| Year |
Citation |
Score |
| 2022 |
Shahpasand-Kroner H, Siddique I, Malik R, Linares G, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. Molecular tweezers - supramolecular hosts with broad-spectrum biological applications. Pharmacological Reviews. PMID 36549866 DOI: 10.1124/pharmrev.122.000654 |
0.308 |
|
| 2022 |
Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 30: 3499. PMID 36261045 DOI: 10.1016/j.ymthe.2022.10.001 |
0.302 |
|
| 2022 |
Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Correction for "Comparison of Three Amyloid Assembly Inhibitors: The Sugar -Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01". Acs Chemical Neuroscience. PMID 36001876 DOI: 10.1021/acschemneuro.2c00481 |
0.743 |
|
| 2021 |
Shahpasand-Kroner H, Portillo J, Lantz C, Seidler PM, Sarafian N, Loo JA, Bitan G. Three-repeat and four-repeat tau isoforms form different oligomers. Protein Science : a Publication of the Protein Society. PMID 34902187 DOI: 10.1002/pro.4257 |
0.363 |
|
| 2021 |
Murakami K, Izuo N, Bitan G. Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases. The Journal of Biological Chemistry. 298: 101478. PMID 34896392 DOI: 10.1016/j.jbc.2021.101478 |
0.486 |
|
| 2021 |
Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. Correction: Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone. The Biochemical Journal. 478: 4151. PMID 34871366 DOI: 10.1042/BJ20101391_COR |
0.545 |
|
| 2021 |
Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimer's Research & Therapy. 13: 83. PMID 33879220 DOI: 10.1186/s13195-021-00824-5 |
0.372 |
|
| 2021 |
Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's Research & Therapy. 13: 6. PMID 33397489 DOI: 10.1186/s13195-020-00743-x |
0.429 |
|
| 2020 |
Malik R, Corrales C, Linsenmeier M, Alalami H, Sepanj N, Bitan G. Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32701214 DOI: 10.1096/Fj.202000948R |
0.412 |
|
| 2020 |
Mason AJ, Hurst I, Malik R, Siddique I, Solomonov I, Sagi I, Klärner FG, Schrader T, Bitan G. Different inhibitors of Aβ42-induced toxicity have distinct metal-ion dependency. Acs Chemical Neuroscience. PMID 32559370 DOI: 10.1021/Acschemneuro.0C00192 |
0.517 |
|
| 2020 |
Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32087148 DOI: 10.1016/J.Ymthe.2020.02.005 |
0.518 |
|
| 2019 |
Shin WS, Di J, Murray KA, Sun C, Li B, Bitan G, Jiang L. Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. Frontiers in Molecular Neuroscience. 12: 268. PMID 31787880 DOI: 10.3389/Fnmol.2019.00268 |
0.516 |
|
| 2019 |
Hadrovic I, Rebmann P, Klärner FG, Bitan G, Schrader T. Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Frontiers in Chemistry. 7: 657. PMID 31632951 DOI: 10.3389/Fchem.2019.00657 |
0.461 |
|
| 2019 |
Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimer's Research & Therapy. 11: 86. PMID 31627745 DOI: 10.1186/S13195-019-0541-9 |
0.494 |
|
| 2019 |
Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathologica Communications. 7: 135. PMID 31429800 DOI: 10.1186/S40478-019-0783-6 |
0.689 |
|
| 2019 |
Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31319154 DOI: 10.1016/J.Bbadis.2019.07.007 |
0.396 |
|
| 2019 |
Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, ... ... Bitan G, et al. Major differences between the self-assembly and seeding behavior of heparin-induced- and in-vitro-phosphorylated tau and their modulation by potential inhibitors. Acs Chemical Biology. PMID 31046227 DOI: 10.1021/Acschembio.9B00325 |
0.442 |
|
| 2019 |
Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. The Journal of Biological Chemistry. PMID 30602569 DOI: 10.1074/Jbc.Ra118.005940 |
0.426 |
|
| 2019 |
Shin WS, Bitan G, Jiang L. F2-06-03: AMYLOID β-PROTEIN OLIGOMERS PROMOTE THE UPTAKE OF TAU FIBRIL SEEDS POTENTIATING INTRACELLULAR TAU AGGREGATION Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4438 |
0.453 |
|
| 2019 |
Di J, Li Z, Siddique I, Ericsson I, Boghos A, Wang A, Meng H, Malki G, Schrader T, Klärner F, Bitan G. THE MOLECULAR TWEEZER CLR01 AMELIORATES PATHOLOGY IN THE P301S-TAU MOUSE MODEL Alzheimer's & Dementia. 15: P236-P237. DOI: 10.1016/J.Jalz.2019.06.041 |
0.333 |
|
| 2018 |
Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA. Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. Journal of the American Society For Mass Spectrometry. PMID 30062477 DOI: 10.1007/S13361-018-2027-6 |
0.397 |
|
| 2018 |
Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size. Methods in Molecular Biology (Clifton, N.J.). 1779: 3-12. PMID 29886523 DOI: 10.1007/978-1-4939-7816-8_1 |
0.812 |
|
| 2018 |
Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins. Methods in Molecular Biology (Clifton, N.J.). 1777: 369-386. PMID 29744849 DOI: 10.1007/978-1-4939-7811-3_24 |
0.625 |
|
| 2017 |
Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J. Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. Journal of the American Heart Association. 6. PMID 28862927 DOI: 10.1161/Jaha.117.006182 |
0.48 |
|
| 2017 |
Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G. A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28585223 DOI: 10.1007/S13311-017-0544-9 |
0.686 |
|
| 2017 |
Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, et al. Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01. Journal of the American Chemical Society. PMID 28406616 DOI: 10.1021/Jacs.6B11039 |
0.753 |
|
| 2016 |
Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB. Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes. Analytical Biochemistry. PMID 27810329 DOI: 10.1016/J.Ab.2016.10.026 |
0.815 |
|
| 2016 |
Schrader T, Bitan G, Klärner FG. Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation. Chemical Communications (Cambridge, England). PMID 27546596 DOI: 10.1039/C6Cc04640A |
0.468 |
|
| 2016 |
Li H, Rahimi F, Bitan G. Modulation of amyloid β-protein (Aβ) assembly by homologous C-terminal fragments as a strategy for inhibiting Aβ toxicity. Acs Chemical Neuroscience. PMID 27322435 DOI: 10.1021/Acschemneuro.6B00154 |
0.778 |
|
| 2016 |
Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson's Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environmental Health Perspectives. PMID 27301718 DOI: 10.1289/Ehp141 |
0.349 |
|
| 2015 |
Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT. Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity? The Journal of Physical Chemistry. B. PMID 26439281 DOI: 10.1021/Acs.Jpcb.5B08177 |
0.694 |
|
| 2015 |
Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB. Role of species-specific primary structure differences in Aβ42 assembly and neurotoxicity. Acs Chemical Neuroscience. PMID 26421877 DOI: 10.1021/Acschemneuro.5B00180 |
0.749 |
|
| 2015 |
Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R. Toxicity Inhibitors Protect Lipid Membranes from Disruption by Aβ42. Acs Chemical Neuroscience. PMID 26317327 DOI: 10.1021/Acschemneuro.5B00200 |
0.456 |
|
| 2015 |
Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Bitan G, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 4. PMID 26284498 DOI: 10.7554/Elife.05397 |
0.328 |
|
| 2015 |
Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D. The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. Biochemistry. 54: 3729-38. PMID 26030124 DOI: 10.1021/Bi501092P |
0.463 |
|
| 2015 |
Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G. Molecular Tweezers Inhibit Islet Amyloid Polypeptide Assembly and Toxicity by a New Mechanism. Acs Chemical Biology. 10: 1555-69. PMID 25844890 DOI: 10.1021/Acschembio.5B00146 |
0.809 |
|
| 2015 |
Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT. Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03. The Journal of Physical Chemistry. B. 119: 4831-41. PMID 25751170 DOI: 10.1021/Acs.Jpcb.5B00692 |
0.517 |
|
| 2014 |
Attar A, Chan WT, Klärner FG, Schrader T, Bitan G. Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity. Bmc Pharmacology & Toxicology. 15: 23. PMID 24735982 DOI: 10.1186/2050-6511-15-23 |
0.617 |
|
| 2014 |
Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. Molecular basis for preventing α-synuclein aggregation by a molecular tweezer. The Journal of Biological Chemistry. 289: 10727-37. PMID 24567327 DOI: 10.1074/Jbc.M113.524520 |
0.622 |
|
| 2014 |
Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. Molecular tweezers targeting transthyretin amyloidosis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 450-61. PMID 24459092 DOI: 10.1007/S13311-013-0256-8 |
0.664 |
|
| 2014 |
Attar A, Bitan G. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models. Current Pharmaceutical Design. 20: 2469-83. PMID 23859557 DOI: 10.2174/13816128113199990496 |
0.655 |
|
| 2014 |
Rahimi F, Bitan G. Overview of fibrillar and oligomeric assemblies of amyloidogenic proteins Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. 2147483647: 1-36. DOI: 10.1007/978-94-007-2774-8_1 |
0.559 |
|
| 2014 |
Rahimi F, Bitan G. Preface Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. 2147483647: v-vi. DOI: 10.1007/978-94-007-2774-8 |
0.378 |
|
| 2013 |
Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. Plos One. 8: e80355. PMID 24236177 DOI: 10.1371/Journal.Pone.0080355 |
0.533 |
|
| 2013 |
Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C. Tranilast binds to aβ monomers and promotes aβ fibrillation. Biochemistry. 52: 3995-4002. PMID 23679559 DOI: 10.1021/Bi400426T |
0.797 |
|
| 2013 |
Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C. Effects of different amyloid β-protein analogues on synaptic function. Neurobiology of Aging. 34: 1032-44. PMID 23046860 DOI: 10.1016/J.Neurobiolaging.2012.06.027 |
0.345 |
|
| 2013 |
Attar A, Rahimi F, Bitan G. Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01 Translational Neuroscience. 4: 385-409. DOI: 10.2478/S13380-013-0137-Y |
0.767 |
|
| 2013 |
Attar A, Meral D, Urbanc B, Bitan G. Assembly of Amyloid β-Protein Variants Containing Familial Alzheimer's Disease-Linked Amino Acid Substitutions Bio-Nanoimaging: Protein Misfolding and Aggregation. 429-442. DOI: 10.1016/B978-0-12-394431-3.00038-9 |
0.605 |
|
| 2012 |
Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, ... ... Bitan G, et al. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain : a Journal of Neurology. 135: 3735-48. PMID 23183235 DOI: 10.1093/Brain/Aws289 |
0.753 |
|
| 2012 |
Sinha S, Lopes DH, Bitan G. A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity. Acs Chemical Neuroscience. 3: 473-81. PMID 22860216 DOI: 10.1021/Cn3000247 |
0.838 |
|
| 2012 |
Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G. Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. Acs Chemical Neuroscience. 3: 451-8. PMID 22860214 DOI: 10.1021/Cn200133X |
0.778 |
|
| 2012 |
Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I. Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons. The Journal of Biological Chemistry. 287: 20555-64. PMID 22528492 DOI: 10.1074/Jbc.M112.344036 |
0.704 |
|
| 2012 |
Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB. Preparation of stable amyloid β-protein oligomers of defined assembly order. Methods in Molecular Biology (Clifton, N.J.). 849: 23-31. PMID 22528081 DOI: 10.1007/978-1-61779-551-0_3 |
0.719 |
|
| 2012 |
Lopes DH, Sinha S, Rosensweig C, Bitan G. Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins. Methods in Molecular Biology (Clifton, N.J.). 849: 11-21. PMID 22528080 DOI: 10.1007/978-1-61779-551-0_2 |
0.827 |
|
| 2012 |
Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. Design of β-amyloid aggregation inhibitors from a predicted structural motif. Journal of Medicinal Chemistry. 55: 3002-10. PMID 22420626 DOI: 10.1021/Jm201332P |
0.805 |
|
| 2012 |
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 464-76. PMID 22373667 DOI: 10.1007/S13311-012-0105-1 |
0.769 |
|
| 2012 |
Liu T, Bitan G. Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms. Chemmedchem. 7: 359-74. PMID 22323134 DOI: 10.1002/Cmdc.201100585 |
0.452 |
|
| 2012 |
Li H, Zemel R, Lopes DH, Monien BH, Bitan G. A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors. Chemmedchem. 7: 515-22. PMID 22307963 DOI: 10.1002/Cmdc.201100584 |
0.79 |
|
| 2012 |
Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT. Aβ(39-42) modulates Aβ oligomerization but not fibril formation. Biochemistry. 51: 108-17. PMID 22129303 DOI: 10.1021/Bi201520B |
0.649 |
|
| 2012 |
Bitan G. Can We Accelerate the Path towards Therapy for Amyloid-Related Diseases? Journal of Gerontology & Geriatric Research. 1. DOI: 10.4172/2167-7182.1000E106 |
0.314 |
|
| 2012 |
Attar A, Ripoli C, Riccardi E, Maiti P, Liu T, Jones M, Yang F, Tseng C, Klärner F, Schrader T, Frautschy S, Grassi C, Bitan G. O2-12-01: Lysine-specific molecular tweezers protect neurons against beta-amyloid-induced synaptotoxicity and lower beta-amyloid and p-tau load in a mouse model of Alzheimer's disease Alzheimer's & Dementia. 8: P259-P259. DOI: 10.1016/J.Jalz.2012.05.690 |
0.633 |
|
| 2012 |
Bitan G, Sinha S, Lopes D, Du Z, Maiti P, Klärner F, Schrader T, Wang C. P4-051: Structural insight into the mechanism of beta-amyloid toxicity and its inhibition by small molecules Alzheimer's & Dementia. 8: P653-P653. DOI: 10.1016/J.Jalz.2012.05.1753 |
0.798 |
|
| 2012 |
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner F, Schrader T, Stahl M, Bitan G, Bronstein JM. Erratum to: A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity In Vitro and In Vivo Neurotherapeutics. 9: 486-486. DOI: 10.1007/S13311-012-0120-2 |
0.698 |
|
| 2011 |
Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G. C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42. Journal of Medicinal Chemistry. 54: 8451-60. PMID 22087474 DOI: 10.1021/Jm200982P |
0.818 |
|
| 2011 |
Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G. Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry. 50: 10687-97. PMID 22059533 DOI: 10.1021/Bi201426B |
0.818 |
|
| 2011 |
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, ... ... Bitan G, et al. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. Journal of the American Chemical Society. 133: 16958-69. PMID 21916458 DOI: 10.1021/Ja206279B |
0.825 |
|
| 2011 |
Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G. Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study. Journal of Molecular Biology. 410: 316-28. PMID 21621545 DOI: 10.1016/J.Jmb.2011.05.021 |
0.724 |
|
| 2011 |
Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T. Rational design of β-sheet ligands against Aβ42-induced toxicity. Journal of the American Chemical Society. 133: 4348-58. PMID 21381732 DOI: 10.1021/Ja107675N |
0.686 |
|
| 2011 |
Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G. Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone. The Biochemical Journal. 433: 323-32. PMID 21044048 DOI: 10.1042/Bj20101391 |
0.604 |
|
| 2011 |
Ripoli C, Riccardi E, Piacentini R, Bitan G, Grassi C. S7.4 Effects of different forms of amyloid β-peptide on synaptic function Clinical Neurophysiology. 122: S19. DOI: 10.1016/S1388-2457(11)60062-X |
0.394 |
|
| 2011 |
Lopes D, Sinha S, Bitan G. A key role for lysine residues in amyloid-β protein folding, assembly, and toxicity Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1349 |
0.816 |
|
| 2011 |
Urbanc B, Barz B, Betnel M, Cruz L, Bitan G, Teplow DB. Structural Basis for Amyloid β-Protein Toxicity Inhibition: A Multiscale Computational Study Biophysical Journal. 100: 390a. DOI: 10.1016/J.Bpj.2010.12.2317 |
0.68 |
|
| 2010 |
Rahimi F, Bitan G. Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. Journal of Visualized Experiments : Jove. PMID 20616783 DOI: 10.3791/1955 |
0.687 |
|
| 2010 |
Li H, Monien BH, Lomakin A, Zemel R, Fradinger EA, Tan M, Spring SM, Urbanc B, Xie CW, Benedek GB, Bitan G. Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments. Biochemistry. 49: 6358-64. PMID 20568734 DOI: 10.1021/Bi100773G |
0.793 |
|
| 2010 |
Maiti P, Lomakin A, Benedek GB, Bitan G. Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity. Journal of Neurochemistry. 113: 1252-62. PMID 20345758 DOI: 10.1111/J.1471-4159.2010.06692.X |
0.551 |
|
| 2010 |
Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB. Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study. Journal of the American Chemical Society. 132: 4266-80. PMID 20218566 DOI: 10.1021/Ja9096303 |
0.672 |
|
| 2010 |
Li H, Monien BH, Fradinger EA, Urbanc B, Bitan G. Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity. Biochemistry. 49: 1259-67. PMID 20050679 DOI: 10.1021/Bi902075H |
0.807 |
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| 2010 |
Attar A, Sinha S, Maiti P, Yang F, Gant D, Jones M, Talbiersky P, Schrader T, Klärner F, Frautschy S, Bitan G. P4-100: Small Molecule Inhibitor of Amyloid beta-protein Oligomerization Reduces Brain Abeta Load in an Alzheimer's Disease Mouse Model Alzheimer's & Dementia. 6: e51-e51. DOI: 10.1016/J.Jalz.2010.08.158 |
0.802 |
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| 2010 |
Bitan G, Sinha S, Attar A, Maiti P, Tan M, Prabhudesai S, Talbiersky P, Bakshi R, Kuo P, Yang F, Gant D, Jones MR, Xie C, Bronstein JM, Frautschy SA, et al. O3-07-02: Novel, small molecule inhibitors of protein aggregation for treatment of amyloid-related diseases Alzheimer's & Dementia. 6: S142-S142. DOI: 10.1016/J.Jalz.2010.05.436 |
0.789 |
|
| 2010 |
Maiti P, Moskovitz J, Piacentini R, Ripoli C, Lomakin A, Grassi C, Benedek GB, Bitan G. P2-269: Aβ-sulfoxide but not Aβ-sulfone reduces neurotoxicity through the methionine sulfoxide reductase system Alzheimer's & Dementia. 6: S393-S393. DOI: 10.1016/J.Jalz.2010.05.1319 |
0.602 |
|
| 2009 |
Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT. Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nature Chemistry. 1: 326-31. PMID 20703363 DOI: 10.1038/Nchem.247 |
0.673 |
|
| 2009 |
Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G. RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. Plos One. 4: e7694. PMID 19901993 DOI: 10.1371/Journal.Pone.0007694 |
0.74 |
|
| 2009 |
Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. Amino acid position-specific contributions to amyloid beta-protein oligomerization. The Journal of Biological Chemistry. 284: 23580-91. PMID 19567875 DOI: 10.1074/Jbc.M109.038133 |
0.836 |
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| 2009 |
Wu C, Murray MM, Bernstein SL, Condron MM, Bitan G, Shea JE, Bowers MT. The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study. Journal of Molecular Biology. 387: 492-501. PMID 19356595 DOI: 10.1016/J.Jmb.2009.01.029 |
0.457 |
|
| 2009 |
Rahimi F, Maiti P, Bitan G. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. Journal of Visualized Experiments : Jove. PMID 19229175 DOI: 10.3791/1071 |
0.715 |
|
| 2009 |
Urbanc B, Bitan G, Cruz L, Lam A, Teplow D. Computational Study of Assembly and Toxicity Inhibition of Amyloid Beta-Protein and Its Arctic Mutant Biophysical Journal. 96: 219a. DOI: 10.1016/J.Bpj.2008.12.1913 |
0.648 |
|
| 2008 |
Condron MM, Monien BH, Bitan G. Synthesis and Purification of Highly Hydrophobic Peptides Derived from the C-Terminus of Amyloid β-Protein. The Open Biotechnology Journal. 2: 87-93. PMID 19898686 DOI: 10.2174/1874070700802010087 |
0.707 |
|
| 2008 |
Fradinger EA, Monien BH, Urbanc B, Lomakin A, Tan M, Li H, Spring SM, Condron MM, Cruz L, Xie CW, Benedek GB, Bitan G. C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 14175-80. PMID 18779585 DOI: 10.1073/Pnas.0807163105 |
0.786 |
|
| 2008 |
Rahimi F, Shanmugam A, Bitan G. Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Current Alzheimer Research. 5: 319-41. PMID 18537546 DOI: 10.2174/156720508784533358 |
0.768 |
|
| 2008 |
Lazo ND, Maji SK, Fradinger EA, Bitan G, Teplow DB. The Amyloid β Protein Amyloid Proteins: the Beta Sheet Conformation and Disease. 2: 384-491. DOI: 10.1002/9783527619344.ch17 |
0.692 |
|
| 2007 |
Yun S, Urbanc B, Cruz L, Bitan G, Teplow DB, Stanley HE. Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study. Biophysical Journal. 92: 4064-77. PMID 17307823 DOI: 10.1529/Biophysj.106.097766 |
0.567 |
|
| 2007 |
Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiology of Aging. 28: 813-23. PMID 16725229 DOI: 10.1016/J.Neurobiolaging.2006.04.007 |
0.399 |
|
| 2006 |
Bitan G. Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins. Methods in Enzymology. 413: 217-36. PMID 17046399 DOI: 10.1016/S0076-6879(06)13012-8 |
0.495 |
|
| 2006 |
Monien BH, Apostolova LG, Bitan G. Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there? Expert Review of Neurotherapeutics. 6: 1293-306. PMID 17009917 DOI: 10.1586/14737175.6.9.1293 |
0.675 |
|
| 2006 |
Teplow DB, Lazo ND, Bitan G, Bernstein S, Wyttenbach T, Bowers MT, Baumketner A, Shea JE, Urbanc B, Cruz L, Borreguero J, Stanley HE. Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach. Accounts of Chemical Research. 39: 635-45. PMID 16981680 DOI: 10.1021/Ar050063S |
0.671 |
|
| 2006 |
Baumketner A, Bernstein SL, Wyttenbach T, Bitan G, Teplow DB, Bowers MT, Shea JE. Amyloid beta-protein monomer structure: a computational and experimental study. Protein Science : a Publication of the Protein Society. 15: 420-8. PMID 16501222 DOI: 10.1110/Ps.051762406 |
0.623 |
|
| 2005 |
Fradinger EA, Bitan G. En route to early diagnosis of Alzheimer's disease--are we there yet? Trends in Biotechnology. 23: 531-3. PMID 16165236 DOI: 10.1016/J.Tibtech.2005.09.002 |
0.435 |
|
| 2005 |
Bitan G, Fradinger EA, Spring SM, Teplow DB. Neurotoxic protein oligomers--what you see is not always what you get. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 88-95. PMID 16011984 DOI: 10.1080/13506120500106958 |
0.677 |
|
| 2005 |
Vollers SS, Teplow DB, Bitan G. Determination of Peptide oligomerization state using rapid photochemical crosslinking. Methods in Molecular Biology (Clifton, N.J.). 299: 11-8. PMID 15980592 DOI: 10.1385/1-59259-874-9:011 |
0.682 |
|
| 2005 |
Bitan G, Teplow DB. Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays. Methods in Molecular Biology (Clifton, N.J.). 299: 3-9. PMID 15980591 DOI: 10.1385/1-59259-874-9:003 |
0.689 |
|
| 2005 |
Bernstein SL, Wyttenbach T, Baumketner A, Shea JE, Bitan G, Teplow DB, Bowers MT. Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform. Journal of the American Chemical Society. 127: 2075-84. PMID 15713083 DOI: 10.1021/Ja044531P |
0.675 |
|
| 2004 |
Urbanc B, Cruz L, Yun S, Buldyrev SV, Bitan G, Teplow DB, Stanley HE. In silico study of amyloid beta-protein folding and oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 101: 17345-50. PMID 15583128 DOI: 10.1073/Pnas.0408153101 |
0.675 |
|
| 2004 |
Bitan G, Teplow DB. Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies. Accounts of Chemical Research. 37: 357-64. PMID 15196045 DOI: 10.1021/Ar000214L |
0.693 |
|
| 2004 |
Maji S, Bitan G, Vollers SS, Spring S, Condron MM, Teplow DB. P1-236 Site-specific analysis of Abeta oligomerization using photochemical cross-linking Neurobiology of Aging. 25: S163. DOI: 10.1016/S0197-4580(04)80549-9 |
0.685 |
|
| 2003 |
Bitan G, Tarus B, Vollers SS, Lashuel HA, Condron MM, Straub JE, Teplow DB. A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization. Journal of the American Chemical Society. 125: 15359-65. PMID 14664580 DOI: 10.1021/Ja0349296 |
0.68 |
|
| 2003 |
Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/Jci18104 |
0.446 |
|
| 2003 |
Bitan G, Vollers SS, Teplow DB. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. The Journal of Biological Chemistry. 278: 34882-9. PMID 12840029 DOI: 10.1074/Jbc.M300825200 |
0.612 |
|
| 2003 |
Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB. Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways. Proceedings of the National Academy of Sciences of the United States of America. 100: 330-5. PMID 12506200 DOI: 10.1073/Pnas.222681699 |
0.684 |
|
| 2002 |
Sun B, Fan W, Balciunas A, Cooper JK, Bitan G, Steavenson S, Denis PE, Young Y, Adler B, Daugherty L, Manoukian R, Elliott G, Shen W, Talvenheimo J, Teplow DB, et al. Polyglutamine repeat length-dependent proteolysis of huntingtin. Neurobiology of Disease. 11: 111-22. PMID 12460551 DOI: 10.1006/Nbdi.2002.0539 |
0.562 |
|
| 2002 |
Kirkitadze MD, Bitan G, Teplow DB. Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies. Journal of Neuroscience Research. 69: 567-77. PMID 12210822 DOI: 10.1002/Jnr.10328 |
0.685 |
|
| 2001 |
Scheibler L, Mierke DF, Bitan G, Rosenblatt M, Chorev M. Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry. 40: 15117-26. PMID 11735394 DOI: 10.1021/Bi0109156 |
0.322 |
|
| 2001 |
Bitan G, Lomakin A, Teplow DB. Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. The Journal of Biological Chemistry. 276: 35176-84. PMID 11441003 DOI: 10.1074/Jbc.M102223200 |
0.692 |
|
| 1998 |
Kasher R, Bitan G, Halloun C, Gilon C. Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38 Letters in Peptide Science. 5: 101-103. DOI: 10.1007/Bf02443447 |
0.494 |
|
| 1997 |
Muller D, Zeltser I, Bitan G, Gilon C. Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids. The Journal of Organic Chemistry. 62: 411-416. PMID 11671417 DOI: 10.1021/Jo961580E |
0.516 |
|
| 1997 |
Bitan G, Sukhotinsky I, Mashriki Y, Hanani M, Selinger Z, Gilon C. Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges. The Journal of Peptide Research : Official Journal of the American Peptide Society. 49: 421-6. PMID 9211223 DOI: 10.1111/J.1399-3011.1997.Tb00894.X |
0.505 |
|
| 1997 |
Bitan G, Muller D, Kasher R, Gluhov EV, Gilon C. Building units for N-backbone cyclic peptides. Part 4. Synthesis of protected Nα-functionalized alkyl amino acids by reductive alkylation of natural amino acids Journal of the Chemical Society - Perkin Transactions 1. 1501-1510. DOI: 10.1039/A608389G |
0.547 |
|
| 1997 |
Muller D, Zeltser I, Bitan G, Gilon C. Building units for N-backbone cyclic peptides. 3. Synthesis of protected N(α)-(ω-aminoalkyl)amino acids and N(α)-(ω-carboxyalkyl)amino acids Journal of Organic Chemistry. 62: 411-416. DOI: 10.1021/jo961580e |
0.48 |
|
| 1996 |
Bitan G, Zeltser I, Byk G, Halle D, Mashriki Y, Gluhov EV, Sukhotinsky I, Hanani M, Selinger Z, Gilon C. Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulphur in position 11. Journal of Peptide Science : An Official Publication of the European Peptide Society. 2: 261-9. PMID 9231334 DOI: 10.1002/Psc.76 |
0.671 |
|
| 1996 |
Behrens S, Mathä B, Bitan G, Gilon C, Kessler H. Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P. NMR and molecular dynamics. International Journal of Peptide and Protein Research. 48: 569-79. PMID 8985790 DOI: 10.1111/J.1399-3011.1996.Tb00876.X |
0.482 |
|
| 1996 |
Byk G, Halle D, Zeltser I, Bitan G, Selinger Z, Gilon C. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. Journal of Medicinal Chemistry. 39: 3174-8. PMID 8759639 DOI: 10.1021/Jm960154I |
0.704 |
|
| 1995 |
Bitan G, Behrens S, Mathä B, Mashriki Y, Hanani M, Kessler H, Gilon C. New backbone cyclic substance P analogs Letters in Peptide Science. 2: 121-124. DOI: 10.1007/Bf00119137 |
0.496 |
|
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