Timothy Arthur James Haystead - Related publications

1991-1999 Pharmacology University of Virginia, Charlottesville, VA 
 2000- Pharmacology & Cancer Biology Duke University, Durham, NC 
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Woodall NB, Weinberg Z, Park J, Busch F, Johnson RS, Feldbauer MJ, Murphy M, Ahlrichs M, Yousif I, MacCoss MJ, Wysocki VH, El-Samad H, Baker D. De novo design of tyrosine and serine kinase-driven protein switches. Nature Structural & Molecular Biology. 28: 762-770. PMID 34518698 DOI: 10.1038/s41594-021-00649-8   
2021 Zhang A, Pompeo F, Galinier A. Overview of protein phosphorylation in bacteria with a main focus on unusual protein kinases in Bacillus subtilis. Research in Microbiology. 103871. PMID 34500011 DOI: 10.1016/j.resmic.2021.103871   
2021 Sanchez-Garrido J, Shenoy AR. Regulation and repurposing of nutrient sensing and autophagy in innate immunity. Autophagy. 17: 1571-1591. PMID 32627660 DOI: 10.1080/15548627.2020.1783119   
2021 Chen SJ, Bi YH, Zhang LH. Systematic analysis of the potential off-target activities of osimertinib by computational target fishing. Anti-Cancer Drugs. PMID 34459459 DOI: 10.1097/CAD.0000000000001229   
2021 Dong Y, Han H, Li Y, Guo L. [Roles of Histidine Kinases and Histidine Phosphatases in Cancer]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer. PMID 34455734 DOI: 10.3779/j.issn.1009-3419.2021.102.28   
2021 Preynat-Seauve O, Nguyen EB, Westermaier Y, Héritier M, Tardy S, Cambet Y, Feyeux M, Caillon A, Scapozza L, Krause KH. Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation. Frontiers in Pharmacology. 12: 664608. PMID 34421588 DOI: 10.3389/fphar.2021.664608   
2021 Kong L, Zhang Q, Mao J, Cheng L, Shi X, Yu L, Hu J, Yang M, Li L, Liu B, Qian X. A dual-targeted molecular therapy of PP242 and cetuximab plays an anti-tumor effect through EGFR downstream signaling pathways in colorectal cancer. Journal of Gastrointestinal Oncology. 12: 1625-1642. PMID 34532116 DOI: 10.21037/jgo-21-467   
2021 Ramadan M, A M M Elshaier Y, Aly AA, Abdel-Aziz M, Fathy HM, Brown AB, Pridgen JR, Dalby KN, Kaoud TS. Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. Bioorganic Chemistry. 116: 105344. PMID 34598088 DOI: 10.1016/j.bioorg.2021.105344   
2021 Carrasco-Navarro U, Aguirre J. HO Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in . Journal of Fungi (Basel, Switzerland). 7. PMID 34436163 DOI: 10.3390/jof7080624   
2021 Elmas A, Tharakan S, Jaladanki S, Galsky MD, Liu T, Huang KL. Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets. Communications Biology. 4: 1112. PMID 34552204 DOI: 10.1038/s42003-021-02636-7   
2021 Chaisit S, Jianmongkol S. Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells. Biological & Pharmaceutical Bulletin. 44: 1239-1246. PMID 34471052 DOI: 10.1248/bpb.b21-00015   
2021 Hu L, Yang Y, Zheng S, Xu J, Ran T, Chen H. Kinase Inhibitor Scaffold Hopping with Deep Learning Approaches. Journal of Chemical Information and Modeling. PMID 34586824 DOI: 10.1021/acs.jcim.1c00608   
2021 Karia P, Yoshioka K, Moeder W. Multiple phosphorylation events of the mitochondrial membrane protein TTM1 regulate cell death during senescence. The Plant Journal : For Cell and Molecular Biology. PMID 34409658 DOI: 10.1111/tpj.15470   
2021 Yeung W, Kwon A, Taujale R, Bunn C, Venkat A, Kannan N. Evolution of functional diversity in the holozoan tyrosine kinome. Molecular Biology and Evolution. PMID 34515793 DOI: 10.1093/molbev/msab272   
2021 Zhang S, Chen H, Li C, Chen B, Gong H, Zhao Y, Qi R. Water-Soluble Tomato Extract Fruitflow Alters the Phosphoproteomic Profile of Collagen-Stimulated Platelets. Frontiers in Pharmacology. 12: 746107. PMID 34646142 DOI: 10.3389/fphar.2021.746107   
2021 Ma J, Ren Y, Zhang JN, Lin L, Zhang YL. [Analysis on targets of regulating Qi and activating blood based on activity spectrum of targets]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 46: 3970-3979. PMID 34472274 DOI: 10.19540/j.cnki.cjcmm.20210303.401   
2021 Limaye AJ, Bendzunas GN, Kennedy EJ. Targeted disruption of PKC from AKAP signaling complexes. Rsc Chemical Biology. 2: 1227-1231. PMID 34458835 DOI: 10.1039/d1cb00106j   
2021 Minakhina S, De Oliveira V, Kim SY, Zheng H, Wondisford FE. Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic-pituitary-thyroid axis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34544870 DOI: 10.1073/pnas.2107943118   
2021 Wang W, Mevellec L, Liu A, Struble G, Miller R, Allen SJ, Federowicz K, Wroblowski B, Vialard J, Ahn K, Krosky D. Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay. Biochemistry. PMID 34608799 DOI: 10.1021/acs.biochem.1c00486   
2021 Mathis CL, Barrios AM. Histidine phosphorylation in metalloprotein binding sites. Journal of Inorganic Biochemistry. 225: 111606. PMID 34555600 DOI: 10.1016/j.jinorgbio.2021.111606   
2021 Karamafrooz A, Brennan J, Thomas DD, Parker LL. Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A () and Its Oncogenic Mutant 1. Journal of Proteome Research. PMID 34436901 DOI: 10.1021/acs.jproteome.1c00500   
2021 Lin ZY, Yun QZ, Wu L, Zhang TW, Yao TZ. Pharmacological basis and new insights of deguelin concerning its anticancer effects. Pharmacological Research. 105935. PMID 34644595 DOI: 10.1016/j.phrs.2021.105935   
2021 Kondo Y, Paul JW, Subramaniam S, Kuriyan J. New insights into Raf regulation from structural analyses. Current Opinion in Structural Biology. 71: 223-231. PMID 34454301 DOI: 10.1016/j.sbi.2021.07.005   
2021 Huang LC, Taujale R, Gravel N, Venkat A, Yeung W, Byrne DP, Eyers PA, Kannan N. KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases. Bmc Bioinformatics. 22: 446. PMID 34537014 DOI: 10.1186/s12859-021-04358-3   
2021 Chan TY, Egbert CM, Maxson JE, Siddiqui A, Larsen LJ, Kohler K, Balasooriya ER, Pennington KL, Tsang TM, Frey M, Soderblom EJ, Geng H, Müschen M, Forostyan TV, Free S, et al. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. Nature Communications. 12: 5337. PMID 34504101 DOI: 10.1038/s41467-021-25622-3   
2021 Heden TD, Chow LS, Hughey CC, Mashek DG. Regulation and role of glycophagy in skeletal muscle energy metabolism. Autophagy. 1-12. PMID 34506219 DOI: 10.1080/15548627.2021.1969633   
2021 Chiurillo MA, Jensen BC, Docampo R. Drug Target Validation of the Protein Kinase Essential for Proliferation, Host Cell Invasion, and Intracellular Replication of the Human Pathogen Trypanosoma cruzi. Microbiology Spectrum. e0073821. PMID 34585973 DOI: 10.1128/Spectrum.00738-21   
2021 Li Z, Wang X, Hong TP, Wang HJ, Gao ZY, Wan M. Advanced glycosylation end products inhibit the proliferation of bone-marrow stromal cells through activating MAPK pathway. European Journal of Medical Research. 26: 94. PMID 34407888 DOI: 10.1186/s40001-021-00559-x   
2021 Chu YH, Sadow PM. Kinase fusion-related thyroid carcinomas: distinct pathologic entities with evolving diagnostic implications. Diagnostic Histopathology (Oxford, England). 27: 252-262. PMID 34484420 DOI: 10.1016/j.mpdhp.2021.03.003   
2021 Lee JI, Seo JH, Ko ES, Cho SM, Kang JR, Jeong JH, Jeong YJ, Kim CY, Cha JD, Kim WS, Ryu YB. Inhibition of melanogenesis by callus pellet extract in melanoma cells and patients with skin pigmentation. International Journal of Medical Sciences. 18: 3299-3308. PMID 34400899 DOI: 10.7150/ijms.62530   
2021 Serafim RAM, Elkins JM, Zuercher WJ, Laufer SA, Gehringer M. Chemical Probes for Understudied Kinases: Challenges and Opportunities. Journal of Medicinal Chemistry. PMID 34477374 DOI: 10.1021/acs.jmedchem.1c00980   
2021 Ali S, Khan MR, Iqbal J, Batool R, Naz I, Yaseen T, Abbasi BA, Nasir JA, El-Serehy HA. Chemical composition and pharmacological bio-efficacy of (Decne) Rehder for anticancer activity. Saudi Journal of Biological Sciences. 28: 4969-4986. PMID 34466072 DOI: 10.1016/j.sjbs.2021.07.072   
2021 Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T. McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife. 10. PMID 34328418 DOI: 10.7554/eLife.63505   
2021 Drysch M, Schmidt SV, Becerikli M, Reinkemeier F, Dittfeld S, Wagner JM, Dadras M, Sogorski A, von Glinski M, Lehnhardt M, Behr B, Wallner C. Myostatin Deficiency Protects C2C12 Cells from Oxidative Stress by Inhibiting Intrinsic Activation of Apoptosis. Cells. 10. PMID 34359850 DOI: 10.3390/cells10071680   
2021 Lin HH, Hsieh MC, Wang CP, Yu PR, Lee MS, Chen JH. Anti-Atherosclerotic Effect of Gossypetin on Abnormal Vascular Smooth Muscle Cell Proliferation and Migration. Antioxidants (Basel, Switzerland). 10. PMID 34572989 DOI: 10.3390/antiox10091357   
2021 Asati V, Anant A, Patel P, Kaur K, Gupta GD. Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches. European Journal of Medicinal Chemistry. 225: 113781. PMID 34438126 DOI: 10.1016/j.ejmech.2021.113781   
2021 Wu HJ, Zhang K, Ma JJ, Wang L, Zhuang Y. Mechanism of curcumin against myocardial ischaemia-reperfusion injury based on the P13K/Akt/mTOR signalling pathway. European Review For Medical and Pharmacological Sciences. 25: 5490-5499. PMID 34533799 DOI: 10.26355/eurrev_202109_26658   
2021 Moradi A, Dai S, Wong EOY, Zhu G, Yu F, Lam HM, Wang Z, Burlingame A, Lin C, Afsharifar A, Yu W, Wang T, Li N. Isotopically Dimethyl Labeling-Based Quantitative Proteomic Analysis of Phosphoproteomes of Soybean Cultivars. Biomolecules. 11. PMID 34439883 DOI: 10.3390/biom11081218   
2021 Shen Z, Yan YH, Yang S, Zhu S, Yuan Y, Qiu Z, Jia H, Wang R, Li GB, Li H. ProfKin: A comprehensive web server for structure-based kinase profiling. European Journal of Medicinal Chemistry. 225: 113772. PMID 34411891 DOI: 10.1016/j.ejmech.2021.113772   
2021 Hollenstein DM, Gérecová G, Romanov N, Ferrari J, Veis J, Janschitz M, Beyer R, Schüller C, Ogris E, Hartl M, Ammerer G, Reiter W. A phosphatase-centric mechanism drives stress signaling response. Embo Reports. e52476. PMID 34558777 DOI: 10.15252/embr.202152476   
2021 Ortega MA, Fraile-Martínez O, García-Montero C, Ruiz-Grande F, Barrena S, Montoya H, Pekarek L, Zoullas S, Alvarez-Mon MA, Sainz F, Asúnsolo A, Acero J, Álvarez-Mon M, Buján J, García-Honduvilla N, et al. Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall. The Journal of International Medical Research. 49: 3000605211041275. PMID 34590920 DOI: 10.1177/03000605211041275   
2021 Thengchaisri N, Hein TW, Ren Y, Kuo L. Activation of Coronary Arteriolar PKCβ2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation. International Journal of Molecular Sciences. 22. PMID 34575925 DOI: 10.3390/ijms22189763   
2021 Osinski A, Black MH, Pawłowski K, Chen Z, Li Y, Tagliabracci VS. Structural and mechanistic basis for protein glutamylation by the kinase fold. Molecular Cell. PMID 34407442 DOI: 10.1016/j.molcel.2021.08.007   
2021 Hu J, Wang Q, Liu Y. Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 50: 396-402. PMID 34402263 DOI: 10.3724/zdxbyxb-2021-0146   
2021 Dong X, Sun J, Miao W, Chang CA, Wang Y. Proteome-Wide Characterizations of -Methyl-Adenosine Triphosphate- and -Furfuryl-Adenosine Triphosphate-Binding Capabilities of Kinases. Analytical Chemistry. PMID 34549933 DOI: 10.1021/acs.analchem.1c02565   
2021 Elsherbeny MH, Elkamhawy A, Nada H, Abdellattif MH, Lee K, Roh EJ. Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity. Biomedicines. 9. PMID 34572319 DOI: 10.3390/biomedicines9091131   
2021 Lan CN, Cai WJ, Shi J, Yi ZJ. MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy. Molecular Medicine Reports. 24. PMID 34590154 DOI: 10.3892/mmr.2021.12469   
2021 Yun Y, Hong VS, Jeong S, Choo H, Kim S, Lee J. 2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors. Chemical & Pharmaceutical Bulletin. 69: 854-861. PMID 34470949 DOI: 10.1248/cpb.c21-00264   
2021 Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, et al. Structure of an AMPK complex in an inactive, ATP-bound state. Science (New York, N.Y.). 373: 413-419. PMID 34437114 DOI: 10.1126/science.abe7565   
2021 Jee W, Lee SH, Ko HM, Jung JH, Chung WS, Jang HJ. Anti-Obesity Effect of Polygalin C Isolated from Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes. International Journal of Molecular Sciences. 22. PMID 34638751 DOI: 10.3390/ijms221910405