| Year |
Citation |
Score |
| 2019 |
Boy KM, Guernon JM, Zuev DS, Xu L, Zhang Y, Shi J, Marcin LR, Higgins MA, Wu YJ, Krishnananthan S, Li J, Trehan A, Smith D, Toyn JH, Meredith JE, ... ... Albright CF, et al. Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481. Acs Medicinal Chemistry Letters. 10: 312-317. PMID 30891132 DOI: 10.1021/Acsmedchemlett.8B00541 |
0.346 |
|
| 2017 |
Robertson AS, Iben LG, Wei C, Meredith JE, Drexler DM, Banks M, Vite GD, Olson RE, Thompson LA, Albright CF, Ahlijanian MK, Toyn JH. Synergistic inhibition of Aβ production by combinations of γ-secretase modulators. European Journal of Pharmacology. PMID 28690193 DOI: 10.1016/J.Ejphar.2017.07.019 |
0.36 |
|
| 2017 |
Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Reports. 20: 76-88. PMID 28683325 DOI: 10.1016/J.Celrep.2017.06.023 |
0.313 |
|
| 2016 |
Wu YJ, Guernon J, Shi J, Marcin L, Higgins M, Rajamani R, Muckelbauer JK, Lewis HA, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, Macor JE, Thompson LA. Discovery of S3-truncated, C-6 heteroaryl substituted aminothiazine β-site APP cleaving enzyme-1 (BACE1) inhibitors. Journal of Medicinal Chemistry. PMID 27559936 DOI: 10.1021/Acs.Jmedchem.6B01012 |
0.348 |
|
| 2016 |
Wu YJ, Guernon J, Yang F, Snyder L, Shi J, Mcclure A, Rajamani R, Park H, Ng A, Lewis H, Chang C, Camac D, Toyn JH, Ahlijanian MK, Albright CF, et al. Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents. Acs Medicinal Chemistry Letters. 7: 271-6. PMID 26985314 DOI: 10.1021/Acsmedchemlett.5B00432 |
0.358 |
|
| 2015 |
Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, ... ... Albright CF, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614. PMID 25933020 DOI: 10.1371/Journal.Pone.0125614 |
0.33 |
|
| 2015 |
Thakker DR, Sankaranarayanan S, Weatherspoon MR, Harrison J, Pierdomenico M, Heisel JM, Thompson LA, Haskell R, Grace JE, Taylor SJ, Albright CF, Shafer LL. Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6931-6. PMID 25926467 DOI: 10.1523/Jneurosci.2262-14.2015 |
0.375 |
|
| 2014 |
Toyn JH, Thompson LA, Lentz KA, Meredith JE, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, ... ... Albright CF, et al. Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. International Journal of Alzheimer's Disease. 2014: 431858. PMID 25097793 DOI: 10.1155/2014/431858 |
0.337 |
|
| 2013 |
Meredith JE, Sankaranarayanan S, Guss V, Lanzetti AJ, Berisha F, Neely RJ, Slemmon JR, Portelius E, Zetterberg H, Blennow K, Soares H, Ahlijanian M, Albright CF. Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease. Plos One. 8: e76523. PMID 24116116 DOI: 10.1371/Journal.Pone.0076523 |
0.34 |
|
| 2013 |
Albright CF, Dockens RC, Meredith JE, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, et al. Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. The Journal of Pharmacology and Experimental Therapeutics. 344: 686-95. PMID 23275065 DOI: 10.1124/Jpet.112.199356 |
0.379 |
|
| 2012 |
Gerritz SW, Zhai W, Shi S, Zhu S, Toyn JH, Meredith JE, Iben LG, Burton CR, Albright CF, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Metzler W, Cook LS, et al. Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. Journal of Medicinal Chemistry. 55: 9208-23. PMID 23030502 DOI: 10.1021/Jm300931Y |
0.351 |
|
| 2012 |
Dockens R, Wang JS, Castaneda L, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Tong G. A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects. Clinical Pharmacokinetics. 51: 681-93. PMID 23018531 DOI: 10.1007/S40262-012-0005-X |
0.314 |
|
| 2012 |
Tong G, Castaneda L, Wang JS, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright C, Dockens RC. Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men. Clinical Drug Investigation. 32: 761-9. PMID 23018285 DOI: 10.1007/S40261-012-0006-4 |
0.346 |
|
| 2012 |
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, ... ... Albright CF, et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7137-45. PMID 22623658 DOI: 10.1523/Jneurosci.0188-12.2012 |
0.337 |
|
| 2012 |
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC. Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers. Clinical Therapeutics. 34: 654-67. PMID 22381714 DOI: 10.1016/J.Clinthera.2012.01.022 |
0.369 |
|
| 2012 |
Sankaranarayanan S, Meredith J, Guss V, Xu-Lin A, Soares H, Blennow K, Albright C, Ahlijanian M. Novel human CSF tau-fragment and pTau assays for distinguishing Alzheimer's from control subjects Alzheimers & Dementia. 8: 110. DOI: 10.1016/J.Jalz.2012.05.284 |
0.304 |
|
| 2011 |
Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, ... ... Albright CF, et al. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6909-15. PMID 21974952 DOI: 10.1016/J.Bmcl.2011.06.116 |
0.309 |
|
| 2011 |
Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, et al. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. 21: 6916-24. PMID 21782431 DOI: 10.1016/J.Bmcl.2011.06.109 |
0.302 |
|
| 2011 |
Barten DM, Cadelina GW, Hoque N, DeCarr LB, Guss VL, Yang L, Sankaranarayanan S, Wes PD, Flynn ME, Meredith JE, Ahlijanian MK, Albright CF. Tau transgenic mice as models for cerebrospinal fluid tau biomarkers. Journal of Alzheimer's Disease : Jad. 24: 127-41. PMID 21422517 DOI: 10.3233/Jad-2011-110161 |
0.318 |
|
| 2011 |
Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, ... ... Albright CF, et al. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Bioorganic & Medicinal Chemistry Letters. 21: 537-41. PMID 21078556 DOI: 10.1016/J.Bmcl.2010.10.079 |
0.348 |
|
| 2011 |
Albright C, Andreasen N, Minthon L, Blennow K, Feldman H, Soares H, Berisha F, Rhyne P, Rollin L, Coric V, Berman R. The gamma-secretase inhibitor BMS-708163 causes dose-dependent reductions in CSF Aβ40 levels in patients with mild-to-moderate Alzheimer's disease (AD) Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.905 |
0.349 |
|
| 2011 |
Feldman H, Coric V, Sperling R, Greenberg S, Bronen R, Sorensen AG, Salloway S, Pachai C, Kaplita S, Meadowcroft M, Albright C, Berman R. Cerebral microbleeds in a phase 2 clinical trial of mild-to-moderate Alzheimer's disease with the gamma secretase inhibitor BMS-708163 Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1080 |
0.3 |
|
| 2010 |
Gillman KW, Starrett JE, Parker MF, Xie K, Bronson JJ, Marcin LR, McElhone KE, Bergstrom CP, Mate RA, Williams R, Meredith JE, Burton CR, Barten DM, Toyn JH, Roberts SB, ... ... Albright CF, et al. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Acs Medicinal Chemistry Letters. 1: 120-4. PMID 24900185 DOI: 10.1021/Ml1000239 |
0.365 |
|
| 2010 |
Burton CR, Meredith JE, Toyn JH, Bradley JD, Wang Q, Sharp D, Sisk L, Guss V, Polson C, Krause CM, Wardwell-Swanson J, Guo Q, Fitzgerald K, Seiffert DE, Stern AM, ... ... Albright CF, et al. P3-288: Gamma-secretase inhibitors have intrinsically different potencies against Aβ production and Notch signaling Alzheimer's & Dementia. 6: S536-S536. DOI: 10.1016/J.Jalz.2010.05.1788 |
0.301 |
|
| 2009 |
Wu YJ, Zhang Y, Good AC, Burton CR, Toyn JH, Albright CF, Macor JE, Thompson LA. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE. Bioorganic & Medicinal Chemistry Letters. 19: 2654-60. PMID 19375914 DOI: 10.1016/J.Bmcl.2009.03.144 |
0.307 |
|
| 2008 |
Iben LG, Kopcho L, Marcinkeviciene J, Zheng C, Thompson LA, Albright CF, Toyn JH. [3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors. European Journal of Pharmacology. 593: 10-5. PMID 18655784 DOI: 10.1016/J.Ejphar.2008.06.112 |
0.344 |
|
| 2008 |
Barten DM, Albright CF. Therapeutic strategies for Alzheimer's disease. Molecular Neurobiology. 37: 171-86. PMID 18581273 DOI: 10.1007/S12035-008-8031-2 |
0.357 |
|
| 2008 |
Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, ... ... Albright CF, et al. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. The Journal of Biological Chemistry. 283: 22992-3003. PMID 18574238 DOI: 10.1074/Jbc.M804175200 |
0.341 |
|
| 2008 |
Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, ... ... Albright CF, et al. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. The Journal of Pharmacology and Experimental Therapeutics. 326: 502-13. PMID 18499745 DOI: 10.1124/Jpet.108.138974 |
0.38 |
|
| 2008 |
Olson RE, Albright CF. Recent progress in the medicinal chemistry of gamma-secretase inhibitors. Current Topics in Medicinal Chemistry. 8: 17-33. PMID 18220929 DOI: 10.2174/156802608783334088 |
0.382 |
|
| 2008 |
Meredith J, Thompson L, Toyn J, Marcin L, Barten D, Marcinkeviciene J, Burton C, Kopcho L, Kim Y, Lin A, Guss V, Iben L, Polson C, Cantone J, Ford M, ... ... Albright CF, et al. P2-346: PGP efflux and other factors limit brain Aβ reduction by BACE1 inhibitors in mice Alzheimer's & Dementia. 4: T474-T474. DOI: 10.1016/J.Jalz.2008.05.1423 |
0.302 |
|
| 2007 |
Iben LG, Olson RE, Balanda LA, Jayachandra S, Robertson BJ, Hay V, Corradi J, Prasad CV, Zaczek R, Albright CF, Toyn JH. Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. The Journal of Biological Chemistry. 282: 36829-36. PMID 17932033 DOI: 10.1074/Jbc.M707002200 |
0.362 |
|
| 2007 |
Goldstein ME, Cao Y, Fiedler T, Toyn J, Iben L, Barten DM, Pierdomenico M, Corsa J, Prasad CV, Olson RE, Li YW, Zaczek R, Albright CF. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. The Journal of Pharmacology and Experimental Therapeutics. 323: 102-8. PMID 17640949 DOI: 10.1124/Jpet.107.125492 |
0.353 |
|
| 2006 |
Barten DM, Meredith JE, Zaczek R, Houston JG, Albright CF. Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity. Drugs in R&D. 7: 87-97. PMID 16542055 DOI: 10.2165/00126839-200607020-00003 |
0.36 |
|
| 2000 |
Mach KE, Furge KA, Albright CF. Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation. Genetics. 155: 611-22. PMID 10835385 |
0.568 |
|
| 2000 |
Li C, Furge KA, Cheng QC, Albright CF. Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast. The Journal of Biological Chemistry. 275: 14381-7. PMID 10799520 DOI: 10.1074/Jbc.275.19.14381 |
0.608 |
|
| 1999 |
Furge KA, Cheng QC, Jwa M, Shin S, Song K, Albright CF. Regions of Byr4, a regulator of septation in fission yeast, that bind Spg1 or Cdc16 and form a two-component GTPase-activating protein with Cdc16. The Journal of Biological Chemistry. 274: 11339-43. PMID 10196225 DOI: 10.1074/Jbc.274.16.11339 |
0.607 |
|
| 1998 |
Bauman P, Albright CF. Functional analysis of domains in the Byr2 kinase Biochimie. 80: 621-625. PMID 9810469 DOI: 10.1016/S0300-9084(98)80015-1 |
0.309 |
|
| 1998 |
Furge KA, Wong K, Armstrong J, Balasubramanian M, Albright CF. Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Current Biology : Cb. 8: 947-54. PMID 9742395 DOI: 10.1016/S0960-9822(98)70394-X |
0.599 |
|
| 1998 |
Bauman P, Cheng QC, Albright CF. The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner Biochemical and Biophysical Research Communications. 244: 468-474. PMID 9514947 DOI: 10.1006/Bbrc.1998.8292 |
0.326 |
|
| 1996 |
Song K, Mach KE, Chen CY, Reynolds T, Albright CF. A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis Journal of Cell Biology. 133: 1307-1319. PMID 8682866 DOI: 10.1083/Jcb.133.6.1307 |
0.326 |
|
| 1992 |
Settleman J, Albright CF, Foster LC, Weinberg RA. Association between GTPase activators for Rho and Ras families Nature. 359: 153-154. PMID 1522900 DOI: 10.1038/359153A0 |
0.414 |
|
| 1990 |
Albright CF, Robbins PW. The sequence and transcript heterogeneity of the yeast gene ALG1, an essential mannosyltransferase involved in N-glycosylation Journal of Biological Chemistry. 265: 7042-7049. PMID 2182636 |
0.481 |
|
| 1989 |
Albright CF, Orlean P, Robbins PW. A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition. Proceedings of the National Academy of Sciences of the United States of America. 86: 7366-9. PMID 2678101 DOI: 10.1073/Pnas.86.19.7366 |
0.471 |
|
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