John M. Littleton - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Pharmacology, Neuroscience Biology, Biochemistry

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Khan MA, Fugate M, Rogers DT, Sambi J, Littleton JM, Rankin SE, Knutson BL. Mechanism of Mesoporous Silica Nanoparticle Interaction with Hairy Root Cultures during Nanoharvesting of Biomolecules. Advanced Biology. 5: e2000173. PMID 33729698 DOI: 10.1002/adbi.202000173  0.36
2020 Khan MA, Wallace WT, Sambi J, Rogers DT, Littleton JM, Rankin SE, Knutson BL. Nanoharvesting of bioactive materials from living plant cultures using engineered silica nanoparticles. Materials Science & Engineering. C, Materials For Biological Applications. 106: 110190. PMID 31753369 DOI: 10.1016/J.Msec.2019.110190  0.36
2019 Kelley ZD, Rogers DT, Littleton JM, Lynn BC. Microfluidic capillary zone electrophoresis mass spectrometry analysis of alkaloids in Lobelia cardinalis transgenic and mutant plant cell cultures. Electrophoresis. PMID 31475363 DOI: 10.1002/elps.201900220  0.36
2016 Brown DP, Rogers DT, Gunjan SK, Gerhardt GA, Littleton JM. Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells. Journal of Biotechnology. PMID 27637316 DOI: 10.1016/j.jbiotec.2016.09.007  0.52
2016 Brown DP, Rogers DT, Pomerleau F, Siripurapu KB, Kulshrestha M, Gerhardt GA, Littleton JM. Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis. Fitoterapia. PMID 27105955 DOI: 10.1016/j.fitote.2016.04.013  0.52
2016 Barron S, Hawkey A, Fields L, Littleton JM. Animal Models for Medication Development and Application to Treat Fetal Alcohol Effects International Review of Neurobiology. DOI: 10.1016/bs.irn.2016.02.002  0.52
2015 Lutz JA, Carter M, Fields L, Barron S, Littleton JM. The Dietary Flavonoid Rhamnetin Inhibits Both Inflammation and Excitotoxicity During Ethanol Withdrawal in Rat Organotypic Hippocampal Slice Cultures. Alcoholism, Clinical and Experimental Research. PMID 26577991 DOI: 10.1111/acer.12896  0.52
2015 Lutz JA, Carter M, Fields L, Barron S, Littleton JM. Altered relation between lipopolysaccharide-induced inflammatory response and excitotoxicity in rat organotypic hippocampal slice cultures during ethanol withdrawal. Alcoholism, Clinical and Experimental Research. 39: 827-35. PMID 25845566 DOI: 10.1111/acer.12705  0.52
2015 Gunjan SK, Rogers DT, Zhang J, Yun KY, Falcone DL, Littleton J. Use of Alpha-, Beta-Estrogen Receptor as a “New Tool” for Detection of Specific Small Molecule Activity Plant Molecular Biology Reporter. DOI: 10.1007/s11105-015-0879-5  0.52
2014 Lutz JA, Kulshrestha M, Rogers DT, Littleton JM. A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia. Fitoterapia. 98: 11-21. PMID 24972350 DOI: 10.1016/j.fitote.2014.06.012  0.52
2013 Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorganic & Medicinal Chemistry. 21: 1764-74. PMID 23465801 DOI: 10.1016/j.bmc.2013.01.051  0.52
2011 Monks NR, Li B, Gunjan S, Rogers DT, Kulshrestha M, Falcone DL, Littleton JM. Natural Products Genomics: A novel approach for the discovery of anti-cancer therapeutics. Journal of Pharmacological and Toxicological Methods. 64: 217-25. PMID 21539926 DOI: 10.1016/j.vascn.2011.04.002  0.52
2010 D'Souza El-Guindy NB, Kovacs EJ, De Witte P, Spies C, Littleton JM, de Villiers WJ, Lott AJ, Plackett TP, Lanzke N, Meadows GG. Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model. Alcoholism, Clinical and Experimental Research. 34: 1489-511. PMID 20586763 DOI: 10.1111/J.1530-0277.2010.01234.X  0.52
2010 Sachan N, Rogers DT, Yun KY, Littleton JM, Falcone DL. Reactive oxygen species regulate alkaloid metabolism in undifferentiated N. tabacum cells. Plant Cell Reports. 29: 437-48. PMID 20217418 DOI: 10.1007/s00299-010-0833-9  0.52
2010 Butler TR, Self RL, Smith KJ, Sharrett-Field LJ, Berry JN, Littleton JM, Pauly JR, Mulholland PJ, Prendergast MA. Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience. 165: 525-34. PMID 19837138 DOI: 10.1016/J.Neuroscience.2009.10.018  0.52
2009 Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice. Pharmacology. 83: 379-84. PMID 19468256 DOI: 10.1159/000219488  0.52
2009 Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiology & Behavior. 97: 503-6. PMID 19268674 DOI: 10.1016/j.physbeh.2009.02.031  0.52
2009 Rubin MA, Wellmann KA, Lewis B, Overgaauw BJ, Littleton JM, Barron S. Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats. Pharmacology, Biochemistry, and Behavior. 92: 44-50. PMID 18992275 DOI: 10.1016/j.pbb.2008.10.008  0.52
2009 Farook JM, Lewis B, Littleton JM, Barron S. Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice. Physiology & Behavior. 96: 189-93. PMID 18786555 DOI: 10.1016/j.physbeh.2008.08.011  0.52
2008 Stepanyan TD, Farook JM, Kowalski A, Kaplan E, Barron S, Littleton JM. Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine. Alcoholism, Clinical and Experimental Research. 32: 2128-35. PMID 18828800 DOI: 10.1111/j.1530-0277.2008.00801.x  0.52
2008 Farook JM, Krazem A, Lewis B, Morrell DJ, Littleton JM, Barron S. Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. Physiology & Behavior. 95: 267-70. PMID 18577392 DOI: 10.1016/j.physbeh.2008.05.020  0.52
2008 Barron S, Mulholland PJ, Littleton JM, Prendergast MA. Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcoholism, Clinical and Experimental Research. 32: 929-36. PMID 18445110 DOI: 10.1111/j.1530-0277.2008.00649.x  0.52
2007 Littleton JM. Acamprosate in alcohol dependence: implications of a unique mechanism of action. Journal of Addiction Medicine. 1: 115-25. PMID 21768946 DOI: 10.1097/ADM.0b013e318156c26f  0.52
2007 Farook JM, Morrell DJ, Lewis B, Littleton JM, Barron S. Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice. Alcohol and Alcoholism (Oxford, Oxfordshire). 42: 296-300. PMID 17548369 DOI: 10.1093/alcalc/agm047  0.52
2007 Littleton J, Barron S, Prendergast M, Nixon SJ. Smoking kills (alcoholics)! shouldn't we do something about it? Alcohol and Alcoholism (Oxford, Oxfordshire). 42: 167-73. PMID 17526626 DOI: 10.1093/alcalc/agm019  0.52
2007 Smith KJ, Self RL, Butler TR, Mullins MM, Ghayoumi L, Holley RC, Littleton JM, Prendergast MA. Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures. Brain Research. 1157: 74-80. PMID 17524372 DOI: 10.1016/J.Brainres.2007.04.056  0.52
2007 Mello CF, Rubin MA, Sultana R, Barron S, Littleton JM, Butterfield DA. Difluoromethylornithine decreases long-lasting protein oxidation induced by neonatal ethanol exposure in the hippocampus of adolescent rats. Alcoholism, Clinical and Experimental Research. 31: 887-94. PMID 17386069 DOI: 10.1111/J.1530-0277.2007.00369.X  0.52
2007 Littleton J. The future of plant drug discovery Expert Opinion On Drug Discovery. 2: 673-683. DOI: 10.1517/17460441.2.5.673  0.52
2006 Wilkins LH, Prendergast MA, Blanchard J, Holley RC, Chambers ER, Littleton JM. Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes. Alcoholism, Clinical and Experimental Research. 30: 1768-80. PMID 17010144 DOI: 10.1111/J.1530-0277.2006.00210.X  0.52
2006 Mulholland PJ, Self RL, Hensley AK, Little HJ, Littleton JM, Prendergast MA. A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis. Brain Research. 1082: 165-72. PMID 16510135 DOI: 10.1016/j.brainres.2006.01.069  0.52
2005 Littleton J, Rogers T, Falcone D. Novel approaches to plant drug discovery based on high throughput pharmacological screening and genetic manipulation Life Sciences. 78: 467-475. PMID 16274700 DOI: 10.1016/j.lfs.2005.09.013  0.52
2005 Mulholland PJ, Stepanyan TD, Self RL, Hensley AK, Harris BR, Kowalski A, Littleton JM, Prendergast MA. Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures. Neuroscience. 136: 259-67. PMID 16182452 DOI: 10.1016/j.neuroscience.2005.07.043  0.52
2005 Mulholland PJ, Self RL, Stepanyan TD, Little HJ, Littleton JM, Prendergast MA. Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro. Neuroscience. 135: 1129-39. PMID 16165302 DOI: 10.1016/j.neuroscience.2005.06.077  0.52
2005 Mulholland PJ, Self RL, Harris BR, Little HJ, Littleton JM, Prendergast MA. Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures. Alcoholism, Clinical and Experimental Research. 29: 871-81. PMID 15897733 DOI: 10.1097/01.ALC.0000163509.27577.DA  0.52
2004 Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA. Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus. Brain Research. Developmental Brain Research. 153: 203-11. PMID 15527888 DOI: 10.1016/j.devbrainres.2004.08.008  0.52
2004 Littleton JM, De Witte P, Litten R, Gessa GL, Spanagel R, Kranzler H, Lehert P, Johnson B, Saunders J, Berglund M, Harris A, Anton R, Mann K. Challenges to medications development in treating alcohol dependence: an international perspective. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 271-5. PMID 15208155 DOI: 10.1093/Alcalc/Agh067  0.52
2004 Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA. (-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity. Neuroscience. 125: 671-82. PMID 15099681 DOI: 10.1016/j.neuroscience.2004.02.007  0.52
2004 Prendergast MA, Harris BR, Mullholland PJ, Blanchard JA, Gibson DA, Holley RC, Littleton JM. Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors. Neuroscience. 124: 869-77. PMID 15026127 DOI: 10.1016/j.neuroscience.2003.12.013  0.52
2004 Rogers DT, Barron S, Littleton JM. Neonatal ethanol exposure produces a hyperalgesia that extends into adolescence, and is associated with increased analgesic and rewarding properties of nicotine in rats. Psychopharmacology. 171: 204-11. PMID 13680078 DOI: 10.1007/s00213-003-1574-z  0.52
2003 Littleton J, Zieglgänsberger W. Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. 12: S3-11. PMID 14972776 DOI: 10.1111/j.1521-0391.2003.tb00492.x  0.52
2003 Harris BR, Gibson DA, Prendergast MA, Blanchard JA, Holley RC, Hart SR, Scotland RL, Foster TC, Pedigo NW, Littleton JM. The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors. Alcoholism, Clinical and Experimental Research. 27: 1724-35. PMID 14634487 DOI: 10.1097/01.ALC.0000093601.33119.E3  0.52
2003 Mulholland PJ, Harris BR, Wilkins LH, Self RL, Blanchard JA, Holley RC, Littleton JM, Prendergast MA. Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression. Alcohol (Fayetteville, N.Y.). 31: 1-10. PMID 14615005 DOI: 10.1016/J.Alcohol.2003.09.001  0.52
2003 Gibson DA, Harris BR, Prendergast MA, Hart SR, Blanchard JA, Holley RC, Pedigo NW, Littleton JM. Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor. Alcoholism, Clinical and Experimental Research. 27: 1099-106. PMID 12878916 DOI: 10.1097/01.ALC.0000075824.10502.DD  0.52
2002 Prendergast MA, Rogers DT, Barron S, Bardo MT, Littleton JM. Ethanol and nicotine: a pharmacologic balancing act? Alcoholism, Clinical and Experimental Research. 26: 1917-8. PMID 12500119 DOI: 10.1097/01.ALC.0000040846.27378.80  0.52
2002 Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, Fu MC, Hart SR, Pedigo NW, Littleton JM. Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcoholism, Clinical and Experimental Research. 26: 1779-93. PMID 12500101 DOI: 10.1097/01.ALC.0000042011.99580.98  0.52
2002 Prendergast MA, Rogers DT, Mulholland PJ, Littleton JM, Wilkins LH, Self RL, Nath A. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Research. 954: 300-7. PMID 12414113 DOI: 10.1016/S0006-8993(02)03360-7  0.52
2002 Gibson DA, Harris BR, Rogers DT, Littleton JM. Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain Research. 952: 71-7. PMID 12363406 DOI: 10.1016/S0006-8993(02)03198-0  0.52
2001 Prendergast MA, Harris BR, Mayer S, Holley RC, Pauly JR, Littleton JM. Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 7: 1153-60. PMID 11687723  0.52
2001 Littleton JM, Lovinger D, Liljequist S, Ticku R, Matsumoto I, Barron S. Role of polyamines and NMDA receptors in ethanol dependence and withdrawal Alcoholism: Clinical and Experimental Research. 25. PMID 11391062  0.52
2001 Prendergast MA, Harris BR, Mayer S, Holley RC, Hauser KF, Littleton JM. Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression. Neuroscience. 102: 75-85. PMID 11226671 DOI: 10.1016/S0306-4522(00)00450-4  0.52
2001 Littleton J. Receptor regulation as a unitary mechanism for drug tolerance and physical dependence - Not quite as simple as it seemed! Addiction. 96: 87-101. PMID 11177522 DOI: 10.1046/j.1360-0443.2001.961877.x  0.52
2001 Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Research. 890: 343-6. PMID 11164802 DOI: 10.1016/S0006-8993(00)03201-7  0.52
2000 Prendergast MA, Harris BR, Blanchard JA, Mayer S, Gibson DA, Littleton JM. In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat. Alcoholism, Clinical and Experimental Research. 24: 1855-61. PMID 11141045  0.52
2000 Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorganic & Medicinal Chemistry Letters. 10: 2621-3. PMID 11128637 DOI: 10.1016/S0960-894X(00)00530-8  0.52
2000 Prendergast MA, Harris BR, Mayer S, Littleton JM. Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro. Alcoholism, Clinical and Experimental Research. 24: 1583-92. PMID 11045868  0.52
2000 Cole JC, Littleton JM, Little HJ. Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology. 147: 403-11. PMID 10672634  0.52
2000 Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Dapsone analogs as potential polyamine binding site modulators of the N-methyl-D-aspartate receptor complex Drug Development Research. 51: 268-272. DOI: 10.1002/ddr.8  0.52
1999 Guppy LJ, Littleton JM. Damaging effects of the calcium paradox are reduced in isolated hearts from ethanol-dependent rats: Paradoxic effects of dihydropyridine drugs Journal of Cardiovascular Pharmacology. 34: 765-771. PMID 10598118 DOI: 10.1097/00005344-199912000-00001  0.52
1999 Guppy LJ, Littleton JM. Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: Apparent protection by nitrendipine Journal of Cardiovascular Pharmacology. 34: 628-634. PMID 10547077 DOI: 10.1097/00005344-199911000-00002  0.52
1999 Guppy LJ, Littleton JM. Effect of calcium, Bay K 8644, and reduced perfusion on basic indices of myocardial function in isolated hearts from rats after prolonged exposure to ethanol Journal of Cardiovascular Pharmacology. 34: 480-487. PMID 10511121 DOI: 10.1097/00005344-199910000-00002  0.52
1999 Guppy LJ, Littleton JM. Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart Journal of Cardiovascular Pharmacology. 34: 414-419. PMID 10471001 DOI: 10.1097/00005344-199909000-00015  0.52
1999 Cole JC, Littleton JM, Little HJ. Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour. Psychopharmacology. 142: 270-9. PMID 10208319 DOI: 10.1007/s002130050889  0.52
1998 Bouchenafa O, Littleton JM. Expression of c-Fos protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine Alcohol. 15: 71-76. PMID 9426840 DOI: 10.1016/S0741-8329(97)00100-6  0.52
1996 Becker HC. The alcohol withdrawal "kindling" phenomenon: clinical and experimental findings. Alcoholism, Clinical and Experimental Research. 20: 121A-124A. PMID 8947249 DOI: 10.1111/J.1530-0277.1996.Tb01760.X  0.52
1995 Guppy LJ, Crabbe JC, Littleton JM. Time course and genetic variation in the regulation of calcium channel antagonist binding sites in rodent tissues during the induction of ethanol physical dependence and withdrawal. Alcohol and Alcoholism (Oxford, Oxfordshire). 30: 607-15. PMID 8554643  0.52
1995 Littleton J. Acamprosate in alcohol dependence: How does it work? Addiction. 90: 1179-1188. PMID 7580816 DOI: 10.1046/j.1360-0443.1995.90911793.x  0.52
1995 Guppy LJ, Littleton JM. Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats Proceedings of the Western Pharmacology Society. 38: 73-75. PMID 7480028  0.52
1994 Ruhe CA, Littleton JM. The possible role of voltage-operated calcium channels in the enhancement of excitatory amino acid toxicity following chronic ethanol exposure in vitro Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement.. 2: 217-221. PMID 8974339  0.52
1994 Guppy LJ, Littleton JM. The time course of up-regulation and down-regulation of dihydropyridine binding sites during the development of physical dependence on ethanol Proceedings of the Western Pharmacology Society. 37: 77-80. PMID 7984679  0.52
1994 Guppy LJ, Littleton JM. Binding characteristics of the calcium channel antagonist [3h]-nitrendipine in tissues from ethanol-dependent rats Alcohol and Alcoholism. 29: 283-293. PMID 7945569  0.52
1994 Littleton J, Little H. Current concepts of ethanol dependence. Addiction (Abingdon, England). 89: 1397-412. PMID 7841849 DOI: 10.1111/j.1360-0443.1994.tb03736.x  0.52
1992 Littleton J, Little H, Laverty R. Role of neuronal calcium channels in ethanol dependence: from cell cultures to the intact animal. Annals of the New York Academy of Sciences. 654: 324-34. PMID 1321573 DOI: 10.1111/j.1749-6632.1992.tb25978.x  0.52
1991 Littleton JM, Brennan C, Bouchenafa O. The role of calcium flux in the central nervous system actions of ethanol Annals of the New York Academy of Sciences. 625: 388-394. PMID 2058895  0.52
1991 Brennan CH, Littleton JM. Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells Neuropharmacology. 30: 199-205. PMID 1674364 DOI: 10.1016/0028-3908(91)90204-O  0.52
1991 Harper JC, Littleton JM. Characteristics of catecholamine release from adrenal chromaffin cells cultured in medium containing ethanol - II. Carbachol and veratrine-induced release Alcohol and Alcoholism. 26: 33-38. PMID 1649608  0.52
1991 Harper JC, Littleton JM. Characteristics of catecholamine release from adrenal chromaffin cells cultured in medium containing ethanol - I. Spontaneous and K+-induced release Alcohol and Alcoholism. 26: 25-32. PMID 1649607  0.52
1990 Brennan CH, Crabbe J, Littleton JM. Genetic regulation of dihydropyridine-sensitive calcium channels in brain may determine susceptibility to physical dependence on alcohol Neuropharmacology. 29: 429-432. PMID 2162493 DOI: 10.1016/0028-3908(90)90163-L  0.52
1990 Harper JC, Littleton JM. Development of tolerance to ethanol in cultured adrenal chromaffin cells Alcoholism: Clinical and Experimental Research. 14: 508-512. PMID 1699441 DOI: 10.1111/j.1530-0277.1990.tb01189.x  0.52
1990 Brennan CH, Littleton JM. Second messengers involved in genetic regulation of the number of calcium channels in bovine adrenal chromaffin cells in culture Neuropharmacology. 29: 689-693. PMID 1696702 DOI: 10.1016/0028-3908(90)90031-L  0.52
1990 Littleton JM, Little HJ, Whittington MA. Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644. Psychopharmacology. 100: 387-92. PMID 1690434 DOI: 10.1007/Bf02244612  0.52
1989 Brennan CH, Lewis A, Littleton JM. Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol Neuropharmacology. 28: 1303-1307. PMID 2482458 DOI: 10.1016/0028-3908(89)90003-8  0.52
1989 Harper JC, Brennan CH, Littleton JM. Genetic up-regulation of calcium channels in a cellular model of ethanol dependence Neuropharmacology. 28: 1299-1302. PMID 2482457 DOI: 10.1016/0028-3908(89)90002-6  0.52
1989 Brennan CH, Guppy LJ, Littleton JM. Chronic exposure to ethanol increases dihydropyridine-sensitive calcium channels in excitable cells Annals of the New York Academy of Sciences. 560: 467-469.  0.52
1988 Littleton JM. Alcohol-induced alterations in calcium handling Biochemical Society Transactions. 16: 527-529. PMID 2850240  0.52
1988 Littleton JM, Little HJ. Dihydropyridine-sensitive Ca2+ channels in brain are involved in the central nervous system hyperexcitability associated with alcohol withdrawal states Annals of the New York Academy of Sciences. 522: 199-202.  0.52
1987 Fawcett J, Caberos LP, Littleton JM. The potentiation of platelet aggregation by mechanical stimuli is inhibited by ethanol in vitro Alcohol and Alcoholism (Oxford, Oxfordshire). 573-576. PMID 3122775  0.52
1987 Harper JC, Pagonis C, Littleton JM. Altered characteristics of catecholamine release from rat cortical slices and bovine adrenal chromaffin cells in cutlure after chronic exposure to ethanol and the effect of the dihydropyridine drugs on these systems Alcohol and Alcoholism. 725-729. PMID 2447907  0.52
1987 Hudspith MJ, Brennan CH, Charles S, Littleton JM. Dihydropyridine-sensitive Ca2+ channels and inositol phospholipid metabolism in ethanol physical dependence Annals of the New York Academy of Sciences. 156-170. PMID 2440359  0.52
1986 Lynch MA, Archer ER, Littleton JM. Increased sensitivity of transmitter release to calcium in ethanol tolerance. Biochemical Pharmacology. 35: 1207-9. PMID 2870715 DOI: 10.1016/0006-2952(86)90164-4  0.52
1985 Lynch MA, Pagonis C, Samuel D, Littleton JM. Alterations in Ca2+-dependent and Ca2+-independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo Alcohol. 2: 139-144. PMID 4015828 DOI: 10.1016/0741-8329(85)90031-X  0.52
1985 Fenn GC, Caberos LP, Littleton JM. Effect of ethanol on thrombin-induced platelet phospholipid breakdown and release of [3H]-5-hydroxytryptamine Alcohol. 2: 177-182. PMID 3925967 DOI: 10.1016/0741-8329(85)90039-4  0.52
1985 John GR, Littleton JM, Nhamburo PT. Increased activity of Ca2+-dependent enzymes of membrane lipid metabolism in synaptosomal preparations from ethanol-dependent rats. Journal of Neurochemistry. 44: 1235-41. PMID 3919159  0.52
1985 Lynch MA, Samuel D, Littleton JM. Altered characteristics of [3H]dopamine release from superfused slices of corpus striatum obtained from rats receiving ethanol in vivo Neuropharmacology. 24: 479-485. PMID 2862601 DOI: 10.1016/0028-3908(85)90052-8  0.52
1985 Hudspith M, John GR, Nhamburo PT, Littleton JM. Effect of ethanol in vitro and in vivo on Ca2+-activated metabolism of membrane phospholipids in rat synaptosomal and brain slice preparations. Alcohol (Fayetteville, N.Y.). 2: 133-8. PMID 2861830 DOI: 10.1016/0741-8329(85)90030-8  0.52
1985 Lynch MA, Littleton JM. Enhanced [3H]-noradrenaline release in synaptosomes from ethanol-tolerant animals: The role of nerve terminal calcium ion concentrations Alcohol and Alcoholism. 20: 5-11. PMID 2409991  0.52
1985 Littleton JM, Pagonis C. Biochemical effects of ethanol on central neurotransmitter function Alcohol and Alcoholism. 20: 77-78.  0.52
1984 Fenn CG, Littleton JM. Interactions between ethanol and dietary fat in determining human platelet function Thrombosis and Haemostasis. 51: 50-53. PMID 6719388  0.52
1983 Anderson RL, Ahier RG, Littleton JM. Observations on the cellular effects of ethanol and hyperthermia in vivo Radiation Research. 94: 318-325. PMID 6856777  0.52
1983 Samuel D, Lynch MA, Littleton JM. Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum Neuropharmacology. 22: 1413-1415. PMID 6664470 DOI: 10.1016/0028-3908(83)90234-4  0.52
1983 Connelly MS, Littleton JM. Lack of stereoselectivity in ability of nicotine to release dopamine from rat synaptosomal preparations Journal of Neurochemistry. 41: 1297-1302. PMID 6619866  0.52
1983 Patrikiou-Caberos L, Lynch MA, Leroy C, Fenn GC, Littleton JM. Interactions of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices Biochemical Pharmacology. 32: 2211-2216. PMID 6409118 DOI: 10.1016/0006-2952(83)90228-9  0.52
1983 Fenn CG, Littleton JM. The human blood platelet as a model for studying interactions of ethanol with membrane lipids Alcoholism: Clinical and Experimental Research. 7: 59-64. PMID 6405649  0.52
1983 Fenn GC, Lynch MA, Nhamburo PT, Caberos L, Littleton JM. Comparison of effects of ethanol on platelet function and synaptic transmission Pharmacology, Biochemistry and Behavior. 18: 37-43. PMID 6314381 DOI: 10.1016/0091-3057(83)90144-2  0.52
1983 Lynch MA, Littleton JM. Possible association of alcohol tolerance with increased synaptic Ca 2+ sensitivity Nature. 303: 175-176. PMID 6302519 DOI: 10.1038/303175a0  0.52
1983 Littleton JM. Tolerance and physical dependence on alcohol at the level of synaptic membranes: A review Journal of the Royal Society of Medicine. 76: 593-601. PMID 6135804  0.52
1983 Littleton JM. Cell-membrane lipids in ethanol-tolerance and -dependence Biochemical Society Transactions. 11: 61-62. PMID 6130998  0.52
1982 Nhamburo PT, John GR, Littleton JM. Alterations in phospholipid methylation in rat brain synaptosomal membranes produced by ethanol in vitro and in vivo. Biochemical Pharmacology. 31: 3936-8. PMID 6891589 DOI: 10.1016/0006-2952(82)90315-X  0.52
1982 Littleton JM, Fenn CG, Umney ND, Yazdanbakhsh M. Effects of ethanol administration on platelet function in the rat Alcoholism: Clinical and Experimental Research. 6: 512-519. PMID 6817656  0.52
1982 Fenn CG, Littleton JM. Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent used and is influenced by platelet lipid composition Thrombosis and Haemostasis. 48: 49-53. PMID 6813995  0.52
1981 Fenn CG, Littleton JM. Inhibition of platelet aggregation by ethanol: The role of plasma and platelet membrane lipids British Journal of Pharmacology. 73.  0.52
1981 John GR, Littleton JM, Nhamburo PT. Ethanol-induced alterations in phospholipid methylation in rat brain synaptosomal membranes British Journal of Pharmacology. 74: 874P-875P.  0.52
1980 John GR, Littleton JM, Jones PA. Membrane lipids and ethanol tolerance in the mouse. The influence of dietary fatty acid composition. Life Sciences. 27: 545-55. PMID 7421411 DOI: 10.1016/0024-3205(80)90303-3  0.52
1980 Littleton JM, Grieve SJ, Griffiths PJ, John GR. Ethanol-induced alteration in membrane phospholipid composition : possible relationship to development of cellular tolerance to ethanol. Advances in Experimental Medicine and Biology. 126: 7-19. PMID 7405706  0.52
1980 Ruiz JS, Littleton JM. Glucocorticoids play an important role in the rapid development of functional tolerance to ethanol Substance and Alcohol Actions/Misuse. 1: 415-422. PMID 7302791  0.52
1980 Littleton JM, John GR, Jones PA, Grieve SJ. The rapid onset of functional tolerance to ethanol - role of different neurotransmitters and synaptosomal membrane lipids Acta Psychiatrica Scandinavica. 62: 137-151.  0.52
1979 Grieve SJ, Griffiths PJ, Littleton JM. Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice Drug and Alcohol Dependence. 4: 77-86. PMID 574447 DOI: 10.1016/0376-8716(79)90042-5  0.52
1979 Littleton JM. Adaptive changes in membrane lipid composition and fluidity as the basis for ethanol tolerance Drug and Alcohol Dependence. 4: 189-195. PMID 510171 DOI: 10.1016/0376-8716(79)90066-8  0.52
1979 Berry CN, Hoult JR, Littleton JM, Moore PK, Umney ND. Nicotine causes prostaglandin efflux from isolated perfused rat lung British Journal of Pharmacology. 66. PMID 454897  0.52
1979 Littleton JM, John GR, Grieve SJ. Alterations in phospholipid composition in ethanol tolerance and dependence. Alcoholism, Clinical and Experimental Research. 3: 50-6. PMID 371451  0.52
1979 Rigby M, Littleton JM. Experimental observations on the relationship between ethanol tolerance and physical dependence British Journal of Addiction. 74: 363-367. PMID 295659  0.52
1979 Griffiths PJ, Murad CA, Littleton JM. Ethanol-induced hepatic triglyceride accumulation in mice and genetic differences in the ethanol physical withdrawal syndrome British Journal of Addiction. 74: 37-42. PMID 283826  0.52
1979 Grieve SJ, Littleton JM, Jones P, John GR. Functional tolerance to ethanol in mice: relationship to lipid metabolism. The Journal of Pharmacy and Pharmacology. 31: 737-42. PMID 41903  0.52
1979 Grieve SJ, Littleton JM. The rapid development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 605-610. PMID 41062  0.52
1979 Grieve SJ, Littleton JM. Ambient temperature and the development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 707-708. PMID 41048  0.52
1979 Grieve SJ, Littleton JM. Age and strain differences in the rate of development of functional tolerance to ethanol by mice Journal of Pharmacy and Pharmacology. 31: 696-700. PMID 41043  0.52
1979 Littleton JM. Cellular tolerance to ethanol as membrane adaptation: A review British Journal On Alcohol and Alcoholism. 14: 23-36.  0.52
1978 Abu Murad C, Littleton JM. Cardiac phospholipid composition during continuous administration of ethanol to mice: effect of vitamin E British Journal of Pharmacology. 63. PMID 667455  0.52
1978 Abu-Murad C, Littleton JM. Alteration in serum tyrosine and tryptophan concentrations associated with the induction of physical dependence on ethanol in mice Biochemical Pharmacology. 27: 1697-1698. PMID 567990 DOI: 10.1016/0006-2952(78)90182-X  0.52
1978 Grieve SJ, Littleton JM. Rapid development of cellular tolerance during continuous administration of ethanol to mice by inhalation British Journal of Pharmacology. 63. PMID 566599  0.52
1978 Littleton J. 7 Alcohol and neurotransmitters Clinics in Endocrinology and Metabolism. 7: 369-384. PMID 28864 DOI: 10.1016/S0300-595X(78)80024-3  0.52
1977 Littleton JM, Umney ND. The chronic administration of l nicotine by aerosol to rats Journal of Physiology. 266. PMID 853385  0.52
1977 MacLean KI, Littleton JM. Environmental stress as a factor in the response of rat brain catecholamine metabolism to Δ8-tetrahydrocannabinol European Journal of Pharmacology. 41: 171-182. PMID 832673 DOI: 10.1016/0014-2999(77)90206-0  0.52
1977 Murad CA, Begg SJ, Griffiths PJ, Littleton JM. Hepatic triglyceride accumulation and the ethanol physical withdrawal syndrome in mice British Journal of Experimental Pathology. 58: 606-615. PMID 564703  0.52
1977 Griffiths PJ, Littleton JM. Concentrations of free amino acids in brains of mice of different strains during the physical syndrome of withdrawal from alcohol British Journal of Experimental Pathology. 58: 391-399. PMID 562175  0.52
1977 Abu Murad C, Begg SJ, Griffiths PJ, Littleton JM. The induction and study of physical dependence on ethanol in mice Journal of Physiology. 266. PMID 558329  0.52
1977 Griffiths PJ, Littleton JM. Concentrations of free amino acids in brains of mice during the induction of physical dependence on ethanol and during the ethanol withdrawal syndrome British Journal of Experimental Pathology. 58: 19-27. PMID 556941  0.52
1977 Littleton JM, John G. Synaptosomal membrane lipids of mice during continuous exposure to ethanol Journal of Pharmacy and Pharmacology. 29: 579-580. PMID 21273 DOI: 10.1111/j.2042-7158.1977.tb11407.x  0.52
1976 Littleton JM, MacLean KI. Alterations in dopamine uptake in rat corpus striatum induced by combinations of stress and Δ8 tetrahydrocannabinol (Δ8 THC) British Journal of Pharmacology. 56. PMID 1260199  0.52
1976 Abu Murad C, Griffiths PJ, Littleton JM. Catecholamine metabolism and liver dysfunction during induction of ethanol dependence British Journal of Pharmacology. 56.  0.52
1975 Littleton JM. The experimental approach to alcoholism British Journal of Addiction. 70: 99-122. PMID 1058027  0.52
1974 Littleton JM, Ryan SM. Proceedings: Hypothermia produced by inhibitors of catecholamine biosynthesis British Journal of Pharmacology. 50. PMID 4853820  0.52
1974 Griffiths PJ, Littleton JM, Ortiz A. Changes in monoamine concentrations in mouse brain associated with ethanol dependence and withdrawal Brit.J.Pharmacol.. 50: 489-498. PMID 4475606  0.52
1974 Littleton JM, Maclean KI. The effect of Δ8 tetrahydrocannabinol (Δ8 THC) on dopamine metabolism in the rat corpus striatum: the influence of environment Brit.J.Pharmacol.. 51: 117. PMID 4441767  0.52
1974 Littleton JM. Letter: Dual mechanism of amphetamine toxicity in mice: relationship to brain catecholamines Acta Pharmacologica Et Toxicologica. 34: 92-96. PMID 4406562  0.52
1974 Griffiths PJ, Littleton JM, Ortiz A. Effect of p chlorophenylalanine on brain monoamines and behaviour during ethanol withdrawal in mice Brit.J.Pharmacol.. 51: 307-309. PMID 4281335  0.52
1974 Ortiz A, Griffiths PJ, Littleton JM. A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence Journal of Pharmacy and Pharmacology. 26: 249-260. PMID 4151380  0.52
1974 Littleton JM, Griffiths PJ, Ortiz A. The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole Journal of Pharmacy and Pharmacology. 26: 81-91. PMID 4150837  0.52
1974 Griffiths PJ, Littleton JM, Ortiz A. Chronic administration of acetaldehyde to mice: behavioural and biochemical similarities with chronic ethanol administration Brit.J.Pharmacol.. 50: 441.  0.52
1973 Griffiths PJ, Littleton JM, Ortiz A. A method for the induction of dependence to ethanol in mice Brit.J.Pharmacol.. 47. PMID 4738387  0.52
1973 Ortiz A, Littleton JM, Griffiths PJ. A simple screening test for drugs of potential use in ethanol withdrawal Journal of Pharmacy and Pharmacology. 25: 1020-1021. PMID 4150293 DOI: 10.1111/j.2042-7158.1973.tb10005.x  0.52
1973 Griffiths PJ, Littleton JM, Ortiz A. Evidence of a role for brain monoamines in ethanol dependence Brit.J.Pharmacol.. 48. PMID 4147432  0.52
1967 Littleton JM. The interaction of dexamphetamine with inhibitors of noradrenaline biosynthesis in rat brain in vivo Journal of Pharmacy and Pharmacology. 19: 414-415. PMID 4382377  0.52
Show low-probability matches.