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George J. Leslie, Ph.D. - Publications

Affiliations: 
2010 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Virology Biology, Microbiology Biology, Immunology
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Addison MM, Ellis GI, Leslie GJ, Zawadzky NB, Riley JL, Hoxie JA, Eisenlohr LC. HIV-1-Infected CD4 T Cells Present MHC Class II-Restricted Epitope via Endogenous Processing. Journal of Immunology (Baltimore, Md. : 1950). 209: 864-873. PMID 36130133 DOI: 10.4049/jimmunol.2200145  0.641
2022 Lawrence SP, Elser SE, Torben W, Blair RV, Pahar B, Aye PP, Schiro F, Szeltner D, Doyle-Meyers LA, Haggarty BS, Jordan APO, Romano J, Leslie GJ, Alvarez X, O'Connor DH, et al. A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection. Plos Pathogens. 18: e1010507. PMID 35714165 DOI: 10.1371/journal.ppat.1010507  0.577
2020 Maldini CR, Claiborne DT, Okawa K, Chen T, Dopkin DL, Shan X, Power KA, Trifonova RT, Krupp K, Phelps M, Vrbanac VD, Tanno S, Bateson T, Leslie GJ, Hoxie JA, et al. Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Nature Medicine. PMID 32868878 DOI: 10.1038/S41591-020-1039-5  0.667
2020 Schouest B, Leslie GJ, Hoxie JA, Maness NJ. Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant. Plos One. 15: e0225420. PMID 32764749 DOI: 10.1371/Journal.Pone.0225420  0.621
2016 Leslie GJ, Wang J, Richardson MW, Haggarty BS, Hua KL, Duong J, Secreto AJ, Jordon AP, Romano J, Kumar KE, DeClercq JJ, Gregory PD, June CH, Root MJ, Riley JL, et al. Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus. Plos Pathogens. 12: e1005983. PMID 27855210 DOI: 10.1371/Journal.Ppat.1005983  0.71
2016 Swanstrom AE, Haggarty B, Jordan AP, Romano J, Leslie GJ, Aye PP, Marx PA, Lackner AA, Del Prete GQ, Robinson JE, Betts MR, Montefiori DC, LaBranche CC, Hoxie JA. Derivation and characterization of a CD4-independent, non-CD4 tropic simian immunodeficiency virus. Journal of Virology. PMID 26937037 DOI: 10.1128/Jvi.02851-15  0.735
2016 Leslie GJ, Richardson M, Wang J, Gregory P, Riley J, Holmes M, Hoxie J. 427. In Vivo Inhibition of HIV-1 in NSG Mice After Transduction of Primary Human T Cells with CXCR4 Conjugated to an HR2 Peptide Molecular Therapy. 24: S169. DOI: 10.1016/S1525-0016(16)33236-1  0.697
2013 Bastian AR, Contarino M, Bailey LD, Aneja R, Moreira DRM, Freedman K, McFadden K, Duffy C, Emileh A, Leslie G, Jacobson JM, Hoxie JA, Chaiken I. Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions Retrovirology. 10. PMID 24330857 DOI: 10.1186/1742-4690-10-153  0.686
2011 Acharya P, Dogo-Isonagie C, LaLonde JM, Lam SN, Leslie GJ, Louder MK, Frye LL, Debnath AK, Greenwood JR, Luongo TS, Martin L, Watts KS, Hoxie JA, Mascola JR, Bewley CA, et al. Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. Acs Chemical Biology. 6: 1069-77. PMID 21793507 DOI: 10.1021/Cb200068B  0.702
2010 Del Prete GQ, Leslie GJ, Haggarty B, Jordan AP, Romano J, Hoxie JA. Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist. Journal of Virology. 84: 8777-89. PMID 20573813 DOI: 10.1128/Jvi.00333-10  0.772
2009 Del Prete GQ, Haggarty B, Leslie GJ, Jordan AP, Romano J, Wang N, Wang J, Holmes MC, Montefiori DC, Hoxie JA. Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4. Journal of Virology. 83: 9911-22. PMID 19605489 DOI: 10.1128/Jvi.00533-09  0.795
2009 Nolan KM, Del Prete GQ, Jordan AP, Haggarty B, Romano J, Leslie GJ, Hoxie JA. Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor. Journal of Virology. 83: 3798-809. PMID 19193800 DOI: 10.1128/Jvi.01751-08  0.747
2007 Laakso MM, Lee FH, Haggarty B, Agrawal C, Nolan KM, Biscone M, Romano J, Jordan AP, Leslie GJ, Meissner EG, Su L, Hoxie JA, Doms RW. V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies. Plos Pathogens. 3: e117. PMID 17722977 DOI: 10.1371/Journal.Ppat.0030117  0.804
2007 Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, Nolan KM, Leslie GJ, Jordan AP, Huang CC, Kwong PD, Doms RW, Hoxie JA. Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists. Journal of Virology. 81: 9956-66. PMID 17609282 DOI: 10.1128/Jvi.00385-07  0.766
2007 Pöhlmann S, Münch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, et al. A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. Virology. 360: 275-85. PMID 17126374 DOI: 10.1016/J.Virol.2006.10.020  0.576
2004 Pöhlmann S, Davis C, Meister S, Leslie GJ, Otto C, Reeves JD, Puffer BA, Papkalla A, Krumbiegel M, Marzi A, Lorenz S, Münch J, Doms RW, Kirchhoff F. Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors. Journal of Virology. 78: 3223-32. PMID 15016843 DOI: 10.1128/Jvi.78.7.3223-3232.2004  0.527
2003 Pöhlmann S, Zhang J, Baribaud F, Chen Z, Leslie GJ, Lin G, Granelli-Piperno A, Doms RW, Rice CM, McKeating JA. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. Journal of Virology. 77: 4070-80. PMID 12634366 DOI: 10.1128/Jvi.77.7.4070-4080.2003  0.704
2003 Lin G, Simmons G, Pöhlmann S, Baribaud F, Ni H, Leslie GJ, Haggarty BS, Bates P, Weissman D, Hoxie JA, Doms RW. Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR. Journal of Virology. 77: 1337-46. PMID 12502850 DOI: 10.1128/Jvi.77.2.1337-1346.2003  0.766
2002 Baribaud F, Pöhlmann S, Leslie G, Mortari F, Doms RW. Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells. Journal of Virology. 76: 9135-42. PMID 12186897 DOI: 10.1128/Jvi.76.18.9135-9142.2002  0.561
2002 Soilleux EJ, Morris LS, Leslie G, Chehimi J, Luo Q, Levroney E, Trowsdale J, Montaner LJ, Doms RW, Weissman D, Coleman N, Lee B. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. Journal of Leukocyte Biology. 71: 445-57. PMID 11867682 DOI: 10.1189/Jlb.71.3.445  0.382
2001 Lee B, Leslie G, Soilleux E, O'Doherty U, Baik S, Levroney E, Flummerfelt K, Swiggard W, Coleman N, Malim M, Doms RW. cis expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor Journal of Virology. 75: 12028-12038. PMID 11711593 DOI: 10.1128/Jvi.75.24.12028-12038.2001  0.561
2001 Pöhlmann S, Leslie GJ, Edwards TG, Macfarlan T, Reeves JD, Hiebenthal-Millow K, Kirchhoff F, Baribaud F, Doms RW. DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions. Journal of Virology. 75: 10523-6. PMID 11581425 DOI: 10.1128/Jvi.75.21.10523-10526.2001  0.566
2001 Baribaud F, Pöhlmann S, Sparwasser T, Kimata MT, Choi YK, Haggarty BS, Ahmad N, Macfarlan T, Edwards TG, Leslie GJ, Arnason J, Reinhart TA, Kimata JT, Littman DR, Hoxie JA, et al. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. Journal of Virology. 75: 10281-9. PMID 11581396 DOI: 10.1128/Jvi.75.21.10281-10289.2001  0.666
2001 Pöhlmann S, Baribaud F, Lee B, Leslie GJ, Sanchez MD, Hiebenthal-Millow K, Münch J, Kirchhoff F, Doms RW. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. Journal of Virology. 75: 4664-72. PMID 11312337 DOI: 10.1128/Jvi.75.10.4664-4672.2001  0.596
2001 Pöhlmann S, Soilleux EJ, Baribaud F, Leslie GJ, Morris LS, Trowsdale J, Lee B, Coleman N, Doms RW. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proceedings of the National Academy of Sciences of the United States of America. 98: 2670-5. PMID 11226297 DOI: 10.1073/Pnas.051631398  0.544
2000 Pöhlmann S, Lee B, Meister S, Krumbiegel M, Leslie G, Doms RW, Kirchhoff F. Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry. Journal of Virology. 74: 5075-82. PMID 10799581 DOI: 10.1128/Jvi.74.11.5075-5082.2000  0.473
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