Dennis J. Thiele - Publications

University of Michigan, Ann Arbor, Ann Arbor, MI 
Molecular Biology, Biochemistry

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Öhrvik H, Logeman B, Noguchi G, Eriksson I, Kjellén L, Thiele DJ, Pejler G. Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans. Journal of Immunology (Baltimore, Md. : 1950). 195: 3654-64. PMID 26342034 DOI: 10.4049/jimmunol.1500283  0.44
2015 Shawki A, Anthony SR, Nose Y, Engevik MA, Niespodzany EJ, Barrientos T, Öhrvik H, Worrell RT, Thiele DJ, Mackenzie B. Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G635-47. PMID 26294671 DOI: 10.1152/ajpgi.00160.2015  0.44
2015 García-Santamarina S, Thiele DJ. Copper at the Fungal Pathogen-Host Axis. The Journal of Biological Chemistry. 290: 18945-53. PMID 26055724 DOI: 10.1074/jbc.R115.649129  0.44
2015 Crumbliss AL, Franz KJ, Thiele DJ. Preface. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 28: 431. PMID 25929460 DOI: 10.1007/s10534-015-9854-8  0.44
2015 Allensworth JL, Evans MK, Bertucci F, Aldrich AJ, Festa RA, Finetti P, Ueno NT, Safi R, McDonnell DP, Thiele DJ, Van Laere S, Devi GR. Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. Molecular Oncology. 9: 1155-68. PMID 25769405 DOI: 10.1016/j.molonc.2015.02.007  0.44
2015 Öhrvik H, Thiele DJ. The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 31: 178-82. PMID 24703712 DOI: 10.1016/j.jtemb.2014.03.006  0.44
2014 Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, et al. Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. Chemistry & Biology. 21: 1648-59. PMID 25500222 DOI: 10.1016/j.chembiol.2014.10.016  0.44
2014 Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Reports. 9: 955-66. PMID 25437552 DOI: 10.1016/j.celrep.2014.09.056  0.44
2014 Sun TS, Ju X, Gao HL, Wang T, Thiele DJ, Li JY, Wang ZY, Ding C. Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. Nature Communications. 5: 5550. PMID 25417972 DOI: 10.1038/ncomms6550  0.44
2014 Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. The Journal of Biological Chemistry. 289: 30459-69. PMID 25204655 DOI: 10.1074/jbc.M114.591578  0.44
2014 Festa RA, Helsel ME, Franz KJ, Thiele DJ. Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection. Chemistry & Biology. 21: 977-87. PMID 25088681 DOI: 10.1016/j.chembiol.2014.06.009  0.44
2014 Graper ML, Huster D, Kaler SG, Lutsenko S, Schilsky ML, Thiele DJ. Introduction to Human Disorders of Copper Metabolism. Annals of the New York Academy of Sciences. 1314: v-vi. PMID 24820197 DOI: 10.1111/nyas.12448  0.44
2014 Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 509: 492-6. PMID 24717435 DOI: 10.1038/nature13180  0.44
2014 Ohrvik H, Thiele DJ. How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1. Annals of the New York Academy of Sciences. 1314: 32-41. PMID 24697869 DOI: 10.1111/nyas.12371  0.44
2014 Palacios Ò, Espart A, Espín J, Ding C, Thiele DJ, Atrian S, Capdevila M. Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors. Metallomics : Integrated Biometal Science. 6: 279-91. PMID 24317230 DOI: 10.1039/c3mt00266g  0.44
2013 Öhrvik H, Nose Y, Wood LK, Kim BE, Gleber SC, Ralle M, Thiele DJ. Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Proceedings of the National Academy of Sciences of the United States of America. 110: E4279-88. PMID 24167251 DOI: 10.1073/pnas.1311749110  0.44
2013 Neef DW, Jaeger AM, Thiele DJ. Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding. G3 (Bethesda, Md.). 3: 1315-24. PMID 23733891 DOI: 10.1534/g3.113.006692  0.44
2013 Martínez-Pastor M, Vergara SV, Puig S, Thiele DJ. Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation. Molecular and Cellular Biology. 33: 2178-87. PMID 23530061 DOI: 10.1128/MCB.01458-12  0.44
2013 Ding C, Festa RA, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ. Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host & Microbe. 13: 265-76. PMID 23498952 DOI: 10.1016/j.chom.2013.02.002  0.44
2013 Batista-Nascimento L, Toledano MB, Thiele DJ, Rodrigues-Pousada C. Yeast protective response to arsenate involves the repression of the high affinity iron uptake system. Biochimica Et Biophysica Acta. 1833: 997-1005. PMID 23295455 DOI: 10.1016/j.bbamcr.2012.12.018  0.44
2012 Festa RA, Thiele DJ. Copper at the front line of the host-pathogen battle. Plos Pathogens. 8: e1002887. PMID 23028306 DOI: 10.1371/journal.ppat.1002887  0.44
2012 Nevitt T, Ohrvik H, Thiele DJ. Charting the travels of copper in eukaryotes from yeast to mammals. Biochimica Et Biophysica Acta. 1823: 1580-93. PMID 22387373 DOI: 10.1016/j.bbamcr.2012.02.011  0.44
2012 Samanovic MI, Ding C, Thiele DJ, Darwin KH. Copper in microbial pathogenesis: meddling with the metal. Cell Host & Microbe. 11: 106-15. PMID 22341460 DOI: 10.1016/j.chom.2012.01.009  0.44
2012 Turski ML, Brady DC, Kim HJ, Kim BE, Nose Y, Counter CM, Winge DR, Thiele DJ. A novel role for copper in Ras/mitogen-activated protein kinase signaling. Molecular and Cellular Biology. 32: 1284-95. PMID 22290441 DOI: 10.1128/MCB.05722-11  0.44
2011 Neef DW, Jaeger AM, Thiele DJ. Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nature Reviews. Drug Discovery. 10: 930-44. PMID 22129991 DOI: 10.1038/nrd3453  0.44
2011 Festa RA, Thiele DJ. Copper: an essential metal in biology. Current Biology : Cb. 21: R877-83. PMID 22075424 DOI: 10.1016/j.cub.2011.09.040  0.44
2011 Ding C, Yin J, Tovar EM, Fitzpatrick DA, Higgins DG, Thiele DJ. The copper regulon of the human fungal pathogen Cryptococcus neoformans H99. Molecular Microbiology. 81: 1560-76. PMID 21819456 DOI: 10.1111/j.1365-2958.2011.07794.x  0.44
2011 Nevitt T, Thiele DJ. Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing. Plos Pathogens. 7: e1001322. PMID 21445236 DOI: 10.1371/journal.ppat.1001322  0.44
2011 Haas KL, Putterman AB, White DR, Thiele DJ, Franz KJ. Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. Journal of the American Chemical Society. 133: 4427-37. PMID 21375246 DOI: 10.1021/ja108890c  0.44
2011 Beaudoin J, Thiele DJ, Labbé S, Puig S. Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions. Microbiology (Reading, England). 157: 1021-31. PMID 21273250 DOI: 10.1099/mic.0.046854-0  0.44
2011 Batista-Nascimento L, Neef DW, Liu PC, Rodrigues-Pousada C, Thiele DJ. Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. Plos One. 6: e15976. PMID 21253609 DOI: 10.1371/journal.pone.0015976  0.44
2011 Vergara SV, Puig S, Thiele DJ. Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency. Molecular and Cellular Biology. 31: 417-29. PMID 21135132 DOI: 10.1128/MCB.00754-10  0.44
2010 Nose Y, Wood LK, Kim BE, Prohaska JR, Fry RS, Spears JW, Thiele DJ. Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. The Journal of Biological Chemistry. 285: 32385-92. PMID 20699218 DOI: 10.1074/jbc.M110.143826  0.44
2010 Kim BE, Turski ML, Nose Y, Casad M, Rockman HA, Thiele DJ. Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. Cell Metabolism. 11: 353-63. PMID 20444417 DOI: 10.1016/j.cmet.2010.04.003  0.44
2010 Steiger D, Fetchko M, Vardanyan A, Atanesyan L, Steiner K, Turski ML, Thiele DJ, Georgiev O, Schaffner W. The Drosophila copper transporter Ctr1C functions in male fertility. The Journal of Biological Chemistry. 285: 17089-97. PMID 20351114 DOI: 10.1074/jbc.M109.090282  0.44
2010 Neef DW, Turski ML, Thiele DJ. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. Plos Biology. 8: e1000291. PMID 20098725 DOI: 10.1371/journal.pbio.1000291  0.44
2009 Neef DW, Thiele DJ. Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Molecular Microbiology. 73: 1032-42. PMID 19682251 DOI: 10.1111/j.1365-2958.2009.06827.x  0.44
2009 Vergara SV, Thiele DJ. Ironing out a midlife crisis. Cell. 137: 1179-81. PMID 19563748 DOI: 10.1016/j.cell.2009.06.005  0.44
2009 Wood LK, Thiele DJ. Transcriptional activation in yeast in response to copper deficiency involves copper-zinc superoxide dismutase. The Journal of Biological Chemistry. 284: 404-13. PMID 18977757 DOI: 10.1074/jbc.M807027200  0.44
2009 Turski ML, Thiele DJ. New roles for copper metabolism in cell proliferation, signaling, and disease. The Journal of Biological Chemistry. 284: 717-21. PMID 18757361 DOI: 10.1074/jbc.R800055200  0.44
2009 Turski ML, Thiele DJ. New roles for copper meabolism in cell proliferation,signaling, and disease Journal of Biological Chemistry. 284: 723-727. DOI: 10.1074/jbc.R800045200  0.44
2009 Schilsky ML, Thiele DJ. Copper Metabolism and the Liver The Liver: Biology and Pathobiology: Fifth Edition. 221-233. DOI: 10.1002/9780470747919.ch15  0.44
2008 Vergara SV, Thiele DJ. Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins. Biochemical Society Transactions. 36: 1088-90. PMID 18793194 DOI: 10.1042/BST0361088  0.44
2008 Pedro-Segura E, Vergara SV, Rodríguez-Navarro S, Parker R, Thiele DJ, Puig S. The Cth2 ARE-binding protein recruits the Dhh1 helicase to promote the decay of succinate dehydrogenase SDH4 mRNA in response to iron deficiency. The Journal of Biological Chemistry. 283: 28527-35. PMID 18715869 DOI: 10.1074/jbc.M804910200  0.44
2008 Puig S, Vergara SV, Thiele DJ. Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency. Cell Metabolism. 7: 555-64. PMID 18522836 DOI: 10.1016/j.cmet.2008.04.010  0.44
2008 Kim BE, Nevitt T, Thiele DJ. Mechanisms for copper acquisition, distribution and regulation. Nature Chemical Biology. 4: 176-85. PMID 18277979 DOI: 10.1038/nchembio.72  0.44
2008 Thiele DJ, Gitlin JD. Assembling the pieces. Nature Chemical Biology. 4: 145-7. PMID 18277968 DOI: 10.1038/nchembio0308-145  0.44
2007 Turski ML, Thiele DJ. Drosophila Ctr1A functions as a copper transporter essential for development. The Journal of Biological Chemistry. 282: 24017-26. PMID 17573340 DOI: 10.1074/jbc.M703792200  0.44
2007 Rees EM, Thiele DJ. Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. The Journal of Biological Chemistry. 282: 21629-38. PMID 17553781 DOI: 10.1074/jbc.M703397200  0.44
2007 Puig S, Mira H, Dorcey E, Sancenón V, Andrés-Colás N, Garcia-Molina A, Burkhead JL, Gogolin KA, Abdel-Ghany SE, Thiele DJ, Ecker JR, Pilon M, Peñarrubia L. Higher plants possess two different types of ATX1-like copper chaperones Biochemical and Biophysical Research Communications. 354: 385-390. PMID 17223078 DOI: 10.1016/j.bbrc.2006.12.215  0.44
2006 Nose Y, Rees EM, Thiele DJ. Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture. Trends in Biochemical Sciences. 31: 604-7. PMID 16982196 DOI: 10.1016/j.tibs.2006.09.003  0.44
2006 Nose Y, Kim BE, Thiele DJ. Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metabolism. 4: 235-44. PMID 16950140 DOI: 10.1016/j.cmet.2006.08.009  0.44
2006 Hahn JS, Neef DW, Thiele DJ. A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor Molecular Microbiology. 60: 240-251. PMID 16556235 DOI: 10.1111/j.1365-2958.2006.05097.x  0.44
2006 Park KW, Hahn JS, Fan Q, Thiele DJ, Li L. De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor Genetics. 173: 35-47. PMID 16452152 DOI: 10.1534/genetics.105.054221  0.44
2006 Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L. Inhibition of DNA binding by differential sumoylation of heat shock factors. Molecular and Cellular Biology. 26: 955-64. PMID 16428449 DOI: 10.1128/MCB.26.3.955-964.2006  0.44
2006 Andrés-Colás N, Sancenón V, Rodríguez-Navarro S, Mayo S, Thiele DJ, Ecker JR, Puig S, Peñarrubia L. The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots Plant Journal. 45: 225-236. PMID 16367966 DOI: 10.1111/j.1365-313X.2005.02601.x  0.44
2005 Selvaraj A, Balamurugan K, Yepiskoposyan H, Zhou H, Egli D, Georgiev O, Thiele DJ, Schaffner W. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes & Development. 19: 891-6. PMID 15833915 DOI: 10.1101/gad.1301805  0.44
2005 Puig S, Askeland E, Thiele DJ. Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell. 120: 99-110. PMID 15652485 DOI: 10.1016/j.cell.2004.11.032  0.44
2004 Rees EM, Lee J, Thiele DJ. Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. The Journal of Biological Chemistry. 279: 54221-9. PMID 15494390 DOI: 10.1074/jbc.M411669200  0.44
2004 Hahn JS, Hu Z, Thiele DJ, Iyer VR. Genome-wide analysis of the biology of stress responses through heat shock transcription factor. Molecular and Cellular Biology. 24: 5249-56. PMID 15169889 DOI: 10.1128/MCB.24.12.5249-5256.2004  0.44
2004 Puig S, Lau M, Thiele DJ. Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 279: 30298-306. PMID 15133041 DOI: 10.1074/jbc.M313463200  0.44
2004 Rees EM, Thiele DJ. From aging to virulence: forging connections through the study of copper homeostasis in eukaryotic microorganisms. Current Opinion in Microbiology. 7: 175-84. PMID 15063856 DOI: 10.1016/j.mib.2004.02.004  0.44
2004 Guo Y, Smith K, Lee J, Thiele DJ, Petris MJ. Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter. The Journal of Biological Chemistry. 279: 17428-33. PMID 14976198 DOI: 10.1074/jbc.M401493200  0.44
2004 Sancenón V, Puig S, Mateu-Andrés I, Dorcey E, Thiele DJ, Peñarrubia L. The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. The Journal of Biological Chemistry. 279: 15348-55. PMID 14726516 DOI: 10.1074/jbc.M313321200  0.44
2004 Hahn JS, Thiele DJ. Activation of the Saccharomyces cerevisiae Heat Shock Transcription Factor under Glucose Starvation Conditions by Snf1 Protein Kinase Journal of Biological Chemistry. 279: 5169-5176. PMID 14612437 DOI: 10.1074/jbc.M311005200  0.44
2004 Riggio M, Scudiero R, Lee J, Thiele DJ, Parisi E, Filosa S. Metal accumulation and transport in the ovary of the lizard Podarcis sicula Italian Journal of Zoology. 71: 59-62. DOI: 10.1080/11250000409356607  0.44
2003 Zhou H, Cadigan KM, Thiele DJ. A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. The Journal of Biological Chemistry. 278: 48210-8. PMID 12966081 DOI: 10.1074/jbc.M309820200  0.44
2003 Thiele DJ. Integrating trace element metabolism from the cell to the whole organism. The Journal of Nutrition. 133: 1579S-80S. PMID 12730470  0.44
2003 Sancenón V, Puig S, Mira H, Thiele DJ, Peñarrubia L. Identification of a copper transporter family in Arabidopsis thaliana. Plant Molecular Biology. 51: 577-87. PMID 12650623 DOI: 10.1023/A:1022345507112  0.44
2003 Ahn SG, Thiele DJ. Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. Genes & Development. 17: 516-28. PMID 12600944 DOI: 10.1101/gad.1044503  0.44
2003 Petris MJ, Smith K, Lee J, Thiele DJ. Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. The Journal of Biological Chemistry. 278: 9639-46. PMID 12501239 DOI: 10.1074/jbc.M209455200  0.44
2002 Puig S, Rees EM, Thiele DJ. The ABCDs of periplasmic copper trafficking. Structure (London, England : 1993). 10: 1292-5. PMID 12377116 DOI: 10.1016/S0969-2126(02)00863-8  0.44
2002 Ishida S, Lee J, Thiele DJ, Herskowitz I. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proceedings of the National Academy of Sciences of the United States of America. 99: 14298-302. PMID 12370430 DOI: 10.1073/pnas.162491399  0.44
2002 Lee J, Petris MJ, Thiele DJ. Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. The Journal of Biological Chemistry. 277: 40253-9. PMID 12177073 DOI: 10.1074/jbc.M208002200  0.44
2002 Puig S, Thiele DJ. Molecular mechanisms of copper uptake and distribution. Current Opinion in Chemical Biology. 6: 171-80. PMID 12039001 DOI: 10.1016/S1367-5931(02)00298-3  0.44
2002 Riggio M, Lee J, Scudiero R, Parisi E, Thiele DJ, Filosa S. High affinity copper transport protein in the lizard Podarcis sicula: molecular cloning, functional characterization and expression in somatic tissues, follicular oocytes and eggs. Biochimica Et Biophysica Acta. 1576: 127-35. PMID 12031492 DOI: 10.1016/S0167-4781(02)00337-8  0.44
2002 Puig S, Lee J, Lau M, Thiele DJ. Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake. The Journal of Biological Chemistry. 277: 26021-30. PMID 11983704 DOI: 10.1074/jbc.M202547200  0.44
2002 Hahn JS, Thiele DJ. Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase Journal of Biological Chemistry. 277: 21278-21284. PMID 11923319 DOI: 10.1074/jbc.M202557200  0.44
2002 Lee J, Peña MM, Nose Y, Thiele DJ. Biochemical characterization of the human copper transporter Ctr1. The Journal of Biological Chemistry. 277: 4380-7. PMID 11734551 DOI: 10.1074/jbc.M104728200  0.44
2001 Liu PCC, Thiele DJ. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40s ribosome biogenesis Molecular Biology of the Cell. 12: 3644-3657. PMID 11694595  0.44
2001 Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes & Development. 15: 2134-45. PMID 11511544 DOI: 10.1101/gad.894801  0.44
2001 Koch KA, Allard S, Santoro N, Côté J, Thiele DJ. The Candida glabrata Amt1 copper-sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification. Molecular Microbiology. 40: 1165-74. PMID 11401720 DOI: 10.1046/j.1365-2958.2001.02458.x  0.44
2001 Lee J, Prohaska JR, Thiele DJ. Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development Proceedings of the National Academy of Sciences of the United States of America. 98: 6842-6847. PMID 11391005 DOI: 10.1073/pnas.111058698  0.44
2001 Zhou H, Thiele DJ. Identification of a Novel High Affinity Copper Transport Complex in the Fission Yeast Schizosaccharomyces pombe Journal of Biological Chemistry. 276: 20529-20535. PMID 11274192 DOI: 10.1074/jbc.M102004200  0.44
2000 Lee J, Prohaska JR, Dagenais SL, Glover TW, Thiele DJ. Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant Gene. 254: 87-96. PMID 10974539 DOI: 10.1016/S0378-1119(00)00287-0  0.44
2000 Pena MM, Puig S, Thiele DJ. Characterization of the Saccharomyces cerevisiae high affinity copper transporter Ctr3. The Journal of Biological Chemistry. 275: 33244-51. PMID 10924521 DOI: 10.1074/jbc.M005392200  0.44
2000 Chiang KT, Shinyashiki M, Switzer CH, Valentine JS, Gralla EB, Thiele DJ, Fukuto JM. Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide. Archives of Biochemistry and Biophysics. 377: 296-303. PMID 10845707 DOI: 10.1006/abbi.2000.1785  0.44
2000 Shinyashiki M, Chiang KT, Switzer CH, Gralla EB, Valentine JS, Thiele DJ, Fukuto JM. The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism. Proceedings of the National Academy of Sciences of the United States of America. 97: 2491-6. PMID 10694579 DOI: 10.1073/pnas.050586597  0.44
1999 Labbé S, Thiele DJ. Pipes and wiring: The regulation of copper uptake and distribution in yeast Trends in Microbiology. 7: 500-505. PMID 10603486 DOI: 10.1016/S0966-842X(99)01638-8  0.44
1999 Labbé S, Peña MM, Fernandes AR, Thiele DJ. A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 274: 36252-60. PMID 10593913 DOI: 10.1074/jbc.274.51.36252  0.44
1999 Morano KA, Thiele DJ. The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo Embo Journal. 18: 5953-5962. PMID 10545107 DOI: 10.1093/emboj/18.21.5953  0.44
1999 Tanabe M, Sasai N, Nagata K, Liu XD, Liu PCC, Thiele DJ, Nakai A. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing Journal of Biological Chemistry. 274: 27845-27856. PMID 10488131 DOI: 10.1074/jbc.274.39.27845  0.44
1999 Liu XD, Morano KA, Thiele DJ. The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone Journal of Biological Chemistry. 274: 26654-26660. PMID 10480867 DOI: 10.1074/jbc.274.38.26654  0.44
1999 Koch KA, Thiele DJ. Functional analysis of a homopolymeric (dA-dT) element that provides nucleosomal access to yeast and mammalian transcription factors Journal of Biological Chemistry. 274: 23752-23760. PMID 10446135 DOI: 10.1074/jbc.274.34.23752  0.44
1999 Morano KA, Thiele DJ. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals Gene Expression. 7: 271-282. PMID 10440228  0.44
1999 Labbé S, Thiele DJ. Copper ion inducible and repressible promoter systems in yeast Methods in Enzymology. 306: 145-153. PMID 10432452 DOI: 10.1016/S0076-6879(99)06010-3  0.44
1999 Peña MM, Lee J, Thiele DJ. A delicate balance: homeostatic control of copper uptake and distribution. The Journal of Nutrition. 129: 1251-60. PMID 10395584  0.44
1999 Liu PCC, Thiele DJ. Modulation of human heat shock factor trimerization by the linker domain Journal of Biological Chemistry. 274: 17219-17225. PMID 10358080 DOI: 10.1074/jbc.274.24.17219  0.44
1999 Morano KA, Santoro N, Koch KA, Thiele DJ. A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress. Molecular and Cellular Biology. 19: 402-11. PMID 9858564  0.44
1998 Morano KA, Liu PCC, Thiele DJ. Protein chaperones and the heat shock response in Saccharomyces cerevisiae Current Opinion in Microbiology. 1: 197-203. PMID 10066474  0.44
1998 Santoro N, Johansson N, Thiele DJ. Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor. Molecular and Cellular Biology. 18: 6340-52. PMID 9774650  0.44
1998 Peña MMO, Koch KA, Thiele DJ. Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae Molecular and Cellular Biology. 18: 2514-2523. PMID 9599102  0.44
1998 Zhu Z, Labbé S, Peña MM, Thiele DJ. Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor. The Journal of Biological Chemistry. 273: 1277-80. PMID 9430656 DOI: 10.1074/jbc.273.3.1277  0.44
1997 Szczypka MS, Zhu Z, Silar P, Thiele DJ. Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription Yeast. 13: 1423-1435. PMID 9434348 DOI: 10.1002/(SICI)1097-0061(199712)13:15<1423::AID-YEA190>3.0.CO;2-C  0.44
1997 Liu XD, Liu PC, Santoro N, Thiele DJ. Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. The Embo Journal. 16: 6466-77. PMID 9351828 DOI: 10.1093/emboj/16.21.6466  0.44
1997 Koch KA, Peña MMO, Thiele DJ. Copper-binding motifs in catalysis, transport, detoxification and signaling Chemistry and Biology. 4: 549-560. PMID 9281528  0.44
1997 Labbé S, Zhu Z, Thiele DJ. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway Journal of Biological Chemistry. 272: 15951-15958. PMID 9188496 DOI: 10.1074/jbc.272.25.15951  0.44
1997 Liu XD, Thiele DJ. Yeast metallothionein gene expression in response to metals and oxidative stress Methods: a Companion to Methods in Enzymology. 11: 289-299. PMID 9073572 DOI: 10.1006/meth.1996.0423  0.44
1997 Li ZS, Lu YP, Zhen RG, Szczypka M, Thiele DJ, Rea PA. A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium Proceedings of the National Academy of Sciences of the United States of America. 94: 42-47. PMID 8990158 DOI: 10.1073/pnas.94.1.42  0.44
1996 Zhu Z, Thiele DJ. A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter Cell. 87: 459-470. PMID 8898199 DOI: 10.1016/S0092-8674(00)81366-5  0.44
1996 Zhu Z, Thiele DJ. Toxic metal-responsive gene transcription Exs. 77: 307-320. PMID 8856982  0.44
1996 Knight SAB, Labbé S, Kwon LF, Kosman DJ, Thiele DJ. A widespread transposable element masks expression of a yeast copper transport gene Genes and Development. 10: 1917-1929. PMID 8756349  0.44
1996 Li ZS, Szczypka M, Lu YP, Thiele DJ, Rea PA. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump Journal of Biological Chemistry. 271: 6509-6517. PMID 8626454  0.44
1996 Liu XD, Thiele DJ. Oxidative stress induces heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription Genes and Development. 10: 592-603. PMID 8598289  0.44
1996 Koch KA, Thiele DJ. Autoactivation by a Candida glabrata copper metalloregulatory transcription factor requires critical minor groove interactions Molecular and Cellular Biology. 16: 724-734. PMID 8552101  0.44
1996 Catallo WJ, Henk W, Younger L, Mills O, Thiele DJ, Meyers SP. Trace metal uptake by Pichia spartinae, an endosymbiotic yeast in the salt marsh cord grass Spartina alterniflora Chemistry and Ecology. 13: 113-131.  0.44
1994 Zhou P, Szczypka MS, Young R, Thiele DJ. A system for gene cloning and manipulation in the yeast Candida glabrata Gene. 142: 135-140. PMID 8181748 DOI: 10.1016/0378-1119(94)90368-9  0.44
1994 Tamai KT, Liu X, Silar P, Sosinowski T, Thiele DJ. Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways. Molecular and Cellular Biology. 14: 8155-65. PMID 7969152  0.44
1994 Knight SAB, Tamai KT, Kosman DJ, Thiele DJ. Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein Molecular and Cellular Biology. 14: 7792-7804. PMID 7969120  0.44
1994 Wemmie JA, Szczypka MS, Thiele DJ, Moye-Rowley WS. Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1 Journal of Biological Chemistry. 269: 32592-32597. PMID 7798263  0.44
1994 Szczypka MS, Wemmie JA, Moye-Rowley WS, Thiele DJ. A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein Journal of Biological Chemistry. 269: 22853-22857. PMID 7521334  0.44
1993 Stott K, Saito K, Thiele DJ, Massey V. Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins. The Journal of Biological Chemistry. 268: 6097-106. PMID 8454584  0.44
1993 Zhou P, Thiele DJ. Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for nigh-level copper detoxification Genes and Development. 7: 1824-1835. PMID 8370529  0.44
1993 Tamai KT, Gralla EB, Ellerby LM, Valentine JS, Thiele DJ. Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 90: 8013-7. PMID 8367458  0.44
1993 Zhou P, Thiele DJ. Copper and gene regulation in yeast Biofactors. 4: 105-115. PMID 8347274  0.44
1992 Dohrmann PR, Butler G, Tamai K, Dorland S, Greene JR, Thiele DJ, Stillman DJ. Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes & Development. 6: 93-104. PMID 1730413  0.44
1992 Thiele DJ. Metal-regulated transcription in eukaryotes Nucleic Acids Research. 20: 1183-1191. PMID 1561077 DOI: 10.1093/nar/20.6.1183  0.44
1992 Zhou P, Szczypka MS, Sosinowski T, Thiele DJ. Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor. Molecular and Cellular Biology. 12: 3766-75. PMID 1508182  0.44
1991 Zhou P, Thiele DJ. Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 88: 6112-6116. PMID 2068090  0.44
1991 Silar P, Butler G, Thiele DJ. Heat shock transcription factor activates transcription of the yeast metallothionein gene Molecular and Cellular Biology. 11: 1232-1238. PMID 1996089  0.44
1991 Butler G, Thiele DJ. ACE2, an Activator of Yeast Metallothionein Expression Which Is Homologous to SWI5 Molecular and Cellular Biology. 11: 476-485. PMID 1986241  0.44
1991 Saito K, Thiele DJ, Davio M, Lockridge O, Massey V. The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis. The Journal of Biological Chemistry. 266: 20720-4. PMID 1939123  0.44
1991 Gralla EB, Thiele DJ, Silar P, Valentine JS. ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene. Proceedings of the National Academy of Sciences of the United States of America. 88: 8558-62. PMID 1924315  0.44
1991 Silar P, Thiele DJ. New shuttle vectors for direct cloning in Saccharomyces cerevisiae Gene. 104: 99-102. PMID 1916284 DOI: 10.1016/0378-1119(91)90472-N  0.44
1990 Evans CF, Engelke DR, Thiele DJ. ACE1 transcription factor produced in Escherichia coli binds multiple regions within yeast metallothionein upstream activation sequences Molecular and Cellular Biology. 10: 426-429. PMID 2403647  0.44
1990 Fujita VS, Thiele DJ, Coon MJ. Expression of alcohol-inducible rabbit liver cytochrome P-450 3a (P-450IIE1) in Saccharomyces cerevisiae with the copper-inducible CUP1 promoter. Dna and Cell Biology. 9: 111-8. PMID 2188656  0.44
1989 Szczypka MS, Thiele DJ. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription Molecular and Cellular Biology. 9: 421-429. PMID 2651899  0.44
1989 Huibregtse JM, Engelke DR, Thiele DJ. Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences Proceedings of the National Academy of Sciences of the United States of America. 86: 65-69. PMID 2643107  0.44
1988 Thiele DJ. ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene Molecular and Cellular Biology. 8: 2745-2752. PMID 3043194  0.44
1987 Thiele DJ, Wright CF, Walling MJ, Hamer DH. Function and regulation of yeast copperthionein. Experientia. Supplementum. 52: 423-9. PMID 2959531  0.44
1986 Thiele DJ, Hamer DH. Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene. Molecular and Cellular Biology. 6: 1158-63. PMID 3537699  0.44
1986 Thiele DJ, Walling MJ, Hamer DH. Mammalian metallothionein is functional in yeast. Science (New York, N.Y.). 231: 854-6. PMID 3080806  0.44
1985 Hamer DH, Thiele DJ, Lemontt JE. Function and autoregulation of yeast copperthionein. Science (New York, N.Y.). 228: 685-90. PMID 3887570  0.44
1984 Thiele DJ, Hannig EM, Leibowitz MJ. Genome structure and expression of a defective interfering mutant of the killer virus of yeast Virology. 137: 20-31. PMID 6382788 DOI: 10.1016/0042-6822(84)90004-7  0.44
1984 Thiele DJ, Hannig EM, Leibowitz MJ. Multiple L double-stranded RNA species of Saccharomyces cerevisiae: evidence for separate encapsidation Molecular and Cellular Biology. 4: 92-100. PMID 6366515  0.44
1984 Hannig EM, Thiele DJ, Leibowitz MJ. Saccharomyces cerevisiae killer virus transcripts contain template-coded polyadenylate tracts Molecular and Cellular Biology. 4: 101-109. PMID 6199660  0.44
1982 Thiele DJ, Wang RW, Leibowitz MJ. Separation and sequence of the 3′ termini of M double-stranded RNA from killer yeast Nucleic Acids Research. 10: 1661-1678. PMID 7041093 DOI: 10.1093/nar/10.5.1661  0.44
1982 Thiele DJ, Leibowitz MJ. Structural and functional analysis of separated strands of killer double-stranded RNA of yeast Nucleic Acids Research. 10: 6903-6918. PMID 6757869 DOI: 10.1093/nar/10.21.6903  0.44
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