Year |
Citation |
Score |
2012 |
Jiang P, Zhang Y, Atkinson MR, Ninfa AJ. The robustness of the Escherichia coli signal-transducing UTase/UR-PII covalent modification cycle to variation in the PII concentration requires very strong inhibition of the UTase activity of UTase/UR by glutamine. Biochemistry. 51: 9032-44. PMID 23088522 DOI: 10.1021/bi3005736 |
0.384 |
|
2012 |
Perry N, Ninfa AJ. Synthetic networks: oscillators and toggle switches for Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 813: 287-300. PMID 22083749 DOI: 10.1007/978-1-61779-412-4_17 |
0.543 |
|
2012 |
Jiang P, Ventura AC, Sontag ED, Merajver SD, Ninfa AJ, Del Vecchio D. Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" Science Signaling. 5. DOI: 10.1126/Scisignal.2002716 |
0.335 |
|
2011 |
Jiang P, Ninfa AJ. A source of ultrasensitivity in the glutamine response of the bicyclic cascade system controlling glutamine synthetase adenylylation state and activity in Escherichia coli. Biochemistry. 50: 10929-40. PMID 22085244 DOI: 10.1021/bi201410x |
0.351 |
|
2010 |
Ventura AC, Jiang P, Van Wassenhove L, Del Vecchio D, Merajver SD, Ninfa AJ. Signaling properties of a covalent modification cycle are altered by a downstream target. Proceedings of the National Academy of Sciences of the United States of America. 107: 10032-7. PMID 20479260 DOI: 10.1073/Pnas.0913815107 |
0.372 |
|
2010 |
Ninfa AJ. Use of two-component signal transduction systems in the construction of synthetic genetic networks. Current Opinion in Microbiology. 13: 240-5. PMID 20149718 DOI: 10.1016/J.Mib.2010.01.003 |
0.308 |
|
2010 |
Chang DE, Leung S, Atkinson MR, Reifler A, Forger D, Ninfa AJ. Building biological memory by linking positive feedback loops. Proceedings of the National Academy of Sciences of the United States of America. 107: 175-80. PMID 20018658 DOI: 10.1073/Pnas.0908314107 |
0.321 |
|
2009 |
Jiang P, Ninfa AJ. Sensation and signaling of alpha-ketoglutarate and adenylylate energy charge by the Escherichia coli PII signal transduction protein require cooperation of the three ligand-binding sites within the PII trimer. Biochemistry. 48: 11522-31. PMID 19877670 DOI: 10.1021/Bi9011594 |
0.379 |
|
2009 |
Jiang P, Ninfa AJ. Alpha-ketoglutarate controls the ability of the Escherichia coli PII signal transduction protein to regulate the activities of NRII (NrB but does not control the binding of PII to NRII. Biochemistry. 48: 11514-21. PMID 19877669 DOI: 10.1021/Bi901158H |
0.398 |
|
2009 |
Jiang P, Ninfa AJ. Reconstitution of Escherichia coli glutamine synthetase adenylyltransferase from N-terminal and C-terminal fragments of the enzyme. Biochemistry. 48: 415-23. PMID 19105634 DOI: 10.1021/Bi801775B |
0.489 |
|
2008 |
Del Vecchio D, Ninfa AJ, Sontag ED. Modular cell biology: retroactivity and insulation. Molecular Systems Biology. 4: 161. PMID 18277378 DOI: 10.1038/Msb4100204 |
0.339 |
|
2007 |
Jiang P, Ninfa AJ. Escherichia coli PII signal transduction protein controlling nitrogen assimilation acts as a sensor of adenylate energy charge in vitro. Biochemistry. 46: 12979-96. PMID 17939683 DOI: 10.1021/Bi701062T |
0.409 |
|
2007 |
Ninfa AJ, Selinsky S, Perry N, Atkins S, Xiu Song Q, Mayo A, Arps D, Woolf P, Atkinson MR. Using two-component systems and other bacterial regulatory factors for the fabrication of synthetic genetic devices. Methods in Enzymology. 422: 488-512. PMID 17628156 DOI: 10.1016/S0076-6879(06)22025-1 |
0.56 |
|
2007 |
Ninfa AJ. Regulation of carbon and nitrogen metabolism: adding regulation of ion channels and another second messenger to the mix. Proceedings of the National Academy of Sciences of the United States of America. 104: 4243-4. PMID 17360507 DOI: 10.1073/Pnas.0700325104 |
0.377 |
|
2007 |
Jiang P, Mayo AE, Ninfa AJ. Escherichia coli glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49): kinetic characterization of regulation by PII, PII-UMP, glutamine, and alpha-ketoglutarate. Biochemistry. 46: 4133-46. PMID 17355125 DOI: 10.1021/Bi0620510 |
0.411 |
|
2007 |
Jiang P, Pioszak AA, Ninfa AJ. Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli. Biochemistry. 46: 4117-32. PMID 17355124 DOI: 10.1021/Bi0620508 |
0.729 |
|
2005 |
Ninfa AJ, Jiang P. PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism. Current Opinion in Microbiology. 8: 168-73. PMID 15802248 DOI: 10.1016/J.Mib.2005.02.011 |
0.43 |
|
2004 |
Pioszak AA, Ninfa AJ. Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli. Journal of Bacteriology. 186: 5730-40. PMID 15317778 DOI: 10.1128/Jb.186.17.5730-5740.2004 |
0.736 |
|
2004 |
Song Y, Peisach D, Pioszak AA, Xu Z, Ninfa AJ. Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (NRII; NtrB), regulator of nitrogen assimilation in Escherichia coli. Biochemistry. 43: 6670-8. PMID 15157101 DOI: 10.1021/Bi049474R |
0.751 |
|
2004 |
Ninfa AJ, Mayo AE. Hysteresis vs. graded responses: the connections make all the difference. Science's Stke : Signal Transduction Knowledge Environment. 2004: pe20. PMID 15138328 DOI: 10.1126/Stke.2322004Pe20 |
0.347 |
|
2003 |
Bondarenko V, Liu YV, Ninfa AJ, Studitsky VM. Assay of prokaryotic enhancer activity over a distance in vitro. Methods in Enzymology. 370: 324-37. PMID 14712657 DOI: 10.1016/S0076-6879(03)70029-9 |
0.38 |
|
2003 |
Pioszak AA, Ninfa AJ. Mechanism of the PII-activated phosphatase activity of Escherichia coli NRII (NtrB): how the different domains of NRII collaborate to act as a phosphatase. Biochemistry. 42: 8885-99. PMID 12873150 DOI: 10.1021/Bi030065P |
0.728 |
|
2003 |
Atkinson MR, Savageau MA, Myers JT, Ninfa AJ. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell. 113: 597-607. PMID 12787501 DOI: 10.1016/S0092-8674(03)00346-5 |
0.416 |
|
2003 |
Blauwkamp TA, Ninfa AJ. Antagonism of PII signalling by the AmtB protein of Escherichia coli. Molecular Microbiology. 48: 1017-28. PMID 12753193 DOI: 10.1046/J.1365-2958.2003.03479.X |
0.725 |
|
2003 |
Pioszak AA, Ninfa AJ. Genetic and biochemical analysis of phosphatase activity of Escherichia coli NRII (NtrB) and its regulation by the PII signal transduction protein. Journal of Bacteriology. 185: 1299-315. PMID 12562801 DOI: 10.1128/Jb.185.4.1299-1315.2003 |
0.733 |
|
2002 |
Atkinson MR, Pattaramanon N, Ninfa AJ. Governor of the glnAp2 promoter of Escherichia coli. Molecular Microbiology. 46: 1247-57. PMID 12453212 DOI: 10.1046/J.1365-2958.2002.03211.X |
0.408 |
|
2002 |
Blauwkamp TA, Ninfa AJ. Physiological role of the GlnK signal transduction protein of Escherichia coli: survival of nitrogen starvation. Molecular Microbiology. 46: 203-14. PMID 12366843 DOI: 10.1046/J.1365-2958.2002.03153.X |
0.721 |
|
2002 |
Atkinson MR, Blauwkamp TA, Ninfa AJ. Context-dependent functions of the PII and GlnK signal transduction proteins in Escherichia coli. Journal of Bacteriology. 184: 5364-75. PMID 12218023 DOI: 10.1128/Jb.184.19.5364-5375.2002 |
0.732 |
|
2002 |
Atkinson MR, Blauwkamp TA, Bondarenko V, Studitsky V, Ninfa AJ. Activation of the glnA, glnK, and nac promoters as Escherichia coli undergoes the transition from nitrogen excess growth to nitrogen starvation. Journal of Bacteriology. 184: 5358-63. PMID 12218022 DOI: 10.1128/Jb.184.19.5358-5363.2002 |
0.718 |
|
2002 |
Blauwkamp TA, Ninfa AJ. Nac-mediated repression of the serA promoter of Escherichia coli. Molecular Microbiology. 45: 351-63. PMID 12123449 DOI: 10.1046/J.1365-2958.2002.02994.X |
0.725 |
|
2002 |
Bondarenko V, Liu Y, Ninfa A, Studitsky VM. Action of prokaryotic enhancer over a distance does not require continued presence of promoter-bound sigma54 subunit. Nucleic Acids Research. 30: 636-42. PMID 11809874 DOI: 10.1093/Nar/30.3.636 |
0.393 |
|
2002 |
Jiang P, Pioszak A, Atkinson MR, Peliska JA, Ninfa AJ. New Insights into the Mechanism of the Kinase and Phosphatase Activities of Escherichia coli NRII (NtrB) and Their Regulation by the PII Protein Histidine Kinases in Signal Transduction. 143-164. DOI: 10.1016/B978-012372484-7/50008-4 |
0.705 |
|
2001 |
Liu Y, Bondarenko V, Ninfa A, Studitsky VM. DNA supercoiling allows enhancer action over a large distance Proceedings of the National Academy of Sciences of the United States of America. 98: 14883-14888. PMID 11742093 DOI: 10.1073/Pnas.261477898 |
0.305 |
|
2001 |
Ninfa AJ, Jiang P, Atkinson MR, Peliska JA. Integration of antagonistic signals in the regulation of nitrogen assimilation in Escherichia coli Current Topics in Cellular Regulation. 36. PMID 10842746 DOI: 10.1016/S0070-2137(01)80002-9 |
0.408 |
|
2000 |
Pioszak AA, Jiang P, Ninfa AJ. The Escherichia coli PII signal transduction protein regulates the activities of the two-component system transmitter protein NRII by direct interaction with the kinase domain of the transmitter module. Biochemistry. 39: 13450-61. PMID 11063581 DOI: 10.1021/Bi000795M |
0.737 |
|
2000 |
Jiang P, Atkinson MR, Srisawat C, Sun Q, Ninfa AJ. Functional dissection of the dimerization and enzymatic activities of Escherichia coli nitrogen regulator II and their regulation by the PII protein Biochemistry. 39: 13433-13449. PMID 11063580 DOI: 10.1021/Bi000794U |
0.493 |
|
2000 |
Jiang P, Peliska JA, Ninfa AJ. Asymmetry in the autophosphorylation of the two-component regulatory system transmitter protein nitrogen regulator II of Escherichia coli Biochemistry. 39: 5057-5065. PMID 10819971 DOI: 10.1021/Bi992921W |
0.447 |
|
2000 |
Ninfa AJ, Atkinson MR. PII signal transduction proteins. Trends in Microbiology. 8: 172-9. PMID 10754576 DOI: 10.1016/S0966-842X(00)01709-1 |
0.396 |
|
1999 |
Atkinson MR, Ninfa AJ. Characterization of the GlnK protein of Escherichia coli Molecular Microbiology. 32: 301-313. PMID 10231487 DOI: 10.1046/J.1365-2958.1999.01349.X |
0.53 |
|
1999 |
Jiang P, Ninfa AJ. Regulation of autophosphorylation of Escherichia coli nitrogen regulator II by the PII signal transduction protein Journal of Bacteriology. 181: 1906-1911. PMID 10074086 DOI: 10.1128/Jb.181.6.1906-1911.1999 |
0.489 |
|
1998 |
He L, Soupene E, Ninfa A, Kustu S. Physiological role for the GlnK protein of enteric bacteria: relief of NifL inhibition under nitrogen-limiting conditions. Journal of Bacteriology. 180: 6661-7. PMID 9852012 DOI: 10.1128/Jb.180.24.6661-6667.1998 |
0.418 |
|
1998 |
Jiang P, Peliska JA, Ninfa AJ. The regulation of escherichia coli glutamine synthetase revisited: Role of 2-ketoglutarate in the regulation of glutamine synthetase adenylylation state Biochemistry. 37: 12802-12810. PMID 9737857 DOI: 10.1021/Bi980666U |
0.443 |
|
1998 |
Jiang P, Peliska JA, Ninfa AJ. Reconstitution of the signal-transduction bicyclic cascade responsible for the regulation of Ntr gene transcription in Escherichia coli Biochemistry. 37: 12795-12801. PMID 9737856 DOI: 10.1021/Bi9802420 |
0.492 |
|
1998 |
Jiang P, Peliska JA, Ninfa AJ. Enzymological characterization of the signal-transducing uridylyltransferase/uridylyl-removing enzyme (EC 2.7.7.59) of Escherichia coli and its interaction with the PII protein Biochemistry. 37: 12782-12794. PMID 9737855 DOI: 10.1021/Bi980667M |
0.458 |
|
1998 |
Atkinson MR, Ninfa AJ. Role of the GlnK signal transduction protein in the regulation of nitrogen assimilation in Escherichia coli Molecular Microbiology. 29: 431-447. PMID 9720863 DOI: 10.1046/J.1365-2958.1998.00932.X |
0.524 |
|
1998 |
Dworkin J, Ninfa AJ, Model P. A protein-induced DNA bend increases the specificity of a prokaryotic enhancer-binding protein Genes and Development. 12: 894-900. PMID 9512522 DOI: 10.1101/Gad.12.6.894 |
0.432 |
|
1997 |
Wu J, Ohta N, Benson AK, Ninfa AJ, Newton A. Purification, characterization, and reconstitution of DNA-dependent RNA polymerases from Caulobacter crescentus Journal of Biological Chemistry. 272: 21558-21564. PMID 9261176 DOI: 10.1074/Jbc.272.34.21558 |
0.385 |
|
1997 |
Jiang P, Zucker P, Ninfa AJ. Probing interactions of the homotrimeric PII signal transduction protein with its receptors by use of PII heterotrimers formed in vitro from wild-type and mutant subunits. Journal of Bacteriology. 179: 4354-60. PMID 9209054 DOI: 10.1128/Jb.179.13.4354-4360.1997 |
0.397 |
|
1997 |
Jiang P, Zucker P, Atkinson MR, Kamberov ES, Tirasophon W, Chandran P, Schefke BR, Ninfa AJ. Structure/function analysis of the PII signal transduction protein of Escherichia coli: genetic separation of interactions with protein receptors. Journal of Bacteriology. 179: 4342-53. PMID 9209053 DOI: 10.1128/Jb.179.13.4342-4353.1997 |
0.42 |
|
1997 |
Ohta N, Ninfa AJ, Allaire A, Kulick L, Newton A. Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus Journal of Bacteriology. 179: 2169-2180. PMID 9079901 DOI: 10.1128/Jb.179.7.2169-2180.1997 |
0.361 |
|
1996 |
Surette MG, Levit M, Liu Y, Lukat G, Ninfa EG, Ninfa A, Stock JB. Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis. The Journal of Biological Chemistry. 271: 939-45. PMID 8557708 DOI: 10.1074/Jbc.271.2.939 |
0.412 |
|
1995 |
Kamberov ES, Atkinson MR, Ninfa AJ. The Escherichia coli PII signal transduction protein is activated upon binding 2-ketoglutarate and ATP Journal of Biological Chemistry. 270: 17797-17807. PMID 7629080 DOI: 10.1074/Jbc.270.30.17797 |
0.501 |
|
1995 |
Feng J, Goss TJ, Bender RA, Ninfa AJ. Activation of transcription initiation from the nac promoter of Klebsiella aerogenes Journal of Bacteriology. 177: 5523-5534. PMID 7559338 DOI: 10.1128/Jb.177.19.5523-5534.1995 |
0.302 |
|
1994 |
Benson AK, Ramakrishnan G, Ohta N, Feng J, Ninfa AJ, Newton A. The Caulobacter crescentus FlbD protein acts at ftr sequence elements both to activate and to repress transcription of cell cycle-regulated flagellar genes Proceedings of the National Academy of Sciences of the United States of America. 91: 4989-4993. PMID 8197169 DOI: 10.1073/Pnas.91.11.4989 |
0.425 |
|
1994 |
Kamberov ES, Atkinson MR, Chandran P, Ninfa AJ. Effect of mutations in Escherichia coli glnL (ntrB), encoding nitrogen regulator II (NRII or NtrB), on the phosphatase activity involved in bacterial nitrogen regulation Journal of Biological Chemistry. 269: 28294-28299. PMID 7961767 |
0.463 |
|
1994 |
Atkinson MR, Kamberov ES, Weiss RL, Ninfa AJ. Reversible uridylylation of the Escherichia coli PII signal transduction protein regulates its ability to stimulate the dephosphorylation of the transcription factor nitrogen regulator I (NRI or NtrC). The Journal of Biological Chemistry. 269: 28288-93. PMID 7961766 |
0.42 |
|
1994 |
Kamberov ES, Atkinson MR, Feng J, Chandran P, Ninfa AJ. Sensory components controlling bacterial nitrogen assimilation Cellular and Molecular Biology Research. 40: 175-191. PMID 7874194 |
0.432 |
|
1993 |
McCleary WR, Stock JB, Ninfa AJ. Is acetyl phosphate a global signal in Escherichia coli? Journal of Bacteriology. 175: 2793-8. PMID 8491699 DOI: 10.1128/Jb.175.10.2793-2798.1993 |
0.339 |
|
1993 |
Roychoudhury S, Zielinski NA, Ninfa AJ, Allen NE, Jungheim LN, Nicas TI, Chakrabarty AM. Inhibitors of two-component signal transduction systems: Inhibition of alginate gene activation in Pseudomonas aeruginosa Proceedings of the National Academy of Sciences of the United States of America. 90: 965-969. PMID 8381538 DOI: 10.1073/Pnas.90.3.965 |
0.453 |
|
1993 |
Ninfa EG, Atkinson MR, Kamberov ES, Ninfa AJ. Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NR(II) or NtrB): trans-Phosphorylation between subunits Journal of Bacteriology. 175: 7024-7032. PMID 8226644 DOI: 10.1128/Jb.175.21.7024-7032.1993 |
0.408 |
|
1993 |
Atkinson MR, Ninfa AJ. Mutational analysis of the bacterial signal-transducing protein kinase/phosphatase nitrogen regulator II (NR(II) or NtrB) Journal of Bacteriology. 175: 7016-7023. PMID 7901195 DOI: 10.1128/Jb.175.21.7016-7023.1993 |
0.415 |
|
1992 |
Feng J, Atkinson MR, McCleary W, Stock JB, Wanner BL, Ninfa AJ. Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. Journal of Bacteriology. 174: 6061-70. PMID 1356964 DOI: 10.1128/Jb.174.19.6061-6070.1992 |
0.477 |
|
1992 |
Atkinson MR, Ninfa AJ. Characterization of Escherichia coli glnL mutations affecting nitrogen regulation Journal of Bacteriology. 174: 4538-4548. PMID 1352516 DOI: 10.1128/Jb.174.14.4538-4548.1992 |
0.398 |
|
1992 |
Ernsting BR, Atkinson MR, Ninfa AJ, Matthews RG. Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. Journal of Bacteriology. 174: 1109-18. PMID 1346534 DOI: 10.1128/Jb.174.4.1109-1118.1992 |
0.474 |
|
1991 |
Ninfa AJ. Protein phosphorylation and the regulation of cellular processes by the homologous two-component regulatory systems of bacteria Genetic Engineering. 13: 39-72. PMID 1369339 DOI: 10.1007/978-1-4615-3760-1_2 |
0.496 |
|
1989 |
Weglenski P, Ninfa AJ, Ueno-Nishio S, Magasanik B. Mutations in the glnG gene of Escherichia coli that result in increased activity of nitrogen regulator I. Journal of Bacteriology. 171: 4479-85. PMID 2666403 DOI: 10.1128/Jb.171.8.4479-4485.1989 |
0.489 |
|
1989 |
Igo MM, Ninfa AJ, Silhavy TJ. A bacterial environmental sensor that functions as a protein kinase and stimulates transcriptional activation Genes & Development. 3: 598-605. PMID 2663643 DOI: 10.1101/Gad.3.5.598 |
0.484 |
|
1989 |
Ninfa AJ, Mullin DA, Ramakrishnan G, Newton A. Escherichia coli σ54 RNA polymerase recognizes Caulobacter crescentus flbG and flaN flagellar gene promoters in vitro Journal of Bacteriology. 171: 383-391. PMID 2644197 DOI: 10.1128/Jb.171.1.383-391.1989 |
0.36 |
|
1989 |
Igo MM, Ninfa AJ, Stock JB, Silhavy TJ. Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor. Genes & Development. 3: 1725-34. PMID 2558046 DOI: 10.1101/Gad.3.11.1725 |
0.426 |
|
1989 |
Stock JB, Ninfa AJ, Stock AM. Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiological Reviews. 53: 450-90. PMID 2556636 DOI: 10.1128/mr.53.4.450-490.1989 |
0.429 |
|
1988 |
Stock AM, Wylie DC, Mottonen JM, Lupas AN, Ninfa EG, Ninfa AJ, Schutt CE, Stock JB. Phosphoproteins involved in bacterial signal transduction. Cold Spring Harbor Symposia On Quantitative Biology. 53: 49-57. PMID 3076087 DOI: 10.1101/Sqb.1988.053.01.009 |
0.324 |
|
1988 |
Ninfa AJ, Ninfa EG, Lupas AN, Stock A, Magasanik B, Stock J. Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. Proceedings of the National Academy of Sciences of the United States of America. 85: 5492-6. PMID 3041412 DOI: 10.1073/Pnas.85.15.5492 |
0.532 |
|
1987 |
Ninfa AJ, Reitzer LJ, Magasanik B. Initiation of transcription at the bacterial glnAp2 promoter by purified E. coli components is facilitated by enhancers. Cell. 50: 1039-46. PMID 3304660 DOI: 10.1016/0092-8674(87)90170-X |
0.414 |
|
1986 |
Ninfa AJ, Ueno-Nishio S, Hunt TP, Robustell B, Magasanik B. Purification of nitrogen regulator II, the product of the glnL (ntrB) gene of Escherichia coli. Journal of Bacteriology. 168: 1002-4. PMID 3536843 DOI: 10.1128/Jb.168.2.1002-1004.1986 |
0.39 |
|
1986 |
Ninfa AJ, Magasanik B. Covalent modification of the glnG product, NRI, by the glnL product, NRII, regulates the transcription of the glnALG operon in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 83: 5909-13. PMID 2874557 DOI: 10.1073/Pnas.83.16.5909 |
0.404 |
|
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