Bruce Demple - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Molecular Biology, Biochemistry

172 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Quiñones JL, Demple B. When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions. Dna Repair. PMID 27264558 DOI: 10.1016/j.dnarep.2016.05.014  1
2016 Vacchi-Suzzi C, Porucznik CA, Cox KJ, Zhao Y, Ahn H, Harrington JM, Levine KE, Demple B, Marsit CJ, Gonzalez A, Luft B, Meliker JR. Temporal variability of urinary cadmium in spot urine samples and first morning voids. Journal of Exposure Science & Environmental Epidemiology. PMID 27168395 DOI: 10.1038/jes.2016.28  1
2015 Suresh Kumar MA, Peluso M, Chaudhary P, Dhawan J, Beheshti A, Manickam K, Thapar U, Pena L, Natarajan M, Hlatky L, Demple B, Naidu M. Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1. Plos One. 10: e0133016. PMID 26208353 DOI: 10.1371/journal.pone.0133016  1
2015 Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B. Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124145 DOI: 10.1073/pnas.1501101112  1
2015 Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G. Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology. Oncogene. 34: 3482. PMID 26109248 DOI: 10.1038/onc.2015.191  1
2015 Tell G, Demple B. Base excision DNA repair and cancer. Oncotarget. 6: 584-5. PMID 25655644 DOI: 10.18632/oncotarget.2705  1
2014 Vascotto C, Lirussi L, Poletto M, Tiribelli M, Damiani D, Fabbro D, Damante G, Demple B, Colombo E, Tell G. Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology. Oncogene. 33: 2876-87. PMID 23831574 DOI: 10.1038/onc.2013.251  1
2013 Madlener S, Ströbel T, Vose S, Saydam O, Price BD, Demple B, Saydam N. Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance. Proceedings of the National Academy of Sciences of the United States of America. 110: 17844-9. PMID 24127576 DOI: 10.1073/pnas.1304784110  1
2012 Liu C, Kim E, Demple B, Seeman NC. A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein. Biochemistry. 51: 937-43. PMID 22257222 DOI: 10.1021/bi201196s  1
2011 Fung H, Demple B. Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. The Journal of Biological Chemistry. 286: 4968-77. PMID 21081487 DOI: 10.1074/jbc.M110.146498  1
2010 Liu P, Demple B. DNA repair in mammalian mitochondria: Much more than we thought? Environmental and Molecular Mutagenesis. 51: 417-26. PMID 20544882 DOI: 10.1002/em.20576  1
2010 Auerbach PA, Demple B. Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae. Mutagenesis. 25: 63-9. PMID 19901007 DOI: 10.1093/mutage/gep045  1
2010 Demple B. Oxidative stress and free radical signal transduction Handbook of Cell Signaling, 2/E. 3: 2137-2143. DOI: 10.1016/B978-0-12-374145-5.00259-X  1
2009 Son MY, Jun HI, Lee KG, Demple B, Sung JS. Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones. Journal of Toxicology and Environmental Health. Part A. 72: 1311-7. PMID 20077202 DOI: 10.1080/15287390903212402  1
2009 Kuwano Y, Rabinovic A, Srikantan S, Gorospe M, Demple B. Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation. Molecular and Cellular Biology. 29: 2622-35. PMID 19289500 DOI: 10.1128/MCB.01495-08  1
2008 Zheng L, Zhou M, Guo Z, Lu H, Qian L, Dai H, Qiu J, Yakubovskaya E, Bogenhagen DF, Demple B, Shen B. Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Molecular Cell. 32: 325-36. PMID 18995831 DOI: 10.1016/j.molcel.2008.09.024  1
2008 Demple B. Community organizers and (bio)filmmaking. Nature Chemical Biology. 4: 653-4. PMID 18936747 DOI: 10.1038/nchembio1108-653  1
2008 Liu P, Qian L, Sung JS, de Souza-Pinto NC, Zheng L, Bogenhagen DF, Bohr VA, Wilson DM, Shen B, Demple B. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Molecular and Cellular Biology. 28: 4975-87. PMID 18541666 DOI: 10.1128/MCB.00457-08  1
2008 Gellon L, Carson DR, Carson JP, Demple B. Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. Dna Repair. 7: 187-98. PMID 17983848 DOI: 10.1016/j.dnarep.2007.09.009  1
2008 Demple B. Iron in redox-regulated and nitric oxide-induced gene expression Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. 177-185. DOI: 10.1002/9783527613700.ch11  1
2008 Gorodetsky AA, Dietrich LEP, Lee PE, Demple B, Newman DK, Barton JK, Watanabe S, Kita A, Kobayashi K, Miki K, Taylor JL, Moga TG, Karagiaridi O, Wilcox DE, Pletneva EV. Effects of DNA binding on the structural and redox properties of the [2fe-2s] transcription factor soxr Chemtracts. 21: 336-345.  1
2007 Leautaud V, Demple B. Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress. Bmc Molecular Biology. 8: 116. PMID 18096048 DOI: 10.1186/1471-2199-8-116  1
2007 Narciso L, Fortini P, Pajalunga D, Franchitto A, Liu P, Degan P, Frechet M, Demple B, Crescenzi M, Dogliotti E. Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury. Proceedings of the National Academy of Sciences of the United States of America. 104: 17010-5. PMID 17940040 DOI: 10.1073/pnas.0701743104  1
2007 Fung H, Liu P, Demple B. ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Molecular and Cellular Biology. 27: 8834-47. PMID 17938202 DOI: 10.1128/MCB.00974-07  1
2007 Demple B, Ding H, Ren B, Reiter TA. Harnessing toxic reactions to signal stress: Reactions of nitric oxide with iron-sulfur centers and the informative case of SoxR protein Radicals For Life: the Various Forms of Nitric Oxide. 147-160. DOI: 10.1016/B978-044452236-8/50007-1  1
2006 Reiter TA, Pang B, Dedon P, Demple B. Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. The Journal of Biological Chemistry. 281: 36603-12. PMID 17020887 DOI: 10.1074/jbc.M602634200  1
2006 Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Molecular Cell. 23: 133-42. PMID 16818237 DOI: 10.1016/j.molcel.2006.06.005  1
2006 Sung JS, Demple B. Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links. Methods in Enzymology. 408: 48-64. PMID 16793362 DOI: 10.1016/S0076-6879(06)08004-9  1
2006 Sung JS, Demple B. Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA. The Febs Journal. 273: 1620-9. PMID 16623699 DOI: 10.1111/j.1742-4658.2006.05192.x  1
2006 Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Demple B, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/j.cell.2005.11.044  1
2006 Park W, Peña-Llopis S, Lee Y, Demple B. Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli. Biochemical and Biophysical Research Communications. 341: 51-6. PMID 16412384 DOI: 10.1016/j.bbrc.2005.12.142  1
2006 Lee Y, Peña-Llopis S, Kang YS, Shin HD, Demple B, Madsen EL, Jeon CO, Park W. Expression analysis of the fpr (ferredoxin-NADP+ reductase) gene in Pseudomonas putida KT2440. Biochemical and Biophysical Research Communications. 339: 1246-54. PMID 16360643 DOI: 10.1016/j.bbrc.2005.11.135  1
2005 Auerbach P, Bennett RA, Bailey EA, Krokan HE, Demple B. Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proceedings of the National Academy of Sciences of the United States of America. 102: 17711-6. PMID 16314579 DOI: 10.1073/pnas.0504643102  1
2005 Demple B, Sung JS. Molecular and biological roles of Ape1 protein in mammalian base excision repair. Dna Repair. 4: 1442-9. PMID 16199212 DOI: 10.1016/j.dnarep.2005.09.004  1
2005 Reiter TA, Demple B. Carbon monoxide mediates protection against nitric oxide toxicity in HeLa cells. Free Radical Biology & Medicine. 39: 1075-88. PMID 16198234 DOI: 10.1016/j.freeradbiomed.2005.05.023  1
2005 Sung JS, DeMott MS, Demple B. Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta. The Journal of Biological Chemistry. 280: 39095-103. PMID 16188889 DOI: 10.1074/jbc.M506480200  1
2005 McLaughlin LM, Demple B. Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. Cancer Research. 65: 6097-104. PMID 16024610 DOI: 10.1158/0008-5472.CAN-04-4254  1
2005 Koutsolioutsou A, Peña-Llopis S, Demple B. Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates. Antimicrobial Agents and Chemotherapy. 49: 2746-52. PMID 15980345 DOI: 10.1128/AAC.49.7.2746-2752.2005  1
2005 Fung H, Demple B. A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. Molecular Cell. 17: 463-70. PMID 15694346 DOI: 10.1016/j.molcel.2004.12.029  1
2004 Bishop A, Yet SF, Lee ME, Perrella MA, Demple B. A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. Biochemical and Biophysical Research Communications. 325: 3-9. PMID 15522193 DOI: 10.1016/j.bbrc.2004.10.010  1
2004 Chander M, Demple B. Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression. The Journal of Biological Chemistry. 279: 41603-10. PMID 15292172 DOI: 10.1074/jbc.M405512200  1
2004 Demple B. Protection from the dark side of NO: signaling and cellular defenses against nitric oxide toxicity. Iubmb Life. 56: 59-64. PMID 15085929 DOI: 10.1080/15216540310001659010  1
2004 Wong D, Demple B. Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1. The Journal of Biological Chemistry. 279: 25268-75. PMID 15078879 DOI: 10.1074/jbc.M400804200  1
2004 Demple B. Grasping the message: regulated mRNA stability in free radical stress responses. Rodríguez-Gabriel MA, Burns G, McDonald WH et al. RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress. EMBO J 2003; 22: 6256-6266. Redox Report : Communications in Free Radical Research. 9: 3-5. PMID 15035822 DOI: 10.1179/135100004225003932  1
2003 Pomposiello PJ, Koutsolioutsou A, Carrasco D, Demple B. SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. Journal of Bacteriology. 185: 6624-32. PMID 14594836 DOI: 10.1128/JB.185.22.6624-6632.2003  1
2003 Wong D, DeMott MS, Demple B. Modulation of the 3'-->5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product. The Journal of Biological Chemistry. 278: 36242-9. PMID 12857737 DOI: 10.1074/jbc.M306065200  1
2003 Mitsumoto M, Mitsumoto A, Demple B. Nitric oxide-mediated upregulation of the TGF-beta-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-beta. Free Radical Biology & Medicine. 34: 1607-13. PMID 12788480 DOI: 10.1016/S0891-5849(03)00211-9  1
2003 Chander M, Raducha-Grace L, Demple B. Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization. Journal of Bacteriology. 185: 2441-50. PMID 12670967 DOI: 10.1128/JB.185.8.2441-2450.2003  1
2003 Xu YJ, DeMott MS, Hwang JT, Greenberg MM, Demple B. Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. Dna Repair. 2: 175-85. PMID 12531388 DOI: 10.1016/S1568-7864(02)00194-5  1
2002 Demple B, DeMott MS. Dynamics and diversions in base excision DNA repair of oxidized abasic lesions. Oncogene. 21: 8926-34. PMID 12483509 DOI: 10.1038/sj.onc.1206178  1
2002 Demple B. Signal transduction by nitric oxide in cellular stress responses. Molecular and Cellular Biochemistry. 234: 11-8. PMID 12162422 DOI: 10.1023/A:1015933216079  1
2002 Pomposiello PJ, Demple B. Global adjustment of microbial physiology during free radical stress. Advances in Microbial Physiology. 46: 319-41. PMID 12073656 DOI: 10.1016/S0065-2911(02)46007-9  1
2002 Demple B, Ding H, Jorgensen M. Escherichia coli SoxR protein: sensor/transducer of oxidative stress and nitric oxide. Methods in Enzymology. 348: 355-64. PMID 11885291  0.32
2002 DeMott MS, Beyret E, Wong D, Bales BC, Hwang JT, Greenberg MM, Demple B. Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. The Journal of Biological Chemistry. 277: 7637-40. PMID 11805079 DOI: 10.1074/jbc.C100577200  1
2001 Agnez-Lima LF, Di Mascio P, Demple B, Menck CFM. Singlet molecular oxygen triggers the soxRS regulon of Escherichia coli Biological Chemistry. 382: 1071-1075. PMID 11530938 DOI: 10.1515/BC.2001.134  1
2001 Pomposiello PJ, Bennik MHJ, Demple B. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate Journal of Bacteriology. 183: 3890-3902. PMID 11395452 DOI: 10.1128/JB.183.13.3890-3902.2001  1
2001 Eide L, Luna L, Gustad EC, Henderson PT, Essigmann JM, Demple B, Seeberg E. Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA. Biochemistry. 40: 6653-9. PMID 11380260 DOI: 10.1021/bi0028901  1
2001 Pomposiello PJ, Demple B. Redox-operated genetic switches: The SoxR and OxyR transcription factors Trends in Biotechnology. 19: 109-114. PMID 11179804 DOI: 10.1016/S0167-7799(00)01542-0  1
2001 Yang H, Clendenin WM, Wong D, Demple B, Slupska MM, Chiang JH, Miller JH. Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch. Nucleic Acids Research. 29: 743-52. PMID 11160897  1
2001 Koutsolioutsou A, Martins EA, White DG, Levy SB, Demple B. A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium). Antimicrobial Agents and Chemotherapy. 45: 38-43. PMID 11120941 DOI: 10.1128/AAC.45.1.38-43.2001  1
2001 Fung H, Bennett RAO, Demple B. Key Role of a Downstream Specificity Protein 1 Site in Cell Cycle-regulated Transcription of the AP Endonuclease Gene APE1/APEX in NIH3T3 Cells Journal of Biological Chemistry. 276: 42011-42017. DOI: 10.1074/jbc.M106423200  1
2000 Wu MT, Demple B, Bennett RAO, Christiani DC, Fan R, Hu H. Individual variability in the zinc inducibility of metallothionein-II(A) mRNA in human lymphocytes Journal of Toxicology and Environmental Health - Part A. 61: 553-567. PMID 11127411  1
2000 Bouton C, Demple B. Nitric oxide-inducible expression of heme oxygenase-1 in human cells. Translation-independent stabilization of the mRNA and evidence for direct action of nitric oxide Journal of Biological Chemistry. 275: 32688-32693. PMID 11032845  1
2000 González-Flecha B, Demple B. Genetic responses to free radicals. Homeostasis and gene control Annals of the New York Academy of Sciences. 899: 69-87. PMID 10863530  1
2000 Bennik MH, Pomposiello PJ, Thorne DF, Demple B. Defining a rob regulon in Escherichia coli by using transposon mutagenesis. Journal of Bacteriology. 182: 3794-801. PMID 10850996 DOI: 10.1128/JB.182.13.3794-3801.2000  1
2000 Ding H, Demple B. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers SoxR transcription activator Proceedings of the National Academy of Sciences of the United States of America. 97: 5146-5150. PMID 10805777 DOI: 10.1073/pnas.97.10.5146  1
2000 Kwon HJ, Bennik MHJ, Demple B, Ellenberger T. Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA Nature Structural Biology. 7: 424-430. PMID 10802742 DOI: 10.1038/75213  1
2000 Pomposiello PJ, Demple B. Identification of SoxS-regulated genes in Salmonella enterica serovar Typhimurium Journal of Bacteriology. 182: 23-29. PMID 10613858  1
1999 Demple B. Genetic responses against nitric oxide toxicity Brazilian Journal of Medical and Biological Research. 32: 1417-1427. PMID 10559844  1
1999 González-Flecha B, Demple B. Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli Journal of Bacteriology. 181: 3833-3836. PMID 10368161  1
1999 Bishop A, Marquis JC, Cashman NR, Demple B. Adaptive resistance to nitric oxide in motor neurons Free Radical Biology and Medicine. 26: 978-986. PMID 10232842 DOI: 10.1016/S0891-5849(98)00284-6  1
1999 Demple B, Hidalgo E, Ding H. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response Biochemical Society Symposium. 64: 119-128. PMID 10207625  1
1999 Demple B. Radical ideas: Genetic responses to oxidative stress Clinical and Experimental Pharmacology and Physiology. 26: 64-68. PMID 10027072 DOI: 10.1046/j.1440-1681.1999.02993.x  1
1999 Chaudhry MA, Dedon PC, Wilson DM, Demple B, Weinfeld M. Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and γ-radiation Biochemical Pharmacology. 57: 531-538. PMID 9952316 DOI: 10.1016/S0006-2952(98)00327-X  1
1998 Ding H, Demple B. Thiol-mediated disassembly and reassembly of [2Fe-2S] clusters in the redox-regulated transcription factor SoxR Biochemistry. 37: 17280-17286. PMID 9860842 DOI: 10.1021/bi980532g  1
1998 Masuda Y, Bennett RAO, Demple B. Rapid dissociation of human apurinic endonuclease (Ape1) from incised DNA induced by magnesium Journal of Biological Chemistry. 273: 30360-30365. PMID 9804799 DOI: 10.1074/jbc.273.46.30360  1
1998 Masuda Y, Bennett RAO, Demple B. Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product Journal of Biological Chemistry. 273: 30352-30359. PMID 9804798 DOI: 10.1074/jbc.273.46.30352  1
1998 Xu YJ, Kim EY, Demple B. Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase Journal of Biological Chemistry. 273: 28837-28844. PMID 9786884 DOI: 10.1074/jbc.273.44.28837  1
1998 Marquis JC, Demple B. Complex genetic response of human cells to sublethal levels of pure nitric oxide Cancer Research. 58: 3435-3440. PMID 9699677  1
1998 Hidalgo E, Leautaud V, Demple B. The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator. The Embo Journal. 17: 2629-36. PMID 9564045 DOI: 10.1093/emboj/17.9.2629  1
1998 Demple B. A bridge to control Science. 279: 1655-1656. PMID 9518377 DOI: 10.1126/science.279.5357.1655  1
1997 Harrison L, Ascione AG, Takiguchi Y, Wilson DM, Chen DJ, Demple B. Comparison of the promoters of the mouse (APEX) and human (APE) apurinic endonuclease genes Mutation Research - Dna Repair. 385: 159-172. PMID 9506886 DOI: 10.1016/S0921-8777(97)00053-0  1
1997 Borrello S, Demple B. NFκB-independent transcriptional induction of the human manganous superoxide dismutase gene Archives of Biochemistry and Biophysics. 348: 289-294. PMID 9434740 DOI: 10.1006/abbi.1997.0355  1
1997 González-Flecha B, Demple B. Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth Journal of Bacteriology. 179: 6181-6186. PMID 9324269  1
1997 White DG, Goldman JD, Demple B, Levy SB. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. Journal of Bacteriology. 179: 6122-6. PMID 9324261  1
1997 Demple B, Harrison L, Wilson DM, Bennett RAO, Takagi T, Ascione AG. Regulation of eukaryotic abasic endonucleases and their role in genetic stability Environmental Health Perspectives. 105: 931-934. PMID 9255583  1
1997 Ding H, Demple B. In vivo kinetics of a redox-regulated transcriptional switch Proceedings of the National Academy of Sciences of the United States of America. 94: 8445-8449. PMID 9237996 DOI: 10.1073/pnas.94.16.8445  1
1997 Bennett RA, Wilson DM, Wong D, Demple B. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proceedings of the National Academy of Sciences of the United States of America. 94: 7166-9. PMID 9207062 DOI: 10.1073/pnas.94.14.7166  1
1997 Hidalgo E, Ding H, Demple B. Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator Trends in Biochemical Sciences. 22: 207-210. PMID 9204707 DOI: 10.1016/S0968-0004(97)01068-2  1
1997 Hidalgo E, Demple B. Spacing of promoter elements regulates the basal expression of the soxS gene and converts SoxR from a transcriptional activator into a repressor Embo Journal. 16: 1056-1065. PMID 9118944 DOI: 10.1093/emboj/16.5.1056  1
1997 Bradley TM, Hidalgo E, Leautaud V, Ding H, Demple B. Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation. Nucleic Acids Research. 25: 1469-75. PMID 9092651 DOI: 10.1093/nar/25.8.1469  1
1997 Demple B. Study of redox-regulated transcription factors in prokaryotes Methods: a Companion to Methods in Enzymology. 11: 267-278. PMID 9073570 DOI: 10.1006/meth.1996.0421  1
1997 Demple B. EDITORIAL Methods. 11: 265-266. PMID 9073569 DOI: 10.1006/meth.1996.0420  1
1997 Hidalgo E, Ding H, Demple B. Redox signal transduction: Mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form Cell. 88: 121-129. PMID 9019397  1
1997 González-Flecha B, Demple B. Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli Journal of Bacteriology. 179: 382-388. PMID 8990289  1
1996 Ding H, Hidalgo E, Demple B. The redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor Journal of Biological Chemistry. 271: 33173-33175. PMID 8969171 DOI: 10.1074/jbc.271.52.33173  1
1996 Demple B. Redox signaling and gene control in the Escherichia coli soxRS oxidative stress regulon - A review Gene. 179: 53-57. PMID 8955629 DOI: 10.1016/S0378-1119(96)00329-0  1
1996 Li Z, Demple B. Sequence specificity for DNA binding by Escherichia coli SoxS and Rob proteins Molecular Microbiology. 20: 937-945. PMID 8809747 DOI: 10.1111/j.1365-2958.1996.tb02535.x  1
1996 Ding H, Demple B. Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein Proceedings of the National Academy of Sciences of the United States of America. 93: 9449-9453. PMID 8790350 DOI: 10.1073/pnas.93.18.9449  1
1996 Ramotar D, Demple B. Functional expression of Escherichia coli endonuclease IV in apurinic endonuclease-deficient yeast Journal of Biological Chemistry. 271: 7368-7374. PMID 8631759 DOI: 10.1074/jbc.271.13.7368  1
1996 Hidalgo E, Demple B. Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into Apo-SoxR Journal of Biological Chemistry. 271: 7269-7272. PMID 8631739 DOI: 10.1074/jbc.271.13.7269  1
1996 Harrison L, Galanopoulos T, Ascione AG, Antoniades HN, Demple B. Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis Carcinogenesis. 17: 377-381. PMID 8625467  1
1996 Levin JD, Demple B. In vitro detection of endonuclease IV-specific DNA damage formed by bleomycin in vivo. Nucleic Acids Research. 24: 885-9. PMID 8600456 DOI: 10.1093/nar/24.5.885  1
1996 Wilson DM, Takeshita M, Demple B. Abasic Site Binding by the Human Apurinic Endonuclease, Ape, and Determination of the DNA Contact Sites Nucleic Acids Research. 25: 933-939. DOI: 10.1093/nar/25.5.933  1
1995 Willson DM, Bennett RAO, Marquis JC, Ansari P, Demple B. Trans-complementation by human apurinic endonuclease (ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn 1 yeast Nucleic Acids Research. 23: 5027-5033. PMID 8559661 DOI: 10.1093/nar/23.24.5027  1
1995 Ariza RR, Li Z, Ringstad N, Demple B. Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein. Journal of Bacteriology. 177: 1655-61. PMID 7896685  1
1995 Gonzalez-Flecha B, Demple B. Metabolic sources of hydrogen peroxide in aerobically growing Escherichia coli Journal of Biological Chemistry. 270: 13681-13687. PMID 7775420 DOI: 10.1074/jbc.270.23.13681  1
1995 Hidalgo E, Bollinger JM, Bradley TM, Walsh CT, Demple B. Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. The Journal of Biological Chemistry. 270: 20908-14. PMID 7673113 DOI: 10.1074/jbc.270.36.20908  1
1995 Wilson DM, Takeshita M, Grollman AP, Demple B. Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA Journal of Biological Chemistry. 270: 16002-16007. PMID 7608159 DOI: 10.1074/jbc.270.27.16002  1
1995 Demple B. Enzyme Structures: DNA repair flips out Current Biology. 5: 719-721. PMID 7583113 DOI: 10.1016/S0960-9822(95)00143-6  1
1995 Harrison L, Ascione AG, Wilson DM, Demple B. Characterization of the promoter region of the human apurinic endonuclease gene (APE) Journal of Biological Chemistry. 270: 5556-5564. PMID 7534297 DOI: 10.1074/jbc.270.10.5556  1
1995 Nunoshiba T, DeRojas-Walker T, Tannenbaum SR, Demple B. Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages Infection and Immunity. 63: 794-798. PMID 7532626  1
1995 Hughes-Davies L, Galanopoulos T, Harrison L, Maxwell M, Antoniades HN, Demple B. Expression of the human apurinic endonuclease gene (APE) in normal and malignant tissues International Journal of Oncology. 6: 749-752.  1
1994 Hidalgo E, Demple B. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein Embo Journal. 13: 138-146. PMID 8306957  1
1994 Ariza RR, Cohen SP, Bachhawat N, Levy SB, Demple B. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. Journal of Bacteriology. 176: 143-8. PMID 8282690  1
1994 Gonzalez-Flecha B, Demple B. Intracellular generation of superoxide as a by-product of Vibrio harveyi luciferase expressed in Escherichia coli Journal of Bacteriology. 176: 2293-2299. PMID 8157597  1
1994 Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC. Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli. The Embo Journal. 13: 1495-501. PMID 8156986  1
1994 Nunoshiba T, Demple B. A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator Nucleic Acids Research. 22: 2958-2962. PMID 8065907 DOI: 10.1093/nar/22.15.2958  1
1994 Li Z, Demple B. SoxS, an activator of superoxide stress genes in Escherichia coli: Purification and interaction with DNA Journal of Biological Chemistry. 269: 18371-18377. PMID 8034583  1
1994 Demple B, Harrison L. Repair of oxidative damage to DNA: Enzymology and biology Annual Review of Biochemistry. 63: 915-948. PMID 7979257  1
1994 Takeuchi M, Lillis R, Demple B, Takeshita M. Interactions of Escherichia coli endonuclease IV and exonuclease III with abasic sites in DNA Journal of Biological Chemistry. 269: 21907-21914. PMID 7520446  1
1994 Kunz BA, Henson ES, Roche H, Ramotar D, Nunoshiba T, Demple B. Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease Proceedings of the National Academy of Sciences of the United States of America. 91: 8165-8169. PMID 7520176 DOI: 10.1073/pnas.91.17.8165  1
1994 Häring M, Rüdiger H, Demple B, Boiteux S, Epe B. Recognition of oxidized abasic sites by repair endonucleases Nucleic Acids Research. 22: 2010-2015. PMID 7518077 DOI: 10.1093/nar/22.11.2010  1
1993 Nunoshiba T, Demple B. Potent Intracellular Oxidative Stress Exerted by the Carcinogen 4-Nitroquinoline-iV-oxide Cancer Research. 53: 3250-3252. PMID 8391920  1
1993 Nunoshiba T, DeRojas-Walker T, Wishnok JS, Tannenbaum SR, Demple B. Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages Proceedings of the National Academy of Sciences of the United States of America. 90: 9993-9997. PMID 8234347 DOI: 10.1073/pnas.90.21.9993  1
1993 Nunoshiba T, Hidalgo E, Li Z, Demple B. Negative autoregulation by the Escherichia coli SoxS protein: A dampening mechanism for the soxRS redox stress response Journal of Bacteriology. 175: 7492-7494. PMID 8226698  1
1993 Ramotar D, Kim C, Lillis R, Demple B. Intracellular localization of the Apnl DNA repair enzyme of Saccharomyces cerevisiae: Nuclear transport signals and biological role Journal of Biological Chemistry. 268: 20533-20539. PMID 7690756  1
1993 Chou JH, Greenberg JT, Demple B. Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: Positive control of the micF antisense RNA by the soxRS locus Journal of Bacteriology. 175: 1026-1031. PMID 7679383  1
1992 Nunoshiba T, Hidalgo E, Cuevas CFA, Demple B. Two-stage control of an oxidative stress regulon: The Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene Journal of Bacteriology. 174: 6054-6060. PMID 1400156  1
1992 Harrison L, Ascione G, Menninger JC, Ward DC, Demple B. Human apurinic endonuclease gene (APE): Structure and genomic mapping (chromosome 1 4q11.2 - 12) Human Molecular Genetics. 1: 677-680. PMID 1284593 DOI: 10.1093/hmg/1.9.677  1
1991 Demple B, Herman T, Chen DS. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: Definition of a family of DNA repair enzymes Proceedings of the National Academy of Sciences of the United States of America. 88: 11450-11454. PMID 1722334  1
1991 Levin JD, Shapiro R, Demple B. Metalloenzymes in DNA repair. Escherichia coli endonuclease IV and Saccharomyces cerevisiae Apn1. The Journal of Biological Chemistry. 266: 22893-8. PMID 1720775  1
1991 Chen DS, Herman T, Demple B. Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA Nucleic Acids Research. 19: 5907-5914. PMID 1719484 DOI: 10.1093/nar/19.21.5907  1
1991 Ramotar D, Popoff SC, Gralla EB, Demple B. Cellular role of yeast Apn1 apurinic endonuclease/3′-diesterase: Repair of oxidative and alkylation DNA damage and control of spontaneous mutation Molecular and Cellular Biology. 11: 4537-4544. PMID 1715020  1
1991 Ramotar D, Popoff SC, Demple B. Complementation of DNA repair-deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease gene Molecular Microbiology. 5: 149-155. PMID 1707475  1
1991 Demple B. Regulation of bacterial oxidative stress genes Annual Review of Genetics. 25: 315-337. PMID 1667460  1
1991 Demple B, Amábile-Cuevas CF. Redox redux: The control of oxidative stress responses Cell. 67: 837-839. PMID 1659949  1
1991 Amábile-cuevas CF, Demple B. Molecular characterization of the soxRS genes of Escherichia coli: Two genes control a superoxide stress regulon Nucleic Acids Research. 19: 4479-4484. PMID 1653416 DOI: 10.1093/nar/19.16.4479  1
1991 Greenberg JT, Chou JH, Monach PA, Demple B. Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli Journal of Bacteriology. 173: 4433-4439. PMID 1648558  1
1990 Levin JD, Demple B. Analysis of class II (hydrolytic) and class I (beta-lyase) apurinic/apyrimidinic endonucleases with a synthetic DNA substrate. Nucleic Acids Research. 18: 5069-75. PMID 1698278 DOI: 10.1093/nar/18.17.5069  1
1990 Demple B. Oxidative DNA damage: repair and inducible cellular responses Progress in Clinical and Biological Research. 340: 155-167. PMID 1697072  1
1990 Greenberg JT, Monach P, Chou JH, Josephy PD, Demple B. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 87: 6181-5. PMID 1696718  1
1990 Popoff BC, Spira AI, Johnson AW, Demple B. Yeast structural gene (APN1) for the major apurinic endonuclease: Homology to Escherichia coli endonuclease IV Proceedings of the National Academy of Sciences of the United States of America. 87: 4193-4197. PMID 1693433  1
1989 Couto LB, Chaudhuri I, Donahue BA, Demple B, Essigmann JM. Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis Journal of Bacteriology. 171: 4170-4177. PMID 2666388  1
1989 Greenberg JT, Demple B. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress Journal of Bacteriology. 171: 3933-3939. PMID 2472381  1
1989 Bernelot-Moens C, Demple B. Multiple DNA repair activities for 3'-deoxyribose fragments in Escherichia coli Nucleic Acids Research. 17: 587-600. PMID 2464796 DOI: 10.1093/nar/17.2.587  1
1988 Shevell DE, Abou-Zamzam AM, Demple B, Walker GC. Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA Journal of Bacteriology. 170: 3294-3296. PMID 3290202  1
1988 Johnson AW, Demple B. Yeast DNA 3'-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: substrate specificity and kinetics Journal of Biological Chemistry. 263: 18017-18022. PMID 3056936  1
1988 Johnson AW, Demple B. Yeast DNA diesterase for 3'-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage Journal of Biological Chemistry. 263: 18009-18016. PMID 3056935  1
1988 Moody PCE, Demple B. Crystallization of O6-methylguanine-DNA methyltransferase from Escherichia coli Journal of Molecular Biology. 200: 751-752. PMID 3045327 DOI: 10.1016/0022-2836(88)90488-3  1
1988 Greenberg JT, Demple B. Overproduction of peroxide-scavenging enzymes in Escherichia coli suppresses spontaneous mutagenesis and sensitivity to redox-cycling agents in oxyR-mutants Embo Journal. 7: 2611-2617. PMID 2847922  1
1988 Yi TM, Stearns D, Demple B. Illegitimate recombination in an Escherichia coli plasmid: modulation by DNA damage and a new bacterial gene Journal of Bacteriology. 170: 2898-2903. PMID 2838451  1
1988 Levin JD, Johnson AW, Demple B. Homogeneous Escherichia coli endonuclease IV. Characterization of an enzyme that recognizes oxidative damage in DNA. The Journal of Biological Chemistry. 263: 8066-71. PMID 2453510  1
1987 Demple B. Adaptive responses to genotoxic damage: bacterial strategies to prevent mutation and cell death Bioessays. 6: 157-160. PMID 3593325  1
1986 Greenberg JT, Demple B. Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation Journal of Bacteriology. 168: 1026-1029. PMID 3536846  1
1986 Demple B, Daikh Y, Greenberg J, Johnson A. Alkylation and oxidative damages to DNA: constitutive and inducible repair systems Basic Life Sciences. 39: 205-217. PMID 3533043  1
1986 Demple B. Mutant Escherichia coli ada proteins simultaneously defective in the repair of O6-metbylguanine and in gene activation Nucleic Acids Research. 14: 5575-5589. PMID 3526284 DOI: 10.1093/nar/14.14.5575  1
1986 Demple B, Johnson A, Fung D. Exonuclease III and endonuclease IV remove 3' blocks from DNA synthesis primers in H2O2-damaged Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 83: 7731-7735. PMID 2429316  1
1985 Demple B, Sedgwick B, Robins P, Totty N, Waterfield MD, Lindahl T. Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis Proceedings of the National Academy of Sciences of the United States of America. 82: 2688-2692. PMID 3887409 DOI: 10.1073/pnas.82.9.2688  1
1984 Teo I, Sedgwick B, Demple B, Li B, Lindahl T. Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage. The Embo Journal. 3: 2151-7. PMID 6092060  1
1983 Demple B, Halbrook J. Inducible repair of oxidative DNA damage in Escherichia coli Nature. 304: 466-468. PMID 6348554 DOI: 10.1038/304466a0  1
1983 Demple B, Halbrook J, Linn S. Escherichia coli xth mutants are hypersensitive to hydrogen peroxide Journal of Bacteriology. 153: 1079-1082. PMID 6337115  1
1983 Demple B, Karran P. Death of an enzyme: suicide repair of DNA Trends in Biochemical Sciences. 8: 137-139. DOI: 10.1016/0968-0004(83)90238-4  1
1982 Demple B, Linn S. 5,6-saturated thymine lesions in DNA: Production by ultraviolet light or hydrogen peroxide Nucleic Acids Research. 10: 3781-3789. PMID 7111022 DOI: 10.1093/nar/10.12.3781  1
1982 Lindahl T, Karran P, Demple B, Sedgwick B, Harris A. Inducible DNA repair enzymes involved in the adaptive response to alkylating agents Biochimie. 64: 581-583. PMID 6814505 DOI: 10.1016/S0300-9084(82)80091-6  1
1982 Infante AA, Demple B, Chaires JB. Analysis of the Escherichia coli ribosome-ribosomal subunit equilibrium using pressure-induced dissociation Journal of Biological Chemistry. 257: 80-87. PMID 6796592  1
1982 Lindahl T, Demple B, Robins P. Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase Embo Journal. 1: 1359-1363. PMID 6765195  1
1982 Demple B, Jacobsson A, Olsson M, Robins P, Lindahl T. Repair of alkylated DNA in Escherichia coli. Physical properties of O 6-methylguanine-DNA methyltransferase Journal of Biological Chemistry. 257: 13776-13780. PMID 6754717  1
1982 Demple B, Linn S. On the recognition and cleavage mechanism of Escherichia coli endodeoxyribonuclease V, a possible DNA repair enzyme Journal of Biological Chemistry. 257: 2848-2855. PMID 6277916  1
1980 Warner HR, Demple BF, Deutsch WA, Kane CM, Linn S. Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA Proceedings of the National Academy of Sciences of the United States of America. 77: 4602-4606. PMID 6254032  1
1980 Demple B, Linn S. DNA N-glycosylases and UV repair Nature. 287: 203-208. PMID 6253795 DOI: 10.1038/287203a0  1
1980 Demple B, Gates FT, Linn S. [29] Purification and properties of Escherichia coli endodeoxyribonuclease V Methods in Enzymology. 65: 224-231. PMID 6246346 DOI: 10.1016/S0076-6879(80)65031-9  1
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