Year |
Citation |
Score |
2024 |
Ai Y, Meng Y, Yan B, Zhou Q, Wang X. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death. Molecular Cell. 84: 170-179. PMID 38181758 DOI: 10.1016/j.molcel.2023.11.040 |
0.344 |
|
2022 |
Guo J, Guo Z, Huang Y, Ma S, Yan B, Pan C, Jiang Z, Wang F, Zhang Z, Da Y, Wang X, Ying Z. Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2121552119. PMID 35344427 DOI: 10.1073/pnas.2121552119 |
0.488 |
|
2020 |
Ai Y, He H, Chen P, Yan B, Zhang W, Ding Z, Li D, Chen J, Ma Y, Cao Y, Zhu J, Li J, Ou J, Du S, Wang X, et al. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity. Nature Communications. 11: 3236. PMID 32591543 DOI: 10.1038/S41467-020-17052-4 |
0.396 |
|
2020 |
Barnes DE, Wang X, Frye SV, Earp HS, DeRyckere D, Barnes DK. Abstract 6388: MERTK and ROCK inhibitors mediate synergistic AML cell death and enhance therapeutic activity in combination with cytotoxic chemotherapy Cancer Research. 80: 6388-6388. DOI: 10.1158/1538-7445.Am2020-6388 |
0.353 |
|
2020 |
Yan D, Huelse J, Parker R, Tan Z, Wang X, Frye SV, Earp HS, DeRyckere D, Graham DK. Abstract 1882: MERTK drives residual tumor growth in EGFR-mutated non-small cell lung cancer cells treated with osimertinib Cancer Research. 80: 1882-1882. DOI: 10.1158/1538-7445.Am2020-1882 |
0.343 |
|
2019 |
Cao R, Li L, Ying Z, Cao Z, Ma Y, Mao X, Li J, Qi X, Zhang Z, Wang X. A small molecule protects mitochondrial integrity by inhibiting mTOR activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31653761 DOI: 10.1073/Pnas.1911246116 |
0.341 |
|
2019 |
Da C, Zhang D, Stashko M, Vasileiadi E, Parker R, Minson KA, Huey MG, Huelse JM, Hunter D, Gilbert TSK, Norris-Drouin J, Miley M, Herring LE, Graves LM, DeRyckere D, ... ... Wang X, et al. Data-driven construction of anti-tumor agents with controlled polypharmacology. Journal of the American Chemical Society. PMID 31497954 DOI: 10.1021/Jacs.9B08660 |
0.325 |
|
2019 |
Holtzhausen A, Harris W, Ubil E, Hunter DM, Zhao J, Zhang Y, Zhang D, Liu Q, Wang X, Graham DK, Frye SV, Earp HS. TAM Family Receptor kinase inhibition reverses MDSC-mediated suppression and augments anti-PD-1 therapy in melanoma. Cancer Immunology Research. PMID 31451482 DOI: 10.1158/2326-6066.Cir-19-0008 |
0.325 |
|
2019 |
Li D, Chen J, Ai Y, Gu X, Li L, Che D, Jiang Z, Li L, Chen S, Huang H, Wang J, Cai T, Cao Y, Qi X, Wang X. Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Molecular Cell. PMID 31420216 DOI: 10.1016/J.Molcel.2019.06.040 |
0.395 |
|
2019 |
Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science Signaling. 12. PMID 31311847 DOI: 10.1126/Scisignal.Aav7259 |
0.336 |
|
2019 |
Fan W, Guo J, Gao B, Zhang W, Ling L, Xu T, Pan C, Li L, Chen S, Wang H, Zhang J, Wang X. Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis. Science Signaling. 12. PMID 31138766 DOI: 10.1126/Scisignal.Aaw3423 |
0.587 |
|
2019 |
Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, et al. MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nature Communications. 10: 1515. PMID 30944303 DOI: 10.1038/S41467-019-09233-7 |
0.374 |
|
2019 |
Pan Z, Dumas EK, Lawrence C, Pate L, Longobardi S, Wang X, James JA, Kovats S, Farris AD. Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling. International Journal of Molecular Sciences. 20. PMID 30866434 DOI: 10.3390/Ijms20051167 |
0.307 |
|
2019 |
Zhang S, Su Y, Ying Z, Guo D, Pan C, Guo J, Zou Z, Wang L, Zhang Z, Jiang Z, Zhang Z, Wang X. RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30837313 DOI: 10.1073/Pnas.1819917116 |
0.6 |
|
2019 |
Gu C, Stashko MA, Puhl-Rubio A, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure/Activity Analysis. Journal of Medicinal Chemistry. PMID 30624931 DOI: 10.2210/Pdb6M8D/Pdb |
0.356 |
|
2019 |
Yan D, Huelse J, Parker R, Wang X, Frye SV, Earp HS, DeRyckere D, Graham D. Abstract 4765: MERTK is a potential therapeutic target in osimertinib-resistant non-small cell lung cancer Cancer Research. 79: 4765-4765. DOI: 10.1158/1538-7445.Sabcs18-4765 |
0.321 |
|
2019 |
Summers RJ, Minson KA, Wang X, Frye SV, Earp HS, DeRyckere D, Graham DK. Abstract A35: MERTK and BCL-2 as potential therapeutic targets in early T-precursor acute lymphoblastic leukemia Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-A35 |
0.326 |
|
2018 |
Zhao J, Zhang D, Zhang W, Stashko MA, DeRyckere D, Vasileiadi E, Parker RE, Hunter D, Liu Q, Zhang Y, Norris-Drouin JL, Li B, Drewry D, Kireev DB, Graham DK, ... ... Wang X, et al. Highly selective MERTK inhibitors achieved by a single methyl group. Journal of Medicinal Chemistry. PMID 30347155 DOI: 10.1021/Acs.Jmedchem.8B01229 |
0.309 |
|
2018 |
Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, Zhang S, Yuan T, Cao R, Jiang Z, Chen S, Wang F, Wang X. Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Molecular Cell. PMID 30344099 DOI: 10.1016/J.Molcel.2018.09.011 |
0.57 |
|
2018 |
He S, Wang X. RIP kinases as modulators of inflammation and immunity. Nature Immunology. 19: 912-922. PMID 30131615 DOI: 10.1038/S41590-018-0188-X |
0.307 |
|
2018 |
McDaniel NK, Cummings CT, Brand TM, Iida M, Hulse J, Pearson HE, Orbuch RA, Ondracek OJ, Davies KD, Gill P, Wang X, Frye SV, Earp HS, Kimple RJ, Harari PM, et al. Abstract A140: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A140 |
0.32 |
|
2017 |
Li L, Jiang X, Huang S, Ying Z, Zhang Z, Pan C, Li S, Wang X, Zhang Z. Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. Acs Medicinal Chemistry Letters. 8: 407-412. PMID 28435527 DOI: 10.1021/Acsmedchemlett.6B00489 |
0.624 |
|
2017 |
Yan B, Liu L, Huang S, Ren Y, Wang H, Yao Z, Li L, Chen S, Wang X, Zhang Z. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chemical Communications (Cambridge, England). PMID 28267172 DOI: 10.1039/C7Cc00667E |
0.326 |
|
2017 |
Yan D, Wang X, Frye SV, Earp SH, DeRyckere D, Graham DK. Abstract 1082: MerTK promotes resistance to irreversible EGFR TKIs by activation of the PI3K-AKT pathway in NSCLCs expressing wild-type EGFR Cancer Research. 77: 1082-1082. DOI: 10.1158/1538-7445.Am2017-1082 |
0.329 |
|
2016 |
Ren Y, Su Y, Sun L, He S, Meng L, Liao D, Liu X, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X, Zhang Z. Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. Journal of Medicinal Chemistry. PMID 27992216 DOI: 10.1021/Acs.Jmedchem.6B01196 |
0.338 |
|
2016 |
Jiang X, Li L, Ying Z, Pan C, Huang S, Li L, Dai M, Yan B, Li M, Jiang H, Chen S, Zhang Z, Wang X. A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway. Molecular Cell. 63: 229-39. PMID 27447985 DOI: 10.1016/J.Molcel.2016.06.016 |
0.649 |
|
2016 |
Li D, Li C, Li L, Chen S, Wang L, Li Q, Wang X, Lei X, Shen Z. Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chemical Biology. 23: 257-266. PMID 27028885 DOI: 10.1016/J.Chembiol.2015.08.018 |
0.383 |
|
2016 |
Minson KA, Huey MG, Hill AA, Perez I, Wang X, Frye S, Earp HS, DeRyckere D, Graham DK. Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Leukemia Blood. 128: 2819-2819. DOI: 10.1182/Blood.V128.22.2819.2819 |
0.352 |
|
2015 |
Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proceedings of the National Academy of Sciences of the United States of America. 112: 5017-22. PMID 25852146 DOI: 10.1073/Pnas.1505244112 |
0.395 |
|
2015 |
Graham D, DeRyckere D, Minson K, Smith C, Hill A, Huey M, Lasater E, Wang X, Shah N, Frye S, Shelton Earp H. Development of novel small molecule MerTK and Flt3 tyrosine kinase inhibitors for treatment of acute leukemia Annals of Oncology. 26: ii6. DOI: 10.1093/Annonc/Mdv082.2 |
0.367 |
|
2014 |
Yang YC, Wang XD, Huang K, Wang L, Jiang ZL, Qi YX. Temporal phosphoproteomics to investigate the mechanotransduction of vascular smooth muscle cells in response to cyclic stretch. Journal of Biomechanics. 47: 3622-9. PMID 25458152 DOI: 10.1016/J.Jbiomech.2014.10.008 |
0.317 |
|
2014 |
Sun L, Wang X. A new kind of cell suicide: mechanisms and functions of programmed necrosis. Trends in Biochemical Sciences. 39: 587-93. PMID 25455759 DOI: 10.1016/J.Tibs.2014.10.003 |
0.363 |
|
2014 |
Jiang X, Jiang H, Shen Z, Wang X. Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 111: 14782-7. PMID 25275009 DOI: 10.1073/Pnas.1417253111 |
0.417 |
|
2014 |
Wang H, Sun L, Su L, Rizo J, Liu L, Wang L, Wang F, Wang X. Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 Molecular Cell. 54: 133-146. PMID 24703947 DOI: 10.1016/J.Molcel.2014.03.003 |
0.356 |
|
2014 |
DeRyckere D, Lee-Sherick AB, Hill AA, Page L, Wang X, Frye SV, Earp HS, Graham DK. UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia Blood. 124: 998-998. DOI: 10.1182/Blood.V124.21.998.998 |
0.34 |
|
2014 |
Minson KA, Smith CC, Lee-Sherick AB, DeRyckere D, Lasater E, Hill AA, Wang X, Frye SV, Earp HS, Shah NP, Graham DK. MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia Blood. 124: 3757-3757. DOI: 10.1182/Blood.V124.21.3757.3757 |
0.35 |
|
2014 |
Earp HS, Darr D, Zimmermann A, Clark K, Sharpless NE, Bergmeier W, Zhang W, Wang X, DeRyckere D, Frye S, Graham D. Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma Cancer Research. 74: 947-947. DOI: 10.1158/1538-7445.Am2014-947 |
0.349 |
|
2014 |
Teodorovic LS, Carrico J, DeRyckere D, Zhang W, Wang X, Frye S, Eckhardt SG, Earp HS, Graham DK. Abstract 730: Efficacy of a novel small molecule MER receptor tyrosine kinase inhibitor in B-RAF wild-type and B-RAF mutant melanoma cell lines Cancer Research. 74: 730-730. DOI: 10.1158/1538-7445.Am2014-730 |
0.338 |
|
2014 |
Sherick AL, Menachof K, Hill A, Rinella S, DeRyckere D, Liu J, Wang X, Frye S, Earp HS, Graham D. Abstract 1743: A dual FLT-3 and MER tyrosine kinase small molecule inhibitor in acute myeloid leukemia cell lines and patient samples Cancer Research. 74: 1743-1743. DOI: 10.1158/1538-7445.Am2014-1743 |
0.37 |
|
2014 |
Cummings CT, Davies KD, Carrico J, DeRyckere D, Zhang W, Wang X, Frye S, Earp HS, Graham DK. Abstract 1742: Inhibition of Mer tyrosine kinase with a novel small molecule inhibitor is efficacious in pre-clinical models of non-small cell lung cancer Cancer Research. 74: 1742-1742. DOI: 10.1158/1538-7445.Am2014-1742 |
0.374 |
|
2014 |
DeRyckere DA, Hill AA, Wang X, Zhang W, Stashko MA, Sather S, Cummings C, Kireev D, Janzen WP, Frye SV, Earp HS, Graham DK. Abstract 1740: Development of a novel small molecule MER tyrosine kinase inhibitor with therapeutic activity in cell culture and mouse models of acute lymphoblastic leukemia Cancer Research. 74: 1740-1740. DOI: 10.1158/1538-7445.Am2014-1740 |
0.372 |
|
2014 |
Newton TP, Cummings CT, Kirkpatrick GD, Hinz TK, DeRyckere D, Zhang W, Wang X, Frye S, Earp HS, Heasley L, Graham DK. Abstract 1736: A novel Mer tyrosine kinase inhibitor mediates increased cell killing in combination with FGFR inhibition Cancer Research. 74: 1736-1736. DOI: 10.1158/1538-7445.Am2014-1736 |
0.369 |
|
2014 |
Wu J, Huey L, Bash RE, Cohen SM, Ewend MG, Wang X, Graham DK, Frye SV, Earp HS, Miller CR. NT-38 * MerTK AS A TARGET IN GLIOBLASTOMA Neuro-Oncology. 16: v166-v167. DOI: 10.1093/Neuonc/Nou265.36 |
0.307 |
|
2014 |
Liao D, Sun L, Liu W, He S, Wang X, Lei X. Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein Medchemcomm. 5: 333-337. DOI: 10.1039/C3Md00278K |
0.33 |
|
2014 |
Wang X, Frye S. Chapter Nineteen - Mer Receptor Tyrosine Kinase: Therapeutic Opportunities in Oncology, Virology, and Cardiovascular Indications Annual Reports in Medicinal Chemistry. 49: 301-314. DOI: 10.1016/B978-0-12-800167-7.00019-5 |
0.341 |
|
2013 |
Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, ... ... Wang X, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. Journal of Medicinal Chemistry. 56: 9693-700. PMID 24219778 DOI: 10.1021/Jm501217P |
0.333 |
|
2013 |
Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells Nature Chemical Biology. 9: 84-89. PMID 23292651 DOI: 10.1038/Nchembio.1153 |
0.4 |
|
2013 |
Lee-Sherick AB, Menachof K, Hill AA, Rinella S, Liu J, DeRyckere D, Wang X, Frye SV, Earp HS, Graham DK. UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia Blood. 122: 3849-3849. DOI: 10.1182/Blood.V122.21.3849.3849 |
0.36 |
|
2013 |
DeRyckere D, Wang X, Hill AA, Zhang W, Stashko MA, Sather S, Cummings CE, Janzen WP, Frye SV, Earp HS, Graham DK. Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia Blood. 122: 2666-2666. DOI: 10.1182/Blood.V122.21.2666.2666 |
0.339 |
|
2013 |
Christoph S, Maag S, DeRyckere D, Graham DK, Frye SV, Earp HS, Liu J, Yang C, Zhang W, Wang X, Elmaagacli AH, Beelen D. Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma Blood. 122: 1957-1957. DOI: 10.1182/Blood.V122.21.1957.1957 |
0.368 |
|
2013 |
Schlegel J, Sambade M, Sather S, Moschos S, Tan A, Winges A, DeRyckere D, Carson CC, Trembath DG, Tentler JJ, Eckhardt G, Kuan P, Hamilton RL, Duncan LM, Miller CR, ... ... Wang X, et al. Abstract 3037: Mer receptor tyrosine kinase is a novel therapeutic target in melanoma. Cancer Research. 73: 3037-3037. DOI: 10.1158/1538-7445.Am2013-3037 |
0.345 |
|
2012 |
Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP. Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε. Plos One. 7: e41494. PMID 22859992 DOI: 10.1371/Journal.Pone.0041494 |
0.302 |
|
2012 |
Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 148: 228-43. PMID 22265414 DOI: 10.1016/J.Cell.2011.11.030 |
0.662 |
|
2012 |
Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 148: 213-27. PMID 22265413 DOI: 10.1016/J.Cell.2011.11.031 |
0.615 |
|
2012 |
Christoph S, DeRyckere D, Schlegel J, Sather S, McGranahan A, Franzer JK, Trakhimets A, Wang X, Kireev D, Janzen W, Liu J, Yang C, Simpson C, Norris-Drouin J, Frye S, et al. Evaluation of UNC569, a Novel Small Molecule Mer Inhibitor for the Treatment of ALL in Vitro and in Vivo. Blood. 120: 2607-2607. DOI: 10.1182/Blood.V120.21.2607.2607 |
0.322 |
|
2012 |
Lee-Sherick AB, Menachof K, Eisenman KM, McGranahan A, McGary C, Hunsucker SA, Schlegel J, Armistead PM, Liang X, Kireev D, Janzen W, Liu J, Stashko M, Norris-Drouin J, Earp HS, ... Wang X, et al. Mer Receptor Tyrosine Kinase Is A Potential Therapeutic Target in Acute Myeloid Leukemia Blood. 120: 1317-1317. DOI: 10.1182/Blood.V120.21.1317.1317 |
0.336 |
|
2011 |
Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner Cancer Research. 71: 7640-7648. PMID 22049529 DOI: 10.1158/0008-5472.Can-10-3947 |
0.399 |
|
2011 |
Shang L, Wang X. AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation. Autophagy. 7: 924-6. PMID 21521945 DOI: 10.4161/Auto.7.8.15860 |
0.356 |
|
2011 |
Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK Proceedings of the National Academy of Sciences of the United States of America. 108: 4788-4793. PMID 21383122 DOI: 10.1073/Pnas.1100844108 |
0.363 |
|
2011 |
Christoph S, DeRyckere D, Sather S, Wang X, Kireev D, Janzen W, Liu J, Yang C, van Deusen A, Simpson C, Norris-Drouin J, Frye S, Earp HS, Johnson GL, Graham DK. UNC569 As Novel Small Molecule Mer Receptor Tyrosine Kinase Inhibitor for Treatment of ALL Blood. 118: 2589-2589. DOI: 10.1182/Blood.V118.21.2589.2589 |
0.356 |
|
2011 |
Li L, Qi W, Zhou M, Xu X, Harran PG, Wang X, Wang L. Abstract 5423: New diazonamide analogs demonstrate remarkably larger therapeutic window compared to taxanes and vinca alkaloids in rodents Cancer Research. 71: 5423-5423. DOI: 10.1158/1538-7445.Am2011-5423 |
0.315 |
|
2010 |
Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak TW, Wang X. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell. 143: 711-24. PMID 21074248 DOI: 10.1016/J.Cell.2010.10.010 |
0.379 |
|
2010 |
Petersen SL, Peyton M, Minna JD, Wang X. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 11936-41. PMID 20547836 DOI: 10.1073/Pnas.1005667107 |
0.416 |
|
2010 |
Yuan S, Yu X, Topf M, Ludtke SJ, Wang X, Akey CW. Structure of an apoptosome-procaspase-9 CARD complex. Structure (London, England : 1993). 18: 571-83. PMID 20462491 DOI: 10.1016/J.Str.2010.04.001 |
0.315 |
|
2010 |
Greer RM, Peyton M, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. Abstract 3479: SMAC mimetic (JP1201) sensitizes non small cell lung cancers (NSCLCs) to multiple chemotherapy agents and erlotinib in an IAP dependent but TNFα independent manner Cancer Research. 70: 3479-3479. DOI: 10.1158/1538-7445.Am10-3479 |
0.352 |
|
2010 |
Li L, Wei Q, Zhou M, Ramesh V, Wang X, Harran PG, Wang L. Abstract B50: A new class of diazonamide analogs with improved antitumor activity Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B50 |
0.316 |
|
2009 |
He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 137: 1100-11. PMID 19524512 DOI: 10.1016/J.Cell.2009.05.021 |
0.403 |
|
2008 |
Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell. 133: 693-703. PMID 18485876 DOI: 10.1016/J.Cell.2008.03.036 |
0.428 |
|
2008 |
Kim HE, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Molecular Cell. 30: 239-47. PMID 18439902 DOI: 10.1016/J.Molcel.2008.03.014 |
0.734 |
|
2007 |
Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis Cancer Cell. 12: 445-456. PMID 17996648 DOI: 10.1016/J.Ccr.2007.08.029 |
0.417 |
|
2007 |
Wang G, Shang L, Burgett AW, Harran PG, Wang X. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proceedings of the National Academy of Sciences of the United States of America. 104: 2068-73. PMID 17287350 DOI: 10.1073/Pnas.0610832104 |
0.352 |
|
2007 |
Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proceedings of the National Academy of Sciences of the United States of America. 104: 2074-9. PMID 17287337 DOI: 10.1073/Pnas.0611340104 |
0.318 |
|
2006 |
Akdemir F, Farkas R, Chen P, Juhasz G, Medved'ová L, Sass M, Wang L, Wang X, Chittaranjan S, Gorski SM, Rodriguez A, Abrams JM. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development (Cambridge, England). 133: 1457-65. PMID 16540507 DOI: 10.1242/Dev.02332 |
0.39 |
|
2005 |
Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (London, England : 1993). 13: 1725-35. PMID 16271896 DOI: 10.1016/J.Str.2005.09.006 |
0.312 |
|
2005 |
Rand TA, Petersen S, Du F, Wang X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell. 123: 621-9. PMID 16271385 DOI: 10.1016/J.Cell.2005.10.020 |
0.302 |
|
2005 |
Kim HE, Du F, Fang M, Wang X. Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proceedings of the National Academy of Sciences of the United States of America. 102: 17545-50. PMID 16251271 DOI: 10.1073/Pnas.0507900102 |
0.741 |
|
2005 |
Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell. 121: 1085-95. PMID 15989957 DOI: 10.1016/J.Cell.2005.06.009 |
0.389 |
|
2005 |
Hao Z, Duncan GS, Chang CC, Elia A, Fang M, Wakeham A, Okada H, Calzascia T, Jang Y, You-Ten A, Yeh WC, Ohashi P, Wang X, Mak TW. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell. 121: 579-91. PMID 15907471 DOI: 10.1016/J.Cell.2005.03.016 |
0.376 |
|
2004 |
Rand TA, Ginalski K, Grishin NV, Wang X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 14385-9. PMID 15452342 DOI: 10.1073/Pnas.0405913101 |
0.33 |
|
2004 |
Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science (New York, N.Y.). 305: 1471-4. PMID 15353805 DOI: 10.1126/Science.1098231 |
0.416 |
|
2004 |
Hahn HP, Pang M, He J, Hernandez JD, Yang RY, Li LY, Wang X, Liu FT, Baum LG. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death and Differentiation. 11: 1277-86. PMID 15297883 DOI: 10.1038/Sj.Cdd.4401485 |
0.408 |
|
2004 |
Jiang X, Wang X. Cytochrome C-mediated apoptosis. Annual Review of Biochemistry. 73: 87-106. PMID 15189137 DOI: 10.1146/Annurev.Biochem.73.011303.073706 |
0.415 |
|
2004 |
Li P, Nijhawan D, Wang X. Mitochondrial activation of apoptosis. Cell. 116: S57-9, 2 p following. PMID 15055583 DOI: 10.1016/S0092-8674(04)00031-5 |
0.334 |
|
2003 |
Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice Proceedings of the National Academy of Sciences of the United States of America. 100: 15782-15787. PMID 14663139 DOI: 10.1073/Pnas.2636393100 |
0.332 |
|
2003 |
Liu Q, Rand TA, Kalidas S, Du F, Kim HE, Smith DP, Wang X. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (New York, N.Y.). 301: 1921-5. PMID 14512631 DOI: 10.1126/Science.1088710 |
0.709 |
|
2003 |
Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes & Development. 17: 1475-86. PMID 12783855 DOI: 10.1101/Gad.1093903 |
0.408 |
|
2003 |
Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (New York, N.Y.). 299: 223-6. PMID 12522243 DOI: 10.1126/Science.1076807 |
0.745 |
|
2002 |
Deshmukh M, Du C, Wang X, Johnson EM. Exogenous smac induces competence and permits caspase activation in sympathetic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8018-27. PMID 12223555 DOI: 10.1523/Jneurosci.22-18-08018.2002 |
0.364 |
|
2002 |
Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW. Generation and characterization of Smac/DIABLO-deficient mice. Molecular and Cellular Biology. 22: 3509-17. PMID 11971981 DOI: 10.1128/Mcb.22.10.3509-3517.2002 |
0.404 |
|
2002 |
Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Molecular Cell. 9: 423-32. PMID 11864614 DOI: 10.1016/S1097-2765(02)00442-2 |
0.36 |
|
2001 |
Lutter M, Perkins GA, Wang X. The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites. Bmc Cell Biology. 2: 22. PMID 11716782 DOI: 10.1186/1471-2121-2-22 |
0.337 |
|
2001 |
Honarpour N, Tabuchi K, Stark JM, Hammer RE, Südhof TC, Parada LF, Wang X, Richardson JA, Herz J. Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1. Neuroscience. 106: 263-74. PMID 11566499 DOI: 10.1016/S0306-4522(01)00275-5 |
0.563 |
|
2001 |
Honarpour N, Gilbert SL, Lahn BT, Wang X, Herz J. Apaf-1 deficiency and neural tube closure defects are found in fog mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 9683-7. PMID 11504943 DOI: 10.1073/Pnas.171283198 |
0.496 |
|
2001 |
Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 412: 95-9. PMID 11452314 DOI: 10.1038/35083620 |
0.362 |
|
2001 |
Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D. Mitochondrial endonuclease G is important for apoptosis in C. elegans Nature. 412: 90-94. PMID 11452313 DOI: 10.1038/35083608 |
0.396 |
|
2001 |
Yu T, Wang X, Purring-Koch C, Wei Y, McLendon GL. A Mutational Epitope for Cytochrome c Binding to the Apoptosis Protease Activation Factor-1 Journal of Biological Chemistry. 276: 13034-13038. PMID 11112785 DOI: 10.1074/Jbc.M009773200 |
0.359 |
|
2001 |
Mejillano M, Yamamoto M, Rozelle AL, Sun HQ, Wang X, Yin HL. Regulation of Apoptosis by Phosphatidylinositol 4,5-Bisphosphate Inhibition of Caspases, and Caspase Inactivation of Phosphatidylinositol Phosphate 5-Kinases Journal of Biological Chemistry. 276: 1865-1872. PMID 11042212 DOI: 10.1074/Jbc.M007271200 |
0.43 |
|
2000 |
Wu G, Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y. Structural basis of IAP recognition by Smac/DIABLO. Nature. 408: 1008-12. PMID 11140638 DOI: 10.1038/35050012 |
0.389 |
|
2000 |
Lutter M, Fang M, Luo X, Nishijima M, Xie XS, Wang X. Cardiolipin provides specificity for targeting of tBid to mitochondria. Nature Cell Biology. 2: 754-756. PMID 11025668 DOI: 10.1038/35036395 |
0.378 |
|
2000 |
Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 406: 855-62. PMID 10972280 DOI: 10.1038/35022514 |
0.406 |
|
2000 |
Jiang X, Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. Journal of Biological Chemistry. 275: 31199-31203. PMID 10940292 DOI: 10.1074/Jbc.C000405200 |
0.369 |
|
2000 |
Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102: 33-42. PMID 10929711 DOI: 10.1016/S0092-8674(00)00008-8 |
0.421 |
|
2000 |
Liu X, Wang X. In vitro assays for caspase-3 activation and DNA fragmentation. Methods in Enzymology. 322: 177. PMID 10914014 DOI: 10.1016/S0076-6879(00)22017-X |
0.314 |
|
2000 |
Thomas DA, Du C, Xu M, Wang X, Ley TJ. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis. Immunity. 12: 621-32. PMID 10894162 DOI: 10.1016/S1074-7613(00)80213-7 |
0.41 |
|
2000 |
Bala S, Oliver H, Renault B, Montgomery K, Dutta S, Rao P, Houldsworth J, Kucherlapati R, Wang X, Chaganti RS, Murty VV. Genetic analysis of the APAF1 gene in male germ cell tumors. Genes, Chromosomes & Cancer. 28: 258-68. PMID 10862031 DOI: 10.1002/1098-2264(200007)28:3<258::Aid-Gcc3>3.0.Co;2-R |
0.301 |
|
2000 |
Nijhawan D, Honarpour N, Wang X. Apoptosis in Neural Development and Disease Annual Review of Neuroscience. 23: 73-87. PMID 10845059 DOI: 10.1146/Annurev.Neuro.23.1.73 |
0.379 |
|
2000 |
Li K, Li Y, Shelton JM, Richardson JA, Spencer E, Chen ZJ, Wang X, Williams RS. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell. 101: 389-99. PMID 10830166 DOI: 10.1016/S0092-8674(00)80849-1 |
0.369 |
|
2000 |
Honarpour N, Du C, Richardson JA, Hammer RE, Wang X, Herz J. Adult Apaf-1-deficient mice exhibit male infertility. Developmental Biology. 218: 248-58. PMID 10656767 DOI: 10.1006/Dbio.1999.9585 |
0.572 |
|
2000 |
Genini D, Budihardjo I, Plunkett W, Wang X, Carrera CJ, Cottam HB, Carson DA, Leoni LM. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. The Journal of Biological Chemistry. 275: 29-34. PMID 10617581 DOI: 10.1074/Jbc.275.1.29 |
0.416 |
|
1999 |
Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annual Review of Cell and Developmental Biology. 15: 269-90. PMID 10611963 DOI: 10.1146/Annurev.Cellbio.15.1.269 |
0.428 |
|
1999 |
Rodriguez A, Oliver H, Zou H, Chen P, Wang X, Abrams JM. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nature Cell Biology. 1: 272-279. PMID 10559939 DOI: 10.1038/12984 |
0.307 |
|
1999 |
Liu X, Zou H, Widlak P, Garrard W, Wang X. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1 Journal of Biological Chemistry. 274: 13836-13840. PMID 10318789 DOI: 10.1074/Jbc.274.20.13836 |
0.377 |
|
1999 |
Zou H, Li Y, Liu X, Wang X. An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9 Journal of Biological Chemistry. 274: 11549-11556. PMID 10206961 DOI: 10.1074/Jbc.274.17.11549 |
0.364 |
|
1999 |
Purring C, Zou H, Wang X, McLendon G. Stoichiometry, free energy, and kinetic aspects of cytochrome c: Apaf-1 binding in apoptosis [16] Journal of the American Chemical Society. 121: 7435-7436. DOI: 10.1021/Ja991235H |
0.302 |
|
1998 |
Toh SY, Wang X, Li P. Identification of the nuclear factor HMG2 as an activator for DFF nuclease activity. Biochemical and Biophysical Research Communications. 250: 598-601. PMID 9784391 DOI: 10.1006/Bbrc.1998.9369 |
0.364 |
|
1998 |
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94: 481-90. PMID 9727491 DOI: 10.1016/S0092-8674(00)81589-5 |
0.391 |
|
1998 |
Leoni LM, Chao Q, Cottam HB, Genini D, Rosenbach M, Carrera CJ, Budihardjo I, Wang X, Carson DA. Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. Proceedings of the National Academy of Sciences of the United States of America. 95: 9567-71. PMID 9689121 DOI: 10.1073/Pnas.95.16.9567 |
0.395 |
|
1998 |
Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis Proceedings of the National Academy of Sciences of the United States of America. 95: 8461-8466. PMID 9671700 DOI: 10.1073/Pnas.95.15.8461 |
0.342 |
|
1997 |
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91: 479-89. PMID 9390557 DOI: 10.1016/S0092-8674(00)80434-1 |
0.408 |
|
1997 |
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90: 405-13. PMID 9267021 DOI: 10.1016/S0092-8674(00)80501-2 |
0.394 |
|
1997 |
Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89: 175-84. PMID 9108473 DOI: 10.1016/S0092-8674(00)80197-X |
0.381 |
|
1997 |
Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (New York, N.Y.). 275: 1129-32. PMID 9027314 DOI: 10.1126/Science.275.5303.1129 |
0.379 |
|
1996 |
Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86: 147-57. PMID 8689682 DOI: 10.1016/S0092-8674(00)80085-9 |
0.381 |
|
1996 |
Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. The Embo Journal. 15: 1012-20. PMID 8605870 DOI: 10.1002/J.1460-2075.1996.Tb00438.X |
0.659 |
|
1996 |
Liu X, Kim CN, Pohl J, Wang X. Purification and characterization of an interleukin-1beta-converting enzyme family protease that activates cysteine protease P32 (CPP32). Journal of Biological Chemistry. 271: 13371-13376. DOI: 10.1074/Jbc.271.23.13371 |
0.338 |
|
1995 |
Wang X, Pai JT, Wiedenfeld EA, Medina JC, Slaughter CA, Goldstein JL, Brown MS. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. The Journal of Biological Chemistry. 270: 18044-50. PMID 7629113 DOI: 10.1074/Jbc.270.30.18044 |
0.586 |
|
1994 |
Wang X, Sato R, Brown MS, Hua X, Goldstein JL. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77: 53-62. PMID 8156598 DOI: 10.1016/0092-8674(94)90234-8 |
0.575 |
|
1993 |
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75: 187-97. PMID 8402897 DOI: 10.1016/S0092-8674(05)80095-9 |
0.572 |
|
1993 |
Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proceedings of the National Academy of Sciences of the United States of America. 90: 11603-7. PMID 7903453 DOI: 10.1073/Pnas.90.24.11603 |
0.537 |
|
1989 |
Wang XD, Padgett RA. Hydroxyl radical "footprinting" of RNA: application to pre-mRNA splicing complexes. Proceedings of the National Academy of Sciences of the United States of America. 86: 7795-9. PMID 2554290 DOI: 10.1073/Pnas.86.20.7795 |
0.572 |
|
Show low-probability matches. |