Nicholas P. Farrell - Publications

Affiliations: 
Virginia Commonwealth University, Richmond, VA, United States 
Area:
Biochemistry
Website:
https://chemistry.vcu.edu/people/faculty/farrell.html

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Du Z, Qu Y, Farrell NP. Intramolecular platinum migration on a peptide in gas phase during collision-induced dissociation. Journal of Inorganic Biochemistry. 202: 110858. PMID 31689625 DOI: 10.1016/j.jinorgbio.2019.110858  0.52
2019 Stelling MP, Motta JM, Mashid M, Johnson WE, Pavão MS, Farrell NP. Metal ions and the extracellular matrix in tumor migration. The Febs Journal. 286: 2950-2964. PMID 31379111 DOI: 10.1111/febs.14986  0.48
2019 Gorle AK, Berners-Price SJ, Farrell NP. Biological relevance of interaction of platinum drugs with -donor ligands. Inorganica Chimica Acta. 495. PMID 31354168 DOI: 10.1016/j.ica.2019.118974  0.48
2019 Yang Y, Dong Z, Hu H, Peng J, Sheng Y, Tong Y, Yuan S, Li Z, Yang J, Wells T, Qu Y, Farrell NP, Liu Y. The facile and visualizable identification of broad-spectrum inhibitors of MDM2/p53 using co-expressed protein complexes. The Analyst. PMID 31089613 DOI: 10.1039/c9an00350a  0.52
2019 Gorle AK, Zhang J, Berners-Price SJ, Farrell NP. Influence of geometric isomerism on the binding of platinum anticancer agents with phospholipids. Dalton Transactions (Cambridge, England : 2003). PMID 31070627 DOI: 10.1039/c9dt00753a  0.48
2019 Gorle AK, Rajaratnam P, Chang CW, von Itzstein M, Berners-Price SJ, Farrell NP. Glycans as Ligands in Bioinorganic Chemistry. Probing the Interaction of a Trinuclear Platinum Anticancer Complex with Defined Monosaccharide Fragments of Heparan Sulfate. Inorganic Chemistry. PMID 30632736 DOI: 10.1021/acs.inorgchem.8b03035  0.48
2018 Gorle AK, Katner SJ, Johnson WE, Lee DE, Daniel AG, Ginsburg EP, von Itzstein M, Berners-Price SJ, Farrell NP. Substitution-Inert Polynuclear Platinum Complexes as Metalloshielding Agents for Heparan Sulfate. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29655185 DOI: 10.1002/chem.201706030  0.92
2018 Katner SJ, Johnson WE, Peterson EJ, Page P, Farrell NP. Comparison of Metal-Ammine Compounds Binding to DNA and Heparin. Glycans as Ligands in Bioinorganic Chemistry. Inorganic Chemistry. PMID 29473748 DOI: 10.1021/acs.inorgchem.7b03043  0.48
2018 Farrell NP, Gorle AK, Peterson EJ, Berners-Price SJ. Metalloglycomics. Metal Ions in Life Sciences. 18. PMID 29394023 DOI: 10.1515/9783110470734-010  0.48
2018 Gorle AK, Zhang J, Liu Q, Berners-Price SJ, Farrell NP. Structural factors affecting binding of platinum anticancer agents with phospholipids. Influence of charge and phosphate clamp formation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29341369 DOI: 10.1002/chem.201705822  0.48
2017 de Paiva REF, Du Z, Peterson EJ, Corbi PP, Farrell NP. Probing the HIV-1 NCp7 Nucleocapsid Protein with Site-Specific Gold(I)-Phosphine Complexes. Inorganic Chemistry. PMID 28937773 DOI: 10.1021/acs.inorgchem.7b01762  0.48
2017 Peterson EJ, Daniel AG, Katner SJ, Bohlmann L, Chang CW, Bezos A, Parish CR, von Itzstein M, Berners-Price SJ, Farrell NP. Antiangiogenic platinum through glycan targeting. Chemical Science. 8: 241-252. PMID 28451171 DOI: 10.1039/c6sc02515c  0.92
2016 Bernardes VH, Qu Y, Du Z, Beaton J, Vargas MD, Farrell NP. Interaction of the HIV NCp7 Protein with Platinum(II) and Gold(III) Complexes Containing Tridentate Ligands. Inorganic Chemistry. 55: 11396-11407. PMID 27934299 DOI: 10.1021/acs.inorgchem.6b01925  0.52
2016 Spell SR, Mangrum JB, Peterson EJ, Fabris D, Ptak R, Farrell NP. Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists. Chemical Communications (Cambridge, England). PMID 27858001 DOI: 10.1039/c6cc07970a  1
2016 Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, et al. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. Journal of Translational Medicine. 14: 46. PMID 26861698 DOI: 10.1186/s12967-016-0803-2  1
2016 Komeda S, Qu Y, Mangrum JB, Hegmans A, Williams LD, Farrell NP. The phosphate clamp as recognition motif in platinum-DNA interactions Inorganica Chimica Acta. DOI: 10.1016/j.ica.2016.04.052  1
2015 Stukova M, Hall MD, Tsotsoros SD, Madigan JP, Farrell NP, Gottesman MM. Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients. Journal of Inorganic Biochemistry. 149: 45-8. PMID 26021697 DOI: 10.1016/j.jinorgbio.2015.05.003  1
2015 Farrell NP. Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets Chemical Society Reviews. 44: 8773-8785. PMID 25951946 DOI: 10.1039/c5cs00201j  1
2015 Spell SR, Farrell NP. [Au(dien)(N-heterocycle)](3+): reactivity with biomolecules and zinc finger peptides. Inorganic Chemistry. 54: 79-86. PMID 25531886 DOI: 10.1021/ic501784n  1
2015 Tsotsoros SD, Qu Y, Farrell NP. The reaction of dichlorodiammineplatinum(II), [PtCl2(NH3)2], isomers with zinc fingers. Journal of Inorganic Biochemistry. 143: 117-22. PMID 25528679 DOI: 10.1016/j.jinorgbio.2014.12.003  1
2015 Qu Y, Kipping RG, Farrell NP. Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp Dalton Transactions. 44: 3563-3572. PMID 25524170 DOI: 10.1039/c4dt03237c  1
2015 Peterson EJ, Menon VR, Gatti L, Kipping R, Dewasinghe D, Perego P, Povirk LF, Farrell NP. Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction. Molecular Pharmaceutics. 12: 287-97. PMID 25407898 DOI: 10.1021/mp5006867  1
2015 Moniodis JJ, Thomas DS, Davies MS, Berners-Price SJ, Farrell NP. Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association. Dalton Transactions (Cambridge, England : 2003). 44: 3583-93. PMID 25407024 DOI: 10.1039/c4dt02942a  1
2014 Prisecaru A, Molphy Z, Kipping RG, Peterson EJ, Qu Y, Kellett A, Farrell NP. The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes. Nucleic Acids Research. 42: 13474-87. PMID 25414347 DOI: 10.1093/nar/gku1157  1
2014 Daniel AG, Farrell NP. The dynamics of zinc sites in proteins: electronic basis for coordination sphere expansion at structural sites. Metallomics : Integrated Biometal Science. 6: 2230-41. PMID 25329367 DOI: 10.1039/c4mt00213j  1
2014 Malina J, Farrell NP, Brabec V. Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity. Angewandte Chemie (International Ed. in English). 53: 12812-6. PMID 25256921 DOI: 10.1002/anie.201408012  1
2014 Cardoso CR, Lima MV, Cheleski J, Peterson EJ, Venâncio T, Farrell NP, Carlos RM. Luminescent ruthenium complexes for theranostic applications. Journal of Medicinal Chemistry. 57: 4906-15. PMID 24831959 DOI: 10.1021/jm5005946  1
2014 Ma ES, Daniel AG, Farrell NP. Dinuclear platinum complexes containing planar aromatic ligands to enhance stacking interactions with proteins. Chemmedchem. 9: 1155-60. PMID 24801050 DOI: 10.1002/cmdc.201402052  1
2014 Daniel AG, Peterson EJ, Farrell NP. The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3. Angewandte Chemie (International Ed. in English). 53: 4098-101. PMID 24643997 DOI: 10.1002/anie.201311114  1
2014 Mangrum JB, Engelmann BJ, Peterson EJ, Ryan JJ, Berners-Price SJ, Farrell NP. A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding. Chemical Communications (Cambridge, England). 50: 4056-8. PMID 24463939 DOI: 10.1039/c3cc49695c  1
2014 Malina J, Farrell NP, Brabec V. DNA condensing effects and sequence selectivity of DNA binding of antitumor noncovalent polynuclear platinum complexes. Inorganic Chemistry. 53: 1662-71. PMID 24428232 DOI: 10.1021/ic402796k  1
2014 Engelmann BJ, Ryan JJ, Farrell NP. Antidepressants and platinum drugs. Anticancer Research. 34: 509-16. PMID 24403509  1
2014 Spell SR, Farrell NP. Synthesis and properties of the first [Au(dien)(N-heterocycle)]3+ compounds. Inorganic Chemistry. 53: 30-2. PMID 24328316 DOI: 10.1021/ic402772j  1
2014 Tsotsoros SD, Bate AB, Dows MG, Spell SR, Bayse CA, Farrell NP. Modulation of the stacking interaction of MN4 (M=Pt, Pd, Au) complexes with tryptophan through N-heterocyclic ligands. Journal of Inorganic Biochemistry. 132: 2-5. PMID 24206773 DOI: 10.1016/j.jinorgbio.2013.09.020  1
2013 Menon VR, Peterson EJ, Valerie K, Farrell NP, Povirk LF. Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochemical Pharmacology. 86: 1708-20. PMID 24161784 DOI: 10.1016/j.bcp.2013.10.012  1
2013 Abbehausen C, Peterson EJ, de Paiva RE, Corbi PP, Formiga AL, Qu Y, Farrell NP. Gold(I)-phosphine-N-heterocycles: biological activity and specific (ligand) interactions on the C-terminal HIVNCp7 zinc finger. Inorganic Chemistry. 52: 11280-7. PMID 24063530 DOI: 10.1021/ic401535s  1
2013 Mangrum JB, Zgani I, Tsotsoros SD, Qu Y, Farrell NP. Zinc finger peptide cleavage by a dinuclear platinum compound. Chemical Communications (Cambridge, England). 49: 6986-8. PMID 23802199 DOI: 10.1039/c3cc44219e  1
2013 Wedlock LE, Kilburn MR, Liu R, Shaw JA, Berners-Price SJ, Farrell NP. NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound. Chemical Communications (Cambridge, England). 49: 6944-6. PMID 23687657 DOI: 10.1039/c3cc42098a  1
2013 Pinato O, Musetti C, Farrell NP, Sissi C. Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation. Journal of Inorganic Biochemistry. 122: 27-37. PMID 23435290 DOI: 10.1016/j.jinorgbio.2013.01.007  1
2013 Neves AP, Pereira MX, Peterson EJ, Kipping R, Vargas MD, Silva-Jr FP, Carneiro JW, Farrell NP. Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. Journal of Inorganic Biochemistry. 119: 54-64. PMID 23186648 DOI: 10.1016/j.jinorgbio.2012.10.007  1
2013 Ruhayel RA, Berners-Price SJ, Farrell NP. Competitive formation of both long-range 5'-5' and short-range antiparallel 3'-3' DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex. Dalton Transactions (Cambridge, England : 2003). 42: 3181-7. PMID 23165925 DOI: 10.1039/c2dt32079g  1
2012 Silva H, Frézard F, Peterson EJ, Kabolizadeh P, Ryan JJ, Farrell NP. Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum. Molecular Pharmaceutics. 9: 1795-802. PMID 22494465 DOI: 10.1021/mp300098t  1
2012 Ruhayel RA, Langner JS, Oke MJ, Berners-Price SJ, Zgani I, Farrell NP. Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers. Journal of the American Chemical Society. 134: 7135-46. PMID 22443454 DOI: 10.1021/ja301397h  1
2012 Murphy RF, Komlodi-Pasztor E, Robey R, Balis FM, Farrell NP, Fojo T. Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin. Cell Cycle (Georgetown, Tex.). 11: 963-73. PMID 22333583 DOI: 10.4161/cc.11.5.19447  1
2012 Quintal S, Viegas A, Erhardt S, Cabrita EJ, Farrell NP. Platinated DNA affects zinc finger conformation. Interaction of a platinated single-stranded oligonucleotide and the C-terminal zinc finger of nucleocapsid protein HIVNCp7. Biochemistry. 51: 1752-61. PMID 22303928 DOI: 10.1021/bi201834g  1
2012 Muchova T, Quintal SM, Farrell NP, Brabec V, Kasparkova J. Antitumor bifunctional dinuclear Pt(II) complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 239-45. PMID 21938443 DOI: 10.1007/s00775-011-0845-0  1
2012 Kabolizadeh P, Engelmann BJ, Pullen N, Stewart JK, Ryan JJ, Farrell NP. Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 123-32. PMID 21918844 DOI: 10.1007/s00775-011-0836-1  1
2012 Florian J, Kasparkova J, Farrell NP, Brabec V. Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt(II) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 187-96. PMID 21894503 DOI: 10.1007/s00775-011-0841-4  1
2012 Farrell NP. Progress in platinum-derived drug development Drugs of the Future. 37: 795-806. DOI: 10.1358/dof.2012.037.011.1830167  1
2012 De Paula QA, Tsotsoros SD, Qu Y, Bayse CA, Farrell NP. Platinum-nucleobase PtN 4 complexes as chemotypes for selective peptide reactions with biomolecules Inorganica Chimica Acta. 393: 222-229. DOI: 10.1016/j.ica.2012.07.014  1
2011 Demicheli C, Frézard F, Pereira FA, Santos DM, Mangrum JB, Farrell NP. Interaction of arsenite with a zinc finger CCHC peptide: evidence for formation of an As-Zn-peptide mixed complex. Journal of Inorganic Biochemistry. 105: 1753-8. PMID 22099473 DOI: 10.1016/j.jinorgbio.2011.09.023  1
2011 P Farrell N. Platinum formulations as anticancer drugs clinical and pre-clinical studies. Current Topics in Medicinal Chemistry. 11: 2623-31. PMID 22039867 DOI: 10.2174/156802611798040714  1
2011 Benedetti BT, Quintal S, Farrell NP. Modulation of drug activation profiles through carboxylate ligand modification in cytotoxic trans-platinum planar amine compounds. Dalton Transactions (Cambridge, England : 2003). 40: 10983-8. PMID 21918760 DOI: 10.1039/c1dt10964b  1
2011 Malina J, Farrell NP, Brabec V. DNA interstrand cross-links of an antitumor trinuclear platinum(II) complex: thermodynamic analysis and chemical probing. Chemistry, An Asian Journal. 6: 1566-74. PMID 21557487 DOI: 10.1002/asia.201000935  1
2011 Benedetti BT, Peterson EJ, Kabolizadeh P, Martínez A, Kipping R, Farrell NP. Effects of noncovalent platinum drug-protein interactions on drug efficacy: use of fluorescent conjugates as probes for drug metabolism. Molecular Pharmaceutics. 8: 940-8. PMID 21548575 DOI: 10.1021/mp2000583  1
2011 Musetti C, Nazarov AA, Farrell NP, Sissi C. DNA reactivity profile of trans-platinum planar amine derivatives. Chemmedchem. 6: 1283-90. PMID 21472991 DOI: 10.1002/cmdc.201100032  1
2011 Ruhayel RA, Zgani I, Berners-Price SJ, Farrell NP. Solution studies of dinuclear polyamine-linked platinum-based antitumour complexes. Dalton Transactions (Cambridge, England : 2003). 40: 4147-54. PMID 21384050 DOI: 10.1039/c1dt00001b  1
2011 Quintal SM, dePaula QA, Farrell NP. Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences. Metallomics : Integrated Biometal Science. 3: 121-39. PMID 21253649 DOI: 10.1039/c0mt00070a  1
2011 Malina J, Kasparkova J, Farrell NP, Brabec V. Walking of antitumor bifunctional trinuclear PtII complex on double-helical DNA. Nucleic Acids Research. 39: 720-8. PMID 20833634 DOI: 10.1093/nar/gkq803  1
2011 Komeda S, Moulaei T, Chikuma M, Odani A, Kipping R, Farrell NP, Williams LD. The phosphate clamp: a small and independent motif for nucleic acid backbone recognition. Nucleic Acids Research. 39: 325-36. PMID 20736180 DOI: 10.1093/nar/gkq723  1
2011 Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. International Journal of Cancer. 128: 787-96. PMID 20473884 DOI: 10.1002/ijc.25394  1
2010 Ruhayel RA, Corry B, Braun C, Thomas DS, Berners-Price SJ, Farrell NP. Determination of the kinetic profile of a dinuclear platinum anticancer complex in the presence of sulfate: introducing a new tool for the expedited analysis of 2D [(1)H,( 15)N] HSQC NMR spectra. Inorganic Chemistry. 49: 10815-9. PMID 21067174 DOI: 10.1021/ic100576k  1
2010 Shingu T, Chumbalkar VC, Gwak HS, Fujiwara K, Kondo S, Farrell NP, Bogler O. The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro-Oncology. 12: 1269-77. PMID 20713409 DOI: 10.1093/neuonc/noq095  1
2010 Mangrum JB, Farrell NP. Excursions in polynuclear platinum DNA binding. Chemical Communications (Cambridge, England). 46: 6640-50. PMID 20694266 DOI: 10.1039/c0cc01254h  1
2010 Montero EI, Zhang J, Moniodis JJ, Berners-Price SJ, Farrell NP. The trans influence in the modulation of platinum anticancer agent biology: the effect of nitrite leaving group on aquation, reactions with S-nucleophiles and DNA binding of dinuclear and trinuclear compounds. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 9175-85. PMID 20589847 DOI: 10.1002/chem.200903578  1
2010 Yacoub A, Liu R, Park MA, Hamed HA, Dash R, Schramm DN, Sarkar D, Dimitriev IP, Bell JK, Grant S, Farrell NP, Curiel DT, Fisher PB, Dent P. Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells. Molecular Pharmacology. 77: 298-310. PMID 19910452 DOI: 10.1124/mol.109.061820  1
2010 Zerzankova L, Suchankova T, Vrana O, Farrell NP, Brabec V, Kasparkova J. Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles. Biochemical Pharmacology. 79: 112-21. PMID 19682435 DOI: 10.1016/j.bcp.2009.08.009  1
2009 Aris SM, Farrell NP. Towards Antitumor Active trans-Platinum Compounds. European Journal of Inorganic Chemistry. 2009: 1293. PMID 20161688 DOI: 10.1002/ejic.200801118  1
2009 De Paula QA, Liu Q, Almaraz E, Denny JA, Mangrum JB, Bhuvanesh N, Darensbourg MY, Farrell NP. Reactions of palladium and gold complexes with zinc-thiolate chelates using electrospray mass spectrometry and X-ray diffraction: Molecular identification of [Pd(bme-dach)], [Au(bme-dach]+ and [ZnCl(bme-dach)]2Pd Dalton Transactions. 10896-10903. PMID 20023920 DOI: 10.1039/b917748p  1
2009 de Paula QA, Mangrum JB, Farrell NP. Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au). Journal of Inorganic Biochemistry. 103: 1347-54. PMID 19692125 DOI: 10.1016/j.jinorgbio.2009.07.002  1
2009 Ruhayel RA, Moniodis JJ, Yang X, Kasparkova J, Brabec V, Berners-Price SJ, Farrell NP. Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 9365-74. PMID 19691069 DOI: 10.1002/chem.200900958  1
2009 Qu Y, Tran MC, Farrell NP. Structural consequences of a 3'-->3' DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 14: 969-77. PMID 19415349 DOI: 10.1007/s00775-009-0509-5  1
2009 Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK. Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. Journal of Medicinal Chemistry. 52: 916-25. PMID 19170599 DOI: 10.1021/jm8013234  1
2009 Ribeiro SJL, Ferreira AMdC, Solomon EI, Farrell NP. Papers from invited speakers at the First Latin American Meeting on Biological Inorganic Chemistry - LABIC2008 Journal of Inorganic Biochemistry. 103: 1299. DOI: 10.1016/j.jinorgbio.2009.09.004  1
2009 Aris SM, Knott KM, Yang X, Gewirtz DA, Farrell NP. Modulation of transplanaramine platinum complex reactivity by systematic modification of carrier and leaving groups Inorganica Chimica Acta. 362: 929-934. DOI: 10.1016/j.ica.2008.01.025  1
2008 Anzellotti AI, Bayse CA, Farrell NP. Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan. Inorganic Chemistry. 47: 10425-31. PMID 18939818 DOI: 10.1021/ic801004a  1
2008 Demicheli C, Frézard F, Mangrum JB, Farrell NP. Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs. Chemical Communications (Cambridge, England). 4828-30. PMID 18830507 DOI: 10.1039/b809186b  1
2008 Anzellotti AI, Farrell NP. Zinc metalloproteins as medicinal targets. Chemical Society Reviews. 37: 1629-51. PMID 18648687 DOI: 10.1039/b617121b  1
2008 Almaraz E, De Paula QA, Liu Q, Reibenspies JH, Darensbourg MY, Farrell NP. Thiolate bridging and metal exchange in adducts of a zinc finger model and PtII complexes: Biomimetic studies of protein/Pt/DNA interactions Journal of the American Chemical Society. 130: 6272-6280. PMID 18422317 DOI: 10.1021/ja711254q  1
2008 Hegmans A, Kasparkova J, Vrana O, Kelland LR, Brabec V, Farrell NP. Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity. Journal of Medicinal Chemistry. 51: 2254-60. PMID 18338842 DOI: 10.1021/jm070813z  1
2008 Strukl JV, De Paula QA, Yang X, Qu Y, Farrell NP. Comparison of cis and trans-platinum mononucleobase compounds with DNA and protein models Australian Journal of Chemistry. 61: 694-699. DOI: 10.1071/CH08227  1
2007 Montero EI, Benedetti BT, Mangrum JB, Oehlsen MJ, Qu Y, Farrell NP. Pre-association of polynuclear platinum anticancer agents on a protein, human serum albumin. Implications for drug design. Dalton Transactions (Cambridge, England : 2003). 4938-42. PMID 17992278 DOI: 10.1039/b708433c  1
2007 Williams JW, Qu Y, Bulluss GH, Alvorado E, Farrell NP. Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand. Inorganic Chemistry. 46: 5820-2. PMID 17592835 DOI: 10.1021/ic700410y  1
2007 Mitchell C, Kabolizadeh P, Ryan J, Roberts JD, Yacoub A, Curiel DT, Fisher PB, Hagan MP, Farrell NP, Grant S, Dent P. Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. Molecular Pharmacology. 72: 704-14. PMID 17578896 DOI: 10.1124/mol.107.038406  1
2007 Aris SM, Gewirtz DA, Ryan JJ, Knott KM, Farrell NP. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochemical Pharmacology. 73: 1749-57. PMID 17418817 DOI: 10.1016/j.bcp.2007.02.013  1
2006 Komeda S, Moulaei T, Woods KK, Chikuma M, Farrell NP, Williams LD. A third mode of DNA binding: Phosphate clamps by a polynuclear platinum complex. Journal of the American Chemical Society. 128: 16092-103. PMID 17165762 DOI: 10.1021/ja062851y  1
2006 Billecke C, Finniss S, Tahash L, Miller C, Mikkelsen T, Farrell NP, Bögler O. Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma. Neuro-Oncology. 8: 215-26. PMID 16723633 DOI: 10.1215/15228517-2006-004  1
2006 Billecke C, Malik I, Movsisyan A, Sulghani S, Sharif A, Mikkelsen T, Farrell NP, Bögler O. Analysis of glioma cell platinum response by metacomparison of two-dimensional chromatographic proteome profiles. Molecular & Cellular Proteomics : McP. 5: 35-42. PMID 15951525 DOI: 10.1074/mcp.M500124-MCP200  1
2005 Harris AL, Yang X, Hegmans A, Povirk L, Ryan JJ, Kelland L, Farrell NP. Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge. Inorganic Chemistry. 44: 9598-600. PMID 16363817 DOI: 10.1021/ic051390z  1
2005 Ourliac-Garnier I, Elizondo-Riojas MA, Redon S, Farrell NP, Bombard S. Cross-links of quadruplex structures from human telomeric DNA by dinuclear platinum complexes show the flexibility of both structures. Biochemistry. 44: 10620-34. PMID 16060671 DOI: 10.1021/bi050144w  1
2004 Farrell NP. Preclinical perspectives on the use of platinum compounds in cancer chemotherapy. Seminars in Oncology. 31: 1-9. PMID 15726528 DOI: 10.1053/j.seminoncol.2004.11.004  1
2003 Qu Y, Scarsdale NJ, Tran MC, Farrell NP. Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 19-28. PMID 12459895 DOI: 10.1007/s00775-002-0383-x  1
1998 Skov KA, Adomat H, Farrell NP, Matthews JB. Assessment of toxicity of bis-platinum complexes in hypoxic and aerobic cells Anti-Cancer Drug Design. 13: 207-220. PMID 9595034  1
1994 Marples B, Adomat H, Billings PC, Farrell NP, Koch CJ, Skov KA. Recognition of platinum-induced DNA damage by nuclear proteins: Screening for mechanisms Anti-Cancer Drug Design. 9: 389-399. PMID 7945723  1
1993 Skov KA, Adomat H, Farrell NP. Radiosensitization by nickel lapachol International Journal of Radiation Biology. 64: 707-713. PMID 7903338 DOI: 10.1080/09553009314551951  1
1992 Kraker AJ, Hoeschele JD, Elliott WL, Showalter HD, Sercel AD, Farrell NP. Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups. Journal of Medicinal Chemistry. 35: 4526-32. PMID 1335074  1
1990 Skov KA, Adomat H, Chaplin DJ, Farrell NP. Toxicity of [PtCl2(NH3)L] in hypoxia; L=misonidazole or metronidazole Anti-Cancer Drug Design. 5: 121-128. PMID 2156514  1
1989 Roberts JD, van Houten B, Qu Y, Farrell NP. Interaction of novel bis(platinum) complexes with DNA Nucleic Acids Research. 17: 9719-9733. PMID 2690006 DOI: 10.1093/nar/17.23.9719  1
1988 Farrell NP, De Almeida SG, Skov KA. Bis(platinum) complexes containing two platinum cis-diammine units. Synthesis and initial DNA-binding studies Journal of the American Chemical Society. 110: 5018-5019.  1
1987 Skov KA, Farrell NP, Adomat H. Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: Radiosensitization and toxicity studies in vitro Radiation Research. 112: 273-282. PMID 3685256  1
1987 Skov KA, Adomat H, Konway DC, Farrell NP. Assessment of DNA binding of platinum-radiosensitizer complexes by inhibition of restriction enzymes Chemico-Biological Interactions. 62: 117-129. PMID 3036382 DOI: 10.1016/0009-2797(87)90084-6  1
Show low-probability matches.