Jun-Lin Guan - Publications

Affiliations: 
1991-2006 Cornell University, Ithaca, NY, United States 
 2006-2014 Cell and Developmental Biology University of Michigan Medical School, Ann Arbor, MI, United States 
 2014- University of Cincinnati College of Medicine, Cincinnati, OH, United States 
Area:
Cell Biology, Biochemistry
Website:
https://med.uc.edu/cancerbiology/about/chair

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Gao C, Chen G, Zhang DH, Zhang J, Kuan SF, Hu W, Esni F, Gao X, Guan JL, Chu E, Hu J. PYK2 is involved in premalignant acinar cell reprogramming and pancreatic ductal adenocarcinoma maintenance by phosphorylating β-catenin. Cellular and Molecular Gastroenterology and Hepatology. PMID 31330317 DOI: 10.1016/j.jcmgh.2019.07.004  0.4
2019 Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez Y, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, et al. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription. Circulation Research. PMID 31096851 DOI: 10.1161/CIRCRESAHA.118.314344  1
2019 Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, ... ... Guan JL, et al. Histone H3 trimethylation at lysine 36 guides mA RNA modification co-transcriptionally. Nature. PMID 30867593 DOI: 10.1038/s41586-019-1016-7  1
2019 Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. PMID 30669939 DOI: 10.1080/15548627.2019.1569441  1
2018 Liu B, Du R, Zhou L, Xu J, Chen S, Chen J, Yang X, Liu DX, Shao ZM, Zhang L, Yu Z, Xie N, Guan JL, Liu S. miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/β-Catenin Axis. Theranostics. 8: 5801-5813. PMID 30613263 DOI: 10.7150/thno.29380  1
2018 Chen Q, Jin C, Shao X, Guan R, Tian Z, Wang C, Liu F, Ling P, Guan JL, Ji L, Wang F, Chao H, Diao J. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore. Small (Weinheim An Der Bergstrasse, Germany). 14: e1802166. PMID 30350549 DOI: 10.1002/smll.201802166  1
2018 Yeo SK, Paul R, Haas M, Wang C, Guan JL. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy. PMID 29938573 DOI: 10.1080/15548627.2018.1460010  1
2018 Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, ... Guan JL, et al. Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination. Cellular Microbiology. e12846. PMID 29582580 DOI: 10.1111/cmi.12846  1
2017 Xia H, Wang W, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Science Immunology. 2. PMID 29150439 DOI: 10.1126/sciimmunol.aan4631  1
2017 Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M. The Autophagy-Inducing Kinases, ULK1 and ULK2, Regulate Axon Guidance in the Developing Mouse Forebrain via a Noncanonical Pathway. Autophagy. 0. PMID 29099309 DOI: 10.1080/15548627.2017.1386820  1
2017 Wang C, Yeo S, Haas MA, Guan JL. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of Cell Biology. PMID 28634261 DOI: 10.1083/jcb.201609093  1
2016 Yeo SK, Guan JL. Hierarchical heterogeneity in mammary tumors and its regulation by autophagy. Autophagy. 1-2. PMID 27624535 DOI: 10.1080/15548627.2016.1213928  1
2016 Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW, Apte RS. Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease. Autophagy. 0. PMID 27463423 DOI: 10.1080/15548627.2016.1207857  1
2016 Yeo SK, Wen J, Chen S, Guan JL. Autophagy differentially regulates distinct breast cancer stem-like cells in murine models via EGFR/Stat3 and Tgfß/Smad signaling. Cancer Research. PMID 27197172 DOI: 10.1158/0008-5472.CAN-15-2946  1
2016 Sun S, Guan JL. Modeling lymphangiosarcoma in mice. Cell Cycle (Georgetown, Tex.). 0. PMID 27105012 DOI: 10.1080/15384101.2016.1176414  1
2016 Wagener BM, Hu M, Zheng A, Zhao X, Che P, Brandon A, Anjum N, Snapper S, Creighton J, Guan JL, Han Q, Cai GQ, Han X, Pittet JF, Ding Q. Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27025963 DOI: 10.1096/fj.201600102R  1
2016 Chen S, Wang C, Yeo S, Liang CC, Okamoto T, Sun S, Wen J, Guan JL. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes & Development. PMID 27013233 DOI: 10.1101/gad.276428.115  1
2016 Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL. Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of Cell Biology. PMID 27002165 DOI: 10.1083/jcb.20150702303082016c  1
2016 Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of Cell Biology. 212: 545-60. PMID 26929451 DOI: 10.1083/jcb.201507023  1
2015 Sun S, Chen S, Liu F, Wu H, McHugh J, Bergin IL, Gupta A, Adams D, Guan JL. Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. Cancer Cell. PMID 26777415 DOI: 10.1016/j.ccell.2015.10.004  1
2015 Tai YL, Chu PY, Lai IR, Wang MY, Tseng HY, Guan JL, Liou JY, Shen TL. An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer. Scientific Reports. 5: 16408. PMID 26549523 DOI: 10.1038/srep16408  1
2015 Wei H, Guan JL. Blocking tumor growth by targeting autophagy and SQSTM1 in vivo. Autophagy. 11: 854-5. PMID 26020424 DOI: 10.1080/15548627.2015.1048173  1
2015 Fang F, Sun S, Wang L, Guan JL, Giovannini M, Zhu Y, Liu F. Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 30: 1195-205. PMID 25639352 DOI: 10.1002/jbmr.2447  1
2015 Wen J, Yeo S, Wang C, Chen S, Sun S, Haas MA, Tu W, Jin F, Guan JL. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast Cancer Research and Treatment. 149: 619-29. PMID 25638397 DOI: 10.1007/s10549-015-3283-9  1
2015 Hsieh YH, van der Heyde H, Oh ES, Guan JL, Chang PL. Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis. Molecular Carcinogenesis. 54: 379-92. PMID 24249517 DOI: 10.1002/mc.22108  1
2014 Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. Elife. 3. PMID 25535838 DOI: 10.7554/eLife.05151  1
2014 Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. The Journal of Biological Chemistry. 289: 31001-13. PMID 25237194 DOI: 10.1074/jbc.M114.580811  1
2014 Wei H, Wang C, Croce CM, Guan JL. p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Genes & Development. 28: 1204-16. PMID 24888590 DOI: 10.1101/gad.237354.113  1
2014 Chen Y, Wei H, Liu F, Guan JL. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. The Journal of Biological Chemistry. 289: 1164-73. PMID 24275666 DOI: 10.1074/jbc.M113.526335  1
2013 Seong J, Tajik A, Sun J, Guan JL, Humphries MJ, Craig SE, Shekaran A, García AJ, Lu S, Lin MZ, Wang N, Wang Y. Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 19372-7. PMID 24222685 DOI: 10.1073/pnas.1307405110  1
2013 Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The Embo Journal. 32: 3130-44. PMID 24185898 DOI: 10.1038/emboj.2013.233  1
2013 Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Iwai K, Tokunaga F, Saito K, et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. The Journal of Cell Biology. 203: 115-28. PMID 24100292 DOI: 10.1083/jcb.201304188  1
2013 Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X. Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Molecular and Cellular Biology. 33: 4181-97. PMID 23979594 DOI: 10.1128/MCB.00650-13  1
2013 Ma D, Molusky MM, Song J, Hu CR, Fang F, Rui C, Mathew AV, Pennathur S, Liu F, Cheng JX, Guan JL, Lin JD. Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD. Molecular Endocrinology (Baltimore, Md.). 27: 1643-54. PMID 23960084 DOI: 10.1210/me.2013-1153  1
2013 Luo M, Zhao X, Chen S, Liu S, Wicha MS, Guan JL. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Research. 73: 5591-602. PMID 23832665 DOI: 10.1158/0008-5472.CAN-13-1351  1
2013 Kim M, Park HL, Park HW, Ro SH, Nam SG, Reed JM, Guan JL, Lee JH. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy. 9: 1201-13. PMID 23819996 DOI: 10.4161/auto.24811  1
2013 Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D. Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L291-300. PMID 23771883 DOI: 10.1152/ajplung.00094.2013  1
2013 Liu F, Fang F, Yuan H, Yang D, Chen Y, Williams L, Goldstein SA, Krebsbach PH, Guan JL. Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 2414-30. PMID 23633228 DOI: 10.1002/jbmr.1971  1
2013 Wang C, Liang CC, Bian ZC, Zhu Y, Guan JL. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nature Neuroscience. 16: 532-42. PMID 23542691 DOI: 10.1038/nn.3365  1
2013 Guan JL, Simon AK, Prescott M, Menendez JA, Liu F, Wang F, Wang C, Wolvetang E, Vazquez-Martin A, Zhang J. Autophagy in stem cells. Autophagy. 9: 830-49. PMID 23486312 DOI: 10.4161/auto.24132  1
2013 Ritt M, Guan JL, Sivaramakrishnan S. Visualizing and manipulating focal adhesion kinase regulation in live cells. The Journal of Biological Chemistry. 288: 8875-86. PMID 23393139 DOI: 10.1074/jbc.M112.421164  1
2013 Fan H, Zhao X, Sun S, Luo M, Guan JL. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. The Journal of Biological Chemistry. 288: 3322-33. PMID 23255596 DOI: 10.1074/jbc.M112.420497  1
2013 Peng X, Lin Q, Liu Y, Jin Y, Druso JE, Antonyak MA, Guan JL, Cerione RA. Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein & Cell. 4: 231-42. PMID 23150167 DOI: 10.1007/s13238-012-2098-2  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Guan JL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490  1
2012 Cai GQ, Chou CF, Hu M, Zheng A, Reichardt LF, Guan JL, Fang H, Luckhardt TR, Zhou Y, Thannickal VJ, Ding Q. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L692-702. PMID 22886502 DOI: 10.1152/ajplung.00390.2011  1
2012 Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PA. Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos. Plos One. 7: e42577. PMID 22880041 DOI: 10.1371/journal.pone.0042577  1
2012 Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. VEGF-induced vascular permeability is mediated by FAK. Developmental Cell. 22: 146-57. PMID 22264731 DOI: 10.1016/j.devcel.2011.11.002  1
2012 Wei H, Guan JL. Pro-tumorigenic function of autophagy in mammary oncogenesis. Autophagy. 8: 129-31. PMID 22082959 DOI: 10.4161/auto.8.1.18171  1
2011 Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ. Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells Journal of Cell Biology. 195: 729-738. PMID 22105351 DOI: 10.1083/jcb.201105103  1
2011 Bae H, Guan JL. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Molecular Cancer Research : McR. 9: 1232-41. PMID 21807966 DOI: 10.1158/1541-7786.MCR-11-0098  1
2011 Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature Communications. 2: 406. PMID 21792185 DOI: 10.1038/ncomms1414  1
2011 Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes & Development. 25: 1510-27. PMID 21764854 DOI: 10.1101/gad.2051011  1
2011 Wang D, Olman MA, Stewart J, Tipps R, Huang P, Sanders PW, Toline E, Prayson RA, Lee J, Weil RJ, Palmer CA, Gillespie GY, Liu WM, Pieper RO, Guan JL, et al. Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity. Plos One. 6: e19629. PMID 21602932 DOI: 10.1371/journal.pone.0019629  1
2011 Fan H, Guan JL. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. The Journal of Biological Chemistry. 286: 18573-82. PMID 21471206 DOI: 10.1074/jbc.M110.200717  1
2011 Peng X, Guan JL. Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Current Protein & Peptide Science. 12: 52-67. PMID 21190526  1
2011 Chen K, Guan J. Mapping the innovation production process from accumulative advantage to economic outcomes: A path modeling approach Technovation. 31: 336-346. DOI: 10.1016/j.technovation.2011.03.004  1
2011 Chen K, Guan J. Mapping the functionality of China's regional innovation systems: A structural approach China Economic Review. 22: 11-27. DOI: 10.1016/j.chieco.2010.08.002  1
2010 Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood. 116: 4806-14. PMID 20716775 DOI: 10.1182/blood-2010-06-288589  1
2010 Wang C, Yoo Y, Fan H, Kim E, Guan KL, Guan JL. Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration. The Journal of Biological Chemistry. 285: 29398-405. PMID 20639577 DOI: 10.1074/jbc.M110.141440  1
2010 Zhao X, Peng X, Sun S, Park AY, Guan JL. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. The Journal of Cell Biology. 189: 955-65. PMID 20530207 DOI: 10.1083/jcb.200912094  1
2010 Guan JL. Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. Iubmb Life. 62: 268-76. PMID 20101634 DOI: 10.1002/iub.303  1
2010 Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. The Journal of Clinical Investigation. 120: 485-97. PMID 20051626 DOI: 10.1172/JCI39397  1
2010 Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. The Journal of Biological Chemistry. 285: 3499-509. PMID 19940130 DOI: 10.1074/jbc.M109.072389  1
2010 Luo M, Guan JL. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Letters. 289: 127-39. PMID 19643531 DOI: 10.1016/j.canlet.2009.07.005  1
2009 Chu PY, Huang LY, Hsu CH, Liang CC, Guan JL, Hung TH, Shen TL. Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. The Journal of Biological Chemistry. 284: 20215-26. PMID 19473962 DOI: 10.1074/jbc.M109.018259  1
2009 Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Molecular Biology of the Cell. 20: 1981-91. PMID 19211835 DOI: 10.1091/mbc.E08-12-1248  1
2009 Park AY, Shen TL, Chien S, Guan JL. Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. The Journal of Biological Chemistry. 284: 9418-25. PMID 19201755 DOI: 10.1074/jbc.M809040200  1
2009 Zhao J, Guan JL. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Reviews. 28: 35-49. PMID 19169797 DOI: 10.1007/s10555-008-9165-4  1
2009 Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan JL. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Research. 69: 466-74. PMID 19147559 DOI: 10.1158/0008-5472.CAN-08-3078  1
2009 Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. The Journal of Biological Chemistry. 284: 6004-13. PMID 19106106 DOI: 10.1074/jbc.M806375200  1
2009 Guan J, Wang X. Application of integrate sensor in gas alert system of coal mine 2009 International Workshop On Intelligent Systems and Applications, Isa 2009. DOI: 10.1109/IWISA.2009.5072745  1
2008 Xie J, Allen KH, Marguet A, Berghorn KA, Bliss SP, Navratil AM, Guan JL, Roberson MS. Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone. Molecular Endocrinology (Baltimore, Md.). 22: 2322-35. PMID 18635666 DOI: 10.1210/me.2008-0061  1
2008 Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, Abouzid K, Guan JL, Tessier-Lavigne M, Lemmon V, Castellani V. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. The Embo Journal. 27: 1549-62. PMID 18464795 DOI: 10.1038/emboj.2008.86  1
2008 Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 6638-43. PMID 18448675 DOI: 10.1073/pnas.0802319105  1
2008 Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. The Journal of Cell Biology. 181: 43-50. PMID 18391070 DOI: 10.1083/jcb.200710038  1
2008 Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Molecular and Cellular Biology. 28: 2771-81. PMID 18285457 DOI: 10.1128/MCB.01210-07  1
2008 Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cellular Signalling. 20: 787-94. PMID 18036779 DOI: 10.1016/j.cellsig.2007.10.021  1
2007 Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. The Journal of Biological Chemistry. 282: 31766-76. PMID 17716968 DOI: 10.1074/jbc.M705403200  1
2007 Rhoads DS, Guan JL. Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules. Experimental Cell Research. 313: 3859-67. PMID 17640633 DOI: 10.1016/j.yexcr.2007.06.005  1
2007 Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nature Protocols. 2: 329-33. PMID 17406593 DOI: 10.1038/nprot.2007.30  1
2007 Yoo Y, Wu X, Guan JL. A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. The Journal of Biological Chemistry. 282: 7616-23. PMID 17220302 DOI: 10.1074/jbc.M607596200  1
2006 Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. The Journal of Biological Chemistry. 281: 37321-9. PMID 17043358 DOI: 10.1074/jbc.M605241200  1
2006 Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of Cell Biology. 175: 121-33. PMID 17015619 DOI: 10.1083/jcb.200604129  1
2006 Feng Q, Baird D, Peng X, Wang J, Ly T, Guan JL, Cerione RA. Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nature Cell Biology. 8: 945-56. PMID 16892055 DOI: 10.1038/ncb1453  1
2006 Wu X, Yoo Y, Okuhama NN, Tucker PW, Liu G, Guan JL. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nature Cell Biology. 8: 756-63. PMID 16767080 DOI: 10.1038/ncb1433  1
2006 Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. The Journal of Biological Chemistry. 281: 16664-71. PMID 16617055 DOI: 10.1074/jbc.M513135200  1
2006 Yoo Y, Wu X, Egile C, Li R, Guan JL. Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading. The Journal of Biological Chemistry. 281: 15352-60. PMID 16574661 DOI: 10.1074/jbc.M511825200  1
2006 Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. The Journal of Clinical Investigation. 116: 217-27. PMID 16374517 DOI: 10.1172/JCI24497  1
2005 Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Research. 65: 6676-84. PMID 16061648 DOI: 10.1158/0008-5472.CAN-04-4142  1
2005 Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Developmental Cell. 9: 185-96. PMID 16054026 DOI: 10.1016/j.devcel.2005.06.006  1
2005 Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. The Journal of Cell Biology. 170: 379-89. PMID 16043512 DOI: 10.1083/jcb.200411106  1
2005 Li S, Guan JL, Chien S. Biochemistry and biomechanics of cell motility. Annual Review of Biomedical Engineering. 7: 105-50. PMID 16004568 DOI: 10.1146/annurev.bioeng.7.060804.100340  1
2005 Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. The Journal of Cell Biology. 169: 941-52. PMID 15967814 DOI: 10.1083/jcb.200411155  1
2005 Rhoads DS, Nadkarni SM, Song L, Voeltz C, Bodenschatz E, Guan JL. Using microfluidic channel networks to generate gradients for studying cell migration. Methods in Molecular Biology (Clifton, N.J.). 294: 347-57. PMID 15576923  1
2005 Rodriguez LG, Wu X, Guan JL. Wound-healing assay. Methods in Molecular Biology (Clifton, N.J.). 294: 23-9. PMID 15576902  1
2005 Ding Q, Grammer JR, Nelson MA, Guan JL, Stewart JE, Gladson CL. p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. The Journal of Biological Chemistry. 280: 6802-15. PMID 15557280 DOI: 10.1074/jbc.M409180200  1
2005 Miao H, Strebhardt K, Pasquale EB, Shen TL, Guan JL, Wang B. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. The Journal of Biological Chemistry. 280: 923-32. PMID 15536074 DOI: 10.1074/jbc.M411383200  1
2005 Moon JJ, Matsumoto M, Patel S, Lee L, Guan JL, Li S. Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction. Journal of Cellular Physiology. 203: 166-76. PMID 15389626 DOI: 10.1002/jcp.20220  1
2005 Rodriguez LG, Guan JL. 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove. Journal of Cellular Physiology. 202: 285-94. PMID 15389601 DOI: 10.1002/jcp.20122  1
2004 Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, Nagy T, Vassalli JD, Guan JL. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovascular Research. 64: 421-30. PMID 15537495 DOI: 10.1016/j.cardiores.2004.07.012  1
2004 Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature Neuroscience. 7: 1213-21. PMID 15494734 DOI: 10.1038/nn1329  1
2004 Shen TL, Guan JL. Grb7 in intracellular signaling and its role in cell regulation. Frontiers in Bioscience : a Journal and Virtual Library. 9: 192-200. PMID 14766359  1
2004 Guan JL. Cell biology. Integrins, rafts, Rac, and Rho. Science (New York, N.Y.). 303: 773-4. PMID 14764856 DOI: 10.1126/science.1094376  1
2004 Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL. Focal adhesion kinase regulation of N-WASP subcellular localization and function. The Journal of Biological Chemistry. 279: 9565-76. PMID 14676198 DOI: 10.1074/jbc.M310739200  1
2003 Cooper LA, Shen TL, Guan JL. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Molecular and Cellular Biology. 23: 8030-41. PMID 14585964 DOI: 10.1128/MCB.23.22.8030-8041.2003  1
2003 Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular Cell. 11: 1503-15. PMID 12820964  1
2002 Abbi S, Guan JL. Focal adhesion kinase: protein interactions and cellular functions. Histology and Histopathology. 17: 1163-71. PMID 12371144  1
2002 Han DC, Shen TL, Miao H, Wang B, Guan JL. EphB1 associates with Grb7 and regulates cell migration. The Journal of Biological Chemistry. 277: 45655-61. PMID 12223469 DOI: 10.1074/jbc.M203165200  1
2002 Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL. Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Molecular Biology of the Cell. 13: 3178-91. PMID 12221124 DOI: 10.1091/mbc.E02-05-0295  1
2002 Shen TL, Han DC, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. The Journal of Biological Chemistry. 277: 29069-77. PMID 12021278 DOI: 10.1074/jbc.M203085200  1
2002 Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C. Nck-2 interacts with focal adhesion kinase and modulates cell motility. The International Journal of Biochemistry & Cell Biology. 34: 791-805. PMID 11950595  1
2002 Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 3546-51. PMID 11891289 DOI: 10.1073/pnas.052018099  1
2001 Han DC, Shen TL, Guan JL. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 20: 6315-21. PMID 11607834 DOI: 10.1038/sj.onc.1204775  1
2001 Shen TL, Guan JL. Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. Febs Letters. 499: 176-81. PMID 11418135  1
2000 Reiske HR, Zhao J, Han DC, Cooper LA, Guan JL. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. Febs Letters. 486: 275-80. PMID 11119718 DOI: 10.1016/S0014-5793(00)02295-X  1
2000 Han DC, Shen TL, Guan JL. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. The Journal of Biological Chemistry. 275: 28911-7. PMID 10893408 DOI: 10.1074/jbc.M001997200  1
2000 Ueda H, Abbi S, Zheng C, Guan JL. Suppression of Pyk2 kinase and cellular activities by FIP200. The Journal of Cell Biology. 149: 423-30. PMID 10769033 DOI: 10.1083/jcb.149.2.423  1
1999 Reiske HR, Kao SC, Cary LA, Guan JL, Lai JF, Chen HC. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. The Journal of Biological Chemistry. 274: 12361-6. PMID 10212207 DOI: 10.1074/jbc.274.18.12361  1
1998 Zhao JH, Reiske H, Guan JL. Regulation of the cell cycle by focal adhesion kinase. The Journal of Cell Biology. 143: 1997-2008. PMID 9864370  0.01
1997 Guan JL. Role of focal adhesion kinase in integrin signaling International Journal of Biochemistry and Cell Biology. 29: 1085-1096. PMID 9416004 DOI: 10.1016/S1357-2725(97)00051-4  1
1997 Guan JL. Focal adhesion kinase in integrin signaling Matrix Biology. 16: 195-200. PMID 9402009 DOI: 10.1016/S0945-053X(97)90008-1  1
1992 Hynes RO, George EL, Georges EN, Guan JL, Rayburn H, Yang JT. Toward a genetic analysis of cell-matrix adhesion. Cold Spring Harbor Symposia On Quantitative Biology. 57: 249-58. PMID 1339663  1
1991 Guan JL, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regulation. 2: 951-64. PMID 1725602  1
1990 Guan JL, Trevithick JE, Hynes RO. Retroviral expression of alternatively spliced forms of rat fibronectin. The Journal of Cell Biology. 110: 833-47. PMID 2307710  1
1990 Guan JL, Hynes RO. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 60: 53-61. PMID 2295088  1
1990 Marcantonio EE, Guan JL, Trevithick JE, Hynes RO. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation. 1: 597-604. PMID 2078570  1
1989 Solowska J, Guan JL, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO. Expression of normal and mutant avian integrin subunits in rodent cells. The Journal of Cell Biology. 109: 853-61. PMID 2788168  1
1988 Guan JL, Ruusala A, Cao H, Rose JK. Effects of altered cytoplasmic domains on transport of the vesicular stomatitis virus glycoprotein are transferable to other proteins. Molecular and Cellular Biology. 8: 2869-74. PMID 2841589  1
1988 Fukuda M, Guan JL, Rose JK. A membrane-anchored form but not the secretory form of human chorionic gonadotropin-alpha chain acquires polylactosaminoglycan. The Journal of Biological Chemistry. 263: 5314-8. PMID 2451668  1
1988 Guan JL, Cao H, Rose JK. Cell-surface expression of a membrane-anchored form of the human chorionic gonadotropin alpha subunit. The Journal of Biological Chemistry. 263: 5306-13. PMID 2451667  1
1985 Guan JL, Machamer CE, Rose JK. Glycosylation allows cell-surface transport of an anchored secretory protein. Cell. 42: 489-96. PMID 3928168 DOI: 10.1016/0092-8674(85)90106-0  1
1984 Guan JL, Rose JK. Conversion of a secretory protein into a transmembrane protein results in its transport to the Golgi complex but not to the cell surface. Cell. 37: 779-87. PMID 6589049  1
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