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Patrick E. Hanna - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Toxicology, Pharmacy, Biochemistry
Website:
https://www.pharmacy.umn.edu/bio/pharmacy-faculty-a-z/patrick-hanna
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hanna PE, Anders MW. The mercapturic acid pathway. Critical Reviews in Toxicology. 1-111. PMID 31944156 DOI: 10.1080/10408444.2019.1692191  0.347
2009 Zhou X, Zhang N, Liu L, Walters KJ, Hanna PE, Wagner CR. Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190. The Febs Journal. 276: 6928-41. PMID 19860825 DOI: 10.1111/J.1742-4658.2009.07389.X  0.362
2009 Liu L, Wagner CR, Hanna PE. Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines. Chemical Research in Toxicology. 22: 1962-74. PMID 19842618 DOI: 10.1021/Tx9002676  0.48
2008 Liu L, Wagner CR, Hanna PE. Human arylamine N-acetyltransferase 1: in vitro and intracellular inactivation by nitrosoarene metabolites of toxic and carcinogenic arylamines. Chemical Research in Toxicology. 21: 2005-16. PMID 18759501 DOI: 10.1021/Tx800215H  0.396
2007 Liu L, Von Vett A, Zhang N, Walters KJ, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2. Chemical Research in Toxicology. 20: 1300-8. PMID 17672512 DOI: 10.1021/Tx7001614  0.453
2007 Minchin RF, Hanna PE, Dupret JM, Wagner CR, Rodrigues-Lima F, Butcher NJ. Arylamine N-acetyltransferase I. The International Journal of Biochemistry & Cell Biology. 39: 1999-2005. PMID 17392017 DOI: 10.1016/J.Biocel.2006.12.006  0.339
2006 Zhang N, Liu L, Liu F, Wagner CR, Hanna PE, Walters KJ. NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity. Journal of Molecular Biology. 363: 188-200. PMID 16959263 DOI: 10.1016/J.Jmb.2006.08.026  0.385
2006 Liu F, Zhang N, Zhou X, Hanna PE, Wagner CR, Koepp DM, Walters KJ. Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation. Journal of Molecular Biology. 361: 482-92. PMID 16857211 DOI: 10.1016/J.Jmb.2006.06.029  0.312
2005 Wang H, Liu L, Hanna PE, Wagner CR. Catalytic mechanism of hamster arylamine N-acetyltransferase 2. Biochemistry. 44: 11295-306. PMID 16101314 DOI: 10.1021/Bi047564Q  0.322
2005 Wang H, Vath GM, Kawamura A, Bates CA, Sim E, Hanna PE, Wagner CR. Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. The Protein Journal. 24: 65-77. PMID 16003948 DOI: 10.1007/S10930-004-1513-9  0.355
2005 Wang H, Wagner CR, Hanna PE. Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes. Chemical Research in Toxicology. 18: 183-97. PMID 15720122 DOI: 10.1021/Tx049801W  0.497
2005 Kawamura A, Graham J, Mushtaq A, Tsiftsoglou SA, Vath GM, Hanna PE, Wagner CR, Sim E. Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochemical Pharmacology. 69: 347-59. PMID 15627487 DOI: 10.1016/J.Bcp.2004.09.014  0.364
2005 Wang H, Liu L, Hanna PE, Wagner CR. Erratum: Catalytic mechanism of hamster arylamine N-acetyltransferase 2 (Biochemistry (August 23, 2005) 44, 3 (11295-11306)) Biochemistry. 44. DOI: 10.1021/Bi0580310  0.421
2004 Wang H, Vath GM, Gleason KJ, Hanna PE, Wagner CR. Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies. Biochemistry. 43: 8234-46. PMID 15209520 DOI: 10.1021/Bi0497244  0.358
2004 Wang H, Guo Z, Vath GM, Wagner CR, Hanna PE. Chemical modification of hamster arylamine N-acetyltransferase 2 with isozyme-selective and nonselective N-arylbromoacetamido reagents. The Protein Journal. 23: 153-66. PMID 15106881 DOI: 10.1023/B:Jopc.0000020082.14480.E2  0.608
2004 Guo Z, Wagner CR, Hanna PE. Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene. Chemical Research in Toxicology. 17: 275-86. PMID 15025497 DOI: 10.1021/Tx030045O  0.612
2003 Guo Z, Vath GM, Wagner CR, Hanna PE. Arylamine N-acetyltransferases: covalent modification and inactivation of hamster NAT1 by bromoacetamido derivatives of aniline and 2-aminofluorene. Journal of Protein Chemistry. 22: 631-42. PMID 14714730 DOI: 10.1023/B:Jopc.0000008728.17159.Dd  0.487
1998 Sticha KR, Bergstrom CP, Wagner CR, Hanna PE. Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases: bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene. Biochemical Pharmacology. 56: 47-59. PMID 9698088 DOI: 10.1016/S0006-2952(98)00101-4  0.442
1997 Sticha KR, Sieg CA, Bergstrom CP, Hanna PE, Wagner CR. Overexpression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein. Protein Expression and Purification. 10: 141-53. PMID 9179301 DOI: 10.1006/Prep.1997.0734  0.324
1997 Ojala WH, Iyer RA, Hanna PE, Gleason WB. Heterocyclic N-acetoxyarylamines, models for the putative ultimate carcinogens of aromatic amines: 2-acetoxyamino-5-phenylpyridine and 2-acetoxyaminopyridine Acta Crystallographica. Section C, Crystal Structure Communications. 53. PMID 9176990  0.304
1995 Bergstrom CP, Wagner CR, Ann DK, Hanna PE. Hamster monomorphic arylamine N-acetyltransferase: expression in Escherichia coli and purification. Protein Expression and Purification. 6: 45-55. PMID 7756838 DOI: 10.1006/Prep.1995.1007  0.376
1995 Iyer RA, Hanna PE. N-(carbobenzyloxy)isatin: A slow binding α-keto lactam inhibitor of α-chymotrypsin Bioorganic and Medicinal Chemistry Letters. 5: 89-92. DOI: 10.1016/0960-894X(94)00464-Q  0.419
1994 Hanna PE. N-Acetyltransferases, O-Acetyltransferases, and N, O-Acetyltransferases: Enzymology and Bioactivation Advances in Pharmacology. 27: 401-430. PMID 8068562 DOI: 10.1016/S1054-3589(08)61041-8  0.439
1994 Wick MJ, Hanna PE. Inactivation of hamster monomorphic N-acetyltransferase by vinyl fluorenyl ketone Biochemical Pharmacology. 48: 1835-1838. PMID 7980653 DOI: 10.1016/0006-2952(94)90470-7  0.423
1994 Boteju LW, Hanna PE. Arylamine-nucleoside adduct formation: Evidence for arylnitrene involvement in the reactions of an N-acetoxyarylamine Chemical Research in Toxicology. 7: 684-689. PMID 7841348 DOI: 10.1021/Tx00041A014  0.462
1993 Boteju LW, Hanna PE. Bioactivation of N-hydroxy-2-acetylaminofluorenes by n,o-acyltransferase: Substituent effects on covalent binding to DNA Carcinogenesis. 14: 1651-1657. PMID 8353850 DOI: 10.1093/Carcin/14.8.1651  0.457
1992 Hyae Gyeong C, Hanna PE. Effect of group-selective modification reagents on arylamine N-acetyltransferase activities Biochemical Pharmacology. 43: 2255-2268. PMID 1599511 DOI: 10.1016/0006-2952(92)90185-L  0.351
1992 Babson JR, Gavitt NE, Boteju LW, Hanna PE. Comparative toxicity and mutagenecity of N-hydroxy-2-acetylaminofluorene and 7-acetyl-N-hydroxy-2-acetylaminofluorene in human lymphoblasts Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 269: 73-78. PMID 1381473 DOI: 10.1016/0027-5107(92)90162-U  0.486
1990 Wick MJ, Yeh HM, Hanna PE. An isozyme-selective affinity label for rat hepatic acetyltransferases Biochemical Pharmacology. 40: 1389-1398. PMID 2403393 DOI: 10.1016/0006-2952(90)90408-D  0.478
1990 Wick MJ, Hanna PE. Bioactivation of N-arylhydroxamic acids by rat hepatic N-acetyltransferase. Detection of multiple enzyme forms by mechanism-based inactivation Biochemical Pharmacology. 39: 991-1003. PMID 2322300 DOI: 10.1016/0006-2952(90)90277-R  0.482
1990 Hanna PE, El-Ghandour AM, McCormack ME. Analogues of n-hydroxy-4-acetylaminobiphenyl as substrates and inactivators of hamster hepatic acetyltransferases Xenobiotica. 20: 739-751. PMID 2238707 DOI: 10.3109/00498259009046889  0.39
1988 Wick MJ, Bin Jantan I, Hanna PE. Irreversible inhibition of rat hepatic transacetylase activity by N-Arylhydroxamic acids Biochemical Pharmacology. 37: 1225-1231. PMID 3355596 DOI: 10.1016/0006-2952(88)90775-7  0.483
1988 Smith TJ, Hanna PE. Hepatic N-acetyltransferases: Selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid Biochemical Pharmacology. 37: 427-434. PMID 3257389 DOI: 10.1016/0006-2952(88)90210-9  0.483
1986 Smith TJ, Hanna PE. N-acetyltransferase multiplicity and the bioactivation of n-arylhydroxamic acids by hamster hepatic and intestinal enzymes Carcinogenesis. 7: 697-702. PMID 3486051 DOI: 10.1093/Carcin/7.5.697  0.483
1985 Elfarra AA, Hanna PE. Substituent effects on the bioactivation of 2-(N-hydroxyacetamido)fluorenes by N-arylhydroxamic acid N,O-acyltransferase Journal of Medicinal Chemistry. 28: 1453-1460. PMID 4045921 DOI: 10.1002/Chin.198605330  0.476
1985 Marhevka VC, Ebner NA, Sehon RD, Hanna PE. Mechanism-based inactivation of N-arylhydroxamic acid N,O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes Journal of Medicinal Chemistry. 28: 18-24. PMID 3965709 DOI: 10.1002/Chin.198521151  0.499
1983 Banks RB, Smith TJ, Hanna PE. N-arylhydroxamic acid N,O-acyltransferase. Positional requirements for the substrate hydroxyl group Journal of Medicinal Chemistry. 26: 1780-1784. PMID 6644748 DOI: 10.1002/Chin.198419346  0.489
1982 Elfarra AA, Yeh HM, Hanna PE. Synthesis and evaluation of N-(phenylalkyl)acetohydroxamic acids as potential substrates for N-arylhydroxamic acid N,O-acyltransferase Journal of Medicinal Chemistry. 25: 1189-1192. PMID 7143355 DOI: 10.1002/Chin.198310177  0.476
1982 Hanna PE, Banks RB, Marhevka VC. Suicide inactivation of hamster hepatic arylhydroxamic acid N,O-acyltransferase. A selective probe of N-acetyltransferase multiplicity Molecular Pharmacology. 21: 159-165. PMID 7132954  0.381
1982 Yeh HM, Hanna PE. Arylhydroxamic acid bioactivation via acyl group transfer. Structural requirements for transacylating and electrophile-generating activity of N-(2-fluorenyl)hydroxamic acids and related compounds Journal of Medicinal Chemistry. 25: 842-846. PMID 7108899 DOI: 10.1002/Chin.198249194  0.484
1982 Shirota FN, Hanna PE. Effect of 4′-halogen substitution on the mutagenicity of trans-4-acetamidostilbene and trans-4-(n-hydroxyacetamido)stilbene in the Salmonella typhimurium test system Journal of Medicinal Chemistry. 25: 593-595. PMID 7045369 DOI: 10.1002/Chin.198241355  0.328
1982 Mangold BLK, Hanna PE. Arylhydroxamic acid N,O-acyltransferase substrates. Acetyl transfer and electrophile generating activity of N-hydroxy-N-(4-alkyl-, 4-alkenyl-, and 4-cyclohexylphenyl)acetamides Journal of Medicinal Chemistry. 25: 630-638. PMID 6765899 DOI: 10.1002/Chin.198246141  0.504
1980 Anders MW, Harris Ratnayake J, Hanna PE, Fuchs JA. Involvement of thioredoxin in sulfoxide reduction by mammalian tissues Biochemical and Biophysical Research Communications. 97: 846-851. PMID 7470152 DOI: 10.1016/0006-291X(80)91454-0  0.314
1980 Hanna PE, Gammans RE, Sehon RD, Lee MK. Metabolic N-hydroxylation. Use of substituent variation to modulate the in vitro bioactivation of 4-acetamidostilbenes Journal of Medicinal Chemistry. 23: 1038-1044. PMID 7411547 DOI: 10.1002/Chin.198109208  0.413
1980 Mangold BLK, Hanna PE. N-acetyltransferase (NAT) catalyzed bioactivation of para-substituted N-phenylacetohydroxamic acids Pharmacologist. 22: 309.  0.38
1979 Banks RB, Hanna PE. Arylhydroxamic acid N,O-acyltransferase. Apparent suicide inactivation by carcinogenic N-arylhydroxamic acids Biochemical and Biophysical Research Communications. 91: 1423-1429. PMID 526312 DOI: 10.1016/0006-291X(79)91225-7  0.459
1976 Ahmed AE, Hanna PE, Grund VR. Conformationally restricted analogs of histamine H1 receptor antagonists: trans-and cis-1-Benzyl-3-dimethylamino-6-phenylpiperidine Journal of Medicinal Chemistry. 19: 117-122. PMID 1535 DOI: 10.1002/Chin.197617235  0.309
1974 Hanna PE, Borchardt RT. Histamine N-methyltransferase. Inhibition and potentiation by trans- and cis-1,5-diphenyl-3-dimethylaminopyrrolidine Journal of Medicinal Chemistry. 17: 741-743. PMID 4830549 DOI: 10.1021/Jm00250A027  0.372
1973 Hanna PE. 3-Amino-5-phenyl-1-(2-pyridyl)pyrrolidines. Synthesis and stereochemistry Journal of Heterocyclic Chemistry. 10: 747-753. DOI: 10.1002/Jhet.5570100512  0.33
1970 Mertes MP, Hanna PE, Ramsey AA. Synthesis of gamma-dimethylamino-alpha-phenylcycloalkyl propionates as potential analgetics. Journal of Medicinal Chemistry. 13: 125-8. PMID 5460892 DOI: 10.1021/Jm00295A031  0.55
1970 Mertes MP, Ramsey AA, Hanna PE, Miller DD. Synthesis of gamma-dimethylaminomethyl-alpha-phenylcycloalkyl propionates as potential analgetics. Journal of Medicinal Chemistry. 13: 789-94. PMID 5458360 DOI: 10.1021/Jm00299A001  0.549
1970 MERTES MP, HANNA PE, RAMSEY AA. ChemInform Abstract: SYNTH. VON GAMMA-DIMETHYLAMINO-ALPHA-PHENYLCYCLOALKYLPROPIONATEN ALS POTENTIELLE ANALGETICA Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197020219  0.535
1970 Mertes MP, Ramsey AA, Hanna PE, Miller DD. Synthesis of γ-dimethylaminomethyl-α-phenylcycloalkyl propionates as potential analgetics Journal of Medicinal Chemistry. 13: 789-794.  0.479
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