Javier Egea - Publications

Affiliations: 
Pharmacology Universidad Autónoma de Madrid, Madrid, Comunidad de Madrid, Spain 
Area:
neuroprotection

105 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Palomino-Antolín A, Decouty-Pérez C, Farré-Alins V, Narros-Fernández P, Lopez-Rodriguez AB, Álvarez-Rubal M, Valencia I, López-Muñoz F, Ramos E, Cuadrado A, Casas AI, Romero A, Egea J. Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4. Antioxidants (Basel, Switzerland). 12. PMID 37760032 DOI: 10.3390/antiox12091729  0.479
2023 Rocchi D, González JF, Martín-Cámara O, Perrone MG, Miciaccia M, Scilimati A, Decouty-Pérez C, Parada E, Egea J, Menéndez JC. -Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity. Molecules (Basel, Switzerland). 28. PMID 37513247 DOI: 10.3390/molecules28145374  0.744
2022 Padín JF, Maroto M, Entrena JM, Egea J, Montell E, Vergés J, López MG, Cobos EJ, García AG. Small synthetic hyaluronan disaccharide BIS014 mitigates neuropathic pain in mice. The Journal of Pain. PMID 36087908 DOI: 10.1016/j.jpain.2022.07.014  0.773
2022 Casas AI, Hassan AA, Manz Q, Wiwie C, Kleikers P, Egea J, López MG, List M, Baumbach J, Schmidt HHHW. Un-biased housekeeping gene panel selection for high-validity gene expression analysis. Scientific Reports. 12: 12324. PMID 35853974 DOI: 10.1038/s41598-022-15989-8  0.654
2021 Farré-Alins V, Palomino-Antolín A, Narros-Fernández P, Lopez-Rodriguez AB, Decouty-Perez C, Muñoz-Montero A, Zamorano-Fernández J, Mansilla-Fernández B, Giner-García J, García-Feijoo P, Sáez-Alegre M, Palpán-Flores AJ, Roda-Frade JM, Carabias CS, Rosa JM, ... ... Egea J, et al. Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients. Biomedicines. 9. PMID 34070533 DOI: 10.3390/biomedicines9060599  0.704
2021 Rosa JM, Farre-Alins V, Ortega MC, Navarrete M, Lopez-Rodriguez AB, Palomino-Antolin A, Fernandez-Lopez E, Vila-Del Sol V, Decouty C, Narros-Fernandez P, Clemente D, Egea J. TLR4-pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury. British Journal of Pharmacology. PMID 33830504 DOI: 10.1111/bph.15488  0.596
2021 Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C. Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation. Journal of Medicinal Chemistry. PMID 33560845 DOI: 10.1021/acs.jmedchem.0c02145  0.609
2020 Farré-Alins V, Narros-Fernández P, Palomino-Antolín A, Decouty-Pérez C, Lopez-Rodriguez AB, Parada E, Muñoz-Montero A, Gómez-Rangel V, López-Muñoz F, Ramos E, González-Rodríguez Á, Gandía L, Romero A, Egea J. Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux. Antioxidants (Basel, Switzerland). 9. PMID 33353046 DOI: 10.3390/antiox9121299  0.788
2020 Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, ... ... Egea J, et al. Na controls hypoxic signalling by the mitochondrial respiratory chain. Nature. PMID 32728214 DOI: 10.1038/S41586-020-2551-Y  0.787
2019 Malek R, Arribas RL, Palominoantolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I, Diez-Iriepa D, Godyń J, Panek D, Malawska B, Gluch-Lutwin M, Mordyl B, ... ... Egea J, et al. New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition. Journal of Medicinal Chemistry. PMID 31724859 DOI: 10.1021/Acs.Jmedchem.9B00937  0.315
2019 Rubio-Navarro A, Vázquez-Carballo C, Guerrero-Hue M, García-Caballero C, Herencia C, Gutiérrez E, Yuste C, Sevillano Á, Praga M, Egea J, Cannata P, Cortegano I, de Andrés B, Gaspar ML, Cadenas S, et al. Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury. Frontiers in Pharmacology. 10: 740. PMID 31333462 DOI: 10.3389/Fphar.2019.00740  0.352
2019 Parada E, Casas AI, Palomino-Antolin A, Gómez-Rangel V, Rubio-Navarro A, Farré-Alins V, Narros-Fernandez P, Guerrero-Hue M, Moreno JA, Rosa JM, Roda JM, Hernández-García BJ, Egea J. Early TLR4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodents and human brain ischemia models. British Journal of Pharmacology. PMID 31074003 DOI: 10.1111/Bph.14703  0.78
2019 Guerrero-Hue M, García-Caballero C, Palomino-Antolín A, Rubio-Navarro A, Vázquez-Carballo C, Herencia C, Martín-Sanchez D, Farré-Alins V, Egea J, Cannata P, Praga M, Ortiz A, Egido J, Sanz AB, Moreno JA. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900077R. PMID 31034781 DOI: 10.1096/Fj.201900077R  0.384
2019 Ramos E, Palomino-Antolín A, Bartolini M, Iriepa I, Moraleda I, Diez-Iriepa D, Samadi A, Cortina CV, Chioua M, Egea J, Romero A, Marco-Contelles J. QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). 24. PMID 30999586 DOI: 10.3390/Molecules24081503  0.322
2019 Casas AI, Hassan AA, Larsen SJ, Gomez-Rangel V, Elbatreek M, Kleikers PWM, Guney E, Egea J, López MG, Baumbach J, Schmidt HHHW. From single drug targets to synergistic network pharmacology in ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894481 DOI: 10.1073/Pnas.1820799116  0.707
2019 Casas AI, Kleikers PW, Geuss E, Langhauser F, Adler T, Busch DH, Gailus-Durner V, de Angelis MH, Egea J, Lopez MG, Kleinschnitz C, Schmidt HH. Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke. The Journal of Clinical Investigation. 130. PMID 30882367 DOI: 10.1172/Jci124283  0.719
2018 Arribas RL, Romero A, Egea J, de Los Ríos C. Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases. British Journal of Pharmacology. PMID 29781146 DOI: 10.1111/Bph.14365  0.363
2018 Guerrero-Hue M, Palomino-Antolín A, García-Caballero C, Córdoba GM, Vázquez-Carballo C, Farré-Alins V, Rubio-Navarro A, Egea J, Parada E, Egido J, Moreno JA. FP231TREATMENT WITH CURCUMINE DECREASES RENAL DAMAGE ASSOCIATED WITH RHABDOMYOLYSIS - ACUTE KIDNEY INJURY Nephrology Dialysis Transplantation. 33: i108-i108. DOI: 10.1093/Ndt/Gfy104.Fp231  0.702
2018 Hernansanz-Agustín P, Ramos E, Villa-Piña T, Navarro E, Parada E, Moreno L, Izquierdo-Álvarez A, Oliva T, Cabrera-García JD, Cortés A, Tello D, Acín-Pérez R, Buendia I, Rodríguez-Aguilera JC, Navas P, ... ... Egea J, et al. Mitochondrial Na + import controls oxidative phosphorylation and hypoxic redox signaling Free Radical Biology and Medicine. 120: S29. DOI: 10.1016/J.Freeradbiomed.2018.04.103  0.79
2017 Rubio-Navarro A, Sanchez-Niño MD, Guerrero-Hue M, García-Caballero C, Gutiérrez E, Yuste C, Sevillano Á, Praga M, Egea J, Román E, Cannata P, Ortega R, Cortegano I, de Andrés B, Gaspar ML, et al. Podocytes are new cellular targets of hemoglobin-mediated renal damage. The Journal of Pathology. PMID 29205354 DOI: 10.1002/Path.5011  0.38
2017 Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, et al. Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Redox Biology. PMID 29107648 DOI: 10.1016/J.Redox.2017.10.001  0.714
2017 Casas AI, Geuss E, Kleikers PWM, Mencl S, Herrmann AM, Buendia I, Egea J, Meuth SG, Lopez MG, Kleinschnitz C, Schmidt HHHW. NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087944 DOI: 10.1073/Pnas.1705034114  0.722
2017 Bautista-Aguilera ÓM, Hagenow S, Palomino-Antolin A, Farré-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janočková J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martínez A, ... ... Egea J, et al. Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases. Angewandte Chemie (International Ed. in English). PMID 28861918 DOI: 10.1002/Anie.201706072  0.366
2017 Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, et al. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13: 94-162. PMID 28577489 DOI: 10.1016/J.Redox.2017.05.007  0.762
2017 Hernansanz-Agustín P, Ramos E, Navarro E, Parada E, Sánchez-López N, Peláez-Aguado L, Cabrera-García JD, Tello D, Buendia I, Marina A, Egea J, López MG, Bogdanova A, Martínez-Ruiz A. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia. Redox Biology. 12: 1040-1051. PMID 28511347 DOI: 10.1016/J.Redox.2017.04.025  0.786
2017 Ramos E, Egea J, de Los Ríos C, Marco-Contelles J, Romero A. Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration. Future Medicinal Chemistry. PMID 28498717 DOI: 10.4155/Fmc-2017-0014  0.357
2017 Hue MG, Farré-Alins V, Antolín AP, Parada E, Rubio-Navarro A, Egido J, Egea J, Moreno JA. Targeting Nrf2 in the Protection against Renal Disease. Current Medicinal Chemistry. PMID 28494744 DOI: 10.2174/0929867324666170511120814  0.752
2017 Romero A, Parada E, González-Lafuente L, Farré-Alins V, Ramos E, Cacabelos R, Egea J. Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®). Cns Neuroscience & Therapeutics. PMID 28371323 DOI: 10.1111/Cns.12693  0.711
2017 Monjas L, Arce MP, León R, Egea J, Pérez C, Villarroya M, López MG, Gil C, Conde S, Rodríguez-Franco MI. Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European Journal of Medicinal Chemistry. 130: 60-72. PMID 28242552 DOI: 10.1016/J.Ejmech.2017.02.034  0.711
2017 Budni J, Molz S, Dal-Cim T, Martín-de-Saavedra MD, Egea J, Lopéz MG, Tasca CI, Rodrigues AL. Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS. Molecular Neurobiology. PMID 28185129 DOI: 10.1007/S12035-017-0425-6  0.726
2017 Ramos E, Patiño P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, Los Rios C, Romero A, Egea J. Ischemic brain injury: new insights on the protective role of melatonin. Free Radical Biology & Medicine. PMID 28065781 DOI: 10.1016/J.Freeradbiomed.2017.01.005  0.767
2016 Rieger DK, Navarro E, Buendia I, Parada E, González-Lafuente L, Leon R, Costa AP, Heinrich IA, Nascimento KS, Cavada BS, Lopez MG, Egea J, Leal RB. ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels. Neurochemical Research. PMID 27747481 DOI: 10.1007/S11064-016-2078-7  0.805
2016 Benchekroun M, Romero A, Egea J, León R, Michalska P, Buendia I, Jimeno ML, Jun D, Janockova J, Sepsova V, Soukup O, Bautista-Aguilera OM, Refouvelet B, Ouari O, Marco-Contelles J, et al. The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators. Journal of Medicinal Chemistry. PMID 27736061 DOI: 10.1021/Acs.Jmedchem.6B01178  0.39
2016 Patiño P, Parada E, Farré-Alins V, Molz S, Cacabelos R, Marco-Contelles J, López MG, Tasca CI, Ramos E, Romero A, Egea J. Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices. Neurotoxicology. 57: 61-68. PMID 27620136 DOI: 10.1016/J.Neuro.2016.09.002  0.818
2016 De Pascual R, Colmena I, Ruiz-Pascual L, Baraibar AM, Egea J, Gandía L, García AG. Regulation by L channels of Ca(2+)-evoked secretory responses in ouabain-treated chromaffin cells. Pflugers Archiv : European Journal of Physiology. PMID 27558258 DOI: 10.1007/S00424-016-1866-X  0.714
2015 Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, López MG, Egea J, et al. Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation and X-ray Crystallography. Journal of Medicinal Chemistry. PMID 26632651 DOI: 10.1021/Acs.Jmedchem.5B01119  0.711
2015 Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, León R. Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics. PMID 26617217 DOI: 10.1016/J.Pharmthera.2015.11.003  0.403
2015 Buendia I, Navarro E, Michalska P, Gameiro I, Egea J, Abril S, López A, González-Lafuente L, López MG, León R. New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection. Future Medicinal Chemistry. PMID 26496465 DOI: 10.4155/Fmc.15.99  0.747
2015 Moreno-Ortega AJ, Buendia I, Mouhid L, Egea J, Lucea S, Ruiz-Nuño A, López MG, Cano-Abad MF. CALHM1 and its polymorphism P86L differentially control Ca(2+) homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β. Aging Cell. PMID 26416646 DOI: 10.1111/Acel.12403  0.727
2015 Egea J, Buendia I, Parada E, Navarro E, León R, Lopez MG. Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection. Biochemical Pharmacology. 97: 463-72. PMID 26232730 DOI: 10.1016/J.Bcp.2015.07.032  0.801
2015 Navarro E, Buendia I, Parada E, León R, Jansen-Duerr P, Pircher H, Egea J, Lopez MG. Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction. Biochemical Pharmacology. 97: 473-81. PMID 26212551 DOI: 10.1016/J.Bcp.2015.07.022  0.817
2015 Buendia I, Gómez-Rangel V, González-Lafuente L, Parada E, León R, Gameiro I, Michalska P, Laudon M, Egea J, López MG. Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. Neuropharmacology. 99: 187-195. PMID 26188145 DOI: 10.1016/J.Neuropharm.2015.07.014  0.812
2015 Buendia I, Parada E, Navarro E, León R, Negredo P, Egea J, López MG. Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures. Molecular Neurobiology. PMID 26081146 DOI: 10.1007/S12035-015-9272-5  0.799
2015 Parada E, Buendia I, Navarro E, Avendaño C, Egea J, López MG. Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Molecular Nutrition & Food Research. 59: 1690-700. PMID 26047311 DOI: 10.1002/Mnfr.201500279  0.802
2015 Freitas AE, Egea J, Buendia I, Gómez-Rangel V, Parada E, Navarro E, Casas AI, Wojnicz A, Ortiz JA, Cuadrado A, Ruiz-Nuño A, Rodrigues AL, Lopez MG. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular Neurobiology. PMID 25966970 DOI: 10.1007/S12035-015-9182-6  0.784
2015 Guerra-Álvarez M, Moreno-Ortega AJ, Navarro E, Fernández-Morales JC, Egea J, López MG, Cano-Abad MF. Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum. Journal of Neurochemistry. 133: 309-19. PMID 25650007 DOI: 10.1111/Jnc.13049  0.723
2015 Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, López MG, Wehle S, Gharbi T, Refouvelet B, de Andrés L, Herrera-Arozamena C, et al. Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids. Chemmedchem. 10: 523-39. PMID 25537267 DOI: 10.1002/Cmdc.201402409  0.731
2015 Egea J, Buendia I, Parada E, Navarro E, Rada P, Cuadrado A, López MG, García AG, León R. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. British Journal of Pharmacology. 172: 1807-21. PMID 25425158 DOI: 10.1111/Bph.13025  0.794
2015 Buendia I, Egea J, Parada E, Navarro E, León R, Rodríguez-Franco MI, López MG. The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction. Acs Chemical Neuroscience. 6: 288-96. PMID 25393881 DOI: 10.1021/Cn5002073  0.805
2015 Freitas AE, Egea J, Buendía I, Navarro E, Rada P, Cuadrado A, Rodrigues AL, López MG. Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line. Molecular Neurobiology. 51: 1504-19. PMID 25084759 DOI: 10.1007/S12035-014-8827-1  0.789
2015 Casas AI, Langhauser F, Mencl S, Egea J, Dao VT, Kleikers PW, García López M, Kleinschnitz C, HHW Schmidt H. NOX, NOS and sGC as new therapeutic targets in stroke Free Radical Biology and Medicine. 86: S43. DOI: 10.1016/J.Freeradbiomed.2015.07.146  0.379
2015 López MG, Parada E, Egea J. Importance of microglial α7 nicotinic receptors in neuroprotection: The central cholinergic anti-inflammatory pathway Biochemical Pharmacology. 97: 625. DOI: 10.1016/J.Bcp.2015.08.015  0.777
2015 Buendia I, Parada E, Navarro E, León R, Negredo P, Egea J, López MG. Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures Molecular Neurobiology. DOI: 10.1007/s12035-015-9272-5  0.703
2015 Freitas AE, Egea J, Buendia I, Gómez-Rangel V, Parada E, Navarro E, Casas AI, Wojnicz A, Ortiz JA, Cuadrado A, Ruiz-Nuño A, Rodrigues ALS, Lopez MG. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice Molecular Neurobiology. DOI: 10.1007/s12035-015-9182-6  0.771
2015 Parada E, Buendia I, Navarro E, Avendaño C, Egea J, López MG. Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects Molecular Nutrition and Food Research. DOI: 10.1002/mnfr.201500279  0.738
2014 Cunha MP, Martín-de-Saavedra MD, Romero A, Egea J, Ludka FK, Tasca CI, Farina M, Rodrigues AL, López MG. Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model. Asn Neuro. 6. PMID 25424428 DOI: 10.1177/1759091414554945  0.753
2014 Romero A, Egea J, González-Muñoz GC, Martín de Saavedra MD, del Barrio L, Rodríguez-Franco MI, Conde S, López MG, Villarroya M, de los Ríos C. ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease. Acs Chemical Neuroscience. 5: 770-5. PMID 25008046 DOI: 10.1021/Cn500131T  0.737
2014 Tenti G, Parada E, León R, Egea J, Martínez-Revelles S, Briones AM, Sridharan V, López MG, Ramos MT, Menéndez JC. New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury. Journal of Medicinal Chemistry. 57: 4313-23. PMID 24754640 DOI: 10.1021/Jm500263V  0.766
2014 Romero A, Ramos E, de Los Ríos C, Egea J, Del Pino J, Reiter RJ. A review of metal-catalyzed molecular damage: protection by melatonin. Journal of Pineal Research. 56: 343-70. PMID 24628077 DOI: 10.1111/Jpi.12132  0.332
2014 Egea J, Romero A, Parada E, León R, Dal-Cim T, López MG. Neuroprotective effect of dimebon against ischemic neuronal damage. Neuroscience. 267: 11-21. PMID 24607349 DOI: 10.1016/J.Neuroscience.2014.02.025  0.78
2014 Rojo AI, McBean G, Cindric M, Egea J, López MG, Rada P, Zarkovic N, Cuadrado A. Redox control of microglial function: molecular mechanisms and functional significance. Antioxidants & Redox Signaling. 21: 1766-801. PMID 24597893 DOI: 10.1089/Ars.2013.5745  0.777
2014 Egea J, Parada E, Gómez-Rangel V, Buendia I, Negredo P, Montell E, Ruhí R, Vergés J, Roda JM, García AG, López MG. Small synthetic hyaluronan disaccharides afford neuroprotection in brain ischemia-related models. Neuroscience. 265: 313-22. PMID 24486437 DOI: 10.1016/J.Neuroscience.2014.01.032  0.764
2014 Parada E, Buendia I, León R, Negredo P, Romero A, Cuadrado A, López MG, Egea J. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. Journal of Pineal Research. 56: 204-12. PMID 24350834 DOI: 10.1111/Jpi.12113  0.811
2014 Buendia I, Navarro E, Egea J, Parada E, López MG. P1-420: COMBINATION OF SUBEFFECTIVE CONCENTRATIONS OF MELATONIN AND GALANTAMINE IMPROVES ALZHEIMER'S LIKE PATHOLOGY IN ORGANOTYPIC HIPPOCAMPAL SLICES EXPOSED TO THE ASSOCIATION OF B-AMYLOID AND OKADAIC ACID Alzheimer's & Dementia. 10: P467-P468. DOI: 10.1016/J.Jalz.2014.05.663  0.777
2014 Navarro E, Buendia I, Parada E, Egea J, López MG. P1-419: ALPHA-7 NICOTINIC RECEPTOR STIMULATION OFFERS NEUROPROTECTION IN A MODEL OF ALZHEIMER'S DISEASE BASED ON OXIDATIVE STRESS Alzheimer's & Dementia. 10: P467-P467. DOI: 10.1016/J.Jalz.2014.05.662  0.792
2013 Dal-Cim T, Ludka FK, Martins WC, Reginato C, Parada E, Egea J, López MG, Tasca CI. Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions. Journal of Neurochemistry. 126: 437-50. PMID 23713463 DOI: 10.1111/Jnc.12324  0.782
2013 Cunha MP, Martín-de-Saavedra MD, Romero A, Parada E, Egea J, Del Barrio L, Rodrigues AL, López MG. Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways. Neuroscience. 238: 185-94. PMID 23485810 DOI: 10.1016/J.Neuroscience.2013.02.030  0.799
2013 Jacques AV, Rieger DK, Maestri M, Lopes MW, Peres TV, Gonçalves FM, Pedro DZ, Tasca CI, López MG, Egea J, Nascimento KS, Cavada BS, Leal RB. Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway. Neurochemistry International. 62: 836-42. PMID 23454192 DOI: 10.1016/J.Neuint.2013.02.020  0.353
2013 Romero A, Gomez-Rangel V, Egea J, Samadi A, Marco-Contelles J, Lopez MG. Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices. Cns Neuroscience & Therapeutics. 19: 285-7. PMID 23441748 DOI: 10.1111/Cns.12073  0.693
2013 Parada E, Egea J, Buendia I, Negredo P, Cunha AC, Cardoso S, Soares MP, López MG. The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2. Antioxidants & Redox Signaling. 19: 1135-48. PMID 23311871 DOI: 10.1089/Ars.2012.4671  0.785
2013 Lorrio S, Gómez-Rangel V, Negredo P, Egea J, Leon R, Romero A, Dal-Cim T, Villarroya M, Rodriguez-Franco MI, Conde S, Arce MP, Roda JM, García AG, López MG. Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia. Neuropharmacology. 67: 403-11. PMID 23228428 DOI: 10.1016/J.Neuropharm.2012.12.001  0.444
2012 González-Lafuente L, Egea J, León R, Martínez-Sanz FJ, Monjas L, Perez C, Merino C, García-De Diego AM, Rodríguez-Franco MI, García AG, Villarroya M, López MG, de Los Ríos C. Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry. Acs Chemical Neuroscience. 3: 519-29. PMID 22860221 DOI: 10.1021/Cn300009E  0.414
2012 Dal-Cim T, Molz S, Egea J, Parada E, Romero A, Budni J, Martín de Saavedra MD, del Barrio L, Tasca CI, López MG. Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway. Neurochemistry International. 61: 397-404. PMID 22683349 DOI: 10.1016/J.Neuint.2012.05.021  0.823
2012 Egea J, Malmierca E, Rosa AO, del Barrio L, Negredo P, Nuñez A, López MG. Participation of calbindin-D28K in nociception: results from calbindin-D28K knockout mice. Pflã¼Gers Archiv : European Journal of Physiology. 463: 449-58. PMID 22134771 DOI: 10.1007/S00424-011-1063-X  0.667
2012 Egea J, Martín-de-Saavedra MD, Parada E, Romero A, Del Barrio L, Rosa AO, García AG, López MG. Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation. Neuropharmacology. 62: 1082-90. PMID 22085833 DOI: 10.1016/J.Neuropharm.2011.10.022  0.824
2011 Egea J, de los Rios C. 1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease. Current Topics in Medicinal Chemistry. 11: 2807-23. PMID 22039881 DOI: 10.2174/156802611798184418  0.344
2011 Del Barrio L, Martín-de-Saavedra MD, Romero A, Parada E, Egea J, Avila J, McIntosh JM, Wonnacott S, López MG. Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 193-205. PMID 21715663 DOI: 10.1093/Toxsci/Kfr163  0.812
2011 Molz S, Dal-Cim T, Budni J, Martín-de-Saavedra MD, Egea J, Romero A, del Barrio L, Rodrigues AL, López MG, Tasca CI. Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition. Journal of Neuroscience Research. 89: 1400-8. PMID 21671255 DOI: 10.1002/Jnr.22681  0.719
2011 Budni J, Romero A, Molz S, Martín-de-Saavedra MD, Egea J, Del Barrio L, Tasca CI, Rodrigues AL, López MG. Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid. Neuroscience. 190: 346-53. PMID 21640799 DOI: 10.1016/J.Neuroscience.2011.05.053  0.724
2011 González-Muñoz GC, Arce MP, López B, Pérez C, Romero A, del Barrio L, Martín-de-Saavedra MD, Egea J, León R, Villarroya M, López MG, García AG, Conde S, Rodríguez-Franco MI. N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 46: 2224-35. PMID 21420206 DOI: 10.1016/J.Ejmech.2011.03.003  0.725
2011 Martín-de-Saavedra MD, del Barrio L, Cañas N, Egea J, Lorrio S, Montell E, Vergés J, García AG, López MG. Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS. Neurochemistry International. 58: 676-83. PMID 21335047 DOI: 10.1016/J.Neuint.2011.02.006  0.733
2011 del Barrio L, Egea J, León R, Romero A, Ruiz A, Montero M, Alvarez J, López MG. Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release. British Journal of Pharmacology. 162: 94-110. PMID 20840468 DOI: 10.1111/J.1476-5381.2010.01034.X  0.708
2011 Martins DF, Rosa AO, Gadotti VM, Mazzardo-Martins L, Nascimento FP, Egea J, López MG, Santos AR. The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice. The Journal of Pain : Official Journal of the American Pain Society. 12: 315-22. PMID 20705523 DOI: 10.1016/J.Jpain.2010.06.007  0.318
2010 Parada E, Egea J, Romero A, del Barrio L, García AG, López MG. Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. Free Radical Biology & Medicine. 49: 1815-21. PMID 20875851 DOI: 10.1016/J.Freeradbiomed.2010.09.017  0.813
2010 Nicolau SM, Egea J, López MG, García AG. Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. Biochemical and Biophysical Research Communications. 400: 140-4. PMID 20713022 DOI: 10.1016/J.Bbrc.2010.08.028  0.414
2010 de Los Ríos C, Egea J, Marco-Contelles J, León R, Samadi A, Iriepa I, Moraleda I, Gálvez E, García AG, López MG, Villarroya M, Romero A. Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives. Journal of Medicinal Chemistry. 53: 5129-43. PMID 20575555 DOI: 10.1021/Jm901902W  0.398
2010 Romero A, Egea J, García AG, López MG. Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. Journal of Pineal Research. 49: 141-8. PMID 20536682 DOI: 10.1111/J.1600-079X.2010.00778.X  0.437
2010 Egea J, García AG, Verges J, Montell E, López MG. Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 18: S24-7. PMID 20399898 DOI: 10.1016/J.Joca.2010.01.016  0.421
2009 Egea J, Rosa AO, Lorrio S, del Barrio L, Cuadrado A, López MG. Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test. Pain. 146: 75-83. PMID 19660867 DOI: 10.1016/J.Pain.2009.07.007  0.756
2009 Nicolau SM, de Diego AM, Cortés L, Egea J, González JC, Mosquera M, López MG, Hernández-Guijo JM, García AG. Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine. The Journal of Pharmacology and Experimental Therapeutics. 330: 844-54. PMID 19509314 DOI: 10.1124/Jpet.109.154765  0.375
2009 Valero T, del Barrio L, Egea J, Cañas N, Martínez A, García AG, Villarroya M, López MG. NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells. European Journal of Pharmacology. 607: 47-53. PMID 19233161 DOI: 10.1016/J.Ejphar.2009.02.021  0.716
2009 Burgos-Ramos E, Martos-Moreno GA, López MG, Herranz R, Aguado-Llera D, Egea J, Frechilla D, Cenarruzabeitia E, León R, Arilla-Ferreiro E, Argente J, Barrios V. The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation. Journal of Neurochemistry. 109: 360-70. PMID 19220704 DOI: 10.1111/J.1471-4159.2009.05980.X  0.354
2008 Rojo AI, Rada P, Egea J, Rosa AO, López MG, Cuadrado A. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Molecular and Cellular Neurosciences. 39: 125-32. PMID 18619545 DOI: 10.1016/J.Mcn.2008.06.007  0.576
2008 Rosa AO, Egea J, Martínez A, García AG, López MG. Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPARgamma receptors. Experimental Neurology. 212: 93-9. PMID 18471812 DOI: 10.1016/J.Expneurol.2008.03.008  0.358
2008 Rosa AO, Egea J, Lorrio S, Rojo AI, Cuadrado A, López MG. Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice. Pain. 137: 332-9. PMID 17964723 DOI: 10.1016/J.Pain.2007.09.015  0.549
2007 González JC, Egea J, Del Carmen Godino M, Fernandez-Gomez FJ, Sánchez-Prieto J, Gandía L, García AG, Jordán J, Hernández-Guijo JM. Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons. The European Journal of Neuroscience. 26: 2481-95. PMID 17986028 DOI: 10.1111/J.1460-9568.2007.05873.X  0.347
2007 Egea J, Rosa AO, Cuadrado A, García AG, López MG. Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. Journal of Neurochemistry. 102: 1842-52. PMID 17540012 DOI: 10.1111/J.1471-4159.2007.04665.X  0.621
2007 Egea J, Rosa AO, Sobrado M, Gandía L, López MG, García AG. Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice. Neuroscience. 145: 866-72. PMID 17291692 DOI: 10.1016/J.Neuroscience.2006.12.036  0.353
2006 Tapia L, Eguiagaray JG, Egea J, García AG, Gandía L. Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells. Journal of Molecular Neuroscience : Mn. 30: 81-2. PMID 17192638 DOI: 10.1385/Jmn:30:1:81  0.321
2006 Rosa AO, Egea J, Gandía L, López MG, García AG. Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype. Journal of Molecular Neuroscience : Mn. 30: 61-2. PMID 17192628 DOI: 10.1385/Jmn:30:1:61  0.327
2006 Egea J, Hernández-Guijo JM, Olivares R, López MG, García AG. Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells. Journal of Molecular Neuroscience : Mn. 30: 59-60. PMID 17192627 DOI: 10.1385/Jmn:30:1:59  0.319
2006 González-Rubio JM, García de Diego AM, Egea J, Olivares R, Rojo J, Gandía L, García AG, Hernández-Guijo JM. Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine. European Journal of Pharmacology. 535: 13-24. PMID 16530180 DOI: 10.1016/J.Ejphar.2006.01.057  0.315
2006 Egea J, Rosa AO, Gandia L, López MG, Garcı́a AG. P1-096: Direct proof from transgenic mice for α7 nAChR-mediated neuroprotection in hippocampal slices subjected to anoxia Alzheimer's & Dementia. 2: S123-S123. DOI: 10.1016/J.Jalz.2006.05.471  0.763
2004 Sobrado M, Roda JM, López MG, Egea J, García AG. Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation. Neuroscience Letters. 365: 132-6. PMID 15245794 DOI: 10.1016/J.Neulet.2004.04.067  0.351
2004 Eguiagaray JG, Egea J, Bravo-Cordero JJ, García AG. [Neurotransmitters, calcium signalling and neuronal communication]. Neurocirugã­a (Asturias, Spain). 15: 109-18. PMID 15159788 DOI: 10.1016/S1130-1473(04)70489-3  0.344
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