| Year |
Citation |
Score |
| 2014 |
Chen H, Beardsley GP, Coen DM. Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proceedings of the National Academy of Sciences of the United States of America. 111: 17462-7. PMID 25422422 DOI: 10.1073/Pnas.1405981111 |
0.354 |
|
| 2007 |
Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/Jbc.M607293200 |
0.455 |
|
| 2004 |
Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. The Journal of Biological Chemistry. 279: 18034-45. PMID 14966129 DOI: 10.1074/Jbc.M313691200 |
0.56 |
|
| 2004 |
Vergis JM, Beardsley GP. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. Biochemistry. 43: 1184-92. PMID 14756554 DOI: 10.1021/Bi035139B |
0.754 |
|
| 2002 |
Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Structural insights into the avian AICAR transformylase mechanism. Biochemistry. 41: 15505-13. PMID 12501179 DOI: 10.1021/Bi020505X |
0.497 |
|
| 2002 |
Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. Biochemistry. 41: 14206-15. PMID 12450384 DOI: 10.1021/Bi020522M |
0.426 |
|
| 2002 |
Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 10: 2739-49. PMID 12057663 DOI: 10.1016/S0968-0896(02)00102-5 |
0.456 |
|
| 2002 |
Bulock KG, Beardsley GP, Anderson KS. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. The Journal of Biological Chemistry. 277: 22168-74. PMID 11948179 DOI: 10.1074/Jbc.M111964200 |
0.744 |
|
| 2001 |
Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nature Structural Biology. 8: 402-6. PMID 11323713 DOI: 10.1038/87555 |
0.386 |
|
| 2001 |
Vergis JM, Bulock KG, Fleming KG, Beardsley GP. Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity. The Journal of Biological Chemistry. 276: 7727-33. PMID 11096114 DOI: 10.1074/Jbc.M009940200 |
0.644 |
|
| 2000 |
Cinquina CC, Grogan E, Sun R, Lin SF, Beardsley GP, Miller G. Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. Virology. 268: 201-17. PMID 10683342 DOI: 10.1006/Viro.1999.0165 |
0.671 |
|
| 1998 |
Beardsley GP, Rayl EA, Gunn K, Moroson BA, Seow H, Anderson KS, Vergis J, Fleming K, Worland S, Condon B, Davies J. Structure and functional relationships in human pur H. Advances in Experimental Medicine and Biology. 431: 221-6. PMID 9598063 DOI: 10.1007/978-1-4615-5381-6_43 |
0.731 |
|
| 1997 |
Rayl EA, Moroson BA, Beardsley G, Anderson KS. Pre-steady state kinetic analysis of the bifunctional human amino-imidazole carboxamide ribonucleotide formyltransferase/AMP cyclohydrolase (AICARFT/IMPCHase), a 10-formyltetrahydro-folate-requiring enzyme essential for de novo purine biosynthesis Clinical Biochemistry. 30: 275-276. DOI: 10.1016/S0009-9120(97)87769-7 |
0.519 |
|
| 1997 |
Gunn K, Beardsley G. Identification of the substrate binding and catalytic sites of the 5-aminoimidazole-carboxamide ribonucleotide formyltransferase activity in human PurH Clinical Biochemistry. 30: 258. DOI: 10.1016/S0009-9120(97)87698-9 |
0.454 |
|
| 1996 |
Rayl EA, Moroson BA, Beardsley GP. The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. The Journal of Biological Chemistry. 271: 2225-33. PMID 8567683 DOI: 10.1074/jbc.271.4.2225 |
0.386 |
|
| 1987 |
Clark JM, Joyce CM, Beardsley GP. Novel blunt-end addition reactions catalyzed by DNA polymerase I of Escherichia coli. Journal of Molecular Biology. 198: 123-7. PMID 3323527 DOI: 10.1016/0022-2836(87)90462-1 |
0.426 |
|
| 1980 |
Crane LE, Beardsley GP, Maki Y. Synthesis of pyrrolo[3,2-d]pyrimidines from furazano[3,4-d]pyrimidines via enolate and ene adducts Journal of Organic Chemistry. 45: 3827-3831. DOI: 10.1021/Jo01307A019 |
0.323 |
|
| 1979 |
Abelson HT, Gorka C, Beardsley GP. Identification of dihydropteridine reductase in human platelets. Blood. 53: 116-21. PMID 758207 |
0.378 |
|
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