Daniela Rotin - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Biochemistry

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Demian WL, Persaud A, Jiang C, Coyaud É, Liu S, Kapus A, Kafri R, Raught B, Rotin D. The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. Cell Reports. 27: 1886-1896.e6. PMID 31067471 DOI: 10.1016/j.celrep.2019.04.034  1
2018 Wasserman SS, Shteiman-Kotler A, Harris K, Iliadi KG, Persaud A, Zhong Y, Zhang Y, Fang X, Boulianne GL, Stewart B, Rotin D. Regulation of SH3PX1 by dNedd4-long at the Neuromuscular Junction. The Journal of Biological Chemistry. PMID 30518551 DOI: 10.1074/jbc.RA118.005161  1
2017 Attali I, Tobelaim WS, Persaud A, Motamedchaboki K, Simpson-Lavy KJ, Mashahreh B, Levin-Kravets O, Keren-Kaplan T, Pilzer I, Kupiec M, Wiener R, Wolf DA, Rotin D, Prag G. Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases. The Embo Journal. PMID 28069708 DOI: 10.15252/embj.201694314  1
2016 Lu C, Thoeni C, Connor A, Kawabe H, Gallinger S, Rotin D. Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors. Oncogene. PMID 27086928 DOI: 10.1038/onc.2016.125  1
2016 Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, ... ... Rotin D, et al. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell. PMID 26949039 DOI: 10.1016/j.molcel.2016.02.005  1
2016 Safi F, Shteiman-Kotler A, Zhong Y, Iliadi KG, Boulianne GL, Rotin D. Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation. Molecular Biology of the Cell. PMID 26823013 DOI: 10.1091/mbc.E15-06-0420  1
2015 Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nature Communications. 6: 7250. PMID 25998567 DOI: 10.1038/ncomms8250  1
2015 Trzci?ska-Daneluti AM, Chen A, Nguyen L, Murchie R, Jiang C, Moffat J, Pelletier L, Rotin D. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Molecular & Cellular Proteomics : McP. 14: 1569-83. PMID 25825526 DOI: 10.1074/mcp.M114.046375  1
2015 Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY. Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 14: 16-25. PMID 24974227 DOI: 10.1016/j.jcf.2014.06.001  1
2014 Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nature Cell Biology. 16: 1227-37. PMID 25344756 DOI: 10.1038/ncb3054  1
2014 Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D. Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity. Science Signaling. 7: ra95. PMID 25292214 DOI: 10.1126/scisignal.2005290  1
2014 Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, et al. Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 13205-10. PMID 25157163 DOI: 10.1073/pnas.1400737111  1
2014 Murchie R, Guo CH, Persaud A, Muise A, Rotin D. Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability. Proceedings of the National Academy of Sciences of the United States of America. 111: 693-8. PMID 24385580 DOI: 10.1073/pnas.1315017111  1
2013 Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, Hofmann K, Rotin D, Pedrioli P, Swedlow JR, Peter M, Sumara I. Ubiquitylation-dependent localization of PLK1 in mitosis. Nature Cell Biology. 15: 430-9. PMID 23455478 DOI: 10.1038/ncb2695  1
2013 Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Rotin D, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/science.1230161  1
2012 Nagpal P, Plant PJ, Correa J, Bain A, Takeda M, Kawabe H, Rotin D, Bain JR, Batt JA. The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. Plos One. 7: e46427. PMID 23110050 DOI: 10.1371/journal.pone.0046427  1
2012 Rotin D, Staub O. Nedd4-2 and the regulation of epithelial sodium transport. Frontiers in Physiology. 3: 212. PMID 22737130 DOI: 10.3389/fphys.2012.00212  1
2012 Glowacka WK, Alberts P, Ouchida R, Wang JY, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. The Journal of Biological Chemistry. 287: 27691-702. PMID 22733818 DOI: 10.1074/jbc.M112.355917  1
2012 Trzcinska-Daneluti AM, Nguyen L, Jiang C, Fladd C, Uehling D, Prakesch M, Al-awar R, Rotin D. Use of kinase inhibitors to correct ΔF508-CFTR function. Molecular & Cellular Proteomics : McP. 11: 745-57. PMID 22700489 DOI: 10.1074/mcp.M111.016626  1
2011 Zhong Y, Shtineman-Kotler A, Nguyen L, Iliadi KG, Boulianne GL, Rotin D. A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. Plos One. 6: e27007. PMID 22110599 DOI: 10.1371/journal.pone.0027007  1
2011 Milkereit R, Rotin D. A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins. Plos One. 6: e27478. PMID 22096579 DOI: 10.1371/journal.pone.0027478  1
2011 Persaud A, Rotin D. Use of proteome arrays to globally identify substrates for E3 ubiquitin ligases. Methods in Molecular Biology (Clifton, N.J.). 759: 215-24. PMID 21863490 DOI: 10.1007/978-1-61779-173-4_13  1
2011 Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. The Embo Journal. 30: 3259-73. PMID 21765395 DOI: 10.1038/emboj.2011.234  1
2011 Kimura T, Kawabe H, Jiang C, Zhang W, Xiang YY, Lu C, Salter MW, Brose N, Lu WY, Rotin D. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 3216-21. PMID 21300902 DOI: 10.1073/pnas.1010334108  1
2011 Rotin D, Staub O. Role of the ubiquitin system in regulating ion transport. PflüGers Archiv : European Journal of Physiology. 461: 1-21. PMID 20972579 DOI: 10.1007/s00424-010-0893-2  1
2010 Alberts P, Rotin D. Regulation of lipid droplet turnover by ubiquitin ligases. Bmc Biology. 8: 94. PMID 20646264 DOI: 10.1186/1741-7007-8-94  1
2010 Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW. Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine. Molecular Pharmacology. 77: 922-30. PMID 20200141 DOI: 10.1124/mol.109.062679  1
2010 Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. The Journal of Biological Chemistry. 285: 6770-80. PMID 20026598 DOI: 10.1074/jbc.M109.082347  1
2009 Persaud A, Alberts P, Amsen EM, Xiong X, Wasmuth J, Saadon Z, Fladd C, Parkinson J, Rotin D. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Molecular Systems Biology. 5: 333. PMID 19953087 DOI: 10.1038/msb.2009.85  1
2009 Schimmer AD, Malkin D, Zackenhaus E, Kagal A, Klip A, Rotin D, Minden MD, Teitel J. Health care crisis in Gaza. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 180: 1230. PMID 19506287 DOI: 10.1503/cmaj.1090038  1
2009 Kim Chiaw P, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE. Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs. Chemistry & Biology. 16: 520-30. PMID 19477416 DOI: 10.1016/j.chembiol.2009.04.005  1
2009 Rotin D, Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nature Reviews. Molecular Cell Biology. 10: 398-409. PMID 19436320 DOI: 10.1038/nrm2690  1
2009 Muise AM, Walters TD, Glowacka WK, Griffiths AM, Ngan BY, Lan H, Xu W, Silverberg MS, Rotin D. Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease. Gut. 58: 1121-7. PMID 19398441 DOI: 10.1136/gut.2008.175117  1
2009 Trzcinska-Daneluti AM, Ly D, Huynh L, Jiang C, Fladd C, Rotin D. High-content functional screen to identify proteins that correct F508del-CFTR function. Molecular & Cellular Proteomics : McP. 8: 780-90. PMID 19088066 DOI: 10.1074/mcp.M800268-MCP200  1
2008 Rotin D. Role of the UPS in Liddle syndrome. Bmc Biochemistry. 9: S5. PMID 19007435 DOI: 10.1186/1471-2091-9-S1-S5  1
2008 Rotin D, Schild L. ENaC and its regulatory proteins as drug targets for blood pressure control. Current Drug Targets. 9: 709-16. PMID 18691017 DOI: 10.2174/138945008785132367  1
2008 Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD. Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 47: 8937-49. PMID 18680311 DOI: 10.1021/bi800439t  1
2008 Muise A, Rotin D. Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene. Expert Review of Molecular Diagnostics. 8: 465-77. PMID 18598228 DOI: 10.1586/14737159.8.4.465  1
2008 Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D. The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proceedings of the National Academy of Sciences of the United States of America. 105: 8585-90. PMID 18562292 DOI: 10.1073/pnas.0803233105  1
2008 Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D. Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain. The Biochemical Journal. 415: 155-63. PMID 18498246 DOI: 10.1042/BJ20071708  1
2007 Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 130: 651-62. PMID 17719543 DOI: 10.1016/j.cell.2007.06.050  1
2007 Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM, Silverberg MS, Rotin D. Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. Current Biology : Cb. 17: 1212-8. PMID 17614280 DOI: 10.1016/j.cub.2007.06.013  1
2007 Lu C, Pribanic S, Debonneville A, Jiang C, Rotin D. The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic (Copenhagen, Denmark). 8: 1246-64. PMID 17605762 DOI: 10.1111/j.1600-0854.2007.00602.x  1
2007 Gupta R, Kus B, Fladd C, Wasmuth J, Tonikian R, Sidhu S, Krogan NJ, Parkinson J, Rotin D. Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Molecular Systems Biology. 3: 116. PMID 17551511 DOI: 10.1038/msb4100159  1
2007 Lu C, Jiang C, Pribanic S, Rotin D. CFTR stabilizes ENaC at the plasma membrane Journal of Cystic Fibrosis. 6: 419-422. PMID 17434346 DOI: 10.1016/j.jcf.2007.03.001  1
2007 Ing B, Shteiman-Kotler A, Castelli M, Henry P, Pak Y, Stewart B, Boulianne GL, Rotin D. Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Molecular and Cellular Biology. 27: 481-96. PMID 17074801 DOI: 10.1128/MCB.00463-06  1
2007 Siu R, Fladd C, Rotin D. N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Molecular and Cellular Biology. 27: 208-19. PMID 17060446 DOI: 10.1128/MCB.00707-06  1
2006 Pak Y, Glowacka WK, Bruce MC, Pham N, Rotin D. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. The Journal of Cell Biology. 175: 631-45. PMID 17116753 DOI: 10.1083/jcb.200603001  1
2006 Kirkham DL, Pacey LK, Axford MM, Siu R, Rotin D, Doering LC. Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture. Bmc Neuroscience. 7: 50. PMID 16784531 DOI: 10.1186/1471-2202-7-50  1
2006 Staub O, Rotin D. Role of ubiquitylation in cellular membrane transport. Physiological Reviews. 86: 669-707. PMID 16601271 DOI: 10.1152/physrev.00020.2005  1
2006 Kanelis V, Bruce MC, Skrynnikov NR, Rotin D, Forman-Kay JD. Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. Structure (London, England : 1993). 14: 543-53. PMID 16531238 DOI: 10.1016/j.str.2005.11.018  1
2006 Amsen EM, Pham N, Pak Y, Rotin D. The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells. The Journal of Biological Chemistry. 281: 121-8. PMID 16272156 DOI: 10.1074/jbc.M507595200  1
2005 Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, ... ... Rotin D, et al. Problems with co-funding in Canada. Science (New York, N.Y.). 308: 1867. PMID 15976286 DOI: 10.1126/science.308.5730.1867b  1
2005 Kus B, Gajadhar A, Stanger K, Cho R, Sun W, Rouleau N, Lee T, Chan D, Wolting C, Edwards A, Bosse R, Rotin D. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. The Journal of Biological Chemistry. 280: 29470-8. PMID 15955809 DOI: 10.1074/jbc.M502197200  1
2005 Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apothéloz F, Cordonier S, Staub O, Rotin D, Abriel H. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. American Journal of Physiology. Cell Physiology. 288: C692-701. PMID 15548568 DOI: 10.1152/ajpcell.00460.2004  1
2003 Ishikawa T, Jiang C, Stutts MJ, Marunaka Y, Rotin D. Regulation of the epithelial Na+ channel by cytosolic ATP. The Journal of Biological Chemistry. 278: 38276-86. PMID 12876281 DOI: 10.1074/jbc.M307216200  1
2003 Vecchione A, Marchese A, Henry P, Rotin D, Morrione A. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Molecular and Cellular Biology. 23: 3363-72. PMID 12697834 DOI: 10.1128/MCB.23.9.3363-3372.2003  1
2003 Henry PC, Kanelis V, O'Brien MC, Kim B, Gautschi I, Forman-Kay J, Schild L, Rotin D. Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel. The Journal of Biological Chemistry. 278: 20019-28. PMID 12654927 DOI: 10.1074/jbc.M211153200  1
2003 Batt J, Cutz E, Fladd C, Rotin D. Apparent normal lung architecture in protein tyrosine phosphatase-sigma-deficient mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L214-23. PMID 12471016 DOI: 10.1152/ajplung.00069.2002  1
2002 Pak Y, Pham N, Rotin D. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Molecular and Cellular Biology. 22: 7942-52. PMID 12391161 DOI: 10.1128/MCB.22.22.7942-7952.2002  1
2002 Meathrel K, Adamek T, Batt J, Rotin D, Doering LC. Protein tyrosine phosphatase sigma-deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system. Journal of Neuroscience Research. 70: 24-35. PMID 12237861 DOI: 10.1002/jnr.10382  1
2002 Myat A, Henry P, McCabe V, Flintoft L, Rotin D, Tear G. Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron. 35: 447-59. PMID 12165468 DOI: 10.1016/S0896-6273(02)00795-X  1
2002 McLean J, Batt J, Doering LC, Rotin D, Bain JR. Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in receptor protein tyrosine phosphatase sigma knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5481-91. PMID 12097500  1
2002 Ostenson CG, Sandberg-Nordqvist AC, Chen J, Hällbrink M, Rotin D, Langel U, Efendic S. Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochemical and Biophysical Research Communications. 291: 945-50. PMID 11866457 DOI: 10.1006/bbrc.2002.6536  1
2002 Batt J, Asa S, Fladd C, Rotin D. Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice. Molecular Endocrinology (Baltimore, Md.). 16: 155-69. PMID 11773446 DOI: 10.1210/mend.16.1.0756  1
2002 Hanwell D, Ishikawa T, Saleki R, Rotin D. Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 277: 9772-9. PMID 11773057 DOI: 10.1074/jbc.M110904200  1
2001 Pham N, Rotin D. Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF Journal of Biological Chemistry. 276: 46995-47003. PMID 11598133 DOI: 10.1074/jbc.M108373200  1
2001 Rotin D, Kanelis V, Schild L. Trafficking and cell surface stability of ENaC. American Journal of Physiology. Renal Physiology. 281: F391-9. PMID 11502587  1
2001 Kanelis V, Rotin D, Forman-Kay JD. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nature Structural Biology. 8: 407-12. PMID 11323714 DOI: 10.1038/87562  1
2000 Winberg G, Matskova L, Chen F, Plant P, Rotin D, Gish G, Ingham R, Ernberg I, Pawson T. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases Molecular and Cellular Biology. 20: 8526-8535. PMID 11046148 DOI: 10.1128/MCB.20.22.8526-8535.2000  1
2000 Rotin D. Regulation of the epithelial sodium channel (ENaC) by accessory proteins Current Opinion in Nephrology and Hypertension. 9: 529-534. PMID 10990373 DOI: 10.1097/00041552-200009000-00012  1
2000 Rotin D, Staub O, Haguenauer-Tsapis R. Ubiquitination and endocytosis of plasma membrane proteins: Role of Nedd4/Rsp5p family of ubiquitin-protein ligases Journal of Membrane Biology. 176: 1-17. PMID 10882424 DOI: 10.1007/s002320001079  1
2000 Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D. Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. The Journal of Cell Biology. 149: 1473-84. PMID 10871286 DOI: 10.1083/jcb.149.7.1473  1
2000 Kanelis V, Donaldson L, Muhandiram DR, Rotin D, Forman-Kay JD, Kay LE. Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes. Journal of Biomolecular Nmr. 16: 253-9. PMID 10805132 DOI: 10.1023/A:1008355012528  1
2000 Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Current Biology : Cb. 10: 555-8. PMID 10801446 DOI: 10.1016/S0960-9822(00)00473-5  1
2000 Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D. Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney International. 57: 809-15. PMID 10720933 DOI: 10.1046/j.1523-1755.2000.00919.x  1
1999 Morrione A, Plant P, Valentinis B, Staub O, Kumar S, Rotin D, Baserga R. mGrb10 interacts with Nedd4 Journal of Biological Chemistry. 274: 24094-24099. PMID 10446181 DOI: 10.1074/jbc.274.34.24094  1
1999 Chow CW, Woodside M, Demaurex N, Yu FH, Plant P, Rotin D, Grinstein S, Orlowski J. Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. The Journal of Biological Chemistry. 274: 10481-8. PMID 10187839 DOI: 10.1074/jbc.274.15.10481  1
1999 Wallace MJ, Batt J, Fladd CA, Henderson JT, Skarnes W, Rotin D. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ Nature Genetics. 21: 334-338. PMID 10080192 DOI: 10.1038/6866  1
1999 Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. The Journal of Clinical Investigation. 103: 667-73. PMID 10074483 DOI: 10.1172/JCI5713  1
1999 Staub O, Plant P, Ishikawa T, Schild L, Rotin D. Chapter 5 Regulation of ENaC by Interacting Proteins and by Ubiquitination Current Topics in Membranes and Transport. 47: 65-86. DOI: 10.1016/S0070-2161(08)60953-3  1
1998 Kanelis V, Farrow NA, Kay LE, Rotin D, Forman-Kay JD. NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 76: 341-50. PMID 9923703  1
1998 Liu J, Fitzli D, Liu M, Tseu I, Caniggia I, Rotin D, Post M. PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase American Journal of Physiology - Lung Cellular and Molecular Physiology. 274. PMID 9612285  1
1998 Ishikawa T, Marunaka Y, Rotin D. Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells: Effects of Na+ and Ca2+ Journal of General Physiology. 111: 825-846. PMID 9607939 DOI: 10.1085/jgp.111.6.825  1
1998 Wallace MJ, Fladd C, Batt J, Rotin D. The second catalytic domain of protein tyrosine phosphatase δ (PTPδ) binds to and inhibits the first catalytic domain of PTPσ Molecular and Cellular Biology. 18: 2608-2616. PMID 9566880  1
1997 Plant PJ, Yeger H, Staub O, Howard P, Rotin D. The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. The Journal of Biological Chemistry. 272: 32329-36. PMID 9405440 DOI: 10.1074/jbc.272.51.32329  1
1997 Rotin D. WW (WWP) domains: From structure to function Current Topics in Microbiology and Immunology. 228: 115-133. PMID 9401204  1
1997 Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination Embo Journal. 16: 6325-6336. PMID 9351815 DOI: 10.1093/emboj/16.21.6325  1
1997 Staub O, Rotin D. Regulation of ion transport by protein-protein interaction domains Current Opinion in Nephrology and Hypertension. 6: 447-454. PMID 9327203  1
1997 Staub O, Yeger H, Plant PJ, Kim H, Ernst SA, Rotin D. Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). The American Journal of Physiology. 272: C1871-80. PMID 9227416  1
1996 Kim H, Yeger H, Han R, Wallace M, Goldstein B, Rotin D. Expression of LAR-PTP2 in rat lung is confined to proliferating epithelia lining the airways and air sacs American Journal of Physiology - Lung Cellular and Molecular Physiology. 270. PMID 8928816  1
1996 Staub O, Rotin D. WW domains Structure. 4: 495-499. PMID 8736547  1
1996 Staub O, Dho S, Henry PC, Correa J, Ishikawa T, McGlade J, Rotin D. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome Embo Journal. 15: 2371-2380. PMID 8665844  1
1994 Fialkow L, Chan CK, Rotin D, Grinstein S, Downey GP. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils: Role of Oxidants Journal of Biological Chemistry. 269: 31234-31242. PMID 7983067  1
1994 Rotin D, Bar-Sagi D, O'Brodovich H, Merilainen J, Lehto VP, Canessa CM, Rossier BC, Downey GP. An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. The Embo Journal. 13: 4440-50. PMID 7925286  1
1994 Batzer AG, Rotin D, Ureña JM, Skolnik EY, Schlessinger J. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Molecular and Cellular Biology. 14: 5192-201. PMID 7518560  1
1994 Rotin D, Goldstein BJ, Fladd CA. Expression of the tyrosine phosphatase LAR-PTP2 is developmentally regulated in lung epithelia Am.J.Physiol.. 267.  1
1993 Bar-Sagi D, Rotin D, Batzer A, Mandiyan V, Schlessinger J. SH3 domains direct cellular localization of signaling molecules. Cell. 74: 83-91. PMID 8334708 DOI: 10.1016/0092-8674(93)90296-3  1
1992 Rotin D, Margolis B, Mohammadi M, Daly RJ, Daum G, Li N, Fischer EH, Burgess WH, Ullrich A, Schlessinger J. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. The Embo Journal. 11: 559-67. PMID 1537335  1
1992 Spivak-Kroizman T, Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I. Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. The Journal of Biological Chemistry. 267: 8056-63. PMID 1349015  1
1992 Grinstein S, Woodside M, Sardet C, Pouyssegur J, Rotin D. Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. The Journal of Biological Chemistry. 267: 23823-8. PMID 1331102  1
1992 Rotin D, Honegger AM, Margolis BL, Ullrich A, Schlessinger J. Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor. The Journal of Biological Chemistry. 267: 9678-83. PMID 1315766  1
1991 Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W, Dionne CA, Jaye M, Rubinstein M, Schlessinger J. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Molecular and Cellular Biology. 11: 5068-78. PMID 1656221  1
1989 Rotin D, Grinstein S. Impaired cell volume regulation in Na+-H+ exchange-deficient mutants American Journal of Physiology - Cell Physiology. 257. PMID 2558570  1
1989 Tannock IF, Rotin D. Acid pH in Tumors and Its Potential for Therapeutic Exploitation Cancer Research. 49: 4373-4384. PMID 2545340  1
1989 Grinstein S, Rotin D, Mason MJ. Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation Bba - Reviews On Biomembranes. 988: 73-97. PMID 2535787 DOI: 10.1016/0304-4157(89)90004-X  1
1989 Rotin D, Steele-Norwood D, Grinstein S, Tannock I. Requirement of the Na+/H+ Exchanger for Tumor Growth Cancer Research. 49: 205-211. PMID 2535690  1
1988 Tannock IF, Rotin D. Keynote Address: Mechanisms of interaction between radiation and drugs with potential for improvements in therapy Nci Monographs. 77-83. PMID 3352792  1
1987 Rotin D, Wan P, Grinstein S, Tannock I. Cytotoxicity of compounds that interfere with the regulation of intracellular ph: A potential new class of anticancer drugs Cancer Research. 47: 1497-1504. PMID 3815351  1
1986 Rotin D, Tannock IF, Robinson B. Influence of Hypoxia and an Acidic Environment on the Metabolism and Viability of Cultured Cells: Potential Implications for Cell Death in Tumors Cancer Research. 46: 2821-2826. PMID 3698008  1
1984 Rotin D, Tannock IF. The effect of the drug lonidamine on chinese hamster ovary cells in vitro and on experimental tumors International Journal of Radiation Oncology, Biology, Physics. 10: 1595-1598. PMID 6480446 DOI: 10.1016/0360-3016(84)90509-1  1
1983 Rotin D, Tobe SS. The possible role of juvenile hormone esterase in the regulation of juvenile hormone titre in the female cockroach Diploptera punctata Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire. 61: 811-817. PMID 6627093  1
1983 Sokolowski MB, Hansell RI, Rotin D. Drosophila larval foraging behavior. II. Selection in the sibling species, D. melanogaster and D. simulans. Behavior Genetics. 13: 169-77. PMID 6407462 DOI: 10.1007/BF01065665  1
1982 Szibbo CM, Rotin D, Feyereisen R, Tobe SS. Synthesis and degradation of C16 juvenile hormone (JH III) during the final two stadia of the cockroach, Diploptera punctata General and Comparative Endocrinology. 48: 25-32. PMID 7129084 DOI: 10.1016/0016-6480(82)90034-X  1
1982 Rotin D, Feyereisen R, Koener J, Tobe SS. Haemolymph juvenile hormone esterase activity during the reproductive cycle of the viviparous cockroach Diploptera punctata Insect Biochemistry. 12: 263-268. DOI: 10.1016/0020-1790(82)90084-1  1
Show low-probability matches.