Lawrence P. McIntosh - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Molecular Biology, Biochemistry

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Sheng-Huei Lin C, Chan ACK, Vermeulen J, Brockerman J, Soni AS, Tanner ME, Gaynor EC, McIntosh LP, Simorre JP, Murphy MEP. Peptidoglycan binding by a pocket on the accessory NTF2-domain of Pgp2 directs helical cell shape of Campylobacter jejuni. The Journal of Biological Chemistry. 100528. PMID 33711341 DOI: 10.1016/j.jbc.2021.100528  0.384
2021 Gerak CAN, Cho SY, Kolesnikov M, Okon M, Murphy MEP, Sessions RB, Roberge M, McIntosh LP. Biophysical characterization of the ETV6 PNT domain polymerization interfaces. The Journal of Biological Chemistry. 100284. PMID 33450226 DOI: 10.1016/j.jbc.2021.100284  0.361
2021 Perez-Borrajero C, Heinkel F, Gsponer J, McIntosh LP. Conformational Plasticity and DNA-Binding Specificity of the Eukaryotic Transcription Factor Pax5. Biochemistry. 60: 104-117. PMID 33398994 DOI: 10.1021/acs.biochem.0c00737  0.31
2020 Gerak CAN, Zhang SM, Balgi AD, Sadowski IJ, Sessions RB, McIntosh LP, Roberge M. A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization. Slas Discovery : Advancing Life Sciences R & D. 2472555220979599. PMID 33345679 DOI: 10.1177/2472555220979599  0.35
2020 Majewski DD, Okon M, Heinkel F, Robb CS, Vuckovic M, McIntosh LP, Strynadka NCJ. Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods. Structure (London, England : 1993). PMID 32877645 DOI: 10.1016/J.Str.2020.08.006  0.334
2020 Terrado M, Okon M, McIntosh LP, Plettner E. Ligand- and pH-Induced Structural Transition of Gypsy Moth Pheromone-Binding Protein 1 (LdisPBP1). Biochemistry. PMID 32877603 DOI: 10.1021/Acs.Biochem.0C00592  0.409
2019 Heinkel F, Abraham L, Ko M, Chao J, Bach H, Hui LT, Li H, Zhu M, Ling YM, Rogalski JC, Scurll J, Bui JM, Mayor T, Gold MR, Chou KC, ... ... McIntosh LP, et al. Phase separation and clustering of an ABC transporter in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31366629 DOI: 10.1073/Pnas.1820683116  0.309
2018 Perez-Borrajero C, Lin CS, Okon M, Scheu K, Graves BJ, Murphy MEP, McIntosh LP. The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. Journal of Molecular Biology. PMID 30597162 DOI: 10.2210/Pdb6Dat/Pdb  0.471
2018 Brockerman JA, Okon M, Withers SG, McIntosh LP. The pK values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme. Protein Science : a Publication of the Protein Society. PMID 30537432 DOI: 10.1002/Pro.3562  0.358
2018 Bergeron JRC, Brockerman JA, Vuckovic M, Deng W, Okon M, Finlay BB, McIntosh LP, Strynadka NCJ. Characterization of the two conformations adopted by the T3SS inner-membrane protein PrgK. Protein Science : a Publication of the Protein Society. PMID 30095200 DOI: 10.1002/Pro.3447  0.427
2018 Koetzler MP, Robinson K, Chen HM, Okon M, McIntosh LP, Withers SG. Modulating the nucleophile of a glycoside hydrolase through site-specific incorporation of fluoroglutamic acids. Journal of the American Chemical Society. PMID 29894173 DOI: 10.1021/Jacs.8B04235  0.317
2018 Heinkel F, Shen L, Richard-Greenblatt M, Okon M, Bui JM, Gee CL, Gay LM, Alber T, Av-Gay Y, Gsponer J, McIntosh LP. Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacteriumtuberculosis ABC Transporter Rv1747. Structure (London, England : 1993). PMID 29861345 DOI: 10.1016/J.Str.2018.04.018  0.454
2018 Gardill BR, Rivera-Acevedo RE, Tung CC, Okon M, McIntosh LP, Van Petegem F. The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations. Scientific Reports. 8: 4483. PMID 29540853 DOI: 10.1038/S41598-018-22713-Y  0.311
2018 Heinkel F, Okon M, Gsponer J, McIntosh LP. NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb6Cah/Pdb  0.349
2018 Heinkel F, Shen L, Richard-Greenblatt M, Av-Gay Y, Gsponer J, McIntosh L. Backbone 1H, 13C, and 15N Chemical Shift Assignments for FHA-1 domain of Rv1747 from Mycobacterium tuberculosis Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27394  0.375
2017 Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves BJ. ETV4 and AP1 transcription factors form multivalent interactions with three sites on the MED25 activator-interacting domain. Journal of Molecular Biology. PMID 28728983 DOI: 10.1016/J.Jmb.2017.06.024  0.408
2017 Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, ... ... McIntosh LP, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. PMID 28465491 DOI: 10.18632/Oncotarget.17124  0.343
2017 Currie SL, Lau DK, Doane JJ, Whitby FG, Okon M, McIntosh LP, Graves BJ. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Research. PMID 28161714 DOI: 10.1093/Nar/Gkx068  0.49
2017 Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, ... ... McIntosh LP, et al. Abstract 130: Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer Cancer Research. 77: 130-130. DOI: 10.1158/1538-7445.Am2017-130  0.351
2016 Desjardins G, Okon M, Graves BJ, McIntosh LP. Conformational dynamics and the binding of specific and non-specific DNA by the autoinhibited transcription factor Ets-1. Biochemistry. PMID 27362745 DOI: 10.1021/Acs.Biochem.6B00460  0.423
2016 Perez-Borrajero C, Okon M, McIntosh LP. Structural and dynamics studies of Pax5 reveal asymmetry in stability and DNA binding by the Paired domain. Journal of Molecular Biology. PMID 27067111 DOI: 10.1016/J.Jmb.2016.04.004  0.396
2016 De S, Okon M, Graves BJ, McIntosh LP. Autoinhibition of ETV6 DNA-binding is established by the stability of its inhibitory helix. Journal of Molecular Biology. PMID 26920109 DOI: 10.1016/J.Jmb.2016.02.020  0.47
2015 Fitch CA, Platzer G, Okon M, Garcia-Moreno BE, McIntosh LP. Arginine: Its pKa value revisited. Protein Science : a Publication of the Protein Society. 24: 752-61. PMID 25808204 DOI: 10.1002/Pro.2647  0.331
2015 Bergeron JR, Worrall LJ, De S, Sgourakis NG, Cheung AH, Lameignere E, Okon M, Wasney GA, Baker D, McIntosh LP, Strynadka NC. The modular structure of the inner-membrane ring component PrgK facilitates assembly of the type III secretion system basal body. Structure (London, England : 1993). 23: 161-72. PMID 25533490 DOI: 10.1016/J.Str.2014.10.021  0.366
2015 Butler MS, Hsing M, Moniri MR, Lau D, Yen P, Kim A, Lien S, Mroczek M, Ghaidi F, LeBlanc E, McIntosh L, Cox M, Cherkasov A, Rennie PS. Abstract 1648: Targeting ETS factor ETV4 as a novel therapeutic for the management of breast and prostate cancer Cancer Research. 75: 1648-1648. DOI: 10.1158/1538-7445.Am2015-1648  0.301
2014 Platzer G, Okon M, McIntosh LP. pH-dependent random coil (1)H, (13)C, and (15)N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements. Journal of Biomolecular Nmr. 60: 109-29. PMID 25239571 DOI: 10.1007/S10858-014-9862-Y  0.403
2014 Zhang XL, De S, McIntosh LP, Paetzel M. Structural characterization of the C3 domain of cardiac myosin binding protein C and its hypertrophic cardiomyopathy-related R502W mutant. Biochemistry. 53: 5332-42. PMID 25058872 DOI: 10.1021/Bi500784G  0.392
2014 Desjardins G, Meeker CA, Bhachech N, Currie SL, Okon M, Graves BJ, McIntosh LP. Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 111: 11019-24. PMID 25024220 DOI: 10.1073/Pnas.1401891111  0.464
2014 De S, Chan AC, Coyne HJ, Bhachech N, Hermsdorf U, Okon M, Murphy ME, Graves BJ, McIntosh LP. Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6. Journal of Molecular Biology. 426: 1390-406. PMID 24333486 DOI: 10.1016/J.Jmb.2013.11.031  0.441
2014 Brockerman JA, Okon M, McIntosh LP. Detection and characterization of serine and threonine hydroxyl protons in Bacillus circulans xylanase by NMR spectroscopy. Journal of Biomolecular Nmr. 58: 17-25. PMID 24306180 DOI: 10.1007/S10858-013-9799-6  0.385
2013 Kukic P, Farrell D, McIntosh LP, García-Moreno E B, Jensen KS, Toleikis Z, Teilum K, Nielsen JE. Protein dielectric constants determined from NMR chemical shift perturbations. Journal of the American Chemical Society. 135: 16968-76. PMID 24124752 DOI: 10.1021/Ja406995J  0.324
2013 Cetinbas N, Huang-Hobbs H, Tognon C, Leprivier G, An J, McKinney S, Bowden M, Chow C, Gleave M, McIntosh LP, Sorensen PH. Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation. The Journal of Biological Chemistry. 288: 27940-50. PMID 23798677 DOI: 10.1074/Jbc.M113.475301  0.416
2013 Ludwiczek ML, D'Angelo I, Yalloway GN, Brockerman JA, Okon M, Nielsen JE, Strynadka NC, Withers SG, McIntosh LP. Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase. Biochemistry. 52: 3138-56. PMID 23578322 DOI: 10.1021/Bi400034M  0.338
2013 Chan PH, Cheung AH, Okon M, Chen HM, Withers SG, McIntosh LP. Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy. Biochemistry. 52: 320-32. PMID 23259770 DOI: 10.1021/Bi301317D  0.378
2013 Stevens CM, Okon M, McIntosh LP, Paetzel M. ¹H, ¹³C and ¹⁵N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD. Biomolecular Nmr Assignments. 7: 193-7. PMID 22766963 DOI: 10.1007/S12104-012-9408-8  0.383
2013 De S, McIntosh L, Chan A, Coyne H, Okon M, Graves B, Murphy M. Structure of uninhibited ETV6 ETS domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Md5/Pdb  0.428
2012 Chan PH, Weissbach S, Okon M, Withers SG, McIntosh LP. Nuclear magnetic resonance spectral assignments of α-1,4-galactosyltransferase LgtC from Neisseria meningitidis: substrate binding and multiple conformational states. Biochemistry. 51: 8278-92. PMID 22992161 DOI: 10.1021/Bi3010279  0.393
2012 Lau DK, Okon M, McIntosh LP. The PNT domain from Drosophila pointed-P2 contains a dynamic N-terminal helix preceded by a disordered phosphoacceptor sequence. Protein Science : a Publication of the Protein Society. 21: 1716-25. PMID 22936607 DOI: 10.1002/Pro.2151  0.467
2012 Prehna G, Li Y, Stoynov N, Okon M, Vuckovic M, McIntosh LP, Foster LJ, Finlay BB, Strynadka NC. The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. The Journal of Biological Chemistry. 287: 32324-37. PMID 22810234 DOI: 10.1074/Jbc.M112.357210  0.436
2012 Prehna G, Zhang G, Gong X, Duszyk M, Okon M, McIntosh LP, Weiner JH, Strynadka NC. A protein export pathway involving Escherichia coli porins. Structure (London, England : 1993). 20: 1154-66. PMID 22658749 DOI: 10.1016/J.Str.2012.04.014  0.377
2012 Ming-Lum A, Shojania S, So E, McCarrell E, Shaw E, Vu D, Wang I, McIntosh LP, Mui AL. A pleckstrin homology-related domain in SHIP1 mediates membrane localization during Fcγ receptor-induced phagocytosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3163-77. PMID 22651931 DOI: 10.1096/Fj.11-201475  0.363
2012 Coyne HJ, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP. Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain. Journal of Molecular Biology. 421: 67-84. PMID 22584210 DOI: 10.1016/J.Jmb.2012.05.010  0.497
2012 De S, McIntosh LP. Putting a stop to L,D-transpeptidases. Structure (London, England : 1993). 20: 753-4. PMID 22579243 DOI: 10.1016/J.Str.2012.04.005  0.321
2012 Giovinazzi S, Lindsay CR, Morozov VM, Escobar-Cabrera E, Summers MK, Han HS, McIntosh LP, Ishov AM. Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene. 31: 13-26. PMID 21643015 DOI: 10.1038/Onc.2011.211  0.355
2012 Muhandiram DR, Johnson PE, Yang D, Zhang O, McIntosh LP, Kay LE. Specific (15)N, NH correlations for residues in(15) N, (13)C and fractionally deuterated proteins that immediately follow methyl-containing amino acids. Journal of Biomolecular Nmr. 10: 283-8. PMID 20700832 DOI: 10.1023/A:1018301818803  0.357
2012 McIntosh LP, Brun E, Kay LE. Stereospecific assignment of the NH2 resonances from the primary amides of asparagine and glutamine side chains in isotopically labeled proteins. Journal of Biomolecular Nmr. 9: 306-12. PMID 20680662 DOI: 10.1023/A:1018635110491  0.37
2012 Prehna G, Li Y, Stoynov N, Okon M, Vukovic M, McIntosh L, Foster L, Finlay BB, Strynadka N. ZirS C-terminal Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lv4/Pdb  0.391
2011 McIntosh LP, Naito D, Baturin SJ, Okon M, Joshi MD, Nielsen JE. Dissecting electrostatic interactions in Bacillus circulans xylanase through NMR-monitored pH titrations. Journal of Biomolecular Nmr. 51: 5-19. PMID 21947911 DOI: 10.1007/S10858-011-9537-X  0.355
2011 Baturin SJ, Okon M, McIntosh LP. Structure, dynamics, and ionization equilibria of the tyrosine residues in Bacillus circulans xylanase. Journal of Biomolecular Nmr. 51: 379-94. PMID 21912982 DOI: 10.1007/S10858-011-9564-7  0.387
2011 Hollenhorst PC, McIntosh LP, Graves BJ. Genomic and biochemical insights into the specificity of ETS transcription factors. Annual Review of Biochemistry. 80: 437-71. PMID 21548782 DOI: 10.1146/Annurev.Biochem.79.081507.103945  0.449
2011 Escobar-Cabrera E, Okon M, Lau DK, Dart CF, Bonvin AM, McIntosh LP. Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX. The Journal of Biological Chemistry. 286: 19816-29. PMID 21383010 DOI: 10.1074/Jbc.M111.231647  0.435
2011 Webb H, Tynan-Connolly BM, Lee GM, Farrell D, O'Meara F, Søndergaard CR, Teilum K, Hewage C, McIntosh LP, Nielsen JE. Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculations. Proteins. 79: 685-702. PMID 21287606 DOI: 10.1002/Prot.22886  0.381
2011 Kim KH, Kang HS, Okon M, Escobar-Cabrera E, McIntosh LP, Paetzel M. Structural characterization of Escherichia coli BamE, a lipoprotein component of the β-barrel assembly machinery complex. Biochemistry. 50: 1081-90. PMID 21207987 DOI: 10.1021/Bi101659U  0.41
2011 Lee G, Donaldson L, Pufall M, Kang H, Gentile L, Pot I, Graves B, McIntosh L. Backbone and Sidechain 1H, 13C, and 15N Chemical Shift Assignments and Backbone 15N Relaxation Parameters for Murine Ets-1 deltaN301 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5991  0.339
2010 Escobar-Cabrera E, Lau DK, Giovinazzi S, Ishov AM, McIntosh LP. Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C. Structure (London, England : 1993). 18: 1642-53. PMID 21134643 DOI: 10.1016/J.Str.2010.09.016  0.461
2010 Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proceedings of the National Academy of Sciences of the United States of America. 107: 10026-31. PMID 20534573 DOI: 10.1073/Pnas.0915137107  0.459
2010 Green SM, Coyne HJ, McIntosh LP, Graves BJ. DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. The Journal of Biological Chemistry. 285: 18496-504. PMID 20400516 DOI: 10.1074/Jbc.M109.096958  0.463
2010 Reitinger S, Yu Y, Wicki J, Ludwiczek M, D'Angelo I, Baturin S, Okon M, Strynadka NC, Lutz S, Withers SG, McIntosh LP. Circular permutation of Bacillus circulans xylanase: a kinetic and structural study. Biochemistry. 49: 2464-74. PMID 20163191 DOI: 10.1021/Bi100036F  0.392
2010 Farrell D, Miranda ES, Webb H, Georgi N, Crowley PB, McIntosh LP, Nielsen JE. Titration DB: Storage and analysis of NMR-monitored protein pH titration curves Proteins: Structure, Function and Bioinformatics. 78: 843-857. PMID 19899070 DOI: 10.1002/Prot.22611  0.372
2009 Chan PH, Lairson LL, Lee HJ, Wakarchuk WW, Strynadka NC, Withers SG, McIntosh LP. NMR spectroscopic characterization of the sialyltransferase CstII from Campylobacter jejuni: histidine 188 is the general base. Biochemistry. 48: 11220-30. PMID 19824695 DOI: 10.1021/Bi901606N  0.411
2009 McIntosh LP, Kang HS, Okon M, Nelson ML, Graves BJ, Brutscher B. Detection and assignment of phosphoserine and phosphothreonine residues by (13)C- (31)P spin-echo difference NMR spectroscopy. Journal of Biomolecular Nmr. 43: 31-7. PMID 19002654 DOI: 10.1007/S10858-008-9287-6  0.354
2009 Kang H, Lee G, Nelson M, Graves B, Blaszczak A, McIntosh L. NMR-derived structure of residues 29-138 of murine Ets-1, containing the PNT domain, along with phosphorylated Thr38 and Ser41 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16426  0.463
2008 Okon M, Moraes TF, Lario PI, Creagh AL, Haynes CA, Strynadka NC, McIntosh LP. Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (London, England : 1993). 16: 1544-54. PMID 18940609 DOI: 10.1016/J.Str.2008.08.006  0.402
2008 Wilke MS, Heller M, Creagh AL, Haynes CA, McIntosh LP, Poole K, Strynadka NC. The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR. Proceedings of the National Academy of Sciences of the United States of America. 105: 14832-7. PMID 18812515 DOI: 10.1073/Pnas.0805489105  0.429
2008 Lee GM, Pufall MA, Meeker CA, Kang HS, Graves BJ, McIntosh LP. The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region. Journal of Molecular Biology. 382: 1014-30. PMID 18692067 DOI: 10.1016/J.Jmb.2008.07.064  0.448
2008 Feldman AR, Shapova YA, Wu SS, Oliver DC, Heller M, McIntosh LP, Scott JK, Paetzel M. Phage display and crystallographic analysis reveals potential substrate/binding site interactions in the protein secretion chaperone CsaA from Agrobacterium tumefaciens. Journal of Molecular Biology. 379: 457-70. PMID 18462752 DOI: 10.1016/J.Jmb.2008.03.048  0.395
2008 Kang HS, Nelson ML, Mackereth CD, Schärpf M, Graves BJ, McIntosh LP. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. Journal of Molecular Biology. 377: 636-46. PMID 18295234 DOI: 10.1016/J.Jmb.2008.01.054  0.717
2008 Søndergaard CR, McIntosh LP, Pollastri G, Nielsen JE. Determination of electrostatic interaction energies and protonation state populations in enzyme active sites. Journal of Molecular Biology. 376: 269-87. PMID 18155242 DOI: 10.1016/J.Jmb.2007.09.070  0.378
2007 Ludwiczek ML, Heller M, Kantner T, McIntosh LP. A secondary xylan-binding site enhances the catalytic activity of a single-domain family 11 glycoside hydrolase. Journal of Molecular Biology. 373: 337-54. PMID 17822716 DOI: 10.1016/J.Jmb.2007.07.057  0.434
2007 Lakowski TM, Lee GM, Lelj-Garolla B, Okon M, Reid RE, McIntosh LP. Peptide binding by a fragment of calmodulin composed of EF-hands 2 and 3. Biochemistry. 46: 8525-36. PMID 17595060 DOI: 10.1021/Bi700265J  0.404
2007 Schubert M, Poon DK, Wicki J, Tarling CA, Kwan EM, Nielsen JE, Withers SG, McIntosh LP. Probing electrostatic interactions along the reaction pathway of a glycoside hydrolase: histidine characterization by NMR spectroscopy. Biochemistry. 46: 7383-95. PMID 17547373 DOI: 10.1021/Bi700249M  0.641
2007 Lakowski TM, Lee GM, Okon M, Reid RE, McIntosh LP. Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3. Protein Science : a Publication of the Protein Society. 16: 1119-32. PMID 17473011 DOI: 10.1110/Ps.072777107  0.396
2007 Poon DK, Ludwiczek ML, Schubert M, Kwan EM, Withers SG, McIntosh LP. NMR spectroscopic characterization of a beta-(1,4)-glycosidase along its reaction pathway: stabilization upon formation of the glycosyl-enzyme intermediate. Biochemistry. 46: 1759-70. PMID 17253772 DOI: 10.1021/Bi061694C  0.633
2007 Poon DK, Withers SG, McIntosh LP. Direct demonstration of the flexibility of the glycosylated proline-threonine linker in the Cellulomonas fimi Xylanase Cex through NMR spectroscopic analysis. The Journal of Biological Chemistry. 282: 2091-100. PMID 17121820 DOI: 10.1074/Jbc.M609670200  0.505
2007 Lakowski T, Lee G, Reid R, McIntosh L. The structure and function of a novel two-site calcium-binding fragment of calmodulin Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.14288/1.0092841  0.317
2006 Poon DK, Schubert M, Au J, Okon M, Withers SG, McIntosh LP. Unambiguous determination of the ionization state of a glycoside hydrolase active site lysine by 1H-15N heteronuclear correlation spectroscopy. Journal of the American Chemical Society. 128: 15388-9. PMID 17132001 DOI: 10.1021/Ja065766Z  0.636
2006 Kim YW, Fox DT, Hekmat O, Kantner T, McIntosh LP, Warren RA, Withers SG. Glycosynthase-based synthesis of xylo-oligosaccharides using an engineered retaining xylanase from Cellulomonas fimi. Organic & Biomolecular Chemistry. 4: 2025-32. PMID 16688347 DOI: 10.1039/B601667G  0.33
2006 Macauley MS, Errington WJ, Schärpf M, Mackereth CD, Blaszczak AG, Graves BJ, McIntosh LP. Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. The Journal of Biological Chemistry. 281: 4164-72. PMID 16319071 DOI: 10.1074/Jbc.M510488200  0.722
2005 Escobar-Cabrera E, Venkatesan M, Desautels M, Hemmingsen SM, McIntosh LP. Dissecting the domain structure of Cdc4p, a myosin essential light chain involved in Schizosaccharomyces pombe cytokinesis. Biochemistry. 44: 12136-48. PMID 16142912 DOI: 10.1021/Bi050641C  0.495
2005 Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science (New York, N.Y.). 309: 142-5. PMID 15994560 DOI: 10.1126/Science.1111915  0.396
2005 Okon M, Pfuetzner RA, Vuckovic M, Little JW, Strynadka NC, McIntosh LP. Backbone chemical shift assignments of the LexA catalytic domain in its active conformation. Journal of Biomolecular Nmr. 31: 371-2. PMID 15929009 DOI: 10.1007/S10858-005-0944-8  0.444
2005 Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP. The structural and dynamic basis of Ets-1 DNA binding autoinhibition. The Journal of Biological Chemistry. 280: 7088-99. PMID 15591056 DOI: 10.1074/Jbc.M410722200  0.499
2004 Macauley MS, Errington WJ, Okon M, Schärpf M, Mackereth CD, Schulman BA, McIntosh LP. Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. The Journal of Biological Chemistry. 279: 49131-7. PMID 15355965 DOI: 10.1074/Jbc.M408705200  0.716
2004 Mackereth CD, Schärpf M, Gentile LN, MacIntosh SE, Slupsky CM, McIntosh LP. Diversity in structure and function of the Ets family PNT domains. Journal of Molecular Biology. 342: 1249-64. PMID 15351649 DOI: 10.1016/J.Jmb.2004.07.094  0.711
2004 Schubert M, Edge RE, Lario P, Cook MA, Strynadka NC, Mackie GA, McIntosh LP. Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces. Journal of Molecular Biology. 341: 37-54. PMID 15312761 DOI: 10.1016/J.Jmb.2004.05.061  0.69
2004 Tognon CE, Mackereth CD, Somasiri AM, McIntosh LP, Sorensen PH. Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Molecular and Cellular Biology. 24: 4636-50. PMID 15143160 DOI: 10.1128/Mcb.24.11.4636-4650.2004  0.689
2004 Erbel PJ, Seidel R, Macintosh SE, Gentile LN, Amor JC, Kahn RA, Prestegard JH, McIntosh LP, Gardner KH. Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations. Journal of Biomolecular Nmr. 29: 199-204. PMID 15014233 DOI: 10.1023/B:Jnmr.0000019252.65073.24  0.379
2004 Macauley M, Errington W, Okon M, Scharpf M, Mackereth C, Schulman B, McIntosh L. Mainchain proton, carbon and nitrogen chemical shifts for the C-domain of human RanGAP1 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6305  0.651
2002 Mackereth CD, Schärpf M, Gentile LN, McIntosh LP. Chemical shift and secondary structure conservation of the PNT/SAM domains from the ets family of transcription factors. Journal of Biomolecular Nmr. 24: 71-2. PMID 12449421 DOI: 10.1023/A:1020617426325  0.698
2002 Nagulapalli S, Goheer A, Pitt L, McIntosh LP, Atchison ML. Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts. Molecular and Cellular Biology. 22: 7337-50. PMID 12242308 DOI: 10.1128/Mcb.22.20.7337-7350.2002  0.376
2002 Ramachander R, Kim CA, Phillips ML, Mackereth CD, Thanos CD, McIntosh LP, Bowie JU. Oligomerization-dependent association of the SAM domains from Schizosaccharomyces pombe Byr2 and Ste4 Journal of Biological Chemistry. 277: 39585-39593. PMID 12171939 DOI: 10.1074/Jbc.M207273200  0.715
2002 Schärpf M, Connelly GP, Lee GM, Boraston AB, Warren RA, McIntosh LP. Site-specific characterization of the association of xylooligosaccharides with the CBM13 lectin-like xylan binding domain from Streptomyces lividans xylanase 10A by NMR spectroscopy. Biochemistry. 41: 4255-63. PMID 11914071 DOI: 10.1021/Bi015866B  0.422
2002 Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, ... ... McIntosh LP, et al. An NMR approach to structural proteomics. Proceedings of the National Academy of Sciences of the United States of America. 99: 1825-30. PMID 11854485 DOI: 10.1073/Pnas.042684599  0.361
2002 Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. The solution structure and interactions of CheW from Thermotoga maritima. Nature Structural Biology. 9: 121-5. PMID 11799399 DOI: 10.1038/Nsb753  0.421
2002 Wang H, McIntosh LP, Graves BJ. Inhibitory module of Ets-1 allosterically regulates DNA binding through a dipole-facilitated phosphate contact. The Journal of Biological Chemistry. 277: 2225-33. PMID 11689571 DOI: 10.1074/Jbc.M109430200  0.452
2001 Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP. NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum [1] Journal of Biomolecular Nmr. 21: 63-66. PMID 11693569 DOI: 10.2210/Pdb1Iio/Pdb  0.302
2001 Joshi MD, Sidhu G, Nielsen JE, Brayer GD, Withers SG, McIntosh LP. Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase Biochemistry. 40: 10115-10139. PMID 11513590 DOI: 10.2210/Pdb1Hv0/Pdb  0.379
2001 Slupsky CM, Desautels M, Huebert T, Zhao R, Hemmingsen SM, McIntosh LP. Structure of Cdc4p, a Contractile Ring Protein Essential for Cytokinesis in Schizosaccharomyces pombe Journal of Biological Chemistry. 276: 5943-5951. PMID 11087750 DOI: 10.1074/Jbc.M008716200  0.441
2001 Desautels M, Den Haese JP, Slupsky CM, McIntosh LP, Hemmingsen SM. Cdc4p, a Contractile Ring Protein Essential for Cytokinesis in Schizosaccharomyces pombe, Interacts with a Phosphatidylinositol 4-Kinase Journal of Biological Chemistry. 276: 5932-5942. PMID 11087749 DOI: 10.1074/Jbc.M008715200  0.408
2000 Christendat D, Yee A, Dharamsi A, Kluger Y, Savchenko A, Cort JR, Booth V, Mackereth CD, Saridakis V, Ekiel I, Kozlov G, Maxwell KL, Wu N, McIntosh LP, Gehring K, et al. Structural proteomics of an archaeon. Nature Structural Biology. 7: 903-9. PMID 11017201 DOI: 10.1038/82823  0.642
2000 Kormos J, Johnson PE, Brun E, Tomme P, McIntosh LP, Haynes CA, Kilburn DG. Binding site analysis of cellulose binding domain CBD(N1) from endoglucanse C of Cellulomonas fimi by site-directed mutagenesis. Biochemistry. 39: 8844-52. PMID 10913296 DOI: 10.1021/Bi000607S  0.429
2000 Joshi MD, Sidhu G, Pot I, Brayer GD, Withers SG, McIntosh LP. Hydrogen bonding and catalysis: A novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase Journal of Molecular Biology. 299: 255-279. PMID 10860737 DOI: 10.1006/Jmbi.2000.3722  0.352
2000 Mackereth CD, Arrowsmith CH, Edwards AM, McIntosh LP. Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proceedings of the National Academy of Sciences of the United States of America. 97: 6316-21. PMID 10841539 DOI: 10.1073/Pnas.97.12.6316  0.671
2000 Connelly GP, Withers SG, McIntosh LP. Analysis of the dynamic properties of Bacillus circulans xylanase upon formation of a covalent glycosyl-enzyme intermediate Protein Science. 9: 512-524. PMID 10752613 DOI: 10.1110/Ps.9.3.512  0.359
2000 Brun E, Johnson PE, Creagh AL, Tomme P, Webster P, Haynes CA, McIntosh LP. Structure and binding specificity of the second N-terminal cellulose-binding domain from Cellulomonas fimi endoglucanase C. Biochemistry. 39: 2445-58. PMID 10704194 DOI: 10.1021/bi992079u  0.321
1999 Sidhu G, Withers SG, Nguyen NT, McIntosh LP, Ziser L, Brayer GD. Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase Biochemistry. 38: 5346-5354. PMID 10220321 DOI: 10.1021/Bi982946F  0.373
1999 Johnson PE, Brun E, MacKenzie LF, Withers SG, McIntosh LP. The cellulose-binding domains from cellulomonas fimi β-1,4-glucanase CenC bind nitroxide spin-labeled cellooligosaccharides in multiple orientations Journal of Molecular Biology. 287: 609-625. PMID 10092463 DOI: 10.1006/Jmbi.1999.2627  0.393
1999 Wheat W, Fitzsimmons D, Lennox H, Krautkramer SR, Gentile LN, McIntosh LP, Hagman J. The highly conserved β-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes Molecular and Cellular Biology. 19: 2231-2241. PMID 10022910 DOI: 10.1128/Mcb.19.3.2231  0.48
1998 Slupsky CM, Gentile LN, McIntosh LP. Assigning the NMR spectra of aromatic amino acids in proteins: Analysis of two Ets pointed domains Biochemistry and Cell Biology. 76: 379-390. PMID 9923707 DOI: 10.1139/Bcb-76-2-3-379  0.427
1998 Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, Mcintosh LP. Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site Proceedings of the National Academy of Sciences of the United States of America. 95: 12129-12134. PMID 9770451 DOI: 10.1073/Pnas.95.21.12129  0.711
1998 Creagh AL, Koska J, Johnson PE, Tomme P, Joshi MD, McIntosh LP, Kilburn DG, Haynes CA. Stability and oligosaccharide binding of the N1 cellulose-binding domain of Cellulomonas fimi endoglucanase CenC. Biochemistry. 37: 3529-37. PMID 9521674 DOI: 10.1021/Bi971983O  0.478
1998 Connelly GP, McIntosh LP. Characterization of a buried neutral histidine in Bacillus circulans xylanase: Internal dynamics and interaction with a bound water molecule Biochemistry. 37: 1810-1818. PMID 9485306 DOI: 10.1021/Bi972085V  0.324
1997 Joshi MD, Hedberg A, McIntosh LP. Complete measurement of the pK(a) values of the carboxyl and imidazole groups in Bacillus circulans xylanase Protein Science. 6: 2667-2670. PMID 9416621 DOI: 10.1002/Pro.5560061224  0.345
1997 Feher VA, Zapf JW, Hoch JA, Whiteley JM, McIntosh LP, Rance M, Skelton NJ, Dahlquist FW, Cavanagh J. High-resolution NMR structure and backbone dynamics of the Bacillus subtilis response regulator, Spo0F: implications for phosphorylation and molecular recognition. Biochemistry. 36: 10015-25. PMID 9254596 DOI: 10.1021/Bi970816L  0.453
1997 McIntosh LP, Brun E, Kay LE. Stereospecific assignment of the NH2 resonances from the primary amides of asparagine and glutamine side chains in isotopically labeled proteins Journal of Biomolecular Nmr. 9: 306-312.  0.309
1996 Tomme P, Gilkes NR, Guarna MM, Haynes CA, Hasenwinkle D, Jervis E, Johnson P, McIntosh L, Warren RA, Kilburn DG. Cellulose-binding domains. Versatile affinity tags for inexpensive large-scale purification, concentration, and immobilization of fusion proteins. Annals of the New York Academy of Sciences. 799: 418-24. PMID 8958104 DOI: 10.1111/J.1749-6632.1996.Tb33235.X  0.393
1996 Graves BJ, Gillespie ME, McIntosh LP. DNA binding by the ETS domain Nature. 384: 322. PMID 8934514 DOI: 10.1038/384322a0  0.3
1996 Plesniak LA, Connelly GP, Wakarchuk WW, Mcintosh LP. Characterization of a buried neutral histidine residue in Bacillus circulans xylanase: NMR assignments, pH titration, and hydrogen exchange Protein Science. 5: 2319-2328. PMID 8931150 DOI: 10.1002/Pro.5560051118  0.381
1996 Bray MR, Johnson PE, Gilkes NR, McIntosh LP, Kilburn DG, Warren RA. Probing the role of tryptophan residues in a cellulose-binding domain by chemical modification. Protein Science : a Publication of the Protein Society. 5: 2311-8. PMID 8931149 DOI: 10.1002/Pro.5560051117  0.445
1996 Johnson PE, Joshi MD, Tomme P, Kilburn DG, McIntosh LP. Structure of the N-terminal cellulose-binding domain of Cellulomonas fimi CenC determined by nuclear magnetic resonance spectroscopy. Biochemistry. 35: 14381-94. PMID 8916925 DOI: 10.1021/Bi961612S  0.457
1996 Johnson PE, Tomme P, Joshi MD, McIntosh LP. Interaction of soluble cellooligosaccharides with the N-terminal cellulose-binding domain of Cellulomonas fimi cenc. 2. NMR and ultraviolet absorption spectroscopy Biochemistry. 35: 13895-13906. PMID 8909286 DOI: 10.1021/Bi961186A  0.42
1996 Plesniak LA, Wakarchuk WW, Mcintosh LP. Secondary structure and NMR assignments of Bacillus circulans xylanase Protein Science. 5: 1118-1135. PMID 8762143 DOI: 10.1002/Pro.5560050614  0.384
1996 McIntosh LP, Hand G, Johnson PE, Joshi MD, Korner M, Plesniak LA, Ziser L, Wakarchuk WW, Withers SG. The pK(a) of the general acid/base carboxyl group of a glycosidase cycles during catalysis: A 13C-NMR study of Bacillus circulans xylanase Biochemistry. 35: 9958-9966. PMID 8756457 DOI: 10.1021/Bi9613234  0.373
1996 Skalicky JJ, Donaldson LW, Petersen JM, Graves BJ, McIntosh LP. Structural coupling of the inhibitory regions flanking the ETS domain of murine Ets-1 Protein Science. 5: 296-309. PMID 8745408 DOI: 10.1002/Pro.5560050214  0.49
1996 Donaldson LW, Petersen JM, Graves BJ, McIntosh LP. Solution structure of the ETS domain from murine Ets-1: A winged helix-turn-helix DNA binding motif Embo Journal. 15: 125-134. PMID 8598195 DOI: 10.1002/J.1460-2075.1996.Tb00340.X  0.479
1995 Wilkens S, Dahlquist FW, McIntosh LP, Donaldson LW, Capaldi RA. Structural features of the epsilon subunit of the Escherichia coli ATP synthase determined by NMR spectroscopy. Nature Structural Biology. 2: 961-7. PMID 7583669 DOI: 10.1038/Nsb1195-961  0.45
1995 Petersen JM, Skalicky JJ, Donaldson LW, McIntosh LP, Alber T, Gravest BJ. Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an α helix Science. 269: 1866-1869. PMID 7569926 DOI: 10.1126/Science.7569926  0.393
1994 Donaldson LW, Petersen JM, Graves BJ, McIntosh LP. Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn-helix DNA-binding proteins Biochemistry. 33: 13509-13516. PMID 7947760 DOI: 10.1021/Bi00250A001  0.499
1993 Pjura P, McIntosh LP, Wozniak JA, Matthews BW. Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties Proteins: Structure, Function and Genetics. 15: 401-412. PMID 8460110 DOI: 10.1002/Prot.340150407  0.408
1991 Schmieder P, Thanabal V, McIntosh LP, Dahlquist FW, Wagner G. Measurements of H.alpha.-HN vicinal coupling constants in a protein with large line widths in a new 3D 1H-15N-13C quadruple resonance NMR experiment Journal of the American Chemical Society. 113: 6323-6324. DOI: 10.1021/Ja00016A088  0.318
1990 Oas TG, McIntosh LP, O'Shea EK, Dahlquist FW, Kim PS. Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. Biochemistry. 29: 2891-4. PMID 2337572 DOI: 10.1021/Bi00464A001  0.375
1990 McIntosh LP, Wand AJ, Lowry DF, Redfield AG, Dahlquist FW. Assignment of the backbone 1H and 15N NMR resonances of bacteriophage T4 lysozyme. Biochemistry. 29: 6341-62. PMID 2207079 DOI: 10.1021/Bi00479A003  0.364
1990 McIntosh LP, Dahlquist FW. Biosynthetic incorporation of 15N and 13C for assignment and interpretation of nuclear magnetic resonance spectra of proteins. Quarterly Reviews of Biophysics. 23: 1-38. PMID 2188278 DOI: 10.1017/S0033583500005400  0.442
1990 Zuiderweg ERP, McIntosh LP, Dahlquist FW, Fesik SW. Three-dimensional 13C-resolved proton NOE spectroscopy of uniformly 13C-labeled proteins for the NMR assignment and structure determination of larger molecules Journal of Magnetic Resonance (1969). 86: 210-216. DOI: 10.1016/0022-2364(90)90228-2  0.395
1987 McIntosh LP, Dahlquist FW, Redfield AG. Proton NMR and NOE structural and dynamic studies of larger proteins and nucleic acids aided by isotope labels: T4 lysozyme. Journal of Biomolecular Structure & Dynamics. 5: 21-34. PMID 3271466 DOI: 10.1080/07391102.1987.10506372  0.329
1987 McIntosh LP, Griffey RH, Muchmore DC, Nielson CP, Redfield AG, Dahlquist FW. Proton NMR measurements of bacteriophage T4 lysozyme aided by 15N isotopic labeling: structural and dynamic studies of larger proteins. Proceedings of the National Academy of Sciences of the United States of America. 84: 1244-8. PMID 3029773 DOI: 10.1073/Pnas.84.5.1244  0.38
1987 Jovin TM, Soumpasis DM, McIntosh LP. The Transition Between B-DNA and Z-DNA Annual Review of Physical Chemistry. 38: 521-558. DOI: 10.1146/Annurev.Pc.38.100187.002513  0.33
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