Marcia C. Haigis - Publications

Affiliations: 
2002 Department of Biochemistry University of Wisconsin, Madison, Madison, WI 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, ... ... Haigis MC, et al. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Molecular Cell. 63: 1006-1020. PMID 27635760 DOI: 10.1016/j.molcel.2016.08.014  1
2016 Vyas S, Zaganjor E, Haigis MC. Mitochondria and Cancer. Cell. 166: 555-66. PMID 27471965 DOI: 10.1016/j.cell.2016.07.002  1
2015 Jeong SM, Haigis MC. Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Molecules and Cells. 38: 750-8. PMID 26420294 DOI: 10.14348/molcells.2015.0167  1
2015 German NJ, Haigis MC. Sirtuins and the Metabolic Hurdles in Cancer. Current Biology : Cb. 25: R569-83. PMID 26126285 DOI: 10.1016/j.cub.2015.05.012  1
2015 Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC. Nuclear respiratory factor 2 induces SIRT3 expression. Aging Cell. PMID 26109058 DOI: 10.1111/acel.12360  1
2015 Gonzalez Herrera KN, Lee J, Haigis MC. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. Critical Reviews in Biochemistry and Molecular Biology. 1-14. PMID 25898275 DOI: 10.3109/10409238.2015.1031879  1
2015 Ron-Harel N, Sharpe AH, Haigis MC. Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 61: 131-8. PMID 25402204 DOI: 10.1159/000362502  1
2015 Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 34: 2115-24. PMID 24909164 DOI: 10.1038/onc.2014.124  1
2014 LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature Cell Biology. 16: 992-1003, 1-15. PMID 25241037 DOI: 10.1038/ncb3039  1
2014 Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 10574-9. PMID 25002509 DOI: 10.1073/pnas.1409844111  1
2014 Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, ... ... Haigis MC, et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: 10299-304. PMID 24982195 DOI: 10.1073/pnas.1404399111  1
2014 Satterstrom FK, Haigis MC. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods in Enzymology. 543: 141-63. PMID 24924131 DOI: 10.1016/B978-0-12-801329-8.00007-6  1
2014 Jeong SM, Lee A, Lee J, Haigis MC. SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. The Journal of Biological Chemistry. 289: 4135-44. PMID 24368766 DOI: 10.1074/jbc.M113.525949  1
2013 Bause AS, Matsui MS, Haigis MC. The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation. The Journal of Biological Chemistry. 288: 36484-91. PMID 24194516 DOI: 10.1074/jbc.M113.472324  1
2013 Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC. SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Molecular and Cellular Biology. 33: 4552-61. PMID 24043310 DOI: 10.1128/MCB.00087-13  1
2013 Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, ... ... Haigis MC, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Molecular Cell. 50: 686-98. PMID 23746352 DOI: 10.1016/j.molcel.2013.05.012  1
2013 Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Molecular Cancer Research : McR. 11: 1072-7. PMID 23723075 DOI: 10.1158/1541-7786.MCR-13-0040-T  1
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/j.cell.2013.04.023  1
2013 Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, ... ... Haigis MC, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23: 450-63. PMID 23562301 DOI: 10.1016/j.ccr.2013.02.024  1
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/nature12040  1
2013 Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Molecular Cell. 50: 172-84. PMID 23499007 DOI: 10.1016/j.molcel.2013.02.014  1
2013 Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cellular and Molecular Life Sciences : Cmls. 70: 2015-29. PMID 23283301 DOI: 10.1007/s00018-012-1244-6  1
2013 Bause AS, Haigis MC. SIRT3 regulation of mitochondrial oxidative stress. Experimental Gerontology. 48: 634-9. PMID 22964489 DOI: 10.1016/j.exger.2012.08.007  1
2012 Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R. From sirtuin biology to human diseases: an update. The Journal of Biological Chemistry. 287: 42444-52. PMID 23086954 DOI: 10.1074/jbc.R112.402768  1
2012 Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, ... Haigis MC, et al. A metabolic prosurvival role for PML in breast cancer. The Journal of Clinical Investigation. 122: 3088-100. PMID 22886304 DOI: 10.1172/JCI62129  1
2012 Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, ... Haigis MC, et al. Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93. PMID 22770219 DOI: 10.1016/j.cell.2012.05.038  1
2012 Finley LW, Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends in Molecular Medicine. 18: 516-23. PMID 22749020 DOI: 10.1016/j.molmed.2012.05.004  1
2012 Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/pnas.1201487109  1
2012 Haigis MC, Deng CX, Finley LW, Kim HS, Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Research. 72: 2468-72. PMID 22589271 DOI: 10.1158/0008-5472.CAN-11-3633  1
2012 Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 10: 515-9. PMID 22560075 DOI: 10.1016/j.stem.2012.04.002  1
2012 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/j.cell.2012.02.030  1
2012 Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proceedings of the National Academy of Sciences of the United States of America. 109: 2931-6. PMID 22308395 DOI: 10.1073/pnas.1115813109  1
2011 De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 20: 400-13. PMID 21907929 DOI: 10.1016/j.ccr.2011.08.014  1
2011 Srivastava S, Haigis MC. Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases. Current Pharmaceutical Design. 17: 3418-33. PMID 21902666 DOI: 10.2174/138161211798072526  1
2011 Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. Plos One. 6: e23295. PMID 21858060 DOI: 10.1371/journal.pone.0023295  1
2011 Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell. 19: 416-28. PMID 21397863 DOI: 10.1016/j.ccr.2011.02.014  1
2011 Haigis MC, Sinclair DA. Sirtuins in aging and age-related diseases Handbook of the Biology of Aging. 243-274. DOI: 10.1016/B978-0-12-378638-8.00011-7  1
2010 Haigis MC, Yankner BA. The aging stress response. Molecular Cell. 40: 333-44. PMID 20965426 DOI: 10.1016/j.molcel.2010.10.002  1
2010 Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends in Biochemical Sciences. 35: 669-75. PMID 20863707 DOI: 10.1016/j.tibs.2010.07.003  1
2010 Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology. 5: 253-95. PMID 20078221 DOI: 10.1146/annurev.pathol.4.110807.092250  1
2010 Lomb DJ, Laurent G, Haigis MC. Sirtuins regulate key aspects of lipid metabolism. Biochimica Et Biophysica Acta. 1804: 1652-7. PMID 19962456 DOI: 10.1016/j.bbapap.2009.11.021  1
2009 Finley LW, Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Research Reviews. 8: 173-88. PMID 19491041 DOI: 10.1016/j.arr.2009.03.003  1
2009 Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 137: 560-70. PMID 19410549 DOI: 10.1016/j.cell.2009.02.026  1
2008 Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics. 40: 600-8. PMID 18372904 DOI: 10.1038/ng.115  1
2006 Haigis MC, Guarente LP. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes & Development. 20: 2913-21. PMID 17079682 DOI: 10.1101/gad.1467506  1
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/j.cell.2006.06.057  1
2005 Dickson KA, Haigis MC, Raines RT. Ribonuclease inhibitor: structure and function. Progress in Nucleic Acid Research and Molecular Biology. 80: 349-74. PMID 16164979 DOI: 10.1016/S0079-6603(05)80009-1  1
2004 Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/BJ20041081  1
2003 Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Research. 31: 1024-32. PMID 12560499 DOI: 10.1093/nar/gkg163  1
2003 Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Journal of Cell Science. 116: 313-24. PMID 12482917 DOI: 10.1242/jcs.00214  1
2002 Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 306: 100-7. PMID 12069420 DOI: 10.1006/abio.2002.5678  1
2002 Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology and Evolution. 19: 959-63. PMID 12032252  1
2002 Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. The Journal of Biological Chemistry. 277: 11576-81. PMID 11801605 DOI: 10.1074/jbc.M112227200  1
2002 Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 124: 368-9. PMID 11792194 DOI: 10.1021/ja017283v  1
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