| Year |
Citation |
Score |
| 2019 |
Manning T, Al-Abdul-Wahid MS, Manderville RA, Josephy PD, Kung RW, Wetmore SD. Structure of an Unusual Tetracyclic Deoxyguanosine Adduct: Implications for Frameshift Mutagenicity by Ortho‒Cyano Nitroanilines. Chemical Research in Toxicology. PMID 31885260 DOI: 10.1021/Acs.Chemrestox.9B00411 |
0.33 |
|
| 2017 |
Josephy PD, Dhanoa J, Elzawy G, Heney K, Petrie L, Senis C. Structure-activity investigation of the potentiating effect of cyano substitution on nitroaniline mutagenicity in the ames test. Environmental and Molecular Mutagenesis. 59: 114-122. PMID 29178210 DOI: 10.1002/Em.22161 |
0.335 |
|
| 2016 |
Deol R, Josephy PD. Acetylation of aromatic cysteine conjugates by recombinant human N-acetyltransferase 8. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-6. PMID 27180734 DOI: 10.1080/00498254.2016.1178410 |
0.376 |
|
| 2015 |
Josephy PD, Zahid M, Dhanoa J, de Souza GB, Groom H, Lambie M. Potent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes. Environmental and Molecular Mutagenesis. PMID 26394367 DOI: 10.1002/Em.21983 |
0.353 |
|
| 2014 |
Groom H, Lee M, Patil P, Josephy PD. Inhibition of human glutathione transferases by dinitronaphthalene derivatives. Archives of Biochemistry and Biophysics. 555: 71-6. PMID 24929189 DOI: 10.1016/J.Abb.2014.06.002 |
0.318 |
|
| 2011 |
Josephy PD, Pan D, Ianni MD, Mannervik B. Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface. Archives of Biochemistry and Biophysics. 513: 87-93. PMID 21781954 DOI: 10.1016/J.Abb.2011.07.003 |
0.316 |
|
| 2011 |
Sacks PG, Zhao Z, Kosinska W, He Z, Josephy PD, Guttenplan JB. Abstract 3701: Dimethylbenzanthracene (DMBA) and DMBA dihydrodiol mutagenicity in rat epithelial and fibroblast cell lines, and its inhibition by combinations of nutraceuticals Cancer Research. 71: 3701-3701. DOI: 10.1158/1538-7445.Am2011-3701 |
0.378 |
|
| 2010 |
Josephy PD. Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology. Human Genomics and Proteomics : Hgp. 2010: 876940. PMID 20981235 DOI: 10.4061/2010/876940 |
0.301 |
|
| 2009 |
Josephy PD, Kent M, Mannervik B. Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties. Archives of Biochemistry and Biophysics. 490: 24-9. PMID 19664997 DOI: 10.1016/J.Abb.2009.07.025 |
0.335 |
|
| 2009 |
Zenser TV, Lakshmi VM, Schut HA, Zhou HJ, Josephy P. Activation of aminoimidazole carcinogens by nitrosation: mutagenicity and nucleotide adducts. Mutation Research. 673: 109-15. PMID 19449459 DOI: 10.1016/J.Mrgentox.2008.12.007 |
0.386 |
|
| 2007 |
Scott KA, Turesky RJ, Wainman BC, Josephy PD. Hplc/electrospray ionization mass spectrometric analysis of the heterocyclic aromatic amine carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human milk. Chemical Research in Toxicology. 20: 88-94. PMID 17226930 DOI: 10.1021/Tx0601861 |
0.302 |
|
| 2006 |
Josephy PD, Taylor PL, Vervaet G, Mannervik B. Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen. Environmental and Molecular Mutagenesis. 47: 657-65. PMID 16948056 DOI: 10.1002/Em.20252 |
0.372 |
|
| 2005 |
Papp-Szabó E, Josephy PD, Coomber BL. Microenvironmental influences on mutagenesis in mammary epithelial cells. International Journal of Cancer. 116: 679-85. PMID 15849743 DOI: 10.1002/Ijc.21088 |
0.353 |
|
| 2004 |
Zhou H, Josephy PD, Kim D, Guengerich FP. Functional characterization of four allelic variants of human cytochrome P450 1A2. Archives of Biochemistry and Biophysics. 422: 23-30. PMID 14725854 DOI: 10.1016/J.Abb.2003.11.019 |
0.338 |
|
| 2004 |
Summerscales JE, Josephy PD. Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis. Molecular Pharmacology. 65: 220-6. PMID 14722254 DOI: 10.1124/Mol.65.1.220 |
0.371 |
|
| 2003 |
Papp-Szabó E, Douglas GR, Coomber BL, Josephy PD. Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts. Mutation Research. 522: 107-17. PMID 12517416 DOI: 10.1016/S0027-5107(02)00285-3 |
0.42 |
|
| 2002 |
Josephy PD. Genetically-engineered bacteria expressing human enzymes and their use in the study of mutagens and mutagenesis. Toxicology. 181: 255-60. PMID 12505321 DOI: 10.1016/S0300-483X(02)00292-5 |
0.351 |
|
| 2002 |
Josephy PD, Summerscales J, DeBruin LS, Schlaeger C, Ho J. N-hydroxyarylamine O-acetyltransferase-deficient Escherichia coli strains are resistant to the mutagenicity of nitro compounds. Biological Chemistry. 383: 977-82. PMID 12222687 DOI: 10.1515/Bc.2002.104 |
0.756 |
|
| 2002 |
McDiarmid HM, Douglas GR, Coomber BL, Josephy PD. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells. Environmental and Molecular Mutagenesis. 39: 245-53. PMID 11921195 DOI: 10.1002/Em.10059 |
0.72 |
|
| 2002 |
Thompson PA, DeMarini DM, Kadlubar FF, McClure GY, Brooks LR, Green BL, Fares MY, Stone A, Josephy PD, Ambrosone CB. Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cells. Environmental and Molecular Mutagenesis. 39: 134-42. PMID 11921181 DOI: 10.1002/Em.10067 |
0.371 |
|
| 2002 |
DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 110: 119-28. PMID 11834470 DOI: 10.1289/Ehp.02110S1119 |
0.725 |
|
| 2001 |
Puente NW, Josephy PD. Analysis of the lidocaine metabolite 2,6-dimethylaniline in bovine and human milk. Journal of Analytical Toxicology. 25: 711-5. PMID 11765029 DOI: 10.1093/Jat/25.8.711 |
0.321 |
|
| 2001 |
DeBruin LS, Martos PA, Josephy PD. Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. Chemical Research in Toxicology. 14: 1523-8. PMID 11712910 DOI: 10.1021/tx015556u |
0.731 |
|
| 2001 |
McDiarmid HM, Douglas GR, Coomber BL, Josephy PD. Epithelial and fibroblast cell lines cultured from the transgenic BigBlue rat: an in vitro mutagenesis assay. Mutation Research. 497: 39-47. PMID 11525906 DOI: 10.1016/S1383-5718(01)00245-5 |
0.703 |
|
| 2000 |
Josephy PD. The Escherichia coli lacZ reversion mutagenicity assay. Mutation Research. 455: 71-80. PMID 11113468 DOI: 10.1016/S0027-5107(00)00063-4 |
0.325 |
|
| 2000 |
Josephy PD, Bibeau KL, Evans DH. Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2. Environmental and Molecular Mutagenesis. 35: 328-35. PMID 10861951 DOI: 10.1002/1098-2280(2000)35:4<328::Aid-Em7>3.0.Co;2-C |
0.328 |
|
| 1999 |
Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP. Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. Mutation Research. 429: 199-208. PMID 10526205 DOI: 10.1016/S0027-5107(99)00120-7 |
0.343 |
|
| 1999 |
Constable A, Varga N, Josephy PD, Guy P, Turesky RJ. Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures. Mutation Research. 442: 79-87. PMID 10393276 DOI: 10.1016/S1383-5718(99)00066-2 |
0.386 |
|
| 1999 |
DeBruin LS, Pawliszyn JB, Josephy PD. Detection of monocyclic aromatic amines, possible mammary carcinogens, in human milk. Chemical Research in Toxicology. 12: 78-82. PMID 9894021 DOI: 10.1021/tx980168m |
0.743 |
|
| 1998 |
Josephy PD, Coomber BL. The 1996 Veylien Henderson Award of the Society of Toxicology of Canada. Current concepts: neutrophils and the activation of carcinogens in the breast and other organs. Canadian Journal of Physiology and Pharmacology. 76: 693-700. PMID 10030448 DOI: 10.1139/Cjpp-76-7-8-693 |
0.344 |
|
| 1998 |
DeBruin LS, Josephy PD, Pawliszyn JB. Solid-phase microextraction of monocyclic aromatic amines from biological fluids. Analytical Chemistry. 70: 1986-92. PMID 9599591 DOI: 10.1021/ac9709413 |
0.715 |
|
| 1997 |
Josephy PD, Gruz P, Nohmi T. Recent advances in the construction of bacterial genotoxicity assays. Mutation Research. 386: 1-23. PMID 9100853 DOI: 10.1016/S1383-5742(96)00041-5 |
0.381 |
|
| 1996 |
Josephy PD. The role of peroxidase-catalyzed activation of aromatic amines in breast cancer. Mutagenesis. 11: 3-7. PMID 8671708 DOI: 10.1093/Mutage/11.1.3 |
0.357 |
|
| 1995 |
Josephy PD, DeBruin LS, Lord HL, Oak JN, Evans DH, Guo Z, Dong MS, Guengerich FP. Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations. Cancer Research. 55: 799-802. PMID 7850792 |
0.758 |
|
| 1995 |
Wild D, Feser W, Michel S, Lord HL, Josephy PD. Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. Carcinogenesis. 16: 643-8. PMID 7697826 DOI: 10.1093/carcin/16.3.643 |
0.313 |
|
| 1995 |
Marwood TM, Meyer D, Josephy PD. Escherichia coli lacZ strains engineered for detection of frameshift mutations induced by aromatic amines and nitroaromatic compounds. Carcinogenesis. 16: 2037-43. PMID 7554051 DOI: 10.1093/Carcin/16.9.2037 |
0.365 |
|
| 1994 |
Wallace RE, Josephy PD. Mutational spectrum of revertants in the hisD3052 allele of Salmonella typhimurium induced by hydrogen peroxide-activated benzidine. Mutation Research. 311: 9-20. PMID 7526179 DOI: 10.1016/0027-5107(94)90068-X |
0.319 |
|
| 1993 |
Morrison LD, Eling TE, Josephy PD. Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ. Mutation Research. 302: 45-52. PMID 7683106 DOI: 10.1016/0165-7992(93)90089-E |
0.33 |
|
| 1992 |
Grant DM, Josephy PD, Lord HL, Morrison LD. Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines. Cancer Research. 52: 3961-4. PMID 1617672 |
0.328 |
|
| 1992 |
Smith BJ, DeBruin L, Josephy PD, Eling TE. Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4'-(acetylamino)biphenyl. Chemical Research in Toxicology. 5: 431-9. PMID 1504268 |
0.744 |
|
| 1992 |
Thompson DC, Josephy PD, Chu JW, Eling TE. Enhanced mutagenicity of anisidine isomers in bacterial strains containing elevated N-acetyltransferase activity. Mutation Research. 279: 83-9. PMID 1375342 DOI: 10.1016/0165-1218(92)90249-Y |
0.39 |
|
| 1992 |
Smith BJ, DeBruin L, Josephy PD, Eling TE. Mutagenic activation of benzidine requires prior bacterial acetylation and subsequent conversion by prostaglandin H synthase to 4-nitro-4′-(acetylamino)biphenyl Chemical Research in Toxicology. 5: 431-439. |
0.744 |
|
| 1990 |
McGowan-Jordan IJ, Josephy PD. Hydroperoxidase I catalyzes peroxidative activation of 3,3'-dichlorobenzidine to a mutagen in Salmonella typhimurium. Archives of Biochemistry and Biophysics. 282: 352-7. PMID 2241156 DOI: 10.1016/0003-9861(90)90128-L |
0.339 |
|
| 1989 |
Lord HL, Snieckus VA, Josephy PD. Re-evaluation of the effect of ellagic acid on dimethylnitrosamine mutagenicity. Mutagenesis. 4: 453-5. PMID 2695758 DOI: 10.1093/Mutage/4.6.453 |
0.333 |
|
| 1989 |
DeBruin LS, Josephy PD. Dichlorobenzidine-DNA binding catalyzed by peroxidative activation in Salmonella typhimurium. Archives of Biochemistry and Biophysics. 269: 25-31. PMID 2644894 DOI: 10.1016/0003-9861(89)90083-0 |
0.727 |
|
| 1987 |
Light HC, Hubert JJ, Josephy PD, Mattano SS, Weber WW. Benzidine activation in the Ames test: roles of hepatic N-acetyltransferase and other cytosolic and microsomal factors. Carcinogenesis. 8: 139-43. PMID 3542272 DOI: 10.1093/Carcin/8.1.139 |
0.353 |
|
| 1987 |
Savard S, Josephy PD. Synthesis and mutagenicity of 3-halogenated and 3,3',5,5'-tetrahalogenated benzidines. Mutagenesis. 2: 97-9. PMID 3331708 DOI: 10.1093/Mutage/2.2.97 |
0.321 |
|
| 1987 |
Josephy PD, Williams LL. Unambiguous synthesis of asymmetrically substituted chlorinated benzidines, and a study of their mutagenicity in the Ames test: potent activity of 3,5,3'-trichlorobenzidine. Mutagenesis. 2: 225-8. PMID 3325748 DOI: 10.1093/Mutage/2.3.225 |
0.332 |
|
| 1986 |
Carter MH, Josephy PD. Mutagenicity of thionitrites in the Ames test. The biological activity of thiyl free radicals. Biochemical Pharmacology. 35: 3847-51. PMID 3535804 DOI: 10.1016/0006-2952(86)90674-X |
0.333 |
|
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