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Frantisek Hubalek, Ph.D. - Publications

Affiliations: 
2002 Emory University, Atlanta, GA 
Area:
Biochemistry
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hjorth CF, Norrman M, Wahlund PO, Benie AJ, Petersen BO, Jessen CM, Pedersen TÅ, Vestergaard K, Steensgaard DB, Pedersen JS, Naver H, Hubálek F, Poulsen C, Otzen D. Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin. Journal of Pharmaceutical Sciences. 105: 1376-86. PMID 26921119 DOI: 10.1016/J.Xphs.2016.01.003  0.328
2015 Vinther TN, Kjeldsen TB, Jensen KJ, Hubálek F. The road to the first, fully active and more stable human insulin variant with an additional disulfide bond. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26382042 DOI: 10.1002/Psc.2822  0.32
2015 Vinther TN, Pettersson I, Huus K, Schlein M, Steensgaard DB, Sørensen A, Jensen KJ, Kjeldsen T, Hubalek F. Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability. Protein Science : a Publication of the Protein Society. 24: 779-88. PMID 25627966 DOI: 10.1002/Pro.2649  0.336
2013 Vinther TN, Norrman M, Ribel U, Huus K, Schlein M, Steensgaard DB, Pedersen TÅ, Pettersson I, Ludvigsen S, Kjeldsen T, Jensen KJ, Hubálek F. Insulin analog with additional disulfide bond has increased stability and preserved activity. Protein Science : a Publication of the Protein Society. 22: 296-305. PMID 23281053 DOI: 10.1002/Pro.2211  0.336
2011 Vinther TN, Ribel U, Pedersen TA, Kjeldsen TB, Jensen KJ, Hubálek F. Identification of anchor points for chemical modification of a small cysteine-rich protein by using a cysteine scan. Chembiochem : a European Journal of Chemical Biology. 12: 2448-55. PMID 21905194 DOI: 10.1002/Cbic.201100464  0.348
2010 Andersen AS, Palmqvist E, Bang S, Shaw AC, Hubalek F, Ribel U, Hoeg-Jensen T. Backbone cyclic insulin. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 473-9. PMID 20641002 DOI: 10.1002/Psc.1264  0.322
2008 Binda C, Wang J, Li M, Hubalek F, Mattevi A, Edmondson DE. Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B Biochemistry. 47: 5616-5625. PMID 18426226 DOI: 10.1021/Bi8002814  0.645
2007 Norrman M, Hubálek F, Schluckebier G. Structural characterization of insulin NPH formulations. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 30: 414-23. PMID 17339105 DOI: 10.1016/J.Ejps.2007.01.003  0.317
2006 Binda C, Hubálek F, Li M, Castagnoli N, Edmondson DE, Mattevi A. Structure of the human mitochondrial monoamine oxidase B: New chemical implications for neuroprotectant drug design Neurology. 67: S5-S7. PMID 17030739 DOI: 10.1212/Wnl.67.7_Suppl_2.S5  0.657
2005 Binda C, Hubálek F, Li M, Herzig Y, Sterling J, Edmondson DE, Mattevi A. Binding of rasagiline-related inhibitors to human monoamine oxidases: A kinetic and crystallographic analysis Journal of Medicinal Chemistry. 48: 8148-8154. PMID 16366596 DOI: 10.1021/Jm0506266  0.621
2005 Hubálek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE. Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors Journal of Biological Chemistry. 280: 15761-15766. PMID 15710600 DOI: 10.1074/Jbc.M500949200  0.621
2004 Edmondson DE, Mattevi A, Binda C, Li M, Hubálek F. Structure and mechanism of monoamine oxidase Current Medicinal Chemistry. 11: 1983-1993. PMID 15279562 DOI: 10.1002/0471266949.Bmc111  0.661
2004 Binda C, Hubálek F, Li M, Edmondson DE, Mattevi A. Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane Febs Letters. 564: 225-228. PMID 15111100 DOI: 10.1016/S0014-5793(04)00209-1  0.623
2004 Binda C, Hubálek F, Li M, Herzig Y, Sterling J, Edmondson DE, Mattevi A. Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class Journal of Medicinal Chemistry. 47: 1767-1774. PMID 15027868 DOI: 10.1021/Jm031087C  0.609
2004 Hubálek F, Binda C, Li M, Herzig Y, Sterling J, Youdim MBH, Mattevi A, Edmondson DE. Inactivation of Purified Human Recombinant Monoamine Oxidases A and B by Rasagiline and Its Analogues Journal of Medicinal Chemistry. 47: 1760-1766. PMID 15027867 DOI: 10.1021/Jm0310885  0.583
2004 Mattevi A, Li M, Hubalek F, Edmondson DE, Binda C. Structure of the human outer-mitochondrial membrane monoamine oxidase B at 1.7 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 60: s22-s22. DOI: 10.1107/S0108767304099581  0.574
2003 Ivanov NV, Hubálek F, Trani M, Edmondson DE. Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase. European Journal of Biochemistry / Febs. 270: 4744-54. PMID 14622263 DOI: 10.1046/J.1432-1033.2003.03875.X  0.661
2003 Hubálek F, Binda C, Li M, Mattevi A, Edmondson DE. Polystyrene microbridges used in sitting-drop crystallization release 1,4-diphenyl-2-butene, a novel inhibitor of human MAO B Acta Crystallographica - Section D Biological Crystallography. 59: 1874-1876. PMID 14501143 DOI: 10.1107/S0907444903016883  0.607
2003 Binda C, Li M, Hubálek F, Restelli N, Edmondson DE, Mattevi A. Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures Proceedings of the National Academy of Sciences of the United States of America. 100: 9750-9755. PMID 12913124 DOI: 10.1073/Pnas.1633804100  0.659
2003 Hubalek F, Pohl J, Edmondson DE. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. The Journal of Biological Chemistry. 278: 28612-8. PMID 12777388 DOI: 10.1074/Jbc.M303712200  0.663
2002 Hubálek F, Edmondson DE, Pohl J. Synthesis and characterization of a collagen model delta-O-phosphohydroxylysine-containing peptide. Analytical Biochemistry. 306: 124-34. PMID 12069423 DOI: 10.1006/Abio.2002.5693  0.524
2002 Li M, Hubálek F, Newton-Vinson P, Edmondson DE. High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae. Protein Expression and Purification. 24: 152-62. PMID 11812236 DOI: 10.1006/Prep.2001.1546  0.585
2002 Binda C, Newton-Vinson P, Hubálek F, Edmondson DE, Mattevi A. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nature Structural Biology. 9: 22-6. PMID 11753429 DOI: 10.1038/Nsb732  0.656
2000 Newton-Vinson P, Hubalek F, Edmondson DE. High-level expression of human liver monoamine oxidase B in Pichia pastoris. Protein Expression and Purification. 20: 334-45. PMID 11049757 DOI: 10.1006/Prep.2000.1309  0.624
2000 Miller JR, Guan N, Hubalek F, Edmondson DE. The FAD binding sites of human liver monoamine oxidases A and B: investigation of the role of flavin ribityl side chain hydroxyl groups in the covalent flavinylation reaction and catalytic activities. Biochimica Et Biophysica Acta. 1476: 27-32. PMID 10606764 DOI: 10.1016/S0167-4838(99)00222-8  0.642
1995 Pohl J, Hubalek F, Byrnes ME, Nielsen KR, Woods A, Pennington MW. Assignment of the three disulfide bonds in ShK toxin: A potent potassium channel inhibitor from the sea anemone Stichodactyla helianthus Letters in Peptide Science. 1: 291-297. DOI: 10.1007/Bf00119770  0.343
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