Jack W. Szostak - Publications

Affiliations: 
Genetics Harvard Medical School, Boston, MA, United States 
Area:
origin of life
Website:
https://www.nobelprize.org/prizes/medicine/2009/szostak/biographical/

279 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhou L, O'Flaherty DK, Szostak JW. Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation. Journal of the American Chemical Society. PMID 32820909 DOI: 10.1021/jacs.0c06722  0.36
2020 Zhang SJ, Duzdevich D, Szostak JW. Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying. Journal of the American Chemical Society. 142: 14810-14813. PMID 32794700 DOI: 10.1021/jacs.0c05300  0.36
2020 Kindt JT, Szostak JW, Wang A. Bulk Self-Assembly of Giant, Unilamellar Vesicles. Acs Nano. PMID 32602696 DOI: 10.1021/acsnano.0c03125  0.01
2020 Zhou L, O'Flaherty DK, Szostak JW. Template-directed copying of RNA by non-enzymatic ligation. Angewandte Chemie (International Ed. in English). PMID 32558121 DOI: 10.1002/anie.202004934  0.01
2020 Duzdevich D, Carr CE, Szostak JW. Deep sequencing of non-enzymatic RNA primer extension. Nucleic Acids Research. PMID 32427335 DOI: 10.1093/nar/gkaa400  0.01
2020 Yildirim O, Izgu EC, Damle M, Chalei V, Ji F, Sadreyev RI, Szostak JW, Kingston RE. S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. Cell Reports. 31: 107629. PMID 32402276 DOI: 10.1016/j.celrep.2020.107629  0.01
2020 Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ, Szostak JW, Sasselov DD. Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions. Astrobiology. PMID 32267736 DOI: 10.1089/ast.2019.2182  0.01
2020 Lelyveld VS, Zhang W, Szostak JW. Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32188786 DOI: 10.1073/pnas.1922400117  0.01
2020 Walton T, DasGupta S, Duzdevich D, Oh SS, Szostak JW. In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123094 DOI: 10.1073/pnas.1914367117  0.01
2020 Kim SC, Zhou L, Zhang W, O'Flaherty DK, Rondo-Brovetto V, Szostak JW. A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2'-deoxynucleotides. Journal of the American Chemical Society. PMID 31913615 DOI: 10.1021/jacs.9b11239  0.01
2019 Chizzolini F, Passalacqua LFM, Oumais M, Dingilian AI, Szostak JW, Lupták A. Large phenotypic enhancement of structured random RNA pools. Journal of the American Chemical Society. PMID 31887027 DOI: 10.1021/jacs.9b11396  0.01
2019 Zhou L, Kim S, Ho KH, O'Flaherty DK, Giurgiu C, Wright TH, Szostak JW. Non-enzymatic primer extension with strand displacement. Elife. 8. PMID 31702557 DOI: 10.7554/eLife.51888  0.01
2019 Wright TH, Giurgiu C, Zhang W, Radakovic A, O'Flaherty DK, Zhou L, Szostak JW. Prebiotically Plausible 'Patching' of RNA Backbone Cleavage Through a 3'-5' Pyrophosphate Linkage. Journal of the American Chemical Society. PMID 31651170 DOI: 10.1021/jacs.9b08237  0.01
2019 Lelyveld VS, O'Flaherty DK, Zhou L, Izgu EC, Szostak JW. DNA polymerase activity on synthetic N3'→P5' phosphoramidate DNA templates. Nucleic Acids Research. PMID 31428779 DOI: 10.1093/nar/gkz707  0.01
2019 Todd ZR, Szabla R, Szostak JW, Sasselov DD. UV photostability of three 2-aminoazoles with key roles in prebiotic chemistry on the early earth. Chemical Communications (Cambridge, England). PMID 31380533 DOI: 10.1039/c9cc05265h  0.01
2019 Zhang W, Pal A, Ricardo A, Szostak JW. Template-directed Nonenzymatic Primer Extension Using 2-methylimidazole-activated Morpholino Derivatives of Guanosine and Cytidine. Journal of the American Chemical Society. PMID 31298852 DOI: 10.1021/jacs.9b06453  0.01
2019 O'Flaherty DK, Zhou L, Szostak JW. Nonenzymatic template-directed synthesis of mixed-sequence 3'-NP-DNA up to 25 nucleotides long inside model protocells. Journal of the American Chemical Society. PMID 31180644 DOI: 10.1021/jacs.9b04858  0.01
2019 Walton T, Zhang W, Li L, Tam CP, Szostak JW. The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. Angewandte Chemie (International Ed. in English). PMID 30908802 DOI: 10.1002/anie.201902050  0.01
2019 Strom KR, Szostak JW, Prywes N. Transfer of Sequence Information and Replication of Diimine Duplexes. The Journal of Organic Chemistry. PMID 30855962 DOI: 10.1021/acs.joc.9b00095  0.01
2019 Wang A, Chan Miller C, Szostak JW. Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity. Biophysical Journal. PMID 30686489 DOI: 10.1016/j.bpj.2019.01.006  0.01
2019 Matsushita-Ishiodori Y, Hanczyc MM, Wang A, Szostak JW, Yomo T. Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 30645943 DOI: 10.1021/acs.langmuir.8b03635  0.01
2019 Szostak J. How Did Life Begin? Scientific American. 318: 65-67. PMID 29949547 DOI: 10.1038/scientificamerican0618-65  0.01
2018 Walton T, Pazienza L, Szostak JW. Template-directed catalysis of a multi-step reaction pathway for nonenzymatic RNA primer extension. Biochemistry. PMID 30566332 DOI: 10.1021/acs.biochem.8b01156  0.01
2018 Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW. Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 30509978 DOI: 10.1073/pnas.1814367115  0.01
2018 Jin L, Engelhart AE, Zhang W, Adamala KP, Szostak JW. Catalysis of Template-directed Nonenzymatic RNA Copying by Iron (II). Journal of the American Chemical Society. PMID 30335371 DOI: 10.1021/jacs.8b09617  0.01
2018 Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harbor Perspectives in Biology. 10. PMID 30181195 DOI: 10.1101/cshperspect.a034801  0.01
2018 Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI. Mettl1/Wdr4-Mediated mG tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Molecular Cell. PMID 29983320 DOI: 10.1016/j.molcel.2018.06.001  0.01
2018 Giurgiu C, Wright T, O'Flaherty D, Szostak J. A Fluorescent G-quadruplex Sensor for Chemical RNA Copying. Angewandte Chemie (International Ed. in English). PMID 29939457 DOI: 10.1002/anie.201805785  0.01
2018 Zhang W, Walton T, Li L, Szostak JW. Crystallographic observation of nonenzymatic RNA primer extension. Elife. 7. PMID 29851379 DOI: 10.7554/eLife.36422  0.01
2018 Szostak J. How Did Life Begin? Nature. 557: S13-S15. PMID 29743709 DOI: 10.1038/d41586-018-05098-w  0.01
2018 O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW. Copying of mixed sequence RNA templates inside model protocells. Journal of the American Chemical Society. PMID 29608310 DOI: 10.1021/jacs.8b00639  0.01
2018 Jin L, Engelhart AE, Adamala KP, Szostak JW. Preparation, Purification, and Use of Fatty Acid-containing Liposomes. Journal of Visualized Experiments : Jove. PMID 29553563 DOI: 10.3791/57324  0.01
2018 Jin L, Kamat NP, Jena S, Szostak JW. Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution. Small (Weinheim An Der Bergstrasse, Germany). PMID 29479815 DOI: 10.1002/smll.201704077  0.01
2018 Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW. A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide. Journal of the American Chemical Society. PMID 29411978 DOI: 10.1021/jacs.7b11750  0.01
2018 Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD. Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth. Chemical Communications (Cambridge, England). PMID 29334083 DOI: 10.1039/c7cc07748c  0.01
2017 Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension. Journal of the American Chemical Society. PMID 29251930 DOI: 10.1021/jacs.7b11623  0.01
2017 Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nature Chemistry. 9: 1286. PMID 29168488 DOI: 10.1038/nchem.2885  0.01
2017 Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS. UV-light-driven prebiotic synthesis of iron-sulfur clusters. Nature Chemistry. 9: 1229-1234. PMID 29168482 DOI: 10.1038/nchem.2817  0.01
2017 Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. Journal of the American Chemical Society. PMID 29112424 DOI: 10.1021/jacs.7b08784  0.01
2017 Walton T, Szostak JW. A kinetic model of nonenzymatic RNA polymerization by cytidine-5'-phosphoro-2-aminoimidazolide. Biochemistry. PMID 29022704 DOI: 10.1021/acs.biochem.7b00792  0.01
2017 Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. Rna Biology. 0. PMID 28945502 DOI: 10.1080/15476286.2017.1356566  0.01
2017 Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, et al. Not just Salk. Science (New York, N.Y.). 357: 1105-1106. PMID 28912235 DOI: 10.1126/science.aao6221  0.01
2017 Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 28673998 DOI: 10.1073/pnas.1704006114  0.01
2017 Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. Journal of the American Chemical Society. PMID 28640999 DOI: 10.1021/jacs.7b01562  0.01
2017 Stairs S, Nikmal A, Bučar DK, Zheng SL, Szostak JW, Powner MW. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides. Nature Communications. 8: 15270. PMID 28524845 DOI: 10.1038/ncomms15270  0.01
2017 Szostak JW. The Narrow Road to the Deep Past. Angewandte Chemie (International Ed. in English). PMID 28514493 DOI: 10.1002/anie.201704048  0.01
2017 Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. Journal of the American Chemical Society. PMID 28117989 DOI: 10.1021/jacs.6b13148  0.01
2017 Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. Journal of the American Chemical Society. PMID 28055190 DOI: 10.1021/jacs.6b09760  0.01
2016 Zhang W, Tam CP, Wang J, Szostak JW. Unusual Base-Pairing Interactions in Monomer-Template Complexes. Acs Central Science. 2: 916-926. PMID 28058281 DOI: 10.1021/acscentsci.6b00278  0.01
2016 Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW. N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes. Journal of the American Chemical Society. PMID 27959544 DOI: 10.1021/jacs.6b08801  0.32
2016 Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW. Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension. Chemical Communications (Cambridge, England). 52: 11905-11907. PMID 27722518 DOI: 10.1039/c6cc06925h  0.16
2016 Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW. Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication. Nature Chemistry. 8: 915-21. PMID 27657866 DOI: 10.1038/nchem.2551  0.72
2016 Szostak JW. On the origin of life. Medicina. 76: 199-203. PMID 27576276  1
2016 Walton T, Szostak JW. A highly reactive imidazolium-bridged dinucleotide intermediate in nonenzymatic RNA primer extension. Journal of the American Chemical Society. PMID 27552367 DOI: 10.1021/jacs.6b07977  0.4
2016 Prywes N, Blain JC, Del Frate F, Szostak JW. Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. Elife. 5. PMID 27351102 DOI: 10.7554/eLife.17756  0.52
2016 Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW. Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying. Chemical Communications (Cambridge, England). PMID 27109314 DOI: 10.1039/c6cc02692c  0.32
2016 Engelhart AE, Adamala KP, Szostak JW. A simple physical mechanism enables homeostasis in primitive cells. Nature Chemistry. 8: 448-53. PMID 27102678 DOI: 10.1038/nchem.2475  0.92
2016 Adamala KP, Engelhart AE, Szostak JW. Collaboration between primitive cell membranes and soluble catalysts. Nature Communications. 7: 11041. PMID 26996603 DOI: 10.1038/ncomms11041  0.96
2016 Li L, Lelyveld VS, Prywes N, Szostak JW. Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis. Journal of the American Chemical Society. PMID 26974265 DOI: 10.1021/jacs.6b00784  0.36
2016 Izgu EC, Oh SS, Szostak JW. Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates. Chemical Communications (Cambridge, England). PMID 26857159 DOI: 10.1039/c5cc10317g  0.56
2015 Lelyveld VS, Bjorkbom A, Ransey E, Sliz P, Szostak JW. Pinpointing RNA-protein crosslinks with site-specific stable isotope labeled oligonucleotides. Journal of the American Chemical Society. PMID 26583201 DOI: 10.1021/jacs.5b10596  0.28
2015 Björkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW. Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms. Journal of the American Chemical Society. PMID 26495937 DOI: 10.1021/jacs.5b09438  0.6
2015 Larsen AT, Fahrenbach AC, Sheng J, Pian J, Szostak JW. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Research. 43: 7675-87. PMID 26240387 DOI: 10.1093/nar/gkv761  0.56
2015 Kamat NP, Tobé S, Hill IT, Szostak JW. Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides. Angewandte Chemie (International Ed. in English). 54: 11735-9. PMID 26223820 DOI: 10.1002/anie.201505742  0.28
2015 Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW. Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations. Nature Protocols. 10: 927-38. PMID 26020615 DOI: 10.1038/nprot.2015.054  0.52
2015 Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC, Szostak JW. Uncovering the thermodynamics of monomer binding for RNA replication. Journal of the American Chemical Society. 137: 6373-82. PMID 25901790 DOI: 10.1021/jacs.5b02707  0.28
2015 Heuberger BD, Pal A, Del Frate F, Topkar VV, Szostak JW. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. Journal of the American Chemical Society. 137: 2769-75. PMID 25654265 DOI: 10.1021/jacs.5b00445  0.2
2015 Adamala K, Engelhart AE, Szostak JW. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension. Journal of the American Chemical Society. 137: 483-9. PMID 25521912 DOI: 10.1021/ja511564d  0.84
2014 Hentrich C, Szostak JW. Controlled growth of filamentous fatty acid vesicles under flow. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 14916-25. PMID 25402759 DOI: 10.1021/la503933x  0.8
2014 Budin I, Prwyes N, Zhang N, Szostak JW. Chain-length heterogeneity allows for the assembly of fatty acid vesicles in dilute solutions Biophysical Journal. 107: 1582-1590. PMID 25296310 DOI: 10.1016/j.bpj.2014.07.067  0.72
2014 Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW. Crystal structure studies of RNA duplexes containing s(2)U:A and s(2)U:U base pairs. Journal of the American Chemical Society. 136: 13916-24. PMID 25188906 DOI: 10.1021/ja508015a  0.48
2014 Blain JC, Szostak JW. Progress toward synthetic cells Annual Review of Biochemistry. 83: 615-640. PMID 24606140 DOI: 10.1146/annurev-biochem-080411-124036  0.88
2014 Jia TZ, Hentrich C, Szostak JW. Rapid RNA exchange in aqueous two-phase system and coacervate droplets. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 44: 1-12. PMID 24577897 DOI: 10.1007/s11084-014-9355-8  0.64
2014 Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW. Structural insights into the effects of 2'-5' linkages on the RNA duplex. Proceedings of the National Academy of Sciences of the United States of America. 111: 3050-5. PMID 24516151 DOI: 10.1073/pnas.1317799111  0.4
2014 Li L, Szostak JW. The free energy landscape of pseudorotation in 3′-5′ and 2′-5′ linked nucleic acids Journal of the American Chemical Society. 136: 2858-2865. PMID 24499340 DOI: 10.1021/ja412079b  0.6
2014 Blain JC, Ricardo A, Szostak JW. Synthesis and nonenzymatic template-directed polymerization of 2′-amino-2′-deoxythreose nucleotides Journal of the American Chemical Society. 136: 2033-2039. PMID 24409991 DOI: 10.1021/ja411950n  0.48
2014 Josephson K, Ricardo A, Szostak JW. MRNA display: From basic principles to macrocycle drug discovery Drug Discovery Today. 19: 388-399. PMID 24157402 DOI: 10.1016/j.drudis.2013.10.011  0.48
2013 Adamala K, Szostak JW. Nonenzymatic template-directed RNA synthesis inside model protocells Science. 342: 1098-1100. PMID 24288333 DOI: 10.1126/science.1241888  0.8
2013 Zhu TF, Budin I, Szostak JW. Preparation of fatty acid micelles Methods in Enzymology. 533: 283-288. PMID 24182934 DOI: 10.1016/B978-0-12-420067-8.00022-2  0.84
2013 Zhu TF, Budin I, Szostak JW. Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder Methods in Enzymology. 533: 275-282. PMID 24182933 DOI: 10.1016/B978-0-12-420067-8.00021-0  0.72
2013 Zhu TF, Budin I, Szostak JW. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration Methods in Enzymology. 533: 267-274. PMID 24182932 DOI: 10.1016/B978-0-12-420067-8.00020-9  0.88
2013 Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer Proceedings of the National Academy of Sciences of the United States of America. 110: 17732-17737. PMID 24101473 DOI: 10.1073/pnas.1312329110  0.24
2013 Adamala K, Szostak JW. Competition between model protocells driven by an encapsulated catalyst Nature Chemistry. 5: 495-501. PMID 23695631 DOI: 10.1038/nchem.1650  0.8
2013 Engelhart AE, Powner MW, Szostak JW. Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity. Nature Chemistry. 5: 390-4. PMID 23609089 DOI: 10.1038/nchem.1623  0.76
2013 Zhang S, Zhang N, Blain JC, Szostak JW. Synthesis of N3′-P5′-linked phosphoramidate DNA by nonenzymatic template-directed primer extension Journal of the American Chemical Society. 135: 924-932. PMID 23252395 DOI: 10.1021/ja311164j  0.56
2012 Budin I, Debnath A, Szostak JW. Concentration-driven growth of model protocell membranes Journal of the American Chemical Society. 134: 20812-20819. PMID 23198690 DOI: 10.1021/ja310382d  0.52
2012 Powner MW, Zheng SL, Szostak JW. Multicomponent assembly of proposed DNA precursors in water. Journal of the American Chemical Society. 134: 13889-95. PMID 22839703 DOI: 10.1021/ja306176n  0.52
2012 Zhu TF, Adamala K, Zhang N, Szostak JW. Photochemically driven redox chemistry induces protocell membrane pearling and division Proceedings of the National Academy of Sciences of the United States of America. 109: 9828-9832. PMID 22665773 DOI: 10.1073/pnas.1203212109  0.52
2012 Hofmann FT, Szostak JW, Seebeck FP. In vitro selection of functional lantipeptides Journal of the American Chemical Society. 134: 8038-8041. PMID 22545861 DOI: 10.1021/ja302082d  0.44
2012 Guillen Schlippe YV, Hartman MCT, Josephson K, Szostak JW. In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors Journal of the American Chemical Society. 134: 10469-10477. PMID 22428867 DOI: 10.1021/ja301017y  0.72
2012 Zhang N, Zhang S, Szostak JW. Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template Journal of the American Chemical Society. 134: 3691-3694. PMID 22296305 DOI: 10.1021/ja212027q  0.52
2012 Szostak JW. Attempts to define life do not help to understand the origin of life. Journal of Biomolecular Structure & Dynamics. 29: 599-600. PMID 22208251 DOI: 10.1080/073911012010524998  1
2011 Szostak JW. An optimal degree of physical and chemical heterogeneity for the origin of life? Philosophical Transactions of the Royal Society B: Biological Sciences. 366: 2894-2901. PMID 21930580 DOI: 10.1098/rstb.2011.0140  1
2011 Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity Proceedings of the National Academy of Sciences of the United States of America. 108: 13492-13497. PMID 21825162 DOI: 10.1073/pnas.1107113108  0.72
2011 Seebeck FP, Ricardo A, Szostak JW. Artificial lantipeptides from in vitro translations Chemical Communications. 47: 6141-6143. PMID 21528125 DOI: 10.1039/c0cc05663d  0.52
2011 Budin I, Szostak JW. Physical effects underlying the transition from primitive to modern cell membranes Proceedings of the National Academy of Sciences of the United States of America. 108: 5249-5254. PMID 21402937 DOI: 10.1073/pnas.1100498108  1
2011 Subtelny AO, Hartman MCT, Szostak JW. Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation Angewandte Chemie - International Edition. 50: 3164-3167. PMID 21381166 DOI: 10.1002/anie.201007686  0.72
2010 Powner MW, Sutherland JD, Szostak JW. Chemoselective multicomponent one-pot assembly of purine precursors in water. Journal of the American Chemical Society. 132: 16677-88. PMID 21043502 DOI: 10.1021/ja108197s  0.92
2010 Szostak JW. DNA ends: Just the beginning (Nobel lecture) Angewandte Chemie - International Edition. 49: 7386-7404. PMID 20818632 DOI: 10.1002/anie.201000635  1
2010 Elenko MP, Szostak JW, van Oijen AM. Single-molecule binding experiments on long time scales. The Review of Scientific Instruments. 81: 083705. PMID 20815611 DOI: 10.1063/1.3473936  0.8
2010 Schrum JP, Zhu TF, Szostak JW. The origins of cellular life. Cold Spring Harbor Perspectives in Biology. 2: a002212. PMID 20484387  0.72
2010 Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. Journal of the American Chemical Society. 132: 5880-5. PMID 20359213 DOI: 10.1021/ja100780p  0.28
2010 Budin I, Szostak JW. Expanding roles for diverse physical phenomena during the origin of life Annual Review of Biophysics. 39: 245-263. PMID 20192779 DOI: 10.1146/annurev.biophys.050708.133753  1
2009 Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophysical Journal. 97: 3113-22. PMID 20006948 DOI: 10.1016/j.bpj.2009.09.025  0.8
2009 Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2′-amino-2′,3′-dideoxyribonucleoside-5′- phosphorimidazolide monomers Journal of the American Chemical Society. 131: 14560-14570. PMID 19757789 DOI: 10.1021/ja906557v  0.8
2009 Mansy SS, Szostak JW. Reconstructing the emergence of cellular life through the synthesis of model protocells. Cold Spring Harbor Symposia On Quantitative Biology. 74: 47-54. PMID 19734203 DOI: 10.1101/sqb.2009.74.014  0.84
2009 Ricardo A, Szostak JW. Origin of life on earth Scientific American. 301: 54-61. PMID 19708528 DOI: 10.1038/scientificamerican0909-54  0.72
2009 Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy Journal of Physical Chemistry A. 113: 9585-9587. PMID 19673467 DOI: 10.1021/jp906746w  0.68
2009 Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. Journal of the American Chemical Society. 131: 9628-9. PMID 19601679 DOI: 10.1021/ja9029818  0.96
2009 Elenko MP, Szostak JW, van Oijen AM. Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics. Journal of the American Chemical Society. 131: 9866-7. PMID 19572753 DOI: 10.1021/ja901880v  0.56
2009 Szostak JW. Origins of life: Systems chemistry on early Earth Nature. 459: 171-172. PMID 19444196 DOI: 10.1038/459171a  0.96
2009 Litovchick A, Szostak JW. Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display". Proceedings of the National Academy of Sciences of the United States of America. 106: 7263. PMID 19380733  0.68
2009 Zhu TF, Szostak JW. Preparation of large monodisperse vesicles Plos One. 4. PMID 19347043 DOI: 10.1371/journal.pone.0005009  0.56
2009 Zhu TF, Szostak JW. Coupled growth and division of model protocell membranes. Journal of the American Chemical Society. 131: 5705-13. PMID 19323552 DOI: 10.1021/ja900919c  0.52
2009 Chen JJ, Tsai CH, Cai X, Horhota AT, McLaughlin LW, Szostak JW. Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. Plos One. 4: e4949. PMID 19305495 DOI: 10.1371/journal.pone.0004949  0.44
2009 Szostak J. Ray Wu, as remembered by a former student Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 52: 108-110. PMID 19277516 DOI: 10.1007/s11427-009-0023-6  0.01
2009 Chen JJ, Cai X, Szostak JW. N2′→ P3′ phosphoramidate glycerol nucleic acid as a potential alternative genetic system Journal of the American Chemical Society. 131: 2119-2121. PMID 19166350 DOI: 10.1021/ja809069b  0.32
2008 Litovchick A, Szostak JW. Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display Proceedings of the National Academy of Sciences of the United States of America. 105: 15293-15298. PMID 18824687 DOI: 10.1073/pnas.0805837105  0.56
2008 Mansy SS, Szostak JW. Thermostability of model protocell membranes Proceedings of the National Academy of Sciences of the United States of America. 105: 13351-13355. PMID 18768808 DOI: 10.1073/pnas.0805086105  0.96
2008 Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW. Template-directed synthesis of a genetic polymer in a model protocell Nature. 454: 122-125. PMID 18528332 DOI: 10.1038/nature07018  0.4
2008 Subtelny AO, Hartman MCT, Szostak JW. Ribosomal synthesis of N-methyl peptides Journal of the American Chemical Society. 130: 6131-6136. PMID 18402453 DOI: 10.1021/ja710016v  0.64
2008 Monnard PA, Szostak JW. Metal-ion catalyzed polymerization in the eutectic phase in water-ice: A possible approach to template-directed RNA polymerization Journal of Inorganic Biochemistry. 102: 1104-1111. PMID 18329104 DOI: 10.1016/j.jinorgbio.2008.01.026  0.64
2007 Hartman MCT, Josephson K, Lin CW, Szostak JW. An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides Plos One. 2. PMID 17912351 DOI: 10.1371/journal.pone.0000972  0.48
2007 Tsai CH, Chen J, Szostak JW. Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template Proceedings of the National Academy of Sciences of the United States of America. 104: 14598-14603. PMID 17785419 DOI: 10.1073/pnas.0704211104  0.52
2007 Seelig B, Szostak JW. Selection and evolution of enzymes from a partially randomized non-catalytic scaffold Nature. 448: 828-831. PMID 17700701 DOI: 10.1038/nature06032  0.44
2007 Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. Journal of Molecular Biology. 371: 501-13. PMID 17583732 DOI: 10.1016/j.jmb.2007.05.062  0.64
2007 Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: Importance of surface residues in protein fold optimization Plos One. 2. PMID 17520026 DOI: 10.1371/journal.pone.0000467  0.36
2007 Hazen RM, Griffin PL, Carothers JM, Szostak JW. Functional information and the emergence of biocomplexity Proceedings of the National Academy of Sciences of the United States of America. 104: 8574-8581. PMID 17494745 DOI: 10.1073/pnas.0701744104  0.64
2007 Meena, Sam M, Pierce K, Szostak JW, McLaughlin LW. 2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities. Organic Letters. 9: 1161-3. PMID 17319676 DOI: 10.1021/ol070147w  0.12
2007 Hanczyc MM, Mansy SS, Szostak JW. Mineral surface directed membrane assembly Origins of Life and Evolution of the Biosphere. 37: 67-82. PMID 16909329 DOI: 10.1007/s11084-006-9018-5  0.64
2006 Horhota AT, Szostak JW, McLaughlin LW. Glycerol nucleoside triphosphates: Synthesis and polymerase substrate activities Organic Letters. 8: 5345-5347. PMID 17078714 DOI: 10.1021/ol062232u  0.6
2006 Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nature Medicine. 12: 1133-8. PMID 17024208 DOI: 10.1038/nm1006-1133  0.28
2006 Salehi-Ashtiani K, Lupták A, Litovchick A, Szostak JW. A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene Science. 313: 1788-1792. PMID 16990549 DOI: 10.1126/science.1129308  0.56
2006 Carothers JM, Oestreich SC, Szostak JW. Aptamers selected for higher-affinity binding are not more specific for the target ligand Journal of the American Chemical Society. 128: 7929-7937. PMID 16771507 DOI: 10.1021/ja060952q  1
2006 Seebeck FP, Szostak JW. Ribosomal synthesis of dehydroalanine-containing peptides Journal of the American Chemical Society. 128: 7150-7151. PMID 16734454 DOI: 10.1021/ja060966w  0.68
2006 Hartman MCT, Josephson K, Szostak JW. Enzymatic aminoacylation of tRNA with unnatural amino acids Proceedings of the National Academy of Sciences of the United States of America. 103: 4356-4361. PMID 16537388 DOI: 10.1073/pnas.0509219103  0.64
2006 Carothers JM, Davis JH, Chou JJ, Szostak JW. Solution structure of an informationally complex high-affinity RNA aptamer to GTP. Rna (New York, N.Y.). 12: 567-79. PMID 16510427 DOI: 10.1261/rna.2251306  0.6
2006 Cho GS, Szostak JW. Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display Chemistry and Biology. 13: 139-147. PMID 16492562 DOI: 10.1016/j.chembiol.2005.10.015  0.88
2005 Plummer KA, Carothers JM, Yoshimura M, Szostak JW, Verdine GL. In vitro selection of RNA aptamers against a composite small molecule-protein surface. Nucleic Acids Research. 33: 5602-10. PMID 16199752 DOI: 10.1093/nar/gki867  0.36
2005 Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles Journal of the American Chemical Society. 127: 13213-13219. PMID 16173749 DOI: 10.1021/ja051784p  0.76
2005 Ichida JK, Horhota A, Zou K, McLaughlin LW, Szostak JW. High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Research. 33: 5219-25. PMID 16157867 DOI: 10.1093/nar/gki840  0.64
2005 Josephson K, Hartman MCT, Szostak JW. Ribosomal synthesis of unnatural peptides Journal of the American Chemical Society. 127: 11727-11735. PMID 16104750 DOI: 10.1021/ja0515809  0.44
2005 Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. Kinetic analysis of an efficient DNA-dependent TNA polymerase. Journal of the American Chemical Society. 127: 7427-34. PMID 15898792 DOI: 10.1021/ja0428255  0.52
2005 Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R. Scanning the human proteome for calmodulin-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 102: 5969-74. PMID 15840729 DOI: 10.1073/pnas.0407928102  0.24
2005 Sacerdote MG, Szostak JW. Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose Proceedings of the National Academy of Sciences of the United States of America. 102: 6004-6008. PMID 15831588 DOI: 10.1073/pnas.0408440102  0.8
2005 Zou K, Horhota A, Yu B, Szostak JW, McLaughlin LW. Synthesis of α-L-threofuranosyl nucleoside triphosphates (tNTPs) Organic Letters. 7: 1485-1487. PMID 15816733 DOI: 10.1021/ol050081+  0.52
2005 Ichida JK, Zou K, Horhota A, Yu B, McLaughlin LW, Szostak JW. An in vitro selection system for TNA. Journal of the American Chemical Society. 127: 2802-3. PMID 15740086 DOI: 10.1021/ja045364w  0.64
2004 Hanczyc MM, Szostak JW. Replicating vesicles as models of primitive cell growth and division Current Opinion in Chemical Biology. 8: 660-664. PMID 15556412 DOI: 10.1016/j.cbpa.2004.10.002  0.44
2004 Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science (New York, N.Y.). 305: 1474-6. PMID 15353806 DOI: 10.1126/science.1100757  0.92
2004 Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles Biophysical Journal. 87: 988-998. PMID 15298905 DOI: 10.1529/biophysj.104.039875  0.96
2004 Sazani PL, Larralde R, Szostak JW. A small aptamer with strong and specific recognition of the triphosphate of ATP Journal of the American Chemical Society. 126: 8370-8371. PMID 15237981 DOI: 10.1021/ja049171k  0.88
2004 Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability Chemistry and Biology. 11: 865-874. PMID 15217619 DOI: 10.1016/j.chembiol.2004.04.006  0.92
2004 Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles Proceedings of the National Academy of Sciences of the United States of America. 101: 7965-7970. PMID 15148394 DOI: 10.1073/pnas.0308045101  0.92
2004 Carothers JM, Oestreich SC, Davis JH, Szostak JW. Informational complexity and functional activity of RNA structures. Journal of the American Chemical Society. 126: 5130-7. PMID 15099096 DOI: 10.1021/ja031504a  0.8
2003 Huang Z, Szostak JW. Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. Rna (New York, N.Y.). 9: 1456-63. PMID 14624002 DOI: 10.1261/rna.5990203  0.56
2003 Hanczyc MM, Fujikawa SM, Szostak JW. Experimental models of primitive cellular compartments: encapsulation, growth, and division. Science (New York, N.Y.). 302: 618-22. PMID 14576428 DOI: 10.1126/science.1089904  0.56
2003 Chaput JC, Szostak JW. TNA synthesis by DNA polymerases Journal of the American Chemical Society. 125: 9274-9275. PMID 12889939 DOI: 10.1021/ja035917n  0.88
2003 Vaish NK, Larralde R, Fraley AW, Szostak JW, McLaughlin LW. A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality Biochemistry. 42: 8842-8851. PMID 12873145 DOI: 10.1021/bi027354i  0.44
2003 Szostak JW. Functional information: Molecular messages. Nature. 423: 689. PMID 12802312 DOI: 10.1038/423689a  0.96
2003 Huang Z, Szostak JW. Selective labeling and detection of specific RNAs in an RNA mixture. Analytical Biochemistry. 315: 129-33. PMID 12672421 DOI: 10.1016/S0003-2697(02)00701-7  0.48
2003 Chaput JC, Ichida JK, Szostak JW. DNA polymerase-mediated DNA synthesis on a TNA template. Journal of the American Chemical Society. 125: 856-7. PMID 12537469 DOI: 10.1021/ja028589k  0.92
2002 Szostak JW. Molecular biology: RNA gets a grip on translation. Nature. 419: 890-1. PMID 12410294 DOI: 10.1038/419890a  1
2002 Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW. Identification of epitope-like consensus motifs using mRNA display. Journal of Molecular Recognition : Jmr. 15: 126-34. PMID 12203838 DOI: 10.1002/jmr.567  0.44
2002 Davis JH, Szostak JW. Isolation of high-affinity GTP aptamers from partially structured RNA libraries. Proceedings of the National Academy of Sciences of the United States of America. 99: 11616-21. PMID 12185247 DOI: 10.1073/pnas.182095699  0.44
2001 Keefe AD, Wilson DS, Seelig B, Szostak JW. One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag. Protein Expression and Purification. 23: 440-6. PMID 11722181 DOI: 10.1006/prep.2001.1515  0.68
2001 Salehi-Ashtiani K, Szostak JW. In vitro evolution suggests multiple origins for the hammerhead ribozyme. Nature. 414: 82-4. PMID 11689947 DOI: 10.1038/35102081  0.64
2001 Keefe AD, Szostak JW. Functional proteins from a random-sequence library. Nature. 410: 715-8. PMID 11287961 DOI: 10.1038/35070613  0.6
2001 Wilson DS, Keefe AD, Szostak JW. The use of mRNA display to select high-affinity protein-binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 98: 3750-5. PMID 11274392 DOI: 10.1073/pnas.061028198  0.76
2001 Szostak JW, Bartel DP, Luisi PL. Synthesizing life. Nature. 409: 387-90. PMID 11201752 DOI: 10.1038/35053176  0.76
2000 Vaish NK, Fraley AW, Szostak JW, McLaughlin LW. Expanding the structural and functional diversity of RNA: Analog uridine triphosphates as candidates for in vitro selection of nucleic acids Nucleic Acids Research. 28: 3316-3322. PMID 10954600  0.44
2000 Liu R, Barrick JE, Szostak JW, Roberts RW. Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods in Enzymology. 318: 268-93. PMID 10889994  0.84
2000 Cho G, Keefe AD, Liu R, Wilson DS, Szostak JW. Constructing high complexity synthetic libraries of long ORFs using in vitro selection. Journal of Molecular Biology. 297: 309-19. PMID 10715203 DOI: 10.1006/jmbi.2000.3571  0.4
2000 Lee N, Bessho Y, Wei K, Szostak JW, Suga H. Ribozyme-catalyzed tRNA aminoacylation. Nature Structural Biology. 7: 28-33. PMID 10625423 DOI: 10.1038/71225  0.48
1999 Wilson DS, Szostak JW. In vitro selection of functional nucleic acids. Annual Review of Biochemistry. 68: 611-47. PMID 10872462 DOI: 10.1146/annurev.biochem.68.1.611  1
1998 Suga H, Lohse PA, Szostak JW. Structural and kinetic characterization of an acyl transferase ribozyme. Journal of the American Chemical Society. 120: 1151-6. PMID 11541113 DOI: 10.1021/ja972472s  0.88
1998 Holeman LA, Robinson SL, Szostak JW, Wilson C. Isolation and characterization of fluorophore-binding RNA aptamers. Folding & Design. 3: 423-31. PMID 9889155 DOI: 10.1016/S1359-0278(98)00059-5  0.4
1998 Wilson C, Szostak JW. Isolation of a fluorophore-specific DNA aptamer with weak redox activity. Chemistry & Biology. 5: 609-17. PMID 9831529  0.44
1998 Suga H, Cowan JA, Szostak JW. Unusual metal ion catalysis in an acyl-transferase ribozyme. Biochemistry. 37: 10118-25. PMID 9665717 DOI: 10.1021/bi980432a  0.6
1997 Szostak JW. In vitro selection and directed evolution. Harvey Lectures. 93: 95-118. PMID 10941421  1
1997 Roberts RW, Szostak JW. RNA-peptide fusions for the in vitro selection of peptides and proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 12297-302. PMID 9356443 DOI: 10.1073/pnas.94.23.12297  0.96
1997 Dieckmann T, Butcher SE, Sassanfar M, Szostak JW, Feigon J. Mutant ATP-binding RNA aptamers reveal the structural basis for ligand binding. Journal of Molecular Biology. 273: 467-78. PMID 9344753 DOI: 10.1006/jmbi.1997.1329  0.12
1997 Hager AJ, Szostak JW. Isolation of novel ribozymes that ligate AMP-activated RNA substrates. Chemistry & Biology. 4: 607-17. PMID 9281527  0.68
1996 Lorsch JR, Szostak JW. Chance and necessity in the selection of nucleic acid catalysts. Accounts of Chemical Research. 29: 103-10. PMID 11539421  0.96
1996 Rohatgi R, Bartel DP, Szostak JW. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. Journal of the American Chemical Society. 118: 3340-4. PMID 11539268  1
1996 Rohatgi R, Bartel DP, Szostak JW. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. Journal of the American Chemical Society. 118: 3332-9. PMID 11539267 DOI: 10.1021/ja953712b  1
1996 Hager AJ, Pollard JD, Szostak JW. Ribozymes: aiming at RNA replication and protein synthesis. Chemistry & Biology. 3: 717-25. PMID 8939686 DOI: 10.1016/S1074-5521(96)90246-X  0.64
1996 Huang Z, Szostak JW. A simple method for 3'-labeling of RNA. Nucleic Acids Research. 24: 4360-1. PMID 8932396 DOI: 10.1093/nar/24.21.4360  0.44
1996 Lohse PA, Szostak JW. Ribozyme-catalysed amino-acid transfer reactions. Nature. 381: 442-4. PMID 8632803 DOI: 10.1038/381442a0  0.72
1995 Lauhon CT, Szostak JW. RNA aptamers that bind flavin and nicotinamide redox cofactors. Journal of the American Chemical Society. 117: 1246-57. PMID 11539282  0.48
1995 Chapman KB, Szostak JW. Isolation of a ribozyme with 5'-5' ligase activity. Chemistry & Biology. 2: 325-33. PMID 9383434 DOI: 10.1016/1074-5521(95)90051-9  0.44
1995 Huizenga DE, Szostak JW. A DNA aptamer that binds adenosine and ATP. Biochemistry. 34: 656-65. PMID 7819261  0.96
1995 Cuenoud B, Szostak JW. A DNA metalloenzyme with DNA ligase activity. Nature. 375: 611-4. PMID 7791880 DOI: 10.1038/375611a0  0.48
1995 Wilson C, Szostak JW. In vitro evolution of a self-alkylating ribozyme. Nature. 374: 777-82. PMID 7723823 DOI: 10.1038/374777a0  0.64
1995 Whoriskey SK, Usman N, Szostak JW. Total chemical synthesis of a ribozyme derived from a group I intron. Proceedings of the National Academy of Sciences of the United States of America. 92: 2465-9. PMID 7708666 DOI: 10.1073/pnas.92.7.2465  0.56
1995 Ekland EH, Szostak JW, Bartel DP. Structurally complex and highly active RNA ligases derived from random RNA sequences. Science (New York, N.Y.). 269: 364-70. PMID 7618102  0.72
1995 Lorsch JR, Szostak JW. Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry. 34: 15315-27. PMID 7578148  1
1995 Lorsch JR, Bartel DP, Szostak JW. Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Research. 23: 2811-4. PMID 7544885 DOI: 10.1093/nar/23.15.2811  0.92
1994 Chapman KB, Szostak JW. In vitro selection of catalytic RNAs. Current Opinion in Structural Biology. 4: 618-22. PMID 11539575 DOI: 10.1016/S0959-440X(94)90227-5  0.52
1994 Peterson RD, Bartel DP, Szostak JW, Horvath SJ, Feigon J. 1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element. Biochemistry. 33: 5357-66. PMID 8180157  0.24
1994 Lin CW, Hanna M, Szostak JW. Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding. Biochemistry. 33: 2703-7. PMID 8117735  0.4
1994 Hanna M, Szostak JW. Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization. Nucleic Acids Research. 22: 5326-31. PMID 7816622  0.36
1994 Lorsch JR, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 371: 31-6. PMID 7521014 DOI: 10.1038/371031a0  0.96
1994 Lorsch JR, Szostak JW. In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry. 33: 973-82. PMID 7508262  0.92
1994 Green R, Szostak JW. In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron. Journal of Molecular Biology. 235: 140-55. PMID 7507168 DOI: 10.1016/S0022-2836(05)80022-1  0.96
1993 Bartel DP, Szostak JW. Isolation of new ribozymes from a large pool of random sequences [see comment]. Science (New York, N.Y.). 261: 1411-8. PMID 7690155  1
1993 Sassanfar M, Szostak JW. An RNA motif that binds ATP. Nature. 364: 550-3. PMID 7687750 DOI: 10.1038/364550a0  0.48
1993 Doudna JA, Usman N, Szostak JW. Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 32: 2111-5. PMID 7680575  0.76
1993 Szostak JW. Ribozymes. Evolution ex vivo. Nature. 361: 119-20. PMID 7678448 DOI: 10.1038/361119a0  1
1992 Park EC, Szostak JW. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. The Embo Journal. 11: 2087-93. PMID 1600941  0.64
1992 Ellington AD, Szostak JW. Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature. 355: 850-2. PMID 1538766 DOI: 10.1038/355850a0  1
1992 Green R, Szostak JW. Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science (New York, N.Y.). 258: 1910-5. PMID 1470913  1
1992 Ross LO, Treco D, Nicolas A, Szostak JW, Dawson D. Meiotic recombination on artificial chromosomes in yeast. Genetics. 131: 541-50. PMID 1385793  0.44
1992 Szostak JW. In vitro genetics. Trends in Biochemical Sciences. 17: 89-93. PMID 1384177 DOI: 10.1016/0968-0004(92)90242-2  1
1992 Park EC, Finley D, Szostak JW. A strategy for the generation of conditional mutations by protein destabilization. Proceedings of the National Academy of Sciences of the United States of America. 89: 1249-52. PMID 1311090  0.44
1991 Bartel DP, Doudna JA, Usman N, Szostak JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Molecular and Cellular Biology. 11: 3390-4. PMID 2038341  0.68
1991 Pace U, Szostak JW. Mutations in a semiconserved region of the Tetrahymena intron. Febs Letters. 280: 171-4. PMID 2009960 DOI: 10.1016/0014-5793(91)80230-Z  0.48
1991 Sun H, Treco D, Szostak JW. Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site. Cell. 64: 1155-61. PMID 2004421  0.48
1991 Schultes NP, Szostak JW. A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae. Molecular and Cellular Biology. 11: 322-8. PMID 1986228  0.76
1991 Sun H, Dawson D, Szostak JW. Genetic and physical analyses of sister chromatid exchange in yeast meiosis. Molecular and Cellular Biology. 11: 6328-36. PMID 1944292  0.52
1991 Bartel DP, Zapp ML, Green MR, Szostak JW. HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell. 67: 529-36. PMID 1934059  0.4
1991 Green R, Szostak JW, Benner SA, Rich A, Usman N. Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Research. 19: 4161-6. PMID 1714564 DOI: 10.1093/nar/19.15.4161  0.6
1991 Doudna JA, Couture S, Szostak JW. A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science (New York, N.Y.). 251: 1605-8. PMID 1707185  0.68
1990 Doudna JA, Szostak JW, Rich A, Usman N. Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. The Journal of Organic Chemistry. 55: 5547-9. PMID 11540922  0.48
1990 Lichten M, Goyon C, Schultes NP, Treco D, Szostak JW, Haber JE, Nicolas A. Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis. Proceedings of the National Academy of Sciences of the United States of America. 87: 7653-7. PMID 2217196  0.4
1990 Michel F, Ellington AD, Couture S, Szostak JW. Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns Nature. 347: 578-580. PMID 2215683  0.36
1990 Green R, Ellington AD, Szostak JW. In vitro genetic analysis of the Tetrahymena self-splicing intron. Nature. 347: 406-8. PMID 2215650 DOI: 10.1038/347406a0  0.96
1990 Schultes NP, Ellington AD, Cherry JM, Szostak JW. Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene. 96: 177-80. PMID 2176637 DOI: 10.1016/0378-1119(90)90250-U  0.64
1990 Park EC, Szostak JW. Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML Molecular and Cellular Biology. 10: 4932-4934. PMID 2117703  0.64
1990 Schultes NP, Szostak JW. Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast Genetics. 126: 813-822. PMID 1981763  0.6
1990 Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. Journal of Molecular Biology. 215: 345-58. PMID 1700131  0.48
1990 Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands Nature. 346: 818-822. PMID 1697402  1
1989 Szostak JW. The beginning of the ends Nature. 337: 303-304. PMID 2765013  1
1989 Michel F, Hanna M, Green R, Bartel DP, Szostak JW. The guanosine binding site of the Tetrahymena ribozyme. Nature. 342: 391-5. PMID 2685606 DOI: 10.1038/342391a0  0.48
1989 Doudna JA, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Molecular and Cellular Biology. 9: 5480-3. PMID 2685567  0.96
1989 Doudna JA, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proceedings of the National Academy of Sciences of the United States of America. 86: 7402-6. PMID 2678103  0.72
1989 Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature. 339: 519-22. PMID 2660003 DOI: 10.1038/339519a0  0.96
1989 Lundblad V, Szostak JW. A mutant with a defect in telomere elongation leads to senescence in yeast Cell. 57: 633-643. PMID 2655926 DOI: 10.1016/0092-8674(89)90132-3  0.56
1989 Sun H, Treco D, Schultes NP, Szostak JW. Double-strand breaks at an initiation site for meiotic gene conversion Nature. 338: 87-90. PMID 2645528  0.4
1989 Nicolas A, Treco D, Schultes NP, Szostak JW. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature. 338: 35-9. PMID 2537472 DOI: 10.1038/338035a0  0.48
1989 Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science (New York, N.Y.). 244: 692-4. PMID 2470151  0.68
1988 Orr-Weaver TL, Nicolas A, Szostak JW. Gene conversion adjacent to regions of double-strand break repair. Molecular and Cellular Biology. 8: 5292-8. PMID 3072478 DOI: 10.1128/MCB.8.12.5292  0.56
1988 Murray AW, Claus TE, Szostak JW. Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Molecular and Cellular Biology. 8: 4642-50. PMID 3062364  0.8
1988 Allshire RC, Gosden JR, Cross SH, Cranston G, Rout D, Sugawara N, Szostak JW, Fantes PA, Hastie ND. Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature. 332: 656-9. PMID 2833706 DOI: 10.1038/332656a0  0.16
1988 Matsumoto T, Fukui K, Niwa O, Sugawara N, Szostak JW, Yanagida M. Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Molecular and Cellular Biology. 7: 4424-30. PMID 2830493 DOI: 10.1128/MCB.7.12.4424  0.24
1987 Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns Nucleic Acids Research. 15: 7217-7221. PMID 3658691 DOI: 10.1093/nar/15.18.7217  0.24
1987 Murray AW, Szostak JW. Artificial chromosomes. Scientific American. 257: 62-8. PMID 3317814  1
1987 Whiteway M, Freedman R, Van Arsdell S, Szostak JW, Thorner J. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Molecular and Cellular Biology. 7: 3713-22. PMID 3316986 DOI: 10.1128/MCB.7.10.3713  0.32
1987 Reynolds AE, Murray AW, Szostak JW. Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. Molecular and Cellular Biology. 7: 3566-73. PMID 3316982  0.64
1987 Doudna JA, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harbor Symposia On Quantitative Biology. 52: 173-80. PMID 2456876  0.64
1986 Murray AW, Szostak JW. Construction and behavior of circularly permuted and telocentric chromosomes in Saccharomyces cerevisiae. Molecular and Cellular Biology. 6: 3166-72. PMID 3537731  0.92
1986 Dawson DS, Murray AW, Szostak JW. An alternative pathway for meiotic chromosome segregation in yeast. Science (New York, N.Y.). 234: 713-7. PMID 3535068  1
1986 Murray AW, Schultes NP, Szostak JW. Chromosome length controls mitotic chromosome segregation in yeast. Cell. 45: 529-36. PMID 3518944  0.8
1986 Szostak JW. Enzymatic activity of the conserved core of a group I self-splicing intron. Nature. 322: 83-6. PMID 3014350 DOI: 10.1038/322083a0  0.72
1985 Ruby SW, Szostak JW. Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Molecular and Cellular Biology. 5: 75-84. PMID 3920512 DOI: 10.1128/MCB.5.1.75  0.92
1985 Murray AW, Szostak JW. Chromosome segregation in mitosis and meiosis. Annual Review of Cell Biology. 1: 289-315. PMID 3916318 DOI: 10.1146/annurev.cb.01.110185.001445  1
1985 Whiteway M, Szostak JW. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways Cell. 43: 483-492. PMID 3907857 DOI: 10.1016/0092-8674(85)90178-3  0.68
1985 Orr-Weaver TL, Szostak JW. Fungal recombination. Microbiological Reviews. 49: 33-58. PMID 3884994  0.96
1984 Shampay J, Szostak JW, Blackburn EH. DNA sequences of telomeres maintained in yeast. Nature. 310: 154-7. PMID 6330571 DOI: 10.1038/310154a0  0.36
1984 Dunn B, Szauter P, Pardue ML, Szostak JW. Transfer of yeast telomeres to linear plasmids by recombination. Cell. 39: 191-201. PMID 6091911 DOI: 10.1016/0092-8674(84)90205-8  0.56
1983 Szostak JW, Orr-Weaver TL, Rothstein RJ, Stahl FW. The double-strand-break repair model for recombination. Cell. 33: 25-35. PMID 6380756 DOI: 10.1016/0092-8674(83)90331-8  0.64
1983 Murray AW, Szostak JW. Pedigree analysis of plasmid segregation in yeast. Cell. 34: 961-70. PMID 6354471  1
1983 Sugawara N, Szostak JW. Recombination between sequences in nonhomologous positions. Proceedings of the National Academy of Sciences of the United States of America. 80: 5675-9. PMID 6351064 DOI: 10.1073/pnas.80.18.5675  0.48
1983 Murray AW, Szostak JW. Construction of artificial chromosomes in yeast. Nature. 305: 189-93. PMID 6350893  0.96
1983 Orr-Weaver TL, Szostak JW. Multiple, tandem plasmid integration in Saccharomyces cerevisiae. Molecular and Cellular Biology. 3: 747-9. PMID 6343844 DOI: 10.1128/MCB.3.4.747  0.96
1983 Walmsley RM, Szostak JW, Petes TD. Is there left-handed DNA at the ends of yeast chromosomes? Nature. 302: 84-86. PMID 6338397 DOI: 10.1038/302084a0  0.44
1983 Brown PA, Szostak JW. Yeast vectors with negative selection Methods in Enzymology. 278-289. PMID 6310330 DOI: 10.1016/0076-6879(83)01021-6  0.48
1983 Sugawara N, Szostak JW. Construction of specific chromosomal rearrangements in yeast. Methods in Enzymology. 101: 269-78. PMID 6310329 DOI: 10.1016/0076-6879(83)01020-4  0.48
1983 Ruby SW, Szostak JW, Murray AW. Cloning regulated yeast genes from a pool of lacZ fusions. Methods in Enzymology. 101: 253-69. PMID 6310328 DOI: 10.1016/0076-6879(83)01019-8  0.92
1983 Szostak JW. A rapid procedure for the construction of linear yeast plasmids. Methods in Enzymology. 101: 245-52. PMID 6310327 DOI: 10.1016/0076-6879(83)01018-6  0.64
1983 Orr-Weaver TL, Szostak JW, Rothstein RJ. Genetic applications of yeast transformation with linear and gapped plasmids. Methods in Enzymology. 101: 228-45. PMID 6310326 DOI: 10.1016/0076-6879(83)01017-4  0.8
1983 Orr-Weaver TL, Szostak JW. Yeast recombination: the association between double-strand gap repair and crossing-over. Proceedings of the National Academy of Sciences of the United States of America. 80: 4417-21. PMID 6308623 DOI: 10.1073/pnas.80.14.4417  1
1983 Szostak JW. Replication and resolution of telomeres in yeast. Cold Spring Harbor Symposia On Quantitative Biology. 1187-94. PMID 6305577 DOI: 10.1101/SQB.1983.047.01.134  0.76
1982 Szostak JW, Blackburn EH. Cloning yeast telomeres on linear plasmid vectors. Cell. 29: 245-55. PMID 6286143 DOI: 10.1016/0092-8674(82)90109-X  0.36
1981 Orr-Weaver TL, Szostak JW, Rothstein RJ. Yeast transformation: a model system for the study of recombination. Proceedings of the National Academy of Sciences of the United States of America. 78: 6354-8. PMID 6273866 DOI: 10.1073/pnas.78.10.6354  0.68
1981 Stiles JI, Szostak JW, Young AT, Wu R, Consaul S, Sherman F. DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA. Cell. 25: 277-84. PMID 6268305 DOI: 10.1016/0092-8674(81)90253-1  0.12
1980 Szostak JW, Wu R. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature. 284: 426-30. PMID 6987539 DOI: 10.1038/284426a0  0.52
1980 Szostak JW, Wu R. Insertion of a genetic marker into the ribosomal DNA of yeast. Plasmid. 2: 536-54. PMID 394173 DOI: 10.1016/0147-619X(79)90053-2  0.48
1979 Szostak JW, Stiles JI, Tye BK, Chiu P, Sherman F, Wu R. [29] Hybridization with synthetic oligonucleotides Methods in Enzymology. 68: 419-428. PMID 161605 DOI: 10.1016/0076-6879(79)68031-X  0.12
1977 Szostak JW, Stiles JI, Bahl CP, Wu R. Specific binding of a synthetic oligodeoxyribonucleotide to yeast cytochrome c mRNA. Nature. 265: 61-3. PMID 189200 DOI: 10.1038/265061a0  0.2
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