Michael D. Schaller - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Cell Biology, Biochemistry

84 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Frisch SM, Schaller MD. The wind god promotes lung cancer. Cancer Cell. 25: 551-2. PMID 24823631 DOI: 10.1016/j.ccr.2014.04.022  1
2014 Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT. SRChing for the substrates of Src. Oncogene. 33: 4537-47. PMID 24121272 DOI: 10.1038/onc.2013.416  1
2013 Frisch SM, Schaller M, Cieply B. Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. Journal of Cell Science. 126: 21-9. PMID 23516327 DOI: 10.1242/jcs.120907  1
2013 Hartman ZR, Schaller MD, Agazie YM. The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration. Molecular Cancer Research : McR. 11: 651-64. PMID 23512980 DOI: 10.1158/1541-7786.MCR-12-0578  1
2012 Fu W, Hall JE, Schaller MD. Focal adhesion kinase-regulated signaling events in human cancer. Biomolecular Concepts. 3: 225-40. PMID 25436535 DOI: 10.1515/bmc-2011-0049  1
2012 Cable J, Prutzman K, Gunawardena HP, Schaller MD, Chen X, Campbell SL. In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by Src kinase. Biochemistry. 51: 2213-23. PMID 22372511 DOI: 10.1021/bi300123a  1
2011 Hall JE, Fu W, Schaller MD. Focal adhesion kinase: exploring Fak structure to gain insight into function. International Review of Cell and Molecular Biology. 288: 185-225. PMID 21482413 DOI: 10.1016/B978-0-12-386041-5.00005-4  1
2010 Espejo R, Rengifo-Cam W, Schaller MD, Evers BM, Sastry SK. PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells. American Journal of Physiology. Cell Physiology. 299: C454-63. PMID 20519451 DOI: 10.1152/ajpcell.00148.2010  1
2010 Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, Carroll AR, Spannuth WA, Deavers MT, Allen JK, Han LY, Kamat AA, Shahzad MM, McIntyre BW, Diaz-Montero CM, ... ... Schaller MD, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. The Journal of Clinical Investigation. 120: 1515-23. PMID 20389021 DOI: 10.1172/JCI40802  1
2010 Schaller MD, Frisch SM. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biology & Therapy. 9: 791-3. PMID 20364110  1
2010 Schaller MD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. Journal of Cell Science. 123: 1007-13. PMID 20332118 DOI: 10.1242/jcs.045112  1
2010 Schaller MD, Frisch SM. Commentary on Tanjoni, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments Cancer Biology and Therapy. 9: 789-791.  1
2009 Chellaiah MA, Schaller MD. Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro. Journal of Cellular Physiology. 220: 382-93. PMID 19350555 DOI: 10.1002/jcp.21777  1
2009 Palmer SM, Playford MP, Craig SW, Schaller MD, Campbell SL. Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini. The Journal of Biological Chemistry. 284: 7223-31. PMID 19110481 DOI: 10.1074/jbc.M807842200  1
2008 Palmer SM, Schaller MD, Campbell SL. Vinculin tail conformation and self-association is independent of pH and H906 protonation. Biochemistry. 47: 12467-75. PMID 18980387 DOI: 10.1021/bi801764a  1
2008 Playford MP, Vadali K, Cai X, Burridge K, Schaller MD. Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho. Experimental Cell Research. 314: 3187-97. PMID 18773890 DOI: 10.1016/j.yexcr.2008.08.010  1
2008 Schaller MD. Calcium-dependent Pyk2 activation: a role for calmodulin? The Biochemical Journal. 410: e3-4. PMID 18290763 DOI: 10.1042/BJ20080133  1
2008 Scheswohl DM, Harrell JR, Rajfur Z, Gao G, Campbell SL, Schaller MD. Multiple paxillin binding sites regulate FAK function. Journal of Molecular Signaling. 3: 1. PMID 18171471 DOI: 10.1186/1750-2187-3-1  1
2008 Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Molecular and Cellular Biology. 28: 201-14. PMID 17967873 DOI: 10.1128/MCB.01324-07  1
2007 Zayed MA, Yuan W, Leisner TM, Chalothorn D, McFadden AW, Schaller MD, Hartnett ME, Faber JE, Parise LV. CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesis. Circulation Research. 101: 1185-93. PMID 17975111 DOI: 10.1161/CIRCRESAHA.107.157586  1
2007 Vadali K, Cai X, Schaller MD. Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions. Iubmb Life. 59: 709-16. PMID 17968709 DOI: 10.1080/15216540701694245  1
2007 Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Structural basis for the autoinhibition of focal adhesion kinase. Cell. 129: 1177-87. PMID 17574028 DOI: 10.1016/j.cell.2007.05.041  1
2006 Playford MP, Lyons PD, Sastry SK, Schaller MD. Identification of a filamin docking site on PTP-PEST. The Journal of Biological Chemistry. 281: 34104-12. PMID 16973606 DOI: 10.1074/jbc.M606277200  1
2006 Cai X, Li M, Vrana J, Schaller MD. Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Molecular and Cellular Biology. 26: 2857-68. PMID 16537926 DOI: 10.1128/MCB.26.7.2857-2868.2006  1
2006 Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ. Crystal structure of the FERM domain of focal adhesion kinase. The Journal of Biological Chemistry. 281: 252-9. PMID 16221668 DOI: 10.1074/jbc.M509188200  1
2005 Halder J, Landen CN, Lutgendorf SK, Li Y, Jennings NB, Fan D, Nelkin GM, Schmandt R, Schaller MD, Sood AK. Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 8829-36. PMID 16361572 DOI: 10.1158/1078-0432.CCR-05-1728  1
2005 Cai L, Holoweckyj N, Schaller MD, Bear JE. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. The Journal of Biological Chemistry. 280: 31913-23. PMID 16027158 DOI: 10.1074/jbc.M504146200  1
2005 Horner TJ, Osawa S, Schaller MD, Weiss ER. Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. The Journal of Biological Chemistry. 280: 28241-50. PMID 15946941 DOI: 10.1074/jbc.M505117200  1
2005 Humphrey D, Rajfur Z, Vazquez ME, Scheswohl D, Schaller MD, Jacobson K, Imperiali B. In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells. The Journal of Biological Chemistry. 280: 22091-101. PMID 15817454 DOI: 10.1074/jbc.M502726200  1
2005 Iyer VV, Ballestrem C, Kirchner J, Geiger B, Schaller MD. Measurement of protein tyrosine phosphorylation in cell adhesion. Methods in Molecular Biology (Clifton, N.J.). 294: 289-302. PMID 15576919  1
2004 Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene. 23: 7928-46. PMID 15489911 DOI: 10.1038/sj.onc.1208080  1
2004 Sood AK, Coffin JE, Schneider GB, Fletcher MS, DeYoung BR, Gruman LM, Gershenson DM, Schaller MD, Hendrix MJ. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. The American Journal of Pathology. 165: 1087-95. PMID 15466376 DOI: 10.1016/S0002-9440(10)63370-6  1
2004 Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. Journal of Cell Science. 117: 4619-28. PMID 15371522 DOI: 10.1242/jcs.01481  1
2004 Schaller MD. FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration? The Journal of Cell Biology. 166: 157-9. PMID 15263014 DOI: 10.1083/jcb.200406151  1
2004 Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD. FERM domain interaction promotes FAK signaling. Molecular and Cellular Biology. 24: 5353-68. PMID 15169899 DOI: 10.1128/MCB.24.12.5353-5368.2004  1
2004 Prutzman KC, Gao G, King ML, Iyer VV, Mueller GA, Schaller MD, Campbell SL. The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation. Structure (London, England : 1993). 12: 881-91. PMID 15130480 DOI: 10.1016/j.str.2004.02.028  1
2004 Huang C, Borchers CH, Schaller MD, Jacobson K. Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells. The Journal of Cell Biology. 164: 593-602. PMID 14970194 DOI: 10.1083/jcb.200307081  1
2004 Gao G, Prutzman KC, King ML, Scheswohl DM, DeRose EF, London RE, Schaller MD, Campbell SL. NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model. The Journal of Biological Chemistry. 279: 8441-51. PMID 14662767 DOI: 10.1074/jbc.M309808200  0.44
2004 Huang C, Jacobson K, Schaller MD. A role for JNK-paxillin signaling in cell migration. Cell Cycle (Georgetown, Tex.). 3: 4-6. PMID 14657652  1
2003 Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Schaller MD, Anderson RA. Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. The Journal of Cell Biology. 163: 1339-49. PMID 14691141 DOI: 10.1083/jcb.200310067  1
2003 Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC. A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Current Biology : Cb. 13: 1442-50. PMID 12932330 DOI: 10.1016/S0960-9822(03)00544-X  1
2003 Gabarra-Niecko V, Schaller MD, Dunty JM. FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Reviews. 22: 359-74. PMID 12884911 DOI: 10.1023/A:1023725029589  1
2003 Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature. 424: 219-23. PMID 12853963 DOI: 10.1038/nature01745  1
2002 Schneider GB, Kurago Z, Zaharias R, Gruman LM, Schaller MD, Hendrix MJ. Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. Cancer. 95: 2508-15. PMID 12467064 DOI: 10.1002/cncr.10992  1
2002 Sastry SK, Lyons PD, Schaller MD, Burridge K. PTP-PEST controls motility through regulation of Rac1. Journal of Cell Science. 115: 4305-16. PMID 12376562 DOI: 10.1242/jcs.00105  1
2002 Dunty JM, Schaller MD. The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology. The Journal of Biological Chemistry. 277: 45644-54. PMID 12223467 DOI: 10.1074/jbc.M201779200  1
2002 Gabarra-Niecko V, Keely PJ, Schaller MD. Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'. The Biochemical Journal. 365: 591-603. PMID 11988069 DOI: 10.1042/BJ20020065  1
2001 Horsch K, Schaller MD, Hynes NE. The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cells Molecular Endocrinology. 15: 2182-2196. PMID 11731619 DOI: 10.1210/me.15.12.2182  1
2001 Schaller MD, Schaefer EM. Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin Biochemical Journal. 360: 57-66. PMID 11695992 DOI: 10.1042/0264-6021:3600057  1
2001 Schaller MD. Paxillin: A focal adhesion-associated adaptor protein Oncogene. 20: 6459-6472. PMID 11607845 DOI: 10.1038/sj.onc.1204786  1
2001 Schaller MD. Biochemical signals and biological responses elicited by the focal adhesion kinase Biochimica Et Biophysica Acta - Molecular Cell Research. 1540: 1-21. PMID 11476890 DOI: 10.1016/S0167-4889(01)00123-9  1
2001 Lyons PD, Dunty JM, Schaefer EM, Schaller MD. Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation. The Journal of Biological Chemistry. 276: 24422-31. PMID 11337490 DOI: 10.1074/jbc.M011080200  1
2000 Cooley MA, Broome JM, Ohngemach C, Romer LH, Schaller MD. Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase Molecular Biology of the Cell. 11: 3247-3263. PMID 10982414  1
2000 Schaller MD. UNC112: A new regulator of cell-extracellular matrix adhesions? Journal of Cell Biology. 150. PMID 10893277 DOI: 10.1083/jcb.150.1.f9  1
2000 Shen Y, Lyonst P, Cooley M, Davidson D, Veillette A, Salgiall R, Griffin JD, Schaller MD. The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo Journal of Biological Chemistry. 275: 1405-1413. PMID 10625692 DOI: 10.1074/jbc.275.2.1405  1
1999 Thomas JW, Cooley MA, Broome JM, Salgia R, Griffin JD, Lombardo CR, Schaller MD. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin Journal of Biological Chemistry. 274: 36684-36692. PMID 10593973 DOI: 10.1074/jbc.274.51.36684  1
1999 Schaller MD, Hildebrand JD, Parsons JT. Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases Molecular Biology of the Cell. 10: 3489-3505. PMID 10512882 DOI: 10.1091/mbc.10.10.3489  1
1999 Shen Y, Schaller MD. Focal adhesion targeting: The critical determinant of FAK regulation and substrate phosphorylation Molecular Biology of the Cell. 10: 2507-2518. PMID 10436008  1
1999 Schmid RS, Graff RD, Schaller MD, Chen S, Schachner M, Hemperly JJ, Maness PF. NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells. Journal of Neurobiology. 38: 542-58. PMID 10084688 DOI: 10.1002/(SICI)1097-4695(199903)38:4<542::AID-NEU9>3.0.CO;2-1  1
1998 Shen Y, Schneider G, Cloutier JF, Veillette A, Schaller MD. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. The Journal of Biological Chemistry. 273: 6474-81. PMID 9497381 DOI: 10.1074/jbc.273.11.6474  1
1998 Thomas JW, Ellis B, Boerner RJ, Knight WB, White GC, Schaller MD. SH2- and SH3-mediated interactions between focal adhesion kinase and Src. The Journal of Biological Chemistry. 273: 577-83. PMID 9417118 DOI: 10.1074/jbc.273.1.577  1
1997 Schaller MD, Sasaki T. Differential signaling by the focal adhesion kinase and cell adhesion kinase β Journal of Biological Chemistry. 272: 25319-25325. PMID 9312150 DOI: 10.1074/jbc.272.40.25319  1
1997 Richardson A, Shannon JD, Adams RB, Schaller MD, Parsons J. Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A. The Biochemical Journal. 324: 141-9. PMID 9164850  1
1997 Lin TH, Aplin AE, Shen Y, Chen Q, Schaller M, Romer L, Aukhil I, Juliano RL. Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. The Journal of Cell Biology. 136: 1385-95. PMID 9087451 DOI: 10.1083/jcb.136.6.1385  0.32
1997 Schaller MD. Signaling through the focal adhesion kinase Journal of General Physiology. 241-255.  1
1996 Schaller MD. The focal adhesion kinase Journal of Endocrinology. 150: 1-7. PMID 8708550 DOI: 10.1677/joe.0.1500001  1
1995 Schwartz MA, Schaller MD, Ginsberg MH. Integrins: Emerging paradigms of signal transduction Annual Review of Cell and Developmental Biology. 11: 549-599. PMID 8689569  1
1995 Schaller MD, Otey CA, Hildebrand JD, Parsons JT. Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains Journal of Cell Biology. 130: 1181-1187. PMID 7657702 DOI: 10.1083/jcb.130.5.1181  1
1995 Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL. Interaction of focal adhesion kinase with cytoskeletal protein talin Journal of Biological Chemistry. 270: 16995-16999. PMID 7622520 DOI: 10.1074/jbc.270.28.16995  1
1995 Hildebrand JD, Schaller MD, Parsons JT. Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase Molecular Biology of the Cell. 6: 637-647. PMID 7579684 DOI: 10.1091/mbc.6.6.637  1
1995 Schaller MD, Parsons JT. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk Molecular and Cellular Biology. 15: 2635-2645. PMID 7537852  1
1994 Parsons JT, Schaller MD, Hildebrand J, Leu TH, Richardson A, Otey C. Focal adhesion kinase: structure and signalling. Journal of Cell Science. Supplement. 18: 109-13. PMID 7883785 DOI: 10.1242/jcs.1994.Supplement_18.16  1
1994 Schaller MD, Thomas Parsons J. Focal adhesion kinase and associated proteins Current Opinion in Cell Biology. 6: 705-710. PMID 7833050 DOI: 10.1016/0955-0674(94)90097-3  1
1994 Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T. SH2 domain specificity and activity modified by a single residue. Nature. 369: 502-5. PMID 7515480 DOI: 10.1038/369502a0  1
1994 Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Molecular and Cellular Biology. 14: 1680-1688. PMID 7509446 DOI: 10.1128/MCB.14.3.1680  1
1994 Cobb BS, Schaller MD, Leu TH, Parsons JT. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Molecular and Cellular Biology. 14: 147-55. PMID 7505391  1
1993 Schaller MD, Bouton AH, Flynn DC, Parsons JT. Identification and characterization of novel substrates for protein tyrosine kinases Progress in Nucleic Acid Research and Molecular Biology. 44: 205-227. PMID 8434124 DOI: 10.1016/S0079-6603(08)60221-4  1
1993 Schaller MD, Borgman CA, Parsons JT. Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125FAK Molecular and Cellular Biology. 13: 785-791. PMID 8423801  1
1993 Turner CE, Schaller MD, Parsons JT. Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: Relation to paxillin Journal of Cell Science. 105: 637-645. PMID 8408291  1
1993 Hildebrand JD, Schaller MD, Parsons JT. Identification of sequences required for the efficient localization of the Focal Adhesion Kinase, pp125FAK, to cellular focal adhesions Journal of Cell Biology. 123: 993-1005. PMID 8227154 DOI: 10.1083/jcb.123.4.993  1
1993 Schaller MD, Parsons JT. Focal adhesion kinase: an integrin-linked protein tyrosine kinase Trends in Cell Biology. 3: 258-262. DOI: 10.1016/0962-8924(93)90053-4  1
1992 Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proceedings of the National Academy of Sciences of the United States of America. 89: 5192-6. PMID 1594631  1
1992 Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets Journal of Cell Biology. 119: 905-912. PMID 1385445  1
1992 Flynn DC, Schaller MD, Parsons JT. Tyrosine phosphorylation of a 120 000 dalton membrane-associated protein by the neural form of pp60c-src pp60c-src+ Oncogene. 7: 579-583. PMID 1372401  1
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