Andrei V. Gudkov - Publications

Affiliations: 
1990-2001 Molecular Genetics University of Illinois at Chicago, Chicago, IL, United States 
 2001-2007 Molecular Biology and Professor of Biochemistry Case Western Reserve University, Cleveland Heights, OH, United States 
 2007- Roswell Park . Cellular and Molecular Biology State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Molecular Biology, General Biology, Immunology, Oncology
Website:
https://www.roswellpark.org/andrei-gudkov

187 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Novototskaya-Vlasova KA, Neznanov NS, Molodtsov I, Hall BM, Commane M, Gleiberman AS, Murray J, Haber M, Norris MD, Leonova KI, Gudkov AV. Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2213146119. PMID 36449545 DOI: 10.1073/pnas.2213146119  0.321
2020 Antoch MP, Wrobel M, Gillard B, Kuropatwinski KK, Toshkov I, Gleiberman AS, Karasik E, Moser MT, Foster BA, Andrianova EL, Chernova OV, Gudkov AV. Superior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer. Oncotarget. 11: 1373-1387. PMID 32341756 DOI: 10.18632/Oncotarget.27550  0.345
2020 Eremina NV, Kazey VI, Mishugin SV, Leonenkov RV, Pushkar DY, Mett VL, Gudkov AV. First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients. Oncotarget. 11: 1273-1288. PMID 32292576 DOI: 10.18632/Oncotarget.27549  0.325
2020 Haderski GJ, Kandar BM, Brackett CM, Toshkov IM, Johnson CP, Paszkiewicz GM, Natarajan V, Gleiberman AS, Gudkov AV, Burdelya LG. TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects. Plos One. 15: e0227940. PMID 32027657 DOI: 10.1371/Journal.Pone.0227940  0.355
2020 Korotchkina L, Kazyulkin D, Komarov PG, Polinsky A, Andrianova EL, Joshi S, Gupta M, Vujcic S, Kononov E, Toshkov I, Tian Y, Krasnov P, Chernov MV, Veith J, Antoch MP, ... ... Gudkov AV, et al. OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis. Leukemia. PMID 31896781 DOI: 10.1038/S41375-019-0692-5  0.379
2020 Sarantopoulos J, Mahalingam D, Sharma N, Iyer RV, Ma WW, Ahluwalia MS, Johnson S, Purmal A, Shpigotskaya P, Hards A, Leonov A, Gurova K, Gudkov A, Zakurdaeva K, Miller LL, et al. Results of a completed phase I trial of CBL0137 administered intravenously (IV) to patients (Pts) with advanced solid tumors. Journal of Clinical Oncology. 38: 3583-3583. DOI: 10.1200/Jco.2020.38.15_Suppl.3583  0.314
2020 Haber M, Gamble L, Xiao L, Pandher R, Somers K, Murray J, Khan A, Yu D, Franshaw L, Burns MR, Tsoli M, Ehteda A, Cesare A, O’Connor A, Mussai F, ... ... Gudkov AV, et al. Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Ia13  0.363
2020 Leonova K, Safina A, Gudkov AV, Gurova KV. Abstract 4496: Induction of immunogenicity in tumor cells by small molecule drugs that destabilize nucleosomes Cancer Research. 80: 4496-4496. DOI: 10.1158/1538-7445.Am2020-4496  0.425
2019 Somers K, Evans K, Cheung L, Karsa M, Pritchard T, Kosciolek A, Bongers A, El-Ayoubi A, Forgham H, Middlemiss S, Mayoh C, Jones L, Gupta M, Kees UR, Chernova O, ... ... Gudkov AV, et al. Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia. Leukemia. PMID 31848452 DOI: 10.1038/S41375-019-0683-6  0.32
2019 Kirsanov KI, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, Salimov R, Shipaeva E, Ivanov R, Leonov A, Purmal AA, ... ... Gudkov AV, et al. Prevention of colorectal carcinogenesis by DNA binding small molecule curaxin CBL0137 involves suppression of Wnt signaling. Cancer Prevention Research (Philadelphia, Pa.). PMID 31653646 DOI: 10.1158/1940-6207.Capr-19-0198  0.404
2019 Somers K, Kosciolek A, Bongers A, El-Ayoubi A, Karsa M, Mayoh C, Wadham C, Middlemiss S, Neznanov N, Kees UR, Lock RB, Gudkov AV, Sutton R, Gurova K, Haber M, et al. Potent anti-leukemic activity of curaxin CBL0137 against MLL-rearranged leukemia. International Journal of Cancer. PMID 31325323 DOI: 10.1002/Ijc.32582  0.347
2019 Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, ... ... Gudkov AV, et al. LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metabolism. PMID 30853213 DOI: 10.1016/J.Cmet.2019.02.014  0.302
2019 Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE. Cells exhibiting strong promoter activation in vivo display features of senescence. Proceedings of the National Academy of Sciences of the United States of America. PMID 30683717 DOI: 10.1073/Pnas.1818313116  0.392
2019 Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, ... ... Gudkov AV, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. PMID 30670779 DOI: 10.1038/S41388-018-0666-5  0.357
2019 Valli E, Xue C, Cheung L, Gamble L, Pandher R, Giacomo SD, Burkhart C, Fedtsova N, Ferrucci F, Makarov S, Telfer T, Codd R, Scott D, Perini G, Osterman A, ... Gudkov A, et al. Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation Cancer Research. 79: 2616-2616. DOI: 10.1158/1538-7445.Am2019-2616  0.347
2018 Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, ... ... Gudkov AV, et al. Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. The Journal of Clinical Investigation. PMID 30198908 DOI: 10.1172/Jci70712  0.362
2018 Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, Wang J, Kirsanov K, Yakubovskaya MG, Gudkov AV, Gurova K. TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells. Elife. 7. PMID 29400649 DOI: 10.7554/Elife.30842  0.39
2017 Mett V, Komarova EA, Greene K, Bespalov I, Brackett C, Gillard B, Gleiberman AS, Toshkov IA, Aygün-Sunar S, Johnson C, Karasik E, Bapardekar-Nair M, Kurnasov OV, Osterman AL, Stanhope-Baker PS, ... ... Gudkov AV, et al. Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy. Oncogene. PMID 28967901 DOI: 10.1038/Onc.2017.346  0.383
2017 Frescas D, Hall B, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV. Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent. Cell Cycle (Georgetown, Tex.). 0. PMID 28650766 DOI: 10.1080/15384101.2017.1339850  0.405
2017 Frescas D, Roux CM, Aygun-Sunar S, Gleiberman AS, Krasnov P, Kurnasov OV, Strom E, Virtuoso LP, Wrobel M, Osterman AL, Antoch MP, Mett V, Chernova OB, Gudkov AV. Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193858 DOI: 10.1073/Pnas.1614661114  0.32
2017 Evans K, Pritchard T, Henderson MJ, Somers K, Karsa M, Cheung L, Yung R, Erickson SW, Korotchkina L, Chernova O, Gudkov A, Smith MA, Lock RB. Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibitsin vitroandin vivoefficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia Cancer Research. 77: 1942-1942. DOI: 10.1158/1538-7445.Am2017-1942  0.376
2017 Somers K, Middlemiss S, Biktasova A, Karsa M, Cheung L, Kosciolek A, Evans K, Mayoh C, Kees UR, Korotchkina L, Chernova OB, Lock RB, Gudkov AV, Haber M, Norris MD, et al. Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia Cancer Research. 77: 1175-1175. DOI: 10.1158/1538-7445.Am2017-1175  0.346
2016 Kim M, Neznanov N, Wilfong CD, Fleyshman DI, Purmal AA, Haderski G, Stanhope-Baker P, Burkhart C, Gurova KV, Gudkov AV, Skitzki JJ. Preclinical validation of a single-treatment infusion modality that can eradicate extremity melanomas. Cancer Research. PMID 27680682 DOI: 10.1158/0008-5472.Can-15-2764  0.333
2016 Lock R, Carol H, Maris JM, Kolb EA, Gorlick R, Reynolds CP, Kang MH, Keir ST, Wu J, Purmal A, Gudkov A, Kurmashev D, Kurmasheva RT, Houghton PJ, Smith MA. Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program. Pediatric Blood & Cancer. PMID 27650817 DOI: 10.1002/Pbc.26263  0.331
2016 Gudkov AV, Komarova EA. p53 and the Carcinogenicity of Chronic Inflammation. Cold Spring Harbor Perspectives in Medicine. PMID 27549311 DOI: 10.1101/Cshperspect.A026161  0.42
2016 Barone TA, Burkhart CA, Safina A, Haderski G, Gurova KV, Purmal AA, Gudkov AV, Plunkett RJ. Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. Neuro-Oncology. PMID 27370399 DOI: 10.1093/Neuonc/Now141  0.368
2016 Somers K, Chudakova DA, Middlemiss SM, Wen VW, Clifton M, Kwek A, Liu B, Mayoh C, Bongers A, Karsa M, Pan S, Cruikshank S, Scandlyn M, Hoang W, Imamura T, ... ... Gudkov AV, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. PMID 27317766 DOI: 10.18632/Oncotarget.10022  0.332
2016 Komarov AP, Komarova EA, Green K, Novototskaya LR, Baker PS, Eroshkin A, Osterman AL, Chenchick AA, Frangou C, Gudkov AV. Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure. Cell Death & Disease. 7: e2145. PMID 26986512 DOI: 10.1038/Cddis.2016.45  0.367
2016 Brackett CM, Kojouharov B, Veith J, Greene KF, Burdelya LG, Gollnick SO, Abrams SI, Gudkov AV. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831100 DOI: 10.1073/Pnas.1521359113  0.373
2016 Brackett C, Kojouharov B, Gollnick S, Gudkov A, Burdelya L. Abstract B090: A Toll-like receptor 5 agonist entolimod as a potential anticancer immunotherapeutic agent Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B090  0.379
2016 Chudakova D, Somers K, Middlemiss S, Wen V, Kwek A, Liu B, Clifton M, Pan S, Cruikshank S, Scandlyn M, Failes T, Hoang W, Kees U, Chernova O, Gudkov AV, et al. Abstract B23: Selective and rapid killing of mixed lineage leukemia and CALM-AF10 leukemia by SM7, a novel small molecule identified by chemical library screening Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-B23  0.39
2016 Sharma N, Dermawan J, Purmal A, Lindner D, Wildey G, Dowlati A, Gudkov A, Gurova K, Stark GR. Abstract 3036: Targeting FACT complex with CBL0137 to overcome acquired resistance to EGFR-TKI in lung adenocarcinoma Cancer Research. 76: 3036-3036. DOI: 10.1158/1538-7445.Am2016-3036  0.328
2015 Yang H, Brackett CM, Morales-Tirado VM, Li Z, Zhang Q, Wilson MW, Benjamin C, Harris W, Waller EK, Gudkov AV, Burdelya LG, Grossniklaus HE. The toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism. Oncotarget. PMID 26655090 DOI: 10.18632/Oncotarget.6500  0.362
2015 Tanne A, Muniz LR, Puzio-Kuter A, Leonova KI, Gudkov AV, Ting DT, Monasson R, Cocco S, Levine AJ, Bhardwaj N, Greenbaum BD. Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26575629 DOI: 10.1073/Pnas.1517584112  0.378
2015 Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford AJ, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, ... ... Gudkov AV, et al. Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma. Science Translational Medicine. 7: 312ra176. PMID 26537256 DOI: 10.1126/Scitranslmed.Aab1803  0.39
2015 Kim M, Barone TA, Fedtsova N, Gleiberman A, Wilfong CD, Alosi JA, Plunkett RJ, Gudkov A, Skitzki JJ. A murine model of targeted infusion for intracranial tumors. Journal of Neuro-Oncology. PMID 26376657 DOI: 10.1007/S11060-015-1942-7  0.314
2015 Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E. The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. Plos One. 10: e0135388. PMID 26367124 DOI: 10.1371/Journal.Pone.0135388  0.306
2015 Erath J, Gallego-Delgado J, Xu W, Andriani G, Tanghe S, Gurova KV, Gudkov A, Purmal A, Rydkina E, Rodriguez A. Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle. Antimicrobial Agents and Chemotherapy. 59: 1427-34. PMID 25512429 DOI: 10.1128/Aac.04704-14  0.303
2015 Frangou C, Den Haese J, Warunek J, Portwood S, Nowak NJ, Gudkov AV, Gurova K, Wetzler M, Wang ES. Functional Genomics and Computational Approaches Identify Novel Small Molecules Targeting Quiescent Leukemia Stem Cells Blood. 126: 1391-1391. DOI: 10.1182/Blood.V126.23.1391.1391  0.396
2015 Carter DR, Murray J, Cheung BB, Kalla H, Gamble L, Tsang J, Sutton S, Koach J, Syed S, Gifford A, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, ... ... Gudkov AV, et al. Abstract PR09: MYCN and is a therapeutic target in neuroblastoma Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-Pr09  0.408
2015 Wierzbicki AJ, Adjei AA, Ngamphaiboon N, Reungwetwattana T, Gudkov AV, Adjei AA. Abstract 5492: Functional characterization of human toll-like receptor 5 (TLR5) genetic variants Cancer Research. 75: 5492-5492. DOI: 10.1158/1538-7445.Am2015-5492  0.328
2015 Haber M, Murray J, Gamble L, Carnegie-Clark A, Webber H, Ruhle M, Henderson MJ, Middlemass S, Carter D, Tsoli M, Ehteda A, Simon S, Oberthuer A, Fischer M, Gurova K, ... ... Gudkov AV, et al. Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting Cancer Research. 75: 1611-1611. DOI: 10.1158/1538-7445.Am2015-1611  0.378
2014 Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochemical Pharmacology. 91: 97-108. PMID 24973542 DOI: 10.1016/J.Bcp.2014.05.023  0.32
2014 Kojouharov BM, Brackett CM, Veith JM, Johnson CP, Gitlin II, Toshkov IA, Gleiberman AS, Gudkov AV, Burdelya LG. Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice. Oncotarget. 5: 802-14. PMID 24583651 DOI: 10.18632/Oncotarget.1773  0.334
2014 Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AV. Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation. Proceedings of the National Academy of Sciences of the United States of America. 111: E474-83. PMID 24474797 DOI: 10.1073/Pnas.1311945111  0.369
2014 Leigh ND, Bian G, Ding X, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X. A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity. Plos One. 9: e85587. PMID 24454895 DOI: 10.1371/Journal.Pone.0085587  0.362
2014 Burkhart C, Kohrn R, Walker B, Gurova K, Purmal A, Gudkov A. Abstract 815: CBL0137 demonstrates significant antitumor activity against hepatocellular carcinoma alone and in combination with sorafenib Cancer Research. 74: 815-815. DOI: 10.1158/1538-7445.Am2014-815  0.411
2014 Burkhart C, Kohrn R, Walker B, Meyer D, Gurova K, Gudkov A. Abstract 800: Synergistic effects of CBL0137 and gemcitabine against non-small cell lung and pancreatic cancer xenografts Cancer Research. 74: 800-800. DOI: 10.1158/1538-7445.Am2014-800  0.398
2014 Haber M, Murray J, Gamble L, Carnegie-Clark A, Webber H, Ruhle M, Carter D, Oberthur A, Fischer M, Ziegler D, Marshall G, Gurova K, Burkhart C, Purmal A, Gudkov A, et al. 422 CBL0137, a novel NFkB suppressor and p53 activator, is highly effective in pre-clinical models of neuroblastoma European Journal of Cancer. 50: 135. DOI: 10.1016/S0959-8049(14)70548-9  0.339
2013 Leontieva OV, Novototskaya LR, Paszkiewicz GM, Komarova EA, Gudkov AV, Blagosklonny MV. Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biology & Therapy. 14: 1182-8. PMID 24184801 DOI: 10.4161/Cbt.26947  0.379
2013 Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, ... ... Gudkov AV, et al. A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion. Cell Reports. 5: 493-507. PMID 24139804 DOI: 10.1016/J.Celrep.2013.09.015  0.356
2013 Burkhart CA, Haber M, Norris MD, Gudkov AV, Nikiforov MA. Cell-based methods for the identification of MYC-inhibitory small molecules. Methods in Molecular Biology (Clifton, N.J.). 1012: 255-64. PMID 24006071 DOI: 10.1007/978-1-62703-429-6_18  0.355
2013 Gudkov AV, Komarova EA. ATM is activated in blood monocytes after tumor radiation. Oncotarget. 4: 1125. PMID 23945353 DOI: 10.18632/Oncotarget.1286  0.378
2013 Tukhvatulin AI, Gitlin II, Shcheblyakov DV, Artemicheva NM, Burdelya LG, Shmarov MM, Naroditsky BS, Gudkov AV, Gintsburg AL, Logunov DY. Combined stimulation of Toll-like receptor 5 and NOD1 strongly potentiates activity of NF-κB, resulting in enhanced innate immune reactions and resistance to Salmonella enterica serovar Typhimurium infection. Infection and Immunity. 81: 3855-64. PMID 23897616 DOI: 10.1128/Iai.00525-13  0.314
2013 Burdelya LG, Brackett CM, Kojouharov B, Gitlin II, Leonova KI, Gleiberman AS, Aygun-Sunar S, Veith J, Johnson C, Haderski GJ, Stanhope-Baker P, Allamaneni S, Skitzki J, Zeng M, Martsen E, ... ... Gudkov AV, et al. Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. Proceedings of the National Academy of Sciences of the United States of America. 110: E1857-66. PMID 23630282 DOI: 10.1073/Pnas.1222805110  0.369
2013 Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proceedings of the National Academy of Sciences of the United States of America. 110: E89-98. PMID 23236145 DOI: 10.1073/Pnas.1216922110  0.401
2013 Leonova K, Gudkov A. Abstract PR02: “Guardians of repeats”: Novel and significant relationship of p53 and interferon Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Pr02  0.419
2013 Carter DR, Cheung BB, Liu T, Au C, Norris MD, Haber M, Murray J, Gurova KV, Gudkov AV, Marshall GM. Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation. Cancer Research. 73: 5043-5043. DOI: 10.1158/1538-7445.Am2013-5043  0.458
2013 Komarov A, Makhanov M, Komarova E, Novototzkaja L, Yeluashvili M, Suchkov D, Bonneau K, Tedesco D, Frangou CG, Diehl P, Deng D, Hyder K, Komarov P, Gudkov A, Chenchik A. Abstract 3160: Open-source RNAi genetic screen platform: discovery of drug targets in cancer cell models. Cancer Research. 73: 3160-3160. DOI: 10.1158/1538-7445.Am2013-3160  0.356
2013 Haber M, Murray J, Carnegie-Clark A, Webber H, Marshall GM, Gurova KV, Burkhart CA, Purmal A, Gudkov AV, Norris MD. Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma. Cancer Research. 73: 2759-2759. DOI: 10.1158/1538-7445.Am2013-2759  0.428
2013 Natarajan V, Komarov AP, Chenchik A, Gudkov AV. Abstract A30: NF-kB activating peptides identified in genetic screen cooperate with Ras transformation by suppression of p53 linking inflammation to carcinogenesis Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-A30  0.405
2012 Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 19392-6. PMID 23129611 DOI: 10.1073/Pnas.1217211109  0.384
2012 Ding X, Bian G, Leigh ND, Qiu J, McCarthy PL, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X. A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease. Journal of Immunology (Baltimore, Md. : 1950). 189: 4719-27. PMID 23045613 DOI: 10.4049/Jimmunol.1201206  0.339
2012 Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP. Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription. Proceedings of the National Academy of Sciences of the United States of America. 109: E2457-65. PMID 22895791 DOI: 10.1073/Pnas.1206274109  0.363
2012 Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 109: 13314-8. PMID 22847439 DOI: 10.1073/Pnas.1205690109  0.435
2012 Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV. Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice. Cancer Prevention Research (Philadelphia, Pa.). 5: 1025-35. PMID 22689915 DOI: 10.1158/1940-6207.Capr-11-0529  0.429
2012 Shakhov AN, Singh VK, Bone F, Cheney A, Kononov Y, Krasnov P, Bratanova-Toshkova TK, Shakhova VV, Young J, Weil MM, Panoskaltsis-Mortari A, Orschell CM, Baker PS, Gudkov A, Feinstein E. Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2). Plos One. 7: e33044. PMID 22479357 DOI: 10.1371/Journal.Pone.0033044  0.327
2012 Burdelya L, Leonova K, Gitlin I, Kojouharov B, Aygun-Sunar S, Veith J, Johnson C, Gleiberman A, Haderski G, Allamaneni S, Skitzki J, Stanhope-Baker P, Scheblyakov D, Logunov D, Narodisky B, ... Gudkov A, et al. Abstract 4398: Liver is a major primary target for the Toll-like receptor-5 agonist CBLB502 providing radioprotective, antimicrobial and antitumor responses Cancer Research. 72: 4398-4398. DOI: 10.1158/1538-7445.Am2012-4398  0.379
2012 Leonova K, Lipchick B, Brodsky L, Komarova E, Gudkov AV. Abstract 2959: p53 as a guardian of genomic junk: A novel role for p53 in epigenetic silencing of retroelements Cancer Research. 72: 2959-2959. DOI: 10.1158/1538-7445.Am2012-2959  0.441
2012 Huynh T, Tivnan A, Munoz M, Cheung L, Vishvanath A, Flemming C, Watt F, Burkhart C, Gudkov A, Fletcher J, Henderson M, Norris M, Haber M. Abstract 1834: Targeting ABC transporters in cancer through small molecule inhibitors Cancer Research. 72: 1834-1834. DOI: 10.1158/1538-7445.Am2012-1834  0.385
2011 Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP. Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. Oncotarget. 2: 1279-90. PMID 22249125 DOI: 10.18632/Oncotarget.411  0.355
2011 Leontieva OV, Demidenko ZN, Gudkov AV, Blagosklonny MV. Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin. Plos One. 6: e26126. PMID 22022534 DOI: 10.1371/Journal.Pone.0026126  0.403
2011 Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, ... Gudkov AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Science Translational Medicine. 3: 95ra74. PMID 21832239 DOI: 10.1126/Scitranslmed.3002530  0.442
2011 Gudkov AV, Gurova KV, Komarova EA. Inflammation and p53: A Tale of Two Stresses. Genes & Cancer. 2: 503-16. PMID 21779518 DOI: 10.1177/1947601911409747  0.421
2011 Jegede O, Khodyakova A, Chernov M, Weber J, Menéndez-Arias L, Gudkov A, Quiñones-Mateu ME. Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system. Antiviral Research. 91: 94-8. PMID 21600931 DOI: 10.1016/J.Antiviral.2011.05.004  0.314
2011 Lee MH, Jothi M, Gudkov AV, Mal AK. Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state. Cancer Research. 71: 3921-31. PMID 21493592 DOI: 10.1158/0008-5472.Can-10-3358  0.368
2011 Neznanov N, Komarov AP, Neznanova L, Stanhope-Baker P, Gudkov AV. Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib. Oncotarget. 2: 209-21. PMID 21444945 DOI: 10.18632/Oncotarget.246  0.393
2011 Tukhvatulin AI, Logunov DY, Gitlin II, Shmarov MM, Kudan PV, Adzhieva AA, Moroz AF, Kostyukova NN, Burdelya LG, Naroditsky BS, Gintsburg AL, Gudkov AV. A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB. Acta Naturae. 3: 77-84. DOI: 10.32607/20758251-2011-3-1-77-84  0.316
2011 Burdelya L, Leonova K, Kojouharov B, Veith J, Aygun-Sunar S, Gitlin I, Allamaneni S, Gleiberman A, Gudkov A. Abstract A63: TLR5 agonist CBLB502 protects mice from Fas-mediated liver damage without protecting tumors Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-A63  0.343
2011 Burdelya L, Gleiberman A, Gitlin I, Aygun-Sunar S, Rustum Y, Gudkov AV. Abstract LB-160: Dual application of TLR5 agonist in cancer treatment: A single agent combines supporting care and antitumor activities Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-160  0.382
2011 Xue C, Cheung L, Norris MD, Haber M, Burkhart C, Fedtsova N, Gudkov A, Makarov SS. Abstract 617: Small molecule that simultaneously inhibits Myc oncoprotein and activates HIF1A Cancer Research. 71: 617-617. DOI: 10.1158/1538-7445.Am2011-617  0.393
2010 Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle (Georgetown, Tex.). 9: 4323-7. PMID 21051933 DOI: 10.4161/Cc.9.21.13584  0.378
2010 Gasparian AV, Neznanov N, Jha S, Galkin O, Moran JJ, Gudkov AV, Gurova KV, Komar AA. Inhibition of encephalomyocarditis virus and poliovirus replication by quinacrine: implications for the design and discovery of novel antiviral drugs. Journal of Virology. 84: 9390-7. PMID 20631142 DOI: 10.1128/Jvi.02569-09  0.319
2010 Gudkov AV, Komarova EA. Pathologies associated with the p53 response. Cold Spring Harbor Perspectives in Biology. 2: a001180. PMID 20595398 DOI: 10.1101/Cshperspect.A001180  0.393
2010 Gudkov AV, Komarova EA. Radioprotection: smart games with death. The Journal of Clinical Investigation. 120: 2270-3. PMID 20577043 DOI: 10.1172/Jci43794  0.427
2010 Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proceedings of the National Academy of Sciences of the United States of America. 107: 9660-4. PMID 20457898 DOI: 10.1073/Pnas.1002298107  0.409
2010 Leonova KI, Shneyder J, Antoch MP, Toshkov IA, Novototskaya LR, Komarov PG, Komarova EA, Gudkov AV. A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice. Cell Cycle (Georgetown, Tex.). 9: 1434-43. PMID 20404530 DOI: 10.4161/Cc.9.7.11508  0.407
2010 Lu T, Jackson MW, Wang B, Yang M, Chance MR, Miyagi M, Gudkov AV, Stark GR. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proceedings of the National Academy of Sciences of the United States of America. 107: 46-51. PMID 20080798 DOI: 10.1073/Pnas.0912493107  0.364
2010 Kelly RM, Goren EM, Taylor PA, Mueller SN, Stefanski HE, Osborn MJ, Scott HS, Komarova EA, Gudkov AV, Holländer GA, Blazar BR. Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. Blood. 115: 1088-97. PMID 19965631 DOI: 10.1182/Blood-2009-05-223198  0.349
2010 Gurova K, Gudkov AV. Abstract SY18-02: Targeting transcriptional regulators for simultaneous modulation of p53 and NF-κB in cancer treatment Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Sy18-02  0.458
2010 Saito NG, Commane M, Greene KF, Novototskaya LR, Purmal AA, Wang Z, Gurova KV, Gudkov AV. Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-166  0.372
2009 Narizhneva NV, Tararova ND, Ryabokon P, Shyshynova I, Prokvolit A, Komarov PG, Purmal AA, Gudkov AV, Gurova KV. Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer. Cell Cycle (Georgetown, Tex.). 8: 4155-67. PMID 19946220 DOI: 10.4161/Cc.8.24.10316  0.359
2009 Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle (Georgetown, Tex.). 8: 4112-8. PMID 19946210 DOI: 10.4161/Cc.8.24.10215  0.345
2009 Neznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, Almasan A, Fairchild RL, Gudkov AV. Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. Cell Cycle (Georgetown, Tex.). 8: 3960-70. PMID 19901558 DOI: 10.4161/Cc.8.23.10179  0.397
2009 Korotchkina LG, Demidenko ZN, Gudkov AV, Blagosklonny MV. Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A. Cell Cycle (Georgetown, Tex.). 8: 3777-81. PMID 19855165 DOI: 10.4161/Cc.8.22.10121  0.38
2009 Lu T, Jackson MW, Singhi AD, Kandel ES, Yang M, Zhang Y, Gudkov AV, Stark GR. Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. Proceedings of the National Academy of Sciences of the United States of America. 106: 16339-44. PMID 19805303 DOI: 10.1073/Pnas.0908560106  0.365
2009 Burkhart CA, Watt F, Murray J, Pajic M, Prokvolit A, Xue C, Flemming C, Smith J, Purmal A, Isachenko N, Komarov PG, Gurova KV, Sartorelli AC, Marshall GM, Norris MD, ... Gudkov AV, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Research. 69: 6573-80. PMID 19654298 DOI: 10.1158/0008-5472.Can-09-1075  0.4
2009 Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, Gurova KV. 9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways Oncogene. 28: 1151-1161. PMID 19137016 DOI: 10.1038/Onc.2008.460  0.429
2009 Lu T, Jackson MW, Wang B, Yang M, Chance MR, Miyagi M, Gudkov AV, Stark GR. Regulation of NF κB by NSD1/FBXL11-dependent reversible lysine methylation of p65 Cytokine. 48: 19-20. DOI: 10.1016/J.Cyto.2009.07.079  0.327
2008 Komarov AP, Rokhlin OW, Yu CA, Gudkov AV. Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 14453-8. PMID 18796602 DOI: 10.1073/Pnas.0807549105  0.333
2008 Kravchenko JE, Ilyinskaya GV, Komarov PG, Agapova LS, Kochetkov DV, Strom E, Frolova EI, Kovriga I, Gudkov AV, Feinstein E, Chumakov PM. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proceedings of the National Academy of Sciences of the United States of America. 105: 6302-7. PMID 18424558 DOI: 10.1073/Pnas.0802091105  0.439
2008 Logunov DY, Scheblyakov DV, Zubkova OV, Shmarov MM, Rakovskaya IV, Gurova KV, Tararova ND, Burdelya LG, Naroditsky BS, Ginzburg AL, Gudkov AV. Mycoplasma infection suppresses p53, activates NF-κB and cooperates with oncogenic Ras in rodent fibroblast transformation Oncogene. 27: 4521-4531. PMID 18408766 DOI: 10.1038/Onc.2008.103  0.43
2008 Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (New York, N.Y.). 320: 226-30. PMID 18403709 DOI: 10.1126/Science.1154986  0.364
2008 Neznanov N, Dragunsky EM, Chumakov KM, Neznanova L, Wek RC, Gudkov AV, Banerjee AK. Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. Plos One. 3: e1887. PMID 18382670 DOI: 10.1371/Journal.Pone.0001887  0.301
2008 Neznanov N, Kondratova A, Chumakov KM, Neznanova L, Kondratov R, Banerjee AK, Gudkov AV. Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. Dna and Cell Biology. 27: 191-8. PMID 18067462 DOI: 10.1089/Dna.2007.0682  0.369
2008 Mao H, Thakur CS, Chattopadhyay S, Silverman RH, Gudkov A, Banerjee AK. Inhibition of human parainfluenza virus type 3 infection by novel small molecules. Antiviral Research. 77: 83-94. PMID 17964670 DOI: 10.1016/J.Antiviral.2007.09.001  0.314
2008 Shcheblyakov DV, Logunov DY, Zubkova OV, Shmarov MM, Rakovskaya IV, Naroditskii BS, Gintsburg AL, Gudkov AV. Mycoplasma infection with M. Arginini results in NF-κB constitutive activation and inhibition of apoptosis in cells expressing toll-like receptors TLR2/6 Molecular Genetics Microbiology and Virology. 23: 163-167. DOI: 10.3103/S0891416808040022  0.378
2008 Burdelya LG, Gupta D, Gleiberman AS, Aarun-Sunar S, Gudkov AV. Selective protection of normal tissues from radiation damage by activation of Toll-like receptor 5 signaling Radioprotection. 43. DOI: 10.1051/Radiopro:2008753  0.44
2007 Xue C, Haber M, Flemming C, Marshall GM, Lock RB, MacKenzie KL, Gurova KV, Norris MD, Gudkov AV. p53 determines multidrug sensitivity of childhood neuroblastoma. Cancer Research. 67: 10351-60. PMID 17974978 DOI: 10.1158/0008-5472.Can-06-4345  0.445
2007 Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas MS, Gudkov AV, Prochownik EV, Nikiforov MA. c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle. Oncogene. 27: 1905-15. PMID 17906696 DOI: 10.1038/Sj.Onc.1210823  0.4
2007 Gorbachev AV, Gasparian AV, Gurova KV, Gudkov AV, Fairchild RL. Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation. European Journal of Immunology. 37: 2257-67. PMID 17634953 DOI: 10.1002/Eji.200636708  0.331
2007 Gudkov AV, Komarova EA. Dangerous habits of a security guard: the two faces of p53 as a drug target. Human Molecular Genetics. 16: R67-72. PMID 17613549 DOI: 10.1093/Hmg/Ddm052  0.423
2007 Rossi SW, Jeker LT, Ueno T, Kuse S, Keller MP, Zuklys S, Gudkov AV, Takahama Y, Krenger W, Blazar BR, Holländer GA. Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood. 109: 3803-11. PMID 17213286 DOI: 10.1182/Blood-2006-10-049767  0.38
2006 Burdelya LG, Komarova EA, Hill JE, Browder T, Tararova ND, Mavrakis L, DiCorleto PE, Folkman J, Gudkov AV. Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. Cancer Research. 66: 9356-61. PMID 17018587 DOI: 10.1158/0008-5472.Can-06-1223  0.436
2006 Chikamori K, Hill JE, Grabowski DR, Zarkhin E, Grozav AG, Vaziri SA, Wang J, Gudkov AV, Rybicki LR, Bukowski RM, Yen A, Tanimoto M, Ganapathi MK, Ganapathi R. Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest. Leukemia. 20: 1809-18. PMID 16932348 DOI: 10.1038/Sj.Leu.2404351  0.393
2006 Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova I, Bosykh DA, Burdelya LG, Macklis RM, Skaliter R, Komarova EA, Gudkov AV. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature Chemical Biology. 2: 474-9. PMID 16862141 DOI: 10.1038/Nchembio809  0.413
2006 Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW. Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Research. 66: 3169-76. PMID 16540668 DOI: 10.1158/0008-5472.Can-05-3832  0.464
2006 Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes & Development. 20: 236-52. PMID 16418486 DOI: 10.1101/Gad.1372606  0.771
2006 Kichina JV, Zeremski M, Aris L, Gurova KV, Walker E, Franks R, Nikitin AY, Kiyokawa H, Gudkov AV. Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas Oncogene. 25: 857-866. PMID 16170338 DOI: 10.1038/Sj.Onc.1209118  0.375
2005 Vaziri SA, Hill J, Chikamori K, Grabowski DR, Takigawa N, Chawla-Sarkar M, Rybicki LR, Gudkov AV, Mekhail T, Bukowski RM, Ganapathi MK, Ganapathi R. Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin. Molecular Cancer Therapeutics. 4: 1880-90. PMID 16373703 DOI: 10.1158/1535-7163.Mct-05-0222  0.407
2005 Neznanov N, Neznanova L, Angres B, Gudkov AV. Serologically defined colon cancer antigen 3 is necessary for the presentation of TNF receptor 1 on cell surface. Dna and Cell Biology. 24: 777-85. PMID 16332174 DOI: 10.1089/Dna.2005.24.777  0.394
2005 Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E, Khodyakova AV, Ganapathi R, Ganapathi M, Tararova ND, Bosykh D, Lvovskiy D, Webb TR, Stark GR, Gudkov AV. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proceedings of the National Academy of Sciences of the United States of America. 102: 17448-53. PMID 16287968 DOI: 10.1073/Pnas.0508888102  0.455
2005 Kondratova AA, Neznanov N, Kondratov RV, Gudkov AV. Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division. Cell Cycle (Georgetown, Tex.). 4: 1403-10. PMID 16138011 DOI: 10.4161/Cc.4.10.2041  0.335
2005 Marques JT, Rebouillat D, Ramana CV, Murakami J, Hill JE, Gudkov A, Silverman RH, Stark GR, Williams BR. Down-regulation of p53 by double-stranded RNA modulates the antiviral response. Journal of Virology. 79: 11105-14. PMID 16103161 DOI: 10.1128/Jvi.79.17.11105-11114.2005  0.409
2005 Gudkov AV, Komarova EA. Prospective therapeutic applications of p53 inhibitors. Biochemical and Biophysical Research Communications. 331: 726-36. PMID 15865929 DOI: 10.1016/J.Bbrc.2005.03.153  0.427
2005 Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG, Brennan ML, Golovkina TV, Rokhlin OW, Kuprash DV, Nedospasov SA, Hazen SL, Feinstein E, Gudkov AV. p53 is a suppressor of inflammatory response in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1030-2. PMID 15811878 DOI: 10.1096/Fj.04-3213Fje  0.453
2005 Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, Antoch MP. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proceedings of the National Academy of Sciences of the United States of America. 102: 3407-12. PMID 15689397 DOI: 10.1073/Pnas.0409897102  0.335
2004 Gudkov AV. Cancer drug discovery: the wisdom of imprecision. Nature Medicine. 10: 1298-9. PMID 15580251 DOI: 10.1038/Nm1204-1298  0.304
2004 Tarunina M, Alger L, Chu G, Munger K, Gudkov A, Jat PS. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Molecular and Cellular Biology. 24: 10792-801. PMID 15572682 DOI: 10.1128/Mcb.24.24.10792-10801.2004  0.467
2004 Singhi AD, Kondratov RV, Neznanov N, Chernov MV, Gudkov AV. Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection. Proceedings of the National Academy of Sciences of the United States of America. 101: 9327-32. PMID 15187233 DOI: 10.1073/Pnas.0403080101  0.341
2004 Lu T, Burdelya LG, Swiatkowski SM, Boiko AD, Howe PH, Stark GR, Gudkov AV. Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 7112-7. PMID 15118089 DOI: 10.1073/Pnas.0402048101  0.763
2004 Neznanov N, Neznanova L, Kondratov RV, O'Rourke DM, Ullrich A, Gudkov AV. The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha. Dna and Cell Biology. 23: 175-82. PMID 15068587 DOI: 10.1089/104454904322964779  0.373
2004 Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR, Gudkov AV. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene. 23: 3265-71. PMID 15064735 DOI: 10.1038/Sj.Onc.1207494  0.372
2004 Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Research. 64: 1951-8. PMID 15026329 DOI: 10.1158/0008-5472.Can-03-1541  0.423
2004 Vaziri S, Mekhail T, Hill J, Gudkov A, Ganapathi M, Bukowski R, Ganapathi R. 213 von Hippel-Lindau (VHL) and p53 dependent cytotoxic effects of the proteasome inhibitor bortezomib (PS) in human renal cancer cells European Journal of Cancer Supplements. 2: 65-66. DOI: 10.1016/S1359-6349(04)80221-0  0.359
2004 Takigawa N, Vaziri S, Mekhail T, Grabowski D, Chikamori K, Hill J, Gudkov A, Bukowski R, Ganapathi R, Ganapathi M. 203 Modulation of DNA damage induced apoptosis by the proteasome inhibitor bortezomib (PS) in human colorectal and non-small cell lung cancer cells is p53-dependent and NK-kB-independent European Journal of Cancer Supplements. 2: 63. DOI: 10.1016/S1359-6349(04)80211-8  0.374
2003 Gudkov A. Microarray analysis of p53-mediated transcription: multi-thousand piece puzzle or invitation to collective thinking. Cancer Biology & Therapy. 2: 444-5. PMID 14508118 DOI: 10.4161/Cbt.2.4.480  0.376
2003 Kondratov RV, Chernov MV, Kondratova AA, Gorbacheva VY, Gudkov AV, Antoch MP. BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes & Development. 17: 1921-32. PMID 12897057 DOI: 10.1101/Gad.1099503  0.311
2003 Kichina JV, Rauth S, Das Gupta TK, Gudkov AV. Melanoma cells can tolerate high levels of transcriptionally active endogenous p53 but are sensitive to retrovirus-transduced p53. Oncogene. 22: 4911-7. PMID 12894234 DOI: 10.1038/Sj.Onc.1206741  0.401
2003 Gudkov A, Komarova E. Isolation of p53 inhibitors by screening chemical libraries in cell-based readout system. Methods in Molecular Biology (Clifton, N.J.). 223: 635-48. PMID 12777754 DOI: 10.1385/1-59259-329-1:635  0.321
2003 Komarova EA, Neznanov N, Komarov PG, Chernov MV, Wang K, Gudkov AV. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. The Journal of Biological Chemistry. 278: 15465-8. PMID 12637507 DOI: 10.1074/Jbc.C300011200  0.393
2003 Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nature Reviews. Cancer. 3: 117-29. PMID 12563311 DOI: 10.1038/Nrc992  0.349
2003 Gurova KV, Gudkov AV. Paradoxical role of apoptosis in tumor progression. Journal of Cellular Biochemistry. 88: 128-37. PMID 12461782 DOI: 10.1002/Jcb.10382  0.386
2003 Neznanov N, Neznanova L, Kondratov RV, Burdelya L, Kandel ES, O'Rourke DM, Ullrich A, Gudkov AV. Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B. The Journal of Biological Chemistry. 278: 3809-15. PMID 12446684 DOI: 10.1074/Jbc.M210698200  0.423
2002 Zou X, Ray D, Aziyu A, Christov K, Boiko AD, Gudkov AV, Kiyokawa H. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes & Development. 16: 2923-34. PMID 12435633 DOI: 10.1101/Gad.1033002  0.773
2002 Gudkov AV. Converting p53 from a killer into a healer Nature Medicine. 8: 1196-1198. PMID 12411937 DOI: 10.1038/Nm1102-1196  0.348
2002 Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV, Rotter V. Falkor, a novel cell growth regulator isolated by a functional genetic screen. Oncogene. 21: 6713-21. PMID 12360397 DOI: 10.1038/Sj.Onc.1205867  0.351
2002 Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene. 21: 6017-31. PMID 12203114 DOI: 10.1038/Sj.Onc.1205877  0.376
2002 Gurova KV, Kwek SS, Koman IE, Komarov AP, Kandel E, Nikiforov MA, Gudkov AV. Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor. Cancer Biology & Therapy. 1: 39-44. PMID 12170763 DOI: 10.4161/Cbt.1.1.39  0.43
2002 Rokhlin OW, Glover RA, Taghiyev AF, Guseva NV, Seftor RE, Shyshynova I, Gudkov AV, Cohen MB. Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription. The Journal of Biological Chemistry. 277: 33213-9. PMID 12091392 DOI: 10.1074/Jbc.M204612200  0.43
2002 Bacus SS, Altomare DA, Lyass L, Chin DM, Farrell MP, Gurova K, Gudkov A, Testa JR. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene. 21: 3532-40. PMID 12032855 DOI: 10.1038/Sj.Onc.1205438  0.361
2002 Gurova KV, Roklin OW, Krivokrysenko VI, Chumakov PM, Cohen MB, Feinstein E, Gudkov AV. Expression of prostate specific antigen (PSA) is negatively regulated by p53. Oncogene. 21: 153-7. PMID 11791186 DOI: 10.1038/Sj.Onc.1205001  0.365
2001 Neznanov N, Gudkov A. Pretreatment of the Cells With Brefeldin A and Cycloheximide Differently Regulates Fas and TNF Stimulated Apoptosis. Thescientificworldjournal. 1: 40. PMID 30147489 DOI: 10.1100/Tsw.2001.146  0.348
2001 Garkavtsev IV, Kley N, Grigorian IA, Gudkov AV. The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control. Oncogene. 20: 8276-80. PMID 11781842 DOI: 10.1038/Sj.Onc.1205120  0.414
2001 Kondratov RV, Komarov PG, Becker Y, Ewenson A, Gudkov AV. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 98: 14078-83. PMID 11707575 DOI: 10.1073/Pnas.241314798  0.354
2001 Neznanov N, Kondratova A, Chumakov KM, Angres B, Zhumabayeva B, Agol VI, Gudkov AV. Poliovirus protein 3A inhibits tumor necrosis factor (TNF)-induced apoptosis by eliminating the TNF receptor from the cell surface. Journal of Virology. 75: 10409-20. PMID 11581409 DOI: 10.1128/Jvi.75.21.10409-10420.2001  0.358
2001 Komarova EA, Gudkov AV. Chemoprotection from p53-dependent apoptosis: Potential clinical applications of the p53 inhibitors Biochemical Pharmacology. 62: 657-667. PMID 11556286 DOI: 10.1016/S0006-2952(01)00733-X  0.414
2001 Kwek SS, Derry J, Tyner AL, Shen Z, Gudkov AV. Functional analysis and intracellular localization of p53 modified by SUMO-1. Oncogene. 20: 2587-99. PMID 11420669 DOI: 10.1038/Sj.Onc.1204362  0.383
2001 Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Sharov AA, Komarov PG, Maurer M, Gudkov AV, Gilchrest BA. p53 Involvement in the control of murine hair follicle regression. The American Journal of Pathology. 158: 1913-9. PMID 11395365 DOI: 10.1016/S0002-9440(10)64659-7  0.405
2001 Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, Keyomarsi K, Yarden Y, Seger R. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene. 20: 147-55. PMID 11313944 DOI: 10.1038/Sj.Onc.1204062  0.415
2000 Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. The Journal of Biological Chemistry. 276: 8734-9. PMID 11118440 DOI: 10.1074/Jbc.M007664200  0.421
2000 Komarova EA, Christov K, Faerman AI, Gudkov AV. Different impact of p53 and p21 on the radiation response of mouse tissues Oncogene. 19: 3791-3798. PMID 10949934 DOI: 10.1038/Sj.Onc.1203717  0.39
2000 Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA. Conformational activation of radixin by G13 protein alpha subunit. The Journal of Biological Chemistry. 275: 26206-12. PMID 10816569 DOI: 10.1074/Jbc.M001863200  0.307
2000 Rokhlin OW, Gudkov AV, Kwek S, Glover RA, Gewies AS, Cohen MB. p53 is involved in tumor necrosis factor-alpha-induced apoptosis in the human prostatic carcinoma cell line LNCaP. Oncogene. 19: 1959-68. PMID 10773886 DOI: 10.1038/Sj.Onc.1203453  0.36
2000 Komarova EA, Gudkov AV. Suppression of p53: A New Approach to Overcome Side Effects of Antitumor Therapy Biochemistry (Moscow). 65: 41-48. PMID 10702639  0.326
1999 Mittelman JM, Gudkov AV. Generation of p53 Suppressor Peptide from the Fragment of p53 Protein Somatic Cell and Molecular Genetics. 25: 115-128. PMID 11441532 DOI: 10.1023/A:1018822121890  0.39
1999 Zeremski M, Hill JE, Kwek SS, Grigorian IA, Gurova KV, Garkavtsev IV, Diatchenko L, Koonin EV, Gudkov AV. Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. The Journal of Biological Chemistry. 274: 32172-81. PMID 10542254 DOI: 10.1074/Jbc.274.45.32172  0.377
1999 Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (New York, N.Y.). 285: 1733-7. PMID 10481009 DOI: 10.1126/Science.285.5434.1733  0.431
1999 Stark GR, Gudkov AV. Forward genetics in mammalian cells: Functional approaches to gene discovery Human Molecular Genetics. 8: 1925-1938. PMID 10469846 DOI: 10.1093/Hmg/8.10.1925  0.33
1998 Komarova EA, Diatchenko L, Rokhlin OW, Hill JE, Wang ZJ, Krivokrysenko VI, Feinstein E, Gudkov AV. Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. Oncogene. 17: 1089-96. PMID 9764819 DOI: 10.1038/Sj.Onc.1202303  0.474
1998 Axenovich SA, Kazarov AR, Boiko AD, Armin G, Roninson IB, Gudkov AV. Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Research. 58: 3423-8. PMID 9699675  0.721
1998 Deichman GJ, Matveeva VA, Kashkina LM, Dyakova NA, Uvarova EN, Nikiforov MA, Gudkov AV. Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes. International Journal of Cancer. 75: 277-83. PMID 9462719 DOI: 10.1002/(Sici)1097-0215(19980119)75:2<277::Aid-Ijc17>3.0.Co;2-A  0.402
1998 Nikiforov MA, Kwek SS, Mehta R, Artwohl JE, Lowe SW, Gupta TD, Deichman GI, Gudkov AV. Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence. Oncogene. 15: 3007-12. PMID 9444949 DOI: 10.1038/Sj.Onc.1201723  0.435
1998 Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. Nature. 391: 295-8. PMID 9440695 DOI: 10.1038/34675  0.441
1998 Bacus S, Kiffmeyer B, Gudkov A, Keyomarsi K. Heregulin and doxorubicin activate a p53 dependent pathway in cancer cells whereas taxol depends on activation of the MAP kinase pathway European Journal of Cancer. 34: S30. DOI: 10.1016/S0959-8049(98)80124-X  0.356
1997 Komarova EA, Gudkov AV. Could p53 be a target for therapeutic suppression? Seminars in Cancer Biology. 8: 389-400. PMID 10101804 DOI: 10.1006/Scbi.1998.0101  0.428
1997 Zeremski M, Horrigan SK, Grigorian IA, Westbrook CA, Gudkov AV. Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34. Somatic Cell and Molecular Genetics. 23: 233-6. PMID 9330636 DOI: 10.1007/Bf02721376  0.337
1997 Komarova EA, Chernov MV, Franks R, Wang K, Armin G, Zelnick CR, Chin DM, Bacus SS, Stark GR, Gudkov AV. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo Embo Journal. 16: 1391-1400. PMID 9135154 DOI: 10.1093/Emboj/16.6.1391  0.402
1996 Garkavtsev I, Kazarov A, Gudkov A, Riabowol K. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation. Nature Genetics. 14: 415-20. PMID 8944021 DOI: 10.1038/Ng1296-415  0.387
1996 Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, Kondratov R, Stark GR, Chumakov PM, Gudkov AV. Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains Proceedings of the National Academy of Sciences of the United States of America. 93: 10309-10314. PMID 8816796 DOI: 10.1073/Pnas.93.19.10309  0.404
1996 Norris MD, De Graaf D, Haber M, Kavallaris M, Madafiglio J, Gilbert J, Kwan E, Stewart BW, Mechetner EB, Gudkov AV, Roninson IB. Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. International Journal of Cancer. 65: 613-9. PMID 8598312 DOI: 10.1002/(Sici)1097-0215(19960301)65:5<613::Aid-Ijc10>3.0.Co;2-8  0.329
1994 Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proceedings of the National Academy of Sciences of the United States of America. 91: 3744-8. PMID 8170981 DOI: 10.1073/Pnas.91.9.3744  0.373
1993 Gudkov AV, Zelnick CR, Kazarov AR, Thimmapaya R, Suttle DP, Beck WT, Roninson IB. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proceedings of the National Academy of Sciences of the United States of America. 90: 3231-5. PMID 8386368 DOI: 10.1073/Pnas.90.8.3231  0.304
1991 Tikhonenko AT, Polotskaya AV, Vassetzky NS, Golovkina TV, Gudkov AV. Long terminal repeats of dwarf hamster endogenous retrovirus are highly diverged and do not maintain efficient transcription. Virology. 181: 367-70. PMID 1994585 DOI: 10.1016/0042-6822(91)90505-6  0.332
1987 Gudkov AV, Chernova OB, Kazarov AR, Kopnin BP. Cloning and characterization of DNA sequences amplified in multidrug-resistant Djungarian hamster and mouse cells Somatic Cell and Molecular Genetics. 13: 609-619. PMID 2823393 DOI: 10.1007/Bf01534481  0.326
1985 Gudkov AV, Massino JS, Chernova OB, Kopnin BP. Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs. Chromosoma. 92: 16-24. PMID 2988876 DOI: 10.1007/Bf00327241  0.314
1984 Polotskaya AV, Gudkov AV, Kopnin BP. Hyperproduction of a specific protein in cells resistant to colchicine and adriablastin Bulletin of Experimental Biology and Medicine. 96: 1304-1307. DOI: 10.1007/Bf00834822  0.303
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