Kenji Fukasawa - Publications

Affiliations: 
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States 

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Peng L, Yuan Z, Li Y, Ling H, Izumi V, Fang B, Fukasawa K, Koomen J, Chen J, Seto E. Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival. The Journal of Biological Chemistry. 290: 8904-12. PMID 25670865 DOI: 10.1074/Jbc.M114.612796  0.352
2015 Ling H, Hanashiro K, Luong TH, Benavides L, Fukasawa K. Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification. Cell Cycle (Georgetown, Tex.). 14: 544-53. PMID 25590559 DOI: 10.4161/15384101.2014.989121  0.499
2012 Ling H, Peng L, Seto E, Fukasawa K. Suppression of centrosome duplication and amplification by deacetylases. Cell Cycle (Georgetown, Tex.). 11: 3779-91. PMID 23022877 DOI: 10.4161/Cc.21985  0.385
2012 Tarapore P, Hanashiro K, Fukasawa K. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell Cycle (Georgetown, Tex.). 11: 2931-46. PMID 22833046 DOI: 10.4161/Cc.21396  0.334
2012 Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Molecular and Cellular Biology. 32: 2823-36. PMID 22586264 DOI: 10.1128/Mcb.00496-12  0.341
2012 Reboutier D, Troadec MB, Cremet JY, Fukasawa K, Prigent C. Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89. The Journal of Cell Biology. 197: 19-26. PMID 22451695 DOI: 10.1083/jcb.201107134  0.324
2011 Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Molecular and Cellular Biology. 31: 4720-34. PMID 21947282 DOI: 10.1128/Mcb.06147-11  0.327
2011 Fukasawa K. Aberrant activation of cell cycle regulators, centrosome amplification, and mitotic defects. Hormones & Cancer. 2: 104-12. PMID 21761333 DOI: 10.1007/s12672-010-0060-4  0.345
2011 Hanashiro K, Brancaccio M, Fukasawa K. Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification. Oncogene. 30: 2188-97. PMID 21242972 DOI: 10.1038/Onc.2010.607  0.514
2010 Kanai M, Crowe MS, Zheng Y, Vande Woude GF, Fukasawa K. RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication. Oncogene. 29: 6040-50. PMID 20697357 DOI: 10.1038/Onc.2010.328  0.385
2009 Hirai H, Iwasawa Y, Okada M, Arai T, Nishibata T, Kobayashi M, Kimura T, Kaneko N, Ohtani J, Yamanaka K, Itadani H, Takahashi-Suzuki I, Fukasawa K, Oki H, Nambu T, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Molecular Cancer Therapeutics. 8: 2992-3000. PMID 19887545 DOI: 10.1158/1535-7163.MCT-09-0463  0.349
2008 Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M, Fukasawa K, Sugimura H. Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). The Journal of Pathology. 216: 365-74. PMID 18788085 DOI: 10.1002/Path.2422  0.426
2008 Hanashiro K, Kanai M, Geng Y, Sicinski P, Fukasawa K. Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene. 27: 5288-302. PMID 18490919 DOI: 10.1038/Onc.2008.161  0.588
2008 Fukasawa K. P53, cyclin-dependent kinase and abnormal amplification of centrosomes. Biochimica Et Biophysica Acta. 1786: 15-23. PMID 18472015 DOI: 10.1016/j.bbcan.2008.04.002  0.485
2007 Kanai M, Hanashiro K, Kim SH, Hanai S, Boulares AH, Miwa M, Fukasawa K. Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nature Cell Biology. 9: 1175-83. PMID 17891139 DOI: 10.1038/Ncb1638  0.422
2007 Kanai M, Ma Z, Izumi H, Kim SH, Mattison CP, Winey M, Fukasawa K. Physical and functional interaction between mortalin and Mps1 kinase. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 12: 797-810. PMID 17573779 DOI: 10.1111/J.1365-2443.2007.01091.X  0.416
2007 Liu X, Liu Z, Jang SW, Ma Z, Shinmura K, Kang S, Dong S, Chen J, Fukasawa K, Ye K. Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival. Proceedings of the National Academy of Sciences of the United States of America. 104: 9679-84. PMID 17535915 DOI: 10.1073/Pnas.0701806104  0.382
2007 Shinmura K, Bennett RA, Tarapore P, Fukasawa K. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene. 26: 2939-44. PMID 17072342 DOI: 10.1038/Sj.Onc.1210085  0.54
2006 Ma Z, Kanai M, Kawamura K, Kaibuchi K, Ye K, Fukasawa K. Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Molecular and Cellular Biology. 26: 9016-34. PMID 17015463 DOI: 10.1128/Mcb.01383-06  0.444
2006 Ma Z, Izumi H, Kanai M, Kabuyama Y, Ahn NG, Fukasawa K. Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene. 25: 5377-90. PMID 16619038 DOI: 10.1038/Sj.Onc.1209543  0.527
2006 Sugihara E, Kanai M, Saito S, Nitta T, Toyoshima H, Nakayama K, Nakayama KI, Fukasawa K, Schwab M, Saya H, Miwa M. Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Research. 66: 4020-9. PMID 16618721 DOI: 10.1158/0008-5472.Can-05-3250  0.543
2006 Tarapore P, Shinmura K, Suzuki H, Tokuyama Y, Kim SH, Mayeda A, Fukasawa K. Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. Febs Letters. 580: 399-409. PMID 16376875 DOI: 10.1016/J.Febslet.2005.12.022  0.437
2006 Knauf JA, Ouyang B, Knudsen ES, Fukasawa K, Babcock G, Fagin JA. Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. The Journal of Biological Chemistry. 281: 3800-9. PMID 16316983 DOI: 10.1074/Jbc.M511690200  0.408
2005 Shinmura K, Tarapore P, Tokuyama Y, George KR, Fukasawa K. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. Febs Letters. 579: 6621-34. PMID 16297385 DOI: 10.1016/J.Febslet.2005.10.057  0.377
2005 Fukasawa K. Centrosome amplification, chromosome instability and cancer development. Cancer Letters. 230: 6-19. PMID 16253756 DOI: 10.1016/J.Canlet.2004.12.028  0.447
2005 Mayhew CN, Bosco EE, Fox SR, Okaya T, Tarapore P, Schwemberger SJ, Babcock GF, Lentsch AB, Fukasawa K, Knudsen ES. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Research. 65: 4568-77. PMID 15930274 DOI: 10.1158/0008-5472.Can-04-4221  0.33
2005 Oikawa T, Okuda M, Ma Z, Goorha R, Tsujimoto H, Inokuma H, Fukasawa K. Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1. Molecular and Cellular Biology. 25: 4046-61. PMID 15870277 DOI: 10.1128/Mcb.25.10.4046-4061.2005  0.518
2005 Takaki T, Fukasawa K, Suzuki-Takahashi I, Semba K, Kitagawa M, Taya Y, Hirai H. Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro. Journal of Biochemistry. 137: 381-6. PMID 15809340 DOI: 10.1093/jb/mvi050  0.361
2004 Bennett RA, Izumi H, Fukasawa K. Induction of centrosome amplification and chromosome instability in p53-null cells by transient exposure to subtoxic levels of S-phase-targeting anticancer drugs. Oncogene. 23: 6823-9. PMID 15273731 DOI: 10.1038/Sj.Onc.1207561  0.454
2004 Kawamura K, Izumi H, Ma Z, Ikeda R, Moriyama M, Tanaka T, Nojima T, Levin LS, Fujikawa-Yamamoto K, Suzuki K, Fukasawa K. Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Cancer Research. 64: 4800-9. PMID 15256449 DOI: 10.1158/0008-5472.Can-03-3908  0.533
2004 Takaki T, Fukasawa K, Suzuki-Takahashi I, Hirai H. Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro. Biochemical and Biophysical Research Communications. 316: 252-5. PMID 15003538 DOI: 10.1016/j.bbrc.2004.02.044  0.354
2003 Forgues M, Difilippantonio MJ, Linke SP, Ried T, Nagashima K, Feden J, Valerie K, Fukasawa K, Wang XW. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Molecular and Cellular Biology. 23: 5282-92. PMID 12861014 DOI: 10.1128/Mcb.23.15.5282-5292.2003  0.423
2003 Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G. Inactivation of E2F3 results in centrosome amplification. Cancer Cell. 3: 333-46. PMID 12726860 DOI: 10.1016/S1535-6108(03)00083-7  0.477
2003 Kanai M, Tong WM, Sugihara E, Wang ZQ, Fukasawa K, Miwa M. Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function. Molecular and Cellular Biology. 23: 2451-62. PMID 12640128 DOI: 10.1128/Mcb.23.7.2451-2462.2003  0.466
2002 Tarapore P, Okuda M, Fukasawa K. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell Cycle (Georgetown, Tex.). 1: 75-81. PMID 12429912 DOI: 10.4161/Cc.1.1.103  0.527
2002 Tarapore P, Fukasawa K. Loss of p53 and centrosome hyperamplification. Oncogene. 21: 6234-40. PMID 12214254 DOI: 10.1038/Sj.Onc.1205707  0.565
2002 Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES. Active RB elicits late G1/S inhibition. Experimental Cell Research. 276: 201-13. PMID 12027450 DOI: 10.1006/Excr.2002.5510  0.734
2002 Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W. Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. Molecular and Cellular Biology. 22: 3450-9. PMID 11971976 DOI: 10.1128/Mcb.22.10.3450-3459.2002  0.48
2001 Tarapore P, Tokuyama Y, Horn HF, Fukasawa K. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene. 20: 6851-63. PMID 11687964 DOI: 10.1038/Sj.Onc.1204848  0.746
2001 Tarapore P, Horn HF, Tokuyama Y, Fukasawa K. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene. 20: 3173-84. PMID 11423967 DOI: 10.1038/Sj.Onc.1204424  0.77
2001 Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. The Journal of Biological Chemistry. 276: 21529-37. PMID 11278991 DOI: 10.1074/Jbc.M100014200  0.741
2000 Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell. 103: 127-40. PMID 11051553 DOI: 10.1016/S0092-8674(00)00093-3  0.733
2000 Chiba S, Okuda M, Mussman JG, Fukasawa K. Genomic convergence and suppression of centrosome hyperamplification in primary p53-/- cells in prolonged culture. Experimental Cell Research. 258: 310-21. PMID 10896782 DOI: 10.1006/Excr.2000.4916  0.446
2000 Mussman JG, Horn HF, Carroll PE, Okuda M, Tarapore P, Donehower LA, Fukasawa K. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene. 19: 1635-46. PMID 10763820 DOI: 10.1038/Sj.Onc.1203460  0.769
2000 Tarapore P, Fukasawa K. p53 mutation and mitotic infidelity. Cancer Investigation. 18: 148-55. PMID 10705877 DOI: 10.3109/07357900009038246  0.491
1999 Saavedra HI, Fukasawa K, Conn CW, Stambrook PJ. MAPK mediates RAS-induced chromosome instability. The Journal of Biological Chemistry. 274: 38083-90. PMID 10608877 DOI: 10.1074/Jbc.274.53.38083  0.446
1999 Strobeck MW, Okuda M, Yamaguchi H, Schwartz A, Fukasawa K. Morphological transformation induced by activation of the mitogen-activated protein kinase pathway requires suppression of the T-type Ca2+ channel. The Journal of Biological Chemistry. 274: 15694-700. PMID 10336467 DOI: 10.1074/Jbc.274.22.15694  0.341
1999 Carroll PE, Okuda M, Horn HF, Biddinger P, Stambrook PJ, Gleich LL, Li YQ, Tarapore P, Fukasawa K. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene. 18: 1935-44. PMID 10208415 DOI: 10.1038/Sj.Onc.1202515  0.727
1998 Ouyang B, Lan Z, Meadows J, Pan H, Fukasawa K, Li W, Dai W. Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 877-85. PMID 9790499  0.343
1998 Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD, Vande Woude GF. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science (New York, N.Y.). 280: 734-7. PMID 9563949 DOI: 10.1126/Science.280.5364.734  0.371
1997 Fukasawa K, Wiener F, Vande Woude GF, Mai S. Genomic instability and apoptosis are frequent in p53 deficient young mice. Oncogene. 15: 1295-302. PMID 9315097 DOI: 10.1038/Sj.Onc.1201482  0.46
1997 Duesbery NS, Choi T, Brown KD, Wood KW, Resau J, Fukasawa K, Cleveland DW, Vande Woude GF. CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II. Proceedings of the National Academy of Sciences of the United States of America. 94: 9165-70. PMID 9256453 DOI: 10.1073/Pnas.94.17.9165  0.413
1997 Fukasawa K, Vande Woude GF. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Molecular and Cellular Biology. 17: 506-18. PMID 8972231 DOI: 10.1128/Mcb.17.1.506  0.51
1996 Choi T, Rulong S, Resau J, Fukasawa K, Matten W, Kuriyama R, Mansour S, Ahn N, Vande Woude GF. Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I. Proceedings of the National Academy of Sciences of the United States of America. 93: 4730-5. PMID 8643471 DOI: 10.1073/Pnas.93.10.4730  0.303
1996 Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science (New York, N.Y.). 271: 1744-7. PMID 8596939 DOI: 10.1126/Science.271.5256.1744  0.505
1995 Resing KA, Mansour SJ, Hermann AS, Johnson RS, Candia JM, Fukasawa K, Vande Woude GF, Ahn NG. Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS. Biochemistry. 34: 2610-20. PMID 7873542 DOI: 10.1021/Bi00008A027  0.353
1995 Fukasawa K, Vande Woude GF. Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle. Proceedings of the National Academy of Sciences of the United States of America. 92: 3430-4. PMID 7724579 DOI: 10.1073/Pnas.92.8.3430  0.348
1994 Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science (New York, N.Y.). 265: 966-70. PMID 8052857 DOI: 10.1126/Science.8052857  0.405
Show low-probability matches.