomere capping - One strand fits all Science. 292: 1075-1076. PMID 11352055 DOI: 10.1126/science.1061032 |
0.359 |
|
| 2000 |
Scherthan H, Jerratsch M, Li B, Smith S, Hultén M, Lock T, de Lange T. Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Molecular Biology of the Cell. 11: 4189-203. PMID 11102517 DOI: 10.1091/Mbc.11.12.4189 |
0.576 |
|
| 2000 |
Smith S, de Lange T. Tankyrase promotes telomere elongation in human cells. Current Biology : Cb. 10: 1299-302. PMID 11069113 DOI: 10.1016/S0960-9822(00)00752-1 |
0.602 |
|
| 2000 |
Zhu XD, Küster B, Mann M, Petrini JH, de Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nature Genetics. 25: 347-52. PMID 10888888 DOI: 10.1038/77139 |
0.643 |
|
| 2000 |
Smogorzewska A, Van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, De Lange T. Control of human telomere length by TRF1 and TRF2 Molecular and Cellular Biology. 20: 1659-1668. PMID 10669743 DOI: 10.1128/Mcb.20.5.1659-1668.2000 |
0.74 |
|
| 2000 |
Li B, Oestreich S, De Lange T. Identification of human rap1: Implications for telomere evolution Chemtracts. 13: 877-882. |
0.302 |
|
| 1999 |
Smith S, de Lange T. Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes. Journal of Cell Science. 112: 3649-56. PMID 10523501 |
0.395 |
|
| 1999 |
Bianchi A, Stansel RM, Fairall L, Griffith JD, Rhodes D, De Lange T. TRF1 binds a bipartite telomeric site with extreme spatial flexibility Embo Journal. 18: 5735-5744. PMID 10523316 DOI: 10.1093/Emboj/18.20.5735 |
0.318 |
|
| 1999 |
De Lange T, Jacks T. For better or worse? Telomerase inhibition and cancer Cell. 98: 273-275. PMID 10458601 DOI: 10.1016/S0092-8674(00)81955-8 |
0.507 |
|
| 1999 |
Bianchi A, De Lange T. Ku binds telomeric DNA in vitro Journal of Biological Chemistry. 274: 21223-21227. PMID 10409678 DOI: 10.1074/jbc.274.30.21223 |
0.417 |
|
| 1999 |
Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 97: 503-14. PMID 10338214 DOI: 10.1016/S0092-8674(00)80760-6 |
0.465 |
|
| 1999 |
Zhu L, Smith S, de Lange T, Seldin MF. Chromosomal mapping of the tankyrase gene in human and mouse. Genomics. 57: 320-1. PMID 10198177 DOI: 10.1006/Geno.1999.5771 |
0.442 |
|
| 1999 |
Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science (New York, N.Y.). 283: 1321-5. PMID 10037601 DOI: 10.1126/Science.283.5406.1321 |
0.8 |
|
| 1998 |
Smith S, Giriat I, Schmitt A, de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science (New York, N.Y.). 282: 1484-7. PMID 9822378 DOI: 10.1126/Science.282.5393.1484 |
0.569 |
|
| 1998 |
Griffith J, Bianchi A, De Lange T. TRF1 promotes parallel pairing of telomeric tracts in vitro Journal of Molecular Biology. 278: 79-88. PMID 9571035 DOI: 10.1006/Jmbi.1998.1686 |
0.437 |
|
| 1998 |
Van Steensel B, Smogorzewska A, De Lange T. TRF2 protects human telomeres from end-to-end fusions Cell. 92: 401-413. PMID 9476899 DOI: 10.1016/S0092-8674(00)80932-0 |
0.75 |
|
| 1998 |
De Lange T. Telomeres and senescence: Ending the debate Science. 279: 334-335. PMID 9454329 DOI: 10.1126/science.279.5349.334 |
0.381 |
|
| 1997 |
Broccoli D, Smogorzewska A, Chong L, de Lange T. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics. 17: 231-5. PMID 9326950 DOI: 10.1038/ng1097-231 |
0.812 |
|
| 1997 |
Bianchi A, Smith S, Chong L, Elias P, de Lange T. TRF1 is a dimer and bends telomeric DNA. The Embo Journal. 16: 1785-94. PMID 9130722 DOI: 10.1093/Emboj/16.7.1785 |
0.547 |
|
| 1997 |
Van Steensel B, De Lange T. Control of telomere length by the human telomeric protein TRF1 Nature. 385: 740-743. PMID 9034193 DOI: 10.1038/385740a0 |
0.505 |
|
| 1997 |
Smith S, de Lange T. TRF1, a mammalian telomeric protein. Trends in Genetics : Tig. 13: 21-6. PMID 9009844 DOI: 10.1016/S0168-9525(96)10052-4 |
0.618 |
|
| 1997 |
Broccoli D, Chong L, Oelmann S, Fernald AA, Marziliano N, van Steensel B, Kipling D, Le Beau MM, de Lange T. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Human Molecular Genetics. 6: 69-76. PMID 9002672 DOI: 10.1093/Hmg/6.1.69 |
0.724 |
|
| 1996 |
Ludérus MEE, Van Steensel B, Chong L, Sibon OCM, Cremers FFM, De Lange T. Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex Journal of Cell Biology. 135: 867-881. PMID 8922373 |
0.353 |
|
| 1996 |
Broccoli D, Godley LA, Donehower LA, Varmus HE, de Lange T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Molecular and Cellular Biology. 16: 3765-72. PMID 8668193 DOI: 10.1128/Mcb.16.7.3765 |
0.72 |
|
| 1995 |
Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 9082-6. PMID 7568077 DOI: 10.1073/Pnas.92.20.9082 |
0.645 |
|
| 1995 |
Chong L, van Steensel B, Broccoli D, Erdjument-Bromage H, Hanish J, Tempst P, de Lange T. A human telomeric protein. Science (New York, N.Y.). 270: 1663-7. PMID 7502076 DOI: 10.1126/Science.270.5242.1663 |
0.78 |
|
| 1994 |
Hanish JP, Yanowitz JL, De Lange T. Stringent sequence requirements for the formation of human telomeres Proceedings of the National Academy of Sciences of the United States of America. 91: 8861-8865. PMID 8090736 DOI: 10.1073/pnas.91.19.8861 |
0.471 |
|
| 1994 |
Tommerup H, Dousmanis A, De Lange T. Unusual chromatin in human telomeres Molecular and Cellular Biology. 14: 5777-5785. PMID 8065312 |
0.343 |
|
| 1993 |
Saltman D, Morgan R, Cleary ML, de Lange T. Telomeric structure in cells with chromosome end associations Chromosoma. 102: 121-128. PMID 8432193 DOI: 10.1007/BF00356029 |
0.419 |
|
| 1993 |
Cardenas ME, Bianchi A, De Lange T. A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins Genes and Development. 7: 883-894. PMID 7684008 |
0.378 |
|
| 1992 |
De Lange T. Human telomeres are attached to the nuclear matrix Embo Journal. 11: 717-724. PMID 1537344 |
0.346 |
|
| 1992 |
Zhong Z, Shiue L, Kaplan S, De Lange T. A mammalian factor that binds telomeric TTAGGG repeats in vitro Molecular and Cellular Biology. 12: 4834-4843. PMID 1406665 DOI: 10.1128/MCB.12.11.4834 |
0.406 |
|
| 1990 |
de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE. Structure and variability of human chromosome ends. Molecular and Cellular Biology. 10: 518-27. PMID 2300052 DOI: 10.1128/Mcb.10.2.518 |
0.618 |
|
| 1987 |
Timmers HT, de Lange T, Kooter JM, Borst P. Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei. Journal of Molecular Biology. 194: 81-90. PMID 3612801 DOI: 10.1016/0022-2836(87)90717-0 |
0.452 |
|
| 1987 |
Stone J, de Lange T, Ramsay G, Jakobovits E, Bishop JM, Varmus H, Lee W. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Molecular and Cellular Biology. 7: 1697-709. PMID 3299053 DOI: 10.1128/mcb.7.5.1697-1709.1987 |
0.578 |
|
| 1986 |
Bernards A, Van der Ploeg LH, Gibson WC, Leegwater P, Eijgenraam F, De Lange T, Weijers P, Calafat J, Borst P. Rapid change of the repertoire of variant surface glycoprotein genes in trypanosomes by gene duplication and deletion. Journal of Molecular Biology. 190: 1-10. PMID 3783693 DOI: 10.1016/0022-2836(86)90070-7 |
0.668 |
|
| 1985 |
De Lange T, Kooter JM, Luirink J, Borst P. Transcription of a transposed trypanosome surface antigen gene starts upstream of the transposed segment. The Embo Journal. 4: 3299-306. PMID 3004950 DOI: 10.1002/J.1460-2075.1985.Tb04080.X |
0.488 |
|
| 1984 |
Bernards A, De Lange T, Michels PA, Liu AY, Huisman MJ, Borst P. Two modes of activation of a single surface antigen gene of Trypanosoma brucei. Cell. 36: 163-70. PMID 6692467 DOI: 10.1016/0092-8674(84)90085-0 |
0.682 |
|
| 1984 |
De Lange T, Michels PA, Veerman HJ, Cornelissen AW, Borst P. Many trypanosome messenger RNAs share a common 5' terminal sequence. Nucleic Acids Research. 12: 3777-90. PMID 6547230 DOI: 10.1093/Nar/12.9.3777 |
0.436 |
|
| 1984 |
De Lange T, Berkvens TM, Veerman HJ, Frasch AC, Barry JD, Borst P. Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species. Nucleic Acids Research. 12: 4431-43. PMID 6204273 DOI: 10.1093/Nar/12.11.4431 |
0.4 |
|
| 1984 |
Kooter JM, De Lange T, Borst P. Discontinuous synthesis of mRNA in trypanosomes. The Embo Journal. 3: 2387-92. PMID 6094183 DOI: 10.1002/J.1460-2075.1984.Tb02144.X |
0.423 |
|
| 1984 |
de Lange T, Michels PAM, Veerman HJG, Cornelissen AWCa, Borst P. Many trypanosome messenger RNAs share a common 5′ terminal sequence Nucleic Acids Research. 12: 3777-3790. DOI: 10.1093/nar/12.9.3777 |
0.367 |
|
| 1983 |
De Lange T, Kooter JM, Michels PA, Borst P. Telomere conversion in trypanosomes. Nucleic Acids Research. 11: 8149-65. PMID 6324075 DOI: 10.1093/Nar/11.23.8149 |
0.544 |
|
| 1983 |
Borst P, Bernards A, van der Ploeg LH, Michels PA, Liu AY, de Lange T, Kooter JM. The control of variant surface antigen synthesis in trypanosomes. European Journal of Biochemistry / Febs. 137: 383-9. PMID 6319121 DOI: 10.1111/J.1432-1033.1983.Tb07840.X |
0.612 |
|
| 1983 |
De Lange T, Liu AY, Van der Ploeg LH, Borst P, Tromp MC, Van Boom JH. Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription? Cell. 34: 891-900. PMID 6313212 DOI: 10.1016/0092-8674(83)90546-9 |
0.447 |
|
| 1982 |
De Lange T, Borst P. Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature. 299: 451-3. PMID 7121582 DOI: 10.1038/299451A0 |
0.534 |
|
| 1982 |
Van der Ploeg LH, Valerio D, De Lange T, Bernards A, Borst P, Grosveld FG. An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome. Nucleic Acids Research. 10: 5905-23. PMID 6292859 DOI: 10.1093/Nar/10.19.5905 |
0.689 |
|
| 1982 |
Van der Ploeg LH, Liu AY, Michels PA, De Lange T, Borst P, Majumder HK, Weber H, Veeneman GH, Van Boom J. RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. Nucleic Acids Research. 10: 3591-604. PMID 6287414 DOI: 10.1093/Nar/10.12.3591 |
0.445 |
|
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