Eric A. Ortlund, Ph.D. - Publications

Affiliations: 
2002 University of South Carolina, Columbia, SC 
Area:
Organic Chemistry, Biochemistry

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Imai N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance. Hepatology (Baltimore, Md.). PMID 34433228 DOI: 10.1002/hep.32122  1
2021 Liu X, Weikum ER, Tilo D, Vinson C, Ortlund EA. Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element. Nucleic Acids Research. PMID 34289059 DOI: 10.1093/nar/gkab605  1
2021 Frank F, Liu X, Ortlund EA. Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34285072 DOI: 10.1073/pnas.2024685118  1
2021 Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice. Nature Communications. 12: 3493. PMID 34108467 DOI: 10.1038/s41467-021-23595-x  1
2021 Bruno NE, Nwachukwu JC, Srinivasan S, Nettles CC, Izard T, Jin Z, Nowak J, Cameron MD, Boregowda SV, Phinney DG, Elemento O, Liu X, Ortlund EA, Houtman R, Stavreva DA, et al. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nature Chemical Biology. PMID 33510451 DOI: 10.1038/s41589-020-00719-w  1
2020 Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry. 296: 100024. PMID 33410399 DOI: 10.1074/jbc.RA120.016009  1
2020 Mays SG, Stec J, Liu X, D'Agostino EH, Whitby RJ, Ortlund EA. Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist. Scientific Reports. 10: 22279. PMID 33335203 DOI: 10.1038/s41598-020-79251-9  1
2020 Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of Biological Chemistry. PMID 33154163 DOI: 10.1074/jbc.RA120.016009  1
2020 Moody JC, Qadota H, Reedy AR, Okafor CD, Shanmugan N, Matsunaga Y, Christian CJ, Ortlund EA, Benian GM. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Nature Communications. 11: 5010. PMID 33024114 DOI: 10.1038/s41467-020-18852-4  1
2020 Liu X, Wang Y, Gutierrez JS, Damsker JM, Nagaraju K, Hoffman EP, Ortlund EA. Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. Proceedings of the National Academy of Sciences of the United States of America. PMID 32917814 DOI: 10.1073/Pnas.2006890117  1
2020 Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32820071 DOI: 10.1073/Pnas.2003877117  1
2020 Maner-Smith KM, Goll JB, Khadka M, Jensen TL, Colucci JK, Gelber CE, Albert CJ, Bosinger SE, Franke JD, Natrajan M, Rouphael N, Johnson RA, Sanz P, Anderson EJ, Hoft DF, ... ... Ortlund EA, et al. Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination. Vaccines. 8. PMID 32722213 DOI: 10.3390/Vaccines8030414  1
2020 Frank F, Kavousi N, Bountali A, Dammer EB, Mourtada-Maarabouni M, Ortlund EA. The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions. Cell Reports. 32: 107933. PMID 32697996 DOI: 10.1016/J.Celrep.2020.107933  1
2020 Cornelison JL, Cato ML, Johnson AM, D'Agostino EH, Melchers D, Patel AB, Mays SG, Houtman R, Ortlund EA, Jui NT. Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. Bioorganic & Medicinal Chemistry Letters. 30: 127293. PMID 32631515 DOI: 10.1016/J.Bmcl.2020.127293  1
2020 Wolfarth AA, Liu X, Darby TM, Boyer DJ, Spizman JB, Owens JA, Chandrasekharan B, Naudin CR, Hanley KZ, Robinson BS, Ortlund EA, Jones RM, Neish AS. Proline rich acidic protein-1 (PRAP1) protects the gastrointestinal epithelium from irradiation-induced apoptosis. Cellular and Molecular Gastroenterology and Hepatology. PMID 32629119 DOI: 10.1016/J.Jcmgh.2020.06.011  1
2020 Suthar MS, Zimmerman M, Kauffman R, Mantus G, Linderman S, Vanderheiden A, Nyhoff L, Davis C, Adekunle S, Affer M, Sherman M, Reynolds S, Verkerke H, Alter DN, Guarner J, ... ... Ortlund E, et al. Rapid generation of neutralizing antibody responses in COVID-19 patients. Medrxiv : the Preprint Server For Health Sciences. PMID 32511565 DOI: 10.1101/2020.05.03.20084442  1
2020 Steensels S, Qiao J, Zhang Y, Maner-Smith KM, Kika N, Holman CD, Corey KE, Bracken WC, Ortlund EA, Ersoy BA. Acot9 traffics mitochondrial short-chain fatty acids towards de novo lipogenesis and glucose production in the liver. Hepatology (Baltimore, Md.). PMID 32498134 DOI: 10.1002/Hep.31409  0.01
2020 Knudsen NH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Starost KA, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, ... ... Ortlund EA, et al. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science (New York, N.Y.). 368. PMID 32355002 DOI: 10.1126/Science.Aat3987  0.01
2020 D'Agostino EH, Flynn AR, Cornelison JL, Mays SG, Patel A, Jui NT, Ortlund EA. Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors. Acs Medicinal Chemistry Letters. 11: 365-370. PMID 32184971 DOI: 10.1021/Acsmedchemlett.9B00442  1
2020 Naudin CR, Maner-Smith K, Owens JA, Wynn GM, Robinson BS, Matthews JD, Reedy AR, Luo L, Wolfarth AA, Darby TM, Ortlund EA, Jones RM. Lactococcus Lactis subsp. cremoris Elicits Protection Against Metabolic Changes Induced by a Western-style Diet. Gastroenterology. PMID 32169430 DOI: 10.1053/J.Gastro.2020.03.010  1
2019 Okafor CD, Hercules D, Kell SA, Ortlund EA. Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors. Structure (London, England : 1993). PMID 31831214 DOI: 10.1016/J.Str.2019.11.012  1
2019 Mays S, Flynn AR, Cornelison J, Okafor CD, Wang H, Wang G, Huang X, Donaldson H, Millings E, Polavarapu R, Moore D, Calvert J, Jui NT, Ortlund EA. Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design. Journal of Medicinal Chemistry. PMID 31419141 DOI: 10.1021/Acs.Jmedchem.9B00753  1
2019 Liu X, Wang Y, Ortlund EA. First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-PGC1lower case Greek alpha Complex with Endogenous and Synthetic Glucocorticoids. Molecular Pharmacology. PMID 31391291 DOI: 10.1124/Mol.119.116806  1
2019 Tillman MC, Khadka M, Duffy J, Wang MC, Ortlund EA. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Scientific Reports. 9: 9966. PMID 31292465 DOI: 10.1038/S41598-019-46230-8  1
2019 Khadka M, Todor A, Maner-Smith KM, Colucci JK, Tran V, Gaul DA, Anderson EJ, Natrajan MS, Rouphael N, Mulligan MJ, McDonald CE, Suthar M, Li S, Ortlund EA. The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry. Biomolecules. 9. PMID 31126114 DOI: 10.3390/biom9050200  1
2019 Cordy RJ, Patrapuvich R, Lili LN, Cabrera-Mora M, Chien JT, Tharp GK, Khadka M, Meyer EV, Lapp SA, Joyner CJ, Garcia A, Banton S, Tran V, Luvira V, Rungin S, ... ... Ortlund EA, et al. Distinct amino acid and lipid perturbations characterize acute versus chronic malaria. Jci Insight. 4. PMID 31045574 DOI: 10.1172/Jci.Insight.125156  1
2018 Alves-Bezerra M, Li Y, Acuña M, Ivanova AA, Corey KE, Ortlund EA, Cohen DE. Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis. Hepatology (Baltimore, Md.). PMID 30516845 DOI: 10.1002/Hep.30411  1
2018 Flynn AR, Mays SG, Ortlund EA, Jui NT. Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1. Acs Medicinal Chemistry Letters. 9: 1051-1056. PMID 30344916 DOI: 10.1021/Acsmedchemlett.8B00361  1
2018 Collins JM, Walker DI, Jones DP, Tukvadze N, Liu KH, Tran VT, Uppal K, Frediani JK, Easley KA, Shenvi N, Khadka M, Ortlund EA, Kempker RR, Blumberg HM, Ziegler TR. High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans. Plos One. 13: e0205398. PMID 30308073 DOI: 10.1371/Journal.Pone.0205398  1
2018 Frank F, Okafor CD, Ortlund EA. The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor. Scientific Reports. 8: 13497. PMID 30201977 DOI: 10.1038/S41598-018-31812-9  1
2018 Weikum ER, Liu X, Ortlund EA. The nuclear receptor superfamily: A structural perspective. Protein Science : a Publication of the Protein Society. PMID 30109749 DOI: 10.1002/Pro.3496  1
2018 Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R. Delimiting the autoinhibitory module of von Willebrand factor. Journal of Thrombosis and Haemostasis : Jth. PMID 30053340 DOI: 10.1111/Jth.14251  1
2018 Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, ... Ortlund EA, et al. Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity. 49: 42-55.e6. PMID 30021146 DOI: 10.1016/J.Immuni.2018.06.011  0.01
2018 Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature Communications. 9: 1337. PMID 29626214 DOI: 10.1038/S41467-018-03780-1  1
2018 Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA. Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus. Structure (London, England : 1993). 26: 118-129.e3. PMID 29276038 DOI: 10.1016/J.Str.2017.11.018  1
2017 Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA. Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin. Journal of Molecular Biology. PMID 28970104 DOI: 10.1016/J.Jmb.2017.09.016  1
2017 Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA. Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin. Journal of Molecular Biology. PMID 28970104 DOI: 10.1016/J.Jmb.2017.09.016  1
2017 Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Research. PMID 28591827 DOI: 10.1093/Nar/Gkx509  1
2017 Weikum ER, Okafor DC, D'Agostino EH, Colucci JK, Ortlund EA. Structural analysis of the glucocorticoid receptor ligand-binding domain in complex with triamcinolone acetonide and a fragment of the atypical coregulator, SHP. Molecular Pharmacology. PMID 28396564 DOI: 10.1124/Mol.117.108506  1
2017 Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular Pharmacology. PMID 28363985 DOI: 10.1124/Mol.117.108514  1
2017 Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nature Reviews. Molecular Cell Biology. PMID 28053348 DOI: 10.1038/Nrm.2016.152  1
2016 Weikum ER, Tuntland ML, Murphy MN, Ortlund EA. A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF) and Liver Receptor Homolog-1 (LRH-1). Journal of Molecular Biology. PMID 27984042 DOI: 10.1016/J.Jmb.2016.10.025  1
2016 Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec JO, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. The Journal of Biological Chemistry. PMID 27694446 DOI: 10.1074/Jbc.M116.753541  1
2016 Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA. Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity. The Journal of Biological Chemistry. 291: 1411-26. PMID 26553876 DOI: 10.1074/Jbc.M115.662874  1
2015 Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proceedings of the National Academy of Sciences of the United States of America. PMID 26715749 DOI: 10.1073/Pnas.1518960113  1
2015 Yu K, Whitlock JM, Lee K, Ortlund EA, Yuan Cui Y, Hartzell HC. Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife. 4. PMID 26057829 DOI: 10.7554/Elife.06901  1
2015 Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR. Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). The Journal of Biological Chemistry. 290: 9037-49. PMID 25666614 DOI: 10.1074/Jbc.M114.634329  1
2015 Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science (New York, N.Y.). 347: 83-6. PMID 25554789 DOI: 10.1126/Science.1258857  1
2015 Yu K, Whitlock JM, Lee K, Ortlund EA, Cui YY, Hartzell HC. Author response: Identification of a lipid scrambling domain in ANO6/TMEM16F Elife. DOI: 10.7554/Elife.06901.020  1
2014 Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA. Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications. 5: 5395. PMID 25377354 DOI: 10.1038/Ncomms6395  1
2014 Hudson WH, Ortlund EA. The structure, function and evolution of proteins that bind DNA and RNA. Nature Reviews. Molecular Cell Biology. 15: 749-60. PMID 25269475 DOI: 10.1038/Nrm3884  1
2014 McKeown AN, Bridgham JT, Anderson DW, Murphy MN, Ortlund EA, Thornton JW. Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell. 159: 58-68. PMID 25259920 DOI: 10.1016/J.Cell.2014.09.003  1
2014 Hudson WH, Youn C, Ortlund EA. Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. Plos One. 9: e107000. PMID 25188500 DOI: 10.1371/Journal.Pone.0107000  1
2014 Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. The Journal of Biological Chemistry. 289: 14941-54. PMID 24692551 DOI: 10.1074/Jbc.M113.514646  1
2014 Qiang G, Xue S, Yang JJ, Du G, Pang X, Li X, Goswami D, Griffin PR, Ortlund EA, Chan CB, Ye K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity. Diabetes. 63: 1394-409. PMID 24651808 DOI: 10.2337/Db13-0334  1
2014 Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Evolutionary history and metabolic insights of ancient mammalian uricases Proceedings of the National Academy of Sciences of the United States of America. 111: 3763-3768. PMID 24550457 DOI: 10.1073/Pnas.1320393111  1
2014 Horton BM, Hudson WH, Ortlund EA, Shirk S, Thomas JW, Young ER, Zinzow-Kramer WM, Maney DL. Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 111: 1443-8. PMID 24474771 DOI: 10.1073/Pnas.1317165111  1
2014 Bridgham JT, Keay J, Ortlund EA, Thornton JW. Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. Plos Genetics. 10: e1004058. PMID 24415950 DOI: 10.1371/Journal.Pgen.1004058  1
2014 Ren J, Pei-Chen Lin C, Pathak MC, Temple BR, Nile AH, Mousley CJ, Duncan MC, Eckert DM, Leiker TJ, Ivanova PT, Myers DS, Murphy RC, Brown HA, Verdaasdonk J, Bloom KS, ... Ortlund EA, et al. A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Molecular Biology of the Cell. 25: 712-27. PMID 24403601 DOI: 10.1091/Mbc.E13-11-0634  1
2014 Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund E. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway. Journal of Biological Chemistry. 289: 14941-14954. DOI: 10.2210/Pdb4Lkp/Pdb  1
2013 Colucci JK, Ortlund EA. X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface. Plos One. 8: e80761. PMID 24260475 DOI: 10.1371/Journal.Pone.0080761  1
2013 Colucci JK, Ortlund EA. Expression, purification and crystallization of the ancestral androgen receptor-DHT complex. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 994-6. PMID 23989146 DOI: 10.1107/S1744309113018745  1
2013 Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 11475-80. PMID 23798447 DOI: 10.1073/Pnas.1303930110  1
2013 Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry. 288: 20702-20712. PMID 23737522 DOI: 10.1074/Jbc.M113.472837  1
2013 Musille PM, Kohn JA, Ortlund EA. Phospholipid--driven gene regulation. Febs Letters. 587: 1238-46. PMID 23333623 DOI: 10.1016/J.Febslet.2013.01.004  1
2013 Gromiha MM, Pathak MC, Saraboji K, Ortlund EA, Gaucher EA. Hydrophobic environment is a key factor for the stability of thermophilic proteins Proteins: Structure, Function and Bioinformatics. 81: 715-721. PMID 23319168 DOI: 10.1002/Prot.24232  1
2013 Hudson WH, Youn C, Ortlund EA. The structural basis of direct glucocorticoid-mediated transrepression. Nature Structural & Molecular Biology. 20: 53-8. PMID 23222642 DOI: 10.1038/Nsmb.2456  1
2012 Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW. Evolution of minimal specificity and promiscuity in steroid hormone receptors. Plos Genetics. 8: e1003072. PMID 23166518 DOI: 10.1371/Journal.Pgen.1003072  1
2012 Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation. Chemmedchem. 7: 1909-14. PMID 22961990 DOI: 10.1002/Cmdc.201200307  1
2012 Musille PM, Pathak MC, Lauer JL, Hudson WH, Griffin PR, Ortlund EA. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nature Structural & Molecular Biology. 19: 532-7, S1-2. PMID 22504882 DOI: 10.1038/Nsmb.2279  1
2012 Kohn JA, Deshpande K, Ortlund EA. Deciphering modern glucocorticoid cross-pharmacology using ancestral corticosteroid receptors. The Journal of Biological Chemistry. 287: 16267-75. PMID 22437833 DOI: 10.1074/Jbc.M112.346411  1
2011 Ren J, Schaaf G, Bankaitis VA, Ortlund EA, Pathak MC. Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1239-43. PMID 22102037 DOI: 10.1107/S1744309111027096  1
2011 Carroll SM, Ortlund EA, Thornton JW. Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor. Plos Genetics. 7: e1002117. PMID 21698144 DOI: 10.1371/Journal.Pgen.1002117  1
2011 Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/Nature10111  1
2011 Schaaf G, Dynowski M, Mousley CJ, Shah SD, Yuan P, Winklbauer EM, de Campos MK, Trettin K, Quinones MC, Smirnova TI, Yanagisawa LL, Ortlund EA, Bankaitis VA. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Molecular Biology of the Cell. 22: 892-905. PMID 21248202 DOI: 10.1091/Mbc.E10-11-0903  1
2011 Thiruchelvam PT, Lai CF, Hua H, Thomas RS, Hurtado A, Hudson W, Bayly AR, Kyle FJ, Periyasamy M, Photiou A, Spivey AC, Ortlund EA, Whitby RJ, Carroll JS, Coombes RC, et al. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast Cancer Research and Treatment. 127: 385-96. PMID 20607599 DOI: 10.1007/S10549-010-0994-9  1
2010 Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor. Plos Biology. 8. PMID 20957188 DOI: 10.1371/Journal.Pbio.1000497  1
2010 Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection. Proceedings of the National Academy of Sciences of the United States of America. 107: 1948-53. PMID 20080675 DOI: 10.1073/Pnas.0908463107  1
2009 Bridgham JT, Ortlund EA, Thornton JW. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 461: 515-9. PMID 19779450 DOI: 10.1038/Nature08249  1
2008 Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/J.Molcel.2007.11.026  1
2007 Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/Science.1142819  1
2007 Chiswell B, Lovelace LL, Brannen C, Ortlund EA, Lebioda L, Sodetz JM. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. Biochimica Et Biophysica Acta. 1774: 637-44. PMID 17452033 DOI: 10.1016/J.Bbapap.2007.03.004  1
2005 Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/J.Jmb.2005.10.009  1
2005 Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910  1
2003 Chruszcz M, Laidler P, Monkiewicz M, Ortlund E, Lebioda L, Lewinski K. Crystal structure of a covalent intermediate of endogenous human arylsulfatase A. Journal of Inorganic Biochemistry. 96: 386-92. PMID 12888274 DOI: 10.1016/S0162-0134(03)00176-4  1
2003 Ortlund E, LaCount MW, Lebioda L. Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design. Biochemistry. 42: 383-9. PMID 12525165 DOI: 10.1021/Bi0265067  1
2002 Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L. Crystal structure of human complement protein C8γ at 1.2 Å resolution reveals a lipocalin fold and a distinct ligand binding site Biochemistry. 41: 7030-7037. PMID 12033936 DOI: 10.1021/Bi025696I  1
2000 Ortlund E, Lacount MW, Lewinski K, Lebioda L. Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu. Biochemistry. 39: 1199-204. PMID 10684596 DOI: 10.1021/Bi991797D  1
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