Adrian C. Michael - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Analytical Chemistry, Neuroscience Biology, Biochemistry

87 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lotfi Marchoubeh M, Cobb SJ, Abrego Tello M, Hu M, Jaquins-Gerstl A, Robbins EM, Macpherson JV, Michael AC, Fritsch I. Miniaturized probe on polymer SU-8 with array of individually addressable microelectrodes for electrochemical analysis in neural and other biological tissues. Analytical and Bioanalytical Chemistry. PMID 33961102 DOI: 10.1007/s00216-021-03327-2  0.76
2021 Jaquins-Gerstl A, Nesbitt KM, Michael AC. In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum. Analytical and Bioanalytical Chemistry. PMID 33843017 DOI: 10.1007/s00216-021-03300-z  0.76
2020 Jaquins-Gerstl A, Michael AC. Dexamethasone-Enhanced Microdialysis and Penetration Injury. Frontiers in Bioengineering and Biotechnology. 8: 602266. PMID 33364231 DOI: 10.3389/fbioe.2020.602266  0.76
2020 Castagnola E, Robbins EM, Woeppel KM, McGuier M, Golabchi A, Taylor IM, Michael AC, Cui XT. Real-Time Fast Scan Cyclic Voltammetry Detection and Quantification of Exogenously Administered Melatonin in Mice Brain. Frontiers in Bioengineering and Biotechnology. 8: 602216. PMID 33330433 DOI: 10.3389/fbioe.2020.602216  0.8
2020 Walters SH, Shu Z, Michael AC, Levitan ES. Regional Variation in Striatal Dopamine Spillover and Release Plasticity. Acs Chemical Neuroscience. 11: 888-899. PMID 32073248 DOI: 10.1021/Acschemneuro.9B00577  0.8
2019 Robbins EM, Jaquins-Gerstl A, Fine DF, Leong CL, Dixon CE, Wagner AK, Boutelle MG, Michael AC. Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex. Acs Chemical Neuroscience. PMID 31246409 DOI: 10.1021/Acschemneuro.9B00145  0.76
2017 Varner EL, Leong CL, Jaquins-Gerstl A, Nesbitt KM, Boutelle MG, Michael AC. Enhancing Continuous Online Microdialysis using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization. Acs Chemical Neuroscience. PMID 28482157 DOI: 10.1021/Acschemneuro.7B00148  0.76
2017 Ngo KT, Varner EL, Michael AC, Weber SG. Monitoring Dopamine Responses to Potassium Ion and Nomifensine by in vivo Microdialysis with Online Liquid Chromatography at One-Minute Resolution. Acs Chemical Neuroscience. PMID 28094974 DOI: 10.1021/Acschemneuro.6B00383  0.72
2016 Varner EL, Jaquins-Gerstl A, Michael AC. Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track. Acs Chemical Neuroscience. PMID 27003503 DOI: 10.1021/Acschemneuro.5B00331  1
2016 Kozai TD, Jaquins-Gerstl AS, Vazquez AL, Michael AC, Cui XT. Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo. Biomaterials. 87: 157-169. PMID 26923363 DOI: 10.1016/J.Biomaterials.2016.02.013  0.6
2016 Walters SH, Robbins EM, Michael AC. Kinetic Diversity of Striatal Dopamine: Evidence from a Novel Protocol for Voltammetry. Acs Chemical Neuroscience. PMID 26886408 DOI: 10.1021/Acschemneuro.6B00020  0.6
2015 Michael AC. Comment on "Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transporter Kinetics in Vivo". Acs Chemical Neuroscience. PMID 26120781 DOI: 10.1021/cn5002232  1
2015 Walters SH, Robbins EM, Michael AC. Modeling the Kinetic Diversity of Dopamine in the Dorsal Striatum. Acs Chemical Neuroscience. PMID 26083009 DOI: 10.1021/Acschemneuro.5B00128  1
2015 Gu H, Varner EL, Groskreutz SR, Michael AC, Weber SG. In Vivo Monitoring of Dopamine by Microdialysis with 1 min Temporal Resolution Using Online Capillary Liquid Chromatography with Electrochemical Detection. Analytical Chemistry. 87: 6088-94. PMID 25970591 DOI: 10.1021/Acs.Analchem.5B00633  1
2015 Jaquins-Gerstl A, Michael AC. A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue. The Analyst. 140: 3696-708. PMID 25876757 DOI: 10.1039/C4An02065K  1
2015 Taylor IM, Nesbitt KM, Walters SH, Varner EL, Shu Z, Bartlow KM, Jaquins-Gerstl AS, Michael AC. Kinetic diversity of dopamine transmission in the dorsal striatum. Journal of Neurochemistry. 133: 522-31. PMID 25683259 DOI: 10.1111/Jnc.13059  1
2015 Kozai TD, Jaquins-Gerstl AS, Vazquez AL, Michael AC, Cui XT. Brain tissue responses to neural implants impact signal sensitivity and intervention strategies. Acs Chemical Neuroscience. 6: 48-67. PMID 25546652 DOI: 10.1021/Cn500256E  1
2015 Nesbitt KM, Varner EL, Jaquins-Gerstl A, Michael AC. Microdialysis in the rat striatum: effects of 24 h dexamethasone retrodialysis on evoked dopamine release and penetration injury. Acs Chemical Neuroscience. 6: 163-73. PMID 25491242 DOI: 10.1021/Cn500257X  1
2015 Groskreutz SR, Horner AR, Varner EL, Yin B, Michael AC, Weber SG. A selective report on topics at Pittcon 2015 Trac - Trends in Analytical Chemistry. 68: 133-139. DOI: 10.1016/J.Trac.2015.04.005  1
2014 Walters SH, Taylor IM, Shu Z, Michael AC. A novel restricted diffusion model of evoked dopamine. Acs Chemical Neuroscience. 5: 776-83. PMID 24983330 DOI: 10.1021/Cn5000666  1
2014 Shu Z, Taylor IM, Walters SH, Michael AC. Region- and domain-dependent action of nomifensine. The European Journal of Neuroscience. 40: 2320-8. PMID 24766210 DOI: 10.1111/Ejn.12604  1
2013 Zhang J, Jaquins-Gerstl A, Nesbitt KM, Rutan SC, Michael AC, Weber SG. In vivo monitoring of serotonin in the striatum of freely moving rats with one minute temporal resolution by online microdialysis-capillary high-performance liquid chromatography at elevated temperature and pressure. Analytical Chemistry. 85: 9889-97. PMID 24020786 DOI: 10.1021/Ac4023605  1
2013 Shu Z, Taylor IM, Michael AC. The dopamine patchwork of the rat nucleus accumbens core. The European Journal of Neuroscience. 38: 3221-9. PMID 23937532 DOI: 10.1111/Ejn.12319  1
2013 Nesbitt KM, Jaquins-Gerstl A, Skoda EM, Wipf P, Michael AC. Pharmacological mitigation of tissue damage during brain microdialysis. Analytical Chemistry. 85: 8173-9. PMID 23927692 DOI: 10.1021/Ac401201X  1
2013 Taylor IM, Ilitchev AI, Michael AC. Restricted diffusion of dopamine in the rat dorsal striatum. Acs Chemical Neuroscience. 4: 870-8. PMID 23600442 DOI: 10.1021/Cn400078N  1
2013 Jaquins-Gerstl A, Michael AC. The advantage of microelectrode technologies for measurement in delicate biological environments such as brain tissue Neuromethods. 80: 55-68. DOI: 10.1007/978-1-62703-370-1-3  1
2012 Zhang J, Liu Y, Jaquins-Gerstl A, Shu Z, Michael AC, Weber SG. Optimization for speed and sensitivity in capillary high performance liquid chromatography. The importance of column diameter in online monitoring of serotonin by microdialysis. Journal of Chromatography. A. 1251: 54-62. PMID 22771067 DOI: 10.1016/J.Chroma.2012.06.002  1
2012 Moquin KF, Jaquins-Gerstl A, Michael AC. A method for the intracranial delivery of reagents to voltammetric recording sites. Journal of Neuroscience Methods. 208: 101-7. PMID 22580054 DOI: 10.1016/J.Jneumeth.2012.05.001  1
2012 Mitch Taylor I, Jaquins-Gerstl A, Sesack SR, Michael AC. Domain-dependent effects of DAT inhibition in the rat dorsal striatum. Journal of Neurochemistry. 122: 283-94. PMID 22548305 DOI: 10.1111/J.1471-4159.2012.07774.X  1
2012 Wang Y, Michael AC. Microdialysis probes alter presynaptic regulation of dopamine terminals in rat striatum. Journal of Neuroscience Methods. 208: 34-9. PMID 22546476 DOI: 10.1016/J.Jneumeth.2012.04.009  1
2011 Jaquins-Gerstl A, Shu Z, Zhang J, Liu Y, Weber SG, Michael AC. Effect of dexamethasone on gliosis, ischemia, and dopamine extraction during microdialysis sampling in brain tissue Analytical Chemistry. 83: 7662-7667. PMID 21859125 DOI: 10.1021/Ac200782H  1
2011 Moquin KF, Michael AC. An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux. Journal of Neurochemistry. 117: 133-42. PMID 21244425 DOI: 10.1111/J.1471-4159.2011.07183.X  1
2010 Wang Y, Moquin KF, Michael AC. Evidence for coupling between steady-state and dynamic extracellular dopamine concentrations in the rat striatum. Journal of Neurochemistry. 114: 150-9. PMID 20403079 DOI: 10.1111/J.1471-4159.2010.06740.X  1
2010 Smith AD, Michael AC, Lopresti BJ, Narendran R, Zigmond MJ. Monoamines: Release studies Encyclopedia of Neuroscience. 953-960. DOI: 10.1016/B978-008045046-9.01152-9  1
2009 Moquin KF, Michael AC. Tonic autoinhibition contributes to the heterogeneity of evoked dopamine release in the rat striatum. Journal of Neurochemistry. 110: 1491-501. PMID 19627437 DOI: 10.1111/J.1471-4159.2009.06254.X  1
2009 Jaquins-Gerstl A, Michael AC. Comparison of the brain penetration injury associated with microdialysis and voltammetry. Journal of Neuroscience Methods. 183: 127-35. PMID 19559724 DOI: 10.1016/J.Jneumeth.2009.06.023  1
2009 Wagner AK, Sokoloski JE, Chen X, Harun R, Clossin DP, Khan AS, Andes-Koback M, Michael AC, Dixon CE. Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission. Journal of Neurochemistry. 110: 801-10. PMID 19457094 DOI: 10.1111/J.1471-4159.2009.06155.X  1
2009 Wagner AK, Drewencki LL, Chen X, Santos FR, Khan AS, Harun R, Torres GE, Michael AC, Dixon CE. Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury. Journal of Neurochemistry. 108: 986-97. PMID 19077052 DOI: 10.1111/J.1471-4159.2008.05840.X  1
2008 Mitala CM, Wang Y, Borland LM, Jung M, Shand S, Watkins S, Weber SG, Michael AC. Impact of microdialysis probes on vasculature and dopamine in the rat striatum: A combined fluorescence and voltammetric study Journal of Neuroscience Methods. 174: 177-185. PMID 18674561 DOI: 10.1016/J.Jneumeth.2008.06.034  1
2007 Michael AC. The 16th James L. Waters Annual Symposium: Electrochemistry Journal of Chemical Education. 84: 643. DOI: 10.1021/Ed084P643  1
2006 Jung MC, Munro N, Shi G, Michael AC, Weber SG. Use of tris(2,2'-bipyridine)osmium as a photoluminescence-following electron-transfer reagent for postcolumn detection in capillary high-performance liquid chromatography. Analytical Chemistry. 78: 1761-8. PMID 16536409 DOI: 10.1021/Ac051182O  1
2006 Jung MC, Shi G, Borland L, Michael AC, Weber SG. Simultaneous determination of biogenic monoamines in rat brain dialysates using capillary high-performance liquid chromatography with photoluminescence following electron transfer. Analytical Chemistry. 78: 1755-60. PMID 16536408 DOI: 10.1021/Ac051183G  1
2006 Michael AC. Chapter 1.6 Quantitative aspects of brain microdialysis: insights from voltammetric measurements of dopamine next to microdialysis probes Handbook of Behavioral Neuroscience. 16: 93-107. DOI: 10.1016/S1569-7339(06)16006-3  1
2006 Mitala JJ, Michael AC. Improving the performance of electrochemical microsensors based on enzymes entrapped in a redox hydrogel Analytica Chimica Acta. 556: 326-332. DOI: 10.1016/J.Aca.2005.09.053  1
2005 Wagner AK, Sokoloski JE, Ren D, Chen X, Khan AS, Zafonte RD, Michael AC, Dixon CE. Controlled cortical impact injury affects dopaminergic transmission in the rat striatum. Journal of Neurochemistry. 95: 457-65. PMID 16190869 DOI: 10.1111/J.1471-4159.2005.03382.X  1
2005 Michael AC, Borland LM, Mitala JJ, Willoughby BM, Motzko CM. Theory for the impact of basal turnover on dopamine clearance kinetics in the rat striatum after medial forebrain bundle stimulation and pressure ejection. Journal of Neurochemistry. 94: 1202-11. PMID 15992374 DOI: 10.1111/J.1471-4159.2005.03265.X  1
2005 Borland LM, Shi G, Yang H, Michael AC. Voltammetric study of extracellular dopamine near microdialysis probes acutely implanted in the striatum of the anesthetized rat. Journal of Neuroscience Methods. 146: 149-58. PMID 15975664 DOI: 10.1016/J.Jneumeth.2005.02.002  1
2004 Borland LM, Michael AC. Voltammetric study of the control of striatal dopamine release by glutamate. Journal of Neurochemistry. 91: 220-9. PMID 15379902 DOI: 10.1111/J.1471-4159.2004.02708.X  1
2004 Peters JL, Miner LH, Michael AC, Sesack SR. Ultrastructure at carbon fiber microelectrode implantation sites after acute voltammetric measurements in the striatum of anesthetized rats. Journal of Neuroscience Methods. 137: 9-23. PMID 15196823 DOI: 10.1016/J.Jneumeth.2004.02.006  1
2003 Kulagina NV, Michael AC. Monitoring hydrogen peroxide in the extracellular space of the brain with amperometric microsensors. Analytical Chemistry. 75: 4875-81. PMID 14674466 DOI: 10.1021/Ac034573G  1
2003 Khan AS, Michael AC. Invasive consequences of using micro-electrodes and microdialysis probes in the brain Trac - Trends in Analytical Chemistry. 22: 503-508. DOI: 10.1016/S0165-9936(03)00908-7  1
2002 Dressman SF, Peters JL, Michael AC. Carbon fiber microelectrodes with multiple sensing elements for in vivo voltammetry. Journal of Neuroscience Methods. 119: 75-81. PMID 12234638 DOI: 10.1016/S0165-0270(02)00180-2  1
2001 Kulagina NV, Zigmond MJ, Michael AC. Glutamate regulates the spontaneous and evoked release of dopamine in the rat striatum. Neuroscience. 102: 121-8. PMID 11226675 DOI: 10.1016/S0306-4522(00)00480-2  1
2001 Cui J, Kulagina NV, Michael AC. Pharmacological evidence for the selectivity of in vivo signals obtained with enzyme-based electrochemical sensors. Journal of Neuroscience Methods. 104: 183-9. PMID 11164244 DOI: 10.1016/S0165-0270(00)00343-5  1
2000 Yang H, Peters JL, Allen C, Chern SS, Coalson RD, Michael AC. A theoretical description of microdialysis with mass transport coupled to chemical events. Analytical Chemistry. 72: 2042-9. PMID 10815963 DOI: 10.1021/Ac991186R  1
2000 Peters JL, Michael AC. Changes in the kinetics of dopamine release and uptake have differential effects on the spatial distribution of extracellular dopamine concentration in rat striatum. Journal of Neurochemistry. 74: 1563-73. PMID 10737613 DOI: 10.1046/J.1471-4159.2000.0741563.X  1
2000 Wu Y, Pearl SM, Zigmond MJ, Michael AC. Inhibitory glutamatergic regulation of evoked dopamine release in striatum. Neuroscience. 96: 65-72. PMID 10683411 DOI: 10.1016/S0306-4522(99)00539-4  1
2000 Peters JL, Yang H, Michael AC. Quantitative aspects of brain microdialysis Analytica Chimica Acta. 412: 1-12. DOI: 10.1016/S0003-2670(99)00839-9  1
1999 Kulagina NV, Shankar L, Michael AC. Monitoring glutamate and ascorbate in the extracellular space of brain tissue with electrochemical microsensors. Analytical Chemistry. 71: 5093-100. PMID 10575963 DOI: 10.1021/Ac990636C  1
1999 Qian J, Wu Y, Yang H, Michael AC. An integrated decoupler for capillary electrophoresis with electrochemical detection: Application to analysis of brain microdialysate Analytical Chemistry. 71: 4486-4492. PMID 10546530 DOI: 10.1021/Ac990338F  1
1998 Yang H, Peters JL, Michael AC. Coupled effects of mass transfer and uptake kinetics on in vivo microdialysis of dopamine. Journal of Neurochemistry. 71: 684-92. PMID 9681459 DOI: 10.1046/J.1471-4159.1998.71020684.X  1
1998 Peters JL, Michael AC. Modeling voltammetry and microdialysis of striatal extracellular dopamine: the impact of dopamine uptake on extraction and recovery ratios. Journal of Neurochemistry. 70: 594-603. PMID 9453553 DOI: 10.1046/J.1471-4159.1998.70020594.X  1
1998 Lu Y, Peters JL, Michael AC. Direct comparison of the response of voltammetry and microdialysis to electrically evoked release of striatal dopamine. Journal of Neurochemistry. 70: 584-93. PMID 9453552 DOI: 10.1046/J.1471-4159.1998.70020584.X  1
1996 Garguilo MG, Michael AC. Amperometric microsensors for monitoring choline in the extracellular fluid of brain Journal of Neuroscience Methods. 70: 73-82. PMID 8982984 DOI: 10.1016/S0165-0270(96)00105-7  1
1996 Dressman SF, Simeone AM, Michael AC. Supercritical Fluid Chromatography with Electrochemical Detection of Phenols and Polyaromatic Hydrocarbons Analytical Chemistry. 68: 3121-3127. DOI: 10.1021/Ac951188L  1
1995 Garguilo MG, Michael AC. Enzyme-modified electrodes for peroxide, choline, and acetylcholine Trends in Analytical Chemistry. 14: 164-169. DOI: 10.1016/0165-9936(95)98314-X  1
1995 Garguilo MG, Michael AC. Optimization of amperometric microsensors for monitoring choline in the extracellular fluid of brain tissue Analytica Chimica Acta. 307: 291-299. DOI: 10.1016/0003-2670(94)00558-4  1
1995 Dressman SF, Michael AC. On-Line Electrochemical Detection for Supercritical Fluid Chromatography Analytical Chemistry. 67: 1339-1345.  1
1994 Gargullo MG, Michael AC. Quantitation of choline in the extracellular fluid of brain tissue with amperometric microsensors Analytical Chemistry. 66: 2621-2629. PMID 7943733 DOI: 10.1021/Ac00089A006  1
1994 Sullenberger EF, Dressman SF, Michael AC. Voltammetry of p-benzoquinone and anthracene at poly(ethylene oxide)-coated microelectrodes in CO2-based fluids Journal of Physical Chemistry. 98: 5347-5354. DOI: 10.1021/J100071A027  1
1993 Garguilo MG, Huynh N, Proctor A, Michael AC. Amperometric sensors for peroxide, choline, and acetylcholine based on electron transfer between horseradish peroxidase and a redox polymer Analytical Chemistry. 65: 523-528. PMID 8452244 DOI: 10.1021/Ac00053A007  1
1993 Young SD, Michael AC. Voltammetry of extracellular dopamine in rat striatum during ICSS-like electrical stimulation of the medial forebrain bundle Brain Research. 600: 305-307. PMID 8435753 DOI: 10.1016/0006-8993(93)91387-8  1
1993 Garguilo MG, Michael AC. An enzyme-modified microelectrode that detects choline injected locally into brain tissue Journal of the American Chemical Society. 115: 12218-12219. DOI: 10.1021/Ja00078A092  1
1993 Sullenberger EF, Michael AC. Effects of carbon dioxide fluids on perfluorinated ionomer films: A study by voltammetry, DSC, and SEM Analytical Chemistry. 65: 3417-3423. DOI: 10.1021/Ac00071A014  1
1993 Sullenberger EF, Michael AC. Voltammetry with poly(ethylene oxide)-coated microelectrodes in carbon dioxide Analytical Chemistry. 65: 2304-2310. DOI: 10.1021/Ac00065A023  1
1993 Dressman SF, Garguilo MG, Sullenberger EF, Michael AC. Characterization of the electroenzymatic reduction of H2O2 in carbon dioxide by voltammetry with a chemically-modified microelectrode Journal of the American Chemical Society. 115: 7541-7542.  1
1991 Pishko MV, Michael AC, Heller A. Amperometric glucose microelectrodes prepared through immobilization of glucose oxidase in redox hydrogels Analytical Chemistry. 63: 2268-2272. PMID 1759711 DOI: 10.1021/Ac00020A014  1
1991 Fosset B, Amatore CA, Bartelt JE, Michael AC, Wightman RM. Use of conformal maps to model the voltammetric response of collector-generator double-band electrodes Analytical Chemistry. 63: 306-314. DOI: 10.1021/Ac00004A003  1
1989 Michael AC, Wightman RM. Microelectrodes coated with ionically conducting polymer membranes for voltammetric detection in flowing supercritical carbon dioxide [1] Analytical Chemistry. 61: 270-272. DOI: 10.1021/Ac00178A016  1
1989 Michael AC, Wightman RM, Amatore CA. Microdisk electrodes. Part I. Digital simulation with a conformal map Journal of Electroanalytical Chemistry. 267: 33-45. DOI: 10.1016/0022-0728(89)80235-9  1
1989 Wipf DO, Michael AC, Wightman RM. Microdisk electrodes. Part II. Fast-scan cyclic voltammetry with very small electrodes Journal of Electroanalytical Chemistry. 269: 15-25. DOI: 10.1016/0022-0728(89)80100-7  1
1988 Justice JB, Nicolaysen LC, Michael AC. Modeling the dopaminergic nerve terminal. Journal of Neuroscience Methods. 22: 239-52. PMID 3361950 DOI: 10.1016/0165-0270(88)90045-3  1
1987 Michael AC, Justice JB. Oxidation of dopamine and 4-methylcatechol at carbon fiber disk electrodes. Analytical Chemistry. 59: 405-10. PMID 3565760 DOI: 10.1021/Ac00130A006  1
1987 Michael AC, Ikeda M, Justice JB. Mechanisms contributing to the recovery of striatal releasable dopamine following MFB stimulation. Brain Research. 421: 325-35. PMID 3500755 DOI: 10.1016/0006-8993(87)91302-3  1
1987 Michael AC, Ikeda M, Justice JB. Dynamics of the recovery of releasable dopamine following electrical stimulation of the medial forebrain bundle. Neuroscience Letters. 76: 81-6. PMID 3495755 DOI: 10.1016/0304-3940(87)90196-0  1
1985 Michael AC, Justice JB, Neill DB. In vivo voltammetric determination of the kinetics of dopamine metabolism in the rat. Neuroscience Letters. 56: 365-9. PMID 4022449 DOI: 10.1016/0304-3940(85)90270-8  1
1983 Justice JB, Blakely RD, Neill DB, Wages SA, Michael AC. Interpretations of Voltammetry in the Striatum Based on Chromatography of Striatal Dialysate Journal of Liquid Chromatography. 6: 1873-1896. DOI: 10.1080/01483918308064897  1
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