| Year |
Citation |
Score |
| 2019 |
Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Retraction: Sensitizing Estrogen Receptor-negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor. Molecular Cancer Therapeutics. 18: 869. PMID 30936413 DOI: 10.1158/1535-7163.Mct-19-0151 |
0.587 |
|
| 2017 |
Sugimoto Y, Sawant DB, Fisk HA, Mao L, Li C, Chettiar S, Li PK, Darby MV, Brueggemeier RW. Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorganic & Medicinal Chemistry. PMID 28259529 DOI: 10.1016/J.Bmc.2017.02.030 |
0.578 |
|
| 2016 |
Eloy JO, Petrilli R, Brueggemeier RW, Marchetti JM, Lee RJ. Rapamycin-loaded immunoliposomes functionalized with trastuzumab: a strategy to enhance cytotoxicity to HER2-positive breast cancer cells. Anti-Cancer Agents in Medicinal Chemistry. PMID 27225450 DOI: 10.2174/1871520616666160526103432 |
0.413 |
|
| 2015 |
Kesinger JW, Mehta M, Lerner MR, Brackett DJ, Brueggemeier RW, Li PK, Pento JT. Oncolytic potential of a novel KGFR tyrosine kinase inhibitor using a KGFR-selective breast cancer xenograft model. Anticancer Research. 35: 47-52. PMID 25550534 |
0.41 |
|
| 2015 |
Brueggemeier RW. Analogs and Antagonists of Male Sex Hormones Reviews in Cell Biology and Molecular Medicine. 1: 308-380. DOI: 10.1002/3527600906.Mcb.200500066.Pub2 |
0.408 |
|
| 2013 |
Piao L, Li H, Teng L, Yung BC, Sugimoto Y, Brueggemeier RW, Lee RJ. Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer. Nanomedicine : Nanotechnology, Biology, and Medicine. 9: 122-9. PMID 22542825 DOI: 10.1016/J.Nano.2012.03.008 |
0.434 |
|
| 2012 |
Tenchov B, Sugimoto Y, Koynova R, Brueggemeier RW, Lee RJ. Highly efficient cationic ethylphosphatidylcholine siRNA carrier for GFP suppression in modified breast cancer cells. Anticancer Research. 32: 2563-6. PMID 22753714 |
0.422 |
|
| 2012 |
Zhou C, Mao Y, Sugimoto Y, Zhang Y, Kanthamneni N, Yu B, Brueggemeier RW, Lee LJ, Lee RJ. SPANosomes as delivery vehicles for small interfering RNA (siRNA). Molecular Pharmaceutics. 9: 201-10. PMID 22149175 DOI: 10.1021/Mp200426H |
0.318 |
|
| 2011 |
Díaz-Cruz ES, Sugimoto Y, Gallicano GI, Brueggemeier RW, Furth PA. Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer Cancer Research. 71: 5477-5487. PMID 21840986 DOI: 10.1158/0008-5472.CAN-10-4652 |
0.785 |
|
| 2011 |
Lustberg MB, Povoski SP, Zhao W, Ziegler RM, Sugimoto Y, Ruppert AS, Lehman AM, Shiels DR, Mrozek E, Ramaswamy B, Layman RM, Brueggemeier RW, Shapiro CL. Phase II trial of neoadjuvant exemestane in combination with celecoxib in postmenopausal women who have breast cancer. Clinical Breast Cancer. 11: 221-7. PMID 21729671 DOI: 10.1016/J.Clbc.2011.03.022 |
0.482 |
|
| 2010 |
Mehta M, Kesinger JW, Zang XP, Lerner ML, Brackett DJ, Brueggemeier RW, Li PK, Pento JT. Influence of novel KGFR tyrosine kinase inhibitors on KGF-mediated proliferation of breast cancer. Anticancer Research. 30: 4883-9. PMID 21187466 |
0.476 |
|
| 2010 |
Zheng Y, Yu B, Weecharangsan W, Piao L, Darby M, Mao Y, Koynova R, Yang X, Li H, Xu S, Lee LJ, Sugimoto Y, Brueggemeier RW, Lee RJ. Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells. International Journal of Pharmaceutics. 390: 234-41. PMID 20156537 DOI: 10.1016/J.Ijpharm.2010.02.008 |
0.337 |
|
| 2010 |
Brueggemeier RW, Su B, Darby MV, Sugimoto Y. Selective regulation of aromatase expression for drug discovery. The Journal of Steroid Biochemistry and Molecular Biology. 118: 207-10. PMID 19931613 DOI: 10.1016/J.Jsbmb.2009.11.009 |
0.604 |
|
| 2010 |
Pento T, Meghna M, Kesinger J, Brueggemeier R, Hackett J, Xiao Z, Lerner, Brackett D, Awasthi V, Li P. Abstract P6-15-08: KGFR Tyrosine Kinase Inhibitors for the Treatment of Breast Cancer Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P6-15-08 |
0.568 |
|
| 2010 |
Brueggemeier RW, Li P. Fundamentals of Steroid Chemistry and Biochemistry Burger's Medicinal Chemistry and Drug Discovery. 1-34. DOI: 10.1002/0471266949.Bmc053.Pub2 |
0.414 |
|
| 2009 |
Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochemistry Letters. 2: 29-33. PMID 20161072 DOI: 10.1016/J.Phytol.2008.10.009 |
0.382 |
|
| 2009 |
Diaz‐Cruz ES, Nakles RE, Sugimoto Y, Brueggemeier RW, Furth PA. Abstract A26: Aromatase over‐expression results in the development of ductal growth abnormalities in the mammary gland of a conditional transgenic mouse model Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A26 |
0.52 |
|
| 2008 |
Miller WR, Bartlett J, Brodie AM, Brueggemeier RW, di Salle E, Lønning PE, Llombart A, Maass N, Maudelonde T, Sasano H, Goss PE. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? The Oncologist. 13: 829-37. PMID 18695261 DOI: 10.1634/Theoncologist.2008-0055 |
0.457 |
|
| 2008 |
Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Natural products as aromatase inhibitors. Anti-Cancer Agents in Medicinal Chemistry. 8: 646-82. PMID 18690828 DOI: 10.2174/187152008785133092 |
0.447 |
|
| 2008 |
Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. Journal of Natural Products. 71: 1161-6. PMID 18558747 DOI: 10.1021/Np8000255 |
0.519 |
|
| 2008 |
Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Molecular Cancer Therapeutics. 7: 800-8. PMID 18413793 DOI: 10.1158/1535-7163.MCT-07-0434 |
0.503 |
|
| 2008 |
Su B, Darby MV, Brueggemeier RW. Synthesis and biological evaluation of novel sulfonanilide compounds as antiproliferative agents for breast cancer. Journal of Combinatorial Chemistry. 10: 475-83. PMID 18380483 DOI: 10.1021/Cc700138N |
0.528 |
|
| 2008 |
Su B, Tian R, Darby MV, Brueggemeier RW. Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification. Journal of Medicinal Chemistry. 51: 1126-35. PMID 18271519 DOI: 10.1021/Jm701107H |
0.623 |
|
| 2008 |
Su B, Mershon SM, Stonerock LA, Curley RW, Brueggemeier RW. 4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 109: 40-6. PMID 18248980 DOI: 10.1016/J.Jsbmb.2007.12.005 |
0.594 |
|
| 2008 |
Su B, Díaz-Cruz ES, Landini S, Brueggemeier RW. Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition. Steroids. 73: 104-11. PMID 18045633 DOI: 10.1016/J.Steroids.2007.09.011 |
0.823 |
|
| 2008 |
Davis DD, Díaz-Cruz ES, Landini S, Kim YW, Brueggemeier RW. Evaluation of synthetic isoflavones on cell proliferation, estrogen receptor binding affinity, and apoptosis in human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 108: 23-31. PMID 17962013 DOI: 10.1016/J.Jsbmb.2007.07.001 |
0.856 |
|
| 2008 |
Diaz-Cruz E, Furth P, Brueggemeier R, Sugimoto Y. Abstract B70: A conditional aromatase over-expressing in the mammary gland transgenic mouse as a potential model in cancer prevention research Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-B70 |
0.788 |
|
| 2007 |
Hackett J, Xiao Z, Zang XP, Lerner ML, Brackett DJ, Brueggemeier RW, Li PK, Pento JT. Development of keratinocyte growth factor receptor tyrosine kinase inhibitors for the treatment of cancer. Anticancer Research. 27: 3801-6. PMID 18225535 |
0.459 |
|
| 2007 |
Brueggemeier RW, Su B, Sugimoto Y, Díaz-Cruz ES, Davis DD. Aromatase and COX in breast cancer: enzyme inhibitors and beyond. The Journal of Steroid Biochemistry and Molecular Biology. 106: 16-23. PMID 17616393 DOI: 10.1016/J.Jsbmb.2007.05.021 |
0.819 |
|
| 2007 |
Su B, Landini S, Davis DD, Brueggemeier RW. Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. Journal of Medicinal Chemistry. 50: 1635-44. PMID 17315855 DOI: 10.1021/Jm061133J |
0.629 |
|
| 2007 |
Shapiro CL, Povoski SP, Jiminez R, Dehart J, Ottman S, Shiels DR, Xiaobia L, Brueggemeier R. Phase II trial of neoadjuvant exemestane [EXE] and celecoxib [CELE] in breast cancer: Results of biomarkers Journal of Clinical Oncology. 25: 11056-11056. DOI: 10.1200/Jco.2007.25.18_Suppl.11056 |
0.479 |
|
| 2006 |
Brueggemeier RW. Update on the use of aromatase inhibitors in breast cancer. Expert Opinion On Pharmacotherapy. 7: 1919-30. PMID 17020418 DOI: 10.1517/14656566.7.14.1919 |
0.581 |
|
| 2006 |
Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Molecular Pharmacology. 70: 1534-41. PMID 16887935 DOI: 10.1124/Mol.106.023911 |
0.528 |
|
| 2006 |
Díaz-Cruz ES, Brueggemeier RW. Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer. Anti-Cancer Agents in Medicinal Chemistry. 6: 221-32. PMID 16712450 DOI: 10.2174/187152006776930873 |
0.823 |
|
| 2006 |
Balunas MJ, Su B, Landini S, Brueggemeier RW, Kinghorn AD. Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. Journal of Natural Products. 69: 700-3. PMID 16643058 DOI: 10.1021/Np050513P |
0.365 |
|
| 2006 |
Brueggemeier RW, Díaz-Cruz ES. Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. Minerva Endocrinologica. 31: 13-26. PMID 16498361 |
0.503 |
|
| 2006 |
Su B, Diaz-Cruz ES, Landini S, Brueggemeier RW. Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. Journal of Medicinal Chemistry. 49: 1413-9. PMID 16480277 DOI: 10.1021/Jm051126F |
0.835 |
|
| 2006 |
Brueggemeier RW. Sex Hormones (Male): Analogs and Antagonists Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200500066 |
0.42 |
|
| 2005 |
Su B, Hackett JC, Díaz-Cruz ES, Kim YW, Brueggemeier RW. Lead optimization of 7-benzyloxy 2-(4'-pyridylmethyl)thio isoflavone aromatase inhibitors. Bioorganic & Medicinal Chemistry. 13: 6571-7. PMID 16125392 DOI: 10.1016/J.Bmc.2005.07.038 |
0.849 |
|
| 2005 |
Brueggemeier RW, Díaz-Cruz ES, Li PK, Sugimoto Y, Lin YC, Shapiro CL. Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology. 95: 129-36. PMID 15964185 DOI: 10.1016/J.Jsbmb.2005.04.013 |
0.815 |
|
| 2005 |
Hackett JC, Kim YW, Su B, Brueggemeier RW. Synthesis and characterization of azole isoflavone inhibitors of aromatase. Bioorganic & Medicinal Chemistry. 13: 4063-70. PMID 15911319 DOI: 10.1016/J.Bmc.2005.03.050 |
0.615 |
|
| 2005 |
Brueggemeier RW, Hackett JC, Diaz-Cruz ES. Aromatase inhibitors in the treatment of breast cancer. Endocrine Reviews. 26: 331-45. PMID 15814851 DOI: 10.1210/Er.2004-0015 |
0.818 |
|
| 2005 |
Díaz-Cruz ES, Shapiro CL, Brueggemeier RW. Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. The Journal of Clinical Endocrinology and Metabolism. 90: 2563-70. PMID 15687328 DOI: 10.1210/Jc.2004-2029 |
0.815 |
|
| 2005 |
Huang JW, Shiau CW, Yang YT, Kulp SK, Chen KF, Brueggemeier RW, Shapiro CL, Chen CS. Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells. Molecular Pharmacology. 67: 1342-8. PMID 15653552 DOI: 10.1124/Mol.104.007732 |
0.414 |
|
| 2004 |
Kim YW, Hackett JC, Brueggemeier RW. Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. Journal of Medicinal Chemistry. 47: 4032-40. PMID 15267241 DOI: 10.1021/Jm0306024 |
0.743 |
|
| 2004 |
Brueggemeier RW. Aromatase inhibitors: new endocrine treatment of breast cancer. Seminars in Reproductive Medicine. 22: 31-43. PMID 15083379 DOI: 10.1055/S-2004-823025 |
0.589 |
|
| 2004 |
Mobley JA, Brueggemeier RW. Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer. Carcinogenesis. 25: 3-9. PMID 14514655 DOI: 10.1093/Carcin/Bgg175 |
0.702 |
|
| 2003 |
Brueggemeier RW, Richards JA, Petrel TA. Aromatase and cyclooxygenases: Enzymes in breast cancer Journal of Steroid Biochemistry and Molecular Biology. 86: 501-507. PMID 14623550 DOI: 10.1016/S0960-0760(03)00380-7 |
0.747 |
|
| 2003 |
Richards JA, Brueggemeier RW. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes Journal of Clinical Endocrinology and Metabolism. 88: 2810-2816. PMID 12788892 DOI: 10.1210/Jc.2002-021475 |
0.731 |
|
| 2003 |
Kim YW, Mobley JA, Brueggemeier RW. Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-ones containing a basic side chain. Bioorganic & Medicinal Chemistry Letters. 13: 1475-8. PMID 12668015 DOI: 10.1002/CHIN.200329120 |
0.733 |
|
| 2003 |
Petrel TA, Brueggemeier RW. Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines. Journal of Cellular Biochemistry. 88: 181-90. PMID 12461787 DOI: 10.1002/Jcb.10353 |
0.442 |
|
| 2003 |
Brueggemeier RW. Male Sex Hormones, Analogs, and Antagonists Burger's Medicinal Chemistry and Drug Discovery. 153-218. DOI: 10.1002/0471266949.Bmc055 |
0.422 |
|
| 2002 |
Coleman RS, Burk CH, Navarro A, Brueggemeier RW, Diaz-Cruz ES. Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures. Organic Letters. 4: 3545-8. PMID 12323065 DOI: 10.1021/Ol0267275 |
0.751 |
|
| 2002 |
Brueggemeier RW. Overview of the pharmacology of the aromatase inactivator exemestane. Breast Cancer Research and Treatment. 74: 177-85. PMID 12186378 DOI: 10.1023/A:1016121822916 |
0.596 |
|
| 2002 |
Brueggemeier RW. Aromatase inhibitors in breast cancer therapy. Expert Review of Anticancer Therapy. 2: 181-91. PMID 12113240 DOI: 10.1586/14737140.2.2.181 |
0.577 |
|
| 2002 |
Mobley JA, Brueggemeier RW. Increasing the DNA damage threshold in breast cancer cells. Toxicology and Applied Pharmacology. 180: 219-26. PMID 12009861 DOI: 10.1006/Taap.2002.9391 |
0.666 |
|
| 2002 |
Richards JA, Petrel TA, Brueggemeier RW. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells Journal of Steroid Biochemistry and Molecular Biology. 80: 203-212. PMID 11897504 DOI: 10.1016/S0960-0760(01)00187-X |
0.742 |
|
| 2002 |
Kim YW, Brueggemeier RW. A convenient one-pot synthesis of 2-(alkylthio)isoflavones from deoxybenzoins using a phase transfer catalyst Tetrahedron Letters. 43: 6113-6115. DOI: 10.1016/S0040-4039(02)01342-4 |
0.433 |
|
| 2001 |
Brueggemeier RW, Richards JA, Joomprabutra S, Bhat AS, Whetstone JL. Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents Journal of Steroid Biochemistry and Molecular Biology. 79: 75-84. PMID 11850210 DOI: 10.1016/S0960-0760(01)00127-3 |
0.803 |
|
| 2001 |
Brueggemeier RW, Gu X, Mobley JA, Joomprabutra S, Bhat AS, Whetstone JL. Effects of phytoestrogens and synthetic combinatorial libraries on aromatase, estrogen biosynthesis, and metabolism. Annals of the New York Academy of Sciences. 948: 51-66. PMID 11795395 DOI: 10.1111/J.1749-6632.2001.Tb03986.X |
0.799 |
|
| 2001 |
Brueggemeier RW, Bhat AS, Lovely CJ, Coughenour HD, Joomprabutra S, Weitzel DH, Vandre DD, Yusuf F, Burak WE. 2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 78: 145-56. PMID 11566439 DOI: 10.1016/S0960-0760(01)00090-5 |
0.781 |
|
| 2001 |
Brueggemeier RW. Aromatase, aromatase inhibitors, and breast cancer American Journal of Therapeutics. 8: 333-344. PMID 11550075 DOI: 10.1097/00045391-200109000-00007 |
0.576 |
|
| 2001 |
Lynch MA, Petrel TA, Song H, Knobloch TJ, Casto BC, Ramljak D, Anderson LM, Degroff V, Stoner GD, Brueggemeier RW, Weghorst CM. Responsiveness to transforming growth factor-β (TGF-β)-mediated growth inhibition is a function of membrane-bound TGF-β type II receptor in human breast cancer cells Gene Expression. 9: 157-171. PMID 11444526 DOI: 10.3727/000000001783992560 |
0.367 |
|
| 2000 |
Bhat AS, Whetstone JL, Brueggemeier RW. A method for the rapid synthesis of benzopyrone libraries employing a resin capture strategy. Journal of Combinatorial Chemistry. 2: 597-9. PMID 11126288 DOI: 10.1021/Cc000042J |
0.747 |
|
| 2000 |
Zheng J, Kulp SK, Zhang Y, Sugimoto Y, Dayton MA, Govindan MV, Brueggemeier RW, Lin YC. 17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells. Anticancer Research. 20: 11-9. PMID 10769629 |
0.376 |
|
| 1999 |
Quinn AL, Burak WE, Brueggemeier RW. Effects of matrix components on aromatase activity in breast stromal cells in culture Journal of Steroid Biochemistry and Molecular Biology. 70: 249-256. PMID 10622415 DOI: 10.1016/S0960-0760(99)00113-2 |
0.505 |
|
| 1999 |
Harris RE, Robertson FM, Abou-Issa HM, Farrar WB, Brueggemeier R. Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer. Medical Hypotheses. 52: 291-2. PMID 10465664 DOI: 10.1054/Mehy.1998.0009 |
0.411 |
|
| 1999 |
Brueggemeier RW, Quinn AL, Parrett ML, Joarder FS, Harris RE, Robertson FM. Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens. Cancer Letters. 140: 27-35. PMID 10403538 DOI: 10.1016/S0304-3835(99)00050-6 |
0.579 |
|
| 1999 |
Mobley JA, Bhat AS, Brueggemeier RW. Measurement of oxidative DNA damage by catechol estrogens and analogues in vitro. Chemical Research in Toxicology. 12: 270-7. PMID 10077490 DOI: 10.1021/Tx980128I |
0.595 |
|
| 1999 |
Bhat AS, Whetstone JL, Brueggemeier RW. Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries Tetrahedron Letters. 40: 2469-2472. DOI: 10.1016/S0040-4039(99)00279-8 |
0.754 |
|
| 1998 |
Zhang Y, Kulp SK, Sugimoto Y, Brueggemeier RW, Lin YC. The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor beta1 production. International Journal of Oncology. 13: 1291-7. PMID 9824647 DOI: 10.3892/Ijo.13.6.1291 |
0.49 |
|
| 1998 |
Zhang Y, Kulp SK, Sugimoto Y, Farrar WB, Brueggemeier RW, Lin YC. Keratinocyte growth factor (KGF) induces aromatase activity in cultured MCF-7 human breast cancer cells. Anticancer Research. 18: 2541-6. PMID 9703907 |
0.525 |
|
| 1998 |
Zhang Y, Sugimoto Y, Kulp SK, Farrar WB, Brueggemeier RW, Lin YC. Estrogen-induced keratinocyte growth factor mRNA expression in normal and cancerous human breast cells. Oncology Reports. 5: 577-83. PMID 9538155 DOI: 10.3892/Or.5.3.577 |
0.563 |
|
| 1997 |
Lovely CJ, Bhat AS, Coughenour HD, Gilbert NE, Brueggemeier RW. Synthesis and biological evaluation of 4-(hydroxyalkyl)estradiols and related compounds. Journal of Medicinal Chemistry. 40: 3756-64. PMID 9371241 DOI: 10.1021/Jm9701684 |
0.803 |
|
| 1997 |
Brueggemeier RW, O'Reilly JM, Lovely CJ, Ward PJ, Quinn AL, Baker D, Darby MV, Gu XJ, Gilbert NE. Biochemistry and pharmacology of 7α-substituted androstenediones as aromatase inhibitors Journal of Steroid Biochemistry and Molecular Biology. 61: 247-254. PMID 9365197 DOI: 10.1016/S0960-0760(97)80019-2 |
0.677 |
|
| 1997 |
Brueggemeier RW, Gilbert NE, Gu X, O'Reilly JM, Lovely CJ. Aromatase inhibition in JAr choriocarcinoma cells by 7α-arylaliphatic androgens Journal of Steroid Biochemistry and Molecular Biology. 61: 73-77. PMID 9328212 DOI: 10.1016/S0960-0760(97)00006-X |
0.668 |
|
| 1997 |
Burak WE, Quinn AL, Farrar WB, Brueggemeier RW. Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase Breast Cancer Research and Treatment. 44: 57-64. PMID 9164678 DOI: 10.1023/A:1005782311558 |
0.577 |
|
| 1996 |
O'Reilly JM, Brueggemeier RW. 7α-Arylaliphatic androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase Journal of Steroid Biochemistry and Molecular Biology. 59: 93-102. PMID 9009242 DOI: 10.1016/S0960-0760(96)00087-8 |
0.41 |
|
| 1996 |
Shidaifat F, Canatan H, Kulp SK, Sugimoto Y, Chang WY, Zhang Y, Brueggemeier RW, Somers WJ, Lin YC. Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. Cancer Letters. 107: 37-44. PMID 8913264 DOI: 10.1016/0304-3835(96)04340-6 |
0.365 |
|
| 1996 |
Lovely CJ, Gilbert NE, Liberto MM, Sharp DW, Lin YC, Brueggemeier RW. 2-(Hydroxyalkyl)estradiols: synthesis and biological evaluation. Journal of Medicinal Chemistry. 39: 1917-23. PMID 8627615 DOI: 10.1021/Jm9508245 |
0.709 |
|
| 1996 |
O'Reilly JM, Brueggemeier RW. Development of steroidal and nonsteroidal inhibitors of aromatase for the treatment of hormone-dependent breast cancer Current Medicinal Chemistry. 3: 11-22. |
0.521 |
|
| 1995 |
Beleh MA, Lin YC, Brueggemeier RW. Estrogen metabolism in microsomal, cell, and tissue preparations of kidney and liver from Syrian hamsters Journal of Steroid Biochemistry and Molecular Biology. 52: 479-489. PMID 7748813 DOI: 10.1016/0960-0760(95)00003-I |
0.415 |
|
| 1995 |
O'Reilly JM, Li N, Duax WL, Brueggemeier RW. Synthesis, structure elucidation, and biochemical evaluation of 7α- and 7β-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase Journal of Medicinal Chemistry. 38: 2842-2850. PMID 7636845 DOI: 10.1021/Jm00015A006 |
0.396 |
|
| 1995 |
Gilbert NE, O'Reilly JE, Chang CJG, Lin YC, Brueggemeier RW. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells Life Sciences. 57: 61-67. PMID 7596222 DOI: 10.1016/0024-3205(95)00243-Y |
0.579 |
|
| 1995 |
Lovely CJ, Brueggemeier RW. Synthesis of 7α-substituted androstenediones by a 1,4-conjugate addition approach Bioorganic and Medicinal Chemistry Letters. 5: 2513-2516. DOI: 10.1016/0960-894X(95)00440-5 |
0.587 |
|
| 1994 |
Hu YF, Chang CJG, Brueggemeier RW, Lin YC. Presence of antitumor activities in the milk collected from gossypol-treated dairy cows Cancer Letters. 87: 17-23. PMID 7954365 DOI: 10.1016/0304-3835(94)90404-9 |
0.478 |
|
| 1994 |
Brueggemeier RW. Aromatase inhibitors - mechanisms of steroidal inhibitors Breast Cancer Research and Treatment. 30: 31-42. PMID 7949203 DOI: 10.1007/Bf00682739 |
0.521 |
|
| 1994 |
Lovely CJ, Brueggemeier RW. Synthesis of 2-substituted hydroxyalkyl and aminoalkyl estradiols Tetrahedron Letters. 35: 8735-8738. DOI: 10.1016/S0040-4039(00)78484-X |
0.645 |
|
| 1993 |
Brueggemeier RW, Moh PP, Ebrahimian S, Darby MV. Steroidal inhibitors as chemical probes of the active site of aromatase Journal of Steroid Biochemistry and Molecular Biology. 44: 357-365. PMID 8476749 DOI: 10.1016/0960-0760(93)90239-S |
0.369 |
|
| 1993 |
Beleh MA, Brueggemeier RW, Chang GCJ, Lin YC. Biosynthesis and Secretion of Growth Factor Proteins by Kidney Cells from DES-Treated Syrian Hamsters Biochemical and Biophysical Research Communications. 190: 1029-1036. PMID 8439304 DOI: 10.1006/Bbrc.1993.1152 |
0.306 |
|
| 1993 |
Hu YF, Chang CJG, Brueggemeier RW, Lin YC. Gossypol in hibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells Life Sciences. 53. PMID 8255144 DOI: 10.1016/0024-3205(93)90036-3 |
0.529 |
|
| 1993 |
Ebrahimian S, Chen HH, Brueggemeier RW. Synthesis and biochemical studies of 7α-substituted androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase Steroids. 58: 414-422. PMID 8236327 DOI: 10.1016/0039-128X(93)90081-W |
0.393 |
|
| 1992 |
Brueggemeier RW, Katlic NE, Kenreigh CA, Li PK. Aromatase inhibition by 7-substituted steroids in human choriocarcinoma cell culture Journal of Steroid Biochemistry and Molecular Biology. 41: 85-90. PMID 1734938 DOI: 10.1016/0960-0760(92)90228-B |
0.447 |
|
| 1992 |
Lin YC, Gu Y, Brueggemeier RW, Rikihisa Y. Binding of 3H-gossypol in organelles of cultured bovine luteal cells Life Sciences. 50: 443-447. PMID 1734162 DOI: 10.1016/0024-3205(92)90379-4 |
0.325 |
|
| 1991 |
Gu Y, Li PK, Lin YC, Rikihisa Y, Brueggemeier RW. Gossypolone suppresses progesterone synthesis in bovine luteal cells Journal of Steroid Biochemistry and Molecular Biology. 38: 709-715. PMID 2064986 DOI: 10.1016/0960-0760(91)90082-G |
0.456 |
|
| 1990 |
Brueggemeier RW, Ko T, Katlic NE, Beleh MA, Lin YC. Estrogen metabolism in primary kidney cell cultures from syrian hamsters Journal of Steroid Biochemistry. 36: 325-331. PMID 2391962 DOI: 10.1016/0022-4731(90)90225-H |
0.393 |
|
| 1990 |
Brueggemeier RW, Katlic NE. Aromatase Inhibition by an Enzyme-activated Irreversible Inhibitor in Human Carcinoma Cell Cultures Cancer Research. 50: 3652-3656. PMID 2340513 |
0.328 |
|
| 1990 |
Chen HH, Brueggemeier RW. Synthesis and biochemistry of fluorescent aromatase inhibitors Steroids. 55: 123-127. PMID 2333659 DOI: 10.1016/0039-128X(90)90008-Y |
0.376 |
|
| 1990 |
Li PK, Brueggemeier RW. Synthesis and biochemical studies of 7-substituted 4,6-androstadiene-3,17-diones as aromatase inhibitors Journal of Medicinal Chemistry. 33: 101-105. PMID 2296006 DOI: 10.1021/Jm00163A017 |
0.526 |
|
| 1990 |
Brueggemeier RW, Li PK, Chen HH, Moh PP, Katlic NE. Biochemical and pharmacological development of steroidal inhibitors of aromatase Journal of Steroid Biochemistry and Molecular Biology. 37: 379-385. PMID 2257241 DOI: 10.1016/0960-0760(90)90488-7 |
0.466 |
|
| 1990 |
Li PK, Brueggemeier RW. 7-Substituted 1,4,6-androstatriene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase Journal of Steroid Biochemistry. 36: 533-539. PMID 2214770 DOI: 10.1016/0022-4731(90)90170-W |
0.397 |
|
| 1990 |
Li PK, Brueggemeier RW. 7-substituted steroidal aromatase inhibitors: Structure-activity relationships and molecular modeling Journal of Enzyme Inhibition and Medicinal Chemistry. 4: 113-120. PMID 2098517 DOI: 10.3109/14756369009040732 |
0.405 |
|
| 1989 |
Brueggemeier RW, Singh U. Inhibition of rat liver microsomal estrogen 2-hydroxylase by 2-methoxyestrogens Journal of Steroid Biochemistry. 33: 589-593. PMID 2811369 DOI: 10.1016/0022-4731(89)90045-9 |
0.471 |
|
| 1989 |
Brueggemeier RW, Katlic NE, Palmer CW, Stevens JM. Catechol estrogen formation in MCF-7 cell culture and effects of bromoestrogen inhibitors Molecular and Cellular Endocrinology. 64: 161-167. PMID 2551756 DOI: 10.1016/0303-7207(89)90142-1 |
0.567 |
|
| 1988 |
Brueggemeier RW, Li PK. Effects of the aromatase inhibitor 7α-(4' -amino)phenylthio-4-androstene-3, 17-dione on 7, 12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats Cancer Research. 48: 6808-6810. PMID 3141048 |
0.313 |
|
| 1987 |
Brueggemeier RW, Katlic NE. Effects of the aromatase inhibitor 7α-(4 '-amino)phenylthio-4-androstene-3,l7- dione in mcf-7 human mammary carcinoma cell culture Cancer Research. 47: 4548-4551. PMID 3621153 |
0.339 |
|
| 1987 |
Snider CE, Brueggemeier RW. Potent enzyme-activated inhibition of aromatase by a 7 alpha-substituted C19 steroid. The Journal of Biological Chemistry. 262: 8685-9. PMID 3597393 |
0.306 |
|
| 1987 |
Brueggemeier RW, Li PK, Snider CE, Darby MV, Katlic NE. 7 alpha-substituted androstenediones as effective in vitro and in vivo inhibitors of aromatase. Steroids. 50: 163-78. PMID 3504058 DOI: 10.1016/0039-128X(83)90069-7 |
0.479 |
|
| 1987 |
Fung YK, Stevens JM, Palmer CW, Brueggemeier RW. Inhibition by bromoestrogens of the effects of estradiol on apomorphine-induced climbing behavior Steroids. 49: 287-294. PMID 3455044 DOI: 10.1016/0039-128X(87)90005-5 |
0.396 |
|
| 1987 |
Li Pk, Chen HH, Katlic NE, Darby MV, Brueggemeier RW. 7α-substituted steroidal aromatase inhibitors in hormone-dependent breast cancer in culture and in vivo [Poster 23] Steroids. 50: 641-642. DOI: 10.1016/0039-128X(87)90064-X |
0.546 |
|
| 1987 |
Brueggemeier R, Li P, Snider C, Katlic N, Darby M. New 7-substituted steroidal aromatase inhibitors: Biochemical and cell culture studies Journal of Steroid Biochemistry. 28: 151. DOI: 10.1016/0022-4731(87)91536-6 |
0.373 |
|
| 1986 |
Brueggemeier RW, Bannan RA. Androgens inhibit the formation of catechol estrogens by estrogen 2-hydroxylase present in rat liver microsomal preparations Journal of Steroid Biochemistry. 25: 351-354. PMID 3022073 DOI: 10.1016/0022-4731(86)90246-3 |
0.448 |
|
| 1986 |
Brueggemeier R, Katlic N, Li P, Snider C, Darby M. Biochemical pharmacology of 7-alpha-substituted aromatase inhibitors in breast cancer cells in culture and Journal of Steroid Biochemistry. 25: 125. DOI: 10.1016/0022-4731(86)90790-9 |
0.508 |
|
| 1985 |
Darby MV, Lovett JA, Brueggemeier RW, Groziak MP, Counsell RE. 7 alpha-substituted derivatives of androstenedione as inhibitors of estrogen biosynthesis. Journal of Medicinal Chemistry. 28: 803-7. PMID 4009603 DOI: 10.1021/Jm00383A019 |
0.609 |
|
| 1985 |
Snider CE, Brueggemeier RW. Covalent modification of aromatase by a radiolabeled irreversible inhibitor. Journal of Steroid Biochemistry. 22: 325-30. PMID 3990283 DOI: 10.1016/0022-4731(85)90434-0 |
0.381 |
|
| 1985 |
DARBY MV, LOVETT JA, BRUEGGEMEIER RW, GROZIAK MP, COUNSELL RE. ChemInform Abstract: 7α-SUBSTITUTED DERIVATIVES OF ANDROSTENEDIONE AS INHIBITORS OF ESTROGEN BIOSYNTHESIS Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198544291 |
0.561 |
|
| 1984 |
Brueggemeier RW, Kimball JG, Kraft F. Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations-II. Inhibition studies Journal of Steroid Biochemistry. 21: 709-716. PMID 6527535 DOI: 10.1016/0022-4731(84)90035-9 |
0.393 |
|
| 1984 |
Brueggemeier RW, Kimball JG, Kraft F. Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations-I. Metabolite formation and irreversible binding to cellular macromolecules Biochemical Pharmacology. 33: 3853-3859. PMID 6508837 DOI: 10.1016/0006-2952(84)90051-0 |
0.36 |
|
| 1983 |
Brueggemeier RW, Kimball JG. Kinetics of inhibition of estrogen 2-hydroxylase by various haloestrogens Steroids. 42: 93-103. PMID 6673180 DOI: 10.1016/S0039-128X(83)90120-4 |
0.379 |
|
| 1983 |
Brueggemeier RW. Inhibition of estrogen 2-hydroxylase Journal of Steroid Biochemistry. 19: 1683-1685. PMID 6645505 DOI: 10.1016/0022-4731(83)90392-8 |
0.488 |
|
| 1982 |
Brueggemeier RW, Snider CE, Kimball JG. A photoaffinity inhibitor of aromatase. Steroids. 40: 679-89. PMID 7187716 DOI: 10.1016/0039-128X(82)90009-5 |
0.363 |
|
| 1982 |
Brueggemeier RW, Snider CE, Counsell RE. Substituted C19 steroid analogs as inhibitors of aromatase. Cancer Research. 42: 3334s-3337s. PMID 7083196 |
0.588 |
|
| 1982 |
Snider CE, Kimball JG, Brueggemeier RW. 63. Irreversible and photoaffinity inhibitors of aromatase Journal of Steroid Biochemistry. 17. DOI: 10.1016/0022-4731(82)90277-1 |
0.335 |
|
| 1978 |
Brueggemeier RW, Floyd EE, Counsell RE. Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis. Journal of Medicinal Chemistry. 21: 1007-11. PMID 722711 DOI: 10.1002/Chin.197908310 |
0.639 |
|
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