H. Robert Horvitz - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
ALS
Website:
http://web.mit.edu/biology/www/facultyareas/facresearch/horvitz.shtml

250 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cohn J, Dwivedi V, Valperga G, Zarate N, de Bono M, Horvitz HR, Pierce JT. Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene in a Living Neuron Pair in . G3 (Bethesda, Md.). PMID 31519744 DOI: 10.1534/g3.119.400654  0.32
2018 Burton NO, Dwivedi VK, Burkhart KB, Kaplan REW, Baugh LR, Horvitz HR. Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response. Nature Communications. 9: 5152. PMID 30514845 DOI: 10.1038/s41467-018-07640-w  0.68
2018 Pender CL, Horvitz HR. Hypoxia-inducible factor cell non-autonomously regulates stress responses and behavior via a nuclear receptor. Elife. 7. PMID 30010540 DOI: 10.7554/eLife.36828  0.44
2018 Engert CG, Droste R, van Oudenaarden A, Horvitz HR. A C. elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility. Plos Genetics. 14: e1007295. PMID 29702639 DOI: 10.1371/journal.pgen.1007295  0.44
2018 Van Bael S, Watteyne J, Boonen K, De Haes W, Menschaert G, Ringstad N, Horvitz HR, Schoofs L, Husson S, Temmerman L. Mass Spectrometric Evidence for Neuropeptide-Amidating Enzymes in. The Journal of Biological Chemistry. PMID 29487130 DOI: 10.1074/jbc.RA117.000731  1
2017 Driscoll K, Stanfield GM, Droste R, Horvitz HR. Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. PMID 28760991 DOI: 10.1073/pnas.1705084114  1
2017 Luo S, Horvitz HR. The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage. Current Biology : Cb. 27: 661-672. PMID 28238659 DOI: 10.1016/j.cub.2017.01.056  0.56
2017 Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nature Cell Biology. 19: 252-257. PMID 28166192 DOI: 10.1038/ncb3470  0.68
2016 Paquin N, Murata Y, Froehlich A, Omura DT, Ailion M, Pender CL, Constantine-Paton M, Horvitz HR. The Conserved VPS-50 Protein Functions in Dense-Core Vesicle Maturation and Acidification and Controls Animal Behavior. Current Biology : Cb. 26: 862-71. PMID 26948874 DOI: 10.1016/j.cub.2016.01.049  0.44
2015 Zinovyeva AY, Veksler-Lublinsky I, Vashisht AA, Wohlschlegel JA, Ambros VR. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Proceedings of the National Academy of Sciences of the United States of America. 112: E5271-80. PMID 26351692 DOI: 10.1073/pnas.1506576112  0.52
2015 Bhatla N, Droste R, Sando SR, Huang A, Horvitz HR. Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans. Current Biology : Cb. 25: 2075-89. PMID 26212880 DOI: 10.1016/j.cub.2015.06.052  0.44
2015 Ma DK, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR. Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell. 161: 1152-63. PMID 25981666 DOI: 10.1016/j.cell.2015.04.026  0.44
2015 Bhatla N, Horvitz HR. Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons. Neuron. 85: 804-18. PMID 25640076 DOI: 10.1016/j.neuron.2014.12.061  0.44
2015 Bhatla N, Droste R, Sando SR, Huang A, Horvitz HR. Distinct neural circuits control rhythm inhibition and spitting by the myogenic pharynx of C. elegans Current Biology. 25: 2075-2089. DOI: 10.1016/j.cub.2015.06.052  1
2014 Hirose T, Horvitz HR. The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans. Plos Genetics. 10: e1004512. PMID 25101958 DOI: 10.1371/journal.pgen.1004512  0.12
2014 Rawson RL, Yam L, Weimer RM, Bend EG, Hartwieg E, Horvitz HR, Clark SG, Jorgensen EM. Axons degenerate in the absence of mitochondria in C. elegans. Current Biology : Cb. 24: 760-5. PMID 24631238 DOI: 10.1016/j.cub.2014.02.025  1
2014 de la Cruz IP, Ma L, Horvitz HR. The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9. Plos Genetics. 10: e1004175. PMID 24586202 DOI: 10.1371/journal.pgen.1004175  0.68
2013 Hirose T, Horvitz HR. An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature. 500: 354-8. PMID 23851392 DOI: 10.1038/nature12329  1
2013 Suzuki J, Denning DP, Imanishi E, Horvitz HR, Nagata S. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science (New York, N.Y.). 341: 403-6. PMID 23845944 DOI: 10.1126/science.1236758  1
2013 Ma DK, Rothe M, Zheng S, Bhatla N, Pender CL, Menzel R, Horvitz HR. Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans. Science (New York, N.Y.). 341: 554-8. PMID 23811225 DOI: 10.1126/science.1235753  0.44
2013 Denning DP, Hatch V, Horvitz HR. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. Plos Genetics. 9: e1003341. PMID 23505386 DOI: 10.1371/journal.pgen.1003341  1
2012 Anderson C, Zhou S, Sawin E, Horvitz HR, Hurwitz ME. SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function. Plos Genetics. 8: e1003115. PMID 23271977 DOI: 10.1371/journal.pgen.1003115  0.36
2012 Emtage L, Aziz-Zaman S, Padovan-Merhar O, Horvitz HR, Fang-Yen C, Ringstad N. IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16285-95. PMID 23152612 DOI: 10.1523/JNEUROSCI.2667-12.2012  1
2012 Gürel G, Gustafson MA, Pepper JS, Horvitz HR, Koelle MR. Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans. Genetics. 192: 1359-71. PMID 23023001 DOI: 10.1534/genetics.112.142125  0.92
2012 Ma L, Gao X, Luo J, Huang L, Teng Y, Horvitz HR. The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. Plos Genetics. 8: e1002827. PMID 22829783 DOI: 10.1371/journal.pgen.1002827  0.68
2012 Denning DP, Hatch V, Horvitz HR. Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature. 488: 226-30. PMID 22801495 DOI: 10.1038/nature11240  0.24
2012 Ma DK, Vozdek R, Bhatla N, Horvitz HR. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron. 73: 925-40. PMID 22405203 DOI: 10.1016/j.neuron.2011.12.037  0.44
2011 Saffer AM, Kim DH, van Oudenaarden A, Horvitz HR. The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF. Plos Genetics. 7: e1002418. PMID 22242000 DOI: 10.1371/journal.pgen.1002418  0.68
2011 Nakano S, Stillman B, Horvitz HR. Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans. Cell. 147: 1525-36. PMID 22177093 DOI: 10.1016/j.cell.2011.11.053  0.96
2011 Ma L, Tan Z, Teng Y, Hoersch S, Horvitz HR. In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans. Rna (New York, N.Y.). 17: 2201-11. PMID 22033331 DOI: 10.1261/rna.027458.111  0.68
2011 Harris DT, Horvitz HR. MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. Development (Cambridge, England). 138: 4051-62. PMID 21862562 DOI: 10.1242/dev.065417  0.04
2011 Tabuchi TM, Deplancke B, Osato N, Zhu LJ, Barrasa MI, Harrison MM, Horvitz HR, Walhout AJ, Hagstrom KA. Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. Plos Genetics. 7: e1002074. PMID 21589891 DOI: 10.1371/journal.pgen.1002074  0.92
2011 Galvin BD, Denning DP, Horvitz HR. SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 108: 1998-2003. PMID 21245325 DOI: 10.1073/pnas.1018805108  1
2011 Davison EM, Saffer AM, Huang LS, DeModena J, Sternberg PW, Horvitz HR. The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics. 187: 803-15. PMID 21196525 DOI: 10.1534/genetics.110.124487  1
2011 Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM, Horvitz HR, Sternberg PW, Ringstad N. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 108: 254-9. PMID 21173231 DOI: 10.1073/pnas.1017354108  1
2010 Nakano S, Ellis RE, Horvitz HR. Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans. Development (Cambridge, England). 137: 4017-27. PMID 21041366 DOI: 10.1242/dev.058834  1
2010 Hirose T, Galvin BD, Horvitz HR. Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 107: 15479-84. PMID 20713707 DOI: 10.1073/pnas.1010023107  1
2010 Alvarez-Saavedra E, Horvitz HR. Many families of C. elegans microRNAs are not essential for development or viability. Current Biology : Cb. 20: 367-73. PMID 20096582 DOI: 10.1016/j.cub.2009.12.051  0.52
2009 Jospin M, Qi YB, Stawicki TM, Boulin T, Schuske KR, Horvitz HR, Bessereau JL, Jorgensen EM, Jin Y. A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. Plos Biology. 7: e1000265. PMID 20027209 DOI: 10.1371/journal.pbio.1000265  0.76
2009 Ma L, Horvitz HR. Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo. Plos Genetics. 5: e1000708. PMID 19893607 DOI: 10.1371/journal.pgen.1000708  0.68
2009 Ringstad N, Abe N, Horvitz HR. Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science (New York, N.Y.). 325: 96-100. PMID 19574391 DOI: 10.1126/science.1169243  1
2009 Hurwitz ME, Vanderzalm PJ, Bloom L, Goldman J, Garriga G, Horvitz HR. Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. Plos Biology. 7: e99. PMID 19402756 DOI: 10.1371/journal.pbio.1000099  0.72
2009 Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, ... ... Horvitz HR, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (New York, N.Y.). 323: 1205-8. PMID 19251627 DOI: 10.1126/science.1166066  1
2009 Vanderzalm PJ, Pandey A, Hurwitz ME, Bloom L, Horvitz HR, Garriga G. C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development. Development (Cambridge, England). 136: 1201-10. PMID 19244282 DOI: 10.1242/dev.026666  0.72
2009 Yu H, Seah A, Herman MA, Ferguson EL, Horvitz HR, Sternberg PW. Wnt and EGF pathways act together to induce C. elegans male hook development. Developmental Biology. 327: 419-32. PMID 19154732 DOI: 10.1016/j.ydbio.2008.12.023  1
2008 Ringstad N, Horvitz HR. FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Nature Neuroscience. 11: 1168-76. PMID 18806786 DOI: 10.1038/nn.2186  1
2008 Andersen EC, Saffer AM, Horvitz HR. Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates. Genetics. 179: 2001-12. PMID 18689876 DOI: 10.1534/genetics.108.092197  1
2008 Galvin BD, Kim S, Horvitz HR. Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33. Genetics. 179: 403-17. PMID 18458102 DOI: 10.1534/genetics.108.087221  0.4
2008 Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz HR, Schier AF, Dulac C. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 57: 41-55. PMID 18184563 DOI: 10.1016/j.neuron.2007.11.018  0.52
2007 Miska EA, Alvarez-Saavedra E, Abbott AL, Lau NC, Hellman AB, McGonagle SM, Bartel DP, Ambros VR, Horvitz HR. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. Plos Genetics. 3: e215. PMID 18085825 DOI: 10.1371/journal.pgen.0030215  0.52
2007 Schwartz HT, Horvitz HR. The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9. Genes & Development. 21: 3181-94. PMID 18056428 DOI: 10.1101/gad.1607007  0.48
2007 Eimer S, Gottschalk A, Hengartner M, Horvitz HR, Richmond J, Schafer WR, Bessereau JL. Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. The Embo Journal. 26: 4313-23. PMID 17853888 DOI: 10.1038/sj.emboj.7601858  0.64
2007 Andersen EC, Horvitz HR. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Development (Cambridge, England). 134: 2991-9. PMID 17634190 DOI: 10.1242/dev.009373  1
2007 Harrison MM, Lu X, Horvitz HR. LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics. 176: 255-71. PMID 17409073 DOI: 10.1534/genetics.106.069633  1
2007 Reddien PW, Andersen EC, Huang MC, Horvitz HR. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans. Genetics. 175: 1719-33. PMID 17237514 DOI: 10.1534/genetics.106.068148  1
2006 Harrison MM, Ceol CJ, Lu X, Horvitz HR. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proceedings of the National Academy of Sciences of the United States of America. 103: 16782-7. PMID 17075059 DOI: 10.1073/pnas.0608461103  1
2006 Andersen EC, Lu X, Horvitz HR. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Development (Cambridge, England). 133: 2695-704. PMID 16774993 DOI: 10.1242/dev.02444  1
2006 Su CW, Tharin S, Jin Y, Wightman B, Spector M, Meili D, Tsung N, Rhiner C, Bourikas D, Stoeckli E, Garriga G, Horvitz HR, Hengartner MO. The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. Journal of Biology. 5: 9. PMID 16725058 DOI: 10.1186/jbiol39  0.76
2006 Ceol CJ, Stegmeier F, Harrison MM, Horvitz HR. Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development. Genetics. 173: 709-26. PMID 16624904 DOI: 10.1534/genetics.106.056465  0.92
2006 Morita M, Al-Chalabi A, Andersen PM, Hosler B, Sapp P, Englund E, Mitchell JE, Habgood JJ, de Belleroche J, Xi J, Jongjaroenprasert W, Horvitz HR, Gunnarsson LG, Brown RH. A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia. Neurology. 66: 839-44. PMID 16421333 DOI: 10.1212/01.wnl.0000200048.53766.b4  1
2005 Abbott AL, Alvarez-Saavedra E, Miska EA, Lau NC, Bartel DP, Horvitz HR, Ambros V. The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Developmental Cell. 9: 403-14. PMID 16139228 DOI: 10.1016/j.devcel.2005.07.009  1
2005 Davison EM, Harrison MM, Walhout AJ, Vidal M, Horvitz HR. lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics. 171: 1017-31. PMID 16020796 DOI: 10.1534/genetics.104.034173  0.92
2005 Frank CA, Hawkins NC, Guenther C, Horvitz HR, Garriga G. C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions. Developmental Biology. 284: 301-10. PMID 15979607 DOI: 10.1016/j.ydbio.2005.05.026  0.72
2005 Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature. 435: 834-8. PMID 15944708 DOI: 10.1038/nature03702  0.52
2005 Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH. MicroRNA expression in zebrafish embryonic development. Science (New York, N.Y.). 309: 310-1. PMID 15919954 DOI: 10.1126/science.1114519  0.52
2005 Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR. Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron. 46: 247-60. PMID 15848803 DOI: 10.1016/j.neuron.2005.02.024  1
2004 Reddien PW, Horvitz HR. The engulfment process of programmed cell death in caenorhabditis elegans. Annual Review of Cell and Developmental Biology. 20: 193-221. PMID 15473839 DOI: 10.1146/annurev.cellbio.20.022003.114619  1
2004 Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology. 5: R68. PMID 15345052 DOI: 10.1186/gb-2004-5-9-r68  0.52
2004 Jäger S, Schwartz HT, Horvitz HR, Conradt B. The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome. Proceedings of the National Academy of Sciences of the United States of America. 101: 12549-54. PMID 15306688 DOI: 10.1073/pnas.0405087101  0.48
2004 Ceol CJ, Horvitz HR. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Developmental Cell. 6: 563-76. PMID 15068795 DOI: 10.1016/S1534-5807(04)00065-6  1
2004 Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell. 116: S53-6, 1 p following. PMID 15055582  1
2003 de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR. sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9133-45. PMID 14534247  0.4
2003 Hwang HY, Olson SK, Esko JD, Horvitz HR. Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature. 423: 439-43. PMID 12761549 DOI: 10.1038/nature01634  0.36
2003 Thomas JH, Ceol CJ, Schwartz HT, Horvitz HR. New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics. 164: 135-51. PMID 12750327  0.88
2003 Hwang HY, Olson SK, Brown JR, Esko JD, Horvitz HR. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. The Journal of Biological Chemistry. 278: 11735-8. PMID 12584198 DOI: 10.1074/jbc.C200518200  0.36
2002 Hwang HY, Horvitz HR. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Proceedings of the National Academy of Sciences of the United States of America. 99: 14224-9. PMID 12391315 DOI: 10.1073/pnas.172522499  0.36
2002 Hwang HY, Horvitz HR. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 99: 14218-23. PMID 12391314 DOI: 10.1073/pnas.172522199  0.36
2002 Tzur YB, Hersh BM, Horvitz HR, Gruenbaum Y. Fate of the nuclear lamina during Caenorhabditis elegans apoptosis. Journal of Structural Biology. 137: 146-53. PMID 12064941 DOI: 10.1006/jsbi.2002.4452  0.76
2002 Cameron S, Clark SG, McDermott JB, Aamodt E, Horvitz HR. PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans. Development (Cambridge, England). 129: 1763-74. PMID 11923211  1
2002 Hersh BM, Hartwieg E, Horvitz HR. The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types. Proceedings of the National Academy of Sciences of the United States of America. 99: 4355-60. PMID 11904372 DOI: 10.1073/pnas.062065399  0.76
2001 Starr DA, Hermann GJ, Malone CJ, Fixsen W, Priess JR, Horvitz HR, Han M. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development (Cambridge, England). 128: 5039-50. PMID 11748140  1
2001 Lundquist EA, Reddien PW, Hartwieg E, Horvitz HR, Bargmann CI. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development (Cambridge, England). 128: 4475-88. PMID 11714673  0.76
2001 Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Developmental Cell. 1: 477-89. PMID 11703939 DOI: 10.1016/S1534-5807(01)00058-2  1
2001 Ranganathan R, Sawin ER, Trent C, Horvitz HR. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5871-84. PMID 11487610  1
2001 Ceol CJ, Horvitz HR. dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Molecular Cell. 7: 461-73. PMID 11463372 DOI: 10.1016/S1097-2765(01)00194-0  1
2001 Reddien PW, Cameron S, Horvitz HR. Phagocytosis promotes programmed cell death in C. elegans. Nature. 412: 198-202. PMID 11449278 DOI: 10.1038/35084096  1
2001 Berninsone P, Hwang HY, Zemtseva I, Horvitz HR, Hirschberg CB. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose. Proceedings of the National Academy of Sciences of the United States of America. 98: 3738-43. PMID 11259660 DOI: 10.1073/pnas.061593098  1
2001 Zhou Z, Hartwieg E, Horvitz HR. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell. 104: 43-56. PMID 11163239 DOI: 10.1016/S0092-8674(01)00190-8  1
2000 Ranganathan R, Cannon SC, Horvitz HR. MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Nature. 408: 470-5. PMID 11100728 DOI: 10.1038/35044083  1
2000 Hosler BA, Siddique T, Sapp PC, Sailor W, Huang MC, Hossain A, Daube JR, Nance M, Fan C, Kaplan J, Hung WY, McKenna-Yasek D, Haines JL, Pericak-Vance MA, Horvitz HR, et al. Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. Jama. 284: 1664-9. PMID 11015796  1
2000 Speliotes EK, Uren A, Vaux D, Horvitz HR. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Molecular Cell. 6: 211-23. PMID 10983970  1
2000 Beitel GJ, Lambie EJ, Horvitz HR. The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Gene. 254: 253-63. PMID 10974557 DOI: 10.1016/S0378-1119(00)00296-1  1
2000 Harris TW, Hartwieg E, Horvitz HR, Jorgensen EM. Mutations in synaptojanin disrupt synaptic vesicle recycling. The Journal of Cell Biology. 150: 589-600. PMID 10931870 DOI: 10.1083/jcb.150.3.589  1
2000 Sawin ER, Ranganathan R, Horvitz HR. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron. 26: 619-31. PMID 10896158  1
2000 Stanfield GM, Horvitz HR. The ced-8 gene controls the timing of programmed cell deaths in C. elegans. Molecular Cell. 5: 423-33. PMID 10882128  1
2000 Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular Cell. 5: 659-69. PMID 10882102  1
2000 Wu YC, Stanfield GM, Horvitz HR. NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. Genes & Development. 14: 536-48. PMID 10716942  1
2000 Reddien PW, Horvitz HR. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nature Cell Biology. 2: 131-6. PMID 10707082 DOI: 10.1038/35004000  1
2000 Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403: 901-6. PMID 10706289 DOI: 10.1038/35002607  1
2000 Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz HR. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science (New York, N.Y.). 287: 1485-9. PMID 10688797 DOI: 10.1126/science.287.5457.1485  1
2000 Lorson MA, Horvitz HR, van den Heuvel S. LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans. The Journal of Cell Biology. 148: 73-86. PMID 10629219 DOI: 10.1083/jcb.148.1.73  1
1999 Shaham S, Reddien PW, Davies B, Horvitz HR. Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics. 153: 1655-71. PMID 10581274  1
1999 Newman AP, Acton GZ, Hartwieg E, Horvitz HR, Sternberg PW. The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells. Development (Cambridge, England). 126: 5319-26. PMID 10556057  1
1999 Metzstein MM, Horvitz HR. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Molecular Cell. 4: 309-19. PMID 10518212 DOI: 10.1016/S1097-2765(00)80333-0  1
1999 Conradt B, Horvitz HR. The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell. 98: 317-27. PMID 10458607 DOI: 10.1016/S0092-8674(00)81961-3  1
1999 Eastman C, Horvitz HR, Jin Y. Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6225-34. PMID 10414952  1
1999 Thomas JH, Horvitz HR. The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway. Development (Cambridge, England). 126: 3449-59. PMID 10393123  1
1999 Malone CJ, Fixsen WD, Horvitz HR, Han M. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development (Cambridge, England). 126: 3171-81. PMID 10375507  1
1999 Horvitz HR. Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Research. 59: 1701s-1706s. PMID 10197583  1
1999 Herman T, Horvitz HR. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. Proceedings of the National Academy of Sciences of the United States of America. 96: 974-9. PMID 9927678  0.24
1999 Herman T, Hartwieg E, Horvitz HR. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Proceedings of the National Academy of Sciences of the United States of America. 96: 968-73. PMID 9927677  1
1999 Gumienny TL, Lambie E, Hartwieg E, Horvitz HR, Hengartner MO. Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development (Cambridge, England). 126: 1011-22. PMID 9927601  1
1999 Jin Y, Jorgensen E, Hartwieg E, Horvitz HR. The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 539-48. PMID 9880574  1
1999 Lee RY, Sawin ER, Chalfie M, Horvitz HR, Avery L. EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 159-67. PMID 9870947  1
1998 Hosler BA, Sapp PC, Berger R, O'Neill G, Bejaoui K, Hamida MB, Hentati F, Chin W, McKenna-Yasek D, Haines JL, Patterson D, Horvitz HR, Brown RH, Day CB. Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33. Neurogenetics. 2: 34-42. PMID 9933298 DOI: 10.1007/s100480050049  1
1998 Lu X, Horvitz HR. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell. 95: 981-91. PMID 9875852 DOI: 10.1016/S0092-8674(00)81722-5  1
1998 Metzstein MM, Stanfield GM, Horvitz HR. Genetics of programmed cell death in C. elegans: past, present and future. Trends in Genetics : Tig. 14: 410-6. PMID 9820030 DOI: 10.1016/S0168-9525(98)01573-X  1
1998 Gonzales-Rosales F, Walsh D, Burkons L, Burkons J, Horvitz HR. Chronic bleeding secondary to an unresectable duodenal adenocarcinoma controlled with sucralfate and famotidine. Palliative Medicine. 12: 205-6. PMID 9743840 DOI: 10.1191/026921698674325884  1
1998 Jacobs D, Beitel GJ, Clark SG, Horvitz HR, Kornfeld K. Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. Genetics. 149: 1809-22. PMID 9691039  1
1998 Wu YC, Horvitz HR. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. Cell. 93: 951-60. PMID 9635425 DOI: 10.1016/S0092-8674(00)81201-5  1
1998 Conradt B, Horvitz HR. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell. 93: 519-29. PMID 9604928 DOI: 10.1016/S0092-8674(00)81182-4  1
1998 Kokel M, Borland CZ, DeLong L, Horvitz HR, Stern MJ. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes & Development. 12: 1425-37. PMID 9585503  1
1998 Aoki M, Lin CL, Rothstein JD, Geller BA, Hosler BA, Munsat TL, Horvitz HR, Brown RH. Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. Annals of Neurology. 43: 645-53. PMID 9585360 DOI: 10.1002/ana.410430514  1
1998 Wu YC, Horvitz HR. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature. 392: 501-4. PMID 9548255 DOI: 10.1038/33163  1
1998 Hodgkin J, Horvitz HR, Jasny BR, Kimble J. C. elegans: Sequence to biology Science. 282: 2011. DOI: 10.1126/science.282.5396.2011  1
1997 Herman T, Horvitz HR. Mutations that perturb vulval invagination in C. elegans. Cold Spring Harbor Symposia On Quantitative Biology. 62: 353-9. PMID 9598369  1
1997 Tax FE, Thomas JH, Ferguson EL, Horvitz HR. Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans. Genetics. 147: 1675-95. PMID 9409830  1
1997 Xue D, Horvitz HR. Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature. 390: 305-8. PMID 9384385 DOI: 10.1038/36889  1
1997 Barkett M, Xue D, Horvitz HR, Gilmore TD. Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. The Journal of Biological Chemistry. 272: 29419-22. PMID 9367996 DOI: 10.1074/jbc.272.47.29419  1
1997 Nonet ML, Staunton JE, Kilgard MP, Fergestad T, Hartwieg E, Horvitz HR, Jorgensen EM, Meyer BJ. Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8061-73. PMID 9334382  1
1997 Lee RY, Lobel L, Hengartner M, Horvitz HR, Avery L. Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. The Embo Journal. 16: 6066-76. PMID 9321386 DOI: 10.1093/emboj/16.20.6066  1
1997 Bloom L, Horvitz HR. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proceedings of the National Academy of Sciences of the United States of America. 94: 3414-9. PMID 9096408 DOI: 10.1073/pnas.94.7.3414  1
1997 Cudkowicz ME, McKenna-Yasek D, Sapp PE, Chin W, Geller B, Hayden DL, Schoenfeld DA, Hosler BA, Horvitz HR, Brown RH. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Annals of Neurology. 41: 210-21. PMID 9029070 DOI: 10.1002/ana.410410212  1
1996 Hosler BA, Nicholson GA, Sapp PC, Chin W, Orrell RW, de Belleroche JS, Esteban J, Hayward LJ, Mckenna-Yasek D, Yeung L, Cherryson AK, Dench JE, Wilton SD, Laing NG, Horvitz HR, et al. Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. Neuromuscular Disorders : Nmd. 6: 361-6. PMID 8938700 DOI: 10.1016/0960-8966(96)00353-7  1
1996 Sawa H, Lobel L, Horvitz HR. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes & Development. 10: 2189-97. PMID 8804313  1
1996 Labouesse M, Hartwieg E, Horvitz HR. The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates. Development (Cambridge, England). 122: 2579-88. PMID 8787733  0.76
1996 Basson M, Horvitz HR. The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. Genes & Development. 10: 1953-65. PMID 8756352  1
1996 Shaham S, Horvitz HR. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell. 86: 201-8. PMID 8706125 DOI: 10.1016/S0092-8674(00)80092-6  1
1996 Metzstein MM, Hengartner MO, Tsung N, Ellis RE, Horvitz HR. Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature. 382: 545-7. PMID 8700229 DOI: 10.1038/382545a0  1
1996 Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. Journal of Neurochemistry. 67: 46-57. PMID 8667025  1
1996 Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes & Development. 10: 1073-83. PMID 8654923  1
1996 Shaham S, Horvitz HR. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes & Development. 10: 578-91. PMID 8598288  1
1996 Koelle MR, Horvitz HR. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell. 84: 115-25. PMID 8548815 DOI: 10.1016/S0092-8674(00)80998-8  1
1995 Beitel GJ, Tuck S, Greenwald I, Horvitz HR. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes & Development. 9: 3149-62. PMID 8543158  1
1995 Kornfeld K, Hom DB, Horvitz HR. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell. 83: 903-13. PMID 8521514 DOI: 10.1016/0092-8674(95)90206-6  1
1995 Kornfeld K, Guan KL, Horvitz HR. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Development. 9: 756-68. PMID 7729691  1
1995 Bowling AC, Barkowski EE, McKenna-Yasek D, Sapp P, Horvitz HR, Beal MF, Brown RH. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 64: 2366-9. PMID 7722523  1
1995 Xue D, Horvitz HR. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature. 377: 248-51. PMID 7675111 DOI: 10.1038/377248a0  0.84
1995 Chisholm AD, Horvitz HR. Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3. Nature. 377: 52-5. PMID 7659159 DOI: 10.1038/377052a0  1
1995 DeVore DL, Horvitz HR, Stern MJ. An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell. 83: 611-20. PMID 7585964 DOI: 10.1016/0092-8674(95)90101-9  1
1995 Herman MA, Vassilieva LL, Horvitz HR, Shaw JE, Herman RK. The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell. 83: 101-10. PMID 7553861 DOI: 10.1016/0092-8674(95)90238-4  1
1995 Sapp PC, Rosen DR, Hosler BA, Esteban J, McKenna-Yasek D, O'Regan JP, Horvitz HR, Brown RH. Identification of three novel mutations in the gene for Cu/Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis. Neuromuscular Disorders : Nmd. 5: 353-7. PMID 7496169 DOI: 10.1016/0960-8966(95)00007-A  1
1995 Jorgensen EM, Hartwieg E, Schuske K, Nonet ML, Jin Y, Horvitz HR. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans. Nature. 378: 196-9. PMID 7477324 DOI: 10.1038/378196a0  1
1994 Lackner MR, Kornfeld K, Miller LM, Horvitz HR, Kim SK. A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes & Development. 8: 160-73. PMID 8299936  1
1994 Herman MA, Horvitz HR. The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions. Development (Cambridge, England). 120: 1035-47. PMID 8026318  0.92
1994 Jin Y, Hoskins R, Horvitz HR. Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature. 372: 780-3. PMID 7997265 DOI: 10.1038/372780a0  1
1994 Clark SG, Lu X, Horvitz HR. The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics. 137: 987-97. PMID 7982579  1
1994 Gregor P, Gaston SM, Yang X, O'Regan JP, Rosen DR, Tanzi RE, Patterson D, Haines JL, Horvitz HR, Uhl GR. Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Human Genetics. 94: 565-70. PMID 7959697 DOI: 10.1007/BF00211029  1
1994 Labouesse M, Sookhareea S, Horvitz HR. The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor. Development (Cambridge, England). 120: 2359-68. PMID 7956818  1
1994 Esteban J, Rosen DR, Bowling AC, Sapp P, McKenna-Yasek D, O'Regan JP, Beal MF, Horvitz HR, Brown RH. Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis. Human Molecular Genetics. 3: 997-8. PMID 7951252  1
1994 Rosen DR, Bowling AC, Patterson D, Usdin TB, Sapp P, Mezey E, McKenna-Yasek D, O'Regan J, Rahmani Z, Ferrante RJ. A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis. Human Molecular Genetics. 3: 981-7. PMID 7951249  1
1994 Hengartner MO, Horvitz HR. Programmed cell death in Caenorhabditis elegans. Current Opinion in Genetics & Development. 4: 581-6. PMID 7950327 DOI: 10.1016/0959-437X(94)90076-F  1
1994 Rosen DR, Sapp P, O'Regan J, McKenna-Yasek D, Schlumpf KS, Haines JL, Gusella JF, Horvitz HR, Brown RH. Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers. American Journal of Medical Genetics. 51: 61-9. PMID 7913294 DOI: 10.1002/ajmg.1320510114  1
1994 Hengartner MO, Horvitz HR. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature. 369: 318-20. PMID 7910376 DOI: 10.1038/369318a0  1
1994 Hengartner MO, Horvitz HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell. 76: 665-76. PMID 7907274 DOI: 10.1016/0092-8674(94)90506-1  1
1994 Hengartner MO, Horvitz HR. The ins and outs of programmed cell death during C. elegans development. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 345: 243-6. PMID 7846120 DOI: 10.1098/rstb.1994.0100  1
1994 Horvitz HR, Shaham S, Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symposia On Quantitative Biology. 59: 377-85. PMID 7587090  1
1994 Rosen DR, Sapp P, McKenna-Yasek D, Horvitz HR, Brown RH. A molecular basis of familial ALS Clinical Chemistry. 40: 638-639.  1
1993 Kaplan JM, Horvitz HR. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 90: 2227-31. PMID 8460126  1
1993 Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362: 59-62. PMID 8446170 DOI: 10.1038/362059a0  1
1993 Bargmann CI, Hartwieg E, Horvitz HR. Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell. 74: 515-27. PMID 8348618 DOI: 10.1016/0092-8674(93)80053-H  1
1993 McIntire SL, Jorgensen E, Kaplan J, Horvitz HR. The GABAergic nervous system of Caenorhabditis elegans. Nature. 364: 337-41. PMID 8332191 DOI: 10.1038/364337a0  0.96
1993 McIntire SL, Jorgensen E, Horvitz HR. Genes required for GABA function in Caenorhabditis elegans. Nature. 364: 334-7. PMID 8332190 DOI: 10.1038/364334a0  1
1993 Avery L, Bargmann CI, Horvitz HR. The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics. 134: 455-64. PMID 8325482  1
1993 Garriga G, Desai C, Horvitz HR. Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans. Development (Cambridge, England). 117: 1071-87. PMID 8325236  0.76
1993 Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 75: 641-52. PMID 8242740 DOI: 10.1016/0092-8674(93)90485-9  1
1993 Garriga G, Guenther C, Horvitz HR. Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins. Genes & Development. 7: 2097-109. PMID 8224840  1
1993 Levin JZ, Horvitz HR. Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9. Genetics. 135: 53-70. PMID 8224828  1
1993 Clark SG, Chisholm AD, Horvitz HR. Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39. Cell. 74: 43-55. PMID 8101475 DOI: 10.1016/0092-8674(93)90293-Y  1
1992 McIntire SL, Garriga G, White J, Jacobson D, Horvitz HR. Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron. 8: 307-22. PMID 1739461 DOI: 10.1016/0896-6273(92)90297-Q  0.96
1992 Horvitz HR, Herskowitz I. Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell. 68: 237-55. PMID 1733500  1
1992 Hengartner MO, Ellis RE, Horvitz HR. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 356: 494-9. PMID 1560823 DOI: 10.1038/356494a0  1
1992 Clark SG, Stern MJ, Horvitz HR. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature. 356: 340-4. PMID 1372395 DOI: 10.1038/356340a0  1
1992 Clark SG, Stern MJ, Horvitz HR. Genes involved in two Caenorhabditis elegans cell-signaling pathways. Cold Spring Harbor Symposia On Quantitative Biology. 57: 363-73. PMID 1339671  1
1992 Levin JZ, Horvitz HR. The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction. The Journal of Cell Biology. 117: 143-55. PMID 1313436  1
1992 Rosen DR, Sapp PC, O'Regan J, Horvitz HR, Donaldson DH, Nussbaum C, Gusella JF, Haines JL, Pestka S, Jung V. Dinucleotide repeat polymorphisms (D21S223 and D21S224) at 21q22.1. Human Molecular Genetics. 1: 547. PMID 1307256  1
1992 Donaldson DH, Rosen DR, O'Regan J, Sapp PC, Horvitz HR, Gusella JF, Haines JL, Pestka S, Jung V, Nusbaum C. Two independent dinucleotide repeat polymorphisms at the D21S235 locus (21q22.1). Human Molecular Genetics. 1: 651. PMID 1301176 DOI: 10.1093/hmg/1.8.651  1
1992 Yuan J, Horvitz HR. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development (Cambridge, England). 116: 309-20. PMID 1286611  1
1991 Bargmann CI, Horvitz HR. Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science (New York, N.Y.). 251: 1243-6. PMID 2006412  1
1991 Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 129: 79-94. PMID 1936965  1
1991 Li PM, Reichert J, Freyd G, Horvitz HR, Walsh CT. The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain. Proceedings of the National Academy of Sciences of the United States of America. 88: 9210-3. PMID 1924383  1
1991 Brown RH, Horvitz HR, Rouleau GA, McKenna-Yasek D, Beard C, Sapp P, Haines JL, Gusella JF, Figlewicz DA. Gene linkage in familial amyotrophic lateral sclerosis: a progress report. Advances in Neurology. 56: 215-26. PMID 1853758  1
1991 Yuan JY, Finney M, Tsung N, Horvitz HR. Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure. Proceedings of the National Academy of Sciences of the United States of America. 88: 3334-8. PMID 1849651  1
1991 Stern MJ, Horvitz HR. A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Development (Cambridge, England). 113: 797-803. PMID 1821851  1
1991 Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Annual Review of Cell Biology. 7: 663-98. PMID 1809356 DOI: 10.1146/annurev.cb.07.110191.003311  1
1991 Ellis RE, Horvitz HR. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development (Cambridge, England). 112: 591-603. PMID 1794327  1
1991 Sternberg PW, Horvitz HR. Signal transduction during C. elegans vulval induction. Trends in Genetics : Tig. 7: 366-71. PMID 1668188 DOI: 10.1016/0168-9525(91)90257-Q  1
1991 Bargmann CI, Horvitz HR. Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron. 7: 729-42. PMID 1660283 DOI: 10.1016/0896-6273(91)90276-6  1
1991 Horvitz HR, Sternberg PW. Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva. Nature. 351: 535-41. PMID 1646401 DOI: 10.1038/351535a0  1
1990 Thomas JH, Stern MJ, Horvitz HR. Cell interactions coordinate the development of the C. elegans egg-laying system. Cell. 62: 1041-52. PMID 2401010 DOI: 10.1016/0092-8674(90)90382-O  1
1990 Ruvkun G, Gilbert W, Horvitz HR. Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Research. 18: 809-15. PMID 2315039 DOI: 10.1093/nar/18.4.809  1
1990 Yuan JY, Horvitz HR. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Developmental Biology. 138: 33-41. PMID 2307287 DOI: 10.1016/0012-1606(90)90174-H  1
1990 Horvitz HR, Sulston JE. "Joy of the worm". Genetics. 126: 287-92. PMID 2245910  0.96
1990 Avery L, Horvitz HR. Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. The Journal of Experimental Zoology. 253: 263-70. PMID 2181052 DOI: 10.1002/jez.1402530305  1
1990 Kim SK, Horvitz HR. The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates. Genes & Development. 4: 357-71. PMID 2159938  0.44
1990 Bargmann CI, Thomas JH, Horvitz HR. Chemosensory cell function in the behavior and development of Caenorhabditis elegans. Cold Spring Harbor Symposia On Quantitative Biology. 55: 529-38. PMID 2132836  1
1990 Beitel GJ, Clark SG, Horvitz HR. Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature. 348: 503-9. PMID 2123303 DOI: 10.1038/348503a0  1
1990 Freyd G, Kim SK, Horvitz HR. Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature. 344: 876-9. PMID 1970421 DOI: 10.1038/344876a0  1
1989 Ferguson EL, Horvitz HR. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics. 123: 109-21. PMID 2806880  1
1989 Desai C, Horvitz HR. Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics. 121: 703-21. PMID 2721931  1
1989 Avery L, Horvitz HR. Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans. Neuron. 3: 473-85. PMID 2642006  0.36
1989 Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR. Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 121: 501-16. PMID 2565854  1
1989 Sternberg PW, Horvitz HR. The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell. 58: 679-93. PMID 2548732 DOI: 10.1016/0092-8674(89)90103-7  1
1989 Ferguson EL, Horvitz HR. The multivulva phenotype of certain C. elegans mutants results from defects in two functionally redundant pathways Trends in Genetics. 5: 363.  1
1988 Trent C, Wood WB, Horvitz HR. A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans. Genetics. 120: 145-57. PMID 3220248  1
1988 Desai C, Garriga G, McIntire SL, Horvitz HR. A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature. 336: 638-46. PMID 3200316 DOI: 10.1038/336638a0  1
1988 Sternberg PW, Horvitz HR. lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions. Developmental Biology. 130: 67-73. PMID 3181641 DOI: 10.1016/0012-1606(88)90414-9  1
1988 Horvitz HR. Genetic control of Caenorhabditis elegans cell lineage. Harvey Lectures. 84: 65-77. PMID 3079281  1
1988 Finney M, Ruvkun G, Horvitz HR. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell. 55: 757-69. PMID 2903797 DOI: 10.1016/0092-8674(88)90132-8  1
1987 Avery L, Horvitz HR. A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. Cell. 51: 1071-8. PMID 3690660 DOI: 10.1016/0092-8674(87)90593-9  1
1987 Ambros V, Horvitz HR. The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes & Development. 1: 398-414. PMID 3678829  1
1987 Ferguson EL, Sternberg PW, Horvitz HR. A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans. Nature. 326: 259-67. PMID 2881214 DOI: 10.1038/326259a0  1
1986 Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell. 44: 817-29. PMID 3955651 DOI: 10.1016/0092-8674(86)90004-8  1
1986 Sternberg PW, Horvitz HR. Pattern formation during vulval development in C. elegans. Cell. 44: 761-72. PMID 3753901 DOI: 10.1016/0092-8674(86)90842-1  1
1986 Park EC, Horvitz HR. C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle. Genetics. 113: 853-67. PMID 3744029  1
1986 Park EC, Horvitz HR. Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans. Genetics. 113: 821-52. PMID 3744028  1
1986 Greenwald I, Horvitz HR. A visible allele of the muscle gene sup-10X of C. elegans. Genetics. 113: 63-72. PMID 3710144  1
1985 Ferguson EL, Horvitz HR. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 110: 17-72. PMID 3996896  1
1984 Ambros V, Horvitz HR. Heterochronic mutants of the nematode Caenorhabditis elegans. Science (New York, N.Y.). 226: 409-16. PMID 6494891  1
1984 Sternberg PW, Horvitz HR. The genetic control of cell lineage during nematode development. Annual Review of Genetics. 18: 489-524. PMID 6397125 DOI: 10.1146/annurev.ge.18.120184.002421  1
1983 Trent C, Tsuing N, Horvitz HR. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 104: 619-47. PMID 11813735  1
1983 Greenwald IS, Sternberg PW, Horvitz HR. The lin-12 locus specifies cell fates in Caenorhabditis elegans. Cell. 34: 435-44. PMID 6616618 DOI: 10.1016/0092-8674(83)90377-X  1
1983 Horvitz HR, Sternberg PW, Greenwald IS, Fixsen W, Ellis HM. Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. Cold Spring Harbor Symposia On Quantitative Biology. 48: 453-63. PMID 6586368  1
1982 Horvitz HR, Sternberg PW. Nematode postembryonic cell lineages. Journal of Nematology. 14: 240-8. PMID 19295705  1
1982 Greenwald IS, Horvitz HR. Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans. Genetics. 101: 211-25. PMID 7173602  1
1982 Sternberg PW, Horvitz HR. Postembryonic nongonadal cell lineages of the nematode Panagrellus redivivus: description and comparison with those of Caenorhabditis elegans. Developmental Biology. 93: 181-205. PMID 7128930 DOI: 10.1016/0012-1606(82)90251-2  1
1982 White JG, Horvitz HR, Sulston JE. Neurone differentiation in cell lineage mutants of Caenorhabditis elegans. Nature. 297: 584-7. PMID 7088142 DOI: 10.1038/297584a0  1
1982 Horvitz HR, Chalfie M, Trent C, Sulston JE, Evans PD. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science (New York, N.Y.). 216: 1012-4. PMID 6805073 DOI: 10.1126/science.6805073  1
1981 Sternberg PW, Horvitz HR. Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage. Developmental Biology. 88: 147-66. PMID 7286441 DOI: 10.1016/0012-1606(81)90226-8  1
1981 Chalfie M, Horvitz HR, Sulston JE. Mutations that lead to reiterations in the cell lineages of C. elegans. Cell. 24: 59-69. PMID 7237544 DOI: 10.1016/0092-8674(81)90501-8  1
1981 Sulston JE, Horvitz HR. Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Developmental Biology. 82: 41-55. PMID 7014288 DOI: 10.1016/0012-1606(81)90427-9  1
1980 Horvitz HR, Sulston JE. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 96: 435-54. PMID 7262539  1
1980 Greenwald IS, Horvitz HR. unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. Genetics. 96: 147-64. PMID 6894129  1
1979 Hodgkin J, Horvitz HR, Brenner S. Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS. Genetics. 91: 67-94. PMID 17248881  1
1979 Horvitz HR, Brenner S, Hodgkin J, Herman RK. A uniform genetic nomenclature for the nematode Caenorhabditis elegans. Molecular & General Genetics : Mgg. 175: 129-33. PMID 292825 DOI: 10.1007/BF00425528  1
1977 Sulston JE, Horvitz HR. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Developmental Biology. 56: 110-56. PMID 838129 DOI: 10.1016/0012-1606(77)90158-0  1
1975 Horvitz HR. Studies of mutations in T4 control genes 33 and 55. Genetics. 79: 349-60. PMID 1126625  1
1974 Horvitz HR. Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase. Journal of Molecular Biology. 90: 739-50. PMID 4615179 DOI: 10.1016/0022-2836(74)90537-3  1
1974 Horvitz HR. Control by bacteriophage T4 of two sequential phosphorylations of the alpha subunit of Escherichia coli RNA polymerase. Journal of Molecular Biology. 90: 727-38. PMID 4615178 DOI: 10.1016/0022-2836(74)90536-1  1
1973 Horvitz HR. Polypeptide bound to the host RNA polymerase is specified by T4 control gene 33. Nature: New Biology. 244: 137-40. PMID 4579464  1
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