F J. Sharom - Publications

Affiliations: 
University of Guelph (Canada), Guelph, Ontario, Canada 
Area:
Biochemistry

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Clay AT, Lu P, Sharom FJ. Interaction of the P-Glycoprotein Multidrug Transporter with Sterols. Biochemistry. 54: 6586-97. PMID 26484739 DOI: 10.1021/Acs.Biochem.5B00904  1
2014 Lugo MR, Sharom FJ. Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps. Plos One. 9: e98804. PMID 24897122 DOI: 10.1371/Journal.Pone.0098804  1
2014 Sharom FJ. Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function. Frontiers in Oncology. 4: 41. PMID 24624364 DOI: 10.3389/Fonc.2014.00041  1
2014 Emmert D, Campos CR, Ward D, Lu P, Namanja HA, Bohn K, Miller DS, Sharom FJ, Chmielewski J, Hrycyna CA. Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. Acs Chemical Neuroscience. 5: 305-17. PMID 24483607 DOI: 10.1021/Cn4002329  1
2014 Munagala S, Sirasani G, Kokkonda P, Phadke M, Krynetskaia N, Lu P, Sharom FJ, Chaudhury S, Abdulhameed MD, Tawa G, Wallqvist A, Martinez R, Childers W, Abou-Gharbia M, Krynetskiy E, et al. Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication. Bioorganic & Medicinal Chemistry. 22: 1148-55. PMID 24405813 DOI: 10.1016/J.Bmc.2013.12.022  1
2014 Lugo MR, Sharom FJ. Correction: Kinetic validation of the models for P-Glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps (PLoS ONE (2014) 9, 6 (e98804) DOI: 10.1371/journal.pone.0098804) Plos One. 9. DOI: 10.1371/journal.pone.0101836  1
2013 Cai P, Lu P, Sharom FJ, Fang WS. A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro. Cancer Letters. 341: 214-23. PMID 23941826 DOI: 10.1016/J.Canlet.2013.08.010  1
2013 Clay AT, Sharom FJ. Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. Biochemistry. 52: 343-54. PMID 23268645 DOI: 10.1021/Bi301532C  1
2012 Melchior DL, Sharom FJ, Evers R, Wright GE, Chu JW, Wright SE, Chu X, Yabut J. Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers. Journal of Pharmacological and Toxicological Methods. 65: 64-74. PMID 22394995 DOI: 10.1016/J.Vascn.2012.02.002  1
2012 Thompson MD, Roscioli T, Marcelis C, Nezarati MM, Stolte-Dijkstra I, Sharom FJ, Lu P, Phillips JA, Sweeney E, Robinson PN, Krawitz P, Yntema HG, Andrade DM, Brunner HG, Cole DE. Phenotypic variability in hyperphosphatasia with seizures and neurologic deficit (Mabry syndrome). American Journal of Medical Genetics. Part A. 158: 553-8. PMID 22315194 DOI: 10.1002/Ajmg.A.35202  1
2012 King G, Sharom FJ. Proteins that bind and move lipids: MsbA and NPC1. Critical Reviews in Biochemistry and Molecular Biology. 47: 75-95. PMID 22117698 DOI: 10.3109/10409238.2011.636505  1
2012 Juhasz J, Davis JH, Sharom FJ. Fluorescent probe partitioning in GUVs of binary phospholipid mixtures: implications for interpreting phase behavior. Biochimica Et Biophysica Acta. 1818: 19-26. PMID 21945563 DOI: 10.1016/J.Bbamem.2011.09.006  1
2011 Sharom FJ. The P-glycoprotein multidrug transporter. Essays in Biochemistry. 50: 161-78. PMID 21967057 DOI: 10.1042/Bse0500161  1
2011 Sharom FJ. Flipping and flopping--lipids on the move. Iubmb Life. 63: 736-46. PMID 21793163 DOI: 10.1002/Iub.515  1
2011 Xiao X, Wu J, Trigili C, Chen H, Chu JW, Zhao Y, Lu P, Sheng L, Li Y, Sharom FJ, Barasoain I, Diaz JF, Fang WS. Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport. Bioorganic & Medicinal Chemistry Letters. 21: 4852-6. PMID 21764308 DOI: 10.1016/J.Bmcl.2011.06.034  1
2010 Goard CA, Mather RG, Vinepal B, Clendening JW, Martirosyan A, Boutros PC, Sharom FJ, Penn LZ. Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. International Journal of Cancer. 127: 2936-48. PMID 21351272 DOI: 10.1002/Ijc.25295  1
2010 Juhasz J, Davis JH, Sharom FJ. Fluorescent probe partitioning in giant unilamellar vesicles of 'lipid raft' mixtures. The Biochemical Journal. 430: 415-23. PMID 20642452 DOI: 10.1042/Bj20100516  1
2010 Sharom FJ, Liu R, Vinepal B. Fluorescence studies of drug binding and translocation by membrane transporters. Methods in Molecular Biology (Clifton, N.J.). 637: 133-48. PMID 20419433 DOI: 10.1007/978-1-60761-700-6_7  1
2010 Eckford PD, Sharom FJ. The reconstituted Escherichia coli MsbA protein displays lipid flippase activity. The Biochemical Journal. 429: 195-203. PMID 20412049 DOI: 10.1042/Bj20100144  1
2010 Siarheyeva A, Liu R, Sharom FJ. Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis. The Journal of Biological Chemistry. 285: 7575-86. PMID 20061384 DOI: 10.1074/Jbc.M109.047290  1
2010 Sharom FJ. GPI-anchored proteins: Biophysical behaviour and cleavage by PI-specific phospholipases Gpi Membrane Anchors-the Much Needed Link: a Biological, Structural, Physical and Chemical Look At Glycosylphosphatidylinositol-Anchored Proteins and Their Influences and Potential Applications in Biotechnology and Biomedicine. 34-52. DOI: 10.2174/978160805123611001010034  1
2009 Juhasz J, Sharom FJ, Davis JH. Quantitative characterization of coexisting phases in DOPC/DPPC/cholesterol mixtures: comparing confocal fluorescence microscopy and deuterium nuclear magnetic resonance. Biochimica Et Biophysica Acta. 1788: 2541-52. PMID 19837045 DOI: 10.1016/J.Bbamem.2009.10.006  1
2009 Lugo MR, Sharom FJ. Interaction of LDS-751 with the drug-binding site of P-glycoprotein: a Trp fluorescence steady-state and lifetime study. Archives of Biochemistry and Biophysics. 492: 17-28. PMID 19818729 DOI: 10.1016/J.Abb.2009.10.002  1
2009 Eckford PD, Sharom FJ. ABC efflux pump-based resistance to chemotherapy drugs. Chemical Reviews. 109: 2989-3011. PMID 19583429 DOI: 10.1021/Cr9000226  1
2009 Siarheyeva A, Sharom FJ. The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites. The Biochemical Journal. 419: 317-28. PMID 19132955 DOI: 10.1042/Bj20081364  1
2009 Liu R, Lu P, Chu JW, Sharom FJ. Characterization of fluorescent sterol binding to purified human NPC1. The Journal of Biological Chemistry. 284: 1840-52. PMID 19029290 DOI: 10.1074/Jbc.M803741200  1
2008 Eckford PD, Sharom FJ. Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport. Biochemistry. 47: 13686-98. PMID 19049391 DOI: 10.1021/Bi801409R  1
2008 Eckford PD, Sharom FJ. Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates. The Journal of Biological Chemistry. 283: 12840-50. PMID 18344567 DOI: 10.1074/Jbc.M708274200  1
2008 Sharom FJ. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics. 9: 105-27. PMID 18154452 DOI: 10.2217/14622416.9.1.105  1
2007 Sreeramulu K, Liu R, Sharom FJ. Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochimica Et Biophysica Acta. 1768: 1750-7. PMID 17490606 DOI: 10.1016/J.Bbamem.2007.04.001  1
2007 Yang CG, Barasoain I, Li X, Matesanz R, Liu R, Sharom FJ, Yin DL, Díaz JF, Fang WS. Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines. Chemmedchem. 2: 691-701. PMID 17385753 DOI: 10.1002/Cmdc.200700002  1
2006 Eckford PD, Sharom FJ. P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 84: 1022-33. PMID 17215888 DOI: 10.1139/o06-196  1
2006 Sharom FJ. Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1). Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 84: 979-92. PMID 17215884 DOI: 10.1139/o06-199  1
2006 Russell PL, Sharom FJ. Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter. The Biochemical Journal. 399: 315-23. PMID 16803457 DOI: 10.1042/Bj20060015  1
2006 Blonder J, Yu LR, Radeva G, Chan KC, Lucas DA, Waybright TJ, Issaq HJ, Sharom FJ, Veenstra TD. Combined chemical and enzymatic stable isotope labeling for quantitative profiling of detergent-insoluble membrane proteins isolated using Triton X-100 and Brij-96. Journal of Proteome Research. 5: 349-60. PMID 16457601 DOI: 10.1021/Pr050355N  1
2006 Sharom FJ. Multidrug Resistance Protein: P-Glycoprotein Drug Transporters: Molecular Characterization and Role in Drug Disposition. 223-262. DOI: 10.1002/9780470140505.ch10  1
2005 Sharom FJ, Lugo MR, Eckford PD. New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter. Journal of Bioenergetics and Biomembranes. 37: 481-7. PMID 16691487 DOI: 10.1007/S10863-005-9496-6  1
2005 Lugo MR, Sharom FJ. Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. Biochemistry. 44: 14020-9. PMID 16229491 DOI: 10.1021/Bi0511179  1
2005 Radeva G, Perabo J, Sharom FJ. P-Glycoprotein is localized in intermediate-density membrane microdomains distinct from classical lipid rafts and caveolar domains. The Febs Journal. 272: 4924-37. PMID 16176266 DOI: 10.1111/J.1742-4658.2005.04905.X  1
2005 Eckford PD, Sharom FJ. The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. The Biochemical Journal. 389: 517-26. PMID 15799713 DOI: 10.1042/Bj20050047  1
2005 Dalmas O, Do Cao MA, Lugo MR, Sharom FJ, Di Pietro A, Jault JM. Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer. Biochemistry. 44: 4312-21. PMID 15766260 DOI: 10.1021/Bi0482809  1
2005 Lugo MR, Sharom FJ. Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site. Biochemistry. 44: 643-55. PMID 15641790 DOI: 10.1021/Bi0485326  1
2005 Lugo MR, Liu R, Sharom FJ. Kinetic of the binding of H33342 to the P-glycoprotein. Detection and analysis of progress curves Acta Cientifica Venezolana. 56: 159-167.  1
2004 Muñoz-Martínez F, Lu P, Cortés-Selva F, Pérez-Victoria JM, Jiménez IA, Ravelo AG, Sharom FJ, Gamarro F, Castanys S. Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance. Cancer Research. 64: 7130-8. PMID 15466210 DOI: 10.1158/0008-5472.CAN-04-1005  1
2004 Sharom FJ, Radeva G. GPI-anchored protein cleavage in the regulation of transmembrane signals. Sub-Cellular Biochemistry. 37: 285-315. PMID 15376625 DOI: 10.1007/978-1-4757-5806-1_9  1
2004 van der Ende BM, Sharom FJ, Davis JH. The transmembrane domain of Neu in a lipid bilayer: molecular dynamics simulations. European Biophysics Journal : Ebj. 33: 596-610. PMID 15197512 DOI: 10.1007/S00249-004-0407-2  1
2004 Houliston RS, Hodges RS, Sharom FJ, Davis JH. Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles. The Journal of Biological Chemistry. 279: 24073-80. PMID 15051716 DOI: 10.1074/Jbc.M401919200  1
2004 Radeva G, Sharom FJ. Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells. The Biochemical Journal. 380: 219-30. PMID 14769131 DOI: 10.1042/Bj20031348  1
2003 Gieswein CE, Sharom FJ, Wildeman AG. Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions. Virology. 313: 415-26. PMID 12954209 DOI: 10.1016/S0042-6822(03)00296-4  1
2003 Sharom FJ, Russell PL, Qu Q, Lu P. Fluorescence techniques for studying membrane transport proteins: the P-glycoprotein multidrug transporter. Methods in Molecular Biology (Clifton, N.J.). 227: 109-28. PMID 12824647 DOI: 10.1385/1-59259-387-9:109  1
2003 Yang DH, Wildeman AG, Sharom FJ. Overexpression, purification, and structural analysis of the hydrophobic E5 protein from human papillomavirus type 16. Protein Expression and Purification. 30: 1-10. PMID 12821315 DOI: 10.1016/S1046-5928(03)00049-4  1
2003 Qu Q, Chu JW, Sharom FJ. Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism. Biochemistry. 42: 1345-53. PMID 12564938 DOI: 10.1021/Bi0267745  1
2003 Houliston RS, Hodges RS, Sharom FJ, Davis JH. Comparison of proto-oncogenic and mutant forms of the transmembrane region of the Neu receptor in TFE. Febs Letters. 535: 39-43. PMID 12560075 DOI: 10.1016/S0014-5793(02)03852-8  1
2003 Qu Q, Russell PL, Sharom FJ. Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle. Biochemistry. 42: 1170-7. PMID 12549939 DOI: 10.1021/Bi026555J  1
2002 Sharom FJ, Lehto MT. Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 80: 535-49. PMID 12440695 DOI: 10.1139/O02-146  1
2002 Farès C, Sharom FJ, Davis JH. 15N,(1)H Heteronuclear correlation NMR of gramicidin A in DMPC-d(67). Journal of the American Chemical Society. 124: 11232-3. PMID 12236713 DOI: 10.1021/Ja0264549  1
2002 Lehto MT, Sharom FJ. Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study. Biochemistry. 41: 8368-76. PMID 12081485 DOI: 10.1021/Bi012038+  1
2002 Qu Q, Sharom FJ. Proximity of bound Hoechst 33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet. Biochemistry. 41: 4744-52. PMID 11926837 DOI: 10.1021/Bi0120897  1
2002 Lehto MT, Sharom FJ. PI-specific phospholipase C cleavage of a reconstituted GPI-anchored protein: modulation by the lipid bilayer. Biochemistry. 41: 1398-408. PMID 11802743 DOI: 10.1021/Bi011579W  1
2001 Sharom FJ, Liu R, Qu Q, Romsicki Y. Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools. Seminars in Cell & Developmental Biology. 12: 257-65. PMID 11428918 DOI: 10.1006/Scdb.2000.0251  1
2001 Romsicki Y, Sharom FJ. Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter. Biochemistry. 40: 6937-47. PMID 11389609 DOI: 10.1021/Bi0024456  1
2001 Rybczynska M, Liu R, Lu P, Sharom FJ, Steinfels E, Pietro AD, Spitaler M, Grunicke H, Hofmann J. MDR1 causes resistance to the antitumour drug miltefosine. British Journal of Cancer. 84: 1405-11. PMID 11355955 DOI: 10.1054/Bjoc.2001.1776  1
2001 Lu P, Liu R, Sharom FJ. Drug transport by reconstituted P-glycoprotein in proteoliposomes. Effect of substrates and modulators, and dependence on bilayer phase state. European Journal of Biochemistry / Febs. 268: 1687-97. PMID 11248688 DOI: 10.1046/J.1432-1327.2001.02041.X  1
2001 Lam FC, Liu R, Lu P, Shapiro AB, Renoir JM, Sharom FJ, Reiner PB. beta-Amyloid efflux mediated by p-glycoprotein. Journal of Neurochemistry. 76: 1121-8. PMID 11181832 DOI: 10.1046/J.1471-4159.2001.00113.X  1
2001 Qu Q, Sharom FJ. FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated. Biochemistry. 40: 1413-22. PMID 11170469 DOI: 10.1021/Bi002035H  1
2000 Liu R, Siemiarczuk A, Sharom FJ. Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides. Biochemistry. 39: 14927-38. PMID 11101309 DOI: 10.1021/Bi0018786  1
1999 Sharom FJ, Liu R, Romsicki Y, Lu P. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies. Biochimica Et Biophysica Acta. 1461: 327-45. PMID 10581365 DOI: 10.1016/S0005-2736(99)00166-2  1
1999 Reid-Taylor KL, Chu JW, Sharom FJ. Reconstitution of the glycosylphosphatidylinositol-anchored protein Thy-1: interaction with membrane phospholipids and galactosylceramide. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 77: 189-200. PMID 10505789  1
1999 Sharom FJ, Yu X, Lu P, Liu R, Chu JW, Szabó K, Müller M, Hose CD, Monks A, Váradi A, Seprôdi J, Sarkadi B. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells. Biochemical Pharmacology. 58: 571-86. PMID 10413294 DOI: 10.1016/S0006-2952(99)00139-2  1
1999 Romsicki Y, Sharom FJ. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry. 38: 6887-96. PMID 10346910 DOI: 10.1021/Bi990064Q  1
1998 Sharom FJ, Liu R, Romsicki Y. Spectroscopic and biophysical approaches for studying the structure and function of the P-glycoprotein multidrug transporter. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 76: 695-708. PMID 10353701 DOI: 10.1139/bcb-76-5-695  1
1998 Roepe PD, Sharom FJ. The P-glycoprotein efflux pump: How does it transport drugs? (multiple letters) Journal of Membrane Biology. 166: 71-73. PMID 9784587 DOI: 10.1007/S002329900448  1
1998 Romsicki Y, Sharom FJ. The ATPase and ATP-binding functions of P-glycoprotein--modulation by interaction with defined phospholipids. European Journal of Biochemistry / Febs. 256: 170-8. PMID 9746361 DOI: 10.1046/J.1432-1327.1998.2560170.X  1
1998 Sharom FJ, Lu P, Liu R, Yu X. Linear and cyclic peptides as substrates and modulators of P-glycoprotein: peptide binding and effects on drug transport and accumulation. The Biochemical Journal. 333: 621-30. PMID 9677321 DOI: 10.1042/Bj3330621  1
1998 Lehto MT, Sharom FJ. Release of the glycosylphosphatidylinositol-anchored enzyme ecto-5'-nucleotidase by phospholipase C: catalytic activation and modulation by the lipid bilayer. The Biochemical Journal. 332: 101-9. PMID 9576857 DOI: 10.1042/Bj3320101  1
1998 Liu R, Sharom FJ. Proximity of the nucleotide binding domains of the P-glycoprotein multidrug transporter to the membrane surface: a resonance energy transfer study. Biochemistry. 37: 6503-12. PMID 9572868 DOI: 10.1021/Bi973031O  1
1997 Sharom FJ. The P-glycoprotein efflux pump: how does it transport drugs? The Journal of Membrane Biology. 160: 161-75. PMID 9425600 DOI: 10.1007/S002329900305  1
1997 Sharom FJ. The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity. Biochemical Society Transactions. 25: 1088-96. PMID 9388605  1
1997 DiDiodato G, Sharom FJ. Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter. Biochemical Pharmacology. 53: 1789-97. PMID 9256153 DOI: 10.1016/S0006-2952(97)00007-5  1
1997 Romsicki Y, Sharom FJ. Interaction of P-glycoprotein with defined phospholipid bilayers: a differential scanning calorimetric study. Biochemistry. 36: 9807-15. PMID 9245413 DOI: 10.1021/Bi963120L  1
1997 Liu R, Sharom FJ. Fluorescence studies on the nucleotide binding domains of the P-glycoprotein multidrug transporter. Biochemistry. 36: 2836-43. PMID 9062112 DOI: 10.1021/Bi9627119  1
1997 Chu JW, Sharom FJ, Oriol JG, Betteridge KJ, Cleaver BD, Sharp DC. Biochemical changes in the equine capsule following prostaglandin-induced pregnancy failure. Molecular Reproduction and Development. 46: 286-95. PMID 9041131 DOI: 10.1002/(Sici)1098-2795(199703)46:3<286::Aid-Mrd7>3.0.Co;2-L  1
1996 Sharom FJ, McNeil GL, Glover JR, Seier S. Modulation of the cleavage of glycosylphosphatidylinositol-anchored proteins by specific bacterial phospholipases. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 74: 701-13. PMID 9018379 DOI: 10.1139/O96-077  1
1996 Sharom FJ, Yu X, DiDiodato G, Chu JW. Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport. The Biochemical Journal. 320: 421-8. PMID 8973548 DOI: 10.1042/Bj3200421  1
1996 Lu P, Sharom FJ. Immunosuppression by YAC-1 lymphoma: role of shed gangliosides. Cellular Immunology. 173: 22-32. PMID 8871598 DOI: 10.1006/Cimm.1996.0248  1
1996 Liu R, Sharom FJ. Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains. Biochemistry. 35: 11865-73. PMID 8794769 DOI: 10.1021/Bi960823U  1
1996 Wybenga LE, Epand RF, Nir S, Chu JW, Sharom FJ, Flanagan TD, Epand RM. Glycophorin as a receptor for Sendai virus. Biochemistry. 35: 9513-8. PMID 8755731 DOI: 10.1021/Bi9606152  1
1995 Lu P, Sharom FJ. Gangliosides are potent immunosuppressors of IL-2-mediated T-cell proliferation in a low protein environment. Immunology. 86: 356-63. PMID 8550071  1
1995 Sharom FJ, Yu X, Chu JW, Doige CA. Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. The Biochemical Journal. 308: 381-90. PMID 7772017 DOI: 10.1042/Bj3080381  1
1995 Chu JW, Sharom FJ. Gangliosides interact with interleukin-4 and inhibit interleukin-4-stimulated helper T-cell proliferation. Immunology. 84: 396-403. PMID 7751022  1
1995 Sharom FJ, DiDiodato G, Yu X, Ashbourne KJ. Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores. The Journal of Biological Chemistry. 270: 10334-41. PMID 7730340 DOI: 10.1074/Jbc.270.17.10334  1
1995 Sharom FJ. Characterization and functional reconstitution of the multidrug transporter. Journal of Bioenergetics and Biomembranes. 27: 15-22. PMID 7629046 DOI: 10.1007/Bf02110326  1
1994 Shan X, Davis JH, Chu JW, Sharom FJ. 2H-NMR investigation of DMPC/glycophorin bilayers. Biochimica Et Biophysica Acta. 1193: 127-37. PMID 8038182 DOI: 10.1016/0005-2736(94)90341-7  1
1994 Loe DW, Sharom FJ. Interaction of multidrug-resistant Chinese hamster ovary cells with the peptide ionophore gramicidin D. Biochimica Et Biophysica Acta. 1190: 72-84. PMID 7509193 DOI: 10.1016/0005-2736(94)90035-3  1
1993 Chu JW, Sharom FJ. Gangliosides inhibit T-lymphocyte proliferation by preventing the interaction of interleukin-2 with its cell surface receptors. Immunology. 79: 10-7. PMID 8509130  1
1993 Oriol JG, Betteridge KJ, Clarke AJ, Sharom FJ. Mucin-like glycoproteins in the equine embryonic capsule. Molecular Reproduction and Development. 34: 255-65. PMID 8471247 DOI: 10.1002/Mrd.1080340305  1
1993 Loe DW, Sharom FJ. Interaction of multidrug-resistant Chinese hamster ovary cells with amphiphiles. British Journal of Cancer. 68: 342-51. PMID 8347489 DOI: 10.1038/bjc.1993.338  1
1993 Oriol JG, Sharom FJ, Betteridge KJ. Developmentally regulated changes in the glycoproteins of the equine embryonic capsule. Journal of Reproduction and Fertility. 99: 653-64. PMID 8107051 DOI: 10.1530/Jrf.0.0990653  1
1993 Doige CA, Yu X, Sharom FJ. The effects of lipids and detergents on ATPase-active P-glycoprotein. Biochimica Et Biophysica Acta. 1146: 65-72. PMID 8095161 DOI: 10.1016/0005-2736(93)90339-2  1
1993 Sharom FJ, Yu X, Doige CA. Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein. The Journal of Biological Chemistry. 268: 24197-202. PMID 7901214  1
1992 Chu JW, Sharom FJ. Glycophorin A interacts with interleukin-2 and inhibits interleukin-2-dependent T-lymphocyte proliferation. Cellular Immunology. 145: 223-39. PMID 1451177 DOI: 10.1016/0008-8749(92)90327-L  1
1992 Doige CA, Sharom FJ. Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 1109: 161-71. PMID 1355667 DOI: 10.1016/0005-2736(92)90079-2  1
1992 Doige CA, Yu X, Sharom FJ. ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 1109: 149-60. PMID 1355666 DOI: 10.1016/0005-2736(92)90078-Z  1
1991 Chu JW, Sharom FJ. Effect of micellar and bilayer gangliosides on proliferation of interleukin-2-dependent lymphocytes. Cellular Immunology. 132: 319-38. PMID 1988158 DOI: 10.1016/0008-8749(91)90031-6  1
1991 Sharom FJ, Chiu AL, Chu JW. Membrane gangliosides modulate interleukin-2-stimulated T-lymphocyte proliferation. Biochimica Et Biophysica Acta. 1094: 35-42. PMID 1832018 DOI: 10.1016/0167-4889(91)90023-Q  1
1991 Doige CA, Sharom FJ. Strategies for the purification of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Protein Expression and Purification. 2: 256-65. PMID 1687982 DOI: 10.1016/1046-5928(91)90081-S  1
1990 Georges E, Sharom FJ, Ling V. Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy. Advances in Pharmacology (San Diego, Calif.). 21: 185-220. PMID 2265126 DOI: 10.1016/S1054-3589(08)60343-9  1
1990 Chu JW, Sharom FJ. Interleukin-2 binds to gangliosides in micelles and lipid bilayers. Biochimica Et Biophysica Acta. 1028: 205-14. PMID 2223793 DOI: 10.1016/0005-2736(90)90168-N  1
1990 Sharom FJ, Chiu AL, Ross TE. Gangliosides and glycophorin inhibit T-lymphocyte activation. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 68: 735-44. PMID 2222998 DOI: 10.1139/O90-106  1
1989 Sharom FJ, Head S, Kupsh CC, Williams L. Interaction of concanavalin A and a divalent derivative with lymphocytes and reconstituted lymphocyte membrane glycoproteins. Membrane Biochemistry. 8: 147-63. PMID 2641950 DOI: 10.3109/09687688909025828  1
1989 Loe DW, Glover JR, Head S, Sharom FJ. Solubilization, characterization, and detergent interactions of lymphocyte 5'-nucleotidase. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 67: 214-23. PMID 2550035 DOI: 10.1139/O89-033  1
1988 Sharom FJ, Lamb MP, Kupsh CC, Head S. Inhibition of lymphocyte 5'-nucleotidase by lectins: effects of lectin specificity and cross-linking ability. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 66: 715-23. PMID 2846011 DOI: 10.1139/O88-082  1
1986 Morrow MR, Davis JH, Sharom FJ, Lamb MP. Studies on the interaction of human erythrocyte band 3 with membrane lipids using deuterium nuclear magnetic resonance and differential scanning calorimetry. Biochimica Et Biophysica Acta. 858: 13-20. PMID 3707958 DOI: 10.1016/0005-2736(86)90286-5  1
1986 Sharom FJ, Ross TE. Association of gangliosides with the lymphocyte plasma membrane studied using radiolabels and spin labels. Biochimica Et Biophysica Acta. 854: 287-97. PMID 3002469 DOI: 10.1016/0005-2736(86)90122-7  1
1985 Chicken CA, Sharom FJ. Effects of bovine serum albumin on the interaction of concanavalin A and succinyl-concanavalin A with phospholipid bilayers. Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire. 63: 64-70. PMID 3986663 DOI: 10.1139/o85-009  1
1985 Chicken CA, Sharom FJ. Interaction of human erythrocyte Band 3 with Ricinus communis agglutinin and other lectins. Biochimica Et Biophysica Acta. 814: 125-34. PMID 3978096 DOI: 10.1016/0005-2736(85)90427-4  1
1985 Sharom FJ, Lorimer I, Lamb MP. Reconstitution of lymphocyte 5'-nucleotidase in lipid bilayers: behaviour and interaction with concanavalin A. Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire. 63: 1049-57. PMID 3000546 DOI: 10.1139/o85-130  1
1985 Sharom FJ, Ross TE. Spin labelling of sialic acid and galactose residues on lymphocyte plasma membrane: effects of lectins on oligosaccharide dynamics. Molecular Immunology. 22: 521-30. PMID 2991754 DOI: 10.1016/0161-5890(85)90175-0  1
1985 Sharom FJ, Ross TE. Inhibition of lymphocyte activation by gangliosides and glycophorin Federation Proceedings. 44.  1
1984 Chicken CA, Sharom FJ. Lipid-protein interactions of the human erythrocyte concanavalin A receptor in phospholipid bilayers. Biochimica Et Biophysica Acta. 774: 110-8. PMID 6733102 DOI: 10.1016/0005-2736(84)90281-5  1
1984 Sadler MC, Sharom FJ, Mellors A. Inhibition of mouse lymphocyte 5'-nucleotidase by cannabinoids: a physical toxicity effect. Biochemical Pharmacology. 33: 1685-7. PMID 6329213 DOI: 10.1016/0006-2952(84)90293-4  1
1983 Campbell CD, Ross TE, Sharom FJ. Functional reassembly of lymphocyte lentil lectin receptor glycoproteins into lipid bilayer vesicles. Biochimica Et Biophysica Acta. 730: 95-103. PMID 6830799 DOI: 10.1016/0005-2736(83)90321-8  1
1983 Chicken CA, Sharom FJ. The concanavalin a receptor from human erythrocytes in lipid bilayer membranes. Interaction with concanavalin A and succinyl-concanavalin A Bba - Biomembranes. 729: 200-208. PMID 6830787 DOI: 10.1016/0005-2736(83)90486-8  1
1980 Sharom FJ, Mellors A. Effects of polychlorinated biphenyls on biological membranes. Physical toxicity and molar volume relationships Biochemical Pharmacology. 29: 3311-3317. PMID 6260110 DOI: 10.1016/0006-2952(80)90309-3  1
1979 Damji SWH, Fyfe CA, Smith D, Sharom FJ. Nuclear magnetic resonance investigation of the adducts formed by the attack of carbanions on substituted pyridinium ions Journal of Organic Chemistry. 44: 1761-1765.  1
1978 Barratt DG, Rogers JD, Sharom FJ, Grant CWM. Direct modification of the glycocalyx of a cultured muscle cell line by incorporayion of foreign gangliosides and an integral membrane glycoprotein Journal of Supramolecular and Cellular Biochemistry. 8: 119-128. PMID 569743 DOI: 10.1002/Jss.400080110  1
1978 Sharom FJ, Grant CWM. A model for ganglioside behaviour in cell membranes Bba - Biomembranes. 507: 280-293. PMID 203316 DOI: 10.1016/0005-2736(78)90423-6  1
1978 Barratt DG, Rogers JD, Sharom FJ, Grant CWM. Incorporation of foreign carbohydrate-bearing components into the membrane of myoblasts in culture Annals of the New York Academy of Sciences. 441.  1
1977 Sharom FJ, Grant CWM. Glycosphingolipids in membrane architecture Journal of Supramolecular and Cellular Biochemistry. 6: 249-258. PMID 198615 DOI: 10.1002/Jss.400060210  1
1977 Sharom FJ, Grant CWM. A ganglioside spin label: Ganglioside head group interactions Biochemical and Biophysical Research Communications. 74: 1039-1045. PMID 191002 DOI: 10.1016/0006-291X(77)91622-9  1
1976 Sharom FJ, Barratt DG, Thede AE, Grant CWM. Glycolipids in model membranes Spin label and Freeze-Etch studies Bba - Biomembranes. 455: 485-492. PMID 187242 DOI: 10.1016/0005-2736(76)90319-9  1
1976 Colter AK, Saito G, Sharom FJ, Hong AP. Hydride transfer reactions. Oxidation of N-methylacridan by 1,4-benzoquinone and related π acceptors [13] Journal of the American Chemical Society. 98: 7833-7835.  1
1975 Sharom FJ, Grant CWM. A glycosphingolipid spin label: Ca2+ effects on sphingolipid distribution in bilayers containing phosphatidyl serine Biochemical and Biophysical Research Communications. 67: 1501-1506. PMID 173343 DOI: 10.1016/0006-291X(75)90196-5  1
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