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Michael Downey - Publications

Affiliations: 
2014 University of Ottawa, Ottawa, ON, Canada 
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 McCarthy L, Abramchuk I, Wafy G, Denoncourt A, Lavallée-Adam M, Downey M. Ddp1 Cooperates with Ppx1 to Counter a Stress Response Initiated by Nonvacuolar Polyphosphate. Mbio. e0039022. PMID 35862758 DOI: 10.1128/mbio.00390-22  0.315
2022 Pereira C, Arroyo-Martinez GA, Guo MZ, Downey MS, Kelly ER, Grive KJ, Mahadevaiah SK, Sims JR, Faca VM, Tsai C, Schiltz CJ, Wit N, Jacobs H, Clark NL, Freire R, et al. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. Elife. 11. PMID 35133274 DOI: 10.7554/eLife.68677  0.328
2020 Downey M. Non-histone protein acetylation by the evolutionarily conserved GCN5 and PCAF acetyltransferases. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194608. PMID 32711095 DOI: 10.1016/J.Bbagrm.2020.194608  0.383
2019 McCarthy L, Bentley-DeSousa A, Denoncourt A, Tseng YC, Gabriel M, Downey M. Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast. Febs Letters. PMID 31466120 DOI: 10.1002/1873-3468.13588  0.358
2019 Sebaa R, Johnson J, Pileggi C, Norgren M, Xuan J, Sai Y, Tong Q, Krystkowiak I, Bondy-Chorney E, Davey NE, Krogan N, Downey M, Harper ME. SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1. Molecular Metabolism. PMID 31060926 DOI: 10.1016/J.Molmet.2019.04.008  0.302
2019 Rössl A, Denoncourt A, Lin MS, Downey M. A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs. The Journal of Biological Chemistry. PMID 30804216 DOI: 10.1074/Jbc.Ra118.006051  0.365
2019 Downey M. A stringent analysis of polyphosphate dynamics in . Journal of Bacteriology. PMID 30782636 DOI: 10.1128/Jb.00070-19  0.306
2018 Bentley-DeSousa A, Downey M. From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation. Current Genetics. PMID 29881919 DOI: 10.1007/S00294-018-0854-4  0.397
2018 Bondy-Chorney E, Denoncourt A, Sai Y, Downey M. Non-histone targets of KAT2A and KAT2B implicated in cancer biology. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 29671337 DOI: 10.1139/Bcb-2017-0297  0.348
2018 Bentley-DeSousa A, Holinier C, Moteshareie H, Tseng YC, Kajjo S, Nwosu C, Amodeo GF, Bondy-Chorney E, Sai Y, Rudner A, Golshani A, Davey NE, Downey M. A Screen for Candidate Targets of Lysine Polyphosphorylation Uncovers a Conserved Network Implicated in Ribosome Biogenesis. Cell Reports. 22: 3427-3439. PMID 29590613 DOI: 10.1016/J.Celrep.2018.02.104  0.702
2018 Costa EMD, Armaos G, Beaudry A, Richer C, Caron M, St-Onge P, Johnson J, Krogan N, Sai Y, Downey M, Sinnett D, McGraw S, Raynal NJ. Abstract 1381: Targeting histone acetyltransferases to reprogram high C-MYC expressing cancers Cancer Research. 78: 1381-1381. DOI: 10.1158/1538-7445.Am2018-1381  0.335
2016 Rössl A, Bentley-DeSousa A, Tseng YC, Nwosu C, Downey M. Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases. Genetics. PMID 27527516 DOI: 10.1534/Genetics.116.193524  0.463
2015 Downey M, Baetz K. Building a KATalogue of acetyllysine targeting and function. Briefings in Functional Genomics. PMID 26512033 DOI: 10.1093/Bfgp/Elv045  0.391
2015 Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Molecular & Cellular Proteomics : McP. 14: 162-76. PMID 25381059 DOI: 10.1074/Mcp.M114.043141  0.665
2014 Edenberg ER, Downey M, Toczyski D. Polymerase stalling during replication, transcription and translation. Current Biology : Cb. 24: R445-52. PMID 24845677 DOI: 10.1016/J.Cub.2014.03.060  0.655
2013 Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Current Biology : Cb. 23: 1638-48. PMID 23973296 DOI: 10.1016/J.Cub.2013.06.050  0.688
2010 Downey M, Edenberg ER, Toczyski DP. Repair scaffolding reaches new heights at blocked replication forks. Molecular Cell. 39: 162-4. PMID 20670884 DOI: 10.1016/J.Molcel.2010.07.007  0.651
2008 Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, et al. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell. 32: 259-75. PMID 18951093 DOI: 10.1016/J.Molcel.2008.10.002  0.598
2008 Addinall SG, Downey M, Yu M, Zubko MK, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D. A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae. Genetics. 180: 2251-66. PMID 18845848 DOI: 10.1534/Genetics.108.092577  0.654
2006 Downey M, Durocher D. gammaH2AX as a checkpoint maintenance signal. Cell Cycle (Georgetown, Tex.). 5: 1376-81. PMID 16855385 DOI: 10.4161/Cc.5.13.2899  0.639
2006 Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 124: 1155-68. PMID 16564010 DOI: 10.1016/J.Cell.2005.12.044  0.636
2006 Downey M, Durocher D. Chromatin and DNA repair: the benefits of relaxation. Nature Cell Biology. 8: 9-10. PMID 16389287 DOI: 10.1038/Ncb0106-9  0.669
2006 Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 439: 497-501. PMID 16299494 DOI: 10.1038/Nature04384  0.684
2006 Keogh M, Kim J, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, et al. Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery Nature. 441: 120-120. DOI: 10.1038/Nature04772  0.616
2005 McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. The Journal of Biological Chemistry. 280: 42227-36. PMID 16159877 DOI: 10.1074/Jbc.M507410200  0.393
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