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Ronald A. DePinho, MD - Publications

Affiliations: 
President University of Texas MD Anderson Cancer Center, Houston, TX, United States 
Area:
molecular and biological processes governing the development of cancer, the basis for aging and degenerative diseases, and the maintenance of normal and cancer stem cells.
Website:
http://www.dfhcc.harvard.edu/membership/profile/member/107/0/

319 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, ... DePinho RA, et al. USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation. Genes & Development. PMID 31488580 DOI: 10.1101/gad.326314.119  0.4
2019 Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 35: 868-884.e6. PMID 31185211 DOI: 10.1016/j.ccell.2019.05.003  0.4
2019 Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, ... ... DePinho RA, et al. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. PMID 30918400 DOI: 10.1038/s41586-019-1062-1  0.4
2019 Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, ... ... DePinho RA, et al. KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. Cancer Cell. PMID 30905761 DOI: 10.1016/j.ccell.2019.02.008  0.4
2019 Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, ... ... DePinho RA, et al. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Reports. 26: 469-482.e5. PMID 30625329 DOI: 10.1016/j.celrep.2018.12.043  0.36
2018 Son DH, Doan KV, Yang DJ, Sun JS, Kim SK, Kang N, Kang JY, Paik JH, DePinho RA, Choi YH, Shin DM, Kim KW. FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. Metabolism: Clinical and Experimental. PMID 30500562 DOI: 10.1016/j.metabol.2018.11.013  0.52
2018 Moreira D, Adamus T, Zhao X, Su YL, Zhang Z, White SV, Swiderski P, Lu X, DePinho RA, Pal SK, Kortylewski M. STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30337279 DOI: 10.1158/1078-0432.CCR-18-1277  0.44
2018 Wang G, Zhao D, Spring DJ, DePinho RA. Genetics and biology of prostate cancer. Genes & Development. 32: 1105-1140. PMID 30181359 DOI: 10.1101/gad.315739.118  0.4
2018 Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, ... ... DePinho RA, et al. An in vivo screen identifies PYGO2 as a driver for metastatic prostate cancer. Cancer Research. PMID 29769196 DOI: 10.1158/0008-5472.CAN-17-3564  0.4
2018 Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, ... ... DePinho RA, et al. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 33: 152. PMID 29316430 DOI: 10.1016/j.ccell.2017.12.012  0.36
2017 Lu X, Jin EJ, Cheng X, Feng S, Shang X, Deng P, Jiang S, Chang Q, Rahmy S, Chaudhary S, Lu X, Zhao R, Wang YA, DePinho RA. Opposing roles of TGFβ and BMP signaling in prostate cancer development. Genes & Development. 31: 2337-2342. PMID 29352019 DOI: 10.1101/gad.307116.117  0.4
2017 Ong DST, Hu B, Ho YW, Sauvé CG, Bristow CA, Wang Q, Multani AS, Chen P, Nezi L, Jiang S, Gorman CE, Monasterio MM, Koul D, Marchesini M, Colla S, ... ... DePinho RA, et al. PAF promotes stemness and radioresistance of glioma stem cells. Proceedings of the National Academy of Sciences of the United States of America. 114: E9086-E9095. PMID 29073105 DOI: 10.1073/pnas.1708122114  0.48
2017 Yang Y, Blee AM, Wang D, An J, Pan Y, Yan Y, Ma T, He Y, Dugdale J, Hou X, Zhang J, Weroha SJ, Zhu WG, Wang YA, DePinho RA, et al. Loss of FOXO1 cooperates with TMPRSS2-ERG overexpression to promote prostate tumorigenesis and cell invasion. Cancer Research. PMID 28986382 DOI: 10.1158/0008-5472.CAN-17-0686  0.36
2017 Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, ... ... DePinho RA, et al. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 32: 42-56.e6. PMID 28697342 DOI: 10.1016/j.ccell.2017.06.003  0.36
2017 Zhao D, DePinho RA. Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 28675450 DOI: 10.1002/bies.201700076  0.36
2017 Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D'Anca M, Storti P, Samur MK, Ganan-Gomez I, Fulciniti MT, Mistry N, Jiang S, Bao N, Marchica V, Neri A, ... ... DePinho RA, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. PMID 28669490 DOI: 10.1016/j.ccell.2017.05.011  0.32
2017 Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 545: 116. PMID 28470201 DOI: 10.1038/nature22348  0.4
2017 Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, et al. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. American Journal of Cancer Research. 7: 657-672. PMID 28401019  0.32
2017 Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. PMID 28321130 DOI: 10.1038/nature21676  0.4
2017 Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, ... ... DePinho RA, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes & Development. PMID 28289141 DOI: 10.1101/gad.293449.116  0.4
2017 Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, ... DePinho RA, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nature Communications. 8: 14437. PMID 28232723 DOI: 10.1038/ncomms14437  0.36
2017 Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, ... ... DePinho RA, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. PMID 28178232 DOI: 10.1038/nature21064  0.4
2017 Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, ... ... DePinho RA, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. PMID 28166537 DOI: 10.1038/nature21357  0.4
2017 Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, ... ... DePinho RA, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. PMID 28099419 DOI: 10.1038/nature21052  0.4
2016 Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, ... ... DePinho RA, et al. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 167: 1281-1295.e18. PMID 27863244 DOI: 10.1016/j.cell.2016.10.039  0.4
2016 Doan KV, Kinyua AW, Yang DJ, Ko CM, Moh SH, Shong KE, Kim H, Park SK, Kim DH, Kim I, Paik JH, DePinho RA, Yoon SG, Kim IY, Seong JK, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nature Communications. 7: 12733. PMID 27681312 DOI: 10.1038/ncomms12733  0.48
2016 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. Journal of Immunology (Baltimore, Md. : 1950). 196: 3514-6. PMID 27183648  0.32
2016 Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Development. 30: 355-85. PMID 26883357 DOI: 10.1101/gad.275776.115  1
2015 Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends in Cancer. 1: 161-173. PMID 26870836 DOI: 10.1016/j.trecan.2015.10.002  1
2015 Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, ... ... DePinho RA, et al. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Cancer Discovery. PMID 26701088 DOI: 10.1158/2159-8290.CD-15-0224  1
2015 Taguchi A, Rho JH, Yan Q, Zhang Y, Zhao Y, Xu H, Tripathi SC, Wang H, Brenner D, Kucherlapati M, Kucherlapati RS, Boutin A, Wang YA, DePinho RA, Feng Z, et al. MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prevention Research (Philadelphia, Pa.). PMID 26342024 DOI: 10.1158/1940-6207.CAPR-15-0077  1
2015 Eelen G, Verlinden L, Maes C, Beullens I, Gysemans C, Paik JH, DePinho RA, Bouillon R, Carmeliet G, Verstuyf A. Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26232637 DOI: 10.1016/j.jsbmb.2015.07.015  1
2015 Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, ... ... DePinho RA, et al. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. PMID 26153864 DOI: 10.1038/nature14609  0.4
2015 Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, ... ... DePinho RA, et al. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 27: 644-57. PMID 25965571 DOI: 10.1016/j.ccell.2015.04.007  1
2015 O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature Communications. 6: 7079. PMID 25963540 DOI: 10.1038/ncomms8079  1
2015 Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nature Communications. 6: 6670. PMID 25858807 DOI: 10.1038/ncomms7670  1
2015 Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, ... ... DePinho RA, et al. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Research. 75: 1091-101. PMID 25736685 DOI: 10.1158/0008-5472.CAN-14-1854  1
2015 Daemen A, Peterson D, Sahu N, McCord R, Du X, Liu B, Kowanetz K, Hong R, Moffat J, Gao M, Boudreau A, Mroue R, Corson L, O'Brien T, Qing J, ... ... DePinho RA, et al. Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors Proceedings of the National Academy of Sciences of the United States of America. 112: E4410-E4417. DOI: 10.1073/pnas.1501605112  1
2014 Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes & Cancer. 5: 306-19. PMID 25352948  1
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, ... ... DePinho RA, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/nature13611  1
2014 Ying H, DePinho RA. Cancer signaling: when phosphorylation meets methylation. Cell Research. 24: 1282-3. PMID 25104733 DOI: 10.1038/cr.2014.103  1
2014 Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 26: 14-5. PMID 25026209 DOI: 10.1016/j.ccr.2014.06.003  1
2014 Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, ... ... DePinho RA, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes & Development. 28: 1429-44. PMID 24990963 DOI: 10.1101/gad.242131.114  1
2014 Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, ... ... DePinho RA, et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 158: 185-97. PMID 24954535 DOI: 10.1016/j.cell.2014.06.003  1
2014 Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Science Signaling. 7: ra18. PMID 24570486 DOI: 10.1126/scisignal.2004809  1
2014 Stopczynski RE, Normolle DP, Hartman DJ, Ying H, DeBerry JJ, Bielefeldt K, Rhim AD, DePinho RA, Albers KM, Davis BM. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Research. 74: 1718-27. PMID 24448244 DOI: 10.1158/0008-5472.CAN-13-2050  1
2013 Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Reports. 5: 314-22. PMID 24209743 DOI: 10.1016/j.celrep.2013.09.026  1
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/j.cell.2013.09.025  1
2013 Hua Y, White-Gilbertson S, Kellner J, Rachidi S, Usmani SZ, Chiosis G, Depinho R, Li Z, Liu B. Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma Clinical Cancer Research. 19: 6242-6251. PMID 24077352 DOI: 10.1158/1078-0432.CCR-13-2083  1
2013 Xiong X, Tao R, DePinho RA, Dong XC. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. Plos One. 8: e74340. PMID 24015318 DOI: 10.1371/journal.pone.0074340  1
2013 Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. The Journal of Biological Chemistry. 288: 29252-9. PMID 23974119 DOI: 10.1074/jbc.M113.481473  1
2013 Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 14520-7. PMID 23918370 DOI: 10.1073/pnas.1308610110  1
2013 Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. Journal of Lipid Research. 54: 2745-53. PMID 23881913 DOI: 10.1194/jlr.M039339  1
2013 Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM. Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nature Cell Biology. 15: 895-904. PMID 23831727 DOI: 10.1038/ncb2790  1
2013 Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia (New York, N.Y.). 15: 684-93. PMID 23814481 DOI: 10.1593/neo.13276  1
2013 Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster F, Ying H, Zheng H, Xiao Y, Chen Z, Protopopov A, Depinho RA, Paik JH. ZNF365 promotes stability of fragile sites and telomeres. Cancer Discovery. 3: 798-811. PMID 23776040 DOI: 10.1158/2159-8290.CD-12-0536  1
2013 Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Guo EX, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metabolism. 17: 901-15. PMID 23684624 DOI: 10.1016/j.cmet.2013.04.009  1
2013 Roudier E, Milkiewicz M, Birot O, Slopack D, Montelius A, Gustafsson T, Paik JH, DePinho RA, Casale GP, Pipinos II, Haas TL. Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis. 16: 759-72. PMID 23677673 DOI: 10.1007/s10456-013-9353-x  1
2013 Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, et al. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes & Development. 27: 916-27. PMID 23630076 DOI: 10.1101/gad.214049.113  1
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... DePinho RA, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/nature12040  1
2013 Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood. 121: 3619-30. PMID 23444404 DOI: 10.1182/blood-2012-08-448290  1
2013 Kopycinska J, KempiÅ„ska-Podhorodecka A, Haas T, Elias E, DePinho RA, Paik J, Milkiewicz P, Milkiewicz M. Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 231-8. PMID 23295054 DOI: 10.1111/liv.12030  1
2013 Gallagher SJ, Kofman AE, Huszar JM, Dannenberg JH, DePinho RA, Braun RE, Payne CJ. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Developmental Biology. 373: 83-94. PMID 23085237 DOI: 10.1016/j.ydbio.2012.10.009  1
2012 Xiong X, Tao R, DePinho RA, Dong XC. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. The Journal of Biological Chemistry. 287: 39107-14. PMID 22992773 DOI: 10.1074/jbc.M112.412569  1
2012 Shi X, Wallis AM, Gerard RD, Voelker KA, Grange RW, DePinho RA, Garry MG, Garry DJ. Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. Journal of Cell Science. 125: 5329-37. PMID 22956541 DOI: 10.1242/jcs.105239  1
2012 Lu X, Agasti SS, Vinegoni C, Waterman P, DePinho RA, Weissleder R. Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjugate Chemistry. 23: 1945-51. PMID 22917215 DOI: 10.1021/bc300319c  1
2012 Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, ... ... DePinho RA, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 488: 337-42. PMID 22895339 DOI: 10.1038/nature11331  1
2012 Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proceedings of the National Academy of Sciences of the United States of America. 109: 14164-9. PMID 22891331 DOI: 10.1073/pnas.1211962109  1
2012 Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, ... ... Depinho RA, et al. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes & Development. 26: 1459-72. PMID 22751500 DOI: 10.1101/gad.189001.112  1
2012 Kim KW, Donato J, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK. FOXO1 in the ventromedial hypothalamus regulates energy balance. The Journal of Clinical Investigation. 122: 2578-89. PMID 22653058 DOI: 10.1172/JCI62848  1
2012 Sahin E, DePinho RA. Axis of ageing: telomeres, p53 and mitochondria. Nature Reviews. Molecular Cell Biology. 13: 397-404. PMID 22588366 DOI: 10.1038/nrm3352  1
2012 Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG, White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism. 15: 703-12. PMID 22560222 DOI: 10.1016/j.cmet.2012.04.011  1
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, ... ... DePinho RA, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/j.cell.2012.01.058  1
2012 Moslehi J, DePinho RA, Sahin E. Telomeres and mitochondria in the aging heart. Circulation Research. 110: 1226-37. PMID 22539756 DOI: 10.1161/CIRCRESAHA.111.246868  1
2012 Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes & Development. 26: 756-84. PMID 22508724 DOI: 10.1101/gad.187922.112  1
2012 Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nature Genetics. 44: 406-12, S1. PMID 22406641 DOI: 10.1038/ng.2215  1
2012 Tsuchiya K, Tanaka J, Shuiqing Y, Welch CL, DePinho RA, Tabas I, Tall AR, Goldberg IJ, Accili D. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metabolism. 15: 372-81. PMID 22405072 DOI: 10.1016/j.cmet.2012.01.018  1
2012 Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, ... ... DePinho RA, et al. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 148: 896-907. PMID 22341455 DOI: 10.1016/j.cell.2012.01.039  1
2012 Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, ... ... DePinho RA, et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 148: 651-63. PMID 22341440 DOI: 10.1016/j.cell.2011.12.028  1
2012 Poché RA, Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik JH, DePinho RA, Bartlett JD, Dickinson ME. Transcription factor FoxO1 is essential for enamel biomineralization. Plos One. 7: e30357. PMID 22291941 DOI: 10.1371/journal.pone.0030357  1
2012 DePinho R. Straight talk with... Ronald DePinho. Interview by Rebecca Hersher Nature Medicine. 18: 9. PMID 22227654  1
2012 Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology. 153: 631-46. PMID 22147007 DOI: 10.1210/en.2011-1527  1
2011 Martin NE, Mucci LA, Loda M, Depinho RA. Prognostic determinants in prostate cancer. Cancer Journal (Sudbury, Mass.). 17: 429-37. PMID 22157287 DOI: 10.1097/PPO.0b013e31823b042c  1
2011 Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, ... ... DePinho RA, et al. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer Discovery. 1: 158-69. PMID 21984975 DOI: 10.1158/2159-8290.CD-11-0031  1
2011 Cao Y, DePinho RA, Ernst M, Vousden K. Cancer research: past, present and future. Nature Reviews. Cancer. 11: 749-54. PMID 21918542 DOI: 10.1038/nrc3138  1
2011 Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, ... Depinho RA, et al. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 20: 289-99. PMID 21907921 DOI: 10.1016/j.ccr.2011.08.007  1
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Depinho RA, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/ng.936  1
2011 Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, ... ... DePinho RA, et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 146: 697-708. PMID 21884932 DOI: 10.1016/j.cell.2011.07.032  1
2011 Draetta GF, Depinho RA. Cancer drug discovery faces the FACT. Science Translational Medicine. 3: 95ps34. PMID 21832237 DOI: 10.1126/scitranslmed.3002822  1
2011 Scott KL, Nogueira C, Heffernan TP, van Doorn R, Dhakal S, Hanna JA, Min C, Jaskelioff M, Xiao Y, Wu CJ, Cameron LA, Perry SR, Zeid R, Feinberg T, Kim M, ... ... DePinho RA, et al. Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell. 20: 92-103. PMID 21741599 DOI: 10.1016/j.ccr.2011.05.025  1
2011 Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 118: 1264-73. PMID 21653327 DOI: 10.1182/blood-2011-01-328567  1
2011 Tao R, Wei D, Gao H, Liu Y, DePinho RA, Dong XC. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. The Journal of Biological Chemistry. 286: 14681-90. PMID 21388966 DOI: 10.1074/jbc.M110.201061  1
2011 Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, ... ... DePinho RA, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 471: 104-9. PMID 21368833 DOI: 10.1038/nature09732  1
2011 Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, ... ... DePinho RA, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 470: 359-65. PMID 21307849 DOI: 10.1038/nature09787  1
2011 Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, ... DePinho RA, et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 144: 601-13. PMID 21295337 DOI: 10.1016/j.cell.2011.01.011  1
2011 Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, ... ... DePinho RA, et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 470: 269-73. PMID 21289624 DOI: 10.1038/nature09677  1
2011 Stegh AH, DePinho RA. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle (Georgetown, Tex.). 10: 33-8. PMID 21200141 DOI: 10.4161/cc.10.1.14365  1
2011 Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of Biological Chemistry. 286: 7468-78. PMID 21159781 DOI: 10.1074/jbc.M110.179242  1
2011 Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 469: 102-6. PMID 21113150 DOI: 10.1038/nature09603  1
2010 Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 468: 701-4. PMID 21124456 DOI: 10.1038/nature09595  1
2010 Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, ... ... DePinho RA, et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 18: 472-84. PMID 21075312 DOI: 10.1016/j.ccr.2010.10.019  1
2010 Dentice M, Marsili A, Ambrosio R, Guardiola O, Sibilio A, Paik JH, Minchiotti G, DePinho RA, Fenzi G, Larsen PR, Salvatore D. The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. The Journal of Clinical Investigation. 120: 4021-30. PMID 20978344 DOI: 10.1172/JCI43670  1
2010 Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circulation Research. 107: 1470-82. PMID 20947830 DOI: 10.1161/CIRCRESAHA.110.227371  1
2010 Stegh AH, Brennan C, Mahoney JA, Forloney KL, Jenq HT, Luciano JP, Protopopov A, Chin L, Depinho RA. Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes & Development. 24: 2194-204. PMID 20837658 DOI: 10.1101/gad.1924710  1
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... DePinho RA, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  1
2010 Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes & Development. 24: 1731-45. PMID 20713517 DOI: 10.1101/gad.1890510  1
2010 Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 29: 5809-17. PMID 20697345 DOI: 10.1038/onc.2010.314  1
2010 Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 142: 296-308. PMID 20655470 DOI: 10.1016/j.cell.2010.06.003  1
2010 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE. Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (Dayton, Ohio). 28: 1424-34. PMID 20572009 DOI: 10.1002/stem.464  1
2010 Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, van der Torre J, DePinho RA, Dannenberg JH. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. The Embo Journal. 29: 2586-97. PMID 20571512 DOI: 10.1038/emboj.2010.136  1
2010 Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, et al. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. Plos One. 5: e10767. PMID 20532243 DOI: 10.1371/journal.pone.0010767  1
2010 Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, ... ... DePinho RA, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 17: 497-509. PMID 20478531 DOI: 10.1016/j.ccr.2010.03.020  1
2010 Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nature Immunology. 11: 618-27. PMID 20467422 DOI: 10.1038/ni.1884  1
2010 Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. The Journal of Experimental Medicine. 207: 1381-91. PMID 20439537 DOI: 10.1084/jem.20100004  1
2010 Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, ... ... DePinho RA, ... ... DePinho RA, et al. International network of cancer genome projects. Nature. 464: 993-8. PMID 20393554 DOI: 10.1038/nature08987  0.4
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  1
2010 Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, ... ... DePinho RA, et al. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6912-7. PMID 20351267 DOI: 10.1073/pnas.0914930107  1
2010 Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 464: 520-8. PMID 20336134 DOI: 10.1038/nature08982  1
2010 Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA, Kousteni S. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metabolism. 11: 147-60. PMID 20142102 DOI: 10.1016/j.cmet.2010.01.001  1
2010 Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metabolism. 11: 136-46. PMID 20142101 DOI: 10.1016/j.cmet.2009.12.009  1
2010 Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. The Journal of Clinical Investigation. 120: 357-68. PMID 20038793 DOI: 10.1172/JCI39901  1
2010 Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, et al. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nature Biotechnology. 28: 71-8. PMID 20023657 DOI: 10.1038/nbt.1595  1
2010 Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis. 31: 9-18. PMID 19887512 DOI: 10.1093/carcin/bgp268  1
2010 Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice (Journal of Clinical Investigation (2010) 120, 1 (357-368) (DOI:10.1172/JCI39901)) Journal of Clinical Investigation. 120: 932. DOI: 10.1172/JCI37672E1  1
2009 Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, ... ... DePinho RA, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 5: 540-53. PMID 19896444 DOI: 10.1016/j.stem.2009.09.013  1
2009 Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K. PI3 kinase signals BCR-dependent mature B cell survival. Cell. 139: 573-86. PMID 19879843 DOI: 10.1016/j.cell.2009.08.041  1
2009 Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 16: 379-89. PMID 19878870 DOI: 10.1016/j.ccr.2009.09.027  1
2009 Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine. 15: 1307-11. PMID 19838201 DOI: 10.1038/nm.2049  1
2009 Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nature Medicine. 15: 1195-201. PMID 19767734 DOI: 10.1038/nm.2026  1
2009 Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S. Brain metastasis: opportunities in basic and translational research. Cancer Research. 69: 6015-20. PMID 19638593 DOI: 10.1158/0008-5472.CAN-08-4347  1
2009 Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 58: 2344-54. PMID 19584310 DOI: 10.2337/db09-0167  1
2009 Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP. FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. Gastroenterology. 137: 1403-14. PMID 19560465 DOI: 10.1053/j.gastro.2009.06.049  1
2009 Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Molecular and Cellular Biology. 29: 4417-30. PMID 19506018 DOI: 10.1128/MCB.01622-08  1
2009 Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 459: 55-60. PMID 19424149 DOI: 10.1038/nature07925  1
2009 Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, et al. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 7022-7. PMID 19369208 DOI: 10.1073/pnas.0811785106  1
2009 Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nature Immunology. 10: 504-13. PMID 19363483 DOI: 10.1038/ni.1729  1
2009 van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, ... ... DePinho RA, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics. 41: 521-3. PMID 19330029 DOI: 10.1038/ng.349  1
2009 Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nature Genetics. 41: 544-52. PMID 19282848 DOI: 10.1038/ng.356  1
2009 Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle (Georgetown, Tex.). 8: 1003-6. PMID 19270523  1
2009 Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology. 10: 176-84. PMID 19136962 DOI: 10.1038/ni.1689  1
2009 Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ. Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. Cancer Research. 69: 300-9. PMID 19118015 DOI: 10.1158/0008-5472.CAN-08-2145  1
2009 Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X. Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biological Psychiatry. 65: 150-9. PMID 18823877 DOI: 10.1016/j.biopsych.2008.08.005  1
2008 Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, ... ... dePinho RA, et al. Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harbor Symposia On Quantitative Biology. 73: 427-37. PMID 19150964 DOI: 10.1101/sqb.2008.73.047  1
2008 Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proceedings of the National Academy of Sciences of the United States of America. 105: 19384-9. PMID 19052232 DOI: 10.1073/pnas.0810584105  1
2008 Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, ... ... DePinho RA, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 19372-7. PMID 19050074 DOI: 10.1073/pnas.0809966105  1
2008 Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nature Immunology. 9: 1388-98. PMID 18978794 DOI: 10.1038/ni.1667  1
2008 Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, ... ... DePinho RA, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 455: 1129-33. PMID 18948956 DOI: 10.1038/nature07443  1
2008 Hu P, Geles KG, Paik JH, DePinho RA, Tjian R. Codependent activators direct myoblast-specific MyoD transcription. Developmental Cell. 15: 534-46. PMID 18854138 DOI: 10.1016/j.devcel.2008.08.018  1
2008 Stegh AH, Chin L, Louis DN, DePinho RA. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Cell Cycle (Georgetown, Tex.). 7: 2833-9. PMID 18769159  1
2008 Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes. 57: 2967-76. PMID 18728232 DOI: 10.2337/db08-0520  1
2008 Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes & Development. 22: 2028-33. PMID 18676808 DOI: 10.1101/gad.1668708  1
2008 Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 105: 10703-8. PMID 18669646 DOI: 10.1073/pnas.0712034105  1
2008 Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism. 8: 65-76. PMID 18590693 DOI: 10.1016/j.cmet.2008.06.006  1
2008 Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, ... ... DePinho RA, et al. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. Plos Medicine. 5: e123. PMID 18547137 DOI: 10.1371/journal.pmed.0050123  1
2008 Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, et al. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biology. 9: R93. PMID 18522751 DOI: 10.1186/gb-2008-9-6-r93  1
2008 Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nature Immunology. 9: 623-31. PMID 18488031 DOI: 10.1038/ni.1616  1
2008 Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. Plos Medicine. 5: e85. PMID 18416599 DOI: 10.1371/journal.pmed.0050085  1
2008 Aghi M, Visted T, Depinho RA, Chiocca EA. Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16. Oncogene. 27: 4249-54. PMID 18345032 DOI: 10.1038/onc.2008.53  1
2008 David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, Depinho RA. Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation. Proceedings of the National Academy of Sciences of the United States of America. 105: 4168-72. PMID 18332431 DOI: 10.1073/pnas.0710285105  1
2008 Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nature Genetics. 40: 455-9. PMID 18311138 DOI: 10.1038/ng.98  1
2008 Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis. 29: 747-53. PMID 18283039 DOI: 10.1093/carcin/bgn050  1
2008 de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes & Development. 22: 449-62. PMID 18258752 DOI: 10.1101/gad.1606508  1
2008 Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Molecular and Cellular Biology. 28: 2414-25. PMID 18227155 DOI: 10.1128/MCB.01621-07  1
2008 Mahoney JE, Sahin E, Jaskelioff M, Chin L, DePinho RA, Protopopov AI. Quantification of telomere length by FISH and laser scanning cytometry Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6859. DOI: 10.1117/12.763858  1
2007 O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, ... DePinho RA, et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. The Journal of Experimental Medicine. 204: 3059-66. PMID 18070937 DOI: 10.1084/jem.20071637  1
2007 Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee Eh, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, Kim H. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Research. 67: 11133-40. PMID 18056437 DOI: 10.1158/0008-5472.CAN-07-1342  1
2007 Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Research. 67: 10736-43. PMID 18006816 DOI: 10.1158/0008-5472.CAN-07-2742  1
2007 Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & Development. 21: 2683-710. PMID 17974913 DOI: 10.1101/gad.1596707  1
2007 Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (New York, N.Y.). 318: 287-90. PMID 17872411 DOI: 10.1126/science.1142946  1
2007 Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metabolism. 6: 208-16. PMID 17767907 DOI: 10.1016/j.cmet.2007.08.006  1
2007 Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. The Journal of Clinical Investigation. 117: 2477-85. PMID 17717603 DOI: 10.1172/JCI32054  1
2007 Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nature Reviews. Molecular Cell Biology. 8: 703-13. PMID 17717515 DOI: 10.1038/nrm2241  1
2007 Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proceedings of the National Academy of Sciences of the United States of America. 104: 10968-73. PMID 17576930 DOI: 10.1073/pnas.0611638104  1
2007 Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, ... ... DePinho RA, et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 447: 966-71. PMID 17515920 DOI: 10.1038/nature05886  1
2007 Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, ... ... DePinho RA, et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell. 11: 349-60. PMID 17418411 DOI: 10.1016/j.ccr.2007.02.015  1
2007 Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 3931-6. PMID 17360455 DOI: 10.1073/pnas.0700093104  1
2007 Podar K, Raab MS, Tonon G, Sattler M, Barilà D, Zhang J, Tai YT, Yasui H, Raje N, DePinho RA, Hideshima T, Chauhan D, Anderson KC. Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Research. 67: 1680-8. PMID 17308109 DOI: 10.1158/0008-5472.CAN-06-1863  1
2007 Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 53: 503-17. PMID 17296553 DOI: 10.1016/j.neuron.2007.01.009  1
2007 Yang D, McCrann DJ, Nguyen H, St Hilaire C, DePinho RA, Jones MR, Ravid K. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 6: 257-60. PMID 17291294 DOI: 10.1111/j.1474-9726.2007.00274.x  1
2007 Chu GC, Kimmelman AC, Hezel AF, DePinho RA. Stromal biology of pancreatic cancer. Journal of Cellular Biochemistry. 101: 887-907. PMID 17266048 DOI: 10.1002/jcb.21209  1
2007 Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 128: 325-39. PMID 17254970 DOI: 10.1016/j.cell.2007.01.003  1
2007 Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, ... DePinho RA, et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 128: 309-23. PMID 17254969 DOI: 10.1016/j.cell.2006.12.029  1
2007 Sharpless NE, DePinho RA. Cancer biology: gone but not forgotten. Nature. 445: 606-7. PMID 17251931 DOI: 10.1038/nature05567  1
2007 Li H, Liang J, Castrillon DH, DePinho RA, Olson EN, Liu ZP. FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription. Molecular and Cellular Biology. 27: 2676-86. PMID 17242183 DOI: 10.1128/MCB.01748-06  1
2007 Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes & Development. 21: 98-111. PMID 17210792 DOI: 10.1101/gad.1480007  1
2007 Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Molecular and Cellular Biology. 27: 2253-65. PMID 17145779 DOI: 10.1128/MCB.01354-06  1
2007 Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA. Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene. 26: 2815-21. PMID 17072335 DOI: 10.1038/sj.onc.1210099  1
2006 Farazi PA, DePinho RA. The genetic and environmental basis of hepatocellular carcinoma. Discovery Medicine. 6: 182-6. PMID 17234139  1
2006 Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes & Development. 20: 3130-46. PMID 17114584 DOI: 10.1101/gad.1478706  1
2006 Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Research. 66: 11502-13. PMID 17114236 DOI: 10.1158/0008-5472.CAN-06-2072  1
2006 Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, et al. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Research. 66: 10815-23. PMID 17090523 DOI: 10.1158/0008-5472.CAN-06-1408  1
2006 Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 443: 421-6. PMID 16957735 DOI: 10.1038/nature05159  1
2006 Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nature Reviews. Cancer. 6: 674-87. PMID 16929323 DOI: 10.1038/nrc1934  1
2006 Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Reviews. Drug Discovery. 5: 741-54. PMID 16915232 DOI: 10.1038/nrd2110  1
2006 Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB. PCAF modulates PTEN activity. The Journal of Biological Chemistry. 281: 26562-8. PMID 16829519 DOI: 10.1074/jbc.M605391200  1
2006 Farazi PA, Zeisberg M, Glickman J, Zhang Y, Kalluri R, DePinho RA. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Research. 66: 6622-7. PMID 16818635 DOI: 10.1158/0008-5472.CAN-05-4609  1
2006 Dickie R, Bachoo RM, Rupnick MA, Dallabrida SM, Deloid GM, Lai J, Depinho RA, Rogers RA. Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy. Microvascular Research. 72: 20-6. PMID 16806289 DOI: 10.1016/j.mvr.2006.05.003  1
2006 David G, Dannenberg JH, Simpson N, Finnerty PM, Miao L, Turner GM, Ding Z, Carrasco R, Depinho RA. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. Oncogene. 25: 7354-60. PMID 16767157 DOI: 10.1038/sj.onc.1209734  1
2006 Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Development. 20: 1218-49. PMID 16702400 DOI: 10.1101/gad.1415606  1
2006 Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, ... Depinho RA, et al. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 9: 379-90. PMID 16697958 DOI: 10.1016/j.ccr.2006.03.028  1
2006 Farazi PA, Glickman J, Horner J, Depinho RA. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Research. 66: 4766-73. PMID 16651430 DOI: 10.1158/0008-5472.CAN-05-4608  1
2006 Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research. 66: 4368-77. PMID 16618762 DOI: 10.1158/0008-5472.CAN-05-3617  1
2006 Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, ... ... Depinho RA, et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell. 9: 313-25. PMID 16616336 DOI: 10.1016/j.ccr.2006.03.019  1
2006 Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 103: 5947-52. PMID 16585505 DOI: 10.1073/pnas.0601273103  1
2006 Haines BB, Ryu CJ, Chang S, Protopopov A, Luch A, Kang YH, Draganov DD, Fragoso MF, Paik SG, Hong HJ, DePinho RA, Chen J. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell. 9: 109-20. PMID 16473278 DOI: 10.1016/j.ccr.2006.01.004  1
2006 Safran M, Kim WY, O'Connell F, Flippin L, Günzler V, Horner JW, Depinho RA, Kaelin WG. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America. 103: 105-10. PMID 16373502 DOI: 10.1073/pnas.0509459103  1
2006 Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, DePinho RA. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI:10.1016/j.ccr.2006.03.028) Cancer Cell. 10: 171. DOI: 10.1016/j.ccr.2006.07.012  1
2005 Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA. Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harbor Symposia On Quantitative Biology. 70: 11-24. PMID 16869734 DOI: 10.1101/sqb.2005.70.021  1
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/science.1120781  1
2005 Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes & Development. 19: 2560-70. PMID 16264192 DOI: 10.1101/gad.1321305  1
2005 Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Molecular and Cellular Biology. 25: 9491-502. PMID 16227599 DOI: 10.1128/MCB.25.21.9491-9502.2005  1
2005 Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 8: 185-95. PMID 16169464 DOI: 10.1016/j.ccr.2005.07.015  1
2005 Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. The Journal of Clinical Investigation. 115: 2382-92. PMID 16100571 DOI: 10.1172/JCI23126  1
2005 Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature. 436: 636-7. PMID 16079829 DOI: 10.1038/436636a  1
2005 Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/pnas.0504378102  1
2005 Dannenberg JH, David G, Zhong S, van der Torre J, Wong WH, Depinho RA. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes & Development. 19: 1581-95. PMID 15998811 DOI: 10.1101/gad.1286905  1
2005 Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 9625-30. PMID 15983384 DOI: 10.1073/pnas.0504126102  1
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/j.cell.2005.03.033  1
2005 Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW. Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis (New York, N.Y. : 2000). 42: 77-85. PMID 15864812 DOI: 10.1002/gene.20127  1
2005 Rünger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle (Georgetown, Tex.). 4: 643-5. PMID 15846097  1
2005 Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK. PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell Cycle (Georgetown, Tex.). 4: 540-2. PMID 15753657  1
2005 Okumura K, Zhao M, Depinho RA, Furnari FB, Cavenee WK. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 102: 2703-6. PMID 15659546 DOI: 10.1073/pnas.0409370102  1
2004 Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. Journal of the National Cancer Institute. 96: 1790-3. PMID 15572761 DOI: 10.1093/jnci/djh307  1
2004 Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes & Development. 18: 2614-26. PMID 15489287 DOI: 10.1101/gad.1244004  1
2004 Li Z, David G, Hung KW, DePinho RA, Fu AK, Ip NY. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. The Journal of Biological Chemistry. 279: 54438-44. PMID 15489224 DOI: 10.1074/jbc.M411002200  1
2004 Argilla D, Chin K, Singh M, Hodgson JG, Bosenberg M, de Solórzano CO, Lockett S, DePinho RA, Gray J, Hanahan D. Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. Cancer Cell. 6: 373-85. PMID 15488760 DOI: 10.1016/j.ccr.2004.08.032  1
2004 Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology. 24: 8437-46. PMID 15367665 DOI: 10.1128/MCB.24.19.8437-8446.2004  1
2004 Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/j.ccr.2004.06.007  1
2004 Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics. 36: 877-82. PMID 15235603 DOI: 10.1038/ng1389  1
2004 Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. Proceedings of the National Academy of Sciences of the United States of America. 101: 9067-72. PMID 15199222 DOI: 10.1073/pnas.0402932101  1
2004 Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA. Molecular diversity of astrocytes with implications for neurological disorders. Proceedings of the National Academy of Sciences of the United States of America. 101: 8384-9. PMID 15155908 DOI: 10.1073/pnas.0402140101  1
2004 Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, ... ... DePinho RA, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 5: 375-87. PMID 15093544 DOI: 10.1016/S1535-6108(04)00085-6  1
2004 Sachs Z, Sharpless NE, DePinho RA, Rosenberg N. p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. Journal of Virology. 78: 3304-11. PMID 15016851 DOI: 10.1128/JVI.78.7.3304-3311.2004  1
2004 Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 23: 379-85. PMID 14724566 DOI: 10.1038/sj.onc.1207074  1
2004 Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. The Journal of Clinical Investigation. 113: 160-8. PMID 14722605 DOI: 10.1172/JCI20761  1
2004 Attardi LD, DePinho RA. Conquering the complexity of p53. Nature Genetics. 36: 7-8. PMID 14702030 DOI: 10.1038/ng0104-7  1
2003 Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes & Development. 17: 3112-26. PMID 14681207 DOI: 10.1101/gad.1158703  1
2003 David G, Turner GM, Yao Y, Protopopov A, DePinho RA. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes & Development. 17: 2396-405. PMID 14522945 DOI: 10.1101/gad.1109403  1
2003 D'Amico M, Wu K, Di Vizio D, Reutens AT, Stahl M, Fu M, Albanese C, Russell RG, Muller WJ, White M, Negassa A, Lee HW, DePinho RA, Pestell RG. The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Research. 63: 3395-402. PMID 12810676  1
2003 DePinho RA, Wong KK. The age of cancer: telomeres, checkpoints, and longevity. The Journal of Clinical Investigation. 111: S9-14. PMID 12688272  1
2003 Gibson SL, Dai CY, Lee HW, DePinho RA, Gee MS, Lee WM, Furth EE, Brensinger C, Enders GH. Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Research. 63: 742-6. PMID 12591718  1
2003 Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421: 643-8. PMID 12540856 DOI: 10.1038/nature01385  0.32
2003 Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development. 17: 88-100. PMID 12514102 DOI: 10.1101/gad.1029903  1
2002 Chang S, DePinho RA. Telomerase extracurricular activities. Proceedings of the National Academy of Sciences of the United States of America. 99: 12520-2. PMID 12271146 DOI: 10.1073/pnas.212514699  1
2002 Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419: 162-7. PMID 12226664 DOI: 10.1038/nature01045  1
2002 O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, DePinho RA. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell. 2: 149-55. PMID 12204535 DOI: 10.1016/S1535-6108(02)00094-6  1
2002 Zhang Z, Wang Y, Herzog CR, Liu G, Lee HW, DePinho RA, You M. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene. 21: 5960-6. PMID 12185599 DOI: 10.1038/sj.onc.1205725  1
2002 Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 110: 9-12. PMID 12150992 DOI: 10.1016/S0092-8674(02)00818-8  1
2002 Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, DePinho RA, Levy DE. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 17: 63-72. PMID 12150892 DOI: 10.1016/S1074-7613(02)00336-9  1
2002 Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 1: 269-77. PMID 12086863 DOI: 10.1016/S1535-6108(02)00046-6  1
2002 Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8191-6. PMID 12034875 DOI: 10.1073/pnas.112515399  1
2002 Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA. p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Research. 62: 2761-5. PMID 12019151  1
2002 Sviderskaya EV, Hill SP, Evans-Whipp TJ, Chin L, Orlow SJ, Easty DJ, Cheong SC, Beach D, DePinho RA, Bennett DC. p16(Ink4a) in melanocyte senescence and differentiation. Journal of the National Cancer Institute. 94: 446-54. PMID 11904317  1
2002 You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 1455-60. PMID 11818530 DOI: 10.1073/pnas.022632099  1
2001 Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7  1
2001 Yang J, Luan J, Yu Y, Li C, DePinho RA, Chin L, Richmond A. Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Cancer Research. 61: 8150-7. PMID 11719444  0.4
2001 Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413: 86-91. PMID 11544531 DOI: 10.1038/35092592  1
2001 Hemann MT, Rudolph KL, Strong MA, DePinho RA, Chin L, Greider CW. Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Molecular Biology of the Cell. 12: 2023-30. PMID 11452000  1
2001 Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Current Biology : Cb. 11: 962-6. PMID 11448772 DOI: 10.1016/S0960-9822(01)00267-6  1
2001 Chang S, Khoo C, DePinho RA. Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse. Seminars in Cancer Biology. 11: 227-39. PMID 11407947 DOI: 10.1006/scbi.2000.0374  1
2001 Bardeesy N, Sharpless NE, DePinho RA, Merlino G. The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. Seminars in Cancer Biology. 11: 201-18. PMID 11407945 DOI: 10.1006/scbi.2000.0371  1
2001 Kucherlapati R, DePinho RA. Cancer. Telomerase meets its mismatch. Nature. 411: 647-8. PMID 11395749 DOI: 10.1038/35079715  1
2001 Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. Malignant glioma: genetics and biology of a grave matter. Genes & Development. 15: 1311-33. PMID 11390353 DOI: 10.1101/gad.891601  1
2001 Rudolph KL, Millard M, Bosenberg MW, DePinho RA. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genetics. 28: 155-9. PMID 11381263 DOI: 10.1038/88871  1
2001 Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 4455-60. PMID 11274364 DOI: 10.1073/pnas.081061398  1
2001 Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR, DePinho RA. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 3381-6. PMID 11248087 DOI: 10.1073/pnas.051629198  0.4
2001 Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Molecular and Cellular Biology. 21: 2144-53. PMID 11238948 DOI: 10.1128/MCB.21.6.2144-2153.2001  0.4
2001 de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 14: 45-55. PMID 11163229 DOI: 10.1016/S1074-7613(01)00088-7  1
2001 Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nature Cell Biology. 3: 1-7. PMID 11146619 DOI: 10.1038/35050500  1
2000 Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 65: 395-403. PMID 12760055  1
2000 Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ. Tetracycline-inducible system for photoreceptor-specific gene expression. Investigative Ophthalmology & Visual Science. 41: 4281-7. PMID 11095627  1
2000 Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics. 26: 85-8. PMID 10973255 DOI: 10.1038/79232  1
2000 O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes & Development. 14: 2185-91. PMID 10970882 DOI: 10.1101/gad.827200  1
2000 Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell. 102: 407-10. PMID 10966103  1
2000 Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406: 641-5. PMID 10949306 DOI: 10.1038/35020592  1
2000 Artandi SE, DePinho RA. Mice without telomerase: what can they teach us about human cancer? Nature Medicine. 6: 852-5. PMID 10932211 DOI: 10.1038/78595  1
2000 Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell. 5: 993-1002. PMID 10911993  1
2000 Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes & Development. 14: 1390-9. PMID 10837031  1
2000 Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proceedings of the National Academy of Sciences of the United States of America. 97: 6630-3. PMID 10823907 DOI: 10.1073/pnas.110152897  1
2000 Bardeesy N, Wong KK, DePinho RA, Chin L. Animal models of melanoma: recent advances and future prospects. Advances in Cancer Research. 79: 123-56. PMID 10818679  0.4
2000 Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 404: 897-900. PMID 10786799 DOI: 10.1038/35009138  0.32
2000 Chin L, DePinho RA. Flipping the oncogene switch: illumination of tumor maintenance and regression. Trends in Genetics : Tig. 16: 147-50. PMID 10729826  0.4
2000 Artandi SE, DePinho RA. A critical role for telomeres in suppressing and facilitating carcinogenesis. Current Opinion in Genetics & Development. 10: 39-46. PMID 10679392 DOI: 10.1016/S0959-437X(99)00047-7  1
2000 Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science (New York, N.Y.). 287: 1253-8. PMID 10678830 DOI: 10.1126/science.287.5456.1253  1
2000 O'Hagan RC, Schreiber-Agus N, Chen K, David G, Engelman JA, Schwab R, Alland L, Thomson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nature Genetics. 24: 113-9. PMID 10655054 DOI: 10.1038/72761  1
2000 Shen-Li H, O'Hagan RC, Hou H, Horner JW, Lee HW, DePinho RA. Essential role for Max in early embryonic growth and development. Genes & Development. 14: 17-22. PMID 10640271  1
1999 Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature. 400: 468-72. PMID 10440378 DOI: 10.1038/22788  1
1999 Ghiani CA, Yuan X, Eisen AM, Knutson PL, DePinho RA, McBain CJ, Gallo V. Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5380-92. PMID 10377348  1
1999 Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97: 527-38. PMID 10338216 DOI: 10.1016/S0092-8674(00)80762-X  1
1999 Greenberg RA, Chin L, Femino A, Lee KH, Gottlieb GJ, Singer RH, Greider CW, DePinho RA. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97: 515-25. PMID 10338215 DOI: 10.1016/S0092-8674(00)80761-8  1
1999 FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Oncogene. 18: 2489-98. PMID 10229200 DOI: 10.1038/sj.onc.1202611  1
1999 Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, et al. Telomere-dependent senescence. Nature Biotechnology. 17: 313-4. PMID 10207859 DOI: 10.1038/7827  1
1999 Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96: 701-12. PMID 10089885  1
1999 de Lange T, DePinho RA. Unlimited mileage from telomerase? Science (New York, N.Y.). 283: 947-9. PMID 10075559 DOI: 10.1126/science.283.5404.947  1
1999 Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Current Opinion in Genetics & Development. 9: 22-30. PMID 10072356 DOI: 10.1016/S0959-437X(99)80004-5  1
1999 Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 18: 1219-26. PMID 10022128 DOI: 10.1038/sj.onc.1202669  1
1999 Ghiani CA, Eisen AM, Yuan X, DePinho RA, McBain CJ, Gallo V. Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors. Development (Cambridge, England). 126: 1077-90. PMID 9927607  1
1999 Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 397: 164-8. PMID 9923679 DOI: 10.1038/16476  1
1999 Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA. Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Molecular and Cellular Biology. 19: 353-63. PMID 9858559  1
1998 Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & Development. 12: 3675-85. PMID 9851974  1
1998 Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes & Development. 12: 3467-81. PMID 9832500  0.4
1998 Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N. p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proceedings of the National Academy of Sciences of the United States of America. 95: 13194-9. PMID 9789064 DOI: 10.1073/pnas.95.22.13194  1
1998 Chin L, Pomerantz J, DePinho RA. The INK4a/ARF tumor suppressor: one gene--two products--two pathways. Trends in Biochemical Sciences. 23: 291-6. PMID 9757829  0.4
1998 Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 16: 1723-30. PMID 9582020 DOI: 10.1038/sj.onc.1201933  0.4
1998 Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature. 392: 569-74. PMID 9560153 DOI: 10.1038/33345  1
1998 Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell. 92: 713-23. PMID 9529248 DOI: 10.1016/S0092-8674(00)81400-2  1
1997 Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91: 25-34. PMID 9335332 DOI: 10.1016/S0092-8674(01)80006-4  1
1996 Hatton KS, Mahon K, Chin L, Chiu FC, Lee HW, Peng D, Morgenbesser SD, Horner J, DePinho RA. Expression and activity of L-Myc in normal mouse development. Molecular and Cellular Biology. 16: 1794-804. PMID 8657155  1
1995 Chin L, Schreiber-Agus N, Pellicer I, Chen K, Lee HW, Dudast M, Cordon-Cardo C, DePinho RA. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 92: 8488-92. PMID 7667316 DOI: 10.1073/pnas.92.18.8488  1
1991 DePinho RA, Schreiber-Agus N, Alt FW. myc family oncogenes in the development of normal and neoplastic cells. Advances in Cancer Research. 57: 1-46. PMID 1950701  0.32
1988 Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042  0.32
1987 DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939  0.32
1986 DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190  1
1986 Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 319: 73-7. PMID 3510398 DOI: 10.1038/319073a0  1
1986 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 322: 179-81. PMID 3487737 DOI: 10.1038/322179a0  0.32
1986 Scharff MD, DePinho RA, Behar S, Beychok C, Shin SU, French D. The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. Cellular Immunology. 99: 29-37. PMID 3093101 DOI: 10.1016/0008-8749(86)90212-1  1
1986 Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433  0.32
1986 DePinho RA, Feldman LB, Scharff MD. Tailor-made monoclonal antibodies. Annals of Internal Medicine. 104: 225-33. PMID 3080934  1
1986 Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778  1
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