Ajit P. Varki - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, Organic Chemistry, Biochemistry

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Khan N, de Manuel M, Peyregne S, Do R, Prufer K, Marques-Bonet T, Varki N, Gagneux P, Varki A. Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins. Genome Biology and Evolution. PMID 32556248 DOI: 10.1093/Gbe/Evaa125  0.44
2020 Gulati S, Schoenhofen IC, Lindhout-Djukic T, Schur MJ, Landig CS, Saha S, Deng L, Lewis LA, Zheng B, Varki A, Ram S. Therapeutic CMP-Nonulosonates against Multidrug-Resistant . Journal of Immunology (Baltimore, Md. : 1950). PMID 32434942 DOI: 10.4049/Jimmunol.1901398  0.36
2019 Khan N, Kim SK, Gagneux P, Dugan LL, Varki A. Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907986 DOI: 10.1096/Fj.201902116R  0.44
2019 Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V. Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. Journal of Innate Immunity. 1-11. PMID 31805552 DOI: 10.1159/000504323  0.4
2019 Zaramela LS, Martino C, Alisson-Silva F, Rees SD, Diaz SL, Chuzel L, Ganatra MB, Taron CH, Secrest P, Zuñiga C, Huang J, Siegel D, Chang G, Varki A, Zengler K. Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. Nature Microbiology. PMID 31548686 DOI: 10.1038/S41564-019-0564-9  0.4
2019 Saha S, Siddiqui SS, Khan N, Verhagen A, Jiang W, Springer S, Ghosh P, Varki A. Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant. Acta Neuropathologica. PMID 31440824 DOI: 10.1007/S00401-019-02065-1  0.44
2019 Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V. Dual actions of group B capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proceedings of the National Academy of Sciences of the United States of America. PMID 30910970 DOI: 10.1073/Pnas.1815572116  0.4
2019 Lu N, Ye J, Cheng J, Sasmal A, Liu CC, Yao W, Yan J, Khan N, Yi W, Varki A, Cao H. Redox-Controlled Site-Specific α2‒6-Sialylation. Journal of the American Chemical Society. PMID 30843692 DOI: 10.1021/Jacs.9B00044  0.44
2019 Landig CS, Hazel A, Kellman BP, Fong JJ, Schwarz F, Agarwal S, Varki N, Massari P, Lewis NE, Ram S, Varki A. Evolution of the exclusively human pathogen : Human-specific engagement of immunoregulatory Siglecs. Evolutionary Applications. 12: 337-349. PMID 30697344 DOI: 10.1111/Eva.12744  0.4
2018 Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD. Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30254166 DOI: 10.1073/Pnas.1804108115  0.4
2018 Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proceedings. Biological Sciences. 285. PMID 30209232 DOI: 10.1098/Rspb.2018.1656  0.64
2018 Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. Plos Pathogens. 14: e1007133. PMID 29912959 DOI: 10.1371/Journal.Ppat.1007133  0.4
2018 Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, ... Varki A, et al. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. Plos One. 13: e0197464. PMID 29912879 DOI: 10.1371/Journal.Pone.0197464  0.4
2018 Cao H, Meng C, Sasmal A, Zhang Y, Gao T, Liu CC, Khan N, Varki A, Wang F. Chemoenzymatic assembly of mammalian O-mannose glycans. Angewandte Chemie (International Ed. in English). PMID 29802667 DOI: 10.1002/Anie.201804373  0.44
2017 Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. Bmc Evolutionary Biology. 17: 228. PMID 29169316 DOI: 10.1186/S12862-017-1075-Z  0.4
2017 Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. Author Correction: Evolution of host adaptation in the Salmonella typhoid toxin. Nature Microbiology. PMID 29093550 DOI: 10.1038/S41564-017-0070-X  0.4
2017 Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. Evolution of host adaptation in the Salmonella typhoid toxin. Nature Microbiology. PMID 28993610 DOI: 10.1038/S41564-017-0033-2  0.4
2017 Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A. N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils. Proceedings of the National Academy of Sciences of the United States of America. PMID 28893995 DOI: 10.1073/Pnas.1706306114  0.4
2017 Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunology and Cell Biology. PMID 28829050 DOI: 10.1038/Icb.2017.63  0.4
2017 Graustein AD, Horne DJ, Fong JJ, Schwarz F, Mefford HC, Peterson GJ, Wells RD, Musvosvi M, Shey M, Hanekom WA, Hatherill M, Scriba TJ, Thuong NTT, Mai NTH, Caws M, ... ... Varki A, et al. The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes. Tuberculosis (Edinburgh, Scotland). 104: 38-45. PMID 28454648 DOI: 10.1016/J.Tube.2017.02.005  0.4
2017 Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State. Journal of Immunology (Baltimore, Md. : 1950). PMID 28148732 DOI: 10.4049/Jimmunol.1601471  0.64
2017 Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. The Embo Journal. PMID 28100677 DOI: 10.15252/Embj.201695581  0.4
2017 Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A. Physiological Exploration of the Long-term Evolutionary Selection Against Expression of N-glycolylneuraminic Acid in the Brain. The Journal of Biological Chemistry. PMID 28049733 DOI: 10.1074/Jbc.M116.768531  0.36
2016 Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. Studies on the detection, expression, glycosylation, dimerization and ligand binding properties of mouse Siglec-E. The Journal of Biological Chemistry. PMID 27920204 DOI: 10.1074/Jbc.M116.738351  0.4
2016 Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B. Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR. Cell Host & Microbe. PMID 27593514 DOI: 10.1016/J.Chom.2016.07.019  0.4
2016 Mahajan VS, Demissie E, Mattoo H, Viswanadham V, Varki A, Morris R, Pillai S. Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Cell Reports. PMID 27210752 DOI: 10.1016/J.Celrep.2016.04.080  0.44
2016 Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. PMID 27037304 DOI: 10.1093/Glycob/Cww042  0.4
2016 Springer SA, Schwarz F, Altheide TK, Varki NM, Varki A, Gagneux P. Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness. Proceedings of the National Academy of Sciences of the United States of America. PMID 26933219 DOI: 10.1073/Pnas.1601419113  0.4
2015 Gulati S, Schoenhofen IC, Whitfield DM, Cox AD, Li J, St Michael F, Vinogradov EV, Stupak J, Zheng B, Ohnishi M, Unemo M, Lewis LA, Taylor RE, Landig CS, Diaz S, ... ... Varki A, et al. Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics. Plos Pathogens. 11: e1005290. PMID 26630657 DOI: 10.1371/Journal.Ppat.1005290  0.44
2015 Schwarz F, Springer SA, Altheide TK, Varki NM, Gagneux P, Varki A. Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621708 DOI: 10.1073/Pnas.1517951112  0.44
2015 Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi CR, et al. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 25: 1323-4. PMID 26543186 DOI: 10.1093/Glycob/Cwv091  0.44
2015 Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. The Embo Journal. PMID 26459514 DOI: 10.15252/Embj.201591407  0.44
2015 Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, ... ... Varki A, et al. Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports. 11: 1966-78. PMID 26095364 DOI: 10.1016/J.Celrep.2015.05.044  0.4
2015 Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. Journal of Virology. 89: 6860-73. PMID 25903329 DOI: 10.1128/Jvi.00521-15  0.44
2015 Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, ... Varki A, et al. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 4. PMID 25846707 DOI: 10.7554/Elife.06184  0.44
2015 Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C. Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin. The Journal of Biological Chemistry. 290: 13202-14. PMID 25750127 DOI: 10.1074/Jbc.M115.638759  0.44
2015 Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Band K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A, Kornfeld SA. A red meat-derived glycan promotes inflammation and cancer progression Proceedings of the National Academy of Sciences of the United States of America. 112: 542-547. DOI: 10.1073/pnas.1417508112  0.44
2014 Läubli H, Alisson-Silva F, Stanczak MA, Siddiqui SS, Deng L, Verhagen A, Varki N, Varki A. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. The Journal of Biological Chemistry. 289: 33481-91. PMID 25320078 DOI: 10.1074/Jbc.M114.593129  0.4
2014 Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: 14211-6. PMID 25225409 DOI: 10.1073/Pnas.1409580111  0.44
2014 Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. Journal of Molecular Medicine (Berlin, Germany). 92: 951-9. PMID 24788876 DOI: 10.1007/S00109-014-1157-Y  0.44
2013 Soto PC, Karris MY, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. Journal of Molecular Medicine (Berlin, Germany). 91: 261-70. PMID 22945238 DOI: 10.1007/S00109-012-0951-7  0.44
2012 Chang YC, Uchiyama S, Varki A, Nizet V. Leukocyte inflammatory responses provoked by pneumococcal sialidase. Mbio. 3. PMID 22215570 DOI: 10.1128/Mbio.00220-11  0.44
2010 Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide DH. Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13. Respiratory Research. 11: 154. PMID 21040544 DOI: 10.1186/1465-9921-11-154  0.44
2010 Chandrasekharan K, Yoon JH, Xu Y, deVries S, Camboni M, Janssen PM, Varki A, Martin PT. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Science Translational Medicine. 2: 42ra54. PMID 20668298 DOI: 10.1126/Scitranslmed.3000692  0.4
2010 Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, ... ... Varki A, et al. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature. 466: 243-7. PMID 20555325 DOI: 10.1038/Nature09115  0.44
2009 Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi CR, Hart GW, Etzler ME. Symbol nomenclature for glycan representation. Proteomics. 9: 5398-9. PMID 19902428 DOI: 10.1002/Pmic.200900708  0.44
2009 Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. The Journal of Experimental Medicine. 206: 125-38. PMID 19103880 DOI: 10.1084/Jem.20081399  0.44
2008 Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology. 18: 747-9. PMID 18621991 DOI: 10.1093/Glycob/Cwn065  0.44
2007 Lanctot PM, Gage FH, Varki AP. The glycans of stem cells. Current Opinion in Chemical Biology. 11: 373-80. PMID 17681848 DOI: 10.1016/J.Cbpa.2007.05.032  0.44
2004 Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. The Journal of Clinical Investigation. 114: 1017-33. PMID 15489944 DOI: 10.1172/Jci23321  0.44
2001 Powell LD, Varki AP, Freeze HH. Release of saccharides from glycoconjugates Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. PMID 18432855 DOI: 10.1002/0471142735.Im0815S09  0.44
2001 Powell LD, Varki AP. Sialidases Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. PMID 18265140  0.44
1998 Varki A, Wills C, Perlmutter D, Woodruff D, Gage F, Moore J, Semendeferi K, Bernirschke K, Katzman R, Doolittle R, Bullock T. Great Ape Phenome Project? Science (New York, N.Y.). 282: 239-40. PMID 9841385 DOI: 10.1126/Science.282.5387.239D  0.44
1997 Varki AP, Kagnoff MF, Insel PA. Passing the baton at high speed: time to hand over to a new editorial board. The Journal of Clinical Investigation. 99: 553-4. PMID 9045851 DOI: 10.1172/Jci119192  0.44
1996 Ginsberg MH, Ruggeri ZM, Varki AP. Cell adhesion in vascular biology: series introductin The Journal of Clinical Investigation. 98: 1505. PMID 8833895 DOI: 10.1172/Jci118939  0.44
1996 Varki AP. The times they are still a'changing: keeping up with the times The Journal of Clinical Investigation. 97: 1. PMID 8550819 DOI: 10.1172/Jci118375  0.44
1992 Varki AP, Comenzo RL, Malachowski ME, Berkman EM. Changing blood types [5] New England Journal of Medicine. 327: 569. PMID 1635581 DOI: 10.1056/nejm199208203270817  0.44
1984 Cheresh DA, Reisfeld RA, Varki AP. O-Acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant Science. 225: 844-846. PMID 6206564 DOI: 10.1126/Science.6206564  0.44
1984 Cheresh DA, Varki AP, Varki NM, Stallcup WB, Levine J, Reisfeld RA. A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside Journal of Biological Chemistry. 259: 7453-7458. PMID 6203895  0.44
1983 Varki AP, Reitman ML, Tabas I, Kornfeld S. Studies of the synthesis, structure and function of the phosphorylated oligosaccharides of lysosomal enzymes Journal of Biosciences. 5: 101-104. DOI: 10.1007/Bf02702980  0.44
1982 Kornfeld S, Reitman ML, Varki A, Goldberg D, Gabel CA. Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes. Ciba Foundation Symposium. 138-56. PMID 6295719 DOI: 10.1002/9780470720745.ch8  0.44
1981 Varki AP, Reitman ML, Kornfeld S. Identification of a variant of mucolipidosis III (pseudo Hurler polydystrophy): A catalytically active N-acetylglucosaminylphosphotransferase that fails to phosphorylate lysosomal enzymes Proceedings of the National Academy of Sciences of the United States of America. 78: 7773-7777. PMID 6461005 DOI: 10.1073/Pnas.78.12.7773  0.44
1981 Reitman ML, Varki A, Kornfeld S. Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity. The Journal of Clinical Investigation. 67: 1574-9. PMID 6262380 DOI: 10.1172/Jci110189  0.44
1979 Varki AP, Puthuran P. Value of Second Lumbar Puncture in Confirming a Diagnosis of Aseptic Meningitis: A Prospective Study Archives of Neurology. 36: 581-582. PMID 475624 DOI: 10.1001/Archneur.1979.00500450075016  0.44
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