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Mark W. Ruszczycky - Publications

Affiliations: 
Biochemistry Case Western Reserve University, Cleveland Heights, OH, United States 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lee YH, Yeh YC, Fan PH, Zhong A, Ruszczycky MW, Liu HW. Changing Fates of the Substrate Radicals Generated in the Active Sites of the B-Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society. PMID 36719327 DOI: 10.1021/jacs.2c12953  0.368
2022 Zhang J, Hou X, Chen Z, Ko Y, Ruszczycky MW, Chen Y, Zhou J, Liu HW. Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. Journal of the American Chemical Society. PMID 35622017 DOI: 10.1021/jacs.2c02676  0.339
2022 Lee YH, Hou X, Chen R, Feng J, Liu X, Ruszczycky MW, Gao JM, Wang B, Zhou J, Liu HW. Radical -Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S. Journal of the American Chemical Society. PMID 35238201 DOI: 10.1021/jacs.1c12010  0.357
2021 Jeon BS, Huang TY, Ruszczycky MW, Choi SH, Kim N, Franklin JL, Hung SC, Liu HW. Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation. Tetrahedron. 103. PMID 35685987 DOI: 10.1016/j.tet.2021.132569  0.363
2021 Choi SH, Jeon B, Kim N, Wu HH, Ko TP, Ruszczycky MW, Isiorho EA, Liu YN, Keatinge-Clay AT, Tsai MD, Liu HW. Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A. Journal of the American Chemical Society. PMID 34813308 DOI: 10.1021/jacs.1c09482  0.348
2021 Besandre RA, Chen Z, Davis I, Zhang J, Ruszczycky MW, Liu A, Liu HW. HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue. Journal of the American Chemical Society. PMID 34491039 DOI: 10.1021/jacs.1c05727  0.365
2020 Ren D, Ruszczycky MW, Ko Y, Wang SA, Ogasawara Y, Kim M, Liu HW. Characterization of the coformycin biosynthetic gene cluster in . Proceedings of the National Academy of Sciences of the United States of America. PMID 32350138 DOI: 10.1073/Pnas.2000111117  0.366
2019 Ruszczycky MW, Liu HW. Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting. Biochemistry. PMID 31710808 DOI: 10.1021/Acs.Biochem.9B00762  0.394
2018 Ushimaru R, Ruszczycky MW, Liu HW. Changes in regioselectivity of H atom abstraction during the hydroxylation and cyclization reactions catalyzed by hyoscyamine 6β-hydroxylase. Journal of the American Chemical Society. PMID 30545219 DOI: 10.1021/Jacs.8B11585  0.375
2018 Ushimaru R, Ruszczycky MW, Chang WC, Yan F, Liu YN, Liu HW. Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions. Journal of the American Chemical Society. PMID 29870653 DOI: 10.1021/Jacs.8B03729  0.386
2018 Ruszczycky MW, Zhong A, Liu HW. Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes. Natural Product Reports. PMID 29485151 DOI: 10.1039/C7Np00058H  0.403
2018 Ko Y, Lin GM, Ruszczycky MW, Liu HW. Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-D-fucose Catalyzed by the Radical SAM Enzyme DesII. Biochemistry. PMID 29473739 DOI: 10.1021/Acs.Biochem.8B00110  0.458
2017 Ruszczycky MW, Liu HW. Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants. Methods in Enzymology. 596: 459-499. PMID 28911781 DOI: 10.1016/Bs.Mie.2017.07.022  0.43
2017 Jeon BS, Ruszczycky MW, Russell WK, Lin GM, Kim N, Choi SH, Wang SA, Liu YN, Patrick JW, Russell DH, Liu HW. Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874588 DOI: 10.1073/Pnas.1710496114  0.448
2017 Jeon BS, Wang SA, Ruszczycky MW, Liu HW. Natural [4 + 2]-Cyclases. Chemical Reviews. 117: 5367-5388. PMID 28441874 DOI: 10.1021/Acs.Chemrev.6B00578  0.411
2017 Ko Y, Wang SA, Ogasawara Y, Ruszczycky MW, Liu HW. Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A. Organic Letters. PMID 28233490 DOI: 10.1021/Acs.Orglett.7B00355  0.404
2015 Ruszczycky MW, Liu HW. Mechanistic Enzymology of the Radical SAM Enzyme DesII. Israel Journal of Chemistry. 55: 315-324. PMID 27635101 DOI: 10.1002/Ijch.201400130  0.441
2015 Lin GM, Choi SH, Ruszczycky MW, Liu HW. Mechanistic Investigation of the Radical S-Adenosyl-L-methionine Enzyme DesII Using Fluorinated Analogues. Journal of the American Chemical Society. 137: 4964-7. PMID 25826575 DOI: 10.1021/Jacs.5B02545  0.46
2015 Ko Y, Ruszczycky MW, Choi SH, Liu HW. Mechanistic studies of the radical S-adenosylmethionine enzyme DesII with TDP-D-fucose. Angewandte Chemie (International Ed. in English). 54: 860-3. PMID 25418063 DOI: 10.1002/Anie.201409540  0.366
2015 Ruszczycky MW, Liu HW. Mechanistic enzymology of the radical SAM enzyme DesII Israel Journal of Chemistry. 55: 315-324. DOI: 10.1002/ijch.201400130  0.355
2013 Ruszczycky MW, Choi SH, Liu HW. EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII. Proceedings of the National Academy of Sciences of the United States of America. 110: 2088-93. PMID 23329328 DOI: 10.1073/Pnas.1209446110  0.405
2012 Kim HJ, Ruszczycky MW, Liu HW. Current developments and challenges in the search for a naturally selected Diels-Alderase. Current Opinion in Chemical Biology. 16: 124-31. PMID 22260931 DOI: 10.1016/J.Cbpa.2011.12.017  0.435
2012 Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW. Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. The Journal of Biological Chemistry. 287: 4602-8. PMID 22187430 DOI: 10.1074/Jbc.M111.312538  0.357
2012 Ruszczycky MW, Ogasawara Y, Liu HW. Radical SAM enzymes in the biosynthesis of sugar-containing natural products. Biochimica Et Biophysica Acta. 1824: 1231-44. PMID 22172915 DOI: 10.1016/J.Bbapap.2011.11.006  0.45
2011 Kim HJ, Ruszczycky MW, Choi SH, Liu YN, Liu HW. Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A. Nature. 473: 109-12. PMID 21544146 DOI: 10.1038/Nature09981  0.451
2011 Ruszczycky MW, Choi SH, Mansoorabadi SO, Liu HW. Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. Journal of the American Chemical Society. 133: 7292-5. PMID 21513273 DOI: 10.1021/Ja201212F  0.405
2011 Kim HJ, Ruszczycky MW, Choi S-, Liu Y-, Liu H-. Biosynthesis of Spinosyn A Synfacts. 2011: 781-781. DOI: 10.1055/S-0030-1260636  0.323
2010 Ruszczycky MW, Choi SH, Liu HW. Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII. Journal of the American Chemical Society. 132: 2359-69. PMID 20121093 DOI: 10.1021/Ja909451A  0.404
2009 Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW. Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. Journal of the American Chemical Society. 131: 14030-42. PMID 19746907 DOI: 10.1021/Ja903354K  0.414
2009 Ruszczycky MW, Anderson VE. β-Secondary deuterium equilibrium and kinetic isotope effects on nucleophilic attack by methanol at a carbonyl: Computational estimation of deviation from the rule of the geometric mean Journal of Molecular Structure: Theochem. 895: 107-115. DOI: 10.1016/J.Theochem.2008.10.024  0.534
2008 Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, et al. Inhibition of OXA-1 beta-lactamase by penems. Antimicrobial Agents and Chemotherapy. 52: 3135-43. PMID 18559643 DOI: 10.1128/Aac.01677-07  0.527
2006 Bethel CR, Hujer AM, Hujer KM, Thomson JM, Ruszczycky MW, Anderson VE, Pusztai-Carey M, Taracila M, Helfand MS, Bonomo RA. Role of Asp104 in the SHV beta-lactamase. Antimicrobial Agents and Chemotherapy. 50: 4124-31. PMID 16982784 DOI: 10.1128/Aac.00848-06  0.513
2006 Ruszczycky MW, Anderson VE. Interpretation of V/K isotope effects for enzymatic reactions exhibiting multiple isotopically sensitive steps. Journal of Theoretical Biology. 243: 328-42. PMID 16914160 DOI: 10.1016/J.Jtbi.2006.06.022  0.548
2006 Anderson VE, Ruszczycky MW, Harris ME. Activation of oxygen nucleophiles in enzyme catalysis. Chemical Reviews. 106: 3236-51. PMID 16895326 DOI: 10.1021/Cr050281Z  0.546
2004 Ruszczycky MW, Anderson VE. Tartrate dehydrogenase reductive decarboxylation: stereochemical generation of diastereotopically deuterated hydroxymethylenes. Bioorganic Chemistry. 32: 51-61. PMID 14700562 DOI: 10.1016/J.Bioorg.2003.09.006  0.491
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