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Smita S. Patel - Publications

Affiliations: 
1992-1999 Biochemistry Ohio State University, Columbus, Columbus, OH 
 1999- University of Medicine and Dentistry of New Jersey, Piscataway Township, New Jersey, United States 
Area:
Biochemistry
Website:
https://molbiosci.rutgers.edu/faculty-research/faculty/116-smita-patel
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Year Citation  Score
2023 Hsieh AH, Reardon SD, Munozvilla-Cabellon JH, Shen J, Patel SS, Mishanina TV. Expression and Purification of Recombinant Human Mitochondrial RNA Polymerase (POLRMT) and the Initiation Factors TFAM and TFB2M. Bio-Protocol. 13: e4892. PMID 38094251 DOI: 10.21769/BioProtoc.4892  0.344
2023 Lee KY, Craig C, Patel SS. Unraveling blunt-end RNA binding and ATPase-driven translocation activities of the RIG-I family helicase LGP2. Nucleic Acids Research. PMID 38015453 DOI: 10.1093/nar/gkad1106  0.321
2023 Singh A, Patel G, Patel SS. Twinkle-Catalyzed Toehold-Mediated DNA Strand Displacement Reaction. Journal of the American Chemical Society. PMID 37917930 DOI: 10.1021/jacs.3c04970  0.446
2023 Goovaerts Q, Shen J, De Wijngaert B, Basu U, Patel SS, Das K. Structures illustrate step-by-step mitochondrial transcription initiation. Nature. 622: 872-879. PMID 37821701 DOI: 10.1038/s41586-023-06643-y  0.397
2022 Johnson LC, Singh A, Patel SS. The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by Polymerase γ. The Journal of Biological Chemistry. 102797. PMID 36528058 DOI: 10.1016/j.jbc.2022.102797  0.503
2022 Reed BD, Meyer MJ, Abramzon V, Ad O, Ad O, Adcock P, Ahmad FR, Alppay G, Ball JA, Beach J, Belhachemi D, Bellofiore A, Bellos M, Beltrán JF, Betts A, ... ... Patel SS, et al. Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device. Science (New York, N.Y.). 378: 186-192. PMID 36227977 DOI: 10.1126/science.abo7651  0.701
2022 Singh A, Patel SS. Quantitative methods to study helicase, DNA polymerase, and exonuclease coupling during DNA replication. Methods in Enzymology. 672: 75-102. PMID 35934486 DOI: 10.1016/bs.mie.2022.03.011  0.486
2021 Martinez SE, Singh A, De Wijngaert B, Sultana S, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Patel SS, Das K. Assembly and Cryo-EM structure determination of yeast mitochondrial RNA polymerase initiation complex intermediates. Star Protocols. 2: 100431. PMID 33870232 DOI: 10.1016/j.xpro.2021.100431  0.823
2020 Basu U, Bostwick AM, Das K, Dittenhafer-Reed KE, Patel SS. Structure, mechanism, and regulation of mitochondrial DNA transcription initiation. The Journal of Biological Chemistry. 295: 18406-18425. PMID 33453843 DOI: 10.1074/jbc.REV120.011202  0.313
2020 De Wijngaert B, Sultana S, Singh A, Dharia C, Vanbuel H, Shen J, Vasilchuk D, Martinez SE, Kandiah E, Patel SS, Das K. Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase. Molecular Cell. PMID 33278362 DOI: 10.1016/j.molcel.2020.11.016  0.854
2020 Basu U, Bostwick AM, Das K, Dittenhafer-Reed KE, Patel SS. Structure, mechanism, and regulation of mitochondrial DNA transcription initiation. The Journal of Biological Chemistry. PMID 33127643 DOI: 10.1074/jbc.REV120.011202  0.313
2020 Sohn BK, Basu U, Lee SW, Cho H, Shen J, Deshpande A, Johnson LC, Das K, Patel SS, Kim H. The dynamic landscape of transcription initiation in yeast mitochondria. Nature Communications. 11: 4281. PMID 32855416 DOI: 10.1038/S41467-020-17793-2  0.805
2020 Bostwick AM, Moya GE, Senti ML, Basu U, Shen J, Patel SS, Dittenhafer-Reed KE. Phosphorylation of mitochondrial transcription factor B2 controls mitochondrial DNA binding and transcription. Biochemical and Biophysical Research Communications. PMID 32505352 DOI: 10.1016/J.Bbrc.2020.05.141  0.458
2020 Basu U, Mishra N, Farooqui M, Shen J, Johnson LC, Patel SS. The C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M are part of an auto-inhibitory mechanism that regulates DNA binding. The Journal of Biological Chemistry. PMID 32241911 DOI: 10.1074/Jbc.Ra120.013338  0.569
2020 Singh A, Pandey M, Nandakumar D, Raney KD, Yin YW, Patel SS. Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles. The Embo Journal. e103367. PMID 32037587 DOI: 10.15252/Embj.2019103367  0.848
2020 Basu U, Lee SW, Deshpande A, Shen J, Sohn BK, Cho H, Kim H, Patel SS. The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation. Nucleic Acids Research. PMID 31980825 DOI: 10.1093/Nar/Gkaa040  0.854
2020 Lee S, Sohn B, Basu U, Cho H, Shen J, Deshpande A, Patel SS, Kim H. Single-Molecule Study Reveals the Conformational Dynamics During Initiation-Elongation Transition in Mitochondrial Transcription Biophysical Journal. 118: 542a. DOI: 10.1016/J.Bpj.2019.11.2969  0.785
2019 Chang HW, Hsieh FK, Patel SS, Studitsky VM. Time-Resolved Analysis of Transcription through Chromatin. Methods (San Diego, Calif.). PMID 30707952 DOI: 10.1016/J.Ymeth.2019.01.016  0.435
2018 Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR. HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity. Nature Communications. 9: 5366. PMID 30560918 DOI: 10.1038/S41467-018-07780-Z  0.385
2018 Bird JG, Basu U, Kuster D, Ramachandran A, Grudzien-Nogalska E, Towheed A, Wallace DC, Kiledjian M, Temiakov D, Patel SS, Ebright RH, Nickels BE. Highly efficient 5' capping of mitochondrial RNA with NAD and NADH by yeast and human mitochondrial RNA polymerase. Elife. 7. PMID 30526856 DOI: 10.7554/Elife.42179  0.417
2018 Devarkar SC, Schweibenz B, Wang C, Marcotrigiano J, Patel SS. RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization. Molecular Cell. PMID 30270105 DOI: 10.1016/J.Molcel.2018.08.021  0.464
2018 Sun B, Singh A, Sultana S, Inman JT, Patel SS, Wang MD. Helicase promotes replication re-initiation from an RNA transcript. Nature Communications. 9: 2306. PMID 29899338 DOI: 10.1038/S41467-018-04702-X  0.863
2018 Koh HR, Roy R, Sorokina M, Tang GQ, Nandakumar D, Patel SS, Ha T. Correlating Transcription Initiation and Conformational Changes by a Single-Subunit RNA Polymerase with Near Base-Pair Resolution. Molecular Cell. 70: 695-706.e5. PMID 29775583 DOI: 10.1016/J.Molcel.2018.04.018  0.801
2018 Bird JG, Basu U, Kuster D, Ramachandran A, Grudzien-Nogalska E, Towheed A, Wallace DC, Kiledjian M, Temiakov D, Patel SS, Ebright RH, Nickels BE. Author response: Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase Elife. DOI: 10.7554/Elife.42179.023  0.374
2017 Sultana S, Solotchi M, Ramachandran A, Patel SS. Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and Phage T7 single-subunit RNA polymerases. The Journal of Biological Chemistry. PMID 28882896 DOI: 10.1074/Jbc.M117.797480  0.818
2017 Brennan LD, Forties RA, Patel SS, Wang MD. DNA Looping Mediates Nucleosome Transfer Biophysical Journal. 112: 513a. DOI: 10.1016/j.bpj.2016.11.2774  0.366
2016 Ramachandran A, Basu U, Sultana S, Nandakumar D, Patel SS. Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation. Nucleic Acids Research. PMID 27903899 DOI: 10.1093/Nar/Gkw1157  0.816
2016 Chang HW, Pandey M, Kulaeva OI, Patel SS, Studitsky VM. Overcoming a nucleosomal barrier to replication. Science Advances. 2: e1601865. PMID 27847876 DOI: 10.1126/Sciadv.1601865  0.821
2016 Brennan LD, Forties RA, Patel SS, Wang MD. DNA looping mediates nucleosome transfer. Nature Communications. 7: 13337. PMID 27808093 DOI: 10.1038/Ncomms13337  0.467
2016 Ramachandran A, Nandakumar D, Deshpande A, Lucas TP, Bhojappa RR, Tang GQ, Raney K, Yin YW, Patel SS. The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA. The Journal of Biological Chemistry. PMID 27311715 DOI: 10.1074/Jbc.M116.740282  0.855
2016 Nandakumar D, Patel SS. Methods to study the coupling between replicative helicase and leading-strand DNA polymerase at the replication fork. Methods (San Diego, Calif.). PMID 27173619 DOI: 10.1016/J.Ymeth.2016.05.003  0.842
2016 Sen D, Patel G, Patel SS. Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE. Nucleic Acids Research. PMID 26887820 DOI: 10.1093/Nar/Gkw098  0.569
2016 Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J. Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proceedings of the National Academy of Sciences of the United States of America. PMID 26733676 DOI: 10.1073/Pnas.1515152113  0.689
2015 Sun B, Pandey M, Inman JT, Yang Y, Kashlev M, Patel SS, Wang MD. T7 replisome directly overcomes DNA damage. Nature Communications. 6: 10260. PMID 26675048 DOI: 10.1038/Ncomms10260  0.786
2015 Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection. Nucleic Acids Research. PMID 26612866 DOI: 10.1093/Nar/Gkv1299  0.69
2015 Szymanski MR, Kuznetsov VB, Shumate C, Meng Q, Lee YS, Patel G, Patel S, Yin YW. Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase. The Embo Journal. 34: 1959-70. PMID 26056153 DOI: 10.15252/Embj.201591520  0.514
2015 Pandey M, Elshenawy MM, Jergic S, Takahashi M, Dixon NE, Hamdan SM, Patel SS. Two mechanisms coordinate replication termination by the Escherichia coli Tus-Ter complex. Nucleic Acids Research. PMID 26007657 DOI: 10.1093/Nar/Gkv527  0.8
2015 Nandakumar D, Pandey M, Patel SS. Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other. Elife. 4. PMID 25970034 DOI: 10.7554/Elife.06562  0.846
2015 Nandakumar D, Patel SS. Finding the right match fast. Cell. 160: 809-11. PMID 25723158 DOI: 10.1016/J.Cell.2015.02.007  0.76
2015 Nandakumar D, Pandey M, Patel SS. Author response: Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other Elife. DOI: 10.7554/Elife.06562.022  0.786
2014 Deshpande AP, Patel SS. Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency. Nucleic Acids Research. 42: 11721-32. PMID 25249624 DOI: 10.1093/Nar/Gku868  0.813
2014 Deshpande AP, Sultana S, Patel SS. Fluorescent methods to study transcription initiation and transition into elongation. Exs. 105: 105-30. PMID 25095993 DOI: 10.1007/978-3-0348-0856-9_6  0.832
2014 Tang GQ, Nandakumar D, Bandwar RP, Lee KS, Roy R, Ha T, Patel SS. Relaxed rotational and scrunching changes in P266L mutant of T7 RNA polymerase reduce short abortive RNAs while delaying transition into elongation. Plos One. 9: e91859. PMID 24651161 DOI: 10.1371/Journal.Pone.0091859  0.818
2014 Pandey M, Patel SS. Helicase and polymerase move together close to the fork junction and copy DNA in one-nucleotide steps. Cell Reports. 6: 1129-38. PMID 24630996 DOI: 10.1016/J.Celrep.2014.02.025  0.835
2014 Syed S, Pandey M, Patel SS, Ha T. Single-molecule fluorescence reveals the unwinding stepping mechanism of replicative helicase. Cell Reports. 6: 1037-45. PMID 24630993 DOI: 10.1016/J.Celrep.2014.02.022  0.806
2014 Sun B, Inman JT, Smith BY, Yang Y, Patel SS, Wang MD. Replicative Helicase Assists DNA Polymerase in Bypassing a Lesion Biophysical Journal. 106: 272a. DOI: 10.1016/J.Bpj.2013.11.1592  0.404
2013 Hsieh FK, Kulaeva OI, Patel SS, Dyer PN, Luger K, Reinberg D, Studitsky VM. Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proceedings of the National Academy of Sciences of the United States of America. 110: 7654-9. PMID 23610384 DOI: 10.1073/Pnas.1222198110  0.431
2013 Ramanagoudr-Bhojappa R, Chib S, Byrd AK, Aarattuthodiyil S, Pandey M, Patel SS, Raney KD. Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA. The Journal of Biological Chemistry. 288: 16185-95. PMID 23596008 DOI: 10.1074/Jbc.M113.470013  0.815
2013 Jeong YJ, Rajagopal V, Patel SS. Switching from single-stranded to double-stranded DNA limits the unwinding processivity of ring-shaped T7 DNA helicase. Nucleic Acids Research. 41: 4219-29. PMID 23446275 DOI: 10.1093/Nar/Gkt133  0.569
2013 Pandey M, Patel SS. Coupling of Hexameric Helicase and DNA Polymerase in T7 Replisome during DNA Replication Biophysical Journal. 104: 368a. DOI: 10.1016/J.Bpj.2012.11.2045  0.831
2012 Sen D, Nandakumar D, Tang GQ, Patel SS. Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase. The Journal of Biological Chemistry. 287: 14545-56. PMID 22383523 DOI: 10.1074/Jbc.M111.309468  0.845
2012 Deshpande AP, Patel SS. Mechanism of transcription initiation by the yeast mitochondrial RNA polymerase. Biochimica Et Biophysica Acta. 1819: 930-8. PMID 22353467 DOI: 10.1016/J.Bbagrm.2012.02.003  0.814
2012 Kim H, Tang GQ, Patel SS, Ha T. Opening-closing dynamics of the mitochondrial transcription pre-initiation complex. Nucleic Acids Research. 40: 371-80. PMID 21911357 DOI: 10.1093/Nar/Gkr736  0.493
2011 Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M, Patel SS, Marcotrigiano J. Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature. 479: 423-7. PMID 21947008 DOI: 10.1038/Nature10537  0.719
2011 Sun B, Johnson DS, Patel G, Smith BY, Pandey M, Patel SS, Wang MD. ATP-induced helicase slippage reveals highly coordinated subunits. Nature. 478: 132-5. PMID 21927003 DOI: 10.1038/Nature10409  0.825
2011 Tang GQ, Deshpande AP, Patel SS. Transcription factor-dependent DNA bending governs promoter recognition by the mitochondrial RNA polymerase. The Journal of Biological Chemistry. 286: 38805-13. PMID 21911502 DOI: 10.1074/Jbc.M111.261966  0.85
2011 Patel SS, Pandey M, Nandakumar D. Dynamic coupling between the motors of DNA replication: hexameric helicase, DNA polymerase, and primase. Current Opinion in Chemical Biology. 15: 595-605. PMID 21865075 DOI: 10.1016/J.Cbpa.2011.08.003  0.839
2011 Forth S, Deufel C, Patel SS, Wang MD. Direct measurements of torque during Holliday junction migration. Biophysical Journal. 101: L5-7. PMID 21767475 DOI: 10.1016/J.Bpj.2011.05.066  0.445
2011 Patel G, Johnson DS, Sun B, Pandey M, Yu X, Egelman EH, Wang MD, Patel SS. A257T linker region mutant of T7 helicase-primase protein is defective in DNA loading and rescued by T7 DNA polymerase. The Journal of Biological Chemistry. 286: 20490-9. PMID 21515672 DOI: 10.1074/Jbc.M110.201657  0.82
2011 Paratkar S, Deshpande AP, Tang GQ, Patel SS. The N-terminal domain of the yeast mitochondrial RNA polymerase regulates multiple steps of transcription. The Journal of Biological Chemistry. 286: 16109-20. PMID 21454631 DOI: 10.1074/Jbc.M111.228023  0.824
2011 Tang GQ, Anand VS, Patel SS. Fluorescence-based assay to measure the real-time kinetics of nucleotide incorporation during transcription elongation. Journal of Molecular Biology. 405: 666-78. PMID 21035457 DOI: 10.1016/J.Jmb.2010.10.020  0.465
2011 Kim H, Tang G, Patel SS, Ha T. Promoter Opening-Closing Dynamics of Mitochondrial RNA Polymerase Biophysical Journal. 100: 65a. DOI: 10.1016/J.Bpj.2010.12.555  0.553
2010 Patel SS. One motor driving two translocases. Nature Structural & Molecular Biology. 17: 1166-7. PMID 20924403 DOI: 10.1038/Nsmb1010-1166  0.449
2010 Rajagopal V, Gurjar M, Levin MK, Patel SS. The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase. The Journal of Biological Chemistry. 285: 17821-32. PMID 20363755 DOI: 10.1074/Jbc.M110.114785  0.478
2010 Pandey M, Levin MK, Patel SS. Experimental and computational analysis of DNA unwinding and polymerization kinetics. Methods in Molecular Biology (Clifton, N.J.). 587: 57-83. PMID 20225142 DOI: 10.1007/978-1-60327-355-8_5  0.776
2010 Paratkar S, Patel SS. Mitochondrial transcription factor Mtf1 traps the unwound non-template strand to facilitate open complex formation. The Journal of Biological Chemistry. 285: 3949-56. PMID 20008320 DOI: 10.1074/Jbc.M109.050732  0.582
2010 Syed S, Pandey M, Patel SS, Ha T. Stepping Mechanism of Bacteriophage T7 Helicase and Priming Loop Observed Using Single-Molecule Fret Methods Biophysical Journal. 98: 66a. DOI: 10.1016/J.Bpj.2009.12.376  0.818
2010 Sen D, Patel S. A Closer Look At the Unwinding Initiation By Twinkle-The Human Mitochondrial DNA Helicase Biophysical Journal. 98: 66a. DOI: 10.1016/J.Bpj.2009.12.375  0.525
2009 Tang GQ, Roy R, Bandwar RP, Ha T, Patel SS. Real-time observation of the transition from transcription initiation to elongation of the RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 106: 22175-80. PMID 20018723 DOI: 10.1073/Pnas.0906979106  0.482
2009 Patel SS. Structural biology: Steps in the right direction. Nature. 462: 581-3. PMID 19956250 DOI: 10.1038/462581A  0.377
2009 Pandey M, Syed S, Donmez I, Patel G, Ha T, Patel SS. Coordinating DNA replication by means of priming loop and differential synthesis rate. Nature. 462: 940-3. PMID 19924126 DOI: 10.1038/Nature08611  0.835
2009 Sorokina M, Koh HR, Patel SS, Ha T. Fluorescent lifetime trajectories of a single fluorophore reveal reaction intermediates during transcription initiation. Journal of the American Chemical Society. 131: 9630-1. PMID 19552410 DOI: 10.1021/Ja902861F  0.376
2009 Levin MK, Hingorani MM, Holmes RM, Patel SS, Carson JH. Model-based global analysis of heterogeneous experimental data using gfit. Methods in Molecular Biology (Clifton, N.J.). 500: 335-59. PMID 19399438 DOI: 10.1007/978-1-59745-525-1_12  0.585
2009 Tang GQ, Paratkar S, Patel SS. Fluorescence mapping of the open complex of yeast mitochondrial RNA polymerase. The Journal of Biological Chemistry. 284: 5514-22. PMID 19116203 DOI: 10.1074/Jbc.M807880200  0.559
2009 Tang GQ, Paratkar S, Patel S. Erratum: Flourescence mapping of the open complex of yeast mitochondrial RNA polymerase (Journal of Biological Chemistry (2009) vol. 284 (5514-5522)) Journal of Biological Chemistry. 284. DOI: 10.1074/Jbc.A807880200  0.369
2009 Tang G, Paratkar S, Patel SS. Characterization of The Open Complex of Yeast Mitochondrial RNA Polymerase Biophysical Journal. 96: 56a. DOI: 10.1016/J.Bpj.2008.12.187  0.602
2009 Patel S, Pandey M, Syed S, Ha T, Johnson D, Wang M. Coupling of two motors: T7 helicase-primase and DNA polymerase Biophysical Journal. 96: 193a. DOI: 10.1016/J.Bpj.2008.12.1032  0.82
2009 Patel SS. Submerged DNA Archaeology. 62: 24.  0.415
2008 Tang GQ, Roy R, Ha T, Patel SS. Transcription initiation in a single-subunit RNA polymerase proceeds through DNA scrunching and rotation of the N-terminal subdomains. Molecular Cell. 30: 567-77. PMID 18538655 DOI: 10.1016/J.Molcel.2008.04.003  0.583
2008 Rasnik I, Jeong YJ, McKinney SA, Rajagopal V, Patel SS, Ha T. Branch migration enzyme as a Brownian ratchet. The Embo Journal. 27: 1727-35. PMID 18511910 DOI: 10.1038/Emboj.2008.106  0.463
2008 Donmez I, Patel SS. Coupling of DNA unwinding to nucleotide hydrolysis in a ring-shaped helicase. The Embo Journal. 27: 1718-26. PMID 18497749 DOI: 10.1038/Emboj.2008.100  0.543
2008 Liu SW, Rajagopal V, Patel SS, Kiledjian M. Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme. The Journal of Biological Chemistry. 283: 16427-36. PMID 18441014 DOI: 10.1074/Jbc.M800341200  0.369
2008 Pandey M, Patel SS, Gabriel A. Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase. Plos One. 3: e1389. PMID 18167548 DOI: 10.1371/Journal.Pone.0001389  0.753
2008 Rajagopal V, Patel SS. Single strand binding proteins increase the processivity of DNA unwinding by the hepatitis C virus helicase. Journal of Molecular Biology. 376: 69-79. PMID 18155046 DOI: 10.1016/J.Jmb.2007.10.070  0.491
2008 Guhaniyogi J, Wu T, Patel SS, Stock AM. Interaction of CheY with the C-terminal peptide of CheZ. Journal of Bacteriology. 190: 1419-28. PMID 18083806 DOI: 10.1128/Jb.01414-07  0.318
2007 Johnson DS, Bai L, Smith BY, Patel SS, Wang MD. Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase. Cell. 129: 1299-309. PMID 17604719 DOI: 10.1016/J.Cell.2007.04.038  0.554
2007 Bandwar RP, Ma N, Emanuel SA, Anikin M, Vassylyev DG, Patel SS, McAllister WT. The transition to an elongation complex by T7 RNA polymerase is a multistep process. The Journal of Biological Chemistry. 282: 22879-86. PMID 17548349 DOI: 10.1074/Jbc.M702589200  0.439
2007 Donmez I, Rajagopal V, Jeong YJ, Patel SS. Nucleic acid unwinding by hepatitis C virus and bacteriophage t7 helicases is sensitive to base pair stability. The Journal of Biological Chemistry. 282: 21116-23. PMID 17504766 DOI: 10.1074/Jbc.M702136200  0.434
2007 Singh K, Srivastava A, Patel SS, Modak MJ. Participation of the fingers subdomain of Escherichia coli DNA polymerase I in the strand displacement synthesis of DNA. The Journal of Biological Chemistry. 282: 10594-604. PMID 17259182 DOI: 10.1074/Jbc.M611242200  0.583
2007 Picha KM, Patel SS, Mandiyan S, Koehn J, Wennogle LP. The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. The Journal of Biological Chemistry. 282: 2911-7. PMID 17135270 DOI: 10.1074/Jbc.M610096200  0.714
2006 Anand VS, Patel SS. Transient state kinetics of transcription elongation by T7 RNA polymerase. The Journal of Biological Chemistry. 281: 35677-85. PMID 17005565 DOI: 10.1074/Jbc.M608180200  0.503
2006 Donmez I, Patel SS. Mechanisms of a ring shaped helicase. Nucleic Acids Research. 34: 4216-24. PMID 16935879 DOI: 10.1093/Nar/Gkl508  0.566
2006 Bandwar RP, Tang GQ, Patel SS. Sequential release of promoter contacts during transcription initiation to elongation transition. Journal of Molecular Biology. 360: 466-83. PMID 16780876 DOI: 10.1016/J.Jmb.2006.05.029  0.436
2006 Adelman JL, Jeong YJ, Liao JC, Patel G, Kim DE, Oster G, Patel SS. Mechanochemistry of transcription termination factor Rho. Molecular Cell. 22: 611-21. PMID 16762834 DOI: 10.1016/J.Molcel.2006.04.022  0.431
2006 Tang GQ, Patel SS. Rapid binding of T7 RNA polymerase is followed by simultaneous bending and opening of the promoter DNA. Biochemistry. 45: 4947-56. PMID 16605262 DOI: 10.1021/Bi052292S  0.573
2006 Tang GQ, Patel SS. T7 RNA polymerase-induced bending of promoter DNA is coupled to DNA opening. Biochemistry. 45: 4936-46. PMID 16605261 DOI: 10.1021/Bi0522910  0.584
2005 Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. The Journal of Biological Chemistry. 280: 41789-92. PMID 16263726 DOI: 10.1074/Jbc.C500395200  0.315
2005 Tang GQ, Bandwar RP, Patel SS. Extended upstream A-T sequence increases T7 promoter strength. The Journal of Biological Chemistry. 280: 40707-13. PMID 16215231 DOI: 10.1074/Jbc.M508013200  0.502
2005 Liao JC, Jeong YJ, Kim DE, Patel SS, Oster G. Mechanochemistry of t7 DNA helicase. Journal of Molecular Biology. 350: 452-75. PMID 15950239 DOI: 10.1016/J.Jmb.2005.04.051  0.572
2005 Stano NM, Jeong YJ, Donmez I, Tummalapalli P, Levin MK, Patel SS. DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase. Nature. 435: 370-3. PMID 15902262 DOI: 10.1038/Nature03615  0.581
2005 Levin MK, Gurjar M, Patel SS. A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase. Nature Structural & Molecular Biology. 12: 429-35. PMID 15806107 DOI: 10.1038/Nsmb920  0.403
2004 Pandey M, Patel S, Gabriel A. Insights into the role of an active site aspartate in Ty1 reverse transcriptase polymerization. The Journal of Biological Chemistry. 279: 47840-8. PMID 15333632 DOI: 10.1074/Jbc.M406019200  0.779
2004 Jeong YJ, Levin MK, Patel SS. The DNA-unwinding mechanism of the ring helicase of bacteriophage T7. Proceedings of the National Academy of Sciences of the United States of America. 101: 7264-9. PMID 15123793 DOI: 10.1073/Pnas.0400372101  0.565
2004 Levin MK, Wang YH, Patel SS. The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity. The Journal of Biological Chemistry. 279: 26005-12. PMID 15087464 DOI: 10.1074/Jbc.M403257200  0.475
2004 Jeong YJ, Kim DE, Patel SS. Nucleotide binding induces conformational changes in Escherichia coli transcription termination factor Rho. The Journal of Biological Chemistry. 279: 18370-6. PMID 14970217 DOI: 10.1074/Jbc.M309162200  0.484
2004 Stano NM, Patel SS. T7 lysozyme represses T7 RNA polymerase transcription by destabilizing the open complex during initiation. The Journal of Biological Chemistry. 279: 16136-43. PMID 14764584 DOI: 10.1074/Jbc.M400139200  0.486
2003 Patel SS, Bandwar RP. Fluorescence methods for studying the kinetics and thermodynamics of transcription initiation. Methods in Enzymology. 370: 668-86. PMID 14712683 DOI: 10.1016/S0076-6879(03)70055-X  0.415
2003 Liu M, Gupte G, Roy S, Bandwar RP, Patel SS, Garges S. Kinetics of transcription initiation at lacP1. Multiple roles of cyclic AMP receptor protein. The Journal of Biological Chemistry. 278: 39755-61. PMID 12881519 DOI: 10.1074/Jbc.M305995200  0.476
2003 Levin MK, Gurjar MM, Patel SS. ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase. The Journal of Biological Chemistry. 278: 23311-6. PMID 12660239 DOI: 10.1074/Jbc.M301283200  0.38
2002 Bandwar RP, Patel SS. The energetics of consensus promoter opening by T7 RNA polymerase. Journal of Molecular Biology. 324: 63-72. PMID 12421559 DOI: 10.1016/S0022-2836(02)01034-3  0.526
2002 Jeong YJ, Kim DE, Patel SS. Kinetic pathway of dTTP hydrolysis by hexameric T7 helicase-primase in the absence of DNA. The Journal of Biological Chemistry. 277: 43778-84. PMID 12226105 DOI: 10.1074/Jbc.M208634200  0.459
2002 Kim DE, Narayan M, Patel SS. T7 DNA helicase: a molecular motor that processively and unidirectionally translocates along single-stranded DNA. Journal of Molecular Biology. 321: 807-19. PMID 12206763 DOI: 10.1016/S0022-2836(02)00733-7  0.53
2002 Stano NM, Levin MK, Patel SS. The +2 NTP binding drives open complex formation in T7 RNA polymerase. The Journal of Biological Chemistry. 277: 37292-300. PMID 12151383 DOI: 10.1074/Jbc.M201600200  0.495
2002 Levin MK, Patel SS. Helicase from hepatitis C virus, energetics of DNA binding. The Journal of Biological Chemistry. 277: 29377-85. PMID 12034714 DOI: 10.1074/Jbc.M112315200  0.527
2002 Bandwar RP, Jia Y, Stano NM, Patel SS. Kinetic and thermodynamic basis of promoter strength: multiple steps of transcription initiation by T7 RNA polymerase are modulated by the promoter sequence. Biochemistry. 41: 3586-95. PMID 11888274 DOI: 10.1021/Bi0158472  0.76
2002 Stano NM, Patel SS. The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis. Journal of Molecular Biology. 315: 1009-25. PMID 11827472 DOI: 10.1006/Jmbi.2001.5313  0.584
2001 VanLoock MS, Chen YJ, Yu X, Patel SS, Egelman EH. The primase active site is on the outside of the hexameric bacteriophage T7 gene 4 helicase-primase ring. Journal of Molecular Biology. 311: 951-6. PMID 11531331 DOI: 10.1006/Jmbi.2001.4932  0.531
2001 Bandwar RP, Patel SS. Peculiar 2-aminopurine fluorescence monitors the dynamics of open complex formation by bacteriophage T7 RNA polymerase. The Journal of Biological Chemistry. 276: 14075-82. PMID 11278877 DOI: 10.1074/Jbc.M011289200  0.501
2001 Kim DE, Patel SS. The kinetic pathway of RNA binding to the Escherichia coli transcription termination factor Rho. The Journal of Biological Chemistry. 276: 13902-10. PMID 11278821 DOI: 10.1074/Jbc.M011043200  0.449
2001 Bandwar RP, Patel SS. Peculiar 2-Aminopurine Fluorescence Monitors the Dynamics of Open Complex Formation by Bacteriophage T7 RNA Polymerase Journal of Biological Chemistry. 276: 17075-17082.  0.406
2000 Patel SS, Picha KM. Structure and function of hexameric helicases. Annual Review of Biochemistry. 69: 651-97. PMID 10966472 DOI: 10.1146/annurev.biochem.69.1.651  0.801
2000 Ahnert P, Picha KM, Patel SS. A ring-opening mechanism for DNA binding in the central channel of the T7 helicase-primase protein. The Embo Journal. 19: 3418-27. PMID 10880454 DOI: 10.1093/Emboj/19.13.3418  0.842
2000 Picha KM, Ahnert P, Patel SS. DNA binding in the central channel of bacteriophage T7 helicase-primase is a multistep process. Nucleotide hydrolysis is not required. Biochemistry. 39: 6401-9. PMID 10828954 DOI: 10.1021/Bi992857I  0.845
1999 Kim DE, Patel SS. The mechanism of ATP hydrolysis at the noncatalytic sites of the transcription termination factor Rho. The Journal of Biological Chemistry. 274: 32667-71. PMID 10551822 DOI: 10.1074/Jbc.274.46.32667  0.375
1999 Kim DE, Shigesada K, Patel SS. Transcription termination factor Rho contains three noncatalytic nucleotide binding sites. The Journal of Biological Chemistry. 274: 11623-8. PMID 10206972 DOI: 10.1074/Jbc.274.17.11623  0.424
1998 Picha KM, Patel SS. Bacteriophage T7 DNA helicase binds dTTP, forms hexamers, and binds DNA in the absence of Mg2+. The presence of dTTP is sufficient for hexamer formation and DNA binding. The Journal of Biological Chemistry. 273: 27315-9. PMID 9765257 DOI: 10.1074/Jbc.273.42.27315  0.8
1998 Washington MT, Patel SS. Increased DNA unwinding efficiency of bacteriophage T7 DNA helicase mutant protein 4A'/E348K. The Journal of Biological Chemistry. 273: 7880-7. PMID 9525882 DOI: 10.1074/Jbc.273.14.7880  0.712
1998 Zhong X, Patel SS, Tsai MD. DNA polymerase β. 5. Dissecting the functional roles of the two metal ions with Cr(III)dTTP Journal of the American Chemical Society. 120: 235-236. DOI: 10.1021/Ja973507R  0.443
1997 Ahnert P, Patel SS. Asymmetric interactions of hexameric bacteriophage T7 DNA helicase with the 5'- and 3'-tails of the forked DNA substrate. The Journal of Biological Chemistry. 272: 32267-73. PMID 9405431 DOI: 10.1074/Jbc.272.51.32267  0.757
1997 Kumar A, Patel SS. Inhibition of T7 RNA polymerase: transcription initiation and transition from initiation to elongation are inhibited by T7 lysozyme via a ternary complex with RNA polymerase and promoter DNA. Biochemistry. 36: 13954-62. PMID 9374875 DOI: 10.1021/Bi971432Y  0.553
1997 Jia Y, Patel SS. Kinetic mechanism of GTP binding and RNA synthesis during transcription initiation by bacteriophage T7 RNA polymerase. The Journal of Biological Chemistry. 272: 30147-53. PMID 9374495 DOI: 10.1074/Jbc.272.48.30147  0.798
1997 Zhong X, Patel SS, Werneburg BG, Tsai MD. DNA polymerase beta: multiple conformational changes in the mechanism of catalysis. Biochemistry. 36: 11891-900. PMID 9305982 DOI: 10.1021/Bi963181J  0.411
1997 Hingorani MM, Washington MT, Moore KC, Patel SS. The dTTPase mechanism of T7 DNA helicase resembles the binding change mechanism of the F1-ATPase. Proceedings of the National Academy of Sciences of the United States of America. 94: 5012-7. PMID 9144181 DOI: 10.1073/Pnas.94.10.5012  0.801
1997 Jia Y, Patel SS. Kinetic mechanism of transcription initiation by bacteriophage T7 RNA polymerase. Biochemistry. 36: 4223-32. PMID 9100017 DOI: 10.1021/Bi9630467  0.75
1996 Jia Y, Kumar A, Patel SS. Equilibrium and stopped-flow kinetic studies of interaction between T7 RNA polymerase and its promoters measured by protein and 2-aminopurine fluorescence changes. The Journal of Biological Chemistry. 271: 30451-8. PMID 8940010 DOI: 10.1074/Jbc.271.48.30451  0.8
1996 Washington MT, Rosenberg AH, Griffin K, Studier FW, Patel SS. Biochemical analysis of mutant T7 primase/helicase proteins defective in DNA binding, nucleotide hydrolysis, and the coupling of hydrolysis with DNA unwinding. The Journal of Biological Chemistry. 271: 26825-34. PMID 8900164 DOI: 10.1074/Jbc.271.43.26825  0.682
1996 Rosenberg AH, Griffin K, Washington MT, Patel SS, Studier FW. Selection, identification, and genetic analysis of random mutants in the cloned primase/helicase gene of bacteriophage T7. The Journal of Biological Chemistry. 271: 26819-24. PMID 8900163 DOI: 10.1074/Jbc.271.43.26819  0.575
1996 Yu X, Hingorani MM, Patel SS, Egelman EH. DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase. Nature Structural Biology. 3: 740-3. PMID 8784344 DOI: 10.1038/Nsb0996-740  0.744
1996 Hingorani MM, Patel SS. Cooperative interactions of nucleotide ligands are linked to oligomerization and DNA binding in bacteriophage T7 gene 4 helicases. Biochemistry. 35: 2218-28. PMID 8652563 DOI: 10.1021/Bi9521497  0.734
1995 Egelman EH, Yu X, Wild R, Hingorani MM, Patel SS. Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases. Proceedings of the National Academy of Sciences of the United States of America. 92: 3869-73. PMID 7731998 DOI: 10.1073/Pnas.92.9.3869  0.753
1994 Kunkel TA, Patel SS, Johnson KA. Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit Proceedings of the National Academy of Sciences of the United States of America. 91: 6830-6834. PMID 8041704 DOI: 10.1073/Pnas.91.15.6830  0.619
1994 Patel SS, Hingorani MM, Ng WM. The K318A mutant of bacteriophage T7 DNA primase-helicase protein is deficient in helicase but not primase activity and inhibits primase-helicase protein wild-type activities by heterooligomer formation. Biochemistry. 33: 7857-68. PMID 8011649 DOI: 10.1021/Bi00191A013  0.704
1993 Hingorani MM, Patel SS. Interactions of bacteriophage T7 DNA primase/helicase protein with single- stranded and double-stranded DNAs Biochemistry. 32: 12478-12487. PMID 8241139 DOI: 10.1021/Bi00097A028  0.74
1991 Wong I, Patel SS, Johnson KA. An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics. Biochemistry. 30: 526-37. PMID 1846299 DOI: 10.1021/Bi00216A030  0.655
1991 Patel SS. Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant Biochemistry. 30: 511-525. DOI: 10.1021/Bi00216A029  0.469
1990 Ouyang T, Walt DR, Patel SS. Enzyme-catalyzed synthesis of citric acid using acetyl-coenzyme a recycling in a two-phase system Bioorganic Chemistry. 18: 131-135. DOI: 10.1016/0045-2068(90)90034-3  0.408
1988 Patel SS, Walt DR. Acetyl coenzyme A synthetase catalyzed reactions of coenzyme A with alpha, beta-unsaturated carboxylic acids. Analytical Biochemistry. 170: 355-60. PMID 2899406 DOI: 10.1016/0003-2697(88)90642-2  0.4
1987 Patel SS, Walt DR. Substrate specificity of acetyl coenzyme A synthetase. The Journal of Biological Chemistry. 262: 7132-4. PMID 2884217  0.418
1986 Patel SS, Conlon HD, Walt DR. Enzymic synthesis of L-acetylcarnitine and citric acid using acetyl coenzyme A recycling The Journal of Organic Chemistry. 51: 2842-2844. DOI: 10.1021/jo00364a052  0.397
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