Mark R. Philips, M.D. - Publications

Affiliations: 
1991- New York University, New York, NY, United States 
Area:
Cell Biology, Biochemistry
Website:
https://www.atthelimits.org/biographies/dr-mark-r-philips/

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. The Journal of Clinical Investigation. 133. PMID 37317963 DOI: 10.1172/JCI165510  0.476
2023 Kochen Rossi J, Nuevo-Tapioles C, Philips MR. Differential functions of the KRAS splice variants. Biochemical Society Transactions. PMID 37222266 DOI: 10.1042/BST20221347  0.412
2023 García-España A, Philips MR. Origin and Evolution of RAS Membrane Targeting. Oncogene. PMID 37031342 DOI: 10.1038/s41388-023-02672-z  0.506
2023 Simanshu DK, Philips MR, Hancock JF. Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions. Molecular Cell. PMID 36990093 DOI: 10.1016/j.molcel.2023.03.008  0.487
2023 Philips M, García-España A. Origin and evolution of RAS oncoprotein membrane targeting. Research Square. PMID 36711820 DOI: 10.21203/rs.3.rs-2485219/v1  0.487
2023 Liang D, Jiang L, Bhat SA, Missiroli S, Perrone M, Lauriola A, Adhikari R, Gudur A, Vasi Z, Ahearn I, Guardavaccaro D, Giorgi C, Philips M, Kuchay S. Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation. Cell Reports. 42: 111999. PMID 36662618 DOI: 10.1016/j.celrep.2023.111999  0.722
2021 Campbell SL, Philips MR. Post-translational modification of RAS proteins. Current Opinion in Structural Biology. 71: 180-192. PMID 34365229 DOI: 10.1016/j.sbi.2021.06.015  0.508
2021 Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, ... ... Philips M, et al. ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nature Cancer. 2: 503-514. PMID 34142094 DOI: 10.1038/s43018-021-00208-6  0.664
2021 Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR. NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Life Science Alliance. 4. PMID 33579760 DOI: 10.26508/lsa.202000972  0.826
2021 Chen X, Yao H, Kashif M, Revêchona G, Eriksson M, Hu J, Wang T, Liu Y, Tüksammel E, Strömblad S, Ahearn IM, Philips MR, Wiel C, Ibrahim MX, Bergo MO. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 10. PMID 33526168 DOI: 10.7554/eLife.63284  0.703
2020 Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Proceedings of the National Academy of Sciences of the United States of America. PMID 33257571 DOI: 10.1073/pnas.2005712117  0.841
2020 Sandigursky S, Philips MR, Mor A. SAP interacts with CD28 to inhibit PD-1 signaling in T lymphocytes. Clinical Immunology (Orlando, Fla.). 217: 108485. PMID 32504780 DOI: 10.1016/J.Clim.2020.108485  0.387
2020 Mahaffety JP, Amendola CR, Chen W, Kimmelman A, Balmain A, Philips MR. Abstract A13: KRAS4A directly regulates hexokinase 1 Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A13  0.512
2019 Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, ... ... Philips MR, et al. KRAS4A directly regulates hexokinase 1. Nature. PMID 31827279 DOI: 10.1038/S41586-019-1832-9  0.801
2019 Kuchay S, Wang H, Marzio A, Jain K, Homer H, Fehrenbacher N, Philips MR, Zheng N, Pagano M. GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase. Nature Structural & Molecular Biology. PMID 31209342 DOI: 10.1038/S41594-019-0249-3  0.338
2019 Marin-Ramos NI, Balabasquer M, Ortega-Nogales FJ, Torrecillas IR, Gil-Ordoñez A, Marcos-Ramiro B, Aguilar-Garrido P, Cushman I, Romero A, Medrano FJ, Gajate C, Mollinedo F, Philips MR, Campillo M, Gallardo M, et al. A potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor improves survival in Ras-driven acute myeloid leukemia. Journal of Medicinal Chemistry. PMID 31181882 DOI: 10.1021/Acs.Jmedchem.9B00145  0.57
2019 Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J. Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30733287 DOI: 10.1073/Pnas.1818880116  0.528
2019 Choi BH, Kou Z, Philips MR, Dai W. Abstract 1791: RADIL regulates RAS downstream signaling Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1791  0.542
2018 Choi BH, Philips MR, Chen Y, Lu L, Dai W. K-Ras lysine-42 is crucial for its signaling, cell migration and invasion. The Journal of Biological Chemistry. PMID 30228186 DOI: 10.1074/Jbc.Ra118.003723  0.518
2018 Choi BH, Chen C, Philips M, Dai W. RAS GTPases are modified by SUMOylation. Oncotarget. 9: 4440-4450. PMID 29435114 DOI: 10.18632/Oncotarget.23269  0.605
2018 Ahearn I, Zhou M, Philips MR. Posttranslational Modifications of RAS Proteins. Cold Spring Harbor Perspectives in Medicine. PMID 29311131 DOI: 10.1101/Cshperspect.A031484  0.851
2018 Choi BH, Chen C, Philips M, Dai W. Abstract 3544: Ras GTPases are modified by SUMOylation Cancer Research. 78: 3544-3544. DOI: 10.1158/1538-7445.Am2018-3544  0.602
2017 Fehrenbacher N, Philips MR. Targeting RAS - will GPR31 deliver us a new path forward? Molecular & Cellular Oncology. 4: e1359228. PMID 29209647 DOI: 10.1080/23723556.2017.1359228  0.543
2017 Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. The Journal of Cell Biology. PMID 29051265 DOI: 10.1083/Jcb.201701053  0.745
2017 Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, ... Philips MR, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science Signaling. 10. PMID 28951536 DOI: 10.1126/Scisignal.Aao3332  0.536
2017 Zhou M, Philips MR. Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells. Journal of Visualized Experiments : Jove. PMID 28872138 DOI: 10.3791/56037  0.579
2017 Fehrenbacher N, Tojal da Silva I, Ramirez C, Zhou Y, Cho KJ, Kuchay S, Shi J, Thomas S, Pagano M, Hancock JF, Bar-Sagi D, Philips MR. The G protein-coupled receptor GPR31 promotes membrane association of KRAS. The Journal of Cell Biology. PMID 28619714 DOI: 10.1083/Jcb.201609096  0.417
2017 Genova T, Grolez GP, Camillo C, Bernardini M, Bokhobza A, Richard E, Scianna M, Lemonnier L, Valdembri D, Munaron L, Philips MR, Mattot V, Serini G, Prevarskaya N, Gkika D, et al. TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1. The Journal of Cell Biology. PMID 28550110 DOI: 10.1083/Jcb.201506024  0.332
2017 Zhou M, Philips MR. Where no Ras has gone before: VPS35 steers N-Ras through the cytosol. Small Gtpases. 1-6. PMID 28129035 DOI: 10.1080/21541248.2016.1263380  0.715
2016 Zhou M, Wiener H, Su W, Zhou Y, Liot C, Ahearn I, Hancock JF, Philips MR. VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking. The Journal of Cell Biology. PMID 27502489 DOI: 10.1083/Jcb.201604061  0.852
2016 Frémin C, Guégan JP, Plutoni C, Mahaffey J, Philips MR, Emery G, Meloche S. ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential Oncogene. DOI: 10.1038/onc.2016.122  0.452
2015 Fabris L, Berton S, Pellizzari I, Segatto I, D'Andrea S, Armenia J, Bomben R, Schiappacassi M, Gattei V, Philips MR, Vecchione A, Belletti B, Baldassarre G. p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability. Proceedings of the National Academy of Sciences of the United States of America. 112: 13916-21. PMID 26512117 DOI: 10.1073/Pnas.1508514112  0.418
2015 Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Rap1 and its effector riam are required for lymphocyte trafficking. Blood. PMID 26324702 DOI: 10.1182/Blood-2015-05-644104  0.752
2015 Philips MR, Der CJ. Seeing is believing: Ras dimers observed in live cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9793-4. PMID 26229079 DOI: 10.1073/Pnas.1511805112  0.59
2015 Cox AD, Der CJ, Philips MR. Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1819-27. PMID 25878363 DOI: 10.1158/1078-0432.Ccr-14-3214  0.607
2015 Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proceedings of the National Academy of Sciences of the United States of America. 112: 779-84. PMID 25561545 DOI: 10.1073/Pnas.1412811112  0.809
2015 Lynch SJ, Snitkin H, Gumper I, Philips MR, Sabatini D, Pellicer A. The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations. Journal of Cellular Physiology. 230: 610-9. PMID 25158650 DOI: 10.1002/Jcp.24779  0.75
2015 Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: Back to the future for anti-RAS drug discovery? Clinical Cancer Research. 21: 1819-1827. DOI: 10.1158/1078-0432.CCR-14-3214  0.472
2014 Tsai FD, Wynne JP, Ahearn IM, Philips MR. Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation. Methods in Molecular Biology (Clifton, N.J.). 1120: 33-41. PMID 24470017 DOI: 10.1007/978-1-62703-791-4_3  0.811
2014 Tsai F, Fehernbacher N, Sung P, Court H, Philips MR. Abstract IA15: Membrane targeting of Ras Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Ia15  0.858
2014 Court H, Philips MR, Bar-Sagi D. The biology of K-Ras signaling pathways in pancreatic cancer Molecular Genetics of Pancreatic Cancer. 83-115. DOI: 10.1007/978-1-4614-6549-2_5  0.412
2013 Sung PJ, Tsai FD, Vais H, Court H, Yang J, Fehrenbacher N, Foskett JK, Philips MR. Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors. Proceedings of the National Academy of Sciences of the United States of America. 110: 20593-8. PMID 24297914 DOI: 10.1073/Pnas.1306431110  0.827
2013 Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. The Journal of Clinical Investigation. 123: 4681-94. PMID 24216479 DOI: 10.1172/Jci65764  0.468
2013 Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discovery. 3: 294-307. PMID 23274911 DOI: 10.1158/2159-8290.Cd-12-0198  0.485
2012 Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. The Journal of Cell Biology. 199: 317-30. PMID 23045549 DOI: 10.1083/Jcb.201201157  0.831
2012 Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/Pnas.1201487109  0.582
2012 Philips MR. Ras hitchhikes on PDE6δ. Nature Cell Biology. 14: 128-9. PMID 22298042 DOI: 10.1038/ncb2429  0.46
2012 Tsai FD, Philips MR. Rac1 gets fattier. The Embo Journal. 31: 517-8. PMID 22293830 DOI: 10.1038/Emboj.2011.481  0.778
2012 Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nature Reviews. Molecular Cell Biology. 13: 39-51. PMID 22189424 DOI: 10.1038/Nrm3255  0.837
2011 Villa CH, Dao T, Ahearn I, Fehrenbacher N, Casey E, Rey DA, Korontsvit T, Zakhaleva V, Batt CA, Philips MR, Scheinberg DA. Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. Acs Nano. 5: 5300-11. PMID 21682329 DOI: 10.1021/Nn200182X  0.696
2011 Philips MR. The perplexing case of the geranylgeranyl transferase-deficient mouse. The Journal of Clinical Investigation. 121: 510-3. PMID 21266773 DOI: 10.1172/Jci45952  0.385
2011 Ahearn IM, Tsai FD, Court H, Zhou M, Jennings BC, Ahmed M, Fehrenbacher N, Linder ME, Philips MR. FKBP12 binds to acylated H-ras and promotes depalmitoylation. Molecular Cell. 41: 173-85. PMID 21255728 DOI: 10.1016/J.Molcel.2011.01.001  0.845
2010 Sung PJ, Rodrigues AB, Kleinberger A, Quatela S, Bach EA, Philips MR. Cytosolic Ras supports eye development in Drosophila. Molecular and Cellular Biology. 30: 5649-57. PMID 20937772 DOI: 10.1128/Mcb.00635-10  0.824
2009 Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. The Biochemical Journal. 424: 153-61. PMID 19723022 DOI: 10.1042/Bj20082377  0.372
2009 Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S. Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. The Journal of Biological Chemistry. 284: 28522-32. PMID 19700408 DOI: 10.1074/Jbc.M109.009514  0.6
2009 Fehrenbacher N, Bar-Sagi D, Philips M. Ras/MAPK signaling from endomembranes. Molecular Oncology. 3: 297-307. PMID 19615955 DOI: 10.1016/J.Molonc.2009.06.004  0.611
2009 Fehrenbacher N, Philips M. Intracellular signaling: peripatetic Ras. Current Biology. 19. PMID 19515353 DOI: 10.1016/J.Cub.2009.04.045  0.6
2009 Mor A, Wynne JP, Ahearn IM, Dustin ML, Du G, Philips MR. Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane. Molecular and Cellular Biology. 29: 3297-306. PMID 19332557 DOI: 10.1128/Mcb.00366-09  0.806
2009 Wright LP, Court H, Mor A, Ahearn IM, Casey PJ, Philips MR. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Molecular and Cellular Biology. 29: 1826-33. PMID 19158273 DOI: 10.1128/Mcb.01719-08  0.815
2008 Inder K, Harding A, Plowman SJ, Philips MR, Parton RG, Hancock JF. Activation of the MAPK module from different spatial locations generates distinct system outputs. Molecular Biology of the Cell. 19: 4776-84. PMID 18784252 DOI: 10.1091/Mbc.E08-04-0407  0.538
2008 Michaelson D, Abidi W, Guardavaccaro D, Zhou M, Ahearn I, Pagano M, Philips MR. Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. The Journal of Cell Biology. 181: 485-96. PMID 18443222 DOI: 10.1083/Jcb.200801047  0.792
2008 Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR. Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Methods in Enzymology. 439: 87-102. PMID 18374158 DOI: 10.1016/S0076-6879(07)00407-7  0.841
2008 Quinlan MP, Quatela SE, Philips MR, Settleman J. Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Molecular and Cellular Biology. 28: 2659-74. PMID 18268007 DOI: 10.1128/Mcb.01661-07  0.833
2007 Mor A, Philips MR, Pillinger MH. The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis. Clinical Immunology (Orlando, Fla.). 125: 215-23. PMID 17913587 DOI: 10.1016/J.Clim.2007.08.008  0.58
2007 Mor A, Dustin ML, Philips MR. Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunological Reviews. 218: 114-25. PMID 17624948 DOI: 10.1111/J.1600-065X.2007.00538.X  0.496
2007 Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nature Cell Biology. 9: 713-9. PMID 17486117 DOI: 10.1038/Ncb1592  0.586
2007 Philips MR, Cox AD. Geranylgeranyltransferase I as a target for anti-cancer drugs. The Journal of Clinical Investigation. 117: 1223-5. PMID 17476354 DOI: 10.1172/Jci32108  0.436
2006 Chang EC, Philips MR. Spatial segregation of Ras signaling: new evidence from fission yeast. Cell Cycle (Georgetown, Tex.). 5: 1936-9. PMID 16931912 DOI: 10.4161/Cc.5.17.3187  0.608
2006 Yeung T, Terebiznik M, Yu L, Silvius J, Abidi WM, Philips M, Levine T, Kapus A, Grinstein S. Receptor activation alters inner surface potential during phagocytosis. Science (New York, N.Y.). 313: 347-51. PMID 16857939 DOI: 10.1126/Science.1129551  0.715
2006 Bivona TG, Quatela S, Philips MR. Analysis of Ras activation in living cells with GFP-RBD. Methods in Enzymology. 407: 128-43. PMID 16757320 DOI: 10.1016/S0076-6879(05)07012-6  0.849
2006 Onken B, Wiener H, Philips MR, Chang EC. Compartmentalized signaling of Ras in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 103: 9045-50. PMID 16754851 DOI: 10.1073/Pnas.0603318103  0.865
2006 Mor A, Philips MR. Compartmentalized Ras/MAPK signaling. Annual Review of Immunology. 24: 771-800. PMID 16551266 DOI: 10.1146/Annurev.Immunol.24.021605.090723  0.605
2006 Wright LP, Philips MR. Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. Journal of Lipid Research. 47: 883-91. PMID 16543601 DOI: 10.1194/Jlr.R600004-Jlr200  0.827
2006 Quatela SE, Philips MR. Ras signaling on the Golgi. Current Opinion in Cell Biology. 18: 162-7. PMID 16488589 DOI: 10.1016/J.Ceb.2006.02.004  0.868
2006 Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, ... ... Philips MR, et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Molecular Cell. 21: 481-93. PMID 16483930 DOI: 10.1016/J.Molcel.2006.01.012  0.814
2006 Michaelson D, Philips M. The use of GFP to localize Rho GTPases in living cells. Methods in Enzymology. 406: 296-315. PMID 16472666 DOI: 10.1016/S0076-6879(06)06022-8  0.42
2006 Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. Journal of Lipid Research. 47: 734-44. PMID 16449762 DOI: 10.1194/Jlr.M500556-Jlr200  0.765
2005 Philips MR. Teaching resources. Imaging signal transduction in living cells with fluorescent proteins. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr28. PMID 16352803 DOI: 10.1126/Stke.3142005Tr28  0.335
2005 Philips MR. Analysis of monomeric GTPases of the Ras and Rho families. Methods (San Diego, Calif.). 37: 129-30. PMID 16289970 DOI: 10.1016/J.Ymeth.2005.05.012  0.478
2005 Bivona TG, Philips MR. Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains. Methods (San Diego, Calif.). 37: 138-45. PMID 16289969 DOI: 10.1016/J.Ymeth.2005.05.022  0.767
2005 Philips MR. Compartmentalized signalling of Ras Biochemical Society Transactions. 33: 657-661. PMID 16042567 DOI: 10.1042/Bst0330657  0.656
2005 Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, Symons M. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene. 24: 7821-9. PMID 16027728 DOI: 10.1038/Sj.Onc.1208909  0.304
2005 Goodwin JS, Drake KR, Rogers C, Wright L, Lippincott-Schwartz J, Philips MR, Kenworthy AK. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. The Journal of Cell Biology. 170: 261-72. PMID 16027222 DOI: 10.1083/Jcb.200502063  0.808
2005 Michaelson D, Ali W, Chiu VK, Bergo M, Silletti J, Wright L, Young SG, Philips M. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Molecular Biology of the Cell. 16: 1606-16. PMID 15659645 DOI: 10.1091/Mbc.E04-11-0960  0.855
2005 Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. The Journal of Biological Chemistry. 280: 11413-21. PMID 15657046 DOI: 10.1074/Jbc.M411521200  0.526
2004 Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. The Journal of Clinical Investigation. 114: 1107-16. PMID 15489958 DOI: 10.1172/Jci22269  0.332
2004 Philips MR. Sef: a MEK/ERK catcher on the Golgi. Molecular Cell. 15: 168-9. PMID 15260967 DOI: 10.1016/J.Molcel.2004.07.003  0.449
2004 Perez de Castro I, Bivona TG, Philips MR, Pellicer A. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Molecular and Cellular Biology. 24: 3485-96. PMID 15060167 DOI: 10.1128/Mcb.24.8.3485-3496.2004  0.75
2004 Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations. The Embo Journal. 23: 1749-60. PMID 15057271 DOI: 10.1038/Sj.Emboj.7600197  0.653
2004 Dustin ML, Bivona TG, Philips MR. Membranes as messengers in T cell adhesion signaling. Nature Immunology. 5: 363-72. PMID 15052266 DOI: 10.1038/Ni1057  0.605
2004 Philips MR. Methotrexate and Ras methylation: a new trick for an old drug? Science's Stke : Signal Transduction Knowledge Environment. 2004: pe13. PMID 15039490 DOI: 10.1126/Stke.2252004Pe13  0.566
2004 Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Molecular Cell. 13: 341-55. PMID 14967142 DOI: 10.1016/S1097-2765(04)00050-4  0.676
2004 Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. The Journal of Cell Biology. 164: 461-70. PMID 14757755 DOI: 10.1083/Jcb.200311093  0.824
2004 Chiu VK, Silletti J, Dinsell V, Wiener H, Loukeris K, Ou G, Philips MR, Pillinger MH. Carboxyl methylation of Ras regulates membrane targeting and effector engagement. The Journal of Biological Chemistry. 279: 7346-52. PMID 14660603 DOI: 10.1074/Jbc.M311602200  0.861
2003 Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP. Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. The Journal of Biological Chemistry. 278: 47038-45. PMID 12970366 DOI: 10.1074/Jbc.M303895200  0.732
2003 Bivona TG, Pérez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 424: 694-8. PMID 12845332 DOI: 10.1038/Nature01806  0.866
2003 Bivona TG, Philips MR. Ras pathway signaling on endomembranes. Current Opinion in Cell Biology. 15: 136-42. PMID 12648668 DOI: 10.1016/S0955-0674(03)00016-4  0.738
2003 Michaelson D, Ahearn I, Bergo M, Young S, Philips M. Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Molecular Biology of the Cell. 13: 3294-302. PMID 12221133 DOI: 10.1091/Mbc.E02-02-0095  0.799
2002 Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 4: 343-50. PMID 11988737 DOI: 10.1038/Ncb783  0.852
2001 Murphy GA, Jillian SA, Michaelson D, Philips MR, D'Eustachio P, Rush MG. Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 12: 157-67. PMID 11306516  0.33
2001 Choy E, Philips M. Green fluorescent protein-tagged Ras proteins for intracellular localization. Methods in Enzymology. 332: 50-64. PMID 11305117 DOI: 10.1016/S0076-6879(01)32191-2  0.57
2001 Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding Journal of Cell Biology. 152: 111-126. PMID 11149925 DOI: 10.1083/Jcb.152.1.111  0.481
2001 Choy E, Philips M. Expression and activity of human prenylcysteine-directed carboxyl methyltransferase. Methods in Enzymology. 325: 101-14. PMID 11036596 DOI: 10.1016/S0076-6879(00)25435-9  0.502
1999 Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 98: 69-80. PMID 10412982 DOI: 10.1016/S0092-8674(00)80607-8  0.763
1998 Pillinger MH, Capodici C, Rosenthal P, Kheterpal N, Hanft S, Philips MR, Weissmann G. Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion Proceedings of the National Academy of Sciences of the United States of America. 95: 14540-14545. PMID 9826736 DOI: 10.1073/Pnas.95.24.14540  0.518
1998 Capodici C, Pillinger MH, Han G, Philips MR, Weissmann G. Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase-dependent pathway Journal of Clinical Investigation. 102: 165-175. PMID 9649570 DOI: 10.1172/Jci592  0.565
1998 Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. The Journal of Biological Chemistry. 273: 15030-4. PMID 9614111 DOI: 10.1074/Jbc.273.24.15030  0.756
1997 Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M, Abramson SB. Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. Journal of Clinical Investigation. 100: 1789-1796. PMID 9312179 DOI: 10.1172/Jci119706  0.345
1997 Buyon JP, Philips MR, Merrill JT, Slade SG, Leszczynska-Piziak J, Abramson SB. Differential phosphorylation of the β 2 integrin CD11b/CD18 in the plasma and specific granule membranes of neutrophils Journal of Leukocyte Biology. 61: 313-321. PMID 9060454 DOI: 10.1002/Jlb.61.3.313  0.356
1996 Pillinger MH, Feoktistov AS, Capodici C, Solitar B, Levy J, Oei TT, Philips MR. Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: Evidence for regulation of cell-cell adhesion Journal of Biological Chemistry. 271: 12049-12056. PMID 8662646 DOI: 10.1074/Jbc.271.20.12049  0.378
1995 Philips MR, Staud R, Pillinger M, Feoktistov A, Volker C, Stock JB, Weissmann G. Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 92: 2283-7. PMID 7892262 DOI: 10.1073/Pnas.92.6.2283  0.479
1995 Pillinger MH, Philips MR, Feoktistov A, Weissmann G. Crosstalk in signal transduction via EP receptors: prostaglandin E1 inhibits chemoattractant-induced mitogen-activated protein kinase activity in human neutrophils Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 311-316. PMID 7732861  0.468
1995 Volker C, Pillinger MH, Philips MR, Stock JB. Prenylcysteine analogs to study function of carboxylmethylation in signal transduction. Methods in Enzymology. 250: 216-25. PMID 7651153 DOI: 10.1016/0076-6879(95)50074-X  0.367
1995 Philips MR, Pillinger MH. Prenylcysteine-directed carboxyl methyltransferase activity in human neutrophil membranes Methods in Enzymology. 256: 49-63. PMID 7476455 DOI: 10.1016/0076-6879(95)56009-2  0.53
1994 Pillinger MH, Volker C, Stock JB, Weissmann G, Philips MR. Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils. The Journal of Biological Chemistry. 269: 1486-92. PMID 8288614  0.613
1994 Abramson SB, Leszczynska-Piziak J, Clancy RM, Philips M, Weissmann G. Inhibition of neutrophil function by aspirin-like drugs (NSAIDS): requirement for assembly of heterotrimeric G proteins in bilayer phospholipid. Biochemical Pharmacology. 47: 563-72. PMID 8117325 DOI: 10.1016/0006-2952(94)90189-9  0.508
1993 Philips MR, Pillinger MH, Staud R, Volker C, Rosenfeld MG, Weissmann G, Stock JB. Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. Science (New York, N.Y.). 259: 977-80. PMID 8438158 DOI: 10.1126/Science.8438158  0.702
1991 Philips MR, Abramson SB, Kolasinski SL, Haines KA, Weissmann G, Rosengeld MG. Low molecular weight GTP-binding proteins in human neutrophil granule membranes Journal of Biological Chemistry. 266: 1289-1298. PMID 1898732  0.558
1990 Haines KA, Reibman J, Callegari PE, Abramson SB, Philips MR, Weissmann G. Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase Journal of Immunology. 144: 4757-4764. PMID 2161879  0.427
1990 Abramson SB, Cherksey B, Gude D, Leszczynska-Piziak J, Philips MR, Blau L, Weissmann G. Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity - Studies in human neutrophils and liposomes Inflammation. 14: 11-30. PMID 2138998 DOI: 10.1007/Bf00914026  0.558
1990 Buyon JP, Slade SG, Reibman J, Abramson SB, Philips MR, Weissmann G, Winchester R. Constitutive and induced phosphorylation of the α- and β-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions Journal of Immunology. 144: 191-197. PMID 1967263  0.4
1988 Buyon JP, Abramson SB, Philips MR, Slade SG, Ross GD, Weissmann G, Winchester RJ. Dissociation between increased surface expression of Gp165/95 and homotypic neutrophil aggregation Journal of Immunology. 140: 3156-3160. PMID 3283242  0.385
1988 Hopkins P, Belmont HM, Buyon J, Philips M, Weissmann G, Abramson SB. Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis. Arthritis and Rheumatism. 31: 632-41. PMID 3259882 DOI: 10.1002/Art.1780310508  0.441
1988 Philips MR, Buyon JP, Winchester R, Weissmann G, Abramson SB. Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation Journal of Clinical Investigation. 82: 495-501. PMID 2841354 DOI: 10.1172/Jci113623  0.456
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