Eric A. Ortlund, Ph.D. - Publications

Affiliations: 
2002 University of South Carolina, Columbia, SC 
Area:
Organic Chemistry, Biochemistry

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/acs.jmedchem.9b00753  0.44
2018 Flynn AR, Mays SG, Ortlund EA, Jui NT. Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1. Acs Medicinal Chemistry Letters. 9: 1051-1056. PMID 30344916 DOI: 10.1021/acsmedchemlett.8b00361  0.44
2018 Frank F, Okafor CD, Ortlund EA. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. Scientific Reports. 8: 13497. PMID 30201977 DOI: 10.1038/s41598-018-31812-9  0.44
2018 Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus. Structure (London, England : 1993). 26: 118-129.e3. PMID 29276038 DOI: 10.1016/j.str.2017.11.018  0.44
2017 Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA. Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin. Journal of Molecular Biology. PMID 28970104 DOI: 10.1016/j.jmb.2017.09.016  0.44
2017 Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA. Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin. Journal of Molecular Biology. PMID 28970104 DOI: 10.1016/j.jmb.2017.09.016  0.44
2017 Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular Pharmacology. PMID 28363985 DOI: 10.1124/mol.117.108514  0.44
2016 Weikum ER, Tuntland ML, Murphy MN, Ortlund EA. A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF) and Liver Receptor Homolog-1 (LRH-1). Journal of Molecular Biology. PMID 27984042 DOI: 10.1016/j.jmb.2016.10.025  0.44
2016 Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec JO, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. The Journal of Biological Chemistry. PMID 27694446 DOI: 10.1074/jbc.M116.753541  0.44
2016 Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA. Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity. The Journal of Biological Chemistry. 291: 1411-26. PMID 26553876 DOI: 10.1074/jbc.M115.662874  1
2015 Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proceedings of the National Academy of Sciences of the United States of America. PMID 26715749 DOI: 10.1073/pnas.1518960113  1
2015 Yu K, Whitlock JM, Lee K, Ortlund EA, Yuan Cui Y, Hartzell HC. Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife. 4. PMID 26057829 DOI: 10.7554/eLife.06901  1
2015 Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR. Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of Biological Chemistry. 290: 9037-49. PMID 25666614 DOI: 10.1074/jbc.M114.634329  1
2015 Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.). 347: 83-6. PMID 25554789 DOI: 10.1126/science.1258857  1
2014 Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications. 5: 5395. PMID 25377354 DOI: 10.1038/ncomms6395  1
2014 Hudson WH, Ortlund EA. The structure, function and evolution of proteins that bind DNA and RNA. Nature Reviews. Molecular Cell Biology. 15: 749-60. PMID 25269475 DOI: 10.1038/nrm3884  1
2014 McKeown AN, Bridgham JT, Anderson DW, Murphy MN, Ortlund EA, Thornton JW. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell. 159: 58-68. PMID 25259920 DOI: 10.1016/j.cell.2014.09.003  1
2014 Hudson WH, Youn C, Ortlund EA. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. Plos One. 9: e107000. PMID 25188500 DOI: 10.1371/journal.pone.0107000  1
2014 Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. The Journal of Biological Chemistry. 289: 14941-54. PMID 24692551 DOI: 10.1074/jbc.M113.514646  1
2014 Qiang G, Xue S, Yang JJ, Du G, Pang X, Li X, Goswami D, Griffin PR, Ortlund EA, Chan CB, Ye K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity. Diabetes. 63: 1394-409. PMID 24651808 DOI: 10.2337/db13-0334  1
2014 Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Evolutionary history and metabolic insights of ancient mammalian uricases Proceedings of the National Academy of Sciences of the United States of America. 111: 3763-3768. PMID 24550457 DOI: 10.1073/pnas.1320393111  1
2014 Horton BM, Hudson WH, Ortlund EA, Shirk S, Thomas JW, Young ER, Zinzow-Kramer WM, Maney DL. Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 111: 1443-8. PMID 24474771 DOI: 10.1073/pnas.1317165111  1
2014 Bridgham JT, Keay J, Ortlund EA, Thornton JW. Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. Plos Genetics. 10: e1004058. PMID 24415950 DOI: 10.1371/journal.pgen.1004058  1
2014 Ren J, Pei-Chen Lin C, Pathak MC, Temple BR, Nile AH, Mousley CJ, Duncan MC, Eckert DM, Leiker TJ, Ivanova PT, Myers DS, Murphy RC, Brown HA, Verdaasdonk J, Bloom KS, ... Ortlund EA, et al. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Molecular Biology of the Cell. 25: 712-27. PMID 24403601 DOI: 10.1091/mbc.E13-11-0634  1
2013 Colucci JK, Ortlund EA. X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. Plos One. 8: e80761. PMID 24260475 DOI: 10.1371/journal.pone.0080761  1
2013 Colucci JK, Ortlund EA. Expression, purification and crystallization of the ancestral androgen receptor-DHT complex. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 994-6. PMID 23989146 DOI: 10.1107/S1744309113018745  1
2013 Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 11475-80. PMID 23798447 DOI: 10.1073/pnas.1303930110  1
2013 Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry. 288: 20702-20712. PMID 23737522 DOI: 10.1074/jbc.M113.472837  1
2013 Musille PM, Kohn JA, Ortlund EA. Phospholipid--driven gene regulation. Febs Letters. 587: 1238-46. PMID 23333623 DOI: 10.1016/j.febslet.2013.01.004  1
2013 Gromiha MM, Pathak MC, Saraboji K, Ortlund EA, Gaucher EA. Hydrophobic environment is a key factor for the stability of thermophilic proteins Proteins: Structure, Function and Bioinformatics. 81: 715-721. PMID 23319168 DOI: 10.1002/prot.24232  1
2013 Hudson WH, Youn C, Ortlund EA. The structural basis of direct glucocorticoid-mediated transrepression. Nature Structural & Molecular Biology. 20: 53-8. PMID 23222642 DOI: 10.1038/nsmb.2456  1
2012 Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW. Evolution of minimal specificity and promiscuity in steroid hormone receptors. Plos Genetics. 8: e1003072. PMID 23166518 DOI: 10.1371/journal.pgen.1003072  1
2012 Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation. Chemmedchem. 7: 1909-14. PMID 22961990 DOI: 10.1002/cmdc.201200307  1
2012 Musille PM, Pathak MC, Lauer JL, Hudson WH, Griffin PR, Ortlund EA. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nature Structural & Molecular Biology. 19: 532-7, S1-2. PMID 22504882 DOI: 10.1038/nsmb.2279  1
2012 Kohn JA, Deshpande K, Ortlund EA. Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors. The Journal of Biological Chemistry. 287: 16267-75. PMID 22437833 DOI: 10.1074/jbc.M112.346411  1
2011 Ren J, Schaaf G, Bankaitis VA, Ortlund EA, Pathak MC. Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1239-43. PMID 22102037 DOI: 10.1107/S1744309111027096  1
2011 Carroll SM, Ortlund EA, Thornton JW. Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. Plos Genetics. 7: e1002117. PMID 21698144 DOI: 10.1371/journal.pgen.1002117  1
2011 Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/nature10111  1
2011 Schaaf G, Dynowski M, Mousley CJ, Shah SD, Yuan P, Winklbauer EM, de Campos MK, Trettin K, Quinones MC, Smirnova TI, Yanagisawa LL, Ortlund EA, Bankaitis VA. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Molecular Biology of the Cell. 22: 892-905. PMID 21248202 DOI: 10.1091/mbc.E10-11-0903  1
2011 Thiruchelvam PT, Lai CF, Hua H, Thomas RS, Hurtado A, Hudson W, Bayly AR, Kyle FJ, Periyasamy M, Photiou A, Spivey AC, Ortlund EA, Whitby RJ, Carroll JS, Coombes RC, et al. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast Cancer Research and Treatment. 127: 385-96. PMID 20607599 DOI: 10.1007/s10549-010-0994-9  1
2010 Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. Plos Biology. 8. PMID 20957188 DOI: 10.1371/journal.pbio.1000497  1
2010 Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection. Proceedings of the National Academy of Sciences of the United States of America. 107: 1948-53. PMID 20080675 DOI: 10.1073/pnas.0908463107  1
2009 Bridgham JT, Ortlund EA, Thornton JW. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 461: 515-9. PMID 19779450 DOI: 10.1038/nature08249  1
2008 Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/j.molcel.2007.11.026  1
2007 Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/science.1142819  1
2007 Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. Biochimica Et Biophysica Acta. 1774: 637-44. PMID 17452033 DOI: 10.1016/j.bbapap.2007.03.004  1
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/j.jmb.2005.10.009  1
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/nsmb910  1
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