David Randell Manning - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Pharmacology, Biochemistry

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Manning DR, Shen F, Riobo NA. Evaluating the Activity of Smoothened Toward G Proteins Using [³⁵S]Guanosine 5'-(3-O-thio)triphosphate ([³⁵S]GTPγS). Methods in Molecular Biology (Clifton, N.J.). 1322: 35-44. PMID 26179037 DOI: 10.1007/978-1-4939-2772-2_4  1
2013 Shen F, Cheng L, Douglas AE, Riobo NA, Manning DR. Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Molecular Pharmacology. 83: 691-7. PMID 23292797 DOI: 10.1124/mol.112.082511  1
2011 Polizio AH, Chinchilla P, Chen X, Manning DR, Riobo NA. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Science Signaling. 4: pt7. PMID 22114142 DOI: 10.1126/scisignal.2002396  1
2011 Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. The Journal of Biological Chemistry. 286: 30714-22. PMID 21757753 DOI: 10.1074/jbc.M111.219279  1
2011 Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. The Journal of Biological Chemistry. 286: 19589-96. PMID 21474452 DOI: 10.1074/jbc.M110.197111  1
2010 Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution. Molecular Pharmacology. 78: 767-77. PMID 20664004 DOI: 10.1124/mol.110.066340  1
2009 Zhang L, Brass LF, Manning DR. The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Molecular Pharmacology. 75: 235-41. PMID 18952767 DOI: 10.1124/mol.108.050906  1
2007 Riobo NA, Manning DR. Pathways of signal transduction employed by vertebrate Hedgehogs. The Biochemical Journal. 403: 369-79. PMID 17419683 DOI: 10.1042/BJ20061723  1
2006 Riobo NA, Saucy B, Dilizio C, Manning DR. Activation of heterotrimeric G proteins by Smoothened. Proceedings of the National Academy of Sciences of the United States of America. 103: 12607-12. PMID 16885213 DOI: 10.1073/pnas.0600880103  1
2006 Zhang L, DiLizio C, Kim D, Smyth EM, Manning DR. The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Molecular Pharmacology. 69: 1433-40. PMID 16418336 DOI: 10.1124/mol.105.019703  1
2005 Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends in Pharmacological Sciences. 26: 146-54. PMID 15749160 DOI: 10.1016/j.tips.2005.01.007  1
2003 Manning DR. Evidence mounts for receptor-independent activation of heterotrimeric G proteins normally in vivo: positioning of the mitotic spindle in C. elegans. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe35. PMID 12928525 DOI: 10.1126/stke.2003.196.pe35  1
2002 Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR, Woulfe D, Brass LF. Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. The Journal of Biological Chemistry. 277: 46035-42. PMID 12297509 DOI: 10.1074/jbc.M208519200  1
2002 Page ME, Cryan JF, Sullivan A, Dalvi A, Saucy B, Manning DR, Lucki I. Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. The Journal of Pharmacology and Experimental Therapeutics. 302: 1220-7. PMID 12183683 DOI: 10.1124/jpet.102.034280  1
2002 Manning DR. Measures of efficacy using G proteins as endpoints: differential engagement of G proteins through single receptors. Molecular Pharmacology. 62: 451-2. PMID 12181420 DOI: 10.1124/mol.62.3.451  1
2002 Siehler S, Manning DR. Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. Biochimica Et Biophysica Acta. 1582: 94-9. PMID 12069815 DOI: 10.1016/S1388-1981(02)00142-7  1
2002 Windh RT, Manning DR. Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding. Methods in Enzymology. 344: 3-14. PMID 11771391 DOI: 10.1016/S0076-6879(02)44702-7  1
2002 Windh RT, Manning DR. Expression of G protein-coupled receptors and G proteins in Sf9 cells: analysis of coupling by radioligand binding. Methods in Enzymology. 343: 417-29. PMID 11665582 DOI: 10.1016/S0076-6879(02)43149-7  1
2001 Siehler S, Wang Y, Fan X, Windh RT, Manning DR. Sphingosine 1-phosphate activates nuclear factor-κB through Edg receptors: Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells Journal of Biological Chemistry. 276: 48733-48739. PMID 11673450 DOI: 10.1074/jbc.M011072200  1
2001 Chen CA, Manning DR. Regulation of G proteins by covalent modification. Oncogene. 20: 1643-52. PMID 11313912 DOI: 10.1038/sj.onc.1204185  1
2000 Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. The Journal of Biological Chemistry. 275: 32129-34. PMID 10906137 DOI: 10.1074/jbc.M004577200  1
2000 Chen CA, Manning DR. Regulation of galpha i palmitoylation by activation of the 5-hydroxytryptamine-1A receptor. The Journal of Biological Chemistry. 275: 23516-22. PMID 10818105 DOI: 10.1074/jbc.M003439200  1
1999 Wang Y, Windh RT, Chen CA, Manning DR. N-Myristoylation and betagamma play roles beyond anchorage in the palmitoylation of the G protein alpha(o) subunit. The Journal of Biological Chemistry. 274: 37435-42. PMID 10601316 DOI: 10.1074/jbc.274.52.37435  1
1999 Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. The Journal of Biological Chemistry. 274: 27351-8. PMID 10488065 DOI: 10.1074/jbc.274.39.27351  1
1999 Shahrestanifar M, Fan X, Manning DR. Lysophosphatidic acid activates NF-κB in fibroblasts. A requirement for multiple inputs Journal of Biological Chemistry. 274: 3828-3833. PMID 9920937 DOI: 10.1074/jbc.274.6.3828  1
1997 Barr AJ, Manning DR. Agonist-independent activation of G(z) by the 5-hydroxytryptamine(1A) receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists Journal of Biological Chemistry. 272: 32979-32987. PMID 9407078 DOI: 10.1074/jbc.272.52.32979  1
1997 Cowen DS, Molinoff PB, Manning DR. 5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells. Molecular Pharmacology. 52: 221-6. PMID 9271344  1
1997 Brass LF, Manning DR, Cichowski K, Abrams CS. Signaling through G proteins in platelets: To the integrins and beyond Thrombosis and Haemostasis. 78: 581-589. PMID 9198220  1
1997 Barr AJ, Brass LF, Manning DR. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling Journal of Biological Chemistry. 272: 2223-2229. PMID 8999927 DOI: 10.1074/jbc.272.4.2223  1
1997 Brass LF, Poncz M, Manning DR. G Proteins and the Early Events of Platelet Activation Advances in Molecular and Cell Biology. 18: 179-195. DOI: 10.1016/S1569-2558(08)60415-4  1
1996 Cowen DS, Sowers RS, Manning DR. Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis. The Journal of Biological Chemistry. 271: 22297-300. PMID 8798386 DOI: 10.1074/jbc.271.37.22297  1
1996 Hallak H, Lounsbury KM, Manning DR. [3] Site-directed mutagenesis of G protein α subunits: Analysis of αz phosphorylation and fatty acid acylation Methods in Neurosciences. 29: 34-49. DOI: 10.1016/S1043-9471(96)80039-5  1
1995 Butkerait P, Zheng Y, Hallak H, Graham TE, Miller HA, Burris KD, Molinoff PB, Manning DR. Expression of the human 5-hydroxytryptamine1A receptor in Sf9 cells. Reconstitution of a coupled phenotype by co-expression of mammalian G protein subunits. The Journal of Biological Chemistry. 270: 18691-9. PMID 7629202  1
1994 Hallak H, Brass LF, Manning DR. Failure to myristoylate the α subunit of Gz is correlated with an inhibition of palmitoylation and membrane attachment, but has no affect on phosphorylation by protein kinase C Journal of Biological Chemistry. 269: 4571-4576. PMID 8308028  1
1994 Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts Journal of Biological Chemistry. 269: 8483-8487. PMID 8132575  1
1994 Hallak H, Muszbek L, Laposata M, Belmonte E, Brass LF, Manning DR. Covalent binding of arachidonate to G protein α subunits of human platelets Journal of Biological Chemistry. 269: 4713-4716. PMID 8106438  1
1993 Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, Williamson JR. Epidermal growth factor-mediated signaling of Gi-protein to activation of phospholipases in rat-cultured hepatocytes Journal of Biological Chemistry. 268: 3739-3746. PMID 8429049  1
1993 Lounsbury KM, Schlegel B, Poncz M, Brass LF, Manning DR. Analysis of Gzα by site-directed mutagenesis: Sites and specificity of protein kinase C-dependent phosphorylation Journal of Biological Chemistry. 268: 3494-3498. PMID 8429024  1
1993 Vardi N, Matesic DF, Manning DR, Liebman PA, Sterling P. Identification of a G-protein in depolarizing rod bipolar cells. Visual Neuroscience. 10: 473-8. PMID 8388245 DOI: 10.1017/S0952523800004697  1
1993 Brass LF, Hoxie JA, Manning DR. Signaling through G proteins and G protein-coupled receptors during platelet activation Thrombosis and Haemostasis. 70: 217-223. PMID 8236108  1
1993 Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis M. Agonist receptors and G proteins as mediators of platelet activation Advances in Experimental Medicine and Biology. 344: 17-36. PMID 8209785  1
1991 Lounsbury KM, Casey PJ, Brass LF, Manning DR. Phosphorylation of Gz in human platelets: Selectivity and site of modification Journal of Biological Chemistry. 266: 22051-22056. PMID 1939224  1
1991 Gagnon AW, Manning DR, Catani L, Gewirtz A, Poncz M, Brass LF. Identification of Gzα as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes Blood. 78: 1247-1253. PMID 1908722  1
1991 Brass LF, Manning DR, Shattil SJ. GTP-binding proteins and platelet activation Progress in Hemostasis and Thrombosis. 10: 127-174. PMID 1848944  1
1991 Brass LF, Manning DR, Williams AG, Woolkalis MJ, Poncz M. Receptor and G protein-mediated responses to thrombin in HEL cells Journal of Biological Chemistry. 266: 958-965. PMID 1845999  1
1991 Lewis JM, Woolkalis MJ, Gerton GL, Smith RM, Jarett L, Manning DR. Subcellular distribution of the alpha subunit(s) of Gi: visualization by immunofluorescent and immunogold labeling Cell Regulation. 2: 1097-1113. PMID 1801926  1
1991 Matesic DF, Manning DR, Luthin GR. Tissue-dependent association of muscarinic acetylcholine receptors with guanine nucleotide-binding regulatory proteins Molecular Pharmacology. 40: 347-353. PMID 1716729  1
1991 Manning DR, Brass LF. The role of GTP-binding proteins in platelet activation Thrombosis and Haemostasis. 66: 393-399. PMID 1665593  1
1991 Marzo KP, Frey MJ, Wilson JR, Liang BT, Manning DR, Lanoce V, Molinoff PB. Beta-adrenergic receptor-G protein-adenylate cyclase complex in experimental canine congestive heart failure produced by rapid ventricular pacing. Circulation Research. 69: 1546-56. PMID 1659503  1
1991 Brass LF, Manning DR. G proteins and low-molecular-weight GTP-binding proteins in platelets Trends in Cardiovascular Medicine. 1: 92-98. DOI: 10.1016/1050-1738(91)90017-9  1
1991 Lewis JM, Woolkalis MJ, Gerton GL, Smith RM, Jarett L, Manning DR. Subcellular distribution of the α subunit(s) of Gi: Visualization by immunofluorescent and immunogold labeling Molecular Biology of the Cell. 2: 1097-1113.  1
1990 Gutierrez GE, Mundy GR, Manning DR, Hewlett EL, Katz MS. Transforming growth factor β enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells Journal of Cellular Physiology. 144: 438-447. PMID 2391378  1
1990 Cooper HS, Manning DR, Wax MB. G protein complement of SV40-transformed ciliary epithelial cells Current Eye Research. 9: 493-499. PMID 2166638 DOI: 10.3109/02713689008999615  1
1990 Lee W, Nicklaus KJ, Manning DR, Wolfe BB. Ontogeny of cortical muscarinic receptor subtypes and muscarinic receptor-mediated responses in rat. The Journal of Pharmacology and Experimental Therapeutics. 252: 482-90. PMID 2156047  1
1990 Williams AG, Woolkalis MJ, Poncz M, Manning DR, Gerwirtz AM, Brass LF. Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells Blood. 76: 721-730. PMID 2116927  1
1990 Manning DR. G proteins: Linkages with amine receptors Neuropsychopharmacology. 3: 447-455. PMID 1964050  1
1989 Wilde MW, Carlson KE, Manning DR, Zigmond SH. Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant. The Journal of Biological Chemistry. 264: 190-6. PMID 2535838  1
1989 Matesic DF, Manning DR, Wolfe BB, Luthin GR. Pharmacological and biochemical characterization of complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein. The Journal of Biological Chemistry. 264: 21638-45. PMID 2513323  1
1989 Carlson KE, Brass LF, Manning DR. Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than G(i) in human platelets Journal of Biological Chemistry. 264: 13298-13305. PMID 2502548  1
1988 Brass LF, Woolkalis MJ, Manning DR. Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase Journal of Biological Chemistry. 263: 5348-5355. PMID 2833506  1
1987 Woolkalis MJ, Manning DR. Structural characteristics of the 35- and 36-kDa forms of the β subunit common to GTP-binding regulatory proteins Molecular Pharmacology. 32: 1-6. PMID 3110591  1
1986 Carlson KE, Woolkalis MJ, Newhouse MG, Manning DR. Fractionation of the β subunit common to guanine nucleotide-binding regulatory proteins with the cytoskeleton Molecular Pharmacology. 30: 463-468. PMID 3095628  1
1986 Mumby SM, Kahn RA, Manning DR, Gilman AG. Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins Proceedings of the National Academy of Sciences of the United States of America. 83: 265-269. PMID 3079909  1
1986 Woolkalis MJ, Nakada MT, Manning DR. Alterations in components of adenylate cyclase associated with transformation of chicken embryo fibroblasts by Rous sarcoma virus Journal of Biological Chemistry. 261: 3408-3413. PMID 3005290  1
1985 Land MD, Cox DJ, Manning DR, Reeck GR. Physical properties of chicken erythrocyte HMG-1, HMG-2 and HMG-E Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 831: 207-212. PMID 4041467 DOI: 10.1016/0167-4838(85)90037-8  1
1984 Manning DR, Fraser BA, Kahn RA, Gilman AG. ADP-ribosylation of transducin by islet-activating protein. Identification of asparagine as the site of ADP-ribosylation Journal of Biological Chemistry. 259: 749-756. PMID 6582063  1
1983 Manning DR, Stull JT. Assessment of Ca2+-calmodulin formation in intact vertebrate skeletal muscle Methods in Enzymology. 74-82. PMID 6645972  1
1983 Manning DR, Gilman AG. The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins Journal of Biological Chemistry. 258: 7059-7063. PMID 6304074  1
1982 Manning DR, Stull JT. Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle The American Journal of Physiology. 242. PMID 7065172  1
1980 Stull JT, Manning DR, High CW, Blumenthal DK. Phosphorylation of contractile proteins in heart and skeletal muscle Federation Proceedings. 39: 1552-1557. PMID 7364051  1
1980 Manning DR, DiSalvo J, Stull JT. Protein phosphorylation: Quantitative analysis in vivo and in intact cell systems Molecular and Cellular Endocrinology. 19: 1-19. PMID 6248400 DOI: 10.1016/0303-7207(80)90026-X  1
1979 Manning DR, Stull JT. Myosin light chain phosphorylation and phosphorylase a activity in rat extensor digitorum longus muscle Biochemical and Biophysical Research Communications. 90: 164-170. PMID 496969 DOI: 10.1016/0006-291X(79)91604-8  1
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